Igf1r (insulin-like growth factor I receptor) - Rat Genome Database

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Gene: Igf1r (insulin-like growth factor I receptor) Mus musculus
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Symbol: Igf1r
Name: insulin-like growth factor I receptor
RGD ID: 10766
MGI Page MGI
Description: Enables insulin-like growth factor binding activity and insulin-like growth factor receptor activity. Involved in several processes, including adrenal gland development; insulin-like growth factor receptor signaling pathway; and positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including exocrine pancreas development; positive regulation of mitotic nuclear division; and regulation of intracellular signal transduction. Located in T-tubule and postsynapse. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; brain; genitourinary system; limb; and lung. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; dementia (multiple); kidney cancer (multiple); liver disease (multiple); and neurodegenerative disease (multiple). Orthologous to human IGF1R (insulin like growth factor 1 receptor).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: A330103N21Rik; CD221; D930020L01; hyft; IGF-; IGF-1R; IGF-I receptor; insulin-like growth factor 1 receptor; line 186
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39767,601,486 - 67,883,416 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl767,602,575 - 67,883,416 (+)EnsemblGRCm39 Ensembl
GRCm38767,952,257 - 68,233,668 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl767,952,827 - 68,233,668 (+)EnsemblGRCm38mm10GRCm38
MGSCv37775,097,143 - 75,378,553 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36767,826,372 - 68,100,293 (+)NCBIMGSCv36mm8
Celera765,407,649 - 65,690,413 (+)NCBICelera
Cytogenetic Map7CNCBI
cM Map737.27NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
adrenocortical carcinoma  (ISO)
alcoholic neuropathy  (ISO)
Alzheimer's disease  (IAGP,IEP,IMP,ISO)
amyotrophic lateral sclerosis  (ISO)
atrial fibrillation  (ISO)
breast cancer  (ISO)
Breast Neoplasms  (ISO)
Burns  (ISO)
Cardiomegaly  (IAGP)
cardiomyopathy  (ISO)
Carotid Artery Injuries  (ISO)
Choroidal Neovascularization  (IMP)
chromosome 15q26-qter deletion syndrome  (ISO)
clear cell renal cell carcinoma  (ISO)
congenital diaphragmatic hernia  (ISO)
coronary stenosis  (ISO)
Craniosynostosis Syndrome, Autosomal Recessive  (ISO)
cryptorchidism  (ISO)
dementia  (ISO)
diabetes mellitus  (IAGP,ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
Dwarfism  (ISO)
Endometrial Neoplasms  (ISO)
Experimental Diabetes Mellitus  (IEP,ISO)
Experimental Liver Cirrhosis  (ISO)
fetal alcohol spectrum disorder  (ISO)
Fetal Growth Retardation  (ISO)
gastrinoma  (ISO)
gastroschisis  (ISO)
genetic disease  (ISO)
gestational diabetes  (ISO)
Graves' disease  (ISO)
Growth Disorders  (ISO)
hepatocellular carcinoma  (ISO)
high grade glioma  (ISO)
Huntington's disease  (IMP)
Hyperphagia  (ISO)
hypertension  (ISO)
hyperthyroidism  (ISO)
hypertrophic cardiomyopathy  (ISO)
IgA glomerulonephritis  (ISO)
IGF1R-RELATED DISORDER  (ISO)
intellectual disability  (ISO)
juvenile rheumatoid arthritis  (ISO)
keratoconus  (ISO)
Kidney Reperfusion Injury  (ISO)
Knee Osteoarthritis  (ISO)
Kuhnt-Junius degeneration  (ISO)
Lewy body dementia  (ISO)
liver cirrhosis  (ISO)
lung disease  (ISO)
Malocclusion  (ISO)
Metabolic Bone Diseases  (ISO)
metabolic dysfunction-associated steatotic liver disease  (ISO)
myeloid neoplasm  (ISO)
myocardial infarction  (ISO)
NATURAL KILLER CELL ENTEROPATHY  (ISO)
Neoplasm Metastasis  (ISO)
Neoplastic Cell Transformation  (ISO)
nephroblastoma  (ISO)
neuroblastoma  (ISO)
Neurodevelopmental Disorders  (ISO)
obesity  (ISO)
Optic Nerve Injuries  (ISO)
osteoarthritis  (ISO)
osteoporosis  (ISO)
pancreatic cancer  (ISO)
pancreatic ductal carcinoma  (ISO)
Parkinson's disease  (ISO)
peripheral nervous system disease  (ISO)
portal vein thrombosis  (ISO)
Premature Aging  (IEP)
prostate adenocarcinoma  (IEP,ISO)
prostate cancer  (ISO)
prostate carcinoma  (ISO)
prostatic hypertrophy  (ISO)
Pulmonary Arterial Hypertension  (ISO)
renal cell carcinoma  (ISO)
respiratory failure  (ISO)
Right Ventricular Hypertrophy  (ISO)
Skin Neoplasms  (ISO)
Stroke  (ISO)
toxic encephalopathy  (ISO)
type 2 diabetes mellitus  (ISO)
ulcerative colitis  (ISO)
vascular dementia  (ISO)
vesicoureteral reflux  (ISO)
Zollinger-Ellison syndrome  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(S)-naringenin  (ISO)
(S)-nicotine  (ISO)
(Z)-ligustilide  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP)
1,2-dimethylhydrazine  (EXP,ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 17-glucosiduronic acid  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4-dinitrobenzenesulfonic acid  (EXP)
2-deoxy-D-glucose  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxy-17beta-estradiol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (EXP)
4-vinylcyclohexene dioxide  (EXP)
5,6,7,8-tetrahydrofolic acid  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
acetamide  (ISO)
acetazolamide  (EXP)
afimoxifene  (EXP,ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
amino acid  (EXP)
amitrole  (ISO)
ammonium chloride  (ISO)
androgen antagonist  (ISO)
AP20187  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (EXP,ISO)
azathioprine  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
berberine  (ISO)
beta-hexachlorocyclohexane  (EXP)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
BMS-754807  (ISO)
bortezomib  (ISO)
butan-1-ol  (ISO)
Butylparaben  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcitriol  (ISO)
capsaicin  (ISO)
captan  (EXP)
carbamazepine  (ISO)
carbon nanotube  (EXP)
Chimaphylin  (ISO)
chitin  (ISO)
chloropicrin  (ISO)
chromium(6+)  (ISO)
chrysin  (ISO)
cisplatin  (ISO)
clodronic acid  (ISO)
cocaine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
corosolic acid  (EXP)
corticosterone  (ISO)
cortisol  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
cypermethrin  (ISO)
D-glucose  (ISO)
daidzein  (ISO)
dapsone  (ISO)
DDE  (ISO)
deguelin  (ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (EXP,ISO)
dibenz[a,h]anthracene  (EXP)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
diethylstilbestrol  (EXP)
dihydrofolic acid  (ISO)
dimethylarsinic acid  (ISO)
dioxygen  (ISO)
diquat  (EXP)
Doramectin  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
enzacamene  (ISO)
enzalutamide  (ISO)
equol  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
everolimus  (ISO)
fenpyroximate  (ISO)
fenvalerate  (ISO)
folic acid  (EXP,ISO)
folpet  (EXP)
formaldehyde  (ISO)
FR900359  (ISO)
fructose  (ISO)
fulvestrant  (ISO)
gallic acid  (ISO)
gefitinib  (ISO)
gemcitabine  (ISO)
genistein  (EXP,ISO)
gentamycin  (ISO)
Ginkgoic acid  (ISO)
glucose  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
herbicide  (ISO)
hexachlorobenzene  (ISO)
hydrogen peroxide  (EXP)
Indeno[1,2,3-cd]pyrene  (ISO)
indometacin  (ISO)
isoflurane  (ISO)
isoprenaline  (EXP)
L-ascorbic acid  (EXP)
lead diacetate  (ISO)
lead(0)  (ISO)
leuprolide  (ISO)
linuron  (ISO)
lipopolysaccharide  (ISO)
lovastatin  (ISO)
lycopene  (ISO)
manganese(II) chloride  (ISO)
maslinic acid  (EXP)
masoprocol  (ISO)
melatonin  (ISO)
menadione  (ISO)
metformin  (ISO)
methcathinone  (ISO)
methimazole  (EXP,ISO)
methoxychlor  (ISO)
methyl methanesulfonate  (ISO)
methylarsonic acid  (ISO)
methylmercury chloride  (ISO)
mifepristone  (ISO)
mitoxantrone  (ISO)
monocrotaline  (ISO)
monosodium L-glutamate  (EXP,ISO)
Myrtucommulone A  (EXP)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N,N-diethyl-m-toluamide  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-ethyl-N-nitrosourea  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosomorpholine  (ISO)
N-phosphocreatine  (ISO)
nickel atom  (ISO)
nickel subsulfide  (ISO)
niclosamide  (ISO)
nicotine  (ISO)
nilutamide  (ISO)
nitrofen  (ISO)
nitrogen mustard  (ISO)
ochratoxin A  (ISO)
Octicizer  (EXP,ISO)
ozone  (ISO)
p-menthan-3-ol  (ISO)
palbociclib  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorododecanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (ISO)
phenobarbital  (EXP)
phorbol 13-acetate 12-myristate  (EXP)
picolinic acid  (ISO)
picoxystrobin  (ISO)
picropodophyllotoxin  (EXP,ISO)
piperine  (ISO)
platycodin D  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
pyrimidifen  (ISO)
quercetin  (EXP,ISO)
quercitrin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (EXP,ISO)
RU 58668  (ISO)
rutin  (ISO)
SB 431542  (ISO)
Se-methyl-L-selenocysteine  (ISO)
Se-methylselenocysteine  (ISO)
simvastatin  (EXP,ISO)
sirolimus  (ISO)
sirtinol  (ISO)
sodium arsenate  (EXP)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP)
sophoraflavanone B  (ISO)
sorafenib  (ISO)
streptozocin  (EXP,ISO)
succimer  (ISO)
sucrose  (ISO)
sulfadimethoxine  (ISO)
sunitinib  (ISO)
tamoxifen  (EXP)
tanespimycin  (ISO)
tebufenpyrad  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP,ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (ISO)
tetrathiomolybdate(2-)  (ISO)
thyroxine  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (EXP,ISO)
tunicamycin  (EXP)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)
vitamin E  (ISO)
zinc atom  (ISO)
zinc sulfate  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adrenal gland development  (IGI)
amyloid-beta clearance  (ISO)
animal organ morphogenesis  (IMP)
axonogenesis  (ISO)
brain development  (IMP)
cardiac atrium development  (ISO)
cell surface receptor protein tyrosine kinase signaling pathway  (IEA)
cellular response to aldosterone  (ISO)
cellular response to amyloid-beta  (ISO)
cellular response to angiotensin  (ISO)
cellular response to dexamethasone stimulus  (ISO)
cellular response to estradiol stimulus  (ISO)
cellular response to glucose stimulus  (IBA,IMP,ISO)
cellular response to insulin stimulus  (IMP,ISO)
cellular response to insulin-like growth factor stimulus  (ISO)
cellular response to mechanical stimulus  (ISO)
cellular response to progesterone stimulus  (ISO)
cellular response to testosterone stimulus  (ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
cellular response to zinc ion starvation  (ISO)
cellular senescence  (ISO)
cerebellum development  (ISO)
dendritic spine maintenance  (ISO)
epidermis development  (IMP)
establishment of cell polarity  (ISO)
estrous cycle  (ISO)
exocrine pancreas development  (IMP)
hippocampus development  (ISO)
immune response  (ISO)
insulin receptor signaling pathway  (ISO)
insulin-like growth factor receptor signaling pathway  (IBA,IC,IDA,IGI,IMP,ISO)
male sex determination  (IMP)
mammary gland development  (IMP)
MAPK cascade  (IMP)
mitotic nuclear division  (IMP)
negative regulation of apoptotic process  (ISO)
negative regulation of cholangiocyte apoptotic process  (ISO)
negative regulation of DNA-binding transcription factor activity  (IMP)
negative regulation of hepatocyte apoptotic process  (ISO)
negative regulation of MAPK cascade  (IMP,ISO)
negative regulation of muscle cell apoptotic process  (ISO)
negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IMP)
neuron projection development  (ISO)
peptidyl-tyrosine autophosphorylation  (IDA,ISO)
phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IMP)
phosphorylation  (IEA)
positive regulation of axon regeneration  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of cold-induced thermogenesis  (IMP)
positive regulation of cytokinesis  (ISO)
positive regulation of developmental growth  (IMP)
positive regulation of DNA metabolic process  (ISO)
positive regulation of DNA-templated transcription  (IGI)
positive regulation of kinase activity  (IBA)
positive regulation of MAPK cascade  (IBA,IMP)
positive regulation of meiotic cell cycle  (IGI)
positive regulation of mitotic nuclear division  (IMP)
positive regulation of osteoblast proliferation  (ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IBA,IMP,ISO)
positive regulation of protein-containing complex disassembly  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of steroid hormone biosynthetic process  (ISO)
postsynaptic modulation of chemical synaptic transmission  (EXP,IDA)
prostate gland epithelium morphogenesis  (IMP)
protein autophosphorylation  (ISO)
protein phosphorylation  (IDA)
regulation of JNK cascade  (IBA,ISO)
response to alkaloid  (ISO)
response to ethanol  (ISO)
response to hormone  (ISO)
response to insulin  (ISO)
response to L-glutamate  (ISO)
response to nicotine  (ISO)
response to nutrient levels  (ISO)
response to vitamin E  (ISO)
transcytosis  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal bony labyrinth  (IAGP)
abnormal brainstem morphology  (IAGP)
abnormal breathing pattern  (IAGP)
abnormal bronchiole epithelium morphology  (IAGP)
abnormal calcaneum morphology  (IAGP)
abnormal CNS glial cell morphology  (IAGP)
abnormal cochlea morphology  (IAGP)
abnormal cochlear hair cell development  (IAGP)
abnormal cochlear hair cell stereociliary bundle morphology  (IAGP)
abnormal cochlear inner hair cell morphology  (IAGP)
abnormal cochlear outer hair cell morphology  (IAGP)
abnormal cochlear sensory epithelium morphology  (IAGP)
abnormal epidermal layer morphology  (IAGP)
abnormal fat cell morphology  (IAGP)
abnormal glucose homeostasis  (IAGP)
abnormal gonadal fat pad morphology  (IAGP)
abnormal hair follicle morphology  (IAGP)
abnormal heart left ventricle morphology  (IAGP)
abnormal hindlimb morphology  (IAGP)
abnormal inner hair cell kinocilium morphology  (IAGP)
abnormal lateral semicircular canal morphology  (IAGP)
abnormal liver morphology  (IAGP)
abnormal maternal nurturing  (IAGP)
abnormal muscle morphology  (IAGP)
abnormal myelination  (IAGP)
abnormal myocardial fiber morphology  (IAGP)
abnormal nervous system morphology  (IAGP)
abnormal oligodendrocyte morphology  (IAGP)
abnormal osteoblast physiology  (IAGP)
abnormal osteoclast physiology  (IAGP)
abnormal posterior semicircular canal morphology  (IAGP)
abnormal postnatal growth/weight/body size  (IAGP)
abnormal primary sex determination  (IAGP)
abnormal pulmonary alveolar parenchyma morphology  (IAGP)
abnormal response to injury  (IAGP)
abnormal semicircular canal morphology  (IAGP)
abnormal skeleton morphology  (IAGP)
abnormal skeleton physiology  (IAGP)
abnormal spermatogenesis  (IAGP)
abnormal spinal cord morphology  (IAGP)
abnormal susceptibility to injury induced morbidity/mortality  (IAGP)
abnormal trabecular bone morphology  (IAGP)
abnormal vascular endothelial cell physiology  (IAGP)
abnormal vascular wound healing  (IAGP)
atelectasis  (IAGP)
azoospermia  (IAGP)
cardiac interstitial fibrosis  (IAGP)
congestive heart failure  (IAGP)
cyanosis  (IAGP)
decreased adiponectin level  (IAGP)
decreased airway responsiveness  (IAGP)
decreased birth weight  (IAGP)
decreased body weight  (IAGP)
decreased bone mineralization  (IAGP)
decreased bone ossification  (IAGP)
decreased bone trabecula number  (IAGP)
decreased brain size  (IAGP)
decreased cochlear hair cell number  (IAGP)
decreased cochlear inner hair cell number  (IAGP)
decreased cochlear outer hair cell number  (IAGP)
decreased collagen level  (IAGP)
decreased hair follicle number  (IAGP)
decreased heart left ventricle muscle contractility  (IAGP)
decreased heart rate  (IAGP)
decreased heart weight  (IAGP)
decreased litter size  (IAGP)
decreased locomotor activity  (IAGP)
decreased myocardial fiber size  (IAGP)
decreased oligodendrocyte progenitor number  (IAGP)
decreased osteoblast cell number  (IAGP)
decreased osteoclast cell number  (IAGP)
decreased respiratory mucosa goblet cell number  (IAGP)
decreased survivor rate  (IAGP)
decreased susceptibility to injury  (IAGP)
decreased susceptibility to type I hypersensitivity reaction  (IAGP)
decreased testis weight  (IAGP)
decreased trabecular bone thickness  (IAGP)
decreased trabecular bone volume  (IAGP)
decreased tumor-free survival time  (IAGP)
delayed bone ossification  (IAGP)
dilated cardiomyopathy  (IAGP)
enlarged placenta  (IAGP)
hydrops fetalis  (IAGP)
hyperglycemia  (IAGP)
impaired glucose tolerance  (IAGP)
increased birth weight  (IAGP)
increased body length  (IAGP)
increased body weight  (IAGP)
increased circulating glucose level  (IAGP)
increased fat cell size  (IAGP)
increased heart weight  (IAGP)
increased hepatocyte proliferation  (IAGP)
increased insulin sensitivity  (IAGP)
increased liver weight  (IAGP)
increased mammary gland tumor incidence  (IAGP)
increased total body fat amount  (IAGP)
maternal imprinting  (IAGP)
muscle hypoplasia  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
oligozoospermia  (IAGP)
ovotestis  (IAGP)
perinatal lethality, complete penetrance  (IAGP)
perinatal lethality, incomplete penetrance  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
premature death  (IAGP)
prenatal growth retardation  (IAGP)
primary sex reversal  (IAGP)
respiratory failure  (IAGP)
slow postnatal weight gain  (IAGP)
small hair follicles  (IAGP)
small heart  (IAGP)
small placenta  (IAGP)
small seminiferous tubules  (IAGP)
thin epidermis  (IAGP)
thin epidermis stratum spinosum  (IAGP)
thin interventricular septum  (IAGP)
thin neurocranium  (IAGP)
thin ventricular wall  (IAGP)
translucent skin  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. IGF-I receptor mutations resulting in intrauterine and postnatal growth retardation. Abuzzahab MJ, etal., N Engl J Med. 2003 Dec 4;349(23):2211-22.
2. IGF-1R associates with adverse outcomes after radical radiotherapy for prostate cancer. Aleksic T, etal., Br J Cancer. 2017 Nov 21;117(11):1600-1606. doi: 10.1038/bjc.2017.337. Epub 2017 Oct 3.
3. Effect of testicular damage induced by cryptorchidism on insulin-like growth factor I receptors in rat Sertoli cells. Antich M, etal., J Reprod Fertil. 1995 Jul;104(2):267-75.
4. Myocardial infarction and the myocyte IGF1 autocrine system. Anversa P, etal., Eur Heart J. 1995 Dec;16 Suppl N:37-45.
5. Oxidative stress activates insulin-like growth factor I receptor protein expression, mediating cardiac hypertrophy induced by thyroxine. Araujo AS, etal., Mol Cell Biochem. 2007 Sep;303(1-2):89-95. Epub 2007 Apr 20.
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PMID:24389353   PMID:24391734   PMID:24401233   PMID:24577837   PMID:24598112   PMID:24628914   PMID:24759003   PMID:24782617   PMID:24821966   PMID:24888844   PMID:24952961   PMID:24965872  
PMID:25012136   PMID:25065880   PMID:25084758   PMID:25092896   PMID:25102325   PMID:25211187   PMID:25238791   PMID:25246545   PMID:25255214   PMID:25259518   PMID:25268761   PMID:25269484  
PMID:25271169   PMID:25359884   PMID:25451840   PMID:25502173   PMID:25643582   PMID:25648584   PMID:25651558   PMID:25736226   PMID:25746793   PMID:25783760   PMID:25801198   PMID:25818318  
PMID:25825734   PMID:25910049   PMID:25922525   PMID:25936582   PMID:25981038   PMID:25990470   PMID:26011431   PMID:26076041   PMID:26100875   PMID:26134413   PMID:26141512   PMID:26191255  
PMID:26219530   PMID:26219867   PMID:26235979   PMID:26238476   PMID:26251471   PMID:26290229   PMID:26290394   PMID:26311784   PMID:26364612   PMID:26369386   PMID:26384384   PMID:26389690  
PMID:26469138   PMID:26475121   PMID:26481310   PMID:26567220   PMID:26692333   PMID:26762506   PMID:26792178   PMID:26804653   PMID:26804996   PMID:26848828   PMID:26862168   PMID:26876170  
PMID:26893485   PMID:26901525   PMID:26910308   PMID:27013635   PMID:27103519   PMID:27154724   PMID:27207510   PMID:27207537   PMID:27224923   PMID:27391439   PMID:27417237   PMID:27462832  
PMID:27525440   PMID:27571431   PMID:27643697   PMID:27664421   PMID:27792405   PMID:27798115   PMID:27820945   PMID:27861515   PMID:27870972   PMID:27905925   PMID:28065828   PMID:28096202  
PMID:28096258   PMID:28112398   PMID:28124277   PMID:28130259   PMID:28138037   PMID:28173837   PMID:28207927   PMID:28260056   PMID:28292957   PMID:28315335   PMID:28343662   PMID:28351623  
PMID:28402847   PMID:28407051   PMID:28500773   PMID:28583713   PMID:28595357   PMID:28655914   PMID:28683263   PMID:28683287   PMID:28794445   PMID:28827363   PMID:28881863   PMID:28931726  
PMID:28952285   PMID:29031500   PMID:29040448   PMID:29137928   PMID:29217764   PMID:29272313   PMID:29307582   PMID:29348399   PMID:29398615   PMID:29401624   PMID:29430464   PMID:29545181  
PMID:29631376   PMID:29688375   PMID:29707570   PMID:30070361   PMID:30084987   PMID:30105862   PMID:30126838   PMID:30184089   PMID:30269902   PMID:30354209   PMID:30458886   PMID:30576429  
PMID:30636901   PMID:30718296   PMID:30765523   PMID:30861413   PMID:30900959   PMID:30909860   PMID:31018156   PMID:31088290   PMID:31122676   PMID:31185266   PMID:31318893   PMID:31397024  
PMID:31477557   PMID:31506583   PMID:31536390   PMID:31541165   PMID:31562314   PMID:31563149   PMID:31594955   PMID:31733402   PMID:31908002   PMID:31983537   PMID:32046161   PMID:32075728  
PMID:32147716   PMID:32170969   PMID:32294406   PMID:32325033   PMID:32439763   PMID:32694718   PMID:32697974   PMID:32701997   PMID:32795184   PMID:32805346   PMID:32849999   PMID:32975906  
PMID:32978479   PMID:33141023   PMID:33197537   PMID:33453419   PMID:33480845   PMID:33505018   PMID:33567274   PMID:33591952   PMID:33848471   PMID:33863883   PMID:33911021   PMID:34097060  
PMID:34193412   PMID:34343133   PMID:34359856   PMID:34383203   PMID:34395439   PMID:34407400   PMID:34704401   PMID:34852207   PMID:34921013   PMID:34963058   PMID:35084365   PMID:35185597  
PMID:35320720   PMID:35388142   PMID:35395079   PMID:35545054   PMID:35545672   PMID:35560184   PMID:35688943   PMID:35722884   PMID:35741102   PMID:35840554   PMID:35858325   PMID:35902588  
PMID:35917186   PMID:35921893   PMID:35931212   PMID:35964946   PMID:35974052   PMID:36062186   PMID:36099517   PMID:36125265   PMID:36139407   PMID:36214448   PMID:36353242   PMID:36394300  
PMID:36548088   PMID:36636477   PMID:36843585   PMID:36890580   PMID:36921668   PMID:37291945   PMID:37307487   PMID:37441495   PMID:37474760   PMID:37527036   PMID:37543677   PMID:37664932  
PMID:37685880   PMID:37717026   PMID:37848931   PMID:38017004   PMID:38141612   PMID:38237591   PMID:38262267   PMID:38383709   PMID:38388918   PMID:38425288   PMID:38425784   PMID:38441552  
PMID:38811543   PMID:38816743   PMID:38963344  


Genomics

Comparative Map Data
Igf1r
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39767,601,486 - 67,883,416 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl767,602,575 - 67,883,416 (+)EnsemblGRCm39 Ensembl
GRCm38767,952,257 - 68,233,668 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl767,952,827 - 68,233,668 (+)EnsemblGRCm38mm10GRCm38
MGSCv37775,097,143 - 75,378,553 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36767,826,372 - 68,100,293 (+)NCBIMGSCv36mm8
Celera765,407,649 - 65,690,413 (+)NCBICelera
Cytogenetic Map7CNCBI
cM Map737.27NCBI
IGF1R
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381598,648,539 - 98,964,530 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1598,648,539 - 98,964,530 (+)EnsemblGRCh38hg38GRCh38
GRCh371599,191,768 - 99,507,759 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361597,010,284 - 97,325,282 (+)NCBINCBI36Build 36hg18NCBI36
Build 341597,010,287 - 97,319,034NCBI
Celera1575,609,678 - 75,924,704 (+)NCBICelera
Cytogenetic Map15q26.3NCBI
HuRef1575,320,348 - 75,635,223 (+)NCBIHuRef
CHM1_11599,034,201 - 99,349,171 (+)NCBICHM1_1
T2T-CHM13v2.01596,412,912 - 96,728,919 (+)NCBIT2T-CHM13v2.0
Igf1r
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81130,959,787 - 131,248,664 (+)NCBIGRCr8
mRatBN7.21121,549,831 - 121,838,548 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1121,550,743 - 121,831,777 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1129,548,259 - 129,834,935 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01136,718,334 - 137,005,027 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01129,519,288 - 129,805,989 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01128,924,921 - 129,213,816 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1128,924,966 - 129,206,516 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01129,985,761 - 130,272,589 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41122,704,976 - 122,990,007 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11122,783,318 - 123,068,350 (+)NCBI
Celera1113,751,636 - 114,029,884 (+)NCBICelera
Cytogenetic Map1q22NCBI
Igf1r
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541626,102,628 - 26,382,666 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541626,101,090 - 26,382,660 (-)NCBIChiLan1.0ChiLan1.0
IGF1R
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21688,195,825 - 88,510,506 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11591,892,588 - 92,207,137 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01577,332,926 - 77,648,474 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11596,576,930 - 96,832,974 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1596,535,164 - 96,832,974 (+)Ensemblpanpan1.1panPan2
IGF1R
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1341,795,337 - 42,096,255 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl341,794,623 - 42,090,387 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha344,494,039 - 44,797,005 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0342,203,106 - 42,506,274 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl342,203,091 - 42,501,470 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1341,727,974 - 42,030,799 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0341,958,900 - 42,261,698 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0342,179,556 - 42,481,580 (+)NCBIUU_Cfam_GSD_1.0
Igf1r
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640141,474,253 - 141,770,018 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364834,564,512 - 4,852,925 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364834,563,995 - 4,860,231 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IGF1R
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1137,387,825 - 137,691,058 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11137,383,623 - 137,691,038 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21153,523,944 - 153,853,776 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap1q17-q21NCBI
IGF1R
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12917,212,206 - 17,534,036 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2917,459,404 - 17,526,930 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605929,058,966 - 29,370,219 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Igf1r
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247685,396,156 - 5,681,809 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247685,396,027 - 5,688,435 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Igf1r
10778 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:181
Count of miRNA genes:155
Interacting mature miRNAs:161
Transcripts:ENSMUST00000005671
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
25314306Micab7_mMicrobial abundance of Bacteroidales Porphyromonadaceae Odoribacter 7 (mouse)76675405570749713Mouse
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76502999133501729Mouse
25314305Vmm6_mvariable multisystem mineralization 6, eye (mouse)761849748102749207Mouse
27226778Femd11_mfemur midshaft diameter 11, 16 week (mouse)756949748134001729Mouse
1357586Mdmsc3_mmodifier of muscularity 3 (mouse)Not determined73444786968448018Mouse
26884381Bzwq2_mbi-zygomatic width QTL 2, 5 week (mouse)76524974896949207Mouse
11252140Fdr1_mfat response to dietary restriction 1 (mouse)74114882075148965Mouse
13506761Tbthq1_mtrabecular bone thickness QTL 1 (mouse)76234974867749748Mouse
38501068Tip1_mtuberculosis immunophenotype 1, spleen CFU (mouse)7360299972549748Mouse
1301784Ses2_msalmonella enteritidis susceptibility 2 (mouse)Not determined767290094101290240Mouse
1301663Skull9_mskull morphology 9 (mouse)Not determined75732612191326352Mouse
10043926Bw1n_mbody weight 1 in NSY (mouse)Not determined745161966118693530Mouse
1301383Aem2_manti-erythrocyte autoantibody modifier 2 (mouse)Not determined76413542498135653Mouse
1301514Rigs1_mradiation induced gastroschisis 1 (mouse)Not determined73628001592394346Mouse
27095937Ulnl7_mulna length 7, 10 week (mouse)76644974898349207Mouse
1300878Skts1_mskin tumor susceptibility 1 (mouse)Not determined73789138671891582Mouse
11565101Tsve1_mvariable short tail (Tsv) enhancer 1 (mouse)75588950887142720Mouse
1300620Pgia21_mproteoglycan induced arthritis 21 (mouse)Not determined767290094101290240Mouse
13208555Lgth10_mbody length 10 (mouse)751649748125599172Mouse
26884408Bzwq13_mbi-zygomatic width QTL 13, 16 week (mouse)761749748121399223Mouse
1300791Abbp3_mA/J and C57BL/6 blood pressure 3 (mouse)Not determined739673887103510010Mouse
10402488Dipa2_mdrug induced psychomotor activation 2 (mouse)Not determined73842154872421684Mouse
13432171Rosd1_mrotarod saline difference 1 (mouse)75919437869004862Mouse
10054064Bwq11_mbody weight QTL 11 (mouse)Not determined75112495485125093Mouse
1357752Tabw_mtally ho asscoiated body weight (mouse)Not determined74919327883193390Mouse
10053685Eae43_mexperimental allergic encephalomyelitis susceptibility 43 (mouse)Not determined75112495485125093Mouse
26884404Huml1_mhumerus length 1, 5 week (mouse)730199425108999207Mouse
10045622Heal20_mwound healing/regeneration 20 (mouse)Not determined73431688768317043Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719147398141919804Mouse
10412199Sst2_msusceptibility to tuberculosis 2 (mouse)Not determined718728794119485380Mouse
26884440Sklq4_mskull length QTL 4, 5 week (mouse)765249748126499172Mouse
27226715Metcl3_mmetatarsal-calcaneal length 3, 5 week (mouse)767849748119499223Mouse
26884444Sklq8_mskull length QTL 8, 10 week (mouse)767849748124199223Mouse
25823170Hrsq7_mhost response to SARS QTL 7, log titer (mouse)754819589116822815Mouse
1301082Bbaa16_mB.burgdorferi-associated arthritis 16 (mouse)Not determined736280015116416877Mouse
1301465Egrm3_mearly growth rate (mouse)Not determined75732612191326352Mouse
1300952Hcs1_mhepatocarcinogenesis susceptibility 1 (mouse)Not determined75732612191326352Mouse
1559000Ossc1_mosteosarcoma susceptibility 1 (mouse)Not determined73405302568053223Mouse
1301826Pgia3_mproteoglycan induced arthritis 3 (mouse)Not determined767290094101290240Mouse
12792978Fbmd3_mfemoral bone mineral density 3, females only (mouse)77050288142367832Mouse
4141805Sle19_msystematic lupus erythematosus susceptibility 19 (mouse)Not determined3003248581135653Mouse
4141929Chlq18_mcirculating hormone level QTL 18 (mouse)Not determined74114882075148965Mouse
26884418Bzwq7_mbi-zygomatic width QTL 7, 10 week (mouse)767849748105449207Mouse
27226751Femd5_mfemur midshaft diameter 5, 10 week (mouse)753249748143153737Mouse
1300722Sle3_msystemic lupus erythmatosus susceptibility 3 (mouse)Not determined7351172887142720Mouse
12880417V125Dq5_mvitamin D active form serum level QTL 5 (mouse)74524974879249748Mouse
12880418V125Dq6_mvitamin D active form serum level QTL 6 (mouse)75214974886149748Mouse
11532741Tbrs5_mtuberculosis resistance 5 (mouse)74915922783235415Mouse
1302141Fcsa6_mfemoral cross-sectional area 6 (mouse)Not determined74838446182384607Mouse
13506750Tbthq2_mtrabecular bone thickness QTL 2 (mouse)76565974877549748Mouse
27095916Scvln15_msacral vertebrae length 2, 16 week (mouse)761749748123699223Mouse
12801463Rta1_mretinal aging 1 (mouse)76716802789089989Mouse
26884451Sklq14_mskull length QTL 14, 16 week (mouse)767849748124999172Mouse
11553865Stmm1c_mskin tumor modifier of MSM 1c (mouse)76578898699788986Mouse
11553866Stmm1d_mskin tumor modifier of MSM 1d (mouse)76578898699788986Mouse
25314302Vmm2_mvariable multisystem mineralization 2, heart (mouse)74714974874149748Mouse
25314303Vmm4_mvariable multisystem mineralization 4, kidney (mouse)73729942587049208Mouse
25314301Vmm3_mvariable multisystem mineralization 3, lung (mouse)73729942572049748Mouse

Markers in Region
RH94748  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38767,952,270 - 67,952,390UniSTSGRCm38
MGSCv37775,097,156 - 75,097,276UniSTSGRCm37
Celera765,407,662 - 65,407,782UniSTS
Cytogenetic Map7D1UniSTS
cM Map733.0UniSTS
UniSTS:235686  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38768,230,918 - 68,231,160UniSTSGRCm38
MGSCv37775,375,804 - 75,376,046UniSTSGRCm37
Celera765,687,663 - 65,687,905UniSTS
Cytogenetic Map7D1UniSTS
cM Map733.0UniSTS
PMC149843P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38768,164,746 - 68,165,686UniSTSGRCm38
MGSCv37775,309,632 - 75,310,572UniSTSGRCm37
Celera765,620,631 - 65,621,571UniSTS
Cytogenetic Map7D1UniSTS
cM Map733.0UniSTS
PMC149843P2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38768,165,431 - 68,165,686UniSTSGRCm38
MGSCv37775,310,317 - 75,310,572UniSTSGRCm37
Celera765,621,316 - 65,621,571UniSTS
Cytogenetic Map7D1UniSTS
cM Map733.0UniSTS
UniSTS:224836  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38767,995,383 - 67,995,547UniSTSGRCm38
MGSCv37775,140,269 - 75,140,433UniSTSGRCm37
Cytogenetic Map7D1UniSTS
cM Map733.0UniSTS
BQ204919  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38768,228,635 - 68,228,832UniSTSGRCm38
MGSCv37775,373,521 - 75,373,718UniSTSGRCm37
Celera765,685,380 - 65,685,577UniSTS
Cytogenetic Map7D1UniSTS
cM Map733.0UniSTS
Igf1r  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv37775,328,328 - 75,329,640UniSTSGRCm37
MGSCv37775,148,713 - 75,149,105UniSTSGRCm37
Celera765,640,196 - 65,641,508UniSTS
Celera765,459,542 - 65,459,934UniSTS
Cytogenetic Map7D1UniSTS
cM Map733.0UniSTS
cM Map733.0UniSTS
GDB:187366  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38767,952,310 - 67,952,411UniSTSGRCm38
MGSCv37775,097,196 - 75,097,297UniSTSGRCm37
Celera765,407,702 - 65,407,803UniSTS
Cytogenetic Map7D1UniSTS
cM Map733.0UniSTS
Igf1r  
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