Il4 (interleukin 4) - Rat Genome Database

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Gene: Il4 (interleukin 4) Mus musculus
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Symbol: Il4
Name: interleukin 4
RGD ID: 10796
MGI Page MGI
Description: Enables cytokine activity. Involved in several processes, including innate immune response in mucosa; interleukin-4-mediated signaling pathway; and positive regulation of metabolic process. Acts upstream of or within several processes, including T-helper cell differentiation; positive regulation of macromolecule metabolic process; and regulation of lymphocyte activation. Located in external side of plasma membrane and extracellular space. Is expressed in several structures, including brain; gut; hemolymphoid system gland; liver; and placenta. Used to study Sjogren's syndrome; atopic dermatitis; and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including asthma (multiple); atopic dermatitis; autoimmune disease (multiple); pancreatic cancer (multiple); and viral hepatitis (multiple). Orthologous to human IL4 (interleukin 4).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: B-cell growth factor 1; B-cell IgG differentiation factor; B-cell stimulatory factor 1; BSF-1; IGG1 induction factor; Il; Il-4; interleukin-4; lymphocyte stimulatory factor 1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391153,503,287 - 53,509,492 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1153,493,809 - 53,509,496 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381153,612,460 - 53,618,665 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1153,602,982 - 53,618,669 (-)Ensemblmm10GRCm38
MGSCv371153,425,962 - 53,432,167 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361153,455,891 - 53,462,088 (-)NCBIMGSCv36mm8
Celera1158,191,990 - 58,198,195 (-)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1131.97NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (ISO)
Acute Experimental Pancreatitis  (ISO)
Acute Hepatitis  (ISO)
Acute Lung Injury  (ISO)
acute myocardial infarction  (ISO)
adult T-cell leukemia/lymphoma  (ISO)
allergic contact dermatitis  (ISO)
allergic disease  (ISO)
allergic rhinitis  (ISO)
alopecia universalis  (ISO)
Alzheimer's disease  (ISO)
Anaphylaxis  (IEP,ISO)
anogenital venereal wart  (ISO)
anti-basement membrane glomerulonephritis  (ISO)
aspirin-induced respiratory disease  (ISO)
asthma  (IEP,IMP,ISO)
atopic dermatitis  (IAGP,ISO)
autistic disorder  (ISO)
autoimmune disease  (ISO)
autoimmune hepatitis  (IEP,ISO)
autoimmune thrombocytopenic purpura  (ISO)
autoimmune thyroiditis  (ISO)
Behcet's disease  (ISO)
biliary tract benign neoplasm  (ISO)
Bovine Tuberculosis  (ISO)
Brain Injuries  (ISO)
bronchiolitis obliterans  (ISO)
cardiomyopathy  (ISO)
carotid stenosis  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
cholestasis  (ISO)
Chromosome Breakage  (ISO)
Chronic Hepatitis B  (ISO)
Chronic Hepatitis C  (ISO)
cognitive disorder  (ISO)
colitis  (IDA,ISO)
common cold  (IEP)
contact dermatitis  (IEP)
COVID-19  (ISO)
cutaneous leishmaniasis  (ISO)
cystic echinococcosis  (ISO)
cystitis  (ISO)
dermatitis  (ISO)
dermatomyositis  (ISO)
drug allergy  (ISO)
Drug Eruptions  (ISO)
Edema  (ISO)
Experimental Arthritis  (ISO)
Experimental Autoimmune Encephalomyelitis  (IMP,ISO)
Experimental Autoimmune Uveoretinitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (IEP)
familial adenomatous polyposis 1  (ISO)
Fibrosis  (IMP,ISO)
Gaucher's disease  (IEP)
Granuloma  (ISO)
Graves' disease  (ISO)
Hand Osteoarthritis  (ISO)
Hemorrhagic Shock  (ISO)
hepatitis B  (ISO)
hepatitis C  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
herpes zoster  (ISO)
high grade glioma  (IMP)
Human Influenza  (IEP)
hypothyroidism  (ISO)
Immediate Hypersensitivity  (ISO)
irritant dermatitis  (ISO)
Kawasaki disease  (IEP)
Knee Osteoarthritis  (ISO)
leishmaniasis  (IMP,ISO)
Lung Reperfusion Injury  (ISO)
malignant mesothelioma  (ISO)
Meningococcal Infections  (ISO)
metabolic dysfunction-associated steatotic liver disease  (ISO)
middle cerebral artery infarction  (ISO)
multiple sclerosis  (ISO)
Nematode Infections  (ISO)
nephritis  (ISO)
nephrotic syndrome  (ISO)
Neurodevelopmental Disorders  (ISO)
Otitis Media with Effusion  (ISO)
pancreatic cancer  (IDA,ISO)
pancreatic ductal carcinoma  (ISO)
pelvic inflammatory disease  (ISO)
Perennial Allergic Rhinitis  (ISO)
pleural disease  (ISO)
pneumoconiosis  (ISO)
pneumonia  (ISO)
polymyositis  (ISO)
Premature Birth  (ISO)
primary biliary cholangitis  (ISO)
primary cutaneous T-cell non-Hodgkin lymphoma  (ISO)
psoriasis  (IDA,ISO)
pulmonary fibrosis  (IEP,ISO)
pulmonary hypertension  (IMP)
pulmonary tuberculosis  (IEP)
respiratory allergy  (IMP,ISO)
Respiratory Sounds  (ISO)
Respiratory Tract Infections  (ISO)
rhinitis  (IEP,ISO)
Rhinosinusitis  (ISO)
Seasonal Allergic Rhinitis  (ISO)
Sepsis  (ISO)
Sjogren's syndrome  (IAGP)
Spinal Cord Injuries  (ISO)
Staphylococcal Infections  (ISO)
Stroke  (ISO)
systemic lupus erythematosus  (ISO)
systemic scleroderma  (ISO)
temporal arteritis  (ISO)
toxocariasis  (ISO)
trypanosomiasis  (ISO)
type 1 diabetes mellitus  (IAGP)
vitiligo  (ISO)
Weight Loss  (ISO)
Xerostomia  (IMP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-trans-(S)-allethrin  (ISO)
(-)-matairesinol  (EXP)
(20S)-ginsenoside Rh1  (EXP)
(4-oxo-3-\{[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl\}-3,4-dihydrophthalazin-1-yl)acetic acid  (EXP)
(R)-lipoic acid  (ISO)
1,2-dibutyrin  (EXP)
1,2-dichloroethane  (ISO)
1,3,5-trinitrobenzene  (EXP)
1,4-phenylenediamine  (EXP)
1-chloro-2,4,6-trinitrobenzene  (EXP,ISO)
1-chloro-2,4-dinitrobenzene  (EXP)
1-fluoro-2,4-dinitrobenzene  (EXP)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP)
13,14-dihydro-15-ketoprostaglandin D2  (EXP)
15-acetyldeoxynivalenol  (EXP)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9-hexadecafluorononanoic acid  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP,ISO)
2,4-D  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2,6-di-tert-butyl-4-methylphenol  (EXP)
2-amino-2-deoxy-D-glucopyranose  (EXP,ISO)
2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-1,2,4-triazol-3-one  (ISO)
2-tert-butylhydroquinone  (EXP,ISO)
3',5'-cyclic AMP  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3-acetyldeoxynivalenol  (EXP)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4'-hydroxydiclofenac  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (EXP)
4-ethylphenol  (EXP)
4-nitro-m-cresol  (EXP)
4-nonylphenol  (ISO)
4-tolyl isocyanate  (EXP)
5-azacytidine  (ISO)
6-anilino-5,8-quinolinedione  (EXP)
6-Methoxyflavone  (EXP)
6alpha-methylprednisolone  (EXP,ISO)
8-Br-cAMP  (ISO)
8-bromo-3',5'-cyclic GMP  (EXP)
9-cis-retinoic acid  (EXP,ISO)
abacavir  (ISO)
acetaldehyde  (ISO)
acetone  (ISO)
acetylsalicylic acid  (ISO)
acrylic acid  (ISO)
albuterol  (ISO)
alclometasone dipropionate  (ISO)
aldehydo-D-glucosamine  (EXP,ISO)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (EXP)
allicin  (ISO)
alpha-galactosylceramide  (EXP)
alpha-hexylcinnamaldehyde  (EXP,ISO)
alpha-linolenic acid  (ISO)
aluminium atom  (EXP)
aluminium hydroxide  (EXP,ISO)
aluminium sulfate (anhydrous)  (EXP)
aluminium(0)  (EXP)
amiodarone  (ISO)
ammonium chloride  (ISO)
amorolfine  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antigen  (EXP)
apigenin  (EXP,ISO)
arachidonic acid  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenous acid  (EXP,ISO)
asbestos  (EXP,ISO)
asperentin  (EXP)
atrazine  (ISO)
azathioprine  (ISO)
Azoxymethane  (ISO)
BAPTA  (ISO)
bazedoxifene  (ISO)
beclomethasone  (EXP,ISO)
benzalkonium chloride  (EXP)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzofurans  (EXP)
berberine  (EXP)
beta-D-glucosamine  (EXP,ISO)
beta-endorphin  (ISO)
betamethasone valerate  (ISO)
bexarotene  (ISO)
bifenthrin  (EXP)
biochanin A  (EXP)
bis(2-chloroethyl) sulfide  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
bleomycin A2  (EXP,ISO)
boric acid  (EXP,ISO)
boron atom  (ISO)
Brevetoxin B  (ISO)
bucladesine  (ISO)
budesonide  (EXP,ISO)
buprenorphine  (ISO)
butane-2,3-dione  (EXP)
butenafine  (ISO)
Butylbenzyl phthalate  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (ISO)
Calcimycin  (ISO)
calciol  (ISO)
calcipotriol  (EXP)
calcitriol  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
cannabidiol  (EXP)
capsaicin  (EXP,ISO)
capsazepine  (EXP)
carbachol  (EXP)
carbamazepine  (ISO)
carbon monoxide  (EXP,ISO)
carbon nanotube  (EXP,ISO)
carveol  (EXP)
caryophyllene oxide  (EXP)
ceric oxide  (EXP)
cerium trichloride  (EXP)
cetirizine  (EXP)
chlorambucil  (ISO)
chloroform  (EXP)
chloroquine  (EXP)
chlorphenamine  (ISO)
chlorpyrifos  (ISO)
choline  (EXP)
chromium atom  (ISO)
chromium(6+)  (ISO)
chrysin  (EXP,ISO)
cilostazol  (EXP)
ciprofloxacin  (ISO)
cis-caffeic acid  (EXP)
cisplatin  (ISO)
cladribine  (ISO)
clarithromycin  (ISO)
clopidogrel  (EXP)
cobalt atom  (ISO)
cobalt dichloride  (EXP)
cocaine  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cordycepin  (EXP,ISO)
corn oil  (EXP,ISO)
cortisol  (EXP)
crocidolite asbestos  (EXP)
cupressuflavone  (EXP)
curcumin  (EXP,ISO)
cycloastragenol  (ISO)
cyclopentanes  (ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (EXP,ISO)
cyfluthrin  (ISO)
cyhalothrin  (ISO)
D-penicillamine  (ISO)
daidzein  (EXP)
DDE  (EXP,ISO)
DDT  (ISO)
decabromodiphenyl ether  (EXP)
deguelin  (ISO)
deoxynivalenol  (EXP,ISO)
desferrioxamine B  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP,ISO)
Di-n-octyl phthalate  (EXP)
Diallyl sulfide  (EXP)
diarsenic trioxide  (EXP,ISO)
diazinon  (EXP,ISO)
dibenzothiazol-2-yl disulfide  (EXP)
dibutyl phthalate  (EXP,ISO)
diclofenac  (ISO)
dicloxacillin  (EXP)
dicyclohexylmethane-4,4'-diisocyanate  (EXP)
Didecyldimethylammonium  (EXP)
diethyl maleate  (ISO)
diethyl phthalate  (EXP)
diethylamine  (EXP)
diflorasone  (EXP)
Diisodecyl phthalate  (EXP)
diisononyl phthalate  (EXP)
diisopropyl fluorophosphate  (EXP)
Dimaprit  (EXP)
Dimethyl phthalate  (ISO)
dioscin  (EXP)
dioxygen  (ISO)
diphenylmethane-4,4'-diisocyanate  (EXP)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
diuron  (ISO)
donepezil hydrochloride  (EXP)
doxorubicin  (EXP,ISO)
dydrogesterone  (EXP,ISO)
edaravone  (ISO)
elemental boron  (ISO)
elemental selenium  (EXP,ISO)
emamectin benzoate  (ISO)
emodin  (EXP)
epinastine  (ISO)
equol  (EXP)
Erionite  (EXP)
estriol  (EXP)
ethanol  (EXP,ISO)
etoposide  (ISO)
famotidine  (EXP)
fentanyl  (ISO)
ferric oxide  (EXP)
ferrostatin-1  (ISO)
fingolimod hydrochloride  (EXP)
fisetin  (ISO)
flavonoids  (ISO)
fluoranthene  (ISO)
fluorescein 5-isothiocyanate  (EXP)
flutamide  (EXP)
fluticasone  (ISO)
folic acid  (EXP)
fomepizole  (ISO)
formaldehyde  (EXP,ISO)
formononetin  (EXP)
formoterol fumarate  (ISO)
fragrance  (ISO)
fulvestrant  (EXP)
furfuryl alcohol  (EXP)
gadodiamide hydrate  (ISO)
gadolinium trichloride  (ISO)
Ganoderic acid C2  (EXP)
Gastrodin  (EXP)
gemcitabine  (ISO)
genistein  (EXP,ISO)
ginsenoside C-K  (EXP)
glutathione  (EXP,ISO)
Glutathione ethyl ester  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
gossypin  (ISO)
graphite  (EXP)
GSK2193874  (EXP)
harmaline  (EXP)
helenalin  (ISO)
heroin  (ISO)
hesperidin  (EXP)
hexachlorobenzene  (ISO)
hexamethylene diisocyanate  (EXP)
hispidulin  (ISO)
histamine  (EXP)
Honokiol  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (EXP)
hydroxysafflor yellow A  (EXP)
hydroxyzine  (EXP)
ibuprofen  (EXP)
IC-87114  (EXP)
idelalisib  (EXP)
imidacloprid  (ISO)
imiquimod  (ISO)
immunological adjuvant  (ISO)
Indeno[1,2,3-cd]pyrene  (EXP)
indirubin  (ISO)
indometacin  (ISO)
ionomycin  (EXP,ISO)
iron(2+) sulfate (anhydrous)  (ISO)
isophorone diisocyanate  (EXP)
isoprenaline  (ISO)
isosilybin A  (EXP)
isotretinoin  (ISO)
itraconazole  (ISO)
kaempferol  (ISO)
ketoconazole  (ISO)
ketorolac  (ISO)
L-arginine  (ISO)
L-ascorbic acid  (EXP)
lactacystin  (EXP)
lead diacetate  (EXP,ISO)
lead(0)  (EXP)
lead(II) chloride  (EXP)
leflunomide  (EXP,ISO)
leukotriene B4  (ISO)
levamisole  (EXP,ISO)
lidocaine  (EXP)
linoleic acid  (ISO)
lipoic acid  (ISO)
lipopolysaccharide  (EXP,ISO)
lipoteichoic acid  (ISO)
lipoxin A4  (EXP)
lithium atom  (ISO)
lithium hydride  (ISO)
loperamide  (ISO)
losartan  (ISO)
Luliconazole  (ISO)
luteolin  (EXP,ISO)
Luteolin 7-methyl ether  (EXP)
LY294002  (EXP,ISO)
malathion  (EXP)
manganese atom  (EXP)
manganese(0)  (EXP)
manganese(II) chloride  (EXP)
melatonin  (EXP)
mercury atom  (EXP)
mercury dichloride  (EXP,ISO)
mercury(0)  (EXP)
mesalamine  (ISO)
methadone  (ISO)
methanol  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
methoxychlor  (EXP)
methyl isocyanate  (ISO)
methyl salicylate  (EXP)
miconazole  (ISO)
microcystin-LR  (ISO)
mifepristone  (EXP,ISO)
mitogen  (EXP)
MK 571  (EXP)
Monobutylphthalate  (ISO)
monodansylcadaverine  (EXP)
montelukast  (EXP)
morphine  (EXP,ISO)
Morroniside  (EXP)
moxifloxacin  (ISO)
mycophenolic acid  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N,N-diethyl-m-toluamide  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-beta-D-glucosamine  (EXP)
N-acetyl-D-glucosamine  (EXP)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-methyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (ISO)
naphthalene  (ISO)
naproxen  (ISO)
naringin  (EXP)
neocuproine  (EXP)
nicardipine  (EXP)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
nitrendipine  (EXP)
nitric oxide  (EXP,ISO)
nitrites  (EXP)
nitrogen dioxide  (EXP)
nitroprusside  (EXP,ISO)
Nivalenol  (EXP)
nonanoic acid  (EXP)
Nonylphenol  (EXP)
NS-398  (EXP)
obeticholic acid  (EXP)
ochratoxin A  (ISO)
okadaic acid  (EXP)
Olopatadine hydrochloride  (EXP,ISO)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
parathion  (EXP)
patulin  (ISO)
PCB138  (ISO)
pentachlorophenol  (EXP)
pentamidine  (EXP)
Pentoxifylline  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
permethrin  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phosgene  (ISO)
phthalaldehyde  (EXP)
phthalic anhydride  (EXP,ISO)
pioglitazone  (EXP)
piperonyl butoxide  (EXP,ISO)
pirinixic acid  (EXP,ISO)
poly(I:C)  (EXP,ISO)
polyphosphates  (ISO)
prednisolone  (EXP,ISO)
prednisone  (ISO)
progesterone  (EXP,ISO)
prostaglandin D2  (ISO)
prostaglandin E2  (EXP,ISO)
prostaglandin F2alpha  (ISO)
pyrene  (EXP,ISO)
Pyridostigmine bromide  (ISO)
pyruvic acid  (ISO)
quercetin  (EXP,ISO)
raloxifene  (ISO)
ranitidine  (ISO)
reactive oxygen species  (ISO)
resveratrol  (EXP,ISO)
retinyl acetate  (EXP)
ribavirin  (ISO)
ricinoleic acid  (ISO)
Ro 41-5253  (ISO)
rolipram  (EXP)
rotenone  (EXP)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
salicylic acid  (ISO)
Sanggenon C  (ISO)
SB 203580  (ISO)
SB 290157  (EXP)
selenium atom  (EXP,ISO)
selenomethionine  (EXP)
serotonin  (EXP)
serpentine asbestos  (EXP)
sildenafil citrate  (EXP)
silicon dioxide  (EXP)
Silidianin  (EXP)
silver(1+) nitrate  (EXP)
simvastatin  (EXP,ISO)
sirolimus  (EXP)
sodium arsenite  (EXP,ISO)
sodium aurothiomalate  (EXP)
sodium benzoate  (ISO)
sodium dichromate  (ISO)
sodium dodecyl sulfate  (EXP)
sodium fluoride  (ISO)
sodium hexachloroplatinate  (EXP)
Sodium salicylate  (ISO)
sodium stibogluconate  (EXP,ISO)
solasodine  (ISO)
spathulenol  (EXP)
SR 144528  (ISO)
staurosporine  (ISO)
streptozocin  (ISO)
styrene  (EXP)
Sucralfate  (ISO)
sulfasalazine  (ISO)
sulforaphane  (EXP)
sulfur dioxide  (EXP)
sumatriptan  (ISO)
sunitinib  (EXP)
Sunset Yellow FCF  (EXP)
synephrine  (EXP,ISO)
syringin  (EXP)
T-2 toxin  (EXP)
tacrolimus hydrate  (EXP,ISO)
tamibarotene  (ISO)
tamoxifen  (EXP,ISO)
terbinafine  (ISO)
Terfenadine  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
tetracyclines  (EXP)
thalidomide  (ISO)
thapsigargin  (EXP)
theophylline  (EXP,ISO)
thioacetamide  (ISO)
thiram  (EXP)
thromboxane B2  (ISO)
thymoquinone  (ISO)
titanium dioxide  (EXP,ISO)
TMC-120A  (EXP)
tofacitinib  (ISO)
tolnaftate  (ISO)
toluene  (EXP)
toluene 2,4-diisocyanate  (EXP,ISO)
trans-caffeic acid  (EXP)
trans-piceid  (ISO)
tremolite asbestos  (EXP)
tributylstannane  (ISO)
Tributyltin oxide  (ISO)
tributyrin  (EXP)
tricaproin  (EXP)
trichloroethene  (EXP,ISO)
triclosan  (EXP)
trimellitic anhydride  (EXP,ISO)
Triptolide  (EXP)
uranium atom  (EXP)
urethane  (EXP)
valproic acid  (ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
verrucarin A  (EXP)
vitamin D  (ISO)
vitamin E  (EXP,ISO)
WIN 55212-2  (ISO)
wortmannin  (ISO)
zearalenone  (ISO)
zidovudine  (ISO)
zileuton  (EXP)
zinc atom  (EXP,ISO)
zinc oxide  (ISO)
zinc(0)  (EXP,ISO)
ziram  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activated T cell proliferation  (IDA)
autophagy  (IEA)
B cell activation  (IDA,IEA)
B cell costimulation  (IDA)
B cell proliferation  (IDA)
cell surface receptor signaling pathway via JAK-STAT  (ISO)
cellular response to mercury ion  (ISO)
cholesterol metabolic process  (IMP)
defense response to protozoan  (IMP)
dendritic cell differentiation  (ISO)
extrinsic apoptotic signaling pathway  (IDA)
extrinsic apoptotic signaling pathway in absence of ligand  (IDA)
female pregnancy  (ISO)
immune response  (IEA)
innate immune response in mucosa  (IDA)
interleukin-4-mediated signaling pathway  (IBA,IDA,ISO)
isotype switching to IgE isotypes  (IDA)
isotype switching to IgG isotypes  (IDA)
leukocyte activation  (IEA)
macrophage activation  (ISO)
MHC class II biosynthetic process  (IDA)
microglial cell activation  (ISO)
myeloid dendritic cell differentiation  (ISO)
negative regulation of acute inflammatory response  (ISO)
negative regulation of cellular response to transforming growth factor beta stimulus  (ISO)
negative regulation of chronic inflammatory response  (ISO)
negative regulation of complement-dependent cytotoxicity  (ISO)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of endothelial cell apoptotic process  (ISO)
negative regulation of epithelial cell migration  (ISO)
negative regulation of extrinsic apoptotic signaling pathway  (IDA)
negative regulation of inflammatory response  (IBA,ISO)
negative regulation of leukocyte activation  (IEA)
negative regulation of macrophage activation  (ISO)
negative regulation of nitric oxide biosynthetic process  (ISO)
negative regulation of osteoclast differentiation  (IDA)
negative regulation of T cell activation  (IDA)
negative regulation of T-helper 17 cell differentiation  (IDA)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of tumor necrosis factor production  (IDA)
negative regulation of white fat cell proliferation  (IDA)
neuroinflammatory response  (ISO)
peptidyl-tyrosine phosphorylation  (IDA)
positive regulation of activated T cell proliferation  (IDA)
positive regulation of amyloid-beta clearance  (IDA,IEA,ISO)
positive regulation of ATP biosynthetic process  (IDA)
positive regulation of B cell activation  (IDA)
positive regulation of B cell chemotaxis  (IGI)
positive regulation of B cell proliferation  (IDA)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of cellular respiration  (IDA)
positive regulation of chemokine production  (IDA)
positive regulation of cold-induced thermogenesis  (IMP)
positive regulation of defense response to virus by host  (ISO)
positive regulation of DNA-templated transcription  (IBA,IDA,ISO)
positive regulation of eosinophil chemotaxis  (ISO)
positive regulation of establishment of endothelial barrier  (ISO)
positive regulation of gene expression  (IDA,IEA,ISO)
positive regulation of immunoglobulin production  (IGI,IMP)
positive regulation of interleukin-10 production  (ISO)
positive regulation of interleukin-13 production  (ISO)
positive regulation of isotype switching to IgE isotypes  (IDA)
positive regulation of isotype switching to IgG isotypes  (IDA)
positive regulation of leukocyte chemotaxis  (IEA)
positive regulation of macroautophagy  (IDA)
positive regulation of mast cell degranulation  (IGI,IMP)
positive regulation of MHC class II biosynthetic process  (IDA)
positive regulation of mononuclear cell migration  (IEA,ISO)
positive regulation of myoblast fusion  (IDA,IMP)
positive regulation of peptidyl-tyrosine phosphorylation  (IDA)
positive regulation of protein phosphorylation  (IDA,ISO)
positive regulation of reactive oxygen species biosynthetic process  (ISO)
positive regulation of receptor signaling pathway via JAK-STAT  (ISO)
positive regulation of receptor-mediated endocytosis  (IDA,IEA,ISO)
positive regulation of T cell differentiation  (ISO)
positive regulation of T cell proliferation  (IDA)
positive regulation of T-helper 2 cell cytokine production  (ISO)
positive regulation of transcription by RNA polymerase II  (IDA,IGI,ISO)
positive regulation of tyrosine phosphorylation of STAT protein  (IDA)
regulation of immune response  (IBA,IDA)
regulation of primary metabolic process  (IEA)
regulation of protein export from nucleus  (ISO)
regulation of proton transport  (ISO)
response to cytokine  (ISO)
response to ethanol  (ISO)
response to genistein  (ISO)
response to nematode  (IDA)
response to nutrient  (ISO)
response to selenium ion  (IDA)
response to xenobiotic stimulus  (ISO)
retina development in camera-type eye  (ISO)
T cell activation  (ISO)
T cell proliferation  (IDA)
T-helper 1 cell lineage commitment  (IGI)
T-helper 2 cell differentiation  (IDA)
transcription by RNA polymerase II  (IDA)
tyrosine phosphorylation of STAT protein  (IDA)

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal cell death  (IAGP)
abnormal circulating complement protein level  (IAGP)
abnormal cytokine secretion  (IAGP)
abnormal dendritic cell antigen presentation  (IAGP)
abnormal dendritic cell differentiation  (IAGP)
abnormal enzyme/coenzyme activity  (IAGP)
abnormal humoral immune response  (IAGP)
abnormal immune system physiology  (IAGP)
abnormal immunoglobulin level  (IAGP)
abnormal interleukin-4 secretion  (IAGP)
abnormal intestinal goblet cell morphology  (IAGP)
abnormal kidney physiology  (IAGP)
abnormal lymph node germinal center morphology  (IAGP)
abnormal lymph node size  (IAGP)
abnormal mammary gland growth during pregnancy  (IAGP)
abnormal mast cell physiology  (IAGP)
abnormal microglial cell morphology  (IAGP)
abnormal physiological response to xenobiotic  (IAGP)
abnormal response to infection  (IAGP)
abnormal salivary gland physiology  (IAGP)
abnormal skin physiology  (IAGP)
abnormal spleen size  (IAGP)
abnormal splenocyte physiology  (IAGP)
abnormal susceptibility to infection  (IAGP)
abnormal susceptibility to Riboviria infection  (IAGP)
abnormal T-helper 1 cell differentiation  (IAGP)
abnormal T-helper 2 cell differentiation  (IAGP)
abnormal T-helper 2 physiology  (IAGP)
alveolar process atrophy  (IAGP)
autoimmune response  (IAGP)
CNS inflammation  (IAGP)
decreased airway responsiveness  (IAGP)
decreased anti-nuclear antigen antibody level  (IAGP)
decreased B cell number  (IAGP)
decreased basophil cell number  (IAGP)
decreased circulating creatinine level  (IAGP)
decreased core body temperature  (IAGP)
decreased cytotoxic T cell cytolysis  (IAGP)
decreased eosinophil cell number  (IAGP)
decreased fatty acids level  (IAGP)
decreased IgA level  (IAGP)
decreased IgE level  (IAGP)
decreased IgG level  (IAGP)
decreased IgG1 level  (IAGP)
decreased IgG2a level  (IAGP)
decreased IgG2b level  (IAGP)
decreased IgG3 level  (IAGP)
decreased IgM level  (IAGP)
decreased immunoglobulin level  (IAGP)
decreased inflammatory response  (IAGP)
decreased interferon-gamma secretion  (IAGP)
decreased interleukin-10 secretion  (IAGP)
decreased interleukin-13 secretion  (IAGP)
decreased interleukin-3 secretion  (IAGP)
decreased interleukin-4 secretion  (IAGP)
decreased interleukin-5 secretion  (IAGP)
decreased noradrenaline level  (IAGP)
decreased susceptibility to autoimmune diabetes  (IAGP)
decreased susceptibility to autoimmune disorder  (IAGP)
decreased susceptibility to injury  (IAGP)
decreased susceptibility to parasitic infection  (IAGP)
decreased susceptibility to systemic lupus erythematosus  (IAGP)
emphysema  (IAGP)
enlarged spleen  (IAGP)
esophageal epithelium hyperplasia  (IAGP)
esophageal inflammation  (IAGP)
glomerulonephritis  (IAGP)
granulomatous inflammation  (IAGP)
ileum inflammation  (IAGP)
impaired eosinophil recruitment  (IAGP)
increased anti-double stranded DNA antibody level  (IAGP)
increased anti-nuclear antigen antibody level  (IAGP)
increased B cell proliferation  (IAGP)
increased basophil cell number  (IAGP)
increased CD4-positive, alpha-beta T cell number  (IAGP)
increased circulating alanine transaminase level  (IAGP)
increased circulating glucose level  (IAGP)
increased eosinophil cell number  (IAGP)
increased IgA level  (IAGP)
increased IgG level  (IAGP)
increased IgG2a level  (IAGP)
increased IgG2b level  (IAGP)
increased IgG2c level  (IAGP)
increased IgM level  (IAGP)
increased inflammatory response  (IAGP)
increased interferon-gamma secretion  (IAGP)
increased interleukin-13 secretion  (IAGP)
increased interleukin-2 secretion  (IAGP)
increased interleukin-5 secretion  (IAGP)
increased mast cell number  (IAGP)
increased neutrophil cell number  (IAGP)
increased pre-B cell number  (IAGP)
increased pro-B cell number  (IAGP)
increased spleen weight  (IAGP)
increased susceptibility to autoimmune disorder  (IAGP)
increased susceptibility to parasitic infection  (IAGP)
increased susceptibility to parasitic infection induced morbidity/mortality  (IAGP)
increased susceptibility to weight loss  (IAGP)
increased T cell number  (IAGP)
increased T cell proliferation  (IAGP)
insulitis  (IAGP)
lacrimal gland inflammation  (IAGP)
liver inflammation  (IAGP)
lung epithelium hyperplasia  (IAGP)
lung inflammation  (IAGP)
no abnormal phenotype detected  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
premature death  (IAGP)
salivary gland inflammation  (IAGP)
spleen hyperplasia  (IAGP)
stomach inflammation  (IAGP)
References

References - curated
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PMID:17579028   PMID:17579059   PMID:17586699   PMID:17601518   PMID:17611223   PMID:17623648   PMID:17646405   PMID:17670977   PMID:17764675   PMID:17785830   PMID:17855502   PMID:17875810  
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PMID:19587021   PMID:19592641   PMID:19606256   PMID:19635864   PMID:19638212   PMID:19638630   PMID:19646904   PMID:19666510   PMID:19667086   PMID:19682930   PMID:19692641   PMID:19710468  
PMID:19726720   PMID:19734227   PMID:19736385   PMID:19737861   PMID:19740328   PMID:19783672   PMID:19799897   PMID:19801646   PMID:19815118   PMID:19828636   PMID:19852819   PMID:19880493  
PMID:19881507   PMID:19888475   PMID:19891612   PMID:19893050   PMID:19950176   PMID:19955520   PMID:20018622   PMID:20042469   PMID:20042577   PMID:20052800   PMID:20053284   PMID:20080943  
PMID:20092813   PMID:20107184   PMID:20142430   PMID:20147633   PMID:20181883   PMID:20200518   PMID:20212093   PMID:20304823   PMID:20351140   PMID:20371618   PMID:20392496   PMID:20399120  
PMID:20418876   PMID:20439540   PMID:20490452   PMID:20495073   PMID:20495560   PMID:20504237   PMID:20512127   PMID:20513001   PMID:20525889   PMID:20534524   PMID:20562261   PMID:20564001  
PMID:20570861   PMID:20601599   PMID:20605978   PMID:20621581   PMID:20625006   PMID:20641004   PMID:20674402   PMID:20696860   PMID:20706986   PMID:20733201   PMID:20817571   PMID:20819925  
PMID:20819926   PMID:20821727   PMID:20869773   PMID:20870945   PMID:20889552   PMID:20937871   PMID:20944002   PMID:20944009   PMID:20944673   PMID:20956546   PMID:20974986   PMID:20976099  
PMID:21040544   PMID:21084663   PMID:21093321   PMID:21131966   PMID:21139679   PMID:21149710   PMID:21173308   PMID:21217760   PMID:21219110   PMID:21258007   PMID:21268009   PMID:21270410  
PMID:21282512   PMID:21285395   PMID:21307291   PMID:21346235   PMID:21383242   PMID:21398616   PMID:21436399   PMID:21460847   PMID:21464207   PMID:21468627   PMID:21471214   PMID:21480212  
PMID:21482696   PMID:21484783   PMID:21490158   PMID:21502330   PMID:21515798   PMID:21518876   PMID:21518974   PMID:21552267   PMID:21565523   PMID:21597016   PMID:21602491   PMID:21613615  
PMID:21624466   PMID:21636115   PMID:21646476   PMID:21699881   PMID:21731741   PMID:21734075   PMID:21741972   PMID:21751242   PMID:21799768   PMID:21820502   PMID:21824866   PMID:21841136  
PMID:21841801   PMID:21844388   PMID:21846901   PMID:21858226   PMID:21865055   PMID:21873635   PMID:21890374   PMID:21896015   PMID:21947361   PMID:21949021   PMID:21977998   PMID:21987655  
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PMID:22138715   PMID:22156496   PMID:22164245   PMID:22174447   PMID:22184721   PMID:22201618   PMID:22212899   PMID:22281511   PMID:22291593   PMID:22326582   PMID:22365664   PMID:22370606  
PMID:22396530   PMID:22403444   PMID:22412848   PMID:22492684   PMID:22504655   PMID:22543263   PMID:22574929   PMID:22634865   PMID:22645141   PMID:22677422   PMID:22682244   PMID:22685550  
PMID:22702477   PMID:22751694   PMID:22761864   PMID:22776139   PMID:22798672   PMID:22806101   PMID:22829596   PMID:22838967   PMID:22855601   PMID:22865229   PMID:22902947   PMID:22940186  
PMID:22941735   PMID:22966002   PMID:22966004   PMID:22980983   PMID:22987803   PMID:23006545   PMID:23027937   PMID:23029313   PMID:23039181   PMID:23041566   PMID:23071691   PMID:23107827  
PMID:23190881   PMID:23207180   PMID:23218741   PMID:23241885   PMID:23255589   PMID:23275605   PMID:23290520   PMID:23319739   PMID:23351078   PMID:23355737   PMID:23420878   PMID:23426944  
PMID:23434060   PMID:23490416   PMID:23509358   PMID:23536294   PMID:23543759   PMID:23545299   PMID:23552130   PMID:23582173   PMID:23582327   PMID:23624599   PMID:23643632   PMID:23686838  
PMID:23716674   PMID:23716700   PMID:23733879   PMID:23757302   PMID:23761633   PMID:23772040   PMID:23776171   PMID:23776174   PMID:23785119   PMID:23797092   PMID:23804713   PMID:23810766  
PMID:23837489   PMID:23851689   PMID:23871207   PMID:23880769   PMID:23913966   PMID:23935453   PMID:23954132   PMID:23990998   PMID:23991011   PMID:24043894   PMID:24051241   PMID:24076050  
PMID:24097110   PMID:24100031   PMID:24100592   PMID:24101381   PMID:24138883   PMID:24139608   PMID:24166713   PMID:24166714   PMID:24166975   PMID:24210353   PMID:24280725   PMID:24281564  
PMID:24281729   PMID:24314139   PMID:24325354   PMID:24336249   PMID:24347527   PMID:24367028   PMID:24486724   PMID:24489947   PMID:24550295   PMID:24563216   PMID:24578067   PMID:24589747  
PMID:24613091   PMID:24620029   PMID:24623351   PMID:24631157   PMID:24634489   PMID:24643536   PMID:24647735   PMID:24677019   PMID:24698321   PMID:24723460   PMID:24750795   PMID:24781052  
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PMID:25328047   PMID:25336167   PMID:25404305   PMID:25416814   PMID:25441650   PMID:25489003   PMID:25493691   PMID:25495255   PMID:25535377   PMID:25545131   PMID:25574039   PMID:25605931  
PMID:25607842   PMID:25611587   PMID:25648335   PMID:25751266   PMID:25772794   PMID:25779634   PMID:25780046   PMID:25801306   PMID:25816012   PMID:25888258   PMID:25908537   PMID:25912172  
PMID:25944087   PMID:25981357   PMID:25992862   PMID:26039103   PMID:26079835   PMID:26088754   PMID:26092469   PMID:26098997   PMID:26124135   PMID:26129648   PMID:26130091   PMID:26188063  
PMID:26192556   PMID:26195478   PMID:26269636   PMID:26278622   PMID:26280119   PMID:26287681   PMID:26299987   PMID:26362265   PMID:26363056   PMID:26410627   PMID:26410628   PMID:26416964  
PMID:26428678   PMID:26436920   PMID:26452143   PMID:26456931   PMID:26491200   PMID:26523376   PMID:26538310   PMID:26540411   PMID:26582947   PMID:26628680   PMID:26644468   PMID:26673140  
PMID:26675736   PMID:26688514   PMID:26703455   PMID:26732561   PMID:26750312   PMID:26825674   PMID:26840450   PMID:26872695   PMID:26896776   PMID:26900854   PMID:26918372   PMID:26951334  
PMID:27034374   PMID:27049063   PMID:27102638   PMID:27114284   PMID:27117406   PMID:27154637   PMID:27177780   PMID:27240831   PMID:27259856   PMID:27273006   PMID:27298446   PMID:27302755  
PMID:27315109   PMID:27357235   PMID:27409813   PMID:27421703   PMID:27432189   PMID:27457412   PMID:27474166   PMID:27479084   PMID:27487182   PMID:27551096   PMID:27554818   PMID:27573866  
PMID:27599561   PMID:27626662   PMID:27643438   PMID:27659424   PMID:27721424   PMID:27721447   PMID:27745702   PMID:27749840   PMID:27760339   PMID:27815425   PMID:27837109   PMID:27872905  
PMID:27913566   PMID:27920023   PMID:27956120   PMID:27977701   PMID:27995420   PMID:28051111   PMID:28096407   PMID:28115531   PMID:28137851   PMID:28192541   PMID:28202459   PMID:28202615  
PMID:28206989   PMID:28223293   PMID:28234975   PMID:28257233   PMID:28302646   PMID:28315756   PMID:28327619   PMID:28416503   PMID:28431248   PMID:28490634   PMID:28495878   PMID:28507062  
PMID:28533444   PMID:28580955   PMID:28684424   PMID:28716804   PMID:28725048   PMID:28730605   PMID:28733709   PMID:28765368   PMID:28801358   PMID:28847007   PMID:28869965   PMID:28875978  
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PMID:31341159   PMID:31371561   PMID:31399281   PMID:31481522   PMID:31505056   PMID:31776260   PMID:31825972   PMID:31924686   PMID:31953450   PMID:31980518   PMID:31983537   PMID:32014112  
PMID:32127173   PMID:32160524   PMID:32240850   PMID:32366355   PMID:32406065   PMID:32424366   PMID:32434080   PMID:32444388   PMID:32528242   PMID:32561567   PMID:32686763   PMID:32721946  
PMID:32735846   PMID:32745297   PMID:32807943   PMID:32917785   PMID:33017719   PMID:33020569   PMID:33069715   PMID:33077427   PMID:33086036   PMID:33098765   PMID:33101290   PMID:33239419  
PMID:33247472   PMID:33309741   PMID:33328477   PMID:33338687   PMID:33662369   PMID:33720008   PMID:34006897   PMID:34061992   PMID:34126239   PMID:34168190   PMID:34196299   PMID:34226412  
PMID:34326478   PMID:34632444   PMID:34707292   PMID:34717799   PMID:34793707   PMID:34795444   PMID:34804014   PMID:34815787   PMID:34852236   PMID:34863091   PMID:34868049   PMID:34890253  
PMID:34958108   PMID:34965421   PMID:35114487   PMID:35154068   PMID:35288169   PMID:35301301   PMID:35355990   PMID:35359977   PMID:35442154   PMID:35493520   PMID:35505616   PMID:35587822  
PMID:35657353   PMID:35767958   PMID:35768001   PMID:35794484   PMID:35844602   PMID:35881515   PMID:35911733   PMID:35926464   PMID:36002023   PMID:36044899   PMID:36063138   PMID:36171294  
PMID:36240286   PMID:36323312   PMID:36330506   PMID:36539414   PMID:36541656   PMID:36720287   PMID:36753434   PMID:36914076   PMID:37021574   PMID:37163450   PMID:37174683   PMID:37380774  
PMID:37676935   PMID:37699392   PMID:37783432   PMID:37827277   PMID:37887277   PMID:37918358   PMID:38030609   PMID:38040679   PMID:38057662   PMID:38081605   PMID:38135009   PMID:38180236  
PMID:38241965   PMID:38262419   PMID:38286436   PMID:38323641   PMID:38354709   PMID:38373380   PMID:38442268   PMID:38513666   PMID:38536932   PMID:38574142   PMID:38608055   PMID:38613873  
PMID:38614090   PMID:38649353   PMID:38724220   PMID:38761804   PMID:38780542   PMID:39088319   PMID:39287443   PMID:39297875   PMID:39350473   PMID:39367406   PMID:39515094   PMID:39744942  
PMID:39889704   PMID:40011469   PMID:40013943   PMID:40139187   PMID:40292307  


Genomics

Comparative Map Data
Il4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391153,503,287 - 53,509,492 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1153,493,809 - 53,509,496 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381153,612,460 - 53,618,665 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1153,602,982 - 53,618,669 (-)Ensemblmm10GRCm38
MGSCv371153,425,962 - 53,432,167 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361153,455,891 - 53,462,088 (-)NCBIMGSCv36mm8
Celera1158,191,990 - 58,198,195 (-)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1131.97NCBI
IL4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385132,673,989 - 132,682,678 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5132,673,986 - 132,682,678 (+)Ensemblhg38GRCh38
GRCh375132,009,681 - 132,018,370 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365132,037,272 - 132,046,267 (+)NCBIBuild 36Build 36hg18NCBI36
Build 345132,037,271 - 132,046,267NCBI
Celera5128,139,502 - 128,148,524 (+)NCBICelera
Cytogenetic Map5q31.1NCBI
HuRef5127,201,979 - 127,210,672 (+)NCBIHuRef
CHM1_15131,442,973 - 131,451,670 (+)NCBICHM1_1
T2T-CHM13v2.05133,193,788 - 133,202,478 (+)NCBIT2T-CHM13v2.0
Il4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81038,272,003 - 38,277,549 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1038,272,003 - 38,277,549 (-)EnsemblGRCr8
mRatBN7.21037,771,203 - 37,776,750 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1037,771,203 - 37,776,750 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1042,463,191 - 42,468,731 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01041,953,256 - 41,958,796 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01037,456,988 - 37,462,524 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01038,963,979 - 38,969,531 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1038,963,979 - 38,969,531 (-)Ensemblrn6Rnor6.0
Rnor_5.01038,745,706 - 38,751,258 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41039,074,582 - 39,080,134 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1037,115,496 - 37,120,965 (-)NCBICelera
RGSC_v3.11039,083,152 - 39,088,705 (-)NCBI
Cytogenetic Map10q22NCBI
Il4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554084,058,052 - 4,064,185 (+)Ensembl
ChiLan1.0NW_0049554084,058,052 - 4,065,999 (+)NCBIChiLan1.0ChiLan1.0
IL4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24127,986,571 - 127,995,112 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15126,126,136 - 126,134,677 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05128,091,342 - 128,099,886 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15134,253,039 - 134,261,581 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5134,253,039 - 134,261,581 (+)EnsemblpanPan2panpan1.1
IL4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11120,972,693 - 20,981,539 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1120,972,690 - 20,981,534 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1119,774,149 - 19,783,205 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01121,758,633 - 21,767,487 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1121,758,630 - 21,767,482 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11120,477,129 - 20,485,985 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01120,324,686 - 20,333,537 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01120,967,178 - 20,976,037 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
IL4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2134,986,817 - 134,994,365 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.12134,986,817 - 134,994,365 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22140,455,331 - 140,462,879 (+)NCBISscrofa10.2Sscrofa10.2susScr3
IL4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12335,492,158 - 35,501,349 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2335,492,939 - 35,501,258 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603442,443,750 - 42,449,550 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Il4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473339,412,800 - 39,420,079 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Il4
264 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:686
Count of miRNA genes:311
Interacting mature miRNAs:344
Transcripts:ENSMUST00000000889, ENSMUST00000127858, ENSMUST00000140684, ENSMUST00000150568
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357844Si5lq5_mserum IGFBP-5 level QTL 5 (mouse)Not determined112816587362165976Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44630038113058009Mouse
1357720Kidpq1_mkidney weight percentage QTL 1 (mouse)Not determined111226863768500330Mouse
1300765Bbaa4_mB.burgdorferi-associated arthritis 4 (mouse)Not determined114618516780185262Mouse
1357851Scfq3_msubcutaneous fat pad weight QTL 3 (mouse)Not determined111226863768500330Mouse
1301788Lbw8_mlupus NZB x NZW 8 (mouse)Not determined113650328770509492Mouse
27226762Feml21_mfemur length 21, 16 week (mouse)111175000065990826Mouse
1302021Nidd1n_mnon-insulin-dependent diabetes mellitus 1 in NSY (mouse)Not determined114516587379978324Mouse
1301896Tria1_mT-cell receptor induced activation 1 (mouse)Not determined113661356570613855Mouse
4141470Egq4_mearly growth QTL 4 (mouse)Not determined1226863768500330Mouse
1301426Desp2_mdespair 2 (mouse)Not determined112870858162708700Mouse
4142109W10q2_mweight 10 weeks QTL 2 (mouse)Not determined1226863768500330Mouse
4141853Skmw17_mskeletal muscle weight 17 (mouse)Not determined113708094171081064Mouse
1357878Mastr_mmodifier of astrocytoma (mouse)Not determined114570858189818733Mouse
13208559Wght10_mweight 10 (mouse)11395000088890826Mouse
13524840Ppiq9a_mprepulse inhibition QTL 9a (mouse)115249438586494385Mouse
13208558Lgth12_mbody length 12 (mouse)11395000094890826Mouse
26884401Huml4_mhumerus length 4, 10 week (mouse)111155000068490826Mouse
10053687Eae6_msusceptibility to experimental allergic encephalomyelitis 6 (mouse)Not determined111778196668500330Mouse
13208569Bmiq10_mbody mass index QTL 10 (mouse)113589082784890826Mouse
27226798Scvln18_msacral vertebrae length 2, 16 week (mouse)11325000060690826Mouse
4141582Lgaq1_mlate growth adjusted QTL 1 (mouse)Not determined1226863768500330Mouse
4141966Tailq1_mtail length QTL 1 (mouse)Not determined1226863768500330Mouse
10053675Eae44b_mexperimental allergic encephalomyelitis susceptibility 44b (mouse)Not determined113995072854094448Mouse
4142475Ity2a_mimmunity to S. typhimurium 2a (mouse)Not determined113776858060402716Mouse
11532699Sluc36b_msusceptibility to lung cancer 36b (mouse)114225661776256730Mouse
11532698Sluc36a_msusceptibility to lung cancer 36a (mouse)114225661776256730Mouse
1300774Pgia7_mproteoglycan induced arthritis 7 (mouse)Not determined115339058887390737Mouse
1558945Orgwq8_morgan weight QTL 8 (mouse)Not determined111705617567078411Mouse
4142216Lgq1_mlate growth QTL 1 (mouse)Not determined1226863768500330Mouse
1300905Scc6_mcolon tumor susceptibility 6 (mouse)Not determined11688027789019734Mouse
14746971Manh70_mmandible shape 70 (mouse)111990589053905890Mouse
13524848Ppiq7_mprepulse inhibition QTL 7 (mouse)112856914762569147Mouse
1357782Char8_mP. chabaudi malaria resistance QTL 8 (mouse)Not determined113557861669684987Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
11059563Lmr31_mleishmaniasis resistance 31 (mouse)113210057766100694Mouse
1301328Mol4_mmodifier of LPS-response 4 (mouse)Not determined113628257783481356Mouse
26884446Sklq10_mskull length QTL 10, 10 week (mouse)11325000062890826Mouse
10412246Dfs2_mdental fluorosis suseptibility 2 (mouse)Not determined112180736495881231Mouse
1559002Lmrq4_mLeishmania major resistance QTL 4 (mouse)Not determined111226863769684947Mouse
1301830Ssta4_msusceptibility to Salmonella typhimurium antigens 4 (mouse)Not determined115007819184078411Mouse
4142308W6q3_mweight 6 weeks QTL 3 (mouse)Not determined111226863768500330Mouse
1357640Orq2_movulation rate QTL 2 (mouse)Not determined111226863768500330Mouse
10766457Nwa3_mNew Zealand White autoimmunity 3 (mouse)113801611572016209Mouse
4142300Ctrq3_mC. trachomatis resistance QTL 3 (mouse)Not determined114463003876854757Mouse
1357437Epfq4_mepididymal fat pad weight QTL 4 (mouse)Not determined111226863768500330Mouse
4141398Tgq22_mtriglyceride QTL 22 (mouse)Not determined2116340655163406Mouse
27226738Metcl11_mmetatarsal-calcaneal length 11, 10 week (mouse)11885000061390826Mouse
11522752Cocia18_mcocaine-induced activity, QTL 18 (mouse)113100820965008209Mouse
4141770Tcpm1_mT-cell phenotype modifier 1 (mouse)Not determined5145247953615930Mouse
1301988Bmd11_mbone mineral density 11 (mouse)Not determined114631940780319522Mouse
4141127W3q4_mweight 3 weeks QTL 4 (mouse)Not determined1226863768500330Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1912420496897826Mouse
1300713Vmbic10_mventral midbrain iron content 10 (mouse)Not determined114277262654081064Mouse
26884453Sklq16_mskull length QTL 16, 16 week (mouse)11325000072690826Mouse
10044006Hbnr13_mHeligmosomoides bakeri nematode resistance 13 (mouse)Not determined112577262659772741Mouse

Markers in Region
D11Mit111  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381153,618,045 - 53,618,173UniSTSGRCm38
MGSCv371153,431,547 - 53,431,675UniSTSGRCm37
Celera1158,197,575 - 58,197,703UniSTS
Cytogenetic Map11B1.3UniSTS
cM Map1127.9UniSTS
Whitehead Genetic1125.1UniSTS
Whitehead_YAC11 UniSTS
Il4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv371153,431,546 - 53,431,654UniSTSGRCm37
MGSCv371153,432,276 - 53,432,423UniSTSGRCm37
Celera1158,197,574 - 58,197,682UniSTS
Celera1158,198,304 - 58,198,451UniSTS
Cytogenetic Map11B1.3UniSTS
cM Map1129.0UniSTS
cM Map1129.0UniSTS
cM Map1129.0UniSTS
cM Map762.0UniSTS
cM Map1129.0UniSTS
Il4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11B1.3UniSTS
cM Map1129.0UniSTS
Il4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381153,618,044 - 53,618,152UniSTSGRCm38
MGSCv371153,431,546 - 53,431,654UniSTSGRCm37
Celera1158,197,574 - 58,197,682UniSTS
Cytogenetic Map11B1.3UniSTS
cM Map1129.0UniSTS
Il4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381153,618,774 - 53,618,921UniSTSGRCm38
MGSCv371153,432,276 - 53,432,423UniSTSGRCm37
Celera1158,198,304 - 58,198,451UniSTS
Cytogenetic Map11B1.3UniSTS
cM Map1129.0UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_021283 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_027491 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA199406 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB174765 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC005742 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF352783 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF359558 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL596095 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL645741 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC027514 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX529138 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466575 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M13238 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M25892 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U07869 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X03532 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X05064 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X05252 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X05253 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000000889   ⟹   ENSMUSP00000000889
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1153,503,287 - 53,509,496 (-)Ensembl
GRCm38.p6 Ensembl1153,612,460 - 53,618,669 (-)Ensembl
Ensembl Acc Id: ENSMUST00000127858
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1153,493,809 - 53,508,051 (-)Ensembl
GRCm38.p6 Ensembl1153,602,982 - 53,617,224 (-)Ensembl
Ensembl Acc Id: ENSMUST00000140684   ⟹   ENSMUSP00000133617
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1153,503,287 - 53,509,179 (-)Ensembl
GRCm38.p6 Ensembl1153,612,460 - 53,618,352 (-)Ensembl
Ensembl Acc Id: ENSMUST00000150568   ⟹   ENSMUSP00000134414
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1153,503,287 - 53,508,165 (-)Ensembl
GRCm38.p6 Ensembl1153,612,460 - 53,617,338 (-)Ensembl
RefSeq Acc Id: NM_021283   ⟹   NP_067258
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391153,503,287 - 53,509,492 (-)NCBI
GRCm381153,612,460 - 53,618,665 (-)ENTREZGENE
MGSCv371153,425,962 - 53,432,167 (-)RGD
Celera1158,191,990 - 58,198,195 (-)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_027491
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391153,503,287 - 53,508,165 (-)NCBI
GRCm381153,612,460 - 53,617,338 (-)NCBI
MGSCv371153,425,962 - 53,432,167 (-)RGD
Celera1158,191,990 - 58,198,195 (-)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_067258   ⟸   NM_021283
- Peptide Label: precursor
- UniProtKB: P07750 (UniProtKB/Swiss-Prot),   Q91Y50 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000134414   ⟸   ENSMUST00000150568
Ensembl Acc Id: ENSMUSP00000000889   ⟸   ENSMUST00000000889
Ensembl Acc Id: ENSMUSP00000133617   ⟸   ENSMUST00000140684

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P07750-F1-model_v2 AlphaFold P07750 1-140 view protein structure

Promoters
RGD ID:6850124
Promoter ID:EP15039
Type:single initiation site
Name:MM_IL4
Description:Interleukin-4, B-cell stimulating factor-1, IL4 OR IL-4 gene.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Notes:homology_group=Homology group 151; Mammalian interleukin-4
Experiment Methods:Nuclease protection with homologous sequence ladder
Regulation:helper T (repressed by or weakly expressed in) cells II; (induced by or strongly expressed in) antigen
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv371153,432,171 - 53,432,231EPD
MGSCv361153,432,171 - 53,432,231EPD
RGD ID:8674616
Promoter ID:EPDNEW_M15339
Type:multiple initiation site
Name:Il4_1
Description:Mus musculus interleukin 4 , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M15340  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381153,617,359 - 53,617,419EPDNEW
RGD ID:8674618
Promoter ID:EPDNEW_M15340
Type:single initiation site
Name:Il4_2
Description:Mus musculus interleukin 4 , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M15339  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381153,618,663 - 53,618,723EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:96556 AgrOrtholog
Ensembl Genes ENSMUSG00000000869 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000000889 ENTREZGENE
  ENSMUST00000000889.7 UniProtKB/Swiss-Prot
  ENSMUST00000150568 ENTREZGENE
Gene3D-CATH 1.20.1250.10 UniProtKB/Swiss-Prot
InterPro 4_helix_cytokine-like_core UniProtKB/Swiss-Prot
  IL-4 UniProtKB/Swiss-Prot
  IL-4/IL-13 UniProtKB/Swiss-Prot
  IL-4/IL-13_CS UniProtKB/Swiss-Prot
KEGG Report mmu:16189 UniProtKB/Swiss-Prot
MGD MGI:96556 ENTREZGENE
NCBI Gene 16189 ENTREZGENE
PANTHER INTERLEUKIN-4 UniProtKB/Swiss-Prot
  PTHR47401 UniProtKB/Swiss-Prot
Pfam IL4 UniProtKB/Swiss-Prot
PhenoGen Il4 PhenoGen
PIRSF Interleukin_4 UniProtKB/Swiss-Prot
PRINTS INTERLEUKIN4 UniProtKB/Swiss-Prot
PROSITE INTERLEUKIN_4_13 UniProtKB/Swiss-Prot
SMART IL4_13 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47266 UniProtKB/Swiss-Prot
UniProt G3UXB0_MOUSE UniProtKB/TrEMBL
  IL4_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q91Y50 ENTREZGENE, UniProtKB/TrEMBL