Nr3c1 (nuclear receptor subfamily 3, group C, member 1) - Rat Genome Database

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Gene: Nr3c1 (nuclear receptor subfamily 3, group C, member 1) Mus musculus
Symbol: Nr3c1
Name: nuclear receptor subfamily 3, group C, member 1
RGD ID: 10691
Description: Enables several functions, including identical protein binding activity; nuclear glucocorticoid receptor activity; and protein kinase binding activity. Involved in several processes, including glial cell differentiation; glucocorticoid receptor signaling pathway; and positive regulation of miRNA transcription. Acts upstream of or within several processes, including maternal behavior; regulation of glucocorticoid biosynthetic process; and regulation of gluconeogenesis. Located in cytosol; membrane; and nucleus. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and leg muscle. Used to study primary hyperaldosteronism. Human ortholog(s) of this gene implicated in several diseases, including anorexia nervosa; lung disease (multiple); major depressive disorder; obesity; and renal cell carcinoma. Orthologous to human NR3C1 (nuclear receptor subfamily 3 group C member 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: G; glucocorticoid receptor; glucocorticoid receptor 1; glucocorticoid receptor subtype P; GR; Grl; Grl-1; Grl1; nuclear receptor subfamily 3 group C member 1
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391839,543,598 - 39,652,485 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1839,543,598 - 39,652,474 (-)EnsemblGRCm39 Ensembl
GRCm381839,410,545 - 39,519,421 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1839,410,545 - 39,519,421 (-)EnsemblGRCm38mm10GRCm38
MGSCv371839,570,199 - 39,646,899 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361839,537,961 - 39,615,820 (-)NCBIMGSCv36mm8
Celera1840,761,405 - 40,838,026 (-)NCBICelera
Cytogenetic Map18B3NCBI
cM Map1821.09NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
46, XX Disorders of Sex Development  (ISO)
anorexia nervosa  (ISO)
asthma  (ISO)
atrial fibrillation  (ISO)
bipolar disorder  (ISO)
brain ischemia  (ISO)
Burns  (ISO)
cataract  (ISO)
chronic obstructive pulmonary disease  (ISO)
Cocaine-Related Disorders  (ISO)
congestive heart failure  (ISO)
coronary artery disease  (ISO)
Cushing Syndrome  (IMP,ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
Edema  (ISO)
end stage renal disease  (ISO)
endometriosis  (ISO)
Endotoxemia  (ISO)
Experimental Autoimmune Encephalomyelitis  (IMP)
Experimental Diabetes Mellitus  (ISO)
familial adenomatous polyposis 1  (ISO)
Fetal Growth Retardation  (ISO)
genetic disease  (ISO)
Glucocorticoid Receptor Deficiency  (ISO)
glucose metabolism disease  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
hypertension  (IMP,ISO)
hypokalemia  (ISO)
interstitial lung disease  (ISO)
lipoid nephrosis  (ISO)
lung disease  (ISO)
lung non-small cell carcinoma  (ISO)
lupus nephritis  (IEP,ISO)
major depressive disorder  (ISO)
Malocclusion  (ISO)
mental depression  (ISO)
mood disorder  (ISO)
muscular atrophy  (ISO)
nephrotic syndrome  (ISO)
nephrotic syndrome type 2  (ISO)
Neurodevelopmental Disorders  (ISO)
obesity  (ISO)
obstructive lung disease  (ISO)
obstructive sleep apnea  (ISO)
ocular hypertension  (ISO)
Perennial Allergic Rhinitis  (ISO)
polycystic ovary syndrome  (ISO)
post-traumatic stress disorder  (ISO)
primary biliary cholangitis  (ISO)
primary hyperaldosteronism  (IAGP)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
psychotic disorder  (ISO)
pulmonary sarcoidosis  (ISO)
renal cell carcinoma  (ISO)
rheumatoid arthritis  (ISO)
schizophrenia  (ISO)
Sepsis  (IEP,ISO)
sinusitis  (ISO)
status epilepticus  (ISO)
Stroke  (ISO)
Transplant Rejection  (ISO)
type 2 diabetes mellitus  (ISO)
uveitis  (ISO)
visual epilepsy  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(-)-anisomycin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(3,4-dihydroxyphenyl)acetic acid  (EXP)
(S)-amphetamine  (EXP)
(S)-colchicine  (ISO)
(S)-nicotine  (EXP,ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2,3,4,7,8-Hexachlorodibenzofuran  (EXP)
1,2-dimethylhydrazine  (EXP)
1,4-dithiothreitol  (ISO)
1-[2-(benzhydryloxy)ethyl]-4-(3-phenylpropyl)piperazine  (EXP)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (ISO)
1-bromopropane  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (ISO)
11-deoxycorticosterone  (ISO)
11-deoxycortisol  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (EXP,ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17alpha-hydroxyprogesterone  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',4,4'-tetrachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,4,7,8-Pentachlorodibenzofuran  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (EXP)
2-aminophenol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-Dimethylbenzaldehyde  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3,5,6-trichloro-2-pyridinol  (EXP)
3,5,6-trichloropyridine-2-one  (EXP)
3,5-di-tert-Butyl-4-hydroxybenzaldehyde  (ISO)
3-methylcholanthrene  (ISO)
3-phenoxybenzoic acid  (EXP,ISO)
3alpha-hydroxy-5beta-pregnan-20-one  (EXP)
4'-hydroxydiclofenac  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxynon-2-enal  (EXP)
4-hydroxyphenyl retinamide  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-propyl-2-thiouracil  (ISO)
8-Br-cAMP  (ISO)
acetamide  (ISO)
acrolein  (ISO)
actinomycin D  (EXP)
aflatoxin B1  (ISO)
agomelatine  (EXP)
albuterol  (ISO)
aldehydo-D-glucose  (EXP)
aldosterone  (ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-pinene  (ISO)
amiodarone  (ISO)
amitriptyline  (EXP)
ammonium chloride  (ISO)
amphetamine  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
antimycin A  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (EXP)
arsenic acid  (EXP)
arsenic atom  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
Aurin  (ISO)
avobenzone  (ISO)
aziridines  (EXP,ISO)
azoxystrobin  (ISO)
beclomethasone  (ISO)
benzbromarone  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzoyl peroxide  (EXP)
betamethasone  (ISO)
betulin  (ISO)
bifenthrin  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
bleomycin A2  (ISO)
budesonide  (ISO)
butachlor  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (EXP)
Butylparaben  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbamazepine  (EXP,ISO)
carbon nanotube  (EXP)
celecoxib  (ISO)
CGP 52608  (ISO)
chlorpromazine  (EXP)
choline  (EXP)
chromium(6+)  (ISO)
ciclopirox  (ISO)
cidofovir anhydrous  (ISO)
ciglitazone  (EXP)
cisplatin  (EXP,ISO)
citalopram  (ISO)
clodronic acid  (ISO)
clofibrate  (ISO)
clotrimazole  (ISO)
clozapine  (EXP)
cobalt atom  (ISO)
cocaine  (EXP,ISO)
colforsin daropate hydrochloride  (ISO)
compound 48/80  (EXP)
copper(II) sulfate  (ISO)
corticosterone  (EXP,ISO)
corticotropin  (ISO)
cortisol  (EXP,ISO)
cortisone  (ISO)
cortivazol  (ISO)
coumestrol  (ISO)
Cuprizon  (ISO)
curcumin  (ISO)
cycloheximide  (EXP,ISO)
cyclosporin A  (EXP,ISO)
cyhalothrin  (ISO)
cypermethrin  (ISO)
D-glucose  (EXP)
daunorubicin  (ISO)
deflazacort  (ISO)
deguelin  (ISO)
dehydroepiandrosterone  (ISO)
desipramine  (ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP,ISO)
dichloromethane  (EXP)
diclofenac  (ISO)
Dicyclohexyl phthalate  (EXP)
diethyl phthalate  (EXP)
Diisodecyl phthalate  (EXP)
diisopropyl fluorophosphate  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
dopamine  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
endrin  (EXP)
entinostat  (ISO)
enzacamene  (ISO)
ethanol  (EXP,ISO)
ethiofencarb  (ISO)
ethyl myristate  (ISO)
fenchone  (ISO)
fenpyroximate  (ISO)
fenvalerate  (ISO)
fludrocortisone  (ISO)
flumethasone  (ISO)
fluoranthene  (EXP)
fluoxetine  (EXP,ISO)
flutamide  (ISO)
fluticasone  (ISO)
folic acid  (EXP,ISO)
folpet  (EXP)
formaldehyde  (ISO)
formoterol fumarate  (ISO)
fulvestrant  (ISO)
fumonisin B1  (EXP)
furan  (ISO)
Fusarenone X  (EXP)
gamma-hexachlorocyclohexane  (ISO)
genistein  (ISO)
gentamycin  (ISO)
geraniol  (ISO)
ginsenoside Re  (ISO)
glafenine  (ISO)
glucose  (EXP)
hexadecanoic acid  (ISO)
homovanillic acid  (EXP)
hydralazine  (ISO)
hydrogen cyanide  (EXP)
hydrogen peroxide  (ISO)
ibuprofen  (EXP,ISO)
idazoxan  (ISO)
irinotecan  (ISO)
isoquinolines  (ISO)
ketoconazole  (EXP,ISO)
L-1,4-dithiothreitol  (ISO)
L-ascorbic acid  (ISO)
L-ethionine  (ISO)
L-methionine  (EXP)
lamotrigine  (ISO)
Laurolactam  (ISO)
lead diacetate  (EXP)
lead(0)  (EXP,ISO)
lead(2+)  (EXP,ISO)
leflunomide  (ISO)
linuron  (ISO)
lipopolysaccharide  (EXP,ISO)
lithium atom  (EXP,ISO)
lithium chloride  (ISO)
lithium hydride  (EXP,ISO)
LY 379268  (ISO)
medroxyprogesterone acetate  (ISO)
melatonin  (EXP,ISO)
menadione  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (ISO)
metformin  (ISO)
methamphetamine  (EXP,ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
methoxychlor  (ISO)
methylmercury chloride  (ISO)
methylparaben  (EXP)
methylprednisolone aceponate  (ISO)
methylseleninic acid  (ISO)
methyltestosterone  (ISO)
miconazole  (ISO)
mifepristone  (EXP,ISO)
mirex  (ISO)
mitomycin C  (EXP)
mitoxantrone  (ISO)
molybdate  (ISO)
mometasone furoate  (ISO)
Monobutylphthalate  (ISO)
morphine  (ISO)
N,O-dimethyltyramine  (EXP)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-butylbenzenesulfonamide  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
nefazodone  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
nicotine  (EXP,ISO)
nimesulide  (ISO)
nitric oxide  (ISO)
okadaic acid  (EXP)
omeprazole  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
pararosaniline free base  (ISO)
parathion  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP,ISO)
Phenoxybenzamine  (EXP)
phenylbutazone  (ISO)
phenylephrine  (ISO)
phenylmercury acetate  (ISO)
phenytoin  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phorone  (ISO)
phosgene  (EXP)
pirinixic acid  (EXP,ISO)
Polygodial  (ISO)
potassium chloride  (ISO)
potassium chromate  (ISO)
potassium cyanide  (EXP)
prednisolone  (ISO)
prednisone  (EXP)
prednylidene  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (EXP,ISO)
promegestone  (ISO)
propiconazole  (EXP)
propylparaben  (ISO)
protoporphyrin  (ISO)
puromycin  (EXP)
pyrimidifen  (ISO)
quercetin  (EXP,ISO)
raloxifene  (ISO)
reactive oxygen species  (ISO)
reserpine  (ISO)
resmethrin  (ISO)
resveratrol  (EXP,ISO)
rifampicin  (ISO)
rimonabant  (EXP)
rotenone  (ISO)
S-methyl methanethiosulfonate  (ISO)
Salmeterol xinafoate  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
SCH 23390  (EXP)
selenium atom  (ISO)
selenous acid  (ISO)
senecionine  (ISO)
silicon dioxide  (EXP)
sirolimus  (EXP)
sodium arsenate  (EXP)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP)
spiperone  (EXP)
spiroxamine  (ISO)
succimer  (EXP)
sulfasalazine  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tacrolimus hydrate  (EXP)
tamoxifen  (EXP,ISO)
Tanshinone I  (ISO)
tauroursodeoxycholic acid  (ISO)
tebufenpyrad  (ISO)
tenofovir disoproxil fumarate  (ISO)
terbutaline  (ISO)
teriflunomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
tetramethrin  (ISO)
tetraphene  (ISO)
thifluzamide  (ISO)
thioacetamide  (ISO)
thiram  (ISO)
thyroxine  (ISO)
titanium dioxide  (EXP)
tolcapone  (ISO)
tolterodine tartrate  (ISO)
tolylfluanid  (EXP,ISO)
topotecan  (ISO)
torcetrapib  (ISO)
triamcinolone  (ISO)
triamcinolone acetonide  (EXP,ISO)
tributyl phosphate  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
trifluoperazine  (EXP)
triphenyl phosphate  (ISO)
Triptolide  (ISO)
triptonide  (EXP)
Tris(2-ethylhexyl) phosphate  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
undecan-2-one  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (ISO)
valdecoxib  (ISO)
valproic acid  (EXP,ISO)
venlafaxine hydrochloride  (ISO)
verapamil  (EXP)
vinclozolin  (ISO)
vorinostat  (ISO)
zearalenone  (ISO)
zidovudine  (ISO)
zinc atom  (ISO)
zinc oxide  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adrenal gland development  (IMP)
aging  (ISO)
androgen metabolic process  (ISO)
astrocyte differentiation  (IMP)
brain development  (ISO)
cellular response to dexamethasone stimulus  (ISO)
cellular response to glucocorticoid stimulus  (ISO)
cellular response to magnesium ion  (ISO)
cellular response to steroid hormone stimulus  (ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
chromatin organization  (IEA)
chromatin remodeling  (ISO)
circadian rhythm  (ISO)
female pregnancy  (ISO)
gene expression  (IMP)
glucocorticoid mediated signaling pathway  (IEA)
glucocorticoid metabolic process  (IMP)
glucocorticoid receptor signaling pathway  (IDA,IMP)
lung development  (ISO)
mammary gland duct morphogenesis  (IMP)
maternal behavior  (IGI)
microglia differentiation  (IMP)
motor behavior  (IMP)
muscle atrophy  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of glucocorticoid mediated signaling pathway  (IDA)
negative regulation of synaptic plasticity  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of vascular permeability  (ISO)
neuroinflammatory response  (IMP)
positive regulation of cell growth involved in cardiac muscle cell development  (ISO)
positive regulation of dendritic spine development  (ISO)
positive regulation of glucocorticoid receptor signaling pathway  (ISO)
positive regulation of glutamate secretion  (ISO)
positive regulation of miRNA transcription  (IDA,ISO)
positive regulation of neuron apoptotic process  (IGI)
positive regulation of transcription by RNA polymerase II  (ISO)
regulation of cell population proliferation  (ISO)
regulation of DNA-templated transcription  (IDA,ISO)
regulation of glucocorticoid biosynthetic process  (IMP)
regulation of gluconeogenesis  (IMP)
regulation of glucose metabolic process  (ISO)
regulation of transcription by RNA polymerase II  (IBA)
response to activity  (ISO)
response to arsenic-containing substance  (ISO)
response to calcium ion  (ISO)
response to corticosterone  (ISO)
response to dexamethasone  (ISO)
response to electrical stimulus  (ISO)
response to inactivity  (ISO)
response to insulin  (ISO)
response to mercury ion  (ISO)
response to radiation  (ISO)
synaptic transmission, glutamatergic  (IMP)
transcription initiation-coupled chromatin remodeling  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal adipose tissue distribution  (IAGP)
abnormal adrenal chromaffin cell morphology  (IAGP)
abnormal adrenal cortex morphology  (IAGP)
abnormal adrenal gland morphology  (IAGP)
abnormal adrenal gland zona fasciculata morphology  (IAGP)
abnormal adrenal gland zona glomerulosa morphology  (IAGP)
abnormal adrenal gland zona reticularis morphology  (IAGP)
abnormal alveolocapillary membrane morphology  (IAGP)
abnormal atrial thrombosis  (IAGP)
abnormal behavioral response to addictive substance  (IAGP)
abnormal blood-brain barrier function  (IAGP)
abnormal bone mineral density  (IAGP)
abnormal bone ossification  (IAGP)
abnormal branching involved in terminal bronchiole morphogenesis  (IAGP)
abnormal calcium ion homeostasis  (IAGP)
abnormal cecum morphology  (IAGP)
abnormal circulating corticosterone level  (IAGP)
abnormal fear/anxiety-related behavior  (IAGP)
abnormal heart echocardiography feature  (IAGP)
abnormal humoral immune response  (IAGP)
abnormal hypothalamus physiology  (IAGP)
abnormal interferon level  (IAGP)
abnormal interleukin level  (IAGP)
abnormal interleukin-6 secretion  (IAGP)
abnormal liver physiology  (IAGP)
abnormal lung development  (IAGP)
abnormal lung morphology  (IAGP)
abnormal mammary gland alveolus morphology  (IAGP)
abnormal mammary gland growth during pregnancy  (IAGP)
abnormal monocyte cell number  (IAGP)
abnormal myocardial fiber physiology  (IAGP)
abnormal nervous system electrophysiology  (IAGP)
abnormal osteoblast differentiation  (IAGP)
abnormal osteoblast physiology  (IAGP)
abnormal physiological response to xenobiotic  (IAGP)
abnormal pulmonary alveolus epithelial cell morphology  (IAGP)
abnormal pulmonary alveolus morphology  (IAGP)
abnormal respiratory system development  (IAGP)
abnormal response to CNS ischemic injury  (IAGP)
abnormal surfactant secretion  (IAGP)
abnormal thoracic cavity morphology  (IAGP)
abnormal thymocyte apoptosis  (IAGP)
abnormal tumor necrosis factor level  (IAGP)
absent adrenal medulla  (IAGP)
absent adrenergic chromaffin cells  (IAGP)
absent circulating adrenaline  (IAGP)
absent long term depression  (IAGP)
atelectasis  (IAGP)
behavioral despair  (IAGP)
cardiac fibrosis  (IAGP)
cardiac hypertrophy  (IAGP)
cecum inflammation  (IAGP)
congestive heart failure  (IAGP)
cyanosis  (IAGP)
decreased adrenaline level  (IAGP)
decreased anxiety-related response  (IAGP)
decreased B cell number  (IAGP)
decreased body length  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased bone mineral density  (IAGP)
decreased bone trabecula number  (IAGP)
decreased cardiac muscle contractility  (IAGP)
decreased CD4-positive, alpha-beta T cell number  (IAGP)
decreased CD8-positive, alpha-beta T cell number  (IAGP)
decreased circulating adrenocorticotropin level  (IAGP)
decreased circulating corticosterone level  (IAGP)
decreased circulating noradrenaline level  (IAGP)
decreased circulating testosterone level  (IAGP)
decreased double-positive T cell number  (IAGP)
decreased erythroid progenitor cell number  (IAGP)
decreased locomotor activity  (IAGP)
decreased macrophage cell number  (IAGP)
decreased noradrenaline level  (IAGP)
decreased physiological sensitivity to xenobiotic  (IAGP)
decreased single-positive T cell number  (IAGP)
decreased survivor rate  (IAGP)
decreased susceptibility to neuronal excitotoxicity  (IAGP)
decreased T cell apoptosis  (IAGP)
decreased thymocyte apoptosis  (IAGP)
decreased type I pneumocyte number  (IAGP)
dilated heart left ventricle  (IAGP)
enlarged adrenal glands  (IAGP)
enlarged adrenocortical cell nuclei  (IAGP)
enlarged adrenocortical cells  (IAGP)
enlarged heart  (IAGP)
enlarged myocardial fiber  (IAGP)
heart inflammation  (IAGP)
hypersecretion of corticotropin-releasing hormone  (IAGP)
impaired lung alveolus development  (IAGP)
increased adrenocorticotropin level  (IAGP)
increased body length  (IAGP)
increased bone trabecular spacing  (IAGP)
increased circulating adrenocorticotropin level  (IAGP)
increased circulating aldosterone level  (IAGP)
increased circulating angiotensinogen level  (IAGP)
increased circulating corticosterone level  (IAGP)
increased circulating glucocorticoid level  (IAGP)
increased heart weight  (IAGP)
increased interleukin-1 beta secretion  (IAGP)
increased left ventricle weight  (IAGP)
increased liver triglyceride level  (IAGP)
increased lung weight  (IAGP)
increased mean systemic arterial blood pressure  (IAGP)
increased renin activity  (IAGP)
increased sensitivity to induced morbidity/mortality  (IAGP)
increased susceptibility to endotoxin shock  (IAGP)
increased susceptibility to experimental autoimmune encephalomyelitis  (IAGP)
increased systemic arterial systolic blood pressure  (IAGP)
increased type II pneumocyte number  (IAGP)
lethality, complete penetrance  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
neonatal lethality, incomplete penetrance  (IAGP)
no abnormal phenotype detected  (IAGP)
osteoporosis  (IAGP)
pathological neovascularization  (IAGP)
perinatal lethality, complete penetrance  (IAGP)
perinatal lethality, incomplete penetrance  (IAGP)
poor circulation  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
premature death  (IAGP)
pulmonary hyperplasia  (IAGP)
respiratory distress  (IAGP)
respiratory failure  (IAGP)
small adrenal glands  (IAGP)
thick pulmonary interalveolar septum  (IAGP)
thick ventricular wall  (IAGP)
thin adrenal cortex  (IAGP)
thymus hypoplasia  (IAGP)

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PMID:29657031   PMID:29672221   PMID:29746256   PMID:29789551   PMID:29795232   PMID:29890290   PMID:29934589   PMID:29941090   PMID:29965797   PMID:30003950   PMID:30006609   PMID:30038578  
PMID:30126083   PMID:30127438   PMID:30188986   PMID:30455377   PMID:30532187   PMID:30580022   PMID:30615908   PMID:30627088   PMID:30649271   PMID:30655507   PMID:30698747   PMID:30742779  
PMID:30824750   PMID:30917317   PMID:30922125   PMID:30936873   PMID:30946837   PMID:30992401   PMID:31149632   PMID:31176306   PMID:31182610   PMID:31189975   PMID:31337711   PMID:31474871  
PMID:31534216   PMID:31559673   PMID:31657630   PMID:31675485   PMID:31711918   PMID:31776290   PMID:31846734   PMID:31869387   PMID:31929189   PMID:32199911   PMID:32226647   PMID:32289320  
PMID:32333646   PMID:32381682   PMID:32460513   PMID:32487073   PMID:32510471   PMID:32571841   PMID:32707034   PMID:32937153   PMID:33065020   PMID:33078371   PMID:33144612   PMID:33316454  
PMID:33510451   PMID:33548499   PMID:33567280   PMID:33650028   PMID:33679723   PMID:33684964   PMID:33790284   PMID:33790465   PMID:33836079   PMID:33852855   PMID:33941859   PMID:34039610  
PMID:34077736   PMID:34145364   PMID:34215821   PMID:34302744   PMID:34308664   PMID:34337361   PMID:34413386   PMID:34639172   PMID:34669484   PMID:34699114   PMID:34731602   PMID:34764952  
PMID:34861075   PMID:34954109   PMID:35007536   PMID:35011674   PMID:35151464   PMID:35263658   PMID:35316097   PMID:35363257   PMID:35568187   PMID:35614477   PMID:35717025   PMID:35733193  
PMID:36012509   PMID:36071319   PMID:36098746   PMID:36100039   PMID:36109497   PMID:36111785   PMID:36172380   PMID:36187119   PMID:36261014   PMID:36403974   PMID:36418174   PMID:36657650  
PMID:36691038   PMID:36834731  


Comparative Map Data
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391839,543,598 - 39,652,485 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1839,543,598 - 39,652,474 (-)EnsemblGRCm39 Ensembl
GRCm381839,410,545 - 39,519,421 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1839,410,545 - 39,519,421 (-)EnsemblGRCm38mm10GRCm38
MGSCv371839,570,199 - 39,646,899 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361839,537,961 - 39,615,820 (-)NCBIMGSCv36mm8
Celera1840,761,405 - 40,838,026 (-)NCBICelera
Cytogenetic Map18B3NCBI
cM Map1821.09NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh385143,277,931 - 143,435,512 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl5143,277,931 - 143,435,512 (-)EnsemblGRCh38hg38GRCh38
GRCh375142,657,496 - 142,815,077 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365142,637,689 - 142,795,270 (-)NCBINCBI36Build 36hg18NCBI36
Build 345142,639,324 - 142,763,087NCBI
Celera5138,738,770 - 138,896,297 (-)NCBICelera
Cytogenetic Map5q31.3NCBI
HuRef5137,804,733 - 137,962,312 (-)NCBIHuRef
CHM1_15142,091,205 - 142,248,804 (-)NCBICHM1_1
T2T-CHM13v2.05143,809,293 - 143,966,896 (-)NCBIT2T-CHM13v2.0
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21831,271,681 - 31,393,320 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1831,271,681 - 31,393,375 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1831,375,854 - 31,463,901 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01832,142,851 - 32,230,932 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01831,471,103 - 31,559,156 (-)NCBIRnor_WKY
Rnor_6.01831,728,373 - 32,704,022 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1831,728,373 - 31,749,647 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01832,347,227 - 32,348,480 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01831,408,742 - 31,442,725 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41832,371,496 - 32,459,145 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11832,406,765 - 32,494,411 (-)NCBI
Celera1830,905,394 - 30,993,522 (-)NCBICelera
RH 3.4 Map18442.9RGD
Cytogenetic Map18p11NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495541510,494,640 - 10,586,221 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541510,494,704 - 10,585,778 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.15144,741,452 - 144,865,341 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5144,741,452 - 144,865,269 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v05138,634,278 - 139,089,171 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1238,124,568 - 38,242,510 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl238,123,190 - 38,240,755 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha235,173,176 - 35,283,390 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0238,573,084 - 38,692,463 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl238,573,084 - 38,690,726 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1235,654,977 - 35,765,222 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0236,468,553 - 36,579,023 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0237,270,194 - 37,380,458 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024407213149,386,116 - 149,482,864 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650410,959,192 - 11,056,856 (+)EnsemblSpeTri2.0
SpeTri2.0NW_00493650410,960,069 - 11,056,834 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl2144,822,939 - 144,956,451 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12144,822,937 - 144,956,451 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22151,051,816 - 151,185,046 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.12345,904,926 - 46,031,804 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2345,904,873 - 46,031,125 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603431,810,840 - 31,935,849 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046247742,495,304 - 2,602,632 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247742,496,276 - 2,603,894 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID

Predicted Target Of
Summary Value
Count of predictions:3814
Count of miRNA genes:787
Interacting mature miRNAs:1069
Transcripts:ENSMUST00000025300, ENSMUST00000097592, ENSMUST00000115567, ENSMUST00000115571, ENSMUST00000124115, ENSMUST00000131885, ENSMUST00000150483, ENSMUST00000152853
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27226723Tibw9_mtibia width 9, proximal, 16 week (mouse)18320000060933072Mouse
1558849W3q15_mweight 3 weeks QTL 15 (mouse)Not determined18504111961272643Mouse
1558873Hrtfm7_mheart failure modifier 7 (mouse)Not determined18808696442087106Mouse
13504732Cath6_mcarotid atherosclerosis 6 (mouse)181363712647637126Mouse
1357603Mom3_mmodifier of Min 3 (mouse)Not determined181403002367098962Mouse
1300994Pvcan3_mprotection against vaginal candidiasis 3 (mouse)Not determined181619964050199776Mouse
1301307Phospq1_mphospholipid QTL 1 (mouse)Not determined181813970452139859Mouse
1300638Im7_mimmunoregulatory 7 (mouse)Not determined181901887453018992Mouse
1558743Kcal1_mkilocalorie 1 (mouse)Not determined181901887453018992Mouse
11532709Sluc41_msusceptibility to lung cancer 41 (mouse)182095369457590708Mouse
13463476Hctq8_mhematocrit QTL 8 (mouse)182121758055217727Mouse
1300877Adip8_madiposity 8 (mouse)Not determined182261991456620127Mouse
11532710Sluc41a_msusceptibility to lung cancer 41a (mouse)182261991456620127Mouse
11532715Sluc41b_msusceptibility to lung cancer 41b (mouse)182261991456620127Mouse
11532716Sluc41c_msusceptibility to lung cancer 41c (mouse)182261991456620127Mouse
1301570Sluc14_msusceptibility to lung cancer 14 (mouse)Not determined182261991456620127Mouse
4142031Moen1_mmodifier of engrailed QTL 1 (mouse)Not determined182411556058115730Mouse
25823173Hrsq12_mhost response to SARS QTL 12, hemorrhage (mouse)182489588178339555Mouse
12904950Smmq3_msoleus muscle mass QTL 3 (mouse)182605687560056875Mouse
25823167Hrsq5_mhost response to SARS QTL 5, D3% weight (mouse)182724111558827077Mouse
25823171Hrsq10_mhost response to SARS QTL 10, D4% weight (mouse)182724111558827077Mouse
25823174Hrsq11_mhost response to SARS QTL 11, log titer (mouse)182724111558827077Mouse
1301400Lmr13_mleishmaniasis resistance 13 (mouse)Not determined182810938062109518Mouse
4141857Mhysq5_mmale hybrid sterility QTL 5 (mouse)Not determined2813060462130739Mouse
1302163Bmd16_mbone mineral density 16 (mouse)Not determined182966791463668060Mouse
12880412V125Dq12_mvitamin D active form serum level QTL 12 (mouse)183023306764233067Mouse
1300685Scc5_mcolon tumor susceptibility 5 (mouse)Not determined183198848065988629Mouse
1357690Vtbt19_mvertebral trabecular bone trait 19 (mouse)Not determined183309104367091221Mouse
1301771Pcyts6_mplasmacytoma susceptibility 6 (mouse)Not determined183565863269658851Mouse
11041903Lmr27_mleishmaniasis resistance 27 (mouse)183618756745109518Mouse
4142366Chlq10_mcirculating hormone level QTL 10 (mouse)Not determined183629102270291180Mouse
15039381Ltgq8_mliver triglyceride QTL 8 (mouse)183820656972206569Mouse
15039383Mvlq5_mmicrovesicular liver lesion QTL 5 (mouse)183820656972206569Mouse
15039384Liviq1_mliver inflammation QTL 1 (mouse)183820656972206569Mouse
15039386Mvlq4_mmacrovesicular liver lesion QTL 4 (mouse)183820656972206569Mouse
12050070Nabq2_mnasal bone morphology QTL 2 (mouse)183910367773103793Mouse
1357639Obsty4_mobesity 4 (mouse)Not determined183961991484638778Mouse

Markers in Region
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381839,414,301 - 39,414,401UniSTSGRCm38
MGSCv371839,573,955 - 39,574,055UniSTSGRCm37
Celera1840,765,161 - 40,765,261UniSTS
Cytogenetic Map18B3UniSTS
cM Map1820.0UniSTS
Whitehead_YAC18 UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381839,486,861 - 39,487,074UniSTSGRCm38
MGSCv371839,646,515 - 39,646,728UniSTSGRCm37
Celera1840,837,669 - 40,837,855UniSTS
Cytogenetic Map18B3UniSTS
cM Map1820.0UniSTS
Whitehead Genetic1814.2UniSTS
Whitehead_YAC18 UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv371839,646,560 - 39,646,767UniSTSGRCm37
MGSCv371839,646,000 - 39,646,463UniSTSGRCm37
Celera1840,837,714 - 40,837,894UniSTS
Celera1840,837,154 - 40,837,617UniSTS
Cytogenetic Map18B3UniSTS
cM Map1820.0UniSTS
cM Map1820.0UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381839,486,346 - 39,486,809UniSTSGRCm38
MGSCv371839,646,000 - 39,646,463UniSTSGRCm37
Celera1840,837,154 - 40,837,617UniSTS
Cytogenetic Map18B3UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map18B3UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381839,486,906 - 39,487,113UniSTSGRCm38
MGSCv371839,646,560 - 39,646,767UniSTSGRCm37
Celera1840,837,714 - 40,837,894UniSTS
Cytogenetic Map18B3UniSTS
cM Map1820.0UniSTS



Nucleotide Sequences
RefSeq Transcripts NM_001361209 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001361210 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001361211 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001361212 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_008173 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006525658 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006525659 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006525660 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006525661 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006525662 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006525663 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006525664 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006525665 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030250338 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030250339 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036160990 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA124418 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC007995 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC124417 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK037733 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK155200 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK156323 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK163857 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK171439 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC008154 (Get FASTA)   NCBI Sequence Viewer