Nr3c1 (nuclear receptor subfamily 3, group C, member 1) - Rat Genome Database

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Gene: Nr3c1 (nuclear receptor subfamily 3, group C, member 1) Mus musculus
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Symbol: Nr3c1
Name: nuclear receptor subfamily 3, group C, member 1
RGD ID: 10691
MGI Page MGI
Description: Enables several functions, including identical protein binding activity; nuclear glucocorticoid receptor activity; and protein kinase binding activity. Involved in several processes, including glial cell differentiation; intracellular glucocorticoid receptor signaling pathway; and positive regulation of miRNA transcription. Acts upstream of or within several processes, including maternal behavior; regulation of glucocorticoid biosynthetic process; and regulation of gluconeogenesis. Located in cytosol; membrane; and nucleus. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and leg muscle. Used to study primary hyperaldosteronism. Human ortholog(s) of this gene implicated in several diseases, including anorexia nervosa; lung disease (multiple); major depressive disorder; obesity; and renal cell carcinoma. Orthologous to human NR3C1 (nuclear receptor subfamily 3 group C member 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: G; glucocorticoid receptor; glucocorticoid receptor 1; glucocorticoid receptor subtype P; GR; Grl; Grl-1; Grl1; nuclear receptor subfamily 3 group C member 1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391839,543,598 - 39,652,485 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1839,543,598 - 39,652,474 (-)EnsemblGRCm39 Ensembl
GRCm381839,410,545 - 39,519,421 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1839,410,545 - 39,519,421 (-)EnsemblGRCm38mm10GRCm38
MGSCv371839,570,199 - 39,646,899 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361839,537,961 - 39,615,820 (-)NCBIMGSCv36mm8
Celera1840,761,405 - 40,838,026 (-)NCBICelera
Cytogenetic Map18B3NCBI
cM Map1821.09NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
46, XX Disorders of Sex Development  (ISO)
anorexia nervosa  (ISO)
asthma  (ISO)
atrial fibrillation  (ISO)
bipolar disorder  (ISO)
brain ischemia  (ISO)
Burns  (ISO)
cataract  (ISO)
chronic obstructive pulmonary disease  (ISO)
cocaine abuse  (ISO)
Cocaine-Related Disorders  (ISO)
congestive heart failure  (ISO)
coronary artery disease  (ISO)
Cushing Syndrome  (IMP,ISO)
depressive disorder  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
Edema  (ISO)
end stage renal disease  (ISO)
endometriosis  (ISO)
Endotoxemia  (ISO)
Experimental Autoimmune Encephalomyelitis  (IMP)
Experimental Diabetes Mellitus  (ISO)
familial adenomatous polyposis 1  (ISO)
fetal alcohol spectrum disorder  (ISO)
Fetal Growth Retardation  (ISO)
genetic disease  (ISO)
Glucocorticoid Receptor Deficiency  (ISO)
glucose metabolism disease  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
hypertension  (IMP,ISO)
hypokalemia  (ISO)
interstitial lung disease  (ISO)
lipoid nephrosis  (ISO)
lung disease  (ISO)
lung non-small cell carcinoma  (ISO)
lupus nephritis  (IEP,ISO)
major depressive disorder  (ISO)
Malocclusion  (ISO)
mood disorder  (ISO)
muscular atrophy  (ISO)
nephrotic syndrome  (ISO)
nephrotic syndrome type 2  (ISO)
Neurodevelopmental Disorders  (ISO)
obesity  (ISO)
obstructive lung disease  (ISO)
obstructive sleep apnea  (ISO)
ocular hypertension  (ISO)
opioid abuse  (ISO)
Perennial Allergic Rhinitis  (ISO)
polycystic ovary syndrome  (ISO)
post-traumatic stress disorder  (ISO)
Prenatal Exposure Delayed Effects  (ISO)
primary biliary cholangitis  (ISO)
primary hyperaldosteronism  (IAGP)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
psychotic disorder  (ISO)
pulmonary sarcoidosis  (ISO)
renal cell carcinoma  (ISO)
rheumatoid arthritis  (ISO)
schizophrenia  (ISO)
Sepsis  (IEP,ISO)
sinusitis  (ISO)
status epilepticus  (ISO)
stress-related disorder  (ISO)
Stroke  (ISO)
Transplant Rejection  (ISO)
type 2 diabetes mellitus  (ISO)
uveitis  (ISO)
visual epilepsy  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(-)-anisomycin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (EXP)
(3,4-dihydroxyphenyl)acetic acid  (EXP)
(S)-amphetamine  (EXP)
(S)-colchicine  (ISO)
(S)-nicotine  (EXP,ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2,3,4,7,8-Hexachlorodibenzofuran  (EXP)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
1,4-dithiothreitol  (ISO)
1-[2-(benzhydryloxy)ethyl]-4-(3-phenylpropyl)piperazine  (EXP)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (ISO)
1-bromopropane  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (ISO)
11-deoxycorticosterone  (ISO)
11-deoxycortisol  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (EXP,ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17alpha-hydroxyprogesterone  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',4,4'-tetrachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,4,7,8-Pentachlorodibenzofuran  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-Trimethylbenzaldehyde  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (EXP)
2-aminophenol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-Dimethylbenzaldehyde  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3,5,6-trichloro-2-pyridinol  (EXP)
3,5,6-trichloropyridine-2-one  (EXP)
3,5-di-tert-Butyl-4-hydroxybenzaldehyde  (ISO)
3-methylcholanthrene  (ISO)
3-phenoxybenzoic acid  (EXP,ISO)
3alpha-hydroxy-5beta-pregnan-20-one  (EXP)
4'-hydroxydiclofenac  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxynon-2-enal  (EXP)
4-hydroxyphenyl retinamide  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-propyl-2-thiouracil  (ISO)
8-Br-cAMP  (ISO)
acetamide  (ISO)
acrolein  (ISO)
actinomycin D  (EXP)
aflatoxin B1  (ISO)
agomelatine  (EXP)
albuterol  (ISO)
aldehydo-D-glucose  (EXP)
aldosterone  (ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-pinene  (ISO)
amiodarone  (ISO)
amitriptyline  (EXP)
ammonium chloride  (ISO)
amphetamine  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
antimycin A  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (EXP)
arsenic acid  (EXP)
arsenic atom  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
Aurin  (ISO)
avobenzone  (ISO)
aziridines  (EXP,ISO)
azoxystrobin  (ISO)
beclomethasone  (ISO)
benzbromarone  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzoyl peroxide  (EXP)
betamethasone  (ISO)
betulin  (ISO)
bifenthrin  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
bleomycin A2  (ISO)
budesonide  (ISO)
butachlor  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (EXP)
Butylparaben  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbamazepine  (EXP,ISO)
carbon nanotube  (EXP)
celecoxib  (ISO)
CGP 52608  (ISO)
chlorpromazine  (EXP)
choline  (EXP)
chromium(6+)  (ISO)
ciclopirox  (ISO)
cidofovir anhydrous  (ISO)
ciglitazone  (EXP)
cisplatin  (EXP,ISO)
citalopram  (ISO)
clodronic acid  (ISO)
clofibrate  (ISO)
clotrimazole  (ISO)
clozapine  (EXP)
cobalt atom  (ISO)
cocaine  (EXP,ISO)
colforsin daropate hydrochloride  (ISO)
compound 48/80  (EXP)
copper(II) sulfate  (ISO)
corticosterone  (EXP,ISO)
corticotropin  (ISO)
cortisol  (EXP,ISO)
cortisone  (ISO)
cortivazol  (ISO)
coumestrol  (ISO)
Cuprizon  (ISO)
curcumin  (ISO)
cycloheximide  (EXP,ISO)
cyclosporin A  (EXP,ISO)
Cyclosporin H  (EXP)
cyhalothrin  (ISO)
cypermethrin  (ISO)
D-glucose  (EXP)
daunorubicin  (ISO)
DDE  (EXP,ISO)
DDT  (ISO)
deflazacort  (ISO)
deguelin  (ISO)
dehydroepiandrosterone  (ISO)
desipramine  (ISO)
dexamethasone  (EXP,ISO)
Diallyl sulfide  (EXP)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
dichloromethane  (EXP)
diclofenac  (ISO)
Dicyclohexyl phthalate  (EXP)
diethyl hydrogen phosphate  (ISO)
diethyl phthalate  (EXP)
Diisodecyl phthalate  (EXP)
diisopropyl fluorophosphate  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
dopamine  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
endrin  (EXP)
entinostat  (ISO)
enzacamene  (ISO)
ethanol  (EXP,ISO)
ethiofencarb  (ISO)
ethyl myristate  (ISO)
farglitazar  (ISO)
fenchone  (ISO)
fenpyroximate  (ISO)
fenvalerate  (ISO)
fludrocortisone  (ISO)
flumethasone  (ISO)
fluoranthene  (EXP)
fluoxetine  (EXP,ISO)
flutamide  (ISO)
fluticasone  (ISO)
folic acid  (EXP,ISO)
folpet  (EXP)
formaldehyde  (ISO)
formoterol fumarate  (ISO)
fulvestrant  (ISO)
fumonisin B1  (EXP)
furan  (ISO)
Fusarenone X  (EXP)
gamma-hexachlorocyclohexane  (ISO)
genistein  (ISO)
gentamycin  (ISO)
geraniol  (ISO)
ginsenoside Re  (ISO)
glafenine  (ISO)
glucose  (EXP)
hexadecanoic acid  (ISO)
homovanillic acid  (EXP)
hydralazine  (ISO)
hydrogen cyanide  (EXP)
hydrogen peroxide  (ISO)
ibuprofen  (EXP,ISO)
idazoxan  (ISO)
irinotecan  (ISO)
isoquinolines  (ISO)
ketoconazole  (EXP,ISO)
L-1,4-dithiothreitol  (ISO)
L-ascorbic acid  (ISO)
L-ethionine  (ISO)
L-methionine  (EXP)
lamotrigine  (ISO)
Laurolactam  (ISO)
lead diacetate  (EXP)
lead(0)  (EXP,ISO)
leflunomide  (ISO)
linuron  (ISO)
lipopolysaccharide  (EXP,ISO)
lithium atom  (EXP,ISO)
lithium chloride  (ISO)
lithium hydride  (EXP,ISO)
LY 379268  (ISO)
medroxyprogesterone acetate  (ISO)
melatonin  (EXP,ISO)
menadione  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (ISO)
metformin  (ISO)
methamphetamine  (EXP,ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
methoxychlor  (ISO)
methylmercury chloride  (ISO)
methylparaben  (EXP)
methylprednisolone aceponate  (ISO)
methylseleninic acid  (ISO)
methyltestosterone  (ISO)
miconazole  (ISO)
mifepristone  (EXP,ISO)
mirex  (ISO)
mitomycin C  (EXP)
mitoxantrone  (ISO)
molybdate  (ISO)
mometasone furoate  (ISO)
Monobutylphthalate  (ISO)
morphine  (ISO)
N,O-dimethyltyramine  (EXP)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-butylbenzenesulfonamide  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
nefazodone  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
nicotine  (EXP,ISO)
nimesulide  (ISO)
nitric oxide  (ISO)
okadaic acid  (EXP)
omeprazole  (ISO)
onapristone  (ISO)
oxaliplatin  (ISO)
oxybenzone  (ISO)
ozone  (EXP,ISO)
paracetamol  (ISO)
paraquat  (ISO)
pararosaniline free base  (ISO)
parathion  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP,ISO)
Phenoxybenzamine  (EXP)
phenylbutazone  (ISO)
phenylephrine  (ISO)
phenylmercury acetate  (ISO)
phenytoin  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phorone  (ISO)
phosgene  (EXP)
pirinixic acid  (EXP,ISO)
Polygodial  (ISO)
potassium chloride  (ISO)
potassium chromate  (ISO)
potassium cyanide  (EXP)
prednisolone  (ISO)
prednisone  (EXP)
prednylidene  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (EXP,ISO)
promegestone  (ISO)
propiconazole  (EXP)
propylparaben  (ISO)
protoporphyrin  (ISO)
puromycin  (EXP)
pyrimidifen  (ISO)
quercetin  (EXP,ISO)
raloxifene  (ISO)
reactive oxygen species  (ISO)
reserpine  (ISO)
resmethrin  (ISO)
resveratrol  (EXP,ISO)
rifampicin  (ISO)
rimonabant  (EXP)
rotenone  (ISO)
S-methyl methanethiosulfonate  (ISO)
Salmeterol xinafoate  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
SCH 23390  (EXP)
selenium atom  (ISO)
selenous acid  (ISO)
senecionine  (ISO)
silicon dioxide  (EXP)
sirolimus  (EXP)
sodium arsenate  (EXP)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP)
spiperone  (EXP)
spiroxamine  (ISO)
succimer  (EXP)
sulfasalazine  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tacrolimus hydrate  (EXP)
tamoxifen  (EXP,ISO)
Tanshinone I  (ISO)
tauroursodeoxycholic acid  (ISO)
tebufenpyrad  (ISO)
tenofovir disoproxil fumarate  (ISO)
terbutaline  (ISO)
teriflunomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
tetramethrin  (ISO)
tetraphene  (ISO)
thifluzamide  (ISO)
thioacetamide  (ISO)
thiram  (ISO)
thyroxine  (ISO)
titanium dioxide  (EXP)
tolcapone  (ISO)
tolterodine tartrate  (ISO)
tolylfluanid  (EXP,ISO)
topotecan  (ISO)
torcetrapib  (ISO)
triamcinolone  (ISO)
triamcinolone acetonide  (EXP,ISO)
tributyl phosphate  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
trifluoperazine  (EXP)
triphenyl phosphate  (ISO)
Triptolide  (ISO)
triptonide  (EXP)
Tris(2-ethylhexyl) phosphate  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
undecan-2-one  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (ISO)
valdecoxib  (ISO)
valproic acid  (EXP,ISO)
venlafaxine hydrochloride  (ISO)
verapamil  (EXP)
vinclozolin  (ISO)
vorinostat  (ISO)
zearalenone  (ISO)
zidovudine  (ISO)
zinc atom  (ISO)
zinc oxide  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adrenal gland development  (IMP)
androgen metabolic process  (ISO)
astrocyte differentiation  (IMP)
cellular response to dexamethasone stimulus  (ISO)
cellular response to glucocorticoid stimulus  (ISO)
cellular response to magnesium ion  (ISO)
cellular response to steroid hormone stimulus  (ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
chromatin organization  (IEA)
chromatin remodeling  (ISO)
circadian rhythm  (ISO)
corticosteroid receptor signaling pathway  (ISO)
female pregnancy  (ISO)
gene expression  (IMP)
glucocorticoid mediated signaling pathway  (IEA)
glucocorticoid metabolic process  (IMP)
lung development  (ISO)
mammary gland duct morphogenesis  (IMP)
maternal behavior  (IGI)
microglia differentiation  (IMP)
motor behavior  (IMP)
muscle atrophy  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of synaptic plasticity  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of vascular permeability  (ISO)
neuroinflammatory response  (IMP)
nuclear receptor-mediated glucocorticoid signaling pathway  (IDA,IMP)
nuclear receptor-mediated steroid hormone signaling pathway  (IBA)
positive regulation of cell growth involved in cardiac muscle cell development  (ISO)
positive regulation of dendritic spine development  (ISO)
positive regulation of glucocorticoid receptor signaling pathway  (ISO)
positive regulation of glutamate secretion  (ISO)
positive regulation of miRNA transcription  (IDA,ISO)
positive regulation of neuron apoptotic process  (IGI)
positive regulation of transcription by RNA polymerase II  (ISO)
regulation of cell population proliferation  (ISO)
regulation of DNA-templated transcription  (IDA,ISO)
regulation of glucocorticoid biosynthetic process  (IMP)
regulation of gluconeogenesis  (IMP)
regulation of glucose metabolic process  (ISO)
regulation of transcription by RNA polymerase II  (IBA)
response to activity  (ISO)
response to arsenic-containing substance  (ISO)
response to calcium ion  (ISO)
response to corticosterone  (ISO)
response to dexamethasone  (ISO)
response to electrical stimulus  (ISO)
response to inactivity  (ISO)
response to insulin  (ISO)
response to mercury ion  (ISO)
synaptic transmission, glutamatergic  (IMP)
transcription initiation-coupled chromatin remodeling  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal adipose tissue distribution  (IAGP)
abnormal adrenal chromaffin cell morphology  (IAGP)
abnormal adrenal cortex morphology  (IAGP)
abnormal adrenal gland morphology  (IAGP)
abnormal adrenal gland zona fasciculata morphology  (IAGP)
abnormal adrenal gland zona glomerulosa morphology  (IAGP)
abnormal adrenal gland zona reticularis morphology  (IAGP)
abnormal alveolocapillary membrane morphology  (IAGP)
abnormal atrial thrombosis  (IAGP)
abnormal behavioral response to addictive substance  (IAGP)
abnormal blood-brain barrier function  (IAGP)
abnormal bone mineral density  (IAGP)
abnormal bone ossification  (IAGP)
abnormal branching involved in terminal bronchiole morphogenesis  (IAGP)
abnormal calcium ion homeostasis  (IAGP)
abnormal cecum morphology  (IAGP)
abnormal circulating corticosterone level  (IAGP)
abnormal fear/anxiety-related behavior  (IAGP)
abnormal heart echocardiography feature  (IAGP)
abnormal humoral immune response  (IAGP)
abnormal hypothalamus physiology  (IAGP)
abnormal interferon level  (IAGP)
abnormal interleukin level  (IAGP)
abnormal interleukin-6 secretion  (IAGP)
abnormal liver physiology  (IAGP)
abnormal lung development  (IAGP)
abnormal lung morphology  (IAGP)
abnormal mammary gland alveolus morphology  (IAGP)
abnormal mammary gland growth during pregnancy  (IAGP)
abnormal monocyte cell number  (IAGP)
abnormal myocardial fiber physiology  (IAGP)
abnormal nervous system electrophysiology  (IAGP)
abnormal osteoblast differentiation  (IAGP)
abnormal osteoblast physiology  (IAGP)
abnormal physiological response to xenobiotic  (IAGP)
abnormal pulmonary alveolus epithelial cell morphology  (IAGP)
abnormal pulmonary alveolus morphology  (IAGP)
abnormal respiratory system development  (IAGP)
abnormal response to CNS ischemic injury  (IAGP)
abnormal surfactant secretion  (IAGP)
abnormal thoracic cavity morphology  (IAGP)
abnormal thymocyte apoptosis  (IAGP)
abnormal tumor necrosis factor level  (IAGP)
absent adrenal medulla  (IAGP)
absent adrenergic chromaffin cells  (IAGP)
absent circulating adrenaline  (IAGP)
absent long-term depression  (IAGP)
atelectasis  (IAGP)
behavioral despair  (IAGP)
cardiac fibrosis  (IAGP)
cardiac hypertrophy  (IAGP)
cecum inflammation  (IAGP)
congestive heart failure  (IAGP)
cyanosis  (IAGP)
decreased adrenal gland zona fasciculata size  (IAGP)
decreased adrenaline level  (IAGP)
decreased anxiety-related response  (IAGP)
decreased B cell number  (IAGP)
decreased body length  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased bone mineral density  (IAGP)
decreased bone trabecula number  (IAGP)
decreased cardiac muscle contractility  (IAGP)
decreased CD4-positive, alpha-beta T cell number  (IAGP)
decreased CD8-positive, alpha-beta T cell number  (IAGP)
decreased circulating adrenocorticotropin level  (IAGP)
decreased circulating corticosterone level  (IAGP)
decreased circulating noradrenaline level  (IAGP)
decreased circulating testosterone level  (IAGP)
decreased double-positive T cell number  (IAGP)
decreased erythroid progenitor cell number  (IAGP)
decreased locomotor activity  (IAGP)
decreased macrophage cell number  (IAGP)
decreased noradrenaline level  (IAGP)
decreased physiological sensitivity to xenobiotic  (IAGP)
decreased single-positive T cell number  (IAGP)
decreased survivor rate  (IAGP)
decreased susceptibility to neuronal excitotoxicity  (IAGP)
decreased T cell apoptosis  (IAGP)
decreased thymocyte apoptosis  (IAGP)
decreased type I pneumocyte number  (IAGP)
dilated heart left ventricle  (IAGP)
enlarged adrenal glands  (IAGP)
enlarged adrenocortical cell nuclei  (IAGP)
enlarged adrenocortical cells  (IAGP)
enlarged heart  (IAGP)
heart inflammation  (IAGP)
hypersecretion of corticotropin-releasing hormone  (IAGP)
impaired lung alveolus development  (IAGP)
increased adrenal gland zona fasciculata size  (IAGP)
increased adrenocorticotropin level  (IAGP)
increased body length  (IAGP)
increased bone trabecular spacing  (IAGP)
increased circulating adrenocorticotropin level  (IAGP)
increased circulating aldosterone level  (IAGP)
increased circulating angiotensinogen level  (IAGP)
increased circulating corticosterone level  (IAGP)
increased circulating glucocorticoid level  (IAGP)
increased heart left ventricle weight  (IAGP)
increased heart weight  (IAGP)
increased interleukin-1 beta secretion  (IAGP)
increased liver triglyceride level  (IAGP)
increased lung weight  (IAGP)
increased mean systemic arterial blood pressure  (IAGP)
increased myocardial fiber size  (IAGP)
increased renin activity  (IAGP)
increased susceptibility to endotoxin shock  (IAGP)
increased susceptibility to experimental autoimmune encephalomyelitis  (IAGP)
increased susceptibility to induced morbidity/mortality  (IAGP)
increased systemic arterial systolic blood pressure  (IAGP)
increased type II pneumocyte number  (IAGP)
lethality, complete penetrance  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
neonatal lethality, incomplete penetrance  (IAGP)
no abnormal phenotype detected  (IAGP)
osteoporosis  (IAGP)
pathological neovascularization  (IAGP)
perinatal lethality, complete penetrance  (IAGP)
perinatal lethality, incomplete penetrance  (IAGP)
poor circulation  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
premature death  (IAGP)
pulmonary hyperplasia  (IAGP)
respiratory distress  (IAGP)
respiratory failure  (IAGP)
small adrenal glands  (IAGP)
thick pulmonary interalveolar septum  (IAGP)
thick ventricular wall  (IAGP)
thin adrenal cortex  (IAGP)
thymus hypoplasia  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. The growth-inhibitory effects of dexamethasone on renal cell carcinoma in vivo and in vitro. Arai Y, etal., Cancer Invest. 2008 Feb;26(1):35-40.
2. Mineralocorticoid and glucocorticoid receptors stimulate epithelial sodium channel activity in a mouse model of Cushing syndrome. Bailey MA, etal., Hypertension. 2009 Oct;54(4):890-6. Epub 2009 Jul 27.
3. Uteroplacental insufficiency alters nephrogenesis and downregulates cyclooxygenase-2 expression in a model of IUGR with adult-onset hypertension. Baserga M, etal., Am J Physiol Regul Integr Comp Physiol. 2007 May;292(5):R1943-55. Epub 2007 Feb 1.
4. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
5. Alpha glucocorticoid receptor expression in different experimental rat models of acute lung injury. Bertorelli G, etal., Pulm Pharmacol Ther. 2008;21(1):214-21. Epub 2007 Mar 24.
6. The aldosterone-mineralocorticoid receptor pathway exerts anti-inflammatory effects in endotoxin-induced uveitis. Bousquet E, etal., PLoS One. 2012;7(11):e49036. doi: 10.1371/journal.pone.0049036. Epub 2012 Nov 9.
7. Glucocorticoid receptor auto-upregulation and its relation with glucocorticoid sensitivity in idiopathic nephrotic syndrome. Chen P, etal., Int Urol Nephrol. 2011 Mar;43(1):167-74. Epub 2010 Apr 24.
8. Glucocorticoid receptor gene polymorphisms associated with progression of lung disease in young patients with cystic fibrosis. Corvol H, etal., Respir Res. 2007 Nov 29;8:88.
9. Glucocorticoid receptor in active pulmonary sarcoidosis. de Carvalho CR, etal., Sarcoidosis. 1990 Sep;7(2):93-5.
10. The glucocorticoid receptor as a potential target to reduce cocaine abuse. Deroche-Gamonet V, etal., J Neurosci. 2003 Jun 1;23(11):4785-90. doi: 10.1523/JNEUROSCI.23-11-04785.2003.
11. Inhibition of glucocorticoid receptor binding by nitric oxide in endotoxemic rats. Duma D, etal., Crit Care Med. 2004 Nov;32(11):2304-10.
12. Modeling corticosteroid effects in a rat model of rheumatoid arthritis I: mechanistic disease progression model for the time course of collagen-induced arthritis in Lewis rats. Earp JC, etal., J Pharmacol Exp Ther. 2008 Aug;326(2):532-45. Epub 2008 Apr 30.
13. Occlusal disharmony increases amyloid-beta in the rat hippocampus. Ekuni D, etal., Neuromolecular Med. 2011 Sep;13(3):197-203. Epub 2011 Jul 13.
14. Glucocorticoid receptor subunit expression in adenotonsillar tissue of children with obstructive sleep apnea. Goldbart AD, etal., Pediatr Res. 2005 Feb;57(2):232-6. Epub 2004 Dec 20.
15. Glomerular glucocorticoid receptor expression is reduced in late responders to steroids in adult-onset minimal change disease. Han SH, etal., Nephrol Dial Transplant. 2008 Jan;23(1):169-75. Epub 2007 Sep 22.
16. [Effect of glucocorticoid on glucocorticoid-resistant children with primary nephrotic syndrome]. He XJ, etal., Zhonghua Er Ke Za Zhi. 2005 Feb;43(2):109-12.
17. Differences in binding of glucocorticoid receptor to DNA in chronic renal graft rejection. Ichimaru N, etal., Transpl Int. 2000;13(4):255-9.
18. Glucocorticoid receptors in anorexia nervosa and Cushing's disease. Invitti C, etal., Biol Psychiatry. 1999 Jun 1;45(11):1467-71.
19. Overexpression of glucocorticoid receptor-beta in severe allergic rhinitis. Ishida A, etal., Auris Nasus Larynx. 2010 Oct;37(5):584-8. Epub 2010 Feb 24.
20. Intrauterine growth retardation affects expression and epigenetic characteristics of the rat hippocampal glucocorticoid receptor gene. Ke X, etal., Physiol Genomics. 2010 Jul 7;42(2):177-89. Epub 2010 Apr 13.
21. Chronic intermittent stress does not differentially alter brain corticosteroid receptor densities in rats prenatally exposed to ethanol. Kim CK, etal., Psychoneuroendocrinology. 1999 Aug;24(6):585-611. doi: 10.1016/s0306-4530(99)00015-3.
22. Expression of glucocorticoid receptor and glucose transporter-1 during placental development in the diabetic rat. Korgun ET, etal., Folia Histochem Cytobiol. 2011;49(2):325-34.
23. Glucocorticoid receptor mRNA levels in bronchial epithelial cells of patients with COPD: influence of glucocorticoids. Korn SH, etal., Respir Med. 1998 Sep;92(9):1102-9.
24. Novel quantitative trait loci for blood pressure and related traits on rat chromosomes 1, 10, and 18. Kovacs P, etal., Biochem Biophys Res Commun 1997 Jun 18;235(2):343-8
25. Glucocorticoid receptor gene polymorphisms in premenopausal women with major depression. Krishnamurthy P, etal., Horm Metab Res. 2008 Mar;40(3):194-8. Epub 2008 Feb 4.
26. Role of corticosterone in anxiety- and depressive-like behavior and HPA regulation following prenatal alcohol exposure. Lam VYY, etal., Prog Neuropsychopharmacol Biol Psychiatry. 2019 Mar 2;90:1-15. doi: 10.1016/j.pnpbp.2018.10.008. Epub 2018 Oct 24.
27. Interactive effects of prenatal alcohol exposure and chronic stress in adulthood on anxiety-like behavior and central stress-related receptor mRNA expression: Sex- and time-dependent effects. Lam VYY, etal., Psychoneuroendocrinology. 2018 Nov;97:8-19. doi: 10.1016/j.psyneuen.2018.06.018. Epub 2018 Jun 23.
28. Prenatal alcohol exposure and prenatal stress differentially alter glucocorticoid signaling in the placenta and fetal brain. Lan N, etal., Neuroscience. 2017 Feb 7;342:167-179. doi: 10.1016/j.neuroscience.2015.08.058. Epub 2015 Sep 2.
29. Glucocorticoid receptor expression in the cortex of the neonatal rat brain with and without focal cerebral ischemia. Lee BH, etal., Neonatology. 2007;91(1):12-9. Epub 2006 Nov 10.
30. Expression of locus coeruleus mineralocorticoid receptor and glucocorticoid receptor in rats under single-prolonged stress. Li M, etal., Neurol Sci. 2011 Aug;32(4):625-31. Epub 2011 May 17.
31. Association of coronary artery disease with glucocorticoid receptor N363S variant. Lin RC, etal., Hypertension. 2003 Mar;41(3):404-7. Epub 2003 Feb 10.
32. Glucocorticoids improve renal responsiveness to atrial natriuretic peptide by up-regulating natriuretic peptide receptor-A expression in the renal inner medullary collecting duct in decompensated heart failure. Liu C, etal., J Pharmacol Exp Ther. 2011 Oct;339(1):203-9. Epub 2011 Jul 7.
33. Changes in glucocorticoid and mineralocorticoid receptors of liver and kidney cytosols after pathologic stress and its regulation in rats. Liu DH, etal., Crit Care Med. 2002 Mar;30(3):623-7.
34. [Effects of ginsenosides on hypothalamic-pituitary-adrenal function and brain-derived neurotrophic factor in rats exposed to chronic unpredictable mild stress]. Liu L, etal., Zhongguo Zhong Yao Za Zhi. 2011 May;36(10):1342-7.
35. [Role of glucocorticoid receptor and nuclear factor-kappaB in patients with stable chronic obstructive pulmonary disease]. Liu T, etal., Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2010 Apr;32(2):147-50. doi: 10.3881/j.issn.1000-503X.2010.02.004.
36. [Effects of a formula of components from Shengmai Powder on glucocorticoid receptor in rats after thermal injury]. Lu X, etal., Zhong Xi Yi Jie He Xue Bao. 2009 Feb;7(2):121-4.
37. Alteration of cadherin in dexamethasone-induced cataract organ-cultured rat lens. Lyu J, etal., Invest Ophthalmol Vis Sci. 2003 May;44(5):2034-40.
38. Corticosterone facilitates the acquisition of cocaine self-administration in rats: opposite effects of the type II glucocorticoid receptor agonist dexamethasone. Mantsch JR, etal., J Pharmacol Exp Ther. 1998 Oct;287(1):72-80.
39. Dopamine-dependent responses to morphine depend on glucocorticoid receptors. Marinelli M, etal., Proc Natl Acad Sci U S A. 1998 Jun 23;95(13):7742-7. doi: 10.1073/pnas.95.13.7742.
40. Functional variability in corticosteroid receptors is a major component of strain differences in fat deposition and metabolic consequences of enriched diets in rat. Marissal-Arvy N, etal., Metabolism. 2010 Aug 17.
41. Meta-analysis on the effect of the N363S polymorphism of the glucocorticoid receptor gene (GRL) on human obesity. Marti A, etal., BMC Med Genet. 2006 May 25;7:50.
42. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
43. MGDs mouse GO annotations MGD data from the GO Consortium
44. MGD IEA MGD IEA
45. Mineralocorticoid receptor antagonism attenuates cardiac hypertrophy and prevents oxidative stress in uremic rats. Michea L, etal., Hypertension. 2008 Aug;52(2):295-300. Epub 2008 Jun 30.
46. Prenatal alcohol exposure alters methyl metabolism and programs serotonin transporter and glucocorticoid receptor expression in brain. Ngai YF, etal., Am J Physiol Regul Integr Comp Physiol. 2015 Sep;309(5):R613-22. doi: 10.1152/ajpregu.00075.2015. Epub 2015 Jul 15.
47. Fluoroquinolones reduce carrageenan-induced edema in rats and the involvement of the glucocorticoid receptor system. Ogino H, etal., J Infect Chemother. 2009 Apr;15(2):113-7. Epub 2009 Apr 25.
48. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
49. Stress-induced activation of ovarian heat shock protein 90 in a rat model of polycystic ovary syndrome. Park E, etal., J Obstet Gynaecol Res. 2012 Feb;38(2):396-407. doi: 10.1111/j.1447-0756.2011.01705.x. Epub 2011 Dec 19.
50. A putative role for hypothalamic glucocorticoid receptors in hypertension induced by prenatal undernutrition in the rat. Perez H, etal., Neurosci Lett. 2010 Oct 8;483(1):41-6. Epub 2010 Jul 30.
51. Modulation of glucocorticoid receptor function and expression in adolescent moderate asthma. Perisic T, etal., Respiration. 2009;77(1):70-5. Epub 2008 Sep 18.
52. The Bcl I single nucleotide polymorphism of the human glucocorticoid receptor gene h-GR/NR3C1 promoter in patients with bronchial asthma: pilot study. Pietras T, etal., Mol Biol Rep. 2010 Nov 27.
53. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
54. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
55. Chaperoning of glucocorticoid receptors. Pratt WB, etal., Handb Exp Pharmacol. 2006;(172):111-38.
56. Impact of adolescent stress on the expression of stress-related receptors in the hippocampus of animals exposed to alcohol prenatally. Raineki C, etal., Hippocampus. 2018 Mar;28(3):201-216. doi: 10.1002/hipo.22823. Epub 2018 Jan 8.
57. Altered control of cellular proliferation in the absence of mammalian brahma (SNF2alpha). Reyes JC, etal., EMBO J 1998 Dec 1;17(23):6979-91.
58. Mouse MP Annotation Import Pipeline RGD automated import pipeline
59. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
60. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
61. Dysfunctional interaction of C/EBPalpha and the glucocorticoid receptor in asthmatic bronchial smooth-muscle cells. Roth M, etal., N Engl J Med. 2004 Aug 5;351(6):560-74.
62. Metabolic gene expression changes in the hippocampus of obese epileptic male rats in the pilocarpine model of temporal lobe epilepsy. Ruiz N, etal., Brain Res. 2011 Dec 2;1426:86-95. Epub 2011 Oct 8.
63. Cloning, expression, and chromosomal localization of a novel cadherin-related protein, protocadherin-3. Sago H, etal., Genomics 1995 Oct 10;29(3):631-40.
64. Changes in the pulmonary glucocorticoid receptor content in the course of interstitial disease. Saldiva PH, etal., Chest. 1985 Sep;88(3):417-9.
65. [Effects of medicinal extract for tonifying kidney to relieve asthma on glucocorticoid receptor expression in lung tissues of rats with bronchial asthma]. Shi KH, etal., Zhong Xi Yi Jie He Xue Bao. 2010 Aug;8(8):785-9.
66. Successful treatment of acute lung injury with pitavastatin in septic mice: potential role of glucocorticoid receptor expression in alveolar macrophages. Takano K, etal., J Pharmacol Exp Ther. 2011 Feb;336(2):381-90. Epub 2010 Nov 5.
67. A pilot study exploring the role of glucocorticoid receptor variants in primary biliary cirrhosis and primary sclerosing cholangitis. ter Borg PC, etal., Neth J Med. 2004 Oct;62(9):326-31.
68. Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety. Tronche F, etal., Nat Genet. 1999 Sep;23(1):99-103.
69. Reduction in glucocorticoid receptors in renal biopsies of patients with lupus nephritis. Tziraki AA, etal., Clin Biochem. 2007 Nov;40(16-17):1188-93. Epub 2007 Aug 21.
70. Enhanced glucocorticoid receptor signaling in T cells impacts thymocyte apoptosis and adaptive immune responses. van den Brandt J, etal., Am J Pathol. 2007 Mar;170(3):1041-53.
71. Hypo-response of the hypothalamic-pituitary-adrenocortical axis after an ethanol challenge in prenatally stressed adolescent male rats. Van Waes V, etal., Eur J Neurosci. 2006 Aug;24(4):1193-200. doi: 10.1111/j.1460-9568.2006.04973.x. Epub 2006 Aug 21.
72. [Effects of neonatal recurrent seizures on glucocorticoid receptor expression in the rat brain]. Wang TM, etal., Zhongguo Dang Dai Er Ke Za Zhi. 2010 Jan;12(1):47-50.
73. Changes of glucocorticoid receptor expression in the nasal polyps of patients with chronic sinusitis following treatment with glucocorticoid. Watanabe S and Suzaki H, In Vivo. 2008 Jan-Feb;22(1):37-42.
74. Effect of artemisinin combined with glucocorticoid on the expressions of glucocorticoid receptor alpha mRNA, glucocorticoid receptor beta mRNA and P300/CBP protein in lupus nephritis mice. Wu XL, etal., Chin J Integr Med. 2011 Apr;17(4):277-82. Epub 2011 Apr 21.
75. [The effect of low-dose hydrocortisone on the expression of glucocorticoid receptor alpha of the septic kidney and its protective effect on kidney in rat]. Wu YX, etal., Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2011 Jul;23(7):426-9.
76. Expression of the glucocorticoid receptor in renal cell neoplasms: an immunohistochemical and quantitative reverse transcriptase polymerase chain reaction study. Yakirevich E, etal., Hum Pathol. 2011 Nov;42(11):1684-92. Epub 2011 Apr 29.
77. The glucocorticoid receptor is required for experimental adrenocorticotrophic hormone-induced hypertension in mice. Zhang Y, etal., Clin Exp Pharmacol Physiol. 2010 Nov;37(11):1044-8. doi: 10.1111/j.1440-1681.2010.05429.x.
78. Differential Regulations of AQP4 and Kir4.1 by Triamcinolone Acetonide and Dexamethasone in the Healthy and Inflamed Retina. Zhao M, etal., Invest Ophthalmol Vis Sci. 2011 Aug 11;52(9):6340-7. Print 2011 Sep.
79. Liver-selective glucocorticoid receptor antagonism decreases glucose production and increases glucose disposal, ameliorating insulin resistance. Zinker B, etal., Metabolism. 2007 Mar;56(3):380-7.
80. Stress-induced glucocorticoid receptor activation determines functional recovery following ischemic stroke. Zucchi FC, etal., Exp Transl Stroke Med. 2010 Sep 22;2(1):18.
Additional References at PubMed
PMID:1354640   PMID:1354644   PMID:1495961   PMID:1528849   PMID:1628813   PMID:1676978   PMID:1679325   PMID:1686018   PMID:1741058   PMID:2019585   PMID:2702670   PMID:2901926  
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PMID:9261129   PMID:9334249   PMID:9473524   PMID:9528750   PMID:9604929   PMID:9699863   PMID:9742105   PMID:9794823   PMID:10048155   PMID:10093711   PMID:10195686   PMID:10212055  
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PMID:14615607   PMID:14691545   PMID:14699442   PMID:15024059   PMID:15028772   PMID:15031319   PMID:15037546   PMID:15051511   PMID:15072571   PMID:15145446   PMID:15199138   PMID:15220338  
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PMID:15731366   PMID:15743993   PMID:15746257   PMID:15761032   PMID:15784617   PMID:15802531   PMID:15834420   PMID:15860252   PMID:15870285   PMID:15987954   PMID:15988691   PMID:16087666  
PMID:16141072   PMID:16141073   PMID:16154291   PMID:16254209   PMID:16326019   PMID:16361444   PMID:16362036   PMID:16390935   PMID:16424199   PMID:16481429   PMID:16554481   PMID:16573657  
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PMID:17683525   PMID:17699665   PMID:17709552   PMID:17878916   PMID:17901120   PMID:17935973   PMID:18023262   PMID:18039792   PMID:18174358   PMID:18206867   PMID:18287559   PMID:18342607  
PMID:18372328   PMID:18408151   PMID:18434569   PMID:18450962   PMID:18464530   PMID:18523311   PMID:18583462   PMID:18612045   PMID:18615595   PMID:18617609   PMID:18657369   PMID:18695245  
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