Lhcgr (luteinizing hormone/choriogonadotropin receptor) - Rat Genome Database

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Gene: Lhcgr (luteinizing hormone/choriogonadotropin receptor) Mus musculus
Analyze
Symbol: Lhcgr
Name: luteinizing hormone/choriogonadotropin receptor
RGD ID: 10870
MGI Page MGI
Description: Enables choriogonadotropin hormone binding activity and choriogonadotropin hormone receptor activity. Involved in G protein-coupled receptor signaling pathway; cellular response to gonadotropin stimulus; and positive regulation of inositol trisphosphate biosynthetic process. Acts upstream of or within several processes, including development of secondary male sexual characteristics; regulation of steroid hormone biosynthetic process; and reproductive structure development. Located in plasma membrane. Is expressed in early conceptus; medulla oblongata; medulla oblongata basal plate ventricular layer; oocyte; and testis. Human ortholog(s) of this gene implicated in Leydig cell hypoplasia; Leydig cell tumor; breast cancer; familial male-limited precocious puberty; and gonadal disease. Orthologous to human LHCGR (luteinizing hormone/choriogonadotropin receptor).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Gpcr19; Gpcr19-rs1; L; LH; LH-R; LH/CG-R; Lhr; LSH-R; luteinizing hormone receptor; lutropin-choriogonadotropic hormone receptor
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391789,023,812 - 89,099,487 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1789,023,909 - 89,099,418 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381788,716,384 - 88,792,059 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1788,716,481 - 88,791,990 (-)Ensemblmm10GRCm38
MGSCv371789,140,889 - 89,191,316 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361788,649,875 - 88,700,302 (-)NCBIMGSCv36mm8
Celera1793,149,952 - 93,199,996 (-)NCBICelera
Cytogenetic Map17E4NCBI
cM Map1758.35NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(E)-thiamethoxam  (EXP,ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
1,2-dichloroethane  (EXP)
1,3-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3',5'-cyclic AMP  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-tert-Octylphenol  (ISO)
8-Br-cAMP  (ISO)
acetamiprid  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP)
allethrin  (ISO)
alpha-naphthoflavone  (ISO)
amiodarone  (ISO)
ammonium chloride  (ISO)
antirheumatic drug  (ISO)
Aroclor 1254  (ISO)
arsenite(3-)  (EXP)
atrazine  (ISO)
Azoxymethane  (EXP)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bucladesine  (ISO)
butylated hydroxyanisole  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
captan  (EXP)
carvacrol  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (EXP)
Chorionic gonadotropin  (ISO)
chromium(6+)  (ISO)
colforsin daropate hydrochloride  (EXP)
cyanamide  (EXP)
cyhalothrin  (ISO)
cypermethrin  (ISO)
DDE  (ISO)
deoxynivalenol  (EXP)
dexamethasone  (ISO)
dextran sulfate  (EXP)
Di-n-hexyl phthalate  (ISO)
dibutyl phthalate  (EXP,ISO)
dibutylstannane  (ISO)
Dicyclohexyl phthalate  (ISO)
diethyl phthalate  (ISO)
diethylstilbestrol  (ISO)
diheptyl phthalate  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dipentyl phthalate  (ISO)
disulfiram  (EXP)
erythrosin B  (ISO)
fenvalerate  (ISO)
flurbiprofen  (ISO)
fulvestrant  (EXP)
gamma-hexachlorocyclohexane  (ISO)
genistein  (EXP,ISO)
hydroquinone O-beta-D-glucopyranoside  (ISO)
isoflavones  (ISO)
ketoconazole  (ISO)
L-ascorbic acid  (ISO)
L-mimosine  (EXP,ISO)
letrozole  (EXP)
leuprolide  (EXP)
linuron  (ISO)
LY294002  (ISO)
melatonin  (EXP)
melittin  (ISO)
methoxychlor  (ISO)
microcystin-LR  (EXP,ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
monobenzyl phthalate  (EXP)
Monobutylphthalate  (EXP)
monoethyl phthalate  (EXP)
N-ethyl-N-nitrosourea  (ISO)
p-tert-Amylphenol  (ISO)
paraquat  (ISO)
perfluorododecanoic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
perfluoroundecanoic acid  (ISO)
picrotoxin  (ISO)
potassium dichromate  (ISO)
prostaglandin F2alpha  (ISO)
pyrethrins  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
streptozocin  (ISO)
sulfur dioxide  (EXP)
T-2 toxin  (ISO)
tartrazine  (ISO)
testosterone  (EXP,ISO)
testosterone enanthate  (ISO)
Tetrachlorobisphenol A  (EXP,ISO)
thiamethoxam  (EXP,ISO)
titanium dioxide  (EXP)
tofacitinib  (ISO)
tributylstannane  (ISO)
triphenylstannane  (ISO)
tyrphostin AG 1478  (ISO)
uranium atom  (ISO)
vinclozolin  (ISO)
wortmannin  (EXP)
zearalenone  (EXP)
ziram  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of adenylate cyclase activity  (ISO)
adenylate cyclase-activating G protein-coupled receptor signaling pathway  (IBA,IDA)
adenylate cyclase-modulating G protein-coupled receptor signaling pathway  (IEA,ISO)
arachidonate secretion  (ISO)
cellular response to gonadotropin stimulus  (IDA)
cellular response to hormone stimulus  (IEA)
cellular response to luteinizing hormone stimulus  (IEA,ISO,ISS)
cognition  (IEA,ISO)
development of secondary male sexual characteristics  (IMP)
female gonad development  (IMP)
G protein-coupled receptor signaling pathway  (IEA)
hormone-mediated signaling pathway  (IBA,ISO)
luteinizing hormone signaling pathway  (IBA,IEA,ISO,ISS)
male gonad development  (IBA,IMP)
ovarian follicle development  (IBA,IMP)
ovulation cycle process  (IBA,IMP)
phospholipase C-activating G protein-coupled receptor signaling pathway  (IBA,IDA,IEA,ISO)
positive regulation of calcium ion transport into cytosol  (ISO)
positive regulation of calcium-mediated signaling  (ISO)
positive regulation of hormone biosynthetic process  (ISO)
positive regulation of inositol trisphosphate biosynthetic process  (IDA)
positive regulation of release of sequestered calcium ion into cytosol  (ISO)
protein targeting to lysosome  (ISO)
regulation of hormone biosynthetic process  (IEA)
regulation of steroid biosynthetic process  (IEA,ISO)
regulation of steroid hormone biosynthetic process  (IMP)
response to gonadotropin  (IEA)
response to luteinizing hormone  (ISO)
response to xenobiotic stimulus  (ISO)
seminiferous tubule development  (IMP)
signal transduction  (IEA)
spermatogenesis  (IMP)
uterus development  (IMP)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal abdominal fat pad morphology  (IAGP)
abnormal adult Leydig cell differentiation  (IAGP)
abnormal anogenital distance  (IAGP)
abnormal caput epididymis morphology  (IAGP)
abnormal cauda epididymis morphology  (IAGP)
abnormal ejaculation  (IAGP)
abnormal epididymis epithelium morphology  (IAGP)
abnormal epididymis morphology  (IAGP)
abnormal female reproductive system morphology  (IAGP)
abnormal male reproductive system morphology  (IAGP)
abnormal ovary morphology  (IAGP)
abnormal prostate gland morphology  (IAGP)
abnormal reproductive system physiology  (IAGP)
abnormal seminiferous tubule morphology  (IAGP)
abnormal sexual interaction  (IAGP)
abnormal sperm physiology  (IAGP)
abnormal testosterone level  (IAGP)
abnormal uterus morphology  (IAGP)
abnormal vagina development  (IAGP)
abnormal vagina orifice morphology  (IAGP)
absent corpus luteum  (IAGP)
absent endometrial glands  (IAGP)
absent estrous cycle  (IAGP)
absent estrus  (IAGP)
absent Leydig cells  (IAGP)
absent mature ovarian follicles  (IAGP)
ambiguous external female genitalia  (IAGP)
arrest of spermatogenesis  (IAGP)
bulbourethral gland hypoplasia  (IAGP)
cryptorchism  (IAGP)
decreased body weight  (IAGP)
decreased brain size  (IEA)
decreased circulating estradiol level  (IAGP)
decreased circulating follicle stimulating hormone level  (IAGP)
decreased circulating luteinizing hormone level  (IAGP)
decreased circulating progesterone level  (IAGP)
decreased circulating testosterone level  (IAGP)
decreased endometrial gland number  (IAGP)
decreased epididymal cell proliferation  (IAGP)
decreased epididymis weight  (IAGP)
decreased Leydig cell number  (IAGP)
decreased mean corpuscular volume  (IEA)
decreased ovary secretion  (IAGP)
decreased ovary weight  (IAGP)
decreased seminal vesicle weight  (IAGP)
decreased testes secretion  (IAGP)
decreased testis weight  (IAGP)
delayed vaginal opening  (IAGP)
early sexual maturation  (IAGP)
enlarged adrenal glands  (IAGP)
enlarged prostate gland  (IAGP)
enlarged seminal vesicle  (IAGP)
enlarged spleen  (IAGP)
epididymis hypoplasia  (IAGP)
epididymis inflammation  (IAGP)
external male genitalia atrophy  (IAGP)
female infertility  (IAGP)
impaired ovarian folliculogenesis  (IAGP)
increased adrenal gland weight  (IAGP)
increased body weight  (IAGP)
increased circulating estradiol level  (IAGP)
increased circulating follicle stimulating hormone level  (IAGP)
increased circulating luteinizing hormone level  (IAGP)
increased circulating testosterone level  (IAGP)
increased epididymis weight  (IAGP)
increased kidney weight  (IAGP)
increased leukocyte cell number  (IEA)
increased Leydig cell number  (IAGP)
increased lymphocyte cell number  (IEA)
increased male germ cell apoptosis  (IAGP)
increased prostate gland weight  (IAGP)
increased seminal vesicle weight  (IAGP)
increased urine major urinary protein level  (IAGP)
male infertility  (IAGP)
oligozoospermia  (IAGP)
prostate gland hypoplasia  (IAGP)
prostate gland inflammation  (IAGP)
reduced male fertility  (IAGP)
reproductive system inflammation  (IAGP)
scrotum hypoplasia  (IAGP)
seminal vesicle hypoplasia  (IAGP)
small epididymis  (IAGP)
small heart  (IEA)
small liver  (IEA)
small lung  (IEA)
small ovary  (IAGP)
small penis  (IAGP)
small prostate gland  (IAGP)
small prostate gland anterior lobe  (IAGP)
small seminal vesicle  (IAGP)
small seminiferous tubules  (IAGP)
small spleen  (IEA)
small stomach  (IEA)
small testis  (IAGP)
small thymus  (IEA)
testis hypoplasia  (IAGP)
thin endometrium  (IAGP)
thin myometrium  (IAGP)
thin uterine horn  (IAGP)
thin uterus  (IAGP)
thrombocytopenia  (IEA)
vas deferens hypoplasia  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. A novel targeted therapy of Leydig and granulosa cell tumors through the luteinizing hormone receptor using a hecate-chorionic gonadotropin beta conjugate in transgenic mice. Bodek G, etal., Neoplasia. 2005 May;7(5):497-508.
2. Mutational analysis of the luteinizing hormone receptor gene in two individuals with Leydig cell tumors. Canto P, etal., Am J Med Genet. 2002 Mar 1;108(2):148-52.
3. FSH-regulated gene expression profiles in ovarian tumours and normal ovaries. Chu S, etal., Mol Hum Reprod. 2002 May;8(5):426-33.
4. A new point mutation in the luteinising hormone receptor gene in familial and sporadic male limited precocious puberty: genotype does not always correlate with phenotype. Evans BA, etal., J Med Genet. 1996 Feb;33(2):143-7.
5. Lutropin-choriogonadotropin receptor: an unusual member of the G protein-coupled receptor family. McFarland KC, etal., Science. 1989 Aug 4;245(4917):494-9.
6. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
7. MGDs mouse GO annotations MGD data from the GO Consortium
8. MGD IEA MGD IEA
9. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. GnRH and LHR gene variants predict adverse outcome in premenopausal breast cancer patients. Piersma D, etal., Breast Cancer Res. 2007;9(4):R51.
12. Polymorphic variations in exon 10 of the luteinizing hormone receptor: functional consequences and associations with breast cancer. Piersma D, etal., Mol Cell Endocrinol. 2007 Sep 30;276(1-2):63-70. Epub 2007 Jul 17.
13. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
14. Luteinizing hormone signaling and breast cancer: polymorphisms and age of onset. Powell BL, etal., J Clin Endocrinol Metab. 2003 Apr;88(4):1653-7.
15. Mouse MP Annotation Import Pipeline RGD automated import pipeline
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Growth repression in diethylstilbestrol/dimethylbenzanthracene-induced rat mammary gland tumor using Hecate-CGbeta conjugate. Zaleska M, etal., Exp Biol Med (Maywood). 2004 Apr;229(4):335-44.
Additional References at PubMed
PMID:1311310   PMID:1459341   PMID:7556872   PMID:7672443   PMID:7720577   PMID:7736780   PMID:7892197   PMID:8252616   PMID:8288218   PMID:8559204   PMID:8575305   PMID:8751373  
PMID:8807640   PMID:8833235   PMID:8887325   PMID:9282997   PMID:9492048   PMID:9823302   PMID:10349636   PMID:10493819   PMID:10537163   PMID:11042159   PMID:11076861   PMID:11145748  
PMID:11145749   PMID:11217851   PMID:11226072   PMID:11312274   PMID:11943741   PMID:11988311   PMID:11988312   PMID:12032072   PMID:12604639   PMID:12865338   PMID:12933687   PMID:14585929  
PMID:14645113   PMID:14726449   PMID:15232063   PMID:15253923   PMID:15256532   PMID:15256533   PMID:15514086   PMID:15814897   PMID:15821112   PMID:15836959   PMID:15941853   PMID:15951841  
PMID:15970507   PMID:16024815   PMID:16034175   PMID:16141072   PMID:16141073   PMID:16293639   PMID:16361283   PMID:16412416   PMID:16602821   PMID:16730882   PMID:16919269   PMID:17065221  
PMID:17130239   PMID:17350160   PMID:17376589   PMID:17603480   PMID:17640960   PMID:17727840   PMID:19013498   PMID:20080658   PMID:20093417   PMID:20142765   PMID:20154177   PMID:20164437  
PMID:20798391   PMID:20805495   PMID:21267068   PMID:21389345   PMID:21873635   PMID:22875961   PMID:23136395   PMID:23261984   PMID:23464498   PMID:23471219   PMID:23861372   PMID:24067652  
PMID:24145128   PMID:24476692   PMID:25668066   PMID:25670721   PMID:25713029   PMID:25775596   PMID:25960166   PMID:26040673   PMID:26402718   PMID:26828746   PMID:27075695   PMID:27732090  
PMID:28339861   PMID:28455422   PMID:28531375   PMID:28911199   PMID:29584617   PMID:29890291   PMID:30541888   PMID:30793514   PMID:31250581   PMID:32011766   PMID:32301970   PMID:32325033  
PMID:32384146   PMID:32890905   PMID:33112284   PMID:33605422   PMID:34147365   PMID:34288113   PMID:35600595   PMID:36293309   PMID:37563278   PMID:37697644   PMID:37847612   PMID:38180498  
PMID:38355793   PMID:39031603   PMID:39262851  


Genomics

Comparative Map Data
Lhcgr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391789,023,812 - 89,099,487 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1789,023,909 - 89,099,418 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381788,716,384 - 88,792,059 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1788,716,481 - 88,791,990 (-)Ensemblmm10GRCm38
MGSCv371789,140,889 - 89,191,316 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361788,649,875 - 88,700,302 (-)NCBIMGSCv36mm8
Celera1793,149,952 - 93,199,996 (-)NCBICelera
Cytogenetic Map17E4NCBI
cM Map1758.35NCBI
LHCGR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38248,686,774 - 48,755,724 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl248,686,774 - 48,755,730 (-)Ensemblhg38GRCh38
GRCh37248,913,913 - 48,982,863 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36248,767,417 - 48,836,367 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34248,825,619 - 48,894,468NCBI
Celera248,754,221 - 48,823,183 (-)NCBICelera
Cytogenetic Map2p16.3NCBI
HuRef248,647,284 - 48,716,442 (-)NCBIHuRef
CHM1_1248,844,653 - 48,913,614 (-)NCBICHM1_1
T2T-CHM13v2.0248,682,806 - 48,751,772 (-)NCBIT2T-CHM13v2.0
Lhcgr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8611,415,361 - 11,480,834 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl611,415,415 - 11,478,061 (+)EnsemblGRCr8
mRatBN7.265,661,871 - 5,728,109 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl65,661,871 - 5,724,521 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx65,950,334 - 6,013,310 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.066,259,709 - 6,322,689 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.065,786,872 - 5,849,858 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0612,493,182 - 12,554,482 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl612,493,943 - 12,554,439 (-)Ensemblrn6Rnor6.0
Rnor_5.0622,455,216 - 22,516,430 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4612,613,622 - 12,651,587 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera65,442,191 - 5,504,330 (+)NCBICelera
RGSC_v3.1612,613,621 - 12,651,587 (-)NCBI
Cytogenetic Map6q12NCBI
Lhcgr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544115,207,252 - 15,242,914 (-)Ensembl
ChiLan1.0NW_00495544115,205,883 - 15,263,617 (-)NCBIChiLan1.0ChiLan1.0
LHCGR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21277,625,492 - 77,695,724 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A77,629,460 - 77,699,692 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A48,808,822 - 48,879,021 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A49,728,994 - 49,798,780 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A49,729,002 - 49,798,780 (-)EnsemblpanPan2panpan1.1
LHCGR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11050,540,706 - 50,594,336 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1050,541,960 - 50,598,036 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1050,394,259 - 50,456,607 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01051,416,899 - 51,479,209 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1051,417,733 - 51,474,628 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11051,119,798 - 51,182,164 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01051,404,008 - 51,466,313 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01051,595,139 - 51,657,483 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Lhcgr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629232,499,857 - 32,557,352 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365083,928,466 - 3,983,890 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365083,928,467 - 3,983,481 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LHCGR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl391,964,415 - 92,021,398 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1391,964,415 - 92,023,821 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2397,929,099 - 97,949,675 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap3q22-q23NCBI
LHCGR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11458,413,334 - 58,479,124 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1458,413,993 - 58,477,987 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604553,365,608 - 53,428,814 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lhcgr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473829,903,571 - 29,966,915 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473829,902,364 - 29,967,384 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Lhcgr
3061 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:122
Count of miRNA genes:95
Interacting mature miRNAs:108
Transcripts:ENSMUST00000024916
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301107Scc4_mcolon tumor susceptibility 4 (mouse)Not determined176230101095294699Mouse
4141758Pstc5_mperiosteal circumference 5 (mouse)Not determined175710765191107803Mouse
11039498Ltpr7b_mLeishmania tropica response 7b (mouse)177070119895294699Mouse
11039499Ltpr7a_mLeishmania tropica response 7a (mouse)177070119895294699Mouse
1357552Aaj4_manxiety in A/J 4 (mouse)Not determined177458908990395270Mouse
11039500Ltpr7c_mLeishmania tropica response 7c (mouse)177070119895294699Mouse
11528551Sluc32_msusceptibility to lung cancer 32 (mouse)176230101095294699Mouse
4141011Bmd26_mbone mineral density 26 (mouse)Not determined175710765191107803Mouse
1357528Nhdlq3_mnon-HDL QTL 3 (mouse)Not determined177339513295294699Mouse
1300735Pgia20_mproteoglycan induced arthritis 20 (mouse)Not determined175710765191107803Mouse
12910536Nrq8a_mnoise-induced hearing loss resistant QTL 8a (mouse)175710765191107803Mouse
14697708Stsl5_mSalmonella typhimurium susceptibility locus 5 (mouse)178080742991407428Mouse
12910537Nrq8_mnoise-induced hearing loss resistant QTL 8 (mouse)175710765191107803Mouse
4141040Hmtb9_mhemostasis and thrombosis rebleeding time 9 (mouse)Not determined5758908991589197Mouse
4142256Nilac12_mnicotine induced locomotor activity 12 (mouse)Not determined176894131995294699Mouse
4142414Pregq4_mpregnancy QTL 4 (mouse)Not determined175753444793507179Mouse
1302017Aliq3_macute lung injury QTL 3 (mouse)Not determined176388554895294699Mouse
11039514Ltpr7_mLeishmania tropica response 7 (mouse)177070119895294699Mouse
1301728Ffal1_mfree fatty acid level 1 (mouse)Not determined176521493895294699Mouse
1357447Heal13_mwound healing/regeneration 13 (mouse)Not determined175710765191107803Mouse
4141195Nilac11_mnicotine induced locomotor activity 11 (mouse)Not determined177339513295294699Mouse
14928308Manh82_mmandible shape 82 (mouse)176631524395294699Mouse
1357646Axtq3_manxiety QTL 3 (mouse)Not determined177458908990395270Mouse
4141697Hbnr3_mHeligmosomoides bakeri nematode resistance 3 (mouse)Not determined7410765193507179Mouse

Markers in Region
M81310  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381788,741,581 - 88,741,711UniSTSGRCm38
MGSCv371789,140,921 - 89,141,051UniSTSGRCm37
Celera1793,149,984 - 93,150,114UniSTS
Cytogenetic Map17E4-E5UniSTS
Lhcgr  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv371789,141,645 - 89,142,137UniSTSGRCm37
Celera1793,150,708 - 93,151,200UniSTS
Cytogenetic Map17E4-E5UniSTS
cM Map1746.5UniSTS
PMC85975P2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381788,742,085 - 88,742,629UniSTSGRCm38
MGSCv371789,141,425 - 89,141,969UniSTSGRCm37
Celera1793,150,488 - 93,151,032UniSTS
Cytogenetic Map17E4-E5UniSTS
Fshr  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map17E5UniSTS
Cytogenetic Map17E4-E5UniSTS
Fshr  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map17E5UniSTS
Cytogenetic Map17E4-E5UniSTS
cM Map17 UniSTS
LHCGR  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381788,742,305 - 88,742,797UniSTSGRCm38
MGSCv371789,141,645 - 89,142,137UniSTSGRCm37
Celera1793,150,708 - 93,151,200UniSTS
Cytogenetic Map17E4-E5UniSTS
Lhcgr  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map17E4-E5UniSTS
Lhcgr  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map17E4-E5UniSTS
cM Map1746.5UniSTS
Lhcgr  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map17E5UniSTS
Cytogenetic Map17E4-E5UniSTS
Lhcgr  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map17E5UniSTS
Cytogenetic Map17E4-E5UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001364898 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_013582 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_157357 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006523719 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006523720 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006523721 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006523722 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006523723 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011246310 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036160339 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036160340 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036160341 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036160342 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036160343 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036160344 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC154459 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK030325 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK054331 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK054542 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK138461 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466537 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M81310 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M87571 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S49753 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000024916   ⟹   ENSMUSP00000024916
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1789,044,702 - 89,099,404 (-)Ensembl
GRCm38.p6 Ensembl1788,737,274 - 88,791,976 (-)Ensembl
Ensembl Acc Id: ENSMUST00000234269
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1789,072,305 - 89,099,399 (-)Ensembl
GRCm38.p6 Ensembl1788,764,877 - 88,791,971 (-)Ensembl
Ensembl Acc Id: ENSMUST00000234368   ⟹   ENSMUSP00000157318
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1789,047,134 - 89,099,418 (-)Ensembl
GRCm38.p6 Ensembl1788,739,706 - 88,791,990 (-)Ensembl
Ensembl Acc Id: ENSMUST00000234881
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1789,023,909 - 89,081,484 (-)Ensembl
GRCm38.p6 Ensembl1788,716,481 - 88,774,056 (-)Ensembl
RefSeq Acc Id: NM_001364898   ⟹   NP_001351827
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391789,044,702 - 89,099,442 (-)NCBI
GRCm381788,737,274 - 88,792,014 (-)NCBI
Sequence:
RefSeq Acc Id: NM_013582   ⟹   NP_038610
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391789,044,702 - 89,099,442 (-)NCBI
GRCm381788,737,274 - 88,792,014 (-)NCBI
MGSCv371789,140,889 - 89,191,316 (-)RGD
Celera1793,149,952 - 93,199,996 (-)RGD
cM Map17 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_157357
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391789,044,702 - 89,099,442 (-)NCBI
GRCm381788,737,274 - 88,792,014 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006523719   ⟹   XP_006523782
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391789,047,052 - 89,099,487 (-)NCBI
GRCm381788,739,624 - 88,792,059 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006523720   ⟹   XP_006523783
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391789,047,052 - 89,099,487 (-)NCBI
GRCm381788,739,624 - 88,792,059 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006523721   ⟹   XP_006523784
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391789,047,052 - 89,099,487 (-)NCBI
GRCm381788,739,624 - 88,792,059 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006523722   ⟹   XP_006523785
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391789,047,052 - 89,099,487 (-)NCBI
GRCm381788,739,624 - 88,792,059 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006523723   ⟹   XP_006523786
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391789,047,052 - 89,099,487 (-)NCBI
GRCm381788,739,624 - 88,792,059 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011246310   ⟹   XP_011244612
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391789,023,812 - 89,099,487 (-)NCBI
GRCm381788,716,384 - 88,792,059 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036160339   ⟹   XP_036016232
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391789,047,052 - 89,099,487 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036160340   ⟹   XP_036016233
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391789,047,052 - 89,099,487 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036160341   ⟹   XP_036016234
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391789,050,320 - 89,099,487 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036160342   ⟹   XP_036016235
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391789,050,485 - 89,099,487 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036160343   ⟹   XP_036016236
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391789,024,406 - 89,099,487 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036160344   ⟹   XP_036016237
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391789,050,598 - 89,099,487 (-)NCBI
Sequence:
RefSeq Acc Id: NP_038610   ⟸   NM_013582
- Peptide Label: isoform 1 precursor
- UniProtKB: P30730 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006523786   ⟸   XM_006523723
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_006523785   ⟸   XM_006523722
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_006523783   ⟸   XM_006523720
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_006523782   ⟸   XM_006523719
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006523784   ⟸   XM_006523721
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_011244612   ⟸   XM_011246310
- Peptide Label: isoform X9
- Sequence:
RefSeq Acc Id: NP_001351827   ⟸   NM_001364898
- Peptide Label: isoform 2 precursor
Ensembl Acc Id: ENSMUSP00000024916   ⟸   ENSMUST00000024916
Ensembl Acc Id: ENSMUSP00000157318   ⟸   ENSMUST00000234368
RefSeq Acc Id: XP_036016236   ⟸   XM_036160343
- Peptide Label: isoform X11
RefSeq Acc Id: XP_036016232   ⟸   XM_036160339
- Peptide Label: isoform X2
RefSeq Acc Id: XP_036016233   ⟸   XM_036160340
- Peptide Label: isoform X7
RefSeq Acc Id: XP_036016234   ⟸   XM_036160341
- Peptide Label: isoform X8
RefSeq Acc Id: XP_036016235   ⟸   XM_036160342
- Peptide Label: isoform X10
RefSeq Acc Id: XP_036016237   ⟸   XM_036160344
- Peptide Label: isoform X12

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P30730-F1-model_v2 AlphaFold P30730 1-700 view protein structure

Promoters
RGD ID:13676978
Promoter ID:EPDNEW_M22638
Type:multiple initiation site
Name:Lhcgr_1
Description:Mus musculus luteinizing hormone/choriogonadotropin receptor, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381788,791,990 - 88,792,050EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:96783 AgrOrtholog
Ensembl Genes ENSMUSG00000024107 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000024916 ENTREZGENE
  ENSMUST00000024916.7 UniProtKB/Swiss-Prot
Gene3D-CATH 3.80.10.10 UniProtKB/Swiss-Prot
  Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
  Gphrmn_rcpt_fam UniProtKB/Swiss-Prot
  LRR_5 UniProtKB/Swiss-Prot
  LRR_dom_sf UniProtKB/Swiss-Prot
  LSH_rcpt UniProtKB/Swiss-Prot
KEGG Report mmu:16867 UniProtKB/Swiss-Prot
MGD MGI:96783 ENTREZGENE
NCBI Gene 16867 ENTREZGENE
PANTHER GLYCOPROTEIN HORMONE RECEPTOR UniProtKB/Swiss-Prot
  LUTROPIN-CHORIOGONADOTROPIC HORMONE RECEPTOR UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
  LRR_5 UniProtKB/Swiss-Prot
PhenoGen Lhcgr PhenoGen
PRINTS GLYCHORMONER UniProtKB/Swiss-Prot
  GPCRRHODOPSN UniProtKB/Swiss-Prot
  LSHRECEPTOR UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot
  L domain-like UniProtKB/Swiss-Prot
UniProt A0A3Q4EH58_MOUSE UniProtKB/TrEMBL
  LSHR_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE