Igf2 (insulin-like growth factor 2) - Rat Genome Database

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Gene: Igf2 (insulin-like growth factor 2) Mus musculus
Analyze
Symbol: Igf2
Name: insulin-like growth factor 2
RGD ID: 10770
MGI Page MGI
Description: Enables protein kinase activator activity and signaling receptor binding activity. Involved in several processes, including cell surface receptor protein tyrosine kinase signaling pathway; embryonic placenta development; and positive regulation of developmental growth. Acts upstream of or within several processes, including exocrine pancreas development; positive regulation of transcription by RNA polymerase II; and striated muscle cell differentiation. Located in extracellular space. Is expressed in several structures, including alimentary system; brain; early conceptus; embryo mesenchyme; and sensory organ. Used to study type 1 diabetes mellitus 2. Human ortholog(s) of this gene implicated in Silver-Russell syndrome; choriocarcinoma; hepatocellular carcinoma; and rheumatoid arthritis. Orthologous to human IGF2 (insulin like growth factor 2).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: AL033362; Igf; Igf-; Igf-2; Igf-II; insulin-like growth factor II; M; M6; M6pr; Mpr; multiplication-stimulating polypeptide; Peg; Peg2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397142,204,505 - 142,220,566 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7142,204,503 - 142,220,553 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm387142,650,768 - 142,666,816 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7142,650,766 - 142,666,816 (-)Ensemblmm10GRCm38
MGSCv377149,836,673 - 149,846,940 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv367142,460,158 - 142,468,879 (-)NCBIMGSCv36mm8
Celera7142,407,105 - 142,417,364 (-)NCBICelera
Cytogenetic Map7F5NCBI
cM Map787.99NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
acquired immunodeficiency syndrome  (ISO)
adrenocortical carcinoma  (ISO)
alcohol use disorder  (ISO)
Alcoholic Liver Diseases  (ISO)
alcoholic neuropathy  (ISO)
Alzheimer's disease  (IDA,IEP,ISO)
anemia  (ISO)
Animal Mammary Neoplasms  (ISO)
atherosclerosis  (ISO)
autistic disorder  (ISO)
Beckwith-Wiedemann syndrome  (ISO)
bone development disease  (ISO)
Brain Hypoxia-Ischemia  (ISO)
brain infarction  (ISO)
Brain Injuries  (ISO)
breast cancer  (ISO)
choriocarcinoma  (ISO)
Chronic Hepatitis C  (ISO)
cognitive disorder  (ISO)
Colonic Neoplasms  (ISO)
colorectal cancer  (ISO)
Colorectal Neoplasms  (ISO)
congenital diaphragmatic hernia  (ISO)
congenital disorder of glycosylation Ia  (ISO)
delta beta-thalassemia  (ISO)
developmental and epileptic encephalopathy  (ISO)
Diabetic Nephropathies  (ISO)
Diaphragmatic Hernia  (ISO)
Embryo Loss  (ISO)
Ependymomas  (ISO)
Experimental Diabetes Mellitus  (IDA,IEP,ISO)
Experimental Liver Neoplasms  (ISO)
Experimental Radiation Injuries  (ISO)
Fetal Growth Retardation  (ISO)
gastrointestinal system disease  (ISO)
genetic disease  (ISO)
Growth Disorders  (ISO)
Hepatic Echinococcosis  (ISO)
hepatoblastoma  (ISO)
hepatocellular carcinoma  (ISO)
hypoglycemia  (ISO)
immunodeficiency 39  (ISO)
inflammatory bowel disease  (ISO)
Lewy body dementia  (ISO)
liver cirrhosis  (ISO)
Liver Neoplasms  (ISO)
Lung Injury  (ISO)
Memory Disorders  (ISO)
meningitis  (ISO)
Metabolic Syndrome  (ISO)
multiple sclerosis  (ISO)
multiple system atrophy  (ISO)
Neoplasm Metastasis  (IEP)
nephroblastoma  (ISO)
Nerve Degeneration  (ISO)
neuronal ceroid lipofuscinosis  (ISO)
obesity  (ISO)
osteoarthritis  (ISO)
osteoporosis  (ISO)
Parkinson's disease  (ISO)
placenta disease  (ISO)
polyhydramnios  (ISO)
Postmenopausal Osteoporosis  (ISO)
pre-malignant neoplasm  (ISO)
rhabdomyosarcoma  (ISO)
rheumatoid arthritis  (ISO)
Segawa Syndrome, Autosomal Recessive  (ISO)
Silver-Russell syndrome  (ISO)
Silver-Russell Syndrome 1  (ISO)
Silver-Russell Syndrome 3  (ISO)
Spontaneous Abortions  (ISO)
type 1 diabetes mellitus  (ISO)
type 1 diabetes mellitus 2  (IAGP)
type 2 diabetes mellitus  (IMP,ISO)
ulcerative colitis  (ISO)
ventricular septal defect  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(S)-nicotine  (ISO)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2-acetamidofluorene  (ISO)
2-ethoxyethanol  (ISO)
2-methoxyethanol  (ISO)
28-Homobrassinolide  (ISO)
3,4-methylenedioxymethamphetamine  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxyphenyl retinamide  (EXP)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (ISO)
acetylsalicylic acid  (ISO)
acrylamide  (EXP)
adenosine  (ISO)
aflatoxin B1  (ISO)
all-trans-4-oxoretinoic acid  (ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-naphthoflavone  (ISO)
aluminium sulfate (anhydrous)  (ISO)
aluminium trifluoride  (ISO)
amitrole  (ISO)
ammonium chloride  (ISO)
Ampullosporin  (ISO)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (EXP)
arsenous acid  (ISO)
Azoxymethane  (EXP)
benzimidazoles  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
benzylpenicillin  (ISO)
bexarotene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bortezomib  (ISO)
budesonide  (EXP)
buta-1,3-diene  (EXP)
butanal  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (ISO)
calciol  (EXP)
calcium atom  (EXP)
calcium(0)  (EXP)
capsaicin  (ISO)
carbon nanotube  (ISO)
carbonyl sulfide  (ISO)
carmustine  (ISO)
choline  (EXP,ISO)
chromium atom  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
citalopram  (ISO)
cobalt atom  (EXP)
cobalt dichloride  (ISO)
cocaine  (ISO)
corticosterone  (ISO)
cortisol  (ISO)
crocidolite asbestos  (ISO)
CU-O LINKAGE  (ISO)
Cuprizon  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
dantrolene  (ISO)
DDE  (ISO)
DDT  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (ISO)
dichloroacetic acid  (EXP)
dicrotophos  (ISO)
diethylstilbestrol  (EXP,ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
escitalopram  (ISO)
estrone  (ISO)
ethanol  (ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (ISO)
ethylparaben  (ISO)
fenvalerate  (EXP,ISO)
fluoxetine  (ISO)
folic acid  (EXP,ISO)
fonofos  (ISO)
fulvestrant  (ISO)
furan  (ISO)
genistein  (EXP)
gentamycin  (ISO)
glycidol  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
hexadecanoic acid  (ISO)
hydrogen peroxide  (EXP)
indometacin  (ISO)
iron dichloride  (ISO)
ketamine  (ISO)
L-methionine  (EXP)
lanthanum atom  (EXP)
lead diacetate  (EXP,ISO)
lead nitrate  (EXP)
lead(0)  (ISO)
lipopolysaccharide  (EXP,ISO)
LY294002  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
metformin  (ISO)
methimazole  (ISO)
monosodium L-glutamate  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel subsulfide  (ISO)
nicotine  (ISO)
nifedipine  (ISO)
nitrofen  (ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
oxaliplatin  (ISO)
ozone  (EXP)
panobinostat  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
parathion  (ISO)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (ISO)
phenylarsine oxide  (ISO)
phenylmercury acetate  (ISO)
phenytoin  (EXP)
phthalic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
propanal  (ISO)
propiconazole  (EXP)
quercetin  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
SB 203580  (ISO)
serpentine asbestos  (ISO)
sertraline  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (EXP,ISO)
sulfadimethoxine  (ISO)
sunitinib  (ISO)
tamoxifen  (EXP,ISO)
Tanshinone I  (ISO)
temozolomide  (ISO)
terbufos  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
tetramethrin  (EXP)
thioacetamide  (ISO)
tipifarnib  (ISO)
titanium dioxide  (EXP)
topotecan  (ISO)
trichloroacetic acid  (EXP)
trichloroethene  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (EXP)
triphenyl phosphate  (EXP)
triptonide  (EXP)
urethane  (EXP)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)
vinyl carbamate  (EXP)
vorinostat  (ISO)
wortmannin  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ morphogenesis  (IMP)
cellular response to mechanical stimulus  (ISO)
embryonic placenta development  (IMP)
embryonic placenta morphogenesis  (IMP)
exocrine pancreas development  (IMP)
female pregnancy  (ISO)
glucose metabolic process  (IEA)
in utero embryonic development  (IMP)
insulin receptor signaling pathway  (IMP)
insulin-like growth factor receptor signaling pathway  (IDA,IGI,ISO)
memory  (ISO)
negative regulation of muscle cell differentiation  (IMP)
negative regulation of natural killer cell mediated cytotoxicity  (ISO)
negative regulation of transcription by RNA polymerase II  (IMP)
ossification  (IEA)
osteoblast differentiation  (IEP)
positive regulation of activated T cell proliferation  (IBA,IEA,ISO)
positive regulation of angiogenesis  (ISO)
positive regulation of blood vessel endothelial cell migration  (ISO)
positive regulation of cell division  (IEA)
positive regulation of cell population proliferation  (IEA,ISO,ISS)
positive regulation of glycogen biosynthetic process  (IMP)
positive regulation of insulin receptor signaling pathway  (IBA,IEA,ISO)
positive regulation of MAPK cascade  (IBA,IEA,ISO)
positive regulation of mitotic nuclear division  (IEA,ISO)
positive regulation of multicellular organism growth  (IMP)
positive regulation of organ growth  (IMP)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA,IMP,ISO)
positive regulation of skeletal muscle tissue growth  (IMP)
positive regulation of steroid hormone biosynthetic process  (ISO)
positive regulation of transcription by RNA polymerase II  (IBA,IGI)
positive regulation of vascular endothelial cell proliferation  (IBA,ISO)
regulation of muscle cell differentiation  (IBA,IMP)
response to 2,3,7,8-tetrachlorodibenzodioxine  (ISO)
response to estradiol  (ISO)
response to ethanol  (ISO)
response to nicotine  (ISO)
response to nutrient levels  (ISO)
response to xenobiotic stimulus  (ISO)
spongiotrophoblast cell proliferation  (IMP)
striated muscle cell differentiation  (IGI)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal body size  (IAGP)
abnormal bone marrow cavity morphology  (IAGP)
abnormal bone trabecula morphology  (IAGP)
abnormal cartilage development  (IAGP)
abnormal circulating hormone level  (IAGP)
abnormal compact bone lamellar structure  (IAGP)
abnormal epidermal layer morphology  (IAGP)
abnormal gait  (IAGP)
abnormal heart morphology  (IAGP)
abnormal heart septum morphology  (IAGP)
abnormal heart ventricle morphology  (IAGP)
abnormal imprinting  (IAGP)
abnormal lens development  (IAGP)
abnormal lens epithelium morphology  (IAGP)
abnormal lens morphology  (IAGP)
abnormal lumbar vertebrae morphology  (IAGP)
abnormal myocardium layer morphology  (IAGP)
abnormal nervous system morphology  (IAGP)
abnormal osteoblast differentiation  (IAGP)
abnormal osteoclast differentiation  (IAGP)
abnormal placental transport  (IAGP)
abnormal postnatal growth  (IAGP)
abnormal prenatal growth/weight/body size  (IAGP)
abnormal skeleton development  (IAGP)
abnormal skeleton morphology  (IAGP)
abnormal sternum morphology  (IAGP)
abnormal tibia morphology  (IAGP)
abnormal xiphoid process morphology  (IAGP)
adrenal gland cyst  (IAGP)
cleft palate  (IAGP)
decreased birth body size  (IAGP)
decreased birth weight  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased bone mineral density  (IAGP)
decreased fetal weight  (IAGP)
decreased kidney weight  (IAGP)
decreased osteoblast cell number  (IAGP)
decreased placenta weight  (IAGP)
delayed bone ossification  (IAGP)
delayed eyelid fusion  (IAGP)
edema  (IAGP)
embryonic growth retardation  (IAGP)
enlarged aortic valve  (IAGP)
enlarged pulmonary valve  (IAGP)
fetal growth retardation  (IAGP)
increased birth weight  (IAGP)
increased compact bone thickness  (IAGP)
increased fetal cardiomyocyte proliferation  (IAGP)
increased fetal weight  (IAGP)
increased heart weight  (IAGP)
increased hepatocyte proliferation  (IAGP)
increased liver weight  (IAGP)
increased placenta weight  (IAGP)
increased spongiotrophoblast size  (IAGP)
lethality throughout fetal growth and development, complete penetrance  (IAGP)
lethality throughout fetal growth and development, incomplete penetrance  (IAGP)
maternal imprinting  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
omphalocele  (IAGP)
pericardial edema  (IAGP)
polydactyly  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
prenatal growth retardation  (IEA)
respiratory failure  (IAGP)
small placenta  (IAGP)
split sternum  (IAGP)
thick aortic valve  (IAGP)
thick pulmonary valve  (IAGP)
thin epidermis stratum spinosum  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Oleic acid ameliorates amyloidosis in cellular and mouse models of Alzheimer's disease. Amtul Z, etal., Brain Pathol. 2011 May;21(3):321-9. doi: 10.1111/j.1750-3639.2010.00449.x. Epub 2010 Nov 11.
2. Uptake of circulating insulin-like growth factor-I into the cerebrospinal fluid of normal and diabetic rats and normalization of IGF-II mRNA content in diabetic rat brain. Armstrong CS, etal., J Neurosci Res. 2000 Mar 1;59(5):649-60.
3. [Changes of serum and cerebrospinal fluid insulin-like growth factor-II levels in neonates with hypoxic-ischemic encephalopathy]. Bai B, etal., Zhongguo Dang Dai Er Ke Za Zhi. 2006 Jun;8(3):187-90.
4. Gastrointestinal inflammation and the circulating IGF system in humans. Baricevic I, etal., Horm Metab Res. 2006 Jan;38(1):22-7.
5. Insulin-like growth factor II is induced during wound repair following hypoxic-ischemic injury in the developing rat brain. Beilharz EJ, etal., Brain Res Mol Brain Res. 1995 Mar;29(1):81-91.
6. In utero radiation-induced changes in growth factor levels in the developing rat brain. Benekou A, etal., Int J Radiat Biol. 2001 Jan;77(1):83-93.
7. Defective IGF2 and IGF1R protein production in embryonic pancreas precedes beta cell mass anomaly in the Goto-Kakizaki rat model of type 2 diabetes. Calderari S, etal., Diabetologia. 2007 Jul;50(7):1463-71. Epub 2007 May 3.
8. Subcutaneous administration of insulin-like growth factor (IGF)-II/IGF binding protein-2 complex stimulates bone formation and prevents loss of bone mineral density in a rat model of disuse osteoporosis. Conover CA, etal., Growth Horm IGF Res. 2002 Jun;12(3):178-83.
9. The insulin-like growth factor axis in children with inflammatory bowel disease. Corkins MR, etal., J Pediatr Gastroenterol Nutr. 2003 Feb;36(2):228-34.
10. Various components of the insulin-like growth factor system in tumor tissue, cerebrospinal fluid and peripheral blood of pediatric medulloblastoma and ependymoma patients. de Bont JM, etal., Int J Cancer. 2008 Aug 1;123(3):594-600.
11. Insulin resistance in experimental alcohol-induced liver disease. de la Monte SM, etal., J Gastroenterol Hepatol. 2008 Aug;23(8 Pt 2):e477-86. Epub 2008 May 26.
12. Transgenic mice overexpressing insulin-like growth factor-II in beta cells develop type 2 diabetes. Devedjian JC, etal., J Clin Invest. 2000 Mar;105(6):731-40.
13. IGF-II regulates metastatic properties of choriocarcinoma cells through the activation of the insulin receptor. Diaz LE, etal., Mol Hum Reprod. 2007 Aug;13(8):567-76. Epub 2007 Jun 6.
14. Roles of insulin-like growth factor (IGF) binding proteins in regulating IGF actions. Duan C and Xu Q, Gen Comp Endocrinol. 2005 May 15;142(1-2):44-52. Epub 2005 Feb 5.
15. The insulin-like growth factor system and markers of inflammation in adult patients with inflammatory bowel disease. Eivindson M, etal., Horm Res. 2005;64(1):9-15. Epub 2005 Jul 25.
16. Elevated free IGF2 levels in localized, early-stage breast cancer in women. Espelund U, etal., Eur J Endocrinol. 2008 Nov;159(5):595-601. Epub 2008 Aug 21.
17. Comparative effects of probiotics, prebiotics, and synbiotics on growth factors in the large bowel in a rat model of formula-induced bowel inflammation. Fordjour L, etal., J Pediatr Gastroenterol Nutr. 2010 Oct;51(4):507-13.
18. Positive associations between single nucleotide polymorphisms in the IGF2 gene region and body mass index in adult males. Gaunt TR, etal., Hum Mol Genet. 2001 Jul 1;10(14):1491-501.
19. NMDA receptor mediated changes in IGF-II gene expression in the rat brain after injury and the possible role of nitric oxide. Giannakopoulou M, etal., Neuropathol Appl Neurobiol. 2000 Dec;26(6):513-21.
20. A simple in silico strategy identifies candidate biomarkers for the diagnosis of liver fibrosis in morbidly obese subjects. Giraudi PJ, etal., Liver Int. 2018 Jan;38(1):155-163. doi: 10.1111/liv.13505. Epub 2017 Jul 21.
21. Insulin-like growth factors and binding proteins in multiple sclerosis plaques. Gveric D, etal., Neuropathol Appl Neurobiol. 1999 Jun;25(3):215-25.
22. Tissue-specific regulation of insulin-like growth factors and insulin-like growth factor binding proteins in male diabetic rats in vivo and in vitro. Han HJ, etal., Clin Exp Pharmacol Physiol. 2006 Dec;33(12):1172-9.
23. The insulin-like growth factor system in human immunodeficiency virus infection: relations to immunological parameters, disease progression, and antiretroviral therapy. Helle SI, etal., J Clin Endocrinol Metab. 2001 Jan;86(1):227-33.
24. Changes in cerebrospinal fluid and blood plasma levels of IGF-II and its binding proteins in Alzheimer's disease: an observational study. Hertze J, etal., BMC Neurol. 2014 Apr 1;14:64. doi: 10.1186/1471-2377-14-64.
25. Insulin-Like growth factor-II (IGF-II) prevents proinflammatory cytokine-induced apoptosis and significantly improves islet survival after transplantation. Hughes A, etal., Transplantation. 2013 Mar 15;95(5):671-8. doi: 10.1097/TP.0b013e31827fa453.
26. Gene Expression Profiling Distinguishes Between Spontaneous and Radiation-induced Rat Mammary Carcinomas. Imaoka T, etal., J Radiat Res (Tokyo). 2008 Apr 16;.
27. Abnormal Igf2 gene in Prague hereditary hypertriglyceridemic rats: its relation to blood pressure and plasma lipids. Kadlecova M, etal., Mol Cell Biochem. 2008 Jul;314(1-2):37-43. Epub 2008 Apr 17.
28. Thymic expression of insulin-related genes in an animal model of autoimmune type 1 diabetes. Kecha-Kamoun O, etal., Diabetes Metab Res Rev. 2001 Mar-Apr;17(2):146-52.
29. IGF2 polymorphisms are associated with hepatitis B virus clearance and hepatocellular carcinoma. Kim YJ, etal., Biochem Biophys Res Commun. 2006 Jul 21;346(1):38-44. doi: 10.1016/j.bbrc.2006.05.080. Epub 2006 May 24.
30. Mapping of glutathione transferase (GST) genes in the rat. Klinga-Levan K, etal., Hereditas 1993;119(3):285-96.
31. Prenatal administration of retinoic acid increases the trophoblastic insulin-like growth factor 2 protein expression in the nitrofen model of congenital diaphragmatic hernia. Kutasy B, etal., Pediatr Surg Int. 2014 Feb;30(2):137-42. doi: 10.1007/s00383-013-3449-7.
32. Intracerebral streptozotocin model of type 3 diabetes: relevance to sporadic Alzheimer's disease. Lester-Coll N, etal., J Alzheimers Dis. 2006 Mar;9(1):13-33.
33. Effect of two selenium sources on hepatocarcinogenesis and several angiogenic cytokines in diethylnitrosamine-induced hepatocarcinoma rats. Liu JG, etal., J Trace Elem Med Biol. 2012 Oct;26(4):255-61. doi: 10.1016/j.jtemb.2012.02.001. Epub 2012 Mar 16.
34. Teriparatide increases bone formation in modeling and remodeling osteons and enhances IGF-II immunoreactivity in postmenopausal women with osteoporosis. Ma YL, etal., J Bone Miner Res. 2006 Jun;21(6):855-64.
35. Loss of imprinting of IGF2 characterises high IGF2 mRNA-expressing type of fibroblast-like synoviocytes in rheumatoid arthritis. Martin-Trujillo A, etal., Ann Rheum Dis. 2010 Jun;69(6):1239-42. Epub 2009 Jun 24.
36. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
37. MGDs mouse GO annotations MGD data from the GO Consortium
38. MGD IEA MGD IEA
39. IGF system in children with congenital disorders of glycosylation. Miller BS, etal., Clin Endocrinol (Oxf). 2009 Jun;70(6):892-7. doi: 10.1111/j.1365-2265.2009.03531.x. Epub 2009 Jan 22.
40. Changes in the antioxidant defense and hepatic drug metabolizing enzyme and isoenzyme levels, 8-hydroxydeoxyguanosine formation and expressions of c-raf.1 and insulin-like growth factor II genes during the stages of development of hepatocellular carcinoma in rats. Mukherjee B, etal., Eur J Cancer Prev. 2007 Aug;16(4):363-71.
41. Concentrations of insulin-like growth factor (IGF)-binding protein-3 (IGFBP-3), IGF, and IGFBP-3 protease activity in cerebrospinal fluid of children with leukemia, central nervous system tumor, or meningitis. Muller HL, etal., J Clin Endocrinol Metab. 1993 Nov;77(5):1113-9.
42. Insulin-like growth factors and their binding proteins in the circulation of patients with echinococcosis, trichinellosis and toxoplasmosis. Nedic O, etal., Clin Chim Acta. 2003 Sep;335(1-2):83-8.
43. Changes in systemic levels of insulin-like growth factors and their binding proteins in patients with rheumatoid arthritis. Neidel J Clin Exp Rheumatol. 2001 Jan-Feb;19(1):81-4.
44. Experimental alcohol-related peripheral neuropathy: role of insulin/IGF resistance. Nguyen VA, etal., Nutrients. 2012 Aug;4(8):1042-57. Epub 2012 Aug 17.
45. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
46. Effect of tamoxifen treatment on global and insulin-like growth factor 2-H19 locus-specific DNA methylation in rat spermatozoa and its association with embryo loss. Pathak S, etal., Fertil Steril. 2009 May;91(5 Suppl):2253-63. Epub 2008 Sep 7.
47. Early alterations in energy metabolism in the hippocampus of APPswe/PS1dE9 mouse model of Alzheimer's disease. Pedros I, etal., Biochim Biophys Acta. 2014 Sep;1842(9):1556-66. doi: 10.1016/j.bbadis.2014.05.025. Epub 2014 Jun 2.
48. Multiple system atrophy is associated with changes in peripheral insulin-like growth factor system. Pellecchia MT, etal., Mov Disord. 2010 Nov 15;25(15):2621-6.
49. Changes in IGF-I and -II, IGF binding protein, and IGF receptor transcript abundance after uterine artery ligation. Price WA, etal., Pediatr Res. 1992 Sep;32(3):291-5. doi: 10.1203/00006450-199209000-00009.
50. Mouse MP Annotation Import Pipeline RGD automated import pipeline
51. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
52. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
53. Collagen induced arthritis increases secondary metastasis in MMTV-PyV MT mouse model of mammary cancer. Roy LD, etal., BMC Cancer. 2011 Aug 22;11:365.
54. Alterations in methylation and expression levels of imprinted genes H19 and Igf2 in the fetuses of diabetic mice. Shao WJ, etal., Comp Med. 2008 Aug;58(4):341-6.
55. Alcohol-induced cognitive deficits are associated with decreased circulating levels of the neurotrophin BDNF in humans and rats. Silva-Peña D, etal., Addict Biol. 2019 Sep;24(5):1019-1033. doi: 10.1111/adb.12668. Epub 2018 Sep 12.
56. Regulation of H19 and its encoded microRNA-675 in osteoarthritis and under anabolic and catabolic in vitro conditions. Steck E, etal., J Mol Med (Berl). 2012 Oct;90(10):1185-95. doi: 10.1007/s00109-012-0895-y. Epub 2012 Apr 21.
57. Brain insulin-like growth factor and neurotrophin resistance in Parkinson's disease and dementia with Lewy bodies: potential role of manganese neurotoxicity. Tong M, etal., J Alzheimers Dis. 2009;16(3):585-99.
58. IGF-II and MMP9 as surgical repair indicators of ventricular septal defects. Tsai CY, etal., Clin Chim Acta. 2011 Apr 11;412(9-10):761-5. doi: 10.1016/j.cca.2011.01.005. Epub 2011 Jan 14.
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60. Acetyl-L-carnitine rescues scopolamine-induced memory deficits by restoring insulin-like growth factor II via decreasing p53 oxidation. Wang X, etal., Neuropharmacology. 2014 Jan;76 Pt A:80-7. doi: 10.1016/j.neuropharm.2013.08.022. Epub 2013 Sep 4.
61. Brain insulin-like growth factor-II mRNA content is reduced in insulin-dependent and non-insulin-dependent diabetes mellitus. Wuarin L, etal., J Neurochem. 1996 Aug;67(2):742-51.
62. Immunolocalization of insulin-like growth factors and their receptors in the diabetic mouse oviduct and uterine tissues during the preimplantation period. Zakaria R, etal., Acta Histochem. 2009;111(1):52-60. Epub 2008 Aug 3.
63. Insulin-like growth factor (IGF) gene expression is reduced in neural tissues and liver from rats with non-insulin-dependent diabetes mellitus, and IGF treatment ameliorates diabetic neuropathy. Zhuang HX, etal., J Pharmacol Exp Ther. 1997 Oct;283(1):366-74.
Additional References at PubMed
PMID:1284245   PMID:1303252   PMID:1314574   PMID:1317321   PMID:1374351   PMID:1383088   PMID:1457378   PMID:1497882   PMID:1507224   PMID:1628813   PMID:1701096   PMID:1702294  
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Genomics

Comparative Map Data
Igf2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397142,204,505 - 142,220,566 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7142,204,503 - 142,220,553 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm387142,650,768 - 142,666,816 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7142,650,766 - 142,666,816 (-)Ensemblmm10GRCm38
MGSCv377149,836,673 - 149,846,940 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv367142,460,158 - 142,468,879 (-)NCBIMGSCv36mm8
Celera7142,407,105 - 142,417,364 (-)NCBICelera
Cytogenetic Map7F5NCBI
cM Map787.99NCBI
IGF2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38112,129,117 - 2,149,566 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl112,129,112 - 2,158,391 (-)Ensemblhg38GRCh38
GRCh37112,150,347 - 2,170,796 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36112,106,923 - 2,127,409 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34112,110,531 - 2,116,578NCBI
Celera112,186,838 - 2,207,338 (-)NCBICelera
Cytogenetic Map11p15.5NCBI
HuRef111,940,869 - 1,961,095 (-)NCBIHuRef
CHM1_1112,148,973 - 2,169,786 (-)NCBICHM1_1
T2T-CHM13v2.0112,216,758 - 2,237,216 (-)NCBIT2T-CHM13v2.0
Igf2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81207,243,873 - 207,261,263 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1207,243,873 - 207,260,667 (-)EnsemblGRCr8
mRatBN7.21197,814,409 - 197,831,802 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1197,814,410 - 197,823,018 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1206,187,237 - 206,197,377 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01213,273,145 - 213,283,290 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01205,947,308 - 205,957,453 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01215,828,102 - 215,839,081 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1215,828,102 - 215,846,911 (-)Ensemblrn6Rnor6.0
Rnor_5.01222,722,921 - 222,733,868 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41202,906,624 - 202,915,231 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1195,432,460 - 195,442,561 (-)NCBICelera
RGSC_v3.11203,094,689 - 203,103,297 (-)NCBI
Cytogenetic Map1q41NCBI
Igf2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542213,880,471 - 13,888,566 (-)Ensembl
ChiLan1.0NW_00495542213,880,525 - 13,907,963 (-)NCBIChiLan1.0ChiLan1.0
IGF2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v294,555,470 - 4,584,748 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1113,767,218 - 3,777,154 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0112,170,190 - 2,199,442 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1112,202,764 - 2,228,890 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl112,202,743 - 2,228,890 (-)EnsemblpanPan2panpan1.1
IGF2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11846,294,036 - 46,311,982 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1846,294,019 - 46,311,982 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1844,906,773 - 44,921,790 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01846,973,499 - 46,991,455 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1846,973,482 - 47,002,253 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11846,425,198 - 46,440,216 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01846,005,530 - 46,020,544 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01846,751,952 - 46,766,988 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Igf2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049471,719,158 - 1,727,419 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936816972,282 - 979,167 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936816972,902 - 981,232 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IGF2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.121,469,183 - 1,496,417 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Pig Cytomap2pNCBI
IGF2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111,937,414 - 1,951,238 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11,936,830 - 1,945,388 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603899,135,565 - 99,144,253 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Igf2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476714,969,866 - 14,979,026 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462476714,969,977 - 14,997,577 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Igf2
669 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:6149
Count of miRNA genes:761
Interacting mature miRNAs:1048
Transcripts:ENSMUST00000000033, ENSMUST00000097936, ENSMUST00000105935, ENSMUST00000105936, ENSMUST00000121128, ENSMUST00000143666, ENSMUST00000145896, ENSMUST00000163148, ENSMUST00000178921
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27226751Femd5_mfemur midshaft diameter 5, 10 week (mouse)753249748143153737Mouse
27095933Ulnl3_mulna length 3, 5 week (mouse)773149748143153737Mouse
11059562Lmr21b_mleishmaniasis resistance 21b (mouse)7110967235144967336Mouse
1302032Alcp12_malcohol preference locus 12 (mouse)Not determined7111166122144995196Mouse
1301590Pbwg3_mpostnatal body weight growth 3 (mouse)Not determined7127311241144995196Mouse
1300566Sluc8_msusceptibility to lung cancer 8 (mouse)Not determined7127398151144995196Mouse
14700684Civq1_mcerebral infarct volume QTL 1 (mouse)7109707335143707335Mouse
1300670Sluc19_msusceptibility to lung cancer 19 (mouse)Not determined7111166122144995196Mouse
14746988Manh63_mmandible shape 63 (mouse)7127735437144995196Mouse
14700687Civq5_mcerebral infarct volume QTL 5 (mouse)7109707335143707335Mouse
14700688Civq6_mcerebral infarct volume QTL 6 (mouse)7109707335143707335Mouse
12792978Fbmd3_mfemoral bone mineral density 3, females only (mouse)77050288142367832Mouse
4142444Femwf5_mfemur work to failure 5 (mouse)Not determined112552248144995196Mouse
1300677Bmd9_mbone mineral density 9 (mouse)Not determined7116634089144995196Mouse
1300747Skts2_mskin tumor susceptibility 2 (mouse)Not determined7112922733144995196Mouse
1301898Alcp14_malcohol preference locus 14 (mouse)Not determined7111166122144995196Mouse
1357711Adbg1_madult body growth 1 (mouse)Not determined7118693381144398314Mouse
10402499Lmr21_mleishmaniasis resistance 21 (mouse)Not determined7110967235144967336Mouse
1301773Stheal7_msoft tissue heal 7 (mouse)Not determined7119132573144995196Mouse

Markers in Region
AW742446  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387142,651,209 - 142,651,458UniSTSGRCm38
MGSCv377149,837,114 - 149,837,363UniSTSGRCm37
Celera7142,407,546 - 142,407,795UniSTS
Cytogenetic Map7F5UniSTS
cM Map769.09UniSTS
Whitehead/MRC_RH71441.25UniSTS
D7Mit46  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387142,652,913 - 142,653,095UniSTSGRCm38
MGSCv377149,838,818 - 149,839,000UniSTSGRCm37
Celera7142,409,249 - 142,409,431UniSTS
Cytogenetic Map7F5UniSTS
cM Map769.0UniSTS
Whitehead Genetic764.5UniSTS
PMC309645P4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387142,655,388 - 142,655,706UniSTSGRCm38
MGSCv377149,841,293 - 149,841,611UniSTSGRCm37
Celera7142,411,724 - 142,412,042UniSTS
Cytogenetic Map7F5UniSTS
cM Map769.09UniSTS
PMC309645P5  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387142,653,740 - 142,654,078UniSTSGRCm38
MGSCv377149,839,645 - 149,839,983UniSTSGRCm37
Celera7142,410,076 - 142,410,414UniSTS
Cytogenetic Map7F5UniSTS
cM Map769.09UniSTS
PMC309645P6  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387142,650,335 - 142,650,610UniSTSGRCm38
MGSCv377149,836,240 - 149,836,515UniSTSGRCm37
Celera7142,406,672 - 142,406,947UniSTS
Cytogenetic Map7F5UniSTS
cM Map769.09UniSTS
PMC316622P2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387142,653,207 - 142,653,783UniSTSGRCm38
MGSCv377149,839,112 - 149,839,688UniSTSGRCm37
Celera7142,409,543 - 142,410,119UniSTS
Cytogenetic Map7F5UniSTS
cM Map769.09UniSTS
Igf2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv377149,837,071 - 149,837,622UniSTSGRCm37
MGSCv377149,840,328 - 149,841,666UniSTSGRCm37
MGSCv377149,839,018 - 149,839,239UniSTSGRCm37
MGSCv377149,839,654 - 149,840,282UniSTSGRCm37
MGSCv377149,841,599 - 149,841,795UniSTSGRCm37
MGSCv377149,836,693 - 149,836,864UniSTSGRCm37
MGSCv377149,839,654 - 149,839,811UniSTSGRCm37
MGSCv377149,841,573 - 149,841,657UniSTSGRCm37
MGSCv377149,839,737 - 149,840,313UniSTSGRCm37
MGSCv377149,839,471 - 149,840,234UniSTSGRCm37
Celera7142,410,759 - 142,412,097UniSTS
Celera7142,407,503 - 142,408,054UniSTS
Celera7142,409,449 - 142,409,670UniSTS
Celera7142,410,085 - 142,410,242UniSTS
Celera7142,409,902 - 142,410,665UniSTS
Celera7142,410,168 - 142,410,744UniSTS
Celera7142,412,004 - 142,412,088UniSTS
Celera7142,412,030 - 142,412,226UniSTS
Celera7142,407,125 - 142,407,296UniSTS
Celera7142,410,085 - 142,410,713UniSTS
Cytogenetic Map7F5UniSTS
cM Map769.09UniSTS
ECD21742  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387142,658,403 - 142,658,633UniSTSGRCm38
MGSCv377149,844,308 - 149,844,538UniSTSGRCm37
Celera7142,414,739 - 142,414,969UniSTS
Cytogenetic Map7F5UniSTS
cM Map769.09UniSTS
cM Map769.09UniSTS
PMC151856P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387142,654,014 - 142,654,376UniSTSGRCm38
MGSCv377149,839,919 - 149,840,281UniSTSGRCm37
Celera7142,410,350 - 142,410,712UniSTS
Cytogenetic Map7F5UniSTS
cM Map769.09UniSTS
Igf2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7F5UniSTS
Igf2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387142,653,259 - 142,653,840UniSTSGRCm38
Celera7142,409,595 - 142,410,176UniSTS
Cytogenetic Map7F5UniSTS
Igf2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387142,654,033 - 142,655,709UniSTSGRCm38
Celera7142,410,369 - 142,412,045UniSTS
Cytogenetic Map7F5UniSTS
Igf2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387142,654,425 - 142,655,733UniSTSGRCm38
Celera7142,410,761 - 142,412,069UniSTS
Cytogenetic Map7F5UniSTS
Igf2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7F5UniSTS
Igf2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387142,655,668 - 142,655,752UniSTSGRCm38
MGSCv377149,841,573 - 149,841,657UniSTSGRCm37
Celera7142,412,004 - 142,412,088UniSTS
Cytogenetic Map7F5UniSTS
Igf2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7F5UniSTS
Igf2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7F5UniSTS
Igf2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7F5UniSTS
Igf2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7F5UniSTS
cM Map769.09UniSTS
Igf2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387142,653,832 - 142,654,408UniSTSGRCm38
MGSCv377149,839,737 - 149,840,313UniSTSGRCm37
Celera7142,410,168 - 142,410,744UniSTS
Cytogenetic Map7F5UniSTS
cM Map769.09UniSTS
Igf2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387142,653,749 - 142,653,906UniSTSGRCm38
MGSCv377149,839,654 - 149,839,811UniSTSGRCm37
Celera7142,410,085 - 142,410,242UniSTS
Cytogenetic Map7F5UniSTS
cM Map769.09UniSTS
Igf2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7F5UniSTS
cM Map769.09UniSTS
Igf2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7F5UniSTS
cM Map769.09UniSTS
Igf2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7F5UniSTS
cM Map769.09UniSTS
Igf2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387142,653,749 - 142,654,377UniSTSGRCm38
MGSCv377149,839,654 - 149,840,282UniSTSGRCm37
Celera7142,410,085 - 142,410,713UniSTS
Cytogenetic Map7F5UniSTS
cM Map769.09UniSTS
Igf2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387142,651,166 - 142,651,717UniSTSGRCm38
MGSCv377149,837,071 - 149,837,622UniSTSGRCm37
Celera7142,407,503 - 142,408,054UniSTS
Cytogenetic Map7F5UniSTS
Igf2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387142,650,788 - 142,650,959UniSTSGRCm38
MGSCv377149,836,693 - 149,836,864UniSTSGRCm37
Celera7142,407,125 - 142,407,296UniSTS
Cytogenetic Map7F5UniSTS
Igf2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7F5UniSTS
cM Map769.09UniSTS
Igf2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387142,653,566 - 142,654,329UniSTSGRCm38
MGSCv377149,839,471 - 149,840,234UniSTSGRCm37
Celera7142,409,902 - 142,410,665UniSTS
Cytogenetic Map7F5UniSTS
cM Map769.09UniSTS
Igf2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387142,655,694 - 142,655,890UniSTSGRCm38
MGSCv377149,841,599 - 149,841,795UniSTSGRCm37
Celera7142,412,030 - 142,412,226UniSTS
Cytogenetic Map7F5UniSTS
cM Map769.09UniSTS
Igf2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387142,653,113 - 142,653,334UniSTSGRCm38
MGSCv377149,839,018 - 149,839,239UniSTSGRCm37
Celera7142,409,449 - 142,409,670UniSTS
Cytogenetic Map7F5UniSTS
Igf2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387142,654,423 - 142,655,761UniSTSGRCm38
MGSCv377149,840,328 - 149,841,666UniSTSGRCm37
Celera7142,410,759 - 142,412,097UniSTS
Cytogenetic Map7F5UniSTS
Igf2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7F5UniSTS
Igf2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7F5UniSTS
Igf2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7F5UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001122736 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001122737 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001315488 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001315489 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_010514 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006508487 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030242159 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036152697 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC013548 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH001929 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI322387 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK146531 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB840527 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC053489 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC058615 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CF742200 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466531 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CN460564 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CN527329 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CN666734 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF437373 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M14951 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M24633 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M36333 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M36334 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U71085 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X71918 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X71919 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X71920 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X71921 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X71922 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000000033   ⟹   ENSMUSP00000000033
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7142,204,503 - 142,211,233 (-)Ensembl
GRCm38.p6 Ensembl7142,650,766 - 142,657,496 (-)Ensembl
Ensembl Acc Id: ENSMUST00000097936   ⟹   ENSMUSP00000095549
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7142,204,506 - 142,211,203 (-)Ensembl
GRCm38.p6 Ensembl7142,650,769 - 142,657,466 (-)Ensembl
Ensembl Acc Id: ENSMUST00000105935   ⟹   ENSMUSP00000101555
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7142,207,493 - 142,220,553 (-)Ensembl
GRCm38.p6 Ensembl7142,653,756 - 142,666,816 (-)Ensembl
Ensembl Acc Id: ENSMUST00000105936   ⟹   ENSMUSP00000101556
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7142,204,506 - 142,215,042 (-)Ensembl
GRCm38.p6 Ensembl7142,650,769 - 142,661,305 (-)Ensembl
Ensembl Acc Id: ENSMUST00000121128   ⟹   ENSMUSP00000114076
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7142,204,506 - 142,213,226 (-)Ensembl
GRCm38.p6 Ensembl7142,650,769 - 142,659,489 (-)Ensembl
Ensembl Acc Id: ENSMUST00000143666
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7142,209,179 - 142,214,942 (-)Ensembl
GRCm38.p6 Ensembl7142,655,442 - 142,661,205 (-)Ensembl
Ensembl Acc Id: ENSMUST00000145896   ⟹   ENSMUSP00000122653
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7142,207,786 - 142,215,607 (-)Ensembl
GRCm38.p6 Ensembl7142,654,049 - 142,661,870 (-)Ensembl
Ensembl Acc Id: ENSMUST00000163148
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7142,204,580 - 142,206,767 (-)Ensembl
GRCm38.p6 Ensembl7142,650,843 - 142,653,030 (-)Ensembl
Ensembl Acc Id: ENSMUST00000178921   ⟹   ENSMUSP00000136786
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7142,208,089 - 142,209,755 (-)Ensembl
GRCm38.p6 Ensembl7142,654,352 - 142,656,018 (-)Ensembl
RefSeq Acc Id: NM_001122736   ⟹   NP_001116208
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397142,204,505 - 142,215,008 (-)NCBI
GRCm387142,650,768 - 142,661,271 (-)NCBI
MGSCv377149,836,673 - 149,846,940 (-)RGD
Celera7142,407,105 - 142,417,364 (-)RGD
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001122737   ⟹   NP_001116209
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397142,204,505 - 142,211,233 (-)NCBI
GRCm387142,650,768 - 142,657,496 (-)NCBI
MGSCv377149,836,673 - 149,846,940 (-)RGD
Celera7142,407,105 - 142,417,364 (-)RGD
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001315488   ⟹   NP_001302417
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397142,204,505 - 142,220,553 (-)NCBI
GRCm387142,650,768 - 142,666,816 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001315489   ⟹   NP_001302418
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397142,204,505 - 142,211,233 (-)NCBI
GRCm387142,650,768 - 142,657,496 (-)NCBI
Sequence:
RefSeq Acc Id: NM_010514   ⟹   NP_034644
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397142,204,505 - 142,212,541 (-)NCBI
GRCm387142,650,768 - 142,658,804 (-)NCBI
MGSCv377149,836,673 - 149,846,940 (-)RGD
Celera7142,407,105 - 142,417,364 (-)RGD
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006508487   ⟹   XP_006508550
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397142,204,505 - 142,216,007 (-)NCBI
GRCm387142,650,768 - 142,662,270 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030242159   ⟹   XP_030098019
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397142,204,505 - 142,213,222 (-)NCBI
GRCm387142,650,768 - 142,659,485 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036152697   ⟹   XP_036008590
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397142,204,505 - 142,220,566 (-)NCBI
Sequence:
RefSeq Acc Id: NP_034644   ⟸   NM_010514
- Peptide Label: isoform 1 precursor
- UniProtKB: P09535 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001116208   ⟸   NM_001122736
- Peptide Label: isoform 2 preproprotein
- UniProtKB: E9QLW5 (UniProtKB/Swiss-Prot),   P09535 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001116209   ⟸   NM_001122737
- Peptide Label: isoform 2 preproprotein
- UniProtKB: E9QLW5 (UniProtKB/Swiss-Prot),   P09535 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006508550   ⟸   XM_006508487
- Peptide Label: isoform X1
- UniProtKB: E9QLW5 (UniProtKB/Swiss-Prot),   P09535 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001302417   ⟸   NM_001315488
- Peptide Label: isoform 2 preproprotein
- UniProtKB: E9QLW5 (UniProtKB/Swiss-Prot),   P09535 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001302418   ⟸   NM_001315489
- Peptide Label: isoform 2 preproprotein
- UniProtKB: E9QLW5 (UniProtKB/Swiss-Prot),   P09535 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_030098019   ⟸   XM_030242159
- Peptide Label: isoform X2
Ensembl Acc Id: ENSMUSP00000136786   ⟸   ENSMUST00000178921
Ensembl Acc Id: ENSMUSP00000101555   ⟸   ENSMUST00000105935
Ensembl Acc Id: ENSMUSP00000101556   ⟸   ENSMUST00000105936
Ensembl Acc Id: ENSMUSP00000000033   ⟸   ENSMUST00000000033
Ensembl Acc Id: ENSMUSP00000122653   ⟸   ENSMUST00000145896
Ensembl Acc Id: ENSMUSP00000114076   ⟸   ENSMUST00000121128
Ensembl Acc Id: ENSMUSP00000095549   ⟸   ENSMUST00000097936
RefSeq Acc Id: XP_036008590   ⟸   XM_036152697
- Peptide Label: isoform X1
- UniProtKB: P09535 (UniProtKB/Swiss-Prot),   E9QLW5 (UniProtKB/Swiss-Prot)
Protein Domains
Insulin-like   Insulin-like growth factor II E-peptide C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P09535-F1-model_v2 AlphaFold P09535 1-180 view protein structure

Promoters
RGD ID:8666217
Promoter ID:EPDNEW_M11140
Type:initiation region
Name:Igf2_1
Description:Mus musculus insulin-like growth factor 2 , transcript variant4, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M11141  EPDNEW_M11143  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm387142,657,479 - 142,657,539EPDNEW
RGD ID:8666219
Promoter ID:EPDNEW_M11141
Type:initiation region
Name:Igf2_2
Description:Mus musculus insulin-like growth factor 2 , transcript variant4, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M11140  EPDNEW_M11143  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm387142,659,489 - 142,659,549EPDNEW
RGD ID:8666223
Promoter ID:EPDNEW_M11143
Type:initiation region
Name:Igf2_3
Description:Mus musculus insulin-like growth factor 2 , transcript variant4, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M11140  EPDNEW_M11141  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm387142,661,261 - 142,661,321EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:96434 AgrOrtholog
Ensembl Genes ENSMUSG00000048583 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000000033 ENTREZGENE
  ENSMUST00000000033.12 UniProtKB/Swiss-Prot
  ENSMUST00000105935 ENTREZGENE
  ENSMUST00000105935.8 UniProtKB/Swiss-Prot
  ENSMUST00000105936 ENTREZGENE
  ENSMUST00000105936.8 UniProtKB/Swiss-Prot
  ENSMUST00000121128 ENTREZGENE
  ENSMUST00000121128.8 UniProtKB/Swiss-Prot
Gene3D-CATH Insulin-like UniProtKB/Swiss-Prot
InterPro IGF2 UniProtKB/Swiss-Prot
  IGF2_C UniProtKB/Swiss-Prot
  Insulin-like UniProtKB/Swiss-Prot
  Insulin-like_growth_factor UniProtKB/Swiss-Prot
  Insulin-like_sf UniProtKB/Swiss-Prot
  Insulin_CS UniProtKB/Swiss-Prot
  Insulin_family UniProtKB/Swiss-Prot
KEGG Report mmu:16002 UniProtKB/Swiss-Prot
MGD MGI:96434 ENTREZGENE
NCBI Gene 16002 ENTREZGENE
PANTHER INSULIN-LIKE GROWTH FACTOR II UniProtKB/Swiss-Prot
  INSULIN-LIKE GROWTH FACTOR II UniProtKB/Swiss-Prot
Pfam IGF2_C UniProtKB/Swiss-Prot
  Insulin UniProtKB/Swiss-Prot
PhenoGen Igf2 PhenoGen
PRINTS INSLNLIKEGF UniProtKB/Swiss-Prot
  INSLNLIKEGF2 UniProtKB/Swiss-Prot
  INSULINFAMLY UniProtKB/Swiss-Prot
PROSITE INSULIN UniProtKB/Swiss-Prot
SMART IlGF UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56994 UniProtKB/Swiss-Prot
UniProt B0LAD8_MOUSE UniProtKB/TrEMBL
  D3Z4N4_MOUSE UniProtKB/TrEMBL
  E9QLW5 ENTREZGENE
  IGF2_MOUSE UniProtKB/Swiss-Prot
  J3QJZ9_MOUSE UniProtKB/TrEMBL
  P09535 ENTREZGENE
  Q3UJB6_MOUSE UniProtKB/TrEMBL
UniProt Secondary E9QLW5 UniProtKB/Swiss-Prot