Ins2 (insulin II) - Rat Genome Database

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Gene: Ins2 (insulin II) Mus musculus
Symbol: Ins2
Name: insulin II
RGD ID: 10812
Description: Enables zinc ion binding activity. Involved in insulin processing. Acts upstream of with a positive effect on receptor internalization. Acts upstream of or within several processes, including intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; positive regulation of ERK1 and ERK2 cascade; and positive regulation of phosphorylation. Located in cytosol; nucleus; and secretory granule. Part of sno(s)RNA-containing ribonucleoprotein complex. Is active in extracellular space. Is expressed in several structures, including brain; extraembryonic component; gut; immune system; and testis. Used to study maturity-onset diabetes of the young; neonatal diabetes; permanent neonatal diabetes mellitus; type 1 diabetes mellitus; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in diabetic retinopathy; glucose metabolism disease (multiple); insulinoma; and pancreatic cancer. Orthologous to human INS (insulin).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: AA986540; In; Ins-2; InsII; insulin-2; Mod; Mody; Mody4; proinsulin
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm397142,232,393 - 142,233,463 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7142,232,393 - 142,297,118 (-)EnsemblGRCm39 Ensembl
GRCm387142,678,656 - 142,679,726 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7142,678,656 - 142,743,381 (-)EnsemblGRCm38mm10GRCm38
MGSCv377149,864,561 - 149,865,613 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367142,488,051 - 142,489,098 (-)NCBIMGSCv36mm8
Celera7142,434,985 - 142,436,037 (-)NCBICelera
Cytogenetic Map7F5NCBI
cM Map788.0NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
Acute Liver Failure  (ISO)
adenoma  (IEP)
Albuminuria  (EXP,ISO)
Alzheimer's disease  (ISO)
bipolar disorder  (ISO)
bladder disease  (ISO)
cardiac arrest  (ISO)
cholangiocarcinoma  (ISO)
cognitive disorder  (ISO)
congestive heart failure  (ISO)
cystic kidney disease  (ISO)
delta beta-thalassemia  (ISO)
developmental and epileptic encephalopathy  (ISO)
diabetes mellitus  (EXP,IAGP,ISO)
Diabetic Cardiomyopathies  (ISO)
diabetic ketoacidosis  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (EXP,ISO)
disease of metabolism  (ISO)
early infantile epileptic encephalopathy  (ISO)
Edema  (ISO)
Experimental Liver Cirrhosis  (ISO)
fatty liver disease  (ISO)
generalized dystonia  (ISO)
genetic disease  (ISO)
gestational diabetes  (ISO)
glucose intolerance  (ISO)
hepatitis  (ISO)
hepatocellular carcinoma  (ISO)
hyperglycemia  (EXP,ISO)
hyperinsulinism  (ISO)
Hyperkalemia  (ISO)
Hyperproinsulinemia  (ISO)
hypertension  (EXP,ISO)
Hypertriglyceridemia  (ISO)
hypertrophic cardiomyopathy  (ISO)
hyperuricemia  (ISO)
hypoglycemia  (ISO)
Hypoinsulinemia  (ISO)
hypokalemia  (ISO)
Hypotension  (ISO)
immunodeficiency 39  (ISO)
Insulin Resistance  (ISO)
insulinoma  (ISO)
kidney disease  (EXP)
kidney failure  (ISO)
Lewy body dementia  (ISO)
liver disease  (ISO)
maturity-onset diabetes of the young  (IAGP,ISO)
maturity-onset diabetes of the young type 1  (ISO)
maturity-onset diabetes of the young type 10  (ISO)
Memory Disorders  (ISO)
Metabolic Syndrome  (ISO)
Micronuclei, Chromosome-Defective  (ISO)
MPTP Poisoning  (ISO)
muscular disease  (ISO)
neonatal diabetes  (IAGP,ISO)
Neoplasm Invasiveness  (ISO)
neural tube defect  (ISO)
neuronal ceroid lipofuscinosis  (ISO)
non-alcoholic fatty liver disease  (ISO)
obesity  (ISO)
osteoarthritis  (ISO)
pancreatic cancer  (IDA,ISO)
pancreatic ductal carcinoma  (ISO)
pancreatitis  (ISO)
panic disorder  (ISO)
Paralysis  (ISO)
Paresthesia  (ISO)
Parkinson's disease  (ISO)
permanent neonatal diabetes mellitus  (IAGP,ISO)
Permanent Neonatal Diabetes Mellitus 4  (ISO)
Phelan-McDermid syndrome  (ISO)
polycystic ovary syndrome  (ISO)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
Rhabdomyolysis  (ISO)
Segawa Syndrome, Autosomal Recessive  (ISO)
Tachycardia  (ISO)
transient neonatal diabetes mellitus  (ISO)
type 1 diabetes mellitus  (EXP,IMP,ISO)
type 1 diabetes mellitus 2  (IAGP,ISO)
type 2 diabetes mellitus  (IAGP,ISO)
Type 2 Diabetes Mellitus 1  (ISO)
Ventricular Dysfunction, Left  (ISO)
Ventricular Fibrillation  (ISO)
Ventricular Outflow Obstruction  (ISO)
Weight Loss  (EXP,ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-adrenaline  (ISO)
(R)-lipoic acid  (ISO)
(R)-pantothenic acid  (ISO)
(S)-nicotine  (ISO)
1-Oleoyl-2-acetyl-sn-glycerol  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-hydroxyprogesterone  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,2'-Dihydroxy-4-methoxybenzophenone  (ISO)
2,2,2-tetramine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2,6-dinitrotoluene  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-arachidonoylglycerol  (ISO)
2-deoxy-D-glucose  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,3',5-triiodo-L-thyronine  (EXP,ISO)
3,7-dihydropurine-6-thione  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-aminobenzamide  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP,ISO)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-phenylbutyric acid  (ISO)
5-aza-2'-deoxycytidine  (EXP)
5-fluorouracil  (EXP)
5-iodotubercidin  (ISO)
5-methyl-4-oxido-2-pyrazin-4-iumcarboxylic acid  (ISO)
5-oxo-L-proline  (EXP)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
6-Hydroxychlorzoxazone  (ISO)
9-cis-retinoic acid  (EXP,ISO)
acetaminophen O-beta-D-glucosiduronic acid  (ISO)
acetic acid  (EXP)
acrolein  (EXP)
actinomycin D  (EXP)
albuterol  (ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (EXP)
allethrin  (EXP)
amino acid  (EXP)
amiodarone  (EXP)
amlodipine  (ISO)
ammonium chloride  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
arachidonic acid  (ISO)
arotinoid acid  (ISO)
arsane  (EXP)
arsenic atom  (EXP)
arsenite(3-)  (EXP,ISO)
arsenous acid  (EXP,ISO)
aspartame  (EXP,ISO)
atenolol  (ISO)
atorvastatin calcium  (ISO)
atrazine  (ISO)
avobenzone  (ISO)
bafilomycin A1  (ISO)
baicalein  (ISO)
Bardoxolone methyl  (ISO)
benzene  (EXP)
benzo[a]pyrene  (EXP,ISO)
beta-D-glucosamine  (ISO)
bexarotene  (EXP,ISO)
bezafibrate  (ISO)
biotin  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bismuth atom  (ISO)
bismuthane  (ISO)
bisoprolol  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
boric acid  (EXP)
bromochloroacetic acid  (EXP)
bromocriptine  (ISO)
butan-1-amine  (EXP)
Butylbenzyl phthalate  (EXP,ISO)
Butylparaben  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcidiol  (ISO)
cannabidiolic acid  (EXP)
cannabigerol  (EXP)
cannabigerolic acid  (EXP)
capsaicin  (ISO)
capsazepine  (ISO)
carbamic acid  (EXP)
carvedilol  (ISO)
chlorpropamide  (ISO)
chlorpyrifos  (ISO)
chlorzoxazone  (ISO)
cholesterol  (EXP)
chromium atom  (ISO)
chromium(3+) trichloride  (ISO)
ciprofibrate  (ISO)
clofibrate  (ISO)
clonidine  (ISO)
clonidine (amino form)  (ISO)
clonidine (imino form)  (ISO)
clozapine  (ISO)
co-trimoxazole  (ISO)
cobalt dichloride  (ISO)
cocaine  (ISO)
conjugated linoleic acid  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
corticosterone  (ISO)
corticotropin  (ISO)
cortisol  (ISO)
curcumin  (EXP,ISO)
cycloheximide  (ISO)
cyproterone acetate  (ISO)
D-glucose  (EXP,ISO)
D-mannopyranose  (ISO)
decabromodiphenyl ether  (EXP)
demethoxycurcumin  (ISO)
desmosterol  (EXP)
dexamethasone  (EXP,ISO)
dexamethasone phosphate  (ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (ISO)
dibenziodolium  (ISO)
dicamba  (ISO)
Didymin  (ISO)
diethyl maleate  (ISO)
diethyl sulfate  (ISO)
diethylstilbestrol  (EXP)
digoxin  (ISO)
dimercaprol  (ISO)
diphosphoric acid  (EXP)
disodium selenite  (EXP,ISO)
dopamine  (ISO)
elemental selenium  (ISO)
enalaprilat dihydrate  (ISO)
equilin  (ISO)
ethanol  (EXP)
ethyl dihydrogen phosphate  (EXP)
ethylamine  (EXP)
farnesol  (ISO)
fenofibrate  (ISO)
fentin hydroxide  (EXP)
ferric ammonium citrate  (ISO)
fipronil  (ISO)
flavonoids  (ISO)
folic acid  (EXP,ISO)
fructose  (ISO)
fulvestrant  (EXP,ISO)
furan  (ISO)
gatifloxacin  (ISO)
gemcitabine  (ISO)
genistein  (EXP)
glimepiride  (ISO)
glucose  (EXP,ISO)
glutathione  (ISO)
glyburide  (ISO)
glycerol 2-phosphate  (EXP,ISO)
glycine  (EXP)
glycogen  (ISO)
glyoxylic acid  (EXP)
glyphosate  (ISO)
GW 7647  (EXP,ISO)
harmine  (ISO)
hemin  (ISO)
heptadecanoic acid  (EXP)
hexadecanoic acid  (EXP,ISO)
hispidulin  (EXP)
hydrogen peroxide  (ISO)
indometacin  (EXP,ISO)
inositol  (EXP)
isoflavones  (ISO)
isoprenaline  (ISO)
isopropyl palmitate  (EXP)
kynurenic acid  (ISO)
L-ascorbic acid  (EXP,ISO)
L-cystathionine  (EXP)
lanthanum atom  (ISO)
lercanidipine  (ISO)
levonorgestrel  (ISO)
Licarin A  (EXP)
lipoic acid  (ISO)
lipopolysaccharide  (ISO)
lithocholic acid  (ISO)
lovastatin  (ISO)
LY294002  (EXP,ISO)
magnesium atom  (ISO)
magnesium oxide  (ISO)
Magnolol  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
Melengestrol acetate  (ISO)
mercaptopurine  (ISO)
metformin  (ISO)
methadone  (ISO)
methotrexate  (ISO)
methyl dihydrogen phosphate  (EXP)
methylarsonite  (EXP)
methylglyoxal  (ISO)
metoclopramide  (ISO)
microcystin-LR  (ISO)
mifepristone  (ISO)
miquelianin  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
monosodium L-glutamate  (EXP)
Moxonidine  (ISO)
N,N-diethyl-m-toluamide  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-ethyl-N-nitrosourea  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-methylnicotinate  (EXP)
nateglinide  (ISO)
neomycin  (ISO)
nicotinamide  (ISO)
nicotine  (ISO)
nitric oxide  (ISO)
norethisterone  (ISO)
norgestrel  (ISO)
NS-398  (ISO)
ochratoxin A  (ISO)
octadecanoic acid  (EXP,ISO)
octocrylene  (ISO)
octreotide  (ISO)
olanzapine  (ISO)
oleanolic acid  (ISO)
oleic acid  (EXP,ISO)
oltipraz  (EXP)
orlistat  (ISO)
orotic acid  (ISO)
oxybenzone  (ISO)
palmitoleic acid  (EXP)
paracetamol  (ISO)
paroxetine  (ISO)
Pentagastrin  (ISO)
pentolinium tartrate  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
permethrin  (ISO)
phenobarbital  (ISO)
phenylarsine oxide  (ISO)
phenylarsonous acid  (ISO)
phloretin  (ISO)
phosphoric acid  (EXP)
pioglitazone  (EXP,ISO)
potassium chloride  (ISO)
prallethrin  (EXP)
prednisone  (ISO)
progesterone  (ISO)
propranolol  (ISO)
Ptaquiloside  (EXP)
purine-6-thiol  (ISO)
pyridine  (ISO)
pyruvic acid  (ISO)
quercetin  (ISO)
quinoxyfen  (EXP,ISO)
rac-lactic acid  (ISO)
resveratrol  (EXP,ISO)
rifampicin  (EXP,ISO)
rimonabant  (EXP)
risperidone  (ISO)
ritodrine  (ISO)
Ro 41-5253  (EXP,ISO)
Rutamarin  (EXP)
ruthenium red  (ISO)
saquinavir  (ISO)
saroglitazar  (ISO)
SB 203580  (ISO)
sebacic acid  (EXP)
selenium atom  (ISO)
sertraline  (ISO)
sirolimus  (ISO)
SKF-96365 hydrochloride  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP)
Sodium oleate  (ISO)
Sodium salicylate  (ISO)
spironolactone  (ISO)
staurosporine  (ISO)
streptozocin  (EXP,ISO)
sucrose  (ISO)
sulforaphane  (ISO)
sulpiride  (ISO)
tacrolimus hydrate  (ISO)
tauroursodeoxycholic acid  (ISO)
telmisartan  (ISO)
terbutaline  (ISO)
testosterone  (ISO)
thapsigargin  (ISO)
Thiocarbohydrazide  (ISO)
thyroxine  (ISO)
tolbutamide  (ISO)
tolylfluanid  (ISO)
triamcinolone  (ISO)
tributylstannane  (EXP,ISO)
triciribine  (ISO)
triclosan  (ISO)
triflumizole  (ISO)
trimethyltin  (ISO)
triphenyl phosphate  (EXP,ISO)
troglitazone  (ISO)
undecane  (EXP)
valproic acid  (ISO)
vandetanib  (ISO)
vanillic acid  (ISO)
vitamin D  (ISO)
wortmannin  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of protein kinase B activity  (ISO)
acute-phase response  (ISO)
alpha-beta T cell activation  (ISO)
carbohydrate metabolic process  (IEA)
ER overload response  (IMP)
fatty acid homeostasis  (ISO)
G protein-coupled receptor signaling pathway  (ISO)
glucose homeostasis  (IBA,IMP,ISO)
glucose metabolic process  (IMP)
glucose transmembrane transport  (TAS)
glycoprotein biosynthetic process  (ISO)
insulin processing  (IGI,ISO)
insulin receptor signaling pathway  (IDA,IMP,ISO)
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  (IMP)
lactate biosynthetic process  (ISO)
lipid biosynthetic process  (ISO)
lipid catabolic process  (IDA)
lipoprotein biosynthetic process  (ISO)
myoblast fusion  (IGI)
myotube differentiation  (IGI)
negative regulation of acute inflammatory response  (ISO)
negative regulation of fatty acid metabolic process  (ISO)
negative regulation of feeding behavior  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of gluconeogenesis  (ISO)
negative regulation of glycogen catabolic process  (ISO)
negative regulation of lipid catabolic process  (ISO)
negative regulation of NAD(P)H oxidase activity  (ISO)
negative regulation of protein catabolic process  (ISO)
negative regulation of protein secretion  (ISO)
negative regulation of proteolysis  (ISO)
negative regulation of reactive oxygen species biosynthetic process  (ISO)
negative regulation of respiratory burst involved in inflammatory response  (ISO)
negative regulation of transcription by RNA polymerase II  (IDA)
neuron projection maintenance  (ISO)
nitric oxide-cGMP-mediated signaling pathway  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of cytokine production  (ISO)
positive regulation of dendritic spine maintenance  (ISO)
positive regulation of DNA replication  (ISO)
positive regulation of ERK1 and ERK2 cascade  (IDA)
positive regulation of fatty acid biosynthetic process  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of glucose import  (ISO)
positive regulation of glucose metabolic process  (ISO)
positive regulation of glycogen biosynthetic process  (ISO)
positive regulation of glycolytic process  (ISO)
positive regulation of insulin receptor signaling pathway  (ISO)
positive regulation of lipoprotein lipase activity  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of mitotic nuclear division  (ISO)
positive regulation of NF-kappaB transcription factor activity  (ISO)
positive regulation of nitric oxide mediated signal transduction  (ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (IDA,ISO)
positive regulation of phosphatidylinositol 3-kinase activity  (IDA)
positive regulation of phosphatidylinositol 3-kinase signaling  (ISO)
positive regulation of protein autophosphorylation  (ISO)
positive regulation of protein kinase B signaling  (ISO)
positive regulation of protein localization to nucleus  (ISO)
positive regulation of protein metabolic process  (ISO)
positive regulation of protein secretion  (IBA)
positive regulation of respiratory burst  (ISO)
protein hexamerization  (ISO)
receptor internalization  (IDA)
regulation of cellular amino acid metabolic process  (ISO)
regulation of gene expression  (IDA)
regulation of phosphorylation  (IDA)
regulation of protein binding  (IDA)
regulation of protein localization  (ISO)
regulation of protein localization to plasma membrane  (ISO)
regulation of protein secretion  (ISO)
regulation of transmembrane transporter activity  (ISO)
vasodilation  (ISO)
wound healing  (ISO)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal astrocyte morphology  (IAGP)
abnormal cardiac muscle contractility  (IAGP)
abnormal circulating glucose level  (IAGP)
abnormal circulating insulin level  (IAGP)
abnormal glomerular capillary morphology  (IAGP)
abnormal glomerular mesangium morphology  (IAGP)
abnormal glucose homeostasis  (IAGP)
abnormal heart left ventricle morphology  (IAGP)
abnormal heart morphology  (IAGP)
abnormal homeostasis  (IAGP)
abnormal immune system physiology  (IAGP)
abnormal interferon-gamma secretion  (IAGP)
abnormal intestinal epithelium morphology  (IAGP)
abnormal kidney interstitium morphology  (IAGP)
abnormal Leydig cell morphology  (IAGP)
abnormal microglial cell morphology  (IAGP)
abnormal mitochondrial chromosome morphology  (IAGP)
abnormal mitochondrial morphology  (IAGP)
abnormal pancreas physiology  (IAGP)
abnormal pancreatic alpha cell morphology  (IAGP)
abnormal pancreatic beta cell mass  (IAGP)
abnormal pancreatic beta cell morphology  (IAGP)
abnormal pancreatic beta cell physiology  (IAGP)
abnormal pancreatic islet cell apoptosis  (IAGP)
abnormal pancreatic islet morphology  (IAGP)
abnormal response to transplant  (IAGP)
abnormal retina ganglion layer morphology  (IAGP)
abnormal retina neuronal layer morphology  (IAGP)
abnormal retina vasculature morphology  (IAGP)
abnormal seminiferous tubule morphology  (IAGP)
abnormal spermatic cord morphology  (IAGP)
abnormal spermatogonia morphology  (IAGP)
abnormal T cell physiology  (IAGP)
absent mature B cells  (IAGP)
absent pancreatic beta cells  (IAGP)
absent T cells  (IAGP)
acidosis  (IAGP)
akinesia  (IAGP)
albuminuria  (IAGP)
alopecia  (IAGP)
autoimmune response  (IAGP)
decreased adipocyte glucose uptake  (IAGP)
decreased anti-insulin autoantibody level  (IAGP)
decreased birth weight  (IAGP)
decreased body fat mass  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased bone mineral density  (IAGP)
decreased circulating insulin level  (IAGP)
decreased circulating leptin level  (IAGP)
decreased circulating triglyceride level  (IAGP)
decreased fetal weight  (IAGP)
decreased insulin secretion  (IAGP)
decreased liver triglyceride level  (IAGP)
decreased locomotor activity  (IAGP)
decreased muscle cell glucose uptake  (IAGP)
decreased pancreatic alpha cell number  (IAGP)
decreased pancreatic beta cell mass  (IAGP)
decreased pancreatic beta cell number  (IAGP)
decreased pancreatic beta cell proliferation  (IAGP)
decreased pancreatic islet cell apoptosis  (IAGP)
decreased respiratory quotient  (IAGP)
decreased skeletal muscle triglyceride level  (IAGP)
decreased subcutaneous adipose tissue amount  (IAGP)
decreased susceptibility to autoimmune diabetes  (IAGP)
degranulated pancreatic beta cells  (IAGP)
dehydration  (IAGP)
disorganized pancreatic islets  (IAGP)
embryonic growth retardation  (IAGP)
enlarged liver  (IAGP)
enlarged pancreatic islets  (IAGP)
expanded mesangial matrix  (IAGP)
glomerulosclerosis  (IAGP)
heart left ventricle hypertrophy  (IAGP)
hematoma  (IAGP)
hepatic steatosis  (IAGP)
hydronephrosis  (IAGP)
hyperglycemia  (IAGP)
impaired glucose tolerance  (IAGP)
increased adipocyte glucose uptake  (IAGP)
increased anti-insulin autoantibody level  (IAGP)
increased anxiety-related response  (IAGP)
increased body weight  (IAGP)
increased carbon dioxide production  (IAGP)
increased circulating cholesterol level  (IAGP)
increased circulating glucose level  (IAGP)
increased circulating HDL cholesterol level  (IAGP)
increased circulating insulin level  (IAGP)
increased circulating ketone body level  (IAGP)
increased circulating LDL cholesterol level  (IAGP)
increased circulating triglyceride level  (IAGP)
increased circulating VLDL cholesterol level  (IAGP)
increased energy expenditure  (IAGP)
increased erythrocyte cell number  (IAGP)
increased fluid intake  (IAGP)
increased food intake  (IAGP)
increased granulocyte number  (IAGP)
increased insulin secretion  (IAGP)
increased insulin sensitivity  (IAGP)
increased leukocyte cell number  (IAGP)
increased macrophage cell number  (IAGP)
increased monocyte cell number  (IAGP)
increased oxygen consumption  (IAGP)
increased pancreatic alpha cell mass  (IAGP)
increased pancreatic alpha cell number  (IAGP)
increased pancreatic alpha cell proliferation  (IAGP)
increased pancreatic beta cell apoptosis  (IAGP)
increased pancreatic beta cell mass  (IAGP)
increased pancreatic beta cell number  (IAGP)
increased pancreatic beta cell proliferation  (IAGP)
increased pancreatic islet cell apoptosis  (IAGP)
increased renal glomerular filtration rate  (IAGP)
increased renal glomerulus basement membrane thickness  (IAGP)
increased retina apoptosis  (IAGP)
increased susceptibility to atherosclerosis  (IAGP)
increased susceptibility to autoimmune diabetes  (IAGP)
increased urine glucose level  (IAGP)
increased vascular permeability  (IAGP)
insulin resistance  (IAGP)
insulitis  (IAGP)
kyphosis  (IAGP)
mesangiolysis  (IAGP)
no abnormal phenotype detected  (IAGP)
pancreas inflammation  (IAGP)
polydipsia  (IAGP)
polyphagia  (IAGP)
polyuria  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
premature death  (IAGP)
renal glomerular protein deposits  (IAGP)
salivary gland inflammation  (IAGP)
small pancreatic islets  (IAGP)
thick interventricular septum  (IAGP)

References - curated
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40. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
41. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
42. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
43. Mouse MP Annotation Import Pipeline RGD automated import pipeline
44. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
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Additional References at PubMed
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PMID:23884891   PMID:23894189   PMID:23903190   PMID:23929935   PMID:23940571   PMID:23946427   PMID:23951058   PMID:23973805   PMID:23977133   PMID:23977269   PMID:23996959   PMID:24003152  
PMID:24009262   PMID:24064341   PMID:24114270   PMID:24127484   PMID:24129189   PMID:24135141   PMID:24163078   PMID:24163148   PMID:24166718   PMID:24226524   PMID:24236044   PMID:24247978  
PMID:24248465   PMID:24258027   PMID:24324549   PMID:24370601   PMID:24385342   PMID:24387268   PMID:24395790   PMID:24449844   PMID:24452639   PMID:24458356   PMID:24463424   PMID:24477974  
PMID:24487024   PMID:24491571   PMID:24574008   PMID:24583012   PMID:24677271   PMID:24703908   PMID:24721715   PMID:24726366   PMID:24740573   PMID:24743240   PMID:24812425   PMID:24820416  
PMID:24840347   PMID:24848070   PMID:24848689   PMID:24943217   PMID:24966386   PMID:25053427   PMID:25063451   PMID:25107471   PMID:25126760   PMID:25133424   PMID:25143383   PMID:25176043  
PMID:25186293   PMID:25187372   PMID:25207540   PMID:25233132   PMID:25249008   PMID:25249504   PMID:25274988   PMID:25343275   PMID:25367577   PMID:25404734   PMID:25428125   PMID:25428948  
PMID:25500700   PMID:25523391   PMID:25536533   PMID:25576928   PMID:25613939   PMID:25652387   PMID:25652452   PMID:25695968   PMID:25715394   PMID:25715395   PMID:25784544   PMID:25789863  
PMID:25801033   PMID:25902541   PMID:25912440   PMID:25912690   PMID:25918232   PMID:25944670   PMID:25957229   PMID:25985365   PMID:25987249   PMID:26015547   PMID:26021489   PMID:26029927  
PMID:26041444   PMID:26075820   PMID:26122048   PMID:26155745   PMID:26156633   PMID:26169832   PMID:26177052   PMID:26203118   PMID:26214584   PMID:26232095   PMID:26235979   PMID:26251404  
PMID:26334030   PMID:26340930   PMID:26361146   PMID:26378466   PMID:26389675   PMID:26395740   PMID:26411367   PMID:26450967   PMID:26470785   PMID:26494286   PMID:26494792   PMID:26518685  
PMID:26534984   PMID:26552047   PMID:26554594   PMID:26576643   PMID:26586006   PMID:26595448   PMID:26597883   PMID:26626461   PMID:26631740   PMID:26683376   PMID:26696124   PMID:26747235  
PMID:26752640   PMID:26771085   PMID:26784909   PMID:26822858   PMID:26830324   PMID:26858454   PMID:26887806   PMID:26901059   PMID:26944677   PMID:26953160   PMID:26956881   PMID:26968895  
PMID:27052164   PMID:27055260   PMID:27130279   PMID:27133129   PMID:27145011   PMID:27159053   PMID:27206247   PMID:27270601   PMID:27283743   PMID:27292642   PMID:27297878   PMID:27335233  
PMID:27340827   PMID:27349930   PMID:27382987   PMID:27475229   PMID:27482904   PMID:27495224   PMID:27528615   PMID:27572106   PMID:27581061   PMID:27585521   PMID:27620487   PMID:27656411  
PMID:27658750   PMID:27706190   PMID:27736991   PMID:27740873   PMID:27802520   PMID:27813676   PMID:27820699   PMID:27855634   PMID:27864307   PMID:27892540   PMID:27899487   PMID:27936229  
PMID:27993987   PMID:28017717   PMID:28069641   PMID:28071588   PMID:28071719   PMID:28100774   PMID:28102311   PMID:28118981   PMID:28119571   PMID:28154187   PMID:28193997   PMID:28214591  
PMID:28248965   PMID:28259677   PMID:28322199   PMID:28324005   PMID:28424212   PMID:28457793   PMID:28490532   PMID:28493939   PMID:28535269   PMID:28576773   PMID:28580283   PMID:28624504  
PMID:28630133   PMID:28700945   PMID:28705881   PMID:28793255   PMID:28837672   PMID:28883608   PMID:28893946   PMID:28922976   PMID:29029025   PMID:29058721   PMID:29061652   PMID:29074590  
PMID:29079704   PMID:29122848   PMID:29133483   PMID:29180572   PMID:29203863   PMID:29207116   PMID:29211719   PMID:29211853   PMID:29231167   PMID:29272356   PMID:29304075   PMID:29330353  
PMID:29348399   PMID:29348593   PMID:29371604   PMID:29373286   PMID:29420703   PMID:29434227   PMID:29434323   PMID:29439088   PMID:29507125   PMID:29512653   PMID:29590218   PMID:29632144  
PMID:29654303   PMID:29675273   PMID:29761600   PMID:29851956   PMID:29875100   PMID:29891593   PMID:29910119   PMID:29913163   PMID:29972779   PMID:29975570   PMID:29995913   PMID:30019207  
PMID:30022165   PMID:30065034   PMID:30065074   PMID:30135482   PMID:30168649   PMID:30207172   PMID:30250024   PMID:30293775   PMID:30305368   PMID:30347392   PMID:30361701   PMID:30412050  
PMID:30420428   PMID:30425063   PMID:30425286   PMID:30463601   PMID:30480744   PMID:30487608   PMID:30488085   PMID:30498224   PMID:30504829   PMID:30532991   PMID:30576241   PMID:30590051  
PMID:30620636   PMID:30620902   PMID:30665571   PMID:30733468   PMID:30773020   PMID:30785802   PMID:30796028   PMID:30853440   PMID:30862678   PMID:30886059   PMID:30899071   PMID:30914477  
PMID:30978208   PMID:31039005   PMID:31040360   PMID:31069235   PMID:31091127   PMID:31116975   PMID:31160417   PMID:31160421   PMID:31166707   PMID:31185088   PMID:31186351   PMID:31187215  
PMID:31201281   PMID:31208980   PMID:31217360   PMID:31250581   PMID:31311313   PMID:31323030   PMID:31345937   PMID:31380462   PMID:31412250   PMID:31492508   PMID:31506549   PMID:31509011  
PMID:31509750   PMID:31519700   PMID:31604927   PMID:31610731   PMID:31624141   PMID:31682591   PMID:31726870   PMID:31806622   PMID:31806625   PMID:31836691   PMID:31875961   PMID:31882119  
PMID:31914588   PMID:31923647   PMID:31970899   PMID:31974143   PMID:32005704   PMID:32059775   PMID:32060653   PMID:32072744   PMID:32165492   PMID:32169892   PMID:32183843   PMID:32198206  
PMID:32241676   PMID:32245798   PMID:32275905   PMID:32313051   PMID:32321760   PMID:32332156   PMID:32332159   PMID:32350257   PMID:32375022   PMID:32404350   PMID:32439763   PMID:32467243  
PMID:32546815   PMID:32590005   PMID:32640216   PMID:32644973   PMID:32699230   PMID:32708537   PMID:32715748   PMID:32726619   PMID:32817622   PMID:32857951   PMID:32913274   PMID:32994272  
PMID:33028844   PMID:33057429   PMID:33060607   PMID:33069809   PMID:33090974   PMID:33485967   PMID:33505018   PMID:33527355   PMID:33567267   PMID:33606210   PMID:33653874   PMID:33658226  
PMID:33662611   PMID:33667344   PMID:33667544   PMID:33713581   PMID:33810480   PMID:33811703   PMID:33831261   PMID:33852861   PMID:33859429   PMID:33872860   PMID:33932339   PMID:34071003  
PMID:34086738   PMID:34163008   PMID:34201511   PMID:34267243   PMID:34282152   PMID:34385258   PMID:34446743   PMID:34462258   PMID:34487921   PMID:34489701   PMID:34534285   PMID:34599818  
PMID:34645928   PMID:34673901   PMID:34675883   PMID:34680110   PMID:34831029   PMID:34845324   PMID:34882677   PMID:35108512   PMID:35113157   PMID:35129674   PMID:35138346   PMID:35529069  
PMID:35608871   PMID:35927244   PMID:35940125   PMID:35998583   PMID:36001973   PMID:36017799   PMID:36170671   PMID:36172176   PMID:36202974   PMID:36265286   PMID:36522378   PMID:36529318  


Comparative Map Data
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm397142,232,393 - 142,233,463 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7142,232,393 - 142,297,118 (-)EnsemblGRCm39 Ensembl
GRCm387142,678,656 - 142,679,726 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7142,678,656 - 142,743,381 (-)EnsemblGRCm38mm10GRCm38
MGSCv377149,864,561 - 149,865,613 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367142,488,051 - 142,489,098 (-)NCBIMGSCv36mm8
Celera7142,434,985 - 142,436,037 (-)NCBICelera
Cytogenetic Map7F5NCBI
cM Map788.0NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38112,159,779 - 2,161,209 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl112,159,779 - 2,161,221 (-)EnsemblGRCh38hg38GRCh38
GRCh37112,181,009 - 2,182,439 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36112,137,585 - 2,139,015 (-)NCBINCBI36Build 36hg18NCBI36
Build 34112,137,584 - 2,139,000NCBI
Celera112,217,516 - 2,218,946 (-)NCBICelera
Cytogenetic Map11p15.5NCBI
HuRef111,971,272 - 1,972,702 (-)NCBIHuRef
CHM1_1112,179,957 - 2,181,387 (-)NCBICHM1_1
T2T-CHM13v2.0112,247,427 - 2,248,857 (-)NCBIT2T-CHM13v2.0
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21197,843,277 - 197,992,522 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1197,843,281 - 197,864,775 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1206,216,147 - 206,217,214 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01213,302,063 - 213,303,130 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01205,976,222 - 205,977,289 (-)NCBIRnor_WKY
Rnor_6.01215,856,967 - 215,858,034 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1215,856,971 - 215,858,034 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01222,751,786 - 222,756,821 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41202,935,548 - 202,936,379 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11203,123,613 - 203,124,445 (-)NCBI
Celera1195,461,309 - 195,462,376 (-)NCBICelera
Cytogenetic Map1q41NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495542213,909,407 - 13,910,419 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542213,909,408 - 13,910,419 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.1112,230,309 - 2,231,666 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl112,218,117 - 2,231,666 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0112,200,785 - 2,202,579 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.11846,324,047 - 46,324,933 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1846,324,041 - 46,325,122 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1844,933,843 - 44,934,720 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01847,003,520 - 47,004,406 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1847,003,520 - 47,004,411 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11846,452,280 - 46,453,156 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01846,032,597 - 46,033,483 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01846,779,045 - 46,779,926 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_0244049471,748,017 - 1,749,237 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049368161,002,137 - 1,003,357 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049368161,002,137 - 1,003,357 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl21,496,842 - 1,497,841 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.121,496,842 - 1,498,052 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.111,965,128 - 1,969,090 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603899,163,059 - 99,164,540 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_00462476714,999,088 - 15,000,035 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476714,999,088 - 15,000,035 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1330
Count of miRNA genes:396
Interacting mature miRNAs:454
Transcripts:ENSMUST00000000220, ENSMUST00000105930, ENSMUST00000105931, ENSMUST00000105932, ENSMUST00000105933, ENSMUST00000105934, ENSMUST00000125933, ENSMUST00000162317
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12792978Fbmd3_mfemoral bone mineral density 3, females only (mouse)77050288142367832Mouse
27226751Femd5_mfemur midshaft diameter 5, 10 week (mouse)753249748143153737Mouse
27095933Ulnl3_mulna length 3, 5 week (mouse)773149748143153737Mouse
14700684Civq1_mcerebral infarct volume QTL 1 (mouse)7109707335143707335Mouse
14700687Civq5_mcerebral infarct volume QTL 5 (mouse)7109707335143707335Mouse
14700688Civq6_mcerebral infarct volume QTL 6 (mouse)7109707335143707335Mouse
11059562Lmr21b_mleishmaniasis resistance 21b (mouse)7110967235144967336Mouse
10402499Lmr21_mleishmaniasis resistance 21 (mouse)Not determined7110967235144967336Mouse
1302032Alcp12_malcohol preference locus 12 (mouse)Not determined7111166122144995196Mouse
1301898Alcp14_malcohol preference locus 14 (mouse)Not determined7111166122144995196Mouse
1300670Sluc19_msusceptibility to lung cancer 19 (mouse)Not determined7111166122144995196Mouse
4142444Femwf5_mfemur work to failure 5 (mouse)Not determined112552248144995196Mouse
1300747Skts2_mskin tumor susceptibility 2 (mouse)Not determined7112922733144995196Mouse
1300677Bmd9_mbone mineral density 9 (mouse)Not determined7116634089144995196Mouse
1357711Adbg1_madult body growth 1 (mouse)Not determined7118693381144398314Mouse
1301773Stheal7_msoft tissue heal 7 (mouse)Not determined7119132573144995196Mouse
1301590Pbwg3_mpostnatal body weight growth 3 (mouse)Not determined7127311241144995196Mouse
1300566Sluc8_msusceptibility to lung cancer 8 (mouse)Not determined7127398151144995196Mouse
14746988Manh63_mmandible shape 63 (mouse)7127735437144995196Mouse