Kdr (kinase insert domain protein receptor) - Rat Genome Database

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Gene: Kdr (kinase insert domain protein receptor) Mus musculus
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Symbol: Kdr
Name: kinase insert domain protein receptor
RGD ID: 10836
MGI Page MGI
Description: Enables coreceptor activity; growth factor binding activity; and vascular endothelial growth factor receptor activity. Involved in several processes, including circulatory system development; peptidyl-tyrosine autophosphorylation; and positive regulation of BMP signaling pathway. Acts upstream of or within several processes, including positive regulation of cell population proliferation; post-embryonic camera-type eye morphogenesis; and vasculature development. Located in several cellular components, including cell junction; endosome; and external side of plasma membrane. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; extraembryonic component; and genitourinary system. Human ortholog(s) of this gene implicated in several diseases, including adhesions of uterus; artery disease (multiple); gastrointestinal system cancer (multiple); macular degeneration (multiple); and pancreatic cancer (multiple). Orthologous to human KDR (kinase insert domain receptor).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 6130401C07; fetal liver kinase 1; Flk; Flk-; Flk-1; Flk1; kinase NYK; Krd-1; Ly73; orv; protein-tyrosine kinase receptor flk-1; soluble vascular endothelial growth factor receptor 2; sVEGFR-2; vascular endothelial growth factor receptor 2; vascular endothelial growth factor receptor- 2; vascular endothelial growth factor receptor-2; vascular endothelial growth factor receptor-3; VEGF; VEGF receptor-2; VEGFR; VEGFR-2; VEGFR2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39576,093,487 - 76,139,880 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl576,093,487 - 76,139,118 (-)EnsemblGRCm39 Ensembl
GRCm38575,932,827 - 75,979,072 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl575,932,827 - 75,978,458 (-)EnsemblGRCm38mm10GRCm38
MGSCv37576,329,290 - 76,374,453 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36576,214,962 - 76,260,125 (-)NCBIMGSCv36mm8
Celera573,218,468 - 73,263,674 (-)NCBICelera
Cytogenetic Map5C3.3NCBI
cM Map540.23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Lung Injury  (ISO)
adenocarcinoma  (ISO)
adhesions of uterus  (ISO)
allergic contact dermatitis  (ISO)
amyotrophic lateral sclerosis  (ISO)
angiosarcoma  (ISO)
Animal Mammary Neoplasms  (IMP)
arteriosclerosis  (ISO)
arteriovenous malformations of the brain  (ISO)
asthma  (IMP,ISO)
atherosclerosis  (IDA)
brain glioma  (ISO)
Brain Hypoxia-Ischemia  (ISO)
Brain Injuries  (ISO)
brain ischemia  (ISO)
breast angiosarcoma  (ISO)
breast cancer  (ISO)
breast carcinoma  (ISO)
Breast Neoplasms  (IMP,ISO)
cerebral cavernous malformation  (ISO)
Cerebral Hemorrhage  (ISO)
Choroidal Neovascularization  (IMP,ISO)
chronic obstructive pulmonary disease  (ISO)
colitis  (ISO)
colon carcinoma  (IMP,ISO)
Colonic Neoplasms  (IEP)
colorectal adenocarcinoma  (ISO)
colorectal cancer  (ISO)
Colorectal Neoplasms  (ISO)
congenital disorder of glycosylation type IIk  (ISO)
contact dermatitis  (IMP)
corneal neovascularization  (IDA,IMP)
Coronary Disease  (ISO)
Crohn's disease  (ISO)
cystitis  (ISO)
decubitus ulcer  (ISO)
Diabetic Nephropathies  (ISO)
diffuse scleroderma  (ISO)
Endometrial Neoplasms  (ISO)
Endometrioid Carcinomas  (ISO)
endometriosis  (ISO)
Esophageal Neoplasms  (ISO)
esophagus adenocarcinoma  (ISO)
Experimental Autoimmune Encephalomyelitis  (IMP)
Experimental Colitis  (IEP)
Experimental Diabetes Mellitus  (IEP,ISO)
Experimental Liver Neoplasms  (ISO)
Experimental Mammary Neoplasms  (ISO)
Eye Neoplasms  (ISO)
gastrointestinal stromal tumor  (ISO)
glioblastoma  (ISO)
Hand-Foot Syndrome  (ISO)
hemangiopericytoma  (ISO)
hepatoblastoma  (ISO)
hepatocellular carcinoma  (ISO)
herpes simplex virus keratitis  (IDA,IEP)
high grade glioma  (IMP,ISO)
High Myopia  (ISO)
Hirschsprung's disease  (ISO)
hydrophthalmos  (IMP)
hypertension  (ISO)
impotence  (ISO)
Infantile Capillary Hemangioma  (ISO)
inverted papilloma  (ISO)
Kidney Neoplasms  (IMP)
Kuhnt-Junius degeneration  (ISO)
Lathyrism  (ISO)
limited scleroderma  (ISO)
liver cirrhosis  (ISO)
lung carcinoma  (IMP)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (IMP,ISO)
lymphangioma  (ISO)
Lymphatic Metastasis  (IMP)
macular degeneration  (IMP,ISO)
macular retinal edema  (ISO)
melanoma  (IMP,ISO)
myocardial infarction  (ISO)
Myocardial Ischemia  (ISO)
Nasal Polyps  (ISO)
nasopharynx carcinoma  (ISO)
Neoplasm Metastasis  (ISO)
Neovascularization, Pathologic  (ISO)
Neuralgia  (ISO)
neurilemmoma  (ISO)
neurofibrosarcoma  (IMP)
osteochondrodysplasia  (ISO)
Otitis Media with Effusion  (ISO)
ovarian hyperstimulation syndrome  (ISO)
Ovarian Neoplasms  (ISO)
Oxygen-Induced Retinopathy  (ISO)
pancreatic cancer  (ISO)
pancreatic carcinoma  (ISO)
primary ovarian insufficiency  (ISO)
prostate adenocarcinoma  (ISO)
prostate cancer  (ISO)
prostatic hypertrophy  (ISO)
psoriasis  (IMP,ISO)
pterygium  (ISO)
renal cell carcinoma  (IMP)
Reperfusion Injury  (ISO)
retinal telangiectasia  (ISO)
retinopathy of prematurity  (IMP,ISO)
salivary gland carcinoma  (ISO)
sarcoma  (ISO)
schizophrenia  (ISO)
Seasonal Allergic Rhinitis  (ISO)
Spinal Cord Injuries  (ISO)
squamous cell carcinoma  (IMP)
stomach cancer  (ISO)
Stroke  (ISO)
systemic scleroderma  (ISO)
temporal lobe epilepsy  (ISO)
teratoma  (ISO)
tetralogy of Fallot  (ISO)
thyroid gland carcinoma  (ISO)
tongue squamous cell carcinoma  (IMP)
transitional cell carcinoma  (ISO)
Transplant Rejection  (IMP)
Tufted Angioma  (ISO)
type 2 diabetes mellitus  (ISO)
ulcerative colitis  (ISO)
uremia  (ISO)
urinary bladder cancer  (ISO)
Uterine Cervical Neoplasms  (ISO)
uveal melanoma  (ISO)
Venous Thrombosis  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(S)-naringenin  (ISO)
(S)-nicotine  (ISO)
1,1-dichloroethene  (EXP)
1,2,4-trimethylbenzene  (ISO)
1,2-dimethylhydrazine  (EXP)
1,4-benzoquinone  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,3-Bis(3-hydroxybenzyl)butane-1,4-diol  (EXP)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
2-tert-butylhydroquinone  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO)
3,3',5,5'-tetraiodothyroacetic acid  (ISO)
3,3'-diindolylmethane  (ISO)
3,5,6-trichloro-2-pyridinol  (EXP)
3,5,6-trichloropyridine-2-one  (EXP)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-methylcholanthrene  (EXP)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (EXP)
5-azacytidine  (ISO)
5-fluorouracil  (EXP)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP,ISO)
6-propyl-2-thiouracil  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
amiodarone  (ISO)
amitrole  (ISO)
andrographolide  (ISO)
apigenin  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
aspartame  (ISO)
Auriculasin  (ISO)
baicalin  (ISO)
belinostat  (ISO)
benzbromarone  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzylpenicillin  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bisdemethoxycurcumin  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
bisphenol F  (EXP)
bortezomib  (ISO)
cadmium atom  (ISO)
calcidiol  (ISO)
calcitriol  (ISO)
calcium atom  (EXP,ISO)
calcium silicate  (ISO)
calcium(0)  (EXP,ISO)
carbon nanotube  (EXP)
chlorpyrifos  (EXP)
choline  (EXP)
clofibrate  (EXP,ISO)
clofibric acid  (ISO)
clozapine  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cordycepin  (ISO)
corticosterone  (EXP)
coumarin  (ISO)
crocidolite asbestos  (ISO)
curcumin  (EXP,ISO)
Curcumol  (EXP,ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cypermethrin  (EXP)
D-glucose  (EXP,ISO)
deguelin  (ISO)
demethoxycurcumin  (ISO)
desferrioxamine B  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
diethylstilbestrol  (ISO)
dihydrogen  (ISO)
dioscin  (ISO)
dioxygen  (EXP,ISO)
diprotium  (ISO)
diquat  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
embelin  (ISO)
enalapril  (ISO)
Enterolactone  (EXP)
entinostat  (EXP,ISO)
ethanol  (EXP)
ethyl trans-caffeate  (ISO)
flutamide  (ISO)
folic acid  (EXP)
fructose  (ISO)
fumonisin B1  (EXP)
furosemide  (ISO)
Fusaproliferin  (ISO)
galaxolide  (ISO)
gefitinib  (EXP)
genistein  (EXP,ISO)
gentamycin  (ISO)
geraniol  (EXP)
glafenine  (ISO)
glucose  (EXP,ISO)
glycidol  (ISO)
glyphosate  (ISO)
haloperidol  (ISO)
harmaline  (EXP)
hexachlorobenzene  (ISO)
indoles  (ISO)
isoprenaline  (EXP)
kaempferol  (ISO)
L-ascorbic acid  (ISO)
L-ethionine  (ISO)
L-methionine  (EXP)
lead diacetate  (EXP)
lipopolysaccharide  (ISO)
lithium chloride  (EXP)
losartan  (ISO)
medroxyprogesterone acetate  (ISO)
melatonin  (ISO)
melittin  (ISO)
methimazole  (ISO)
methoxychlor  (ISO)
methyl caffeate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
microcystin-LR  (EXP,ISO)
mifepristone  (EXP)
MK-2206  (ISO)
monocrotaline  (EXP)
monosodium L-glutamate  (ISO)
Morroniside  (ISO)
N-acetyl-L-cysteine  (ISO)
N-acetylsphingosine  (EXP,ISO)
N-ethyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (ISO)
nickel atom  (EXP)
nicotine  (ISO)
nicotinic acid  (EXP)
nitrofen  (ISO)
O-methyleugenol  (ISO)
omeprazole  (EXP,ISO)
orantinib  (ISO)
orlistat  (ISO)
oxaliplatin  (ISO)
oxybenzone  (EXP)
ozone  (EXP,ISO)
p-menthan-3-ol  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
PCB138  (EXP)
PD123319  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
phenylephrine  (ISO)
phenytoin  (EXP)
phosgene  (EXP,ISO)
pirfenidone  (EXP,ISO)
pirinixic acid  (EXP,ISO)
platycodin D  (ISO)
ponatinib  (ISO)
Ponicidin  (ISO)
potassium dichromate  (EXP)
progesterone  (ISO)
quercetin  (ISO)
quercitrin  (ISO)
quinacrine  (ISO)
quinazolines  (ISO)
resveratrol  (ISO)
Rhein  (ISO)
riddelliine  (ISO)
rosuvastatin calcium  (EXP)
rotenone  (ISO)
saccharin  (EXP)
sarpogrelate  (EXP)
SB 431542  (ISO)
semaxanib  (ISO)
silicon dioxide  (EXP)
simvastatin  (EXP,ISO)
sodium arsenite  (ISO)
sorafenib  (ISO)
sphingosine 1-phosphate  (ISO)
streptozocin  (EXP,ISO)
sulfadimethoxine  (ISO)
sunitinib  (ISO)
superoxide  (ISO)
tanespimycin  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
thalidomide  (ISO)
thioacetamide  (ISO)
thyroxine  (ISO)
titanium dioxide  (EXP)
toluene  (ISO)
topotecan  (ISO)
trichloroethene  (EXP,ISO)
triclosan  (ISO)
triptonide  (EXP)
troglitazone  (EXP)
trovafloxacin  (EXP)
tunicamycin  (EXP)
undecane  (ISO)
urea  (ISO)
urethane  (EXP)
valproic acid  (EXP,ISO)
valsartan  (ISO)
vinclozolin  (ISO)
vorinostat  (ISO)
WIN 55212-2  (EXP)
zinc atom  (ISO)
zinc sulfate  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (IBA)
blood vessel endothelial cell differentiation  (IMP,TAS)
brain-derived neurotrophic factor receptor signaling pathway  (IEA)
branching involved in blood vessel morphogenesis  (IEA,ISO)
branching morphogenesis of an epithelial tube  (IMP)
calcium ion homeostasis  (IDA)
cell fate commitment  (IMP)
cell migration  (IBA,IGI)
cell migration involved in sprouting angiogenesis  (IMP)
cell surface receptor protein tyrosine kinase signaling pathway  (IBA)
cellular response to hydrogen sulfide  (IEA,ISO)
cellular response to vascular endothelial growth factor stimulus  (ISO,ISS)
collagen-activated tyrosine kinase receptor signaling pathway  (IEA)
embryonic hemopoiesis  (IMP)
endocardium development  (IMP)
endochondral bone growth  (ISO)
endothelial cell differentiation  (IBA,IDA,IMP,TAS)
endothelial tube morphogenesis  (ISO)
endothelium development  (IMP)
ephrin receptor signaling pathway  (IEA)
epidermal growth factor receptor signaling pathway  (IEA)
epithelial cell maturation  (IMP)
epithelial cell proliferation  (IMP)
fibroblast growth factor receptor signaling pathway  (IEA)
hemopoiesis  (IMP)
hepatocyte growth factor receptor signaling pathway  (IEA)
insulin receptor signaling pathway  (IEA)
insulin-like growth factor receptor signaling pathway  (IEA)
Kit signaling pathway  (IEA)
lung alveolus development  (IMP)
lung development  (IMP)
lymph vessel development  (IGI)
macrophage colony-stimulating factor signaling pathway  (IEA)
male gonad development  (ISO)
mesenchymal cell proliferation  (IMP)
negative regulation of endothelial cell apoptotic process  (ISO,ISS)
negative regulation of gene expression  (IEA,ISO)
negative regulation of neuron apoptotic process  (IGI,ISO)
negative regulation of systemic arterial blood pressure  (ISO)
neuron projection morphogenesis  (ISO)
ovarian follicle development  (IMP)
peptidyl-tyrosine autophosphorylation  (IDA)
peptidyl-tyrosine phosphorylation  (ISO,ISS)
platelet-derived growth factor receptor-alpha signaling pathway  (IEA)
platelet-derived growth factor receptor-beta signaling pathway  (IEA)
positive regulation of angiogenesis  (IBA,IDA,ISO)
positive regulation of blood vessel endothelial cell migration  (ISO)
positive regulation of BMP signaling pathway  (IDA)
positive regulation of calcium-mediated signaling  (ISO)
positive regulation of cell migration  (IBA,ISO)
positive regulation of cell migration involved in sprouting angiogenesis  (IEA,ISO)
positive regulation of cell population proliferation  (IBA,ISO)
positive regulation of cytosolic calcium ion concentration  (ISO)
positive regulation of endothelial cell chemotaxis  (IEA,ISO)
positive regulation of endothelial cell migration  (ISO,TAS)
positive regulation of endothelial cell proliferation  (ISO,ISS)
positive regulation of epithelial cell proliferation  (IMP)
positive regulation of ERK1 and ERK2 cascade  (IEA,ISO)
positive regulation of focal adhesion assembly  (IEA,ISO)
positive regulation of long-term neuronal synaptic plasticity  (ISO)
positive regulation of macroautophagy  (ISO)
positive regulation of MAPK cascade  (ISO,ISS)
positive regulation of mesenchymal cell proliferation  (IMP)
positive regulation of mitochondrial depolarization  (ISO)
positive regulation of mitochondrial fission  (ISO)
positive regulation of neurogenesis  (ISO)
positive regulation of nitric oxide-cGMP mediated signal transduction  (ISS)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO,ISS)
positive regulation of positive chemotaxis  (IEA,ISO)
positive regulation of protein phosphorylation  (ISO,ISS)
positive regulation of stem cell proliferation  (IMP)
positive regulation of TOR signaling  (ISO)
positive regulation of vascular endothelial growth factor receptor signaling pathway  (TAS)
positive regulation of vasculogenesis  (IMP)
post-embryonic camera-type eye morphogenesis  (IGI)
protein autophosphorylation  (ISO,ISS)
regulation of bone development  (IMP)
regulation of cell shape  (IEA,ISO)
regulation of endothelial cell proliferation  (TAS)
regulation of hematopoietic progenitor cell differentiation  (IMP)
regulation of MAPK cascade  (IBA)
response to axon injury  (ISO)
response to hypoxia  (ISO)
response to oxygen levels  (ISO)
response to xenobiotic stimulus  (ISO)
semaphorin-plexin signaling pathway  (IGI)
stem cell proliferation  (IMP)
surfactant homeostasis  (IMP)
vascular endothelial growth factor receptor signaling pathway  (IDA,ISO,ISS)
vascular endothelial growth factor receptor-1 signaling pathway  (IEA)
vascular endothelial growth factor receptor-2 signaling pathway  (ISO,ISS)
vascular endothelial growth factor signaling pathway  (IEA,ISO)
vascular wound healing  (IEA,ISO)
vasculogenesis  (IMP)
vasodilation  (ISO)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal allantois morphology  (IAGP)
abnormal angiogenesis  (IAGP)
abnormal basement membrane morphology  (IAGP)
abnormal blood vessel morphology  (IAGP)
abnormal blood-brain barrier function  (IAGP)
abnormal bone structure  (IAGP)
abnormal brain vasculature morphology  (IAGP)
abnormal cornea morphology  (IAGP)
abnormal coronary artery morphology  (IAGP)
abnormal cranial neural crest cell migration  (IAGP)
abnormal definitive hematopoiesis  (IAGP)
abnormal dorsal aorta morphology  (IAGP)
abnormal embryo development  (IAGP)
abnormal embryonic hematopoiesis  (IAGP)
abnormal embryonic tissue morphology  (IAGP)
abnormal extraembryonic mesoderm development  (IAGP)
abnormal heart development  (IAGP)
abnormal induced retina neovascularization  (IAGP)
abnormal interventricular septum morphology  (IAGP)
abnormal liver development  (IAGP)
abnormal long bone diaphysis morphology  (IAGP)
abnormal lung morphology  (IAGP)
abnormal lymphangiogenesis  (IAGP)
abnormal lymphatic vessel morphology  (IAGP)
abnormal lymphatic vessel smooth muscle morphology  (IAGP)
abnormal mandibular prominence morphology  (IAGP)
abnormal nervous system development  (IAGP)
abnormal placental labyrinth vasculature morphology  (IAGP)
abnormal retina vasculature morphology  (IAGP)
abnormal second pharyngeal arch morphology  (IAGP)
abnormal skeleton development  (IAGP)
abnormal trabecula carnea morphology  (IAGP)
abnormal trigeminal ganglion morphology  (IAGP)
abnormal vascular branching morphogenesis  (IAGP)
abnormal vascular development  (IAGP)
abnormal vascular endothelial cell differentiation  (IAGP)
abnormal vascular endothelial cell migration  (IAGP)
abnormal vasculogenesis  (IAGP)
abnormal vein morphology  (IAGP)
abnormal visceral yolk sac morphology  (IAGP)
abnormal vitelline vascular remodeling  (IAGP)
abnormal vitelline vasculature morphology  (IAGP)
absent atrioventricular cushions  (IAGP)
absent fourth pharyngeal arch  (IAGP)
absent organized vascular network  (IAGP)
absent third pharyngeal arch  (IAGP)
absent visceral yolk sac blood islands  (IAGP)
absent vitelline blood vessels  (IAGP)
congestive heart failure  (IAGP)
decreased body size  (IAGP)
decreased embryo size  (IAGP)
decreased total retina thickness  (IAGP)
embryo tissue necrosis  (IAGP)
embryonic growth arrest  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
embryonic lethality, complete penetrance  (IAGP)
enlarged lymphatic vessel  (IAGP)
failure of chorioallantoic fusion  (IAGP)
heart hemorrhage  (IAGP)
hemorrhage  (IAGP)
impaired cranial neural crest cell differentiation  (IAGP)
impaired hematopoiesis  (IAGP)
increased angiogenesis  (IAGP)
increased bone mass  (IAGP)
increased susceptibility to injury  (IAGP)
internal hemorrhage  (IAGP)
intracranial hemorrhage  (IAGP)
lethality throughout fetal growth and development, complete penetrance  (IAGP)
lymphatic vessel hyperplasia  (IAGP)
no abnormal phenotype detected  (IAGP)
pale yolk sac  (IAGP)
pallor  (IAGP)
pericardial effusion  (IAGP)
persistence of hyaloid vascular system  (IAGP)
prenatal lethality  (IAGP)
prenatal lethality, incomplete penetrance  (IAGP)
small heart  (IAGP)
spinal hemorrhage  (IAGP)
thin retina inner plexiform layer  (IAGP)
vascular smooth muscle hypoplasia  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Inhibition of angiogenesis by blocking activation of the vascular endothelial growth factor receptor 2 leads to decreased growth of neurogenic sarcomas. Angelov L, etal., Cancer Res. 1999 Nov 1;59(21):5536-41.
2. Prognostic importance of vascular endothelial growth factor and its receptors in the uterine sarcoma. Arita S, etal., Int J Gynecol Cancer. 2005 Mar-Apr;15(2):329-36.
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22. Arteriogenic erectile dysfunction alters protein expression within the cavernosal tissue in an animal model. De Young L, etal., J Sex Med. 2005 Mar;2(2):199-206.
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30. Differential expression of vascular endothelial growth factor implies the limbal origin of pterygia. Gebhardt M, etal., Ophthalmology. 2005 Jun;112(6):1023-30.
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37. Inhibition of VEGFR2 prevents DMBA-induced mammary tumor formation. Heffelfinger SC, etal., Lab Invest. 2004 Aug;84(8):989-98.
38. Histological and transcriptional study of angiogenesis and lymphangiogenesis in uninvolved skin, acute pinpoint lesions and established psoriasis plaques: an approach of vascular development chronology in psoriasis. Henno A, etal., J Dermatol Sci. 2010 Mar;57(3):162-9. doi: 10.1016/j.jdermsci.2009.12.006. Epub 2010 Jan 7.
39. Polymorphisms in Vascular Endothelial Growth Factor Receptor 2 Are Associated with Better Response Rates to Ranibizumab Treatment in Age-related Macular Degeneration. Hermann MM, etal., Ophthalmology. 2013 Dec 20. pii: S0161-6420(13)01056-7. doi: 10.1016/j.ophtha.2013.10.047.
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77. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
78. MGDs mouse GO annotations MGD data from the GO Consortium
79. MGD IEA MGD IEA
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97. VEGF and VEGFR-2 immunohistochemistry in human melanocytic naevi and cutaneous melanomas. Pisacane AM and Risio M, Melanoma Res. 2005 Feb;15(1):39-43.
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100. Soluble Vascular Endothelial Growth Factor Receptor-2 as a Predictive Factor for Progression of Illness in Chronic Liver Diseases and Hepatocellular Carcinoma. Ratnasari N, etal., Kobe J Med Sci. 2015 Dec 18;61(3):E89-96.
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104. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
105. Cytokine levels correlate with immune cell infiltration after anti-VEGF therapy in preclinical mouse models of breast cancer. Roland CL, etal., PLoS One. 2009 Nov 3;4(11):e7669.
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117. Nine Genes Mediate the Therapeutic Effects of Iodine-131 Radiotherapy in Thyroid Carcinoma Patients. Shuwen H, etal., Dis Markers. 2020 Jun 16;2020:9369341. doi: 10.1155/2020/9369341. eCollection 2020.
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131. Anti-vascular endothelial growth factor receptor-2 (Flk-1/KDR) antibody suppresses contact hypersensitivity. Watanabe H, etal., Exp Dermatol. 2004 Nov;13(11):671-81.
132. Inhibition of platelet-derived growth factor promotes pericyte loss and angiogenesis in ischemic retinopathy. Wilkinson-Berka JL, etal., Am J Pathol. 2004 Apr;164(4):1263-73.
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PMID:31790655   PMID:31836710   PMID:31868583   PMID:31868584   PMID:31870435   PMID:31902568   PMID:31907354   PMID:31923399   PMID:31943281   PMID:31980946   PMID:32027977   PMID:32045685  
PMID:32046118   PMID:32059772   PMID:32112176   PMID:32141129   PMID:32259484   PMID:32312382   PMID:32369449   PMID:32369453   PMID:32415669   PMID:32423231   PMID:32521258   PMID:32565279  
PMID:32692983   PMID:32737287   PMID:32783108   PMID:32798765   PMID:32880713   PMID:32951265   PMID:33060561   PMID:33106502   PMID:33130914   PMID:33158964   PMID:33215738   PMID:33255657  
PMID:33274003   PMID:33372189   PMID:33420489   PMID:33454424   PMID:33500353   PMID:33536212   PMID:33568475   PMID:33619517   PMID:33730615   PMID:33752600   PMID:33830085   PMID:33910825  
PMID:33929320   PMID:34000274   PMID:34010630   PMID:34035268   PMID:34148274   PMID:34184034   PMID:34267243   PMID:34321999   PMID:34336823   PMID:34338296   PMID:34356686   PMID:34395414  
PMID:34670814   PMID:34671097   PMID:34741805   PMID:34774518   PMID:34850819   PMID:34861214   PMID:34890862   PMID:34927678   PMID:34999110   PMID:35050301   PMID:35108221   PMID:35144597  
PMID:35163801   PMID:35246514   PMID:35264563   PMID:35266581   PMID:35297995   PMID:35319724   PMID:35364055   PMID:35377412   PMID:35388142   PMID:35613877   PMID:35649376   PMID:35709757  
PMID:35747128   PMID:35786324   PMID:35894043   PMID:35918150   PMID:36046192   PMID:36178184   PMID:36196867   PMID:36216515   PMID:36239412   PMID:36254231   PMID:36318802   PMID:36347256  
PMID:36384284   PMID:36418889   PMID:36596806   PMID:36740182   PMID:36810619   PMID:36883729   PMID:37037405   PMID:37117774   PMID:37381118   PMID:37454290   PMID:37534464   PMID:37636062  
PMID:37643615   PMID:37680049   PMID:37725078   PMID:37818607   PMID:37910508   PMID:37948457   PMID:38029740   PMID:38242992   PMID:38374152   PMID:38382296   PMID:38491522   PMID:38834586  
PMID:38906145   PMID:39001875   PMID:39360476   PMID:39524353   PMID:39612246   PMID:39629666  


Genomics

Comparative Map Data
Kdr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39576,093,487 - 76,139,880 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl576,093,487 - 76,139,118 (-)EnsemblGRCm39 Ensembl
GRCm38575,932,827 - 75,979,072 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl575,932,827 - 75,978,458 (-)EnsemblGRCm38mm10GRCm38
MGSCv37576,329,290 - 76,374,453 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36576,214,962 - 76,260,125 (-)NCBIMGSCv36mm8
Celera573,218,468 - 73,263,674 (-)NCBICelera
Cytogenetic Map5C3.3NCBI
cM Map540.23NCBI
KDR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38455,078,481 - 55,125,595 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl455,078,481 - 55,125,595 (-)EnsemblGRCh38hg38GRCh38
GRCh37455,944,648 - 55,991,762 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36455,639,406 - 55,686,519 (-)NCBINCBI36Build 36hg18NCBI36
Build 34455,785,576 - 55,832,690NCBI
Celera453,446,341 - 53,493,673 (-)NCBICelera
Cytogenetic Map4q12NCBI
HuRef451,893,013 - 51,940,346 (-)NCBIHuRef
CHM1_1455,979,683 - 56,027,015 (-)NCBICHM1_1
T2T-CHM13v2.0458,566,962 - 58,614,067 (-)NCBIT2T-CHM13v2.0
Kdr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81432,572,031 - 32,615,204 (+)NCBIGRCr8
mRatBN7.21432,217,871 - 32,261,018 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1432,217,871 - 32,261,018 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1432,577,934 - 32,621,098 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01433,885,873 - 33,929,041 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01432,370,973 - 32,414,143 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01434,727,677 - 34,787,127 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1434,727,623 - 34,787,183 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01434,557,361 - 34,618,112 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1431,512,534 - 31,554,989 (+)NCBICelera
Cytogenetic Map14p11NCBI
Kdr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544715,810,815 - 15,853,583 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544715,810,816 - 15,851,702 (+)NCBIChiLan1.0ChiLan1.0
KDR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2374,668,536 - 74,715,699 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1474,872,484 - 74,922,704 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0468,813,894 - 68,861,018 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1475,377,847 - 75,424,927 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl475,377,375 - 75,427,109 (+)Ensemblpanpan1.1panPan2
KDR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11347,442,861 - 47,484,574 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1347,442,764 - 47,485,042 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1347,400,610 - 47,442,293 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01348,053,730 - 48,095,387 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1348,053,595 - 48,095,437 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11347,729,487 - 47,771,112 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01347,258,117 - 47,299,735 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01348,206,381 - 48,248,022 (-)NCBIUU_Cfam_GSD_1.0
Kdr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528528,716,920 - 28,760,830 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648217,538,864 - 17,581,002 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648217,537,697 - 17,581,320 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KDR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl841,809,122 - 41,856,336 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1841,809,116 - 41,856,379 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2843,919,330 - 43,966,984 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KDR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1713,435,059 - 13,482,236 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl713,435,096 - 13,482,771 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606614,207,326 - 14,254,753 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kdr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476114,330,489 - 14,379,051 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476114,330,224 - 14,380,680 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Kdr
2409 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:678
Count of miRNA genes:408
Interacting mature miRNAs:493
Transcripts:ENSMUST00000113516, ENSMUST00000149573
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301843Listr1_mlisteriosis resistance 1 (mouse)Not determined56024608194246203Mouse
10043993Hbnr10_mHeligmosomoides bakeri nematode resistance 10 (mouse)Not determined572418876106419011Mouse
27226719Tibw6_mtibia width 6, proximal, 16 week (mouse)572857343139985755Mouse
4140990Lgq6_mlate growth QTL 6 (mouse)Not determined32133234100777931Mouse
1301010ahl2_mage related hearing loss 2 (mouse)Not determined56265056896650688Mouse
11041899Lmr24a_mleishmaniasis resistance 24a (mouse)552694462107321041Mouse
14746981Manh57_mmandible shape 57 (mouse)54716974281169742Mouse
1301524Lmb2_mlupus in MRL and B6 F2 cross (mouse)Not determined537581488112465722Mouse
25314315Mlh1fc4_mMLH1 foci count 4 (mouse)574460661132528839Mouse
10045972Tir5_mtrypanosome infection response 5 (mouse)Not determined563705442104387065Mouse
4142064Tmc1m4_mTmc1 modifier 4 (mouse)Not determined554500177127001072Mouse
1301698Pcfm4_mperiosteal circumference and femur length 4 (mouse)Not determined54458584378585965Mouse
4142317Rgcs1_mretinal ganglion cell susceptible 1 (mouse)Not determined55388334108762627Mouse
4141219W10q16_mweight 10 weeks QTL 16 (mouse)Not determined32133234100777931Mouse
12904740M1fscn2_mmodifier 1 of Fscn2 (mouse)566529661100529661Mouse
10043962Obq27_mobesity QTL 27 (mouse)Not determined55628565590285655Mouse
4142428Modvl1_mmodifier of vacuolated lens 1 (mouse)Not determined6265056896650688Mouse
1357431Cia27_mcollagen induced arthritis 27 (mouse)Not determined575315348120018629Mouse
11040589Lmr3a_mleishmaniasis resistance 3a (mouse)55960280193602980Mouse
11040590Lmr3b_mleishmaniasis resistance 3b (mouse)55960280193602980Mouse
11040591Lmr3c_mleishmaniasis resistance 3c (mouse)55960280193602980Mouse
12904739M2fscn2_mmodifier 2 of FSCN2 (mouse)566529661100529661Mouse
1301243Bmd2_mbone mineral density 2 (mouse)Not determined555388334100455525Mouse
13207584Mwmlpt4_mMorris water maze latency to platform, training, 4 (mouse)54632260680322606Mouse
11041665Lmr24_mleishmaniasis resistance 24 (mouse)552694462107321041Mouse
13207588Mwmlpa4_mMorris water maze latency to platform, all, 4 (mouse)54632260680322606Mouse
1301693Sle6_msystemic lupus erythematosus susceptibility 6 (mouse)Not determined5889069387841837Mouse
11049560Lmr24d_mleishmaniasis resistance 24d (mouse)56437487798374996Mouse
26884395Humsd2_mhumerus midshaft diameter 2, 10 week (mouse)570057343132528839Mouse
13464248Ahl13_mage related hearing loss, early onset 13 (mouse)55564587489645995Mouse
11252124Modvl6_mmodifier of vacuolated lens 6 (mouse)56265056896650688Mouse
13464250Ahl15_mage related hearing loss, early onset 15 (mouse)56265056896650688Mouse
11040592Lmr3d_mleishmaniasis resistance 3d (mouse)55960280193602980Mouse
11341716Rvfs3_mRift Valley fever susceptibility 3 (mouse)526441234138455402Mouse
13464247Ahl14_mage related hearing loss, early onset 14 (mouse)56040306294403160Mouse
10412069Desp3_mdespair 3 (mouse)Not determined57293268477246203Mouse
4141124Dshv2_mdorsal hippocampal volume 2 (mouse)Not determined57531534898019803Mouse
10044005Ahl7_mage related hearing loss 7 (mouse)Not determined55833050292330641Mouse
13506928Recrq8_mrecombination rate in male meiosis QTL 8 (mouse)574460661132528839Mouse

Markers in Region
S53103  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38575,934,049 - 75,934,138UniSTSGRCm38
MGSCv37576,330,074 - 76,330,163UniSTSGRCm37
Celera573,219,252 - 73,219,341UniSTS
Cytogenetic Map5C3.3UniSTS
Whitehead/MRC_RH51063.49UniSTS
PMC151926P3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38575,933,504 - 75,934,032UniSTSGRCm38
MGSCv37576,329,529 - 76,330,057UniSTSGRCm37
Celera573,218,707 - 73,219,235UniSTS
Cytogenetic Map5C3.3UniSTS
Kdr  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv37576,330,137 - 76,330,320UniSTSGRCm37
MGSCv37576,329,308 - 76,329,691UniSTSGRCm37
MGSCv37576,374,265 - 76,374,399UniSTSGRCm37
Celera573,218,486 - 73,218,869UniSTS
Celera573,219,315 - 73,219,498UniSTS
Celera573,263,486 - 73,263,620UniSTS
Cytogenetic Map5C3.3UniSTS
cM Map542.0UniSTS
cM Map542.0UniSTS
cM Map542.0UniSTS
cM Map542.0UniSTS
cM Map542.0UniSTS
Kdr  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5C3.3UniSTS
Kdr  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38575,934,112 - 75,934,295UniSTSGRCm38
MGSCv37576,330,137 - 76,330,320UniSTSGRCm37
Celera573,219,315 - 73,219,498UniSTS
Cytogenetic Map5C3.3UniSTS
cM Map542.0UniSTS
Kdr  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38575,978,240 - 75,978,374UniSTSGRCm38
MGSCv37576,374,265 - 76,374,399UniSTSGRCm37
Celera573,263,486 - 73,263,620UniSTS
Cytogenetic Map5C3.3UniSTS
cM Map542.0UniSTS
Kdr  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5C3.3UniSTS
cM Map542.0UniSTS
Kdr  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38575,933,283 - 75,933,666UniSTSGRCm38
MGSCv37576,329,308 - 76,329,691UniSTSGRCm37
Celera573,218,486 - 73,218,869UniSTS
Cytogenetic Map5C3.3UniSTS
cM Map542.0UniSTS
Kdr  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5C3.3UniSTS
cM Map542.0UniSTS
Kdr  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5C3.3UniSTS
Kdr  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5C3.3UniSTS
Kdr  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5C3.3UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001363216 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001403141 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001403142 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001403143 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001403144 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_010612 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_175357 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_175358 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC124615 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC134903 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC160723 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF061804 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF153058 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK031739 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK054510 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK141938 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC020530 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466524 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU884114 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S53103 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X59397 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X70842 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X89777 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000113516   ⟹   ENSMUSP00000109144
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl576,093,487 - 76,139,118 (-)Ensembl
GRCm38.p6 Ensembl575,932,827 - 75,978,458 (-)Ensembl
Ensembl Acc Id: ENSMUST00000149573
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl576,121,904 - 76,139,118 (-)Ensembl
GRCm38.p6 Ensembl575,961,244 - 75,978,458 (-)Ensembl
Ensembl Acc Id: ENSMUST00000202473
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl576,118,025 - 76,139,118 (-)Ensembl
GRCm38.p6 Ensembl575,957,365 - 75,978,458 (-)Ensembl
RefSeq Acc Id: NM_001363216   ⟹   NP_001350145
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39576,118,025 - 76,139,115 (-)NCBI
GRCm38575,957,365 - 75,978,455 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001403141   ⟹   NP_001390070
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39576,093,487 - 76,139,880 (-)NCBI
RefSeq Acc Id: NM_001403142   ⟹   NP_001390071
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39576,093,487 - 76,139,115 (-)NCBI
RefSeq Acc Id: NM_001403143   ⟹   NP_001390072
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39576,093,487 - 76,139,115 (-)NCBI
RefSeq Acc Id: NM_001403144   ⟹   NP_001390073
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39576,093,487 - 76,139,880 (-)NCBI
RefSeq Acc Id: NM_010612   ⟹   NP_034742
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39576,093,487 - 76,139,115 (-)NCBI
GRCm38575,932,827 - 75,978,455 (-)NCBI
MGSCv37576,329,290 - 76,374,453 (-)RGD
Celera573,218,468 - 73,263,674 (-)RGD
cM Map5 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_175357
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39576,093,487 - 76,139,115 (-)NCBI
RefSeq Acc Id: NR_175358
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39576,093,487 - 76,139,115 (-)NCBI
RefSeq Acc Id: NP_034742   ⟸   NM_010612
- Peptide Label: isoform 1 precursor
- UniProtKB: P35918 (UniProtKB/Swiss-Prot),   C5H7S5 (UniProtKB/Swiss-Prot),   Q8VCD0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001350145   ⟸   NM_001363216
- Peptide Label: isoform 2 precursor
Ensembl Acc Id: ENSMUSP00000109144   ⟸   ENSMUST00000113516
RefSeq Acc Id: NP_001390073   ⟸   NM_001403144
- Peptide Label: isoform 5
RefSeq Acc Id: NP_001390070   ⟸   NM_001403141
- Peptide Label: isoform 1 precursor
- UniProtKB: P35918 (UniProtKB/Swiss-Prot),   C5H7S5 (UniProtKB/Swiss-Prot),   Q8VCD0 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: NP_001390072   ⟸   NM_001403143
- Peptide Label: isoform 4 precursor
RefSeq Acc Id: NP_001390071   ⟸   NM_001403142
- Peptide Label: isoform 3 precursor
Protein Domains
Ig-like   Ig-like C2-type   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P35918-F1-model_v2 AlphaFold P35918 1-1345 view protein structure

Promoters
RGD ID:6886932
Promoter ID:EPDNEW_M6917
Type:multiple initiation site
Name:Kdr_1
Description:Mus musculus kinase insert domain protein receptor , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38575,978,455 - 75,978,515EPDNEW
RGD ID:6837761
Promoter ID:MM_KWN:42616
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Kidney,   Liver,   Lung
Transcripts:ENSMUST00000076072,   ENSMUST00000113516,   OTTMUST00000050512
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36576,374,181 - 76,374,681 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:96683 AgrOrtholog
Ensembl Genes ENSMUSG00000062960 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000113516 ENTREZGENE
  ENSMUST00000113516.2 UniProtKB/Swiss-Prot
  ENSMUST00000202473 ENTREZGENE
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot
  Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
InterPro Ig-like_dom UniProtKB/Swiss-Prot
  Ig-like_dom_sf UniProtKB/Swiss-Prot
  Ig-like_fold UniProtKB/Swiss-Prot
  Ig_I-set UniProtKB/Swiss-Prot
  Ig_sub UniProtKB/Swiss-Prot
  Ig_sub2 UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  RTK UniProtKB/Swiss-Prot
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot
  Tyr_kinase_AS UniProtKB/Swiss-Prot
  Tyr_kinase_cat_dom UniProtKB/Swiss-Prot
  Tyr_kinase_rcpt_3_CS UniProtKB/Swiss-Prot
  VEGFR-2_TMD UniProtKB/Swiss-Prot
  VEGFR1-3_5th UniProtKB/Swiss-Prot
  VEGFR1-3_N_Ig-like UniProtKB/Swiss-Prot
  VEGFR2_rcpt UniProtKB/Swiss-Prot
KEGG Report mmu:16542 UniProtKB/Swiss-Prot
MGD MGI:96683 ENTREZGENE
NCBI Gene 16542 ENTREZGENE
PANTHER TYROSINE-PROTEIN KINASE RECEPTOR UniProtKB/Swiss-Prot
  VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2 UniProtKB/Swiss-Prot
Pfam I-set UniProtKB/Swiss-Prot
  Ig_3 UniProtKB/Swiss-Prot
  Pkinase_Tyr UniProtKB/Swiss-Prot
  VEGFR-1-like_5th UniProtKB/Swiss-Prot
  VEGFR-1-like_Ig-like UniProtKB/Swiss-Prot
  VEGFR-2_TMD UniProtKB/Swiss-Prot
  VEGFR1-3_N_Ig-like UniProtKB/Swiss-Prot
PharmGKB KDR RGD
PhenoGen Kdr PhenoGen
PIRSF TyrPK_CSF1-R UniProtKB/Swiss-Prot
PRINTS VEGFRECEPTOR UniProtKB/Swiss-Prot
  VEGFRECEPTR2 UniProtKB/Swiss-Prot
PROSITE IG_LIKE UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_TYR UniProtKB/Swiss-Prot
  RECEPTOR_TYR_KIN_III UniProtKB/Swiss-Prot
SMART IGc2 UniProtKB/Swiss-Prot
  SM00409 UniProtKB/Swiss-Prot
  TyrKc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot
  SSF56112 UniProtKB/Swiss-Prot
UniProt C5H7S5 ENTREZGENE
  P35918 ENTREZGENE
  Q3UQZ6_MOUSE UniProtKB/TrEMBL
  Q8CD05_MOUSE UniProtKB/TrEMBL
  Q8VCD0 ENTREZGENE
  VGFR2_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary C5H7S5 UniProtKB/Swiss-Prot
  Q8VCD0 UniProtKB/Swiss-Prot