Lepr (leptin receptor) - Rat Genome Database

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Gene: Lepr (leptin receptor) Mus musculus
Symbol: Lepr
Name: leptin receptor
RGD ID: 10865
Description: Enables leptin receptor activity. Involved in several processes, including glucose homeostasis; leptin-mediated signaling pathway; and positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including glial cell proliferation; glycogen metabolic process; and negative regulation of gluconeogenesis. Predicted to be located in extracellular space. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and skeleton. Used to study non-alcoholic fatty liver disease; obesity; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); non-alcoholic fatty liver disease (multiple); obesity; obstructive sleep apnea; and type 2 diabetes mellitus. Orthologous to human LEPR (leptin receptor).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: B219; db; diabetes; LE; LEP-R; Leprb; LEPROT; leptin receptor gene-related protein; MGC105189; Modb; Modb1; O; OB receptor; OB-; OB-RGRP; obese-; obese-like; obl; Obr
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm394101,574,393 - 101,676,375 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4101,574,601 - 101,672,549 (+)EnsemblGRCm39 Ensembl
GRCm384101,717,137 - 101,815,352 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4101,717,404 - 101,815,352 (+)EnsemblGRCm38mm10GRCm38
MGSCv374101,390,012 - 101,487,959 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364101,215,371 - 101,313,237 (+)NCBIMGSCv36mm8
Celera4100,061,452 - 100,155,523 (+)NCBICelera
Cytogenetic Map4C6NCBI
cM Map446.96NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
Albuminuria  (ISO)
Animal Disease Models  (ISO)
arteriosclerosis  (ISO)
bone disease  (ISO)
Breast Neoplasms  (ISO)
cardiomyopathy  (ISO)
Chronic Hepatitis B  (ISO)
Chronic Hepatitis C  (ISO)
chronic kidney disease  (ISO)
chronic obstructive pulmonary disease  (ISO)
cognitive disorder  (ISO)
congestive heart failure  (IEP)
coronary artery disease  (ISO)
Coronary Disease  (ISO)
Delayed Puberty  (ISO)
diabetes mellitus  (ISO)
Diabetic Cardiomyopathies  (ISO)
Diabetic Nephropathies  (ISO)
diabetic neuropathy  (ISO)
dilated cardiomyopathy  (ISO)
Dyslipidemias  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
familial hyperlipidemia  (ISO)
fatty liver disease  (ISO)
Female Infertility  (ISO)
Fibrosis  (ISO)
genetic disease  (ISO)
gestational diabetes  (ISO)
Gliosis  (ISO)
glucose intolerance  (ISO)
granulosa cell tumor  (ISO)
hepatocellular carcinoma  (ISO)
hepatocellular clear cell carcinoma  (ISO)
Hepatomegaly  (ISO)
human immunodeficiency virus infectious disease  (ISO)
Hyperalgesia  (ISO)
hyperglycemia  (ISO)
hyperinsulinism  (ISO)
Hyperphagia  (ISO)
hypertension  (ISO)
hypogonadism  (ISO)
infertility  (IMP,ISO)
inherited metabolic disorder  (ISO)
Insulin Resistance  (ISO)
intellectual disability  (ISO)
kidney disease  (ISO)
kidney failure  (ISO)
Knee Osteoarthritis  (ISO)
Left Ventricular Hypertrophy  (ISO)
Leptin Receptor Deficiency  (ISO)
morbid obesity  (ISO)
Myocardial Ischemia  (ISO)
Myocardial Reperfusion Injury  (ISO)
Nasal Polyps  (ISO)
nephritis  (ISO)
non-alcoholic fatty liver disease  (IAGP,ISO)
non-alcoholic steatohepatitis  (ISO)
obesity  (IAGP,IEP,IMP,ISO)
obstructive sleep apnea  (ISO)
osteoporosis  (ISO)
Overweight  (ISO)
pancreas disease  (ISO)
pancreatitis  (ISO)
pituitary gland disease  (ISO)
Pneumococcal Pneumonia  (IMP)
pre-eclampsia  (ISO)
Precocious Puberty  (ISO)
primary biliary cholangitis  (ISO)
primary immunodeficiency disease  (ISO)
primary ovarian insufficiency  (ISO)
proteinuria  (ISO)
pulmonary fibrosis  (IMP)
pulmonary hypertension  (ISO)
renal fibrosis  (ISO)
Respiratory Tract Infections  (ISO)
Right Ventricular Hypertrophy  (ISO)
short bowel syndrome  (ISO)
sleep apnea  (ISO)
Spinal Fractures  (ISO)
type 2 diabetes mellitus  (IAGP,IMP,ISO)
Varicose Ulcer  (ISO)
Ventricular Dysfunction, Left  (ISO)
Weight Gain  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (EXP)
(N(omega)-L-arginino)succinic acid  (EXP)
(R)-carnitine  (EXP)
(R)-pantothenic acid  (EXP)
(S)-nicotine  (ISO)
1,2-dichloroethane  (EXP)
1-methylnicotinamide  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
2-amino-2-deoxy-D-galactopyranose  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-hydroxy-4-methylvaleric acid  (EXP)
2-hydroxyisobutyric acid  (EXP)
2-hydroxypropanoic acid  (EXP)
2-methyl-4-chlorophenoxybutyric acid  (ISO)
2-oxoadipic acid  (EXP)
3-methyl-2-oxobutanoic acid  (EXP)
3-methyl-2-oxovaleric acid  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxy-TEMPO  (EXP)
4-phenylbutyric acid  (EXP)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (EXP)
8-Br-cAMP  (ISO)
acetamide  (ISO)
acetohydrazide  (EXP)
acetylcholine  (EXP)
acrolein  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (EXP,ISO)
allantoin  (EXP)
allethrin  (ISO)
allopurinol  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
apocynin  (EXP)
aristolochic acid A  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
astaxanthin  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP)
beta-D-glucosamine  (ISO)
beta-naphthoflavone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bromodichloromethane  (EXP)
butanal  (ISO)
butyric acid  (EXP)
caffeine  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
captopril  (EXP)
carbon nanotube  (EXP)
CGP 52608  (ISO)
chloroquine  (EXP)
chlorpyrifos  (EXP)
cholesterol  (EXP)
choline  (EXP)
chromium atom  (EXP)
chrysene  (EXP)
ciguatoxin CTX1B  (EXP)
cisplatin  (ISO)
citric acid  (EXP)
clofibrate  (ISO)
clofibric acid  (ISO)
coumestrol  (ISO)
creatinine  (EXP)
crocidolite asbestos  (EXP)
cyanocob(III)alamin  (EXP)
cycloheximide  (EXP)
cyclosporin A  (ISO)
cyhalothrin  (ISO)
cypermethrin  (ISO)
cyromazine  (ISO)
cytarabine  (ISO)
D-glucose  (EXP,ISO)
dactolisib  (EXP)
decabromodiphenyl ether  (ISO)
dexamethasone  (ISO)
dibenz[a,h]anthracene  (EXP)
dibutyl phthalate  (ISO)
dichloroacetic acid  (EXP)
diclofenac  (EXP)
dicrotophos  (ISO)
diethyl maleate  (ISO)
dioxygen  (EXP,ISO)
diquat  (EXP)
dobutamine  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
Enterolactone  (ISO)
epoxiconazole  (EXP)
estrone  (EXP)
ethanol  (EXP,ISO)
ethylmalonic acid  (EXP)
fenvalerate  (ISO)
flutamide  (ISO)
folic acid  (EXP)
formic acid  (EXP)
fructose  (ISO)
fumaric acid  (EXP)
furan  (ISO)
galactaric acid  (EXP)
gefitinib  (ISO)
genistein  (ISO)
glucagon  (EXP)
glucose  (EXP,ISO)
glutaric acid  (EXP)
glutathione  (ISO)
glycidol  (ISO)
glycine betaine  (EXP)
glyphosate  (ISO)
gypenoside LXXV  (EXP)
harmine  (EXP)
hesperidin  (EXP)
hexanoic acid  (EXP)
high-density lipoprotein cholesterol  (ISO)
hydrazine  (ISO)
hydrochlorothiazide  (EXP)
hydrogen peroxide  (EXP)
indoxyl sulfate  (EXP)
isobutyric acid  (EXP)
isocaproic acid  (EXP)
isoprenaline  (ISO)
isovaleric acid  (EXP)
ketamine  (ISO)
L-methionine  (EXP)
lipopolysaccharide  (ISO)
LY294002  (EXP)
malonic acid  (EXP)
mercury atom  (ISO)
mercury(0)  (ISO)
methylmalonic acid  (EXP)
methylmercury chloride  (EXP,ISO)
metyrapone  (ISO)
mifepristone  (ISO)
MK-2206  (EXP)
morphine  (EXP)
N-[3-(aminomethyl)benzyl]acetamidine  (ISO)
N-ethyl-N-nitrosourea  (EXP)
N-methyl-6-pyridone-3-carboxamide  (EXP)
N-methylnicotinate  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
naringin  (EXP,ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
Nicotinamide N-oxide  (EXP)
nicotine  (ISO)
nicotinic acid  (EXP)
orotic acid  (EXP)
ozone  (EXP,ISO)
paracetamol  (EXP)
PCB138  (EXP)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP,ISO)
phenformin  (ISO)
phenobarbital  (EXP,ISO)
phenylmercury acetate  (ISO)
pioglitazone  (EXP,ISO)
pirimicarb  (ISO)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
propranolol  (ISO)
pyrethrins  (ISO)
quercetin  (ISO)
rac-lactic acid  (EXP)
raloxifene  (ISO)
razoxane  (ISO)
resveratrol  (EXP)
riddelliine  (ISO)
rotenone  (ISO)
rutin  (ISO)
SB 203580  (EXP)
SB 431542  (EXP,ISO)
silicon dioxide  (ISO)
simvastatin  (ISO)
sodium arsenite  (EXP)
sodium dichromate  (ISO)
streptozocin  (EXP)
succinic acid  (EXP)
sucrose  (EXP)
sulforaphane  (EXP)
superoxide  (EXP)
tacrine  (ISO)
taurine  (EXP)
telmisartan  (EXP)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (EXP)
thioacetamide  (ISO)
thiram  (ISO)
titanium dioxide  (EXP)
topotecan  (ISO)
tremolite asbestos  (EXP)
tributylstannane  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (EXP)
triphenyl phosphate  (EXP)
Triptolide  (EXP)
triptonide  (EXP)
troglitazone  (ISO)
urea  (EXP)
valeric acid  (EXP)
valproic acid  (EXP,ISO)
zinc atom  (EXP,ISO)
zinc(0)  (EXP,ISO)
ziram  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal acute inflammation  (IAGP)
abnormal adipose tissue morphology  (IAGP)
abnormal adipose tissue physiology  (IAGP)
abnormal adrenal gland zona reticularis morphology  (IEA)
abnormal aerobic respiration  (IAGP)
abnormal aorta morphology  (IAGP)
abnormal axon extension  (IAGP)
abnormal axon morphology  (IAGP)
abnormal behavior  (IAGP)
abnormal blood circulation  (IAGP)
abnormal blood homeostasis  (IAGP)
abnormal body composition  (IAGP)
abnormal body temperature  (IAGP)
abnormal body temperature homeostasis  (IAGP)
abnormal body weight  (IAGP)
abnormal bone structure  (IEA)
abnormal cardiovascular system physiology  (IAGP)
abnormal CD4-positive, alpha beta T cell morphology  (IAGP)
abnormal CD8-positive, alpha beta T cell morphology  (IAGP)
abnormal chemokine level  (IAGP)
abnormal chemokine secretion  (IAGP)
abnormal circadian temperature homeostasis  (IAGP)
abnormal circulating cholesterol level  (IAGP)
abnormal circulating glucose level  (IAGP)
abnormal circulating insulin level  (IAGP)
abnormal circulating lipid level  (IAGP)
abnormal CNS synaptic transmission  (IAGP)
abnormal conditioned taste aversion behavior  (IAGP)
abnormal diestrus  (IAGP)
abnormal digestive system physiology  (IAGP)
abnormal eating behavior  (IAGP)
abnormal embryo implantation  (IAGP)
abnormal endometrium morphology  (IAGP)
abnormal energy expenditure  (IAGP)
abnormal enzyme/coenzyme activity  (IAGP)
abnormal epididymal fat pad morphology  (IAGP)
abnormal estrous cycle  (IEA)
abnormal exocrine pancreas morphology  (IAGP)
abnormal eye electrophysiology  (IAGP)
abnormal fat pad morphology  (IAGP)
abnormal female reproductive system morphology  (IAGP)
abnormal food intake  (IAGP)
abnormal functional residual capacity  (IAGP)
abnormal gait  (IEA)
abnormal gluconeogenesis  (IAGP)
abnormal glucose homeostasis  (IAGP)
abnormal gonadal fat pad morphology  (IAGP)
abnormal hematopoietic system morphology/development  (IAGP)
abnormal hormone level  (IAGP)
abnormal hypothalamus physiology  (IAGP)
abnormal inhibitory postsynaptic currents  (IAGP)
abnormal insulin secretion  (IAGP)
abnormal interleukin level  (IAGP)
abnormal intestinal epithelium morphology  (IAGP)
abnormal intraocular pressure  (IAGP)
abnormal kidney afferent arteriole morphology  (IAGP)
abnormal kidney calyx morphology  (IAGP)
abnormal kidney morphology  (IAGP)
abnormal kidney papilla morphology  (IAGP)
abnormal lactation  (IAGP)
abnormal learning/memory/conditioning  (IAGP)
abnormal leukocyte morphology  (IAGP)
abnormal lipid level  (IAGP)
abnormal locomotor activation  (IAGP)
abnormal locomotor behavior  (IEA)
abnormal locomotor circadian rhythm  (IAGP)
abnormal lung compliance  (IAGP)
abnormal mesenteric fat pad morphology  (IAGP)
abnormal metestrus  (IAGP)
abnormal mitochondrial physiology  (IAGP)
abnormal myelin sheath morphology  (IAGP)
abnormal myocardial fiber morphology  (IAGP)
abnormal myocardium layer morphology  (IAGP)
abnormal nephron morphology  (IAGP)
abnormal nerve conduction  (IAGP)
abnormal nervous system electrophysiology  (IAGP)
abnormal nervous system morphology  (IAGP)
abnormal neuron physiology  (IAGP)
abnormal nucleotide metabolism  (IAGP)
abnormal osteoclast differentiation  (IAGP)
abnormal oxygen consumption  (IAGP)
abnormal pancreas physiology  (IAGP)
abnormal pancreatic beta cell morphology  (IAGP)
abnormal pancreatic beta cell physiology  (IAGP)
abnormal pancreatic islet cell apoptosis  (IAGP)
abnormal pancreatic islet morphology  (IAGP)
abnormal parturition  (IAGP)
abnormal pelvic girdle bone morphology  (IEA)
abnormal percent body fat/body weight  (IAGP)
abnormal podocyte morphology  (IAGP)
abnormal renal fat pad morphology  (IAGP)
abnormal renal glomerulus morphology  (IAGP)
abnormal respiratory electron transport chain  (IAGP)
abnormal respiratory mechanics  (IAGP)
abnormal response to cardiac infarction  (IAGP)
abnormal response/metabolism to endogenous compounds  (IAGP)
abnormal retina morphology  (IAGP)
abnormal retina vasculature morphology  (IAGP)
abnormal skeleton development  (IAGP)
abnormal spatial learning  (IAGP)
abnormal spatial reference memory  (IAGP)
abnormal sympathetic nervous system physiology  (IAGP)
abnormal synaptic dopamine release  (IAGP)
abnormal urine protein level  (IAGP)
abnormal uterus morphology  (IAGP)
abnormal vascular development  (IAGP)
abnormal vascular wound healing  (IAGP)
abnormal white adipose tissue morphology  (IAGP)
absent adrenal medulla  (IEA)
absent corpus luteum  (IAGP)
absent estrous cycle  (IAGP)
absent estrus  (IAGP)
absent long-term depression  (IAGP)
absent mature ovarian follicles  (IAGP)
adipose tissue inflammation  (IAGP)
albuminuria  (IAGP)
amyloidosis  (IAGP)
anovulation  (IAGP)
cardiac ischemia  (IAGP)
constricted vagina orifice  (IAGP)
decreased abdominal adipose tissue amount  (IAGP)
decreased body fat mass  (IAGP)
decreased body length  (IAGP)
decreased body size  (IAGP)
decreased body temperature  (IAGP)
decreased body weight  (IAGP)
decreased bone marrow cell number  (IAGP)
decreased bone mineral content  (IEA)
decreased bone mineral density  (IEA)
decreased carbon dioxide production  (IAGP)
decreased cardiac muscle contractility  (IAGP)
decreased cardiac output  (IAGP)
decreased CD4-positive, alpha-beta T cell number  (IAGP)
decreased CD8-positive, naive alpha-beta T cell number  (IEA)
decreased cell death  (IEA)
decreased circulating adiponectin level  (IAGP)
decreased circulating adrenaline level  (IAGP)
decreased circulating chloride level  (IEA)
decreased circulating cholesterol level  (IAGP)
decreased circulating glucose level  (IAGP)
decreased circulating growth hormone level  (IAGP)
decreased circulating insulin level  (IAGP)
decreased circulating leptin level  (IAGP)
decreased circulating noradrenaline level  (IAGP)
decreased circulating thyroxine level  (IAGP)
decreased circulating triglyceride level  (IAGP)
decreased core body temperature  (IAGP)
decreased corpora lutea number  (IEA)
decreased energy expenditure  (IAGP)
decreased exploration in new environment  (IEA)
decreased follicle stimulating hormone level  (IAGP)
decreased gonadal fat pad weight  (IAGP)
decreased heart rate  (IAGP)
decreased heart weight  (IEA)
decreased hematopoietic cell number  (IAGP)
decreased insulin secretion  (IAGP)
decreased lean body mass  (IAGP)
decreased leukocyte cell number  (IAGP)
decreased litter size  (IAGP)
decreased liver triglyceride level  (IAGP)
decreased locomotor activity  (IAGP)
decreased lymphocyte cell number  (IEA)
decreased mature ovarian follicle number  (IEA)
decreased motor neuron number  (IAGP)
decreased muscle weight  (IAGP)
decreased oocyte number  (IEA)
decreased ovulation rate  (IAGP)
decreased oxygen consumption  (IAGP)
decreased prostaglandin level  (IAGP)
decreased pulmonary ventilation  (IAGP)
decreased renal glomerular filtration rate  (IAGP)
decreased respiratory quotient  (IAGP)
decreased response to antigen  (IEA)
decreased somatotroph cell number  (IAGP)
decreased spleen weight  (IEA)
decreased splenocyte number  (IAGP)
decreased susceptibility to age related obesity  (IAGP)
decreased systemic arterial blood pressure  (IAGP)
decreased systemic arterial systolic blood pressure  (IAGP)
decreased T cell proliferation  (IAGP)
decreased total body fat amount  (IAGP)
decreased urine albumin level  (IAGP)
decreased uterus weight  (IAGP)
decreased white fat cell size  (IAGP)
degranulated pancreatic beta cells  (IAGP)
delayed estrous cycle  (IAGP)
delayed estrus  (IAGP)
delayed parturition  (IAGP)
delayed wound healing  (IAGP)
dystocia  (IAGP)
enlarged adrenal glands  (IEA)
enlarged kidney  (IAGP)
enlarged liver  (IAGP)
enlarged placenta  (IAGP)
enlarged spleen  (IAGP)
expanded mesangial matrix  (IAGP)
extended life span  (IAGP)
extramedullary hematopoiesis  (IAGP)
female infertility  (IAGP)
glomerulosclerosis  (IAGP)
heart left ventricle hypertrophy  (IAGP)
hepatic steatosis  (IAGP)
hyperactivity  (IAGP)
hyperglycemia  (IAGP)
hyperlipidemia  (IAGP)
hypoglycemia  (IAGP)
impaired adaptive thermogenesis  (IAGP)
impaired balance  (IEA)
impaired coordination  (IEA)
impaired glucose tolerance  (IAGP)
impaired righting response  (IEA)
improved glucose tolerance  (IAGP)
increased abdominal adipose tissue amount  (IAGP)
increased anxiety-related response  (IEA)
increased birth weight  (IAGP)
increased blood urea nitrogen level  (IAGP)
increased blood uric acid level  (IAGP)
increased body fat mass  (IEA)
increased body length  (IAGP)
increased body size  (IAGP)
increased body weight  (IAGP)
increased bone volume  (IAGP)
increased brown adipose tissue amount  (IAGP)
increased carbon dioxide production  (IAGP)
increased cholesterol level  (IAGP)
increased circulating alanine transaminase level  (IEA)
increased circulating alkaline phosphatase level  (IEA)
increased circulating amylase level  (IEA)
increased circulating aspartate transaminase level  (IEA)
increased circulating calcium level  (IEA)
increased circulating cholesterol level  (IAGP)
increased circulating corticosterone level  (IAGP)
increased circulating creatinine level  (IAGP)
increased circulating free fatty acids level  (IAGP)
increased circulating fructosamine level  (IEA)
increased circulating glucagon level  (IAGP)
increased circulating glucose level  (IAGP)
increased circulating glycerol level  (IAGP)
increased circulating HDL cholesterol level  (IAGP)
increased circulating insulin level  (IAGP)
increased circulating interleukin-6 level  (IAGP)
increased circulating iron level  (IEA)
increased circulating ketone body level  (IAGP)
increased circulating LDL cholesterol level  (IAGP)
increased circulating leptin level  (IAGP)
increased circulating phosphate level  (IEA)
increased circulating potassium level  (IEA)
increased circulating serum albumin level  (IEA)
increased circulating testosterone level  (IAGP)
increased circulating total protein level  (IEA)
increased circulating triglyceride level  (IAGP)
increased circulating VLDL cholesterol level  (IAGP)
increased creatinine clearance  (IAGP)
increased effector memory CD4-positive, alpha-beta T cell number  (IEA)
increased effector memory CD8-positive, alpha-beta T cell number  (IEA)
increased enterocyte apoptosis  (IAGP)
increased eosinophil cell number  (IEA)
increased epididymal fat pad weight  (IAGP)
increased fat cell size  (IAGP)
increased fluid intake  (IAGP)
increased food intake  (IAGP)
increased glucagon secretion  (IAGP)
increased glycosylated hemoglobin level  (IAGP)
increased gonadal fat pad weight  (IAGP)
increased heart weight  (IAGP)
increased hematocrit  (IEA)
increased hemoglobin content  (IEA)
increased hepatocyte apoptosis  (IAGP)
increased IgE level  (IEA)
increased insulin secretion  (IAGP)
increased insulin sensitivity  (IAGP)
increased interleukin-6 secretion  (IAGP)
increased kidney weight  (IAGP)
increased lean body mass  (IAGP)
increased left ventricle diastolic pressure  (IAGP)
increased liver glycogen level  (IEA)
increased liver triglyceride level  (IAGP)
increased liver weight  (IAGP)
increased mean corpuscular hemoglobin  (IEA)
increased mean corpuscular volume  (IEA)
increased mean platelet volume  (IEA)
increased mean systemic arterial blood pressure  (IAGP)
increased mesenteric fat pad weight  (IAGP)
increased metastatic potential  (IAGP)
increased monocyte cell number  (IEA)
increased neutrophil cell number  (IAGP)
increased omental fat pad weight  (IAGP)
increased oxygen consumption  (IAGP)
increased pancreatic alpha cell number  (IAGP)
increased pancreatic beta cell mass  (IAGP)
increased pancreatic beta cell number  (IAGP)
increased pancreatic islet cell apoptosis  (IAGP)
increased percent body fat/body weight  (IAGP)
increased red blood cell distribution width  (IEA)
increased renal glomerulus apoptosis  (IAGP)
increased renal glomerulus basement membrane thickness  (IAGP)
increased respiratory quotient  (IAGP)
increased subcutaneous adipose tissue amount  (IAGP)
increased susceptibility to age related obesity  (IAGP)
increased susceptibility to autoimmune diabetes  (IAGP)
increased susceptibility to diet-induced obesity  (IAGP)
increased susceptibility to endotoxin shock  (IAGP)
increased susceptibility to induced morbidity/mortality  (IAGP)
increased susceptibility to non-insulin-dependent diabetes  (IAGP)
increased susceptibility to parasitic infection  (IAGP)
increased susceptibility to weight gain  (IAGP)
increased systemic arterial systolic blood pressure  (IAGP)
increased total body fat amount  (IAGP)
increased urine glucose level  (IAGP)
increased urine protein level  (IAGP)
increased vasoconstriction  (IAGP)
infertility  (IAGP)
insulin resistance  (IAGP)
lethality, incomplete penetrance  (IAGP)
limb grasping  (IEA)
liver fibrosis  (IAGP)
liver inflammation  (IAGP)
lung inflammation  (IAGP)
macrovesicular hepatic steatosis  (IAGP)
male infertility  (IAGP)
maternal effect  (IAGP)
mesangiolysis  (IAGP)
microvesicular hepatic steatosis  (IAGP)
no abnormal phenotype detected  (IAGP)
obese  (IAGP)
ovary inflammation  (IAGP)
oxidative stress  (IAGP)
pancreas inflammation  (IAGP)
pancreatic islet hyperplasia  (IAGP)
periinsulitis  (IAGP)
polydipsia  (IAGP)
polyphagia  (IAGP)
polyuria  (IAGP)
premature death  (IAGP)
pup cannibalization  (IAGP)
reduced female fertility  (IAGP)
reduced long-term potentiation  (IAGP)
reduced male fertility  (IEA)
reduced male mating frequency  (IAGP)
renal glomerular immunoglobulin deposits  (IAGP)
renal glomerular protein deposits  (IAGP)
renal glomerulus fibrosis  (IAGP)
renal glomerulus lipidosis  (IAGP)
short femur  (IAGP)
short tail  (IAGP)
short tibia  (IEA)
small male preputial gland  (IAGP)
small seminal vesicle  (IEA)
small uterus  (IAGP)
spleen hyperplasia  (IAGP)
thrombocytopenia  (IEA)
tremors  (IEA)
trunk curl  (IEA)
weight loss  (IAGP)

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