Igfbp2 (insulin-like growth factor binding protein 2) - Rat Genome Database

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Gene: Igfbp2 (insulin-like growth factor binding protein 2) Mus musculus
Analyze
Symbol: Igfbp2
Name: insulin-like growth factor binding protein 2
RGD ID: 10771
MGI Page MGI
Description: Enables insulin-like growth factor binding activity. Predicted to be involved in positive regulation of activated T cell proliferation and regulation of insulin-like growth factor receptor signaling pathway. Predicted to act upstream of or within negative regulation of osteoblast differentiation and osteoblast differentiation. Located in extracellular space. Is expressed in several structures, including brain; early embryo; limb; metanephros; and reproductive system. Human ortholog(s) of this gene implicated in obesity. Orthologous to human IGFBP2 (insulin like growth factor binding protein 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AI255832; IBP-2; IGF-binding protein 2; IGFBP; Igfbp-2; insulin-like growth factor-binding protein 2; mIGFBP-2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39172,863,650 - 72,891,633 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl172,863,662 - 72,891,633 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38172,824,480 - 72,852,474 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl172,824,503 - 72,852,474 (+)Ensemblmm10GRCm38
MGSCv37172,871,078 - 72,899,048 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36172,756,390 - 72,785,681 (+)NCBIMGSCv36mm8
Celera173,392,679 - 73,420,660 (+)NCBICelera
Cytogenetic Map1C3NCBI
cM Map136.94NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (EXP)
(S)-nicotine  (ISO)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2-hydroxypropanoic acid  (ISO)
2-nitrotoluene  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',4,4'-tetrachlorobiphenyl  (EXP)
3,3',5-triiodo-L-thyronine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-hydroxyphenyl retinamide  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (EXP)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-propyl-2-thiouracil  (ISO)
9-cis-retinoic acid  (ISO)
acrylamide  (EXP,ISO)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
ammonium chloride  (ISO)
Ampullosporin  (ISO)
anthracen-2-amine  (ISO)
antimycin A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
Azoxymethane  (EXP)
azoxystrobin  (ISO)
benzbromarone  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (EXP)
benzo[e]pyrene  (ISO)
Benzo[k]fluoranthene  (EXP)
beta-naphthoflavone  (ISO)
bexarotene  (ISO)
bicalutamide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bromobenzene  (ISO)
bromochloroacetic acid  (EXP,ISO)
Butylbenzyl phthalate  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
carbon nanotube  (EXP)
carbonyl sulfide  (ISO)
chlorohydrocarbon  (ISO)
chloropicrin  (ISO)
ciprofibrate  (EXP)
cisplatin  (ISO)
clobetasol  (EXP)
clofibrate  (ISO)
cocaine  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (EXP)
Cuprizon  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
deguelin  (ISO)
dexamethasone  (ISO)
dextran sulfate  (EXP)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (EXP)
dibutyl phthalate  (EXP,ISO)
diclofenac  (EXP)
diethyl phthalate  (EXP)
diethylstilbestrol  (EXP,ISO)
diisobutyl phthalate  (EXP)
diisononyl phthalate  (EXP)
dioxygen  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
ellagic acid  (ISO)
endosulfan  (ISO)
Enterolactone  (ISO)
erythromycin estolate  (ISO)
ethanol  (ISO)
fenpyroximate  (ISO)
fentin chloride  (ISO)
fluoxetine  (ISO)
flutamide  (ISO)
furan  (ISO)
genistein  (EXP)
gentamycin  (ISO)
glycidol  (ISO)
griseofulvin  (EXP)
GSK-J4  (ISO)
hexachlorobenzene  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
ivermectin  (ISO)
ketamine  (ISO)
L-ethionine  (ISO)
leflunomide  (ISO)
lidocaine  (ISO)
lipopolysaccharide  (EXP)
lycopene  (ISO)
menadione  (EXP)
methapyrilene  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
monobenzyl phthalate  (EXP)
Monobutylphthalate  (EXP)
monoethyl phthalate  (EXP)
N-(6-acetamidohexyl)acetamide  (EXP)
N-acetyl-L-cysteine  (ISO)
N-methyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (ISO)
nickel atom  (ISO)
nicotine  (ISO)
nitrofen  (ISO)
okadaic acid  (ISO)
omeprazole  (ISO)
ozone  (EXP,ISO)
p-menthan-3-ol  (ISO)
paracetamol  (EXP,ISO)
perfluorohexanesulfonic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
phenformin  (ISO)
phenobarbital  (EXP,ISO)
PhIP  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
progesterone  (ISO)
pyrimidifen  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
riddelliine  (ISO)
rotenone  (ISO)
RU 58668  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
silver atom  (EXP)
silver(0)  (EXP)
sodium arsenate  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium tungstate  (ISO)
streptozocin  (ISO)
sunitinib  (ISO)
tamibarotene  (ISO)
tamoxifen  (EXP,ISO)
tebufenpyrad  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
tetracycline  (EXP)
thapsigargin  (ISO)
thimerosal  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP,ISO)
triclosan  (ISO)
trimellitic anhydride  (EXP)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
tunicamycin  (ISO)
valproic acid  (EXP,ISO)
vemurafenib  (ISO)
vitamin E  (ISO)
vorinostat  (EXP)
zinc atom  (ISO)
zinc oxide  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
apical plasma membrane  (IEA,ISO)
extracellular region  (IEA,ISO,ISS)
extracellular space  (HDA,IBA,IDA,IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Comparative analysis of aqueous humor cytokine levels between patients with exudative age-related macular degeneration and normal controls. Cha DM, etal., Invest Ophthalmol Vis Sci. 2013 Oct 25;54(10):7038-44. doi: 10.1167/iovs.13-12730.
2. Roles of insulin-like growth factor (IGF) binding proteins in regulating IGF actions. Duan C and Xu Q, Gen Comp Endocrinol. 2005 May 15;142(1-2):44-52. Epub 2005 Feb 5.
3. Insulin-like growth factor binding protein-2 (IGFBP-2) is a marker for the metabolic syndrome. Heald AH, etal., Exp Clin Endocrinol Diabetes. 2006 Jul;114(7):371-6.
4. Microarray analysis of hippocampal gene expression in global cerebral ischemia. Jin K, etal., Ann Neurol. 2001 Jul;50(1):93-103.
5. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
6. Expression of insulin-like growth factor binding proteins in the rat kidney: effects of long-term diabetes. Landau D, etal., Endocrinology. 1995 May;136(5):1835-42. doi: 10.1210/endo.136.5.7536658.
7. Perinatal growth disturbance in the spontaneously hypertensive rat. Lewis RM, etal., Pediatr Res. 1997 Dec;42(6):758-64.
8. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
9. MGDs mouse GO annotations MGD data from the GO Consortium
10. MGD IEA MGD IEA
11. Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling. Moloney AM, etal., Neurobiol Aging. 2010 Feb;31(2):224-43. doi: 10.1016/j.neurobiolaging.2008.04.002. Epub .
12. Expression profile of IGF system during lung injury and recovery in rats exposed to hyperoxia: a possible role of IGF-1 in alveolar epithelial cell proliferation and differentiation. Narasaraju TA, etal., J Cell Biochem. 2006 Apr 1;97(5):984-98.
13. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
14. Influence of hypothyroidism on circulating concentrations and liver expression of IGF-binding proteins mRNA from neonatal and adult rats. Ramos S, etal., J Endocrinol. 2002 Feb;172(2):363-73.
15. Effect of weight loss on free insulin-like growth factor-I in obese women with hyposomatotropism. Rasmussen MH, etal., Obesity (Silver Spring). 2007 Apr;15(4):879-86.
16. Mouse MP Annotation Import Pipeline RGD automated import pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. IGF-binding protein-2 protects against the development of obesity and insulin resistance. Wheatcroft SB, etal., Diabetes. 2007 Feb;56(2):285-94.
Additional References at PubMed
PMID:1712312   PMID:7510294   PMID:7510770   PMID:7511095   PMID:7525256   PMID:7525452   PMID:7529732   PMID:7545402   PMID:7679139   PMID:7680327   PMID:7684980   PMID:7750499  
PMID:8358865   PMID:8398121   PMID:8751373   PMID:8832579   PMID:8923818   PMID:9093203   PMID:9175833   PMID:9275078   PMID:9324049   PMID:9551868   PMID:9685224   PMID:9785199  
PMID:10349636   PMID:10502456   PMID:10579311   PMID:10579362   PMID:10611375   PMID:10744620   PMID:10888943   PMID:10926090   PMID:10976924   PMID:11042159   PMID:11076861   PMID:11180952  
PMID:11316754   PMID:11698278   PMID:12115247   PMID:12123805   PMID:12409314   PMID:12477932   PMID:12520002   PMID:12834871   PMID:12904583   PMID:12914536   PMID:12933651   PMID:14610273  
PMID:14710363   PMID:14744882   PMID:15044367   PMID:15474485   PMID:15721138   PMID:15760467   PMID:16047381   PMID:16141072   PMID:16141073   PMID:16261417   PMID:16338473   PMID:16556765  
PMID:16602821   PMID:17255210   PMID:18276763   PMID:18287559   PMID:18392786   PMID:18450962   PMID:18799693   PMID:19095771   PMID:19142966   PMID:19334288   PMID:20074524   PMID:20111592  
PMID:20436479   PMID:20501873   PMID:20730703   PMID:20858761   PMID:21153277   PMID:21267068   PMID:21372140   PMID:21821709   PMID:21873635   PMID:22006816   PMID:22096492   PMID:22202803  
PMID:22410287   PMID:22496664   PMID:22688304   PMID:22869525   PMID:22967998   PMID:22973541   PMID:23525041   PMID:23563309   PMID:23813480   PMID:23981771   PMID:23981772   PMID:24006456  
PMID:24108661   PMID:24154525   PMID:24191913   PMID:24359611   PMID:24391734   PMID:24424049   PMID:24839202   PMID:24952961   PMID:24990151   PMID:25695641   PMID:25787077   PMID:25810521  
PMID:26105006   PMID:26134413   PMID:26230658   PMID:26244796   PMID:26507795   PMID:26556533   PMID:26773517   PMID:26930384   PMID:27125842   PMID:27126637   PMID:27224923   PMID:27544574  
PMID:27732088   PMID:27861515   PMID:29463737   PMID:29665134   PMID:29891551   PMID:30347220   PMID:30677223   PMID:31560714   PMID:31832311   PMID:31924792   PMID:32168373   PMID:32228319  
PMID:32325033   PMID:32532003   PMID:32993096   PMID:33632817   PMID:33763996   PMID:33948578   PMID:34003106   PMID:34359856   PMID:35226161   PMID:35741102   PMID:36343245   PMID:36734036  
PMID:36787736   PMID:36934380   PMID:37029430   PMID:37146585   PMID:37453365   PMID:38506034   PMID:38796567   PMID:39029468   PMID:39117630   PMID:39627352   PMID:39716738  


Genomics

Comparative Map Data
Igfbp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39172,863,650 - 72,891,633 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl172,863,662 - 72,891,633 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38172,824,480 - 72,852,474 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl172,824,503 - 72,852,474 (+)Ensemblmm10GRCm38
MGSCv37172,871,078 - 72,899,048 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36172,756,390 - 72,785,681 (+)NCBIMGSCv36mm8
Celera173,392,679 - 73,420,660 (+)NCBICelera
Cytogenetic Map1C3NCBI
cM Map136.94NCBI
IGFBP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382216,632,828 - 216,664,436 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2216,632,828 - 216,664,436 (+)Ensemblhg38GRCh38
GRCh372217,497,551 - 217,529,159 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362217,206,372 - 217,237,404 (+)NCBIBuild 36Build 36hg18NCBI36
Build 342217,323,632 - 217,354,665NCBI
Celera2211,266,003 - 211,297,047 (+)NCBICelera
Cytogenetic Map2q35NCBI
HuRef2209,352,529 - 209,383,563 (+)NCBIHuRef
CHM1_12217,504,294 - 217,535,337 (+)NCBICHM1_1
T2T-CHM13v2.02217,115,243 - 217,146,861 (+)NCBIT2T-CHM13v2.0
Igfbp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8981,864,811 - 81,892,179 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl981,864,783 - 81,892,171 (+)EnsemblGRCr8
mRatBN7.2974,415,574 - 74,442,945 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl974,415,546 - 74,442,937 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx982,870,444 - 82,897,811 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0987,999,330 - 88,026,694 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0986,386,056 - 86,413,442 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0980,118,029 - 80,144,804 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl980,118,029 - 80,144,789 (+)Ensemblrn6Rnor6.0
Rnor_5.0979,888,642 - 79,915,196 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4971,966,877 - 71,994,211 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera972,008,814 - 72,036,115 (+)NCBICelera
RGSC_v3.1972,113,854 - 72,141,188 (+)NCBI
Cytogenetic Map9q33NCBI
Igfbp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545316,557,194 - 16,584,634 (-)Ensembl
ChiLan1.0NW_00495545316,556,873 - 16,584,737 (-)NCBIChiLan1.0ChiLan1.0
IGFBP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213119,259,714 - 119,292,783 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B119,276,573 - 119,307,747 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B103,893,724 - 103,925,318 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B222,498,392 - 222,527,302 (+)NCBIPanPan1.1PanPan1.1panPan2
IGFBP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13723,553,227 - 23,569,321 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3723,559,501 - 23,569,312 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3724,374,276 - 24,397,898 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03723,573,472 - 23,597,135 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3723,573,472 - 23,596,810 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13723,456,971 - 23,480,636 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03723,417,432 - 23,433,721 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03723,436,098 - 23,452,395 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Igfbp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303171,929,066 - 171,954,100 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936586672,091 - 696,692 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936586671,760 - 696,783 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IGFBP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15118,822,047 - 118,850,976 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.115118,822,092 - 118,850,985 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
IGFBP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110102,469,611 - 102,503,229 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10102,469,669 - 102,503,276 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604096,906,056 - 96,936,013 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Igfbp2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248238,460,553 - 8,486,495 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248238,460,968 - 8,486,495 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

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Variants in Igfbp2
1815 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:569
Count of miRNA genes:247
Interacting mature miRNAs:273
Transcripts:ENSMUST00000047328, ENSMUST00000120564, ENSMUST00000155703
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11039528Ccc3_mcolitis susceptibility in the Collaborative Cross 3 (mouse)13680142195051546Mouse
4141625Emo4_memotionality 4 (mouse)Not determined6807134586235027Mouse
18182931Metl1_mmetabolite locus 1, pyridoxate (mouse)14127539975275399Mouse
10412185Hcs9_mhepatocarcinogenesis susceptibility 9 (mouse)Not determined163854690189303617Mouse
13824984Twq5_mtestis weight QTL 5 (mouse)13069992184732197Mouse
1357721Sle17_msystematic lupus erythematosus susceptibility 17 (mouse)Not determined139132808126445310Mouse
1302146Cocrb1_mcocaine related behavior 1 (mouse)Not determined170133533104139557Mouse
1357824Estoq4_membryo survival total QTL 4 (mouse)Not determined13476013873976915Mouse
14746998Mancz1_mmandible centroid size 1 (mouse)15794135191941351Mouse
1300746Skl1_mskeletal size (tail length) 1 (mouse)Not determined15799197791992080Mouse
1357488Splq3_mspleen weight QTL 3 (mouse)Not determined134760138150193871Mouse
10043965Obq24_mobesity QTL 24 (mouse)Not determined15089021684890216Mouse
1301430Cdcs2_mcytokine deficiency colitis susceptibility 2 (mouse)Not determined14889234582892485Mouse
1558717Ses1a_msalmonella enteritidis susceptibility 1a (mouse)Not determined15672692290727077Mouse
1357759W3q12_mweight 3 weeks QTL 12 (mouse)Not determined13476013873976915Mouse
1357753Kidq2_mkidney weight QTL 2 (mouse)Not determined134760138150193871Mouse
1301667Lxw5_mlupus BXSB x NZW 5 (mouse)Not determined15854919192549443Mouse
1558822Vas1_mautoimmune vasitis resistance 1 (mouse)Not determined14888900682889210Mouse
1301670Ssta1_msusceptibility to Salmonella typhimurium antigens 1 (mouse)Not determined14594675579946882Mouse
1357475w3q13_mweight 3 weeks QTL 13 (mouse)Not determined12310959173976915Mouse
1357741Nidd5k_mNidd5 on KK-A<y> (mouse)Not determined15597494889975057Mouse
1301162Skull1_mskull morphology 1 (mouse)Not determined15799197791992080Mouse
4142467Wbcq1_mwhite blood cell quantitative locus 1 (mouse)Not determined15626621490266360Mouse
1301166Thypr2_mthymocyte proliferative response 2 (mouse)Not determined14127312475273271Mouse
1301933Insq6_minsulin QTL 6 (mouse)Not determined15672692290727077Mouse
1357524W6q14_mweight 6 weeks QTL 14 (mouse)Not determined13476013873976915Mouse
1301714Vertcling_mvertical clinging (mouse)Not determined14293803176938167Mouse
4141305Tgq9_mtriglyceride QTL 9 (mouse)Not determined5142160585421605Mouse
1357651Lgq5_mlate growth QTL 5 (mouse)Not determined13476013873976915Mouse
1301211Bbaa11_mB.burgdorferi-associated arthritis 11 (mouse)Not determined14888900682889210Mouse
1301722Cia9_mcollagen induced arthritis QTL 9 (mouse)Not determined145783900189303617Mouse
1558855Eae30_mexperimental allergic encephalomyelitis susceptibility 30 (mouse)Not determined14541777372975057Mouse
1301954Lrnx11_mlearning-contextual 11 (mouse)Not determined13913280874516365Mouse
1357505Vtbt1_mvertebral trabecular bone trait 1 (mouse)Not determined15626621490266360Mouse
1357506W10q6_mweight 10 weeks QTL 6 (mouse)Not determined13476013873976915Mouse
1301444Alcw5_malcohol withdrawal 5 (mouse)Not determined15854919192549443Mouse
4141032Wbcc1_mwhite blood cell count 1 (mouse)Not determined4225966776259667Mouse
39128207Lwq16_mliver weight QTL 16 (mouse)13476013873976915Mouse
1558860W10q7_mweight 10 weeks QTL 7 (mouse)Not determined134760138150193871Mouse
14747009Manh49_mmandible shape 49 (mouse)15794135191941351Mouse
1301616Yaa2_mY-linked autoimmune acceleration 2 (mouse)Not determined14685469080854839Mouse
1301748Abbp1_mA/J and C57BL/6 blood pressure 1 (mouse)Not determined162946755120529678Mouse
4142291Aec2_mautoimmune exocrinopathy 2 (mouse)Not determined52457737182250592Mouse
4141393Mol2_mmodifier of LPS-response 2 (mouse)Not determined7162467978183144Mouse
1558905Gct7_mgranulosa cell tumorigenesis 7 (mouse)Not determined14734989481350013Mouse
27095918Ulnl1_mulna length 1, 5 week (mouse)167339159129727737Mouse
1302119Cia15_mcollagen induced arthritis 15 (mouse)Not determined16588900688496101Mouse
13513915Heal50_mwound healing/ regeneration 50 (mouse)17166888073403586Mouse
1300841Ssial1_msusceptibility to sialadenitis 1 (mouse)Not determined163920002153557562Mouse
1301225Sle7_msystematic lupus erythematosus susceptibility 7 (mouse)Not determined14685469080854839Mouse
1357679Egrm1_mearly growth rate, maternal effect 1 (mouse)Not determined15799197791992080Mouse

Markers in Region
Igfbp2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv37172,898,718 - 72,898,989UniSTSGRCm37
Celera173,420,330 - 73,420,601UniSTS
Cytogenetic Map1C3UniSTS
cM Map136.1UniSTS
cM Map136.1UniSTS
AI255832  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38172,852,233 - 72,852,375UniSTSGRCm38
MGSCv37172,898,807 - 72,898,949UniSTSGRCm37
Celera173,420,419 - 73,420,561UniSTS
Cytogenetic Map1C3UniSTS
cM Map136.1UniSTS
Whitehead/MRC_RH11001.99UniSTS
L05439  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38172,852,233 - 72,852,365UniSTSGRCm38
MGSCv37172,898,807 - 72,898,939UniSTSGRCm37
Celera173,420,419 - 73,420,551UniSTS
Cytogenetic Map1C3UniSTS
cM Map136.1UniSTS
Whitehead/MRC_RH11001.35UniSTS
Igfbp2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38172,852,144 - 72,852,415UniSTSGRCm38
MGSCv37172,898,718 - 72,898,989UniSTSGRCm37
Celera173,420,330 - 73,420,601UniSTS
Cytogenetic Map1C3UniSTS
Igfbp2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map1C3UniSTS
cM Map136.1UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000047328   ⟹   ENSMUSP00000046610
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl172,863,662 - 72,891,633 (+)Ensembl
GRCm38.p6 Ensembl172,824,503 - 72,852,474 (+)Ensembl
Ensembl Acc Id: ENSMUST00000120564   ⟹   ENSMUSP00000112706
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl172,864,481 - 72,891,626 (+)Ensembl
GRCm38.p6 Ensembl172,825,322 - 72,852,467 (+)Ensembl
Ensembl Acc Id: ENSMUST00000155703
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl172,887,858 - 72,891,307 (+)Ensembl
GRCm38.p6 Ensembl172,848,699 - 72,852,148 (+)Ensembl
RefSeq Acc Id: NM_001310659   ⟹   NP_001297588
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39172,863,650 - 72,891,633 (+)NCBI
GRCm38172,825,387 - 72,852,474 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001420245   ⟹   NP_001407174
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39172,865,738 - 72,891,633 (+)NCBI
RefSeq Acc Id: NM_008342   ⟹   NP_032368
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39172,863,650 - 72,891,633 (+)NCBI
GRCm38172,824,480 - 72,852,474 (+)ENTREZGENE
MGSCv37172,871,078 - 72,899,048 (+)RGD
Celera173,392,679 - 73,420,660 (+)RGD
cM Map1 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_030250357   ⟹   XP_030106217
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39172,864,255 - 72,891,633 (+)NCBI
GRCm38172,825,381 - 72,852,474 (+)NCBI
Sequence:
RefSeq Acc Id: NP_032368   ⟸   NM_008342
- Peptide Label: isoform 1 precursor
- UniProtKB: Q61722 (UniProtKB/Swiss-Prot),   Q91VK7 (UniProtKB/Swiss-Prot),   P47877 (UniProtKB/Swiss-Prot),   Q9D057 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001297588   ⟸   NM_001310659
- Peptide Label: isoform 2
- UniProtKB: D3YU40 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_030106217   ⟸   XM_030250357
- Peptide Label: isoform X1
- UniProtKB: D3YU40 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSMUSP00000046610   ⟸   ENSMUST00000047328
Ensembl Acc Id: ENSMUSP00000112706   ⟸   ENSMUST00000120564
RefSeq Acc Id: NP_001407174   ⟸   NM_001420245
- Peptide Label: isoform 2
- UniProtKB: D3YU40 (UniProtKB/TrEMBL)
Protein Domains
IGFBP N-terminal   Thyroglobulin type-1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P47877-F1-model_v2 AlphaFold P47877 1-305 view protein structure

Promoters
RGD ID:6874032
Promoter ID:EPDNEW_M467
Type:initiation region
Name:Igfbp2_1
Description:Mus musculus insulin-like growth factor binding protein 2 , transcriptvariant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38172,824,492 - 72,824,552EPDNEW
RGD ID:6817915
Promoter ID:MM_KWN:1128
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:ES_Cell,   Liver,   Lung,   MEF_B4
Transcripts:ENSMUST00000080287,   ENSMUST00000120564,   OTTMUST00000073338
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36172,870,821 - 72,871,892 (+)MPROMDB
RGD ID:6817918
Promoter ID:MM_KWN:1129
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver,   MEF_B6
Transcripts:OTTMUST00000073340
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36172,894,401 - 72,895,782 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:96437 AgrOrtholog
Ensembl Genes ENSMUSG00000039323 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000047328 ENTREZGENE
  ENSMUST00000047328.11 UniProtKB/Swiss-Prot
  ENSMUST00000120564 ENTREZGENE
Gene3D-CATH 4.10.40.20 UniProtKB/Swiss-Prot
  4.10.800.10 UniProtKB/Swiss-Prot
InterPro Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot
  IGFBP-2 UniProtKB/Swiss-Prot
  IGFBP-like UniProtKB/Swiss-Prot
  IGFBP_1-6_chordata UniProtKB/Swiss-Prot
  Insulin_GF-bd_Cys-rich_CS UniProtKB/Swiss-Prot
  Thyroglobulin_1 UniProtKB/Swiss-Prot
  Thyroglobulin_1_sf UniProtKB/Swiss-Prot
KEGG Report mmu:16008 UniProtKB/Swiss-Prot
MGD MGI:96437 ENTREZGENE
NCBI Gene 16008 ENTREZGENE
PANTHER INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN UniProtKB/Swiss-Prot
  INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN 2 UniProtKB/Swiss-Prot
Pfam IGFBP UniProtKB/Swiss-Prot
  Thyroglobulin_1 UniProtKB/Swiss-Prot
PhenoGen Igfbp2 PhenoGen
PRINTS IGFBPFAMILY UniProtKB/Swiss-Prot
  IGFBPFAMILY2 UniProtKB/Swiss-Prot
PROSITE IGFBP_N_1 UniProtKB/Swiss-Prot
  IGFBP_N_2 UniProtKB/Swiss-Prot
  THYROGLOBULIN_1_1 UniProtKB/Swiss-Prot
  THYROGLOBULIN_1_2 UniProtKB/Swiss-Prot
SMART SM00121 UniProtKB/Swiss-Prot
  SM00211 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF57184 UniProtKB/Swiss-Prot
  SSF57610 UniProtKB/Swiss-Prot
UniProt D3YU40 ENTREZGENE, UniProtKB/TrEMBL
  IBP2_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q61722 ENTREZGENE
  Q91VK7 ENTREZGENE
  Q9D057 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q61722 UniProtKB/Swiss-Prot
  Q91VK7 UniProtKB/Swiss-Prot