Grin2a (glutamate receptor, ionotropic, NMDA2A (epsilon 1)) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Grin2a (glutamate receptor, ionotropic, NMDA2A (epsilon 1)) Mus musculus
Analyze
Symbol: Grin2a
Name: glutamate receptor, ionotropic, NMDA2A (epsilon 1)
RGD ID: 10686
MGI Page MGI
Description: Enables NMDA glutamate receptor activity and calcium channel activity. Involved in glutamate receptor signaling pathway and regulation of synaptic plasticity. Acts upstream of or within several processes, including excitatory postsynaptic potential; learning or memory; and long-term synaptic potentiation. Located in several cellular components, including cell surface; synaptic membrane; and synaptic vesicle. Part of NMDA selective glutamate receptor complex. Is active in glutamatergic synapse and postsynaptic density membrane. Is expressed in several structures, including central nervous system; eye; hindlimb phalanx; intestine; and limb mesenchyme. Human ortholog(s) of this gene implicated in several diseases, including Huntington's disease; alcohol dependence; bipolar disorder; colorectal cancer; and heroin dependence. Orthologous to human GRIN2A (glutamate ionotropic receptor NMDA type subunit 2A).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Glu; GluN2A; GluRepsilon1; glutamate [NMDA] receptor subunit epsilon-1; glutamate receptor ionotropic, NMDA 2A; N; N-methyl D-aspartate receptor subtype 2A; NMD; NMDAR2A; NR2A
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Gm7328  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39169,385,765 - 9,813,744 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl169,385,762 - 9,813,424 (-)EnsemblGRCm39 Ensembl
GRCm38169,567,901 - 9,996,083 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl169,567,898 - 9,995,560 (-)EnsemblGRCm38mm10GRCm38
MGSCv37169,577,803 - 9,992,626 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36169,491,265 - 9,906,111 (-)NCBIMGSCv36mm8
Celera1610,217,398 - 10,625,063 (-)NCBICelera
Cytogenetic Map16A1NCBI
cM Map165.28NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
alcohol dependence  (IMP,ISO)
Alzheimer's disease  (ISO)
autistic disorder  (ISO)
autosomal dominant intellectual developmental disorder 21  (ISO)
benign epilepsy with centrotemporal spikes  (ISO)
bipolar disorder  (ISO)
Brain Hypoxia-Ischemia  (ISO)
Central Nervous System Viral Diseases  (ISO)
Charcot-Marie-Tooth disease type 1C  (ISO)
cognitive disorder  (ISO)
colorectal cancer  (ISO)
Colorectal Neoplasms  (ISO)
developmental and epileptic encephalopathy 11  (ISO)
Developmental Disabilities  (ISO)
epilepsy  (ISO)
familial temporal lobe epilepsy 1  (ISO)
Fetal Growth Retardation  (ISO)
focal epilepsy  (ISO)
Focal Epilepsy with Speech Disorder and with or without Mental Retardation  (ISO)
GABA aminotransferase deficiency  (ISO)
Generalized Epilepsy  (ISO)
genetic disease  (ISO)
heroin dependence  (ISO)
Huntington's disease  (IEP,ISO)
Hyperalgesia  (ISO)
hyperhomocysteinemia  (ISO)
intellectual disability  (ISO)
Landau-Kleffner syndrome  (ISO)
Language Development Disorders  (ISO)
melanoma  (ISO)
MHC class II deficiency  (ISO)
microcephaly  (ISO)
morphine dependence  (ISO)
nasopharynx carcinoma  (ISO)
neonatal abstinence syndrome  (ISO)
Neuralgia  (ISO)
NEURODEVELOPMENTAL DISORDER WITH MICROCEPHALY, ARTHROGRYPOSIS, AND STRUCTURAL BRAIN ANOMALIES  (ISO)
Neurodevelopmental Disorders  (ISO)
opioid abuse  (ISO)
placental insufficiency  (ISO)
post-traumatic stress disorder  (ISO)
pyridoxine-dependent epilepsy  (ISO)
Reperfusion Injury  (ISO)
schizophrenia  (ISO)
Sepsis  (ISO)
speech disorder  (ISO)
status epilepticus  (ISO)
Tinnitus  (ISO)
transient cerebral ischemia  (IMP,ISO)
vascular dementia  (ISO)
withdrawal disorder  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-pilocarpine  (ISO)
(25R)-cholest-5-ene-3beta,26-diol  (ISO)
(R)-lipoic acid  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP,ISO)
2,3',4,4',5-Pentachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-palmitoylglycerol  (ISO)
26-hydroxycholesterol  (ISO)
3',5'-cyclic AMP  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (EXP)
4-[1-hydroxy-2-[4-(phenylmethyl)-1-piperidinyl]propyl]phenol  (ISO)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
acetamiprid  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
allopurinol  (ISO)
alpha-pinene  (ISO)
Amaranth  (ISO)
ammonium acetate  (ISO)
ammonium chloride  (ISO)
antirheumatic drug  (ISO)
arsane  (EXP)
arsenic atom  (EXP)
arsenite(3-)  (EXP)
astragaloside IV  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Brilliant Blue  (ISO)
caffeine  (ISO)
celecoxib  (EXP)
chaetocin  (ISO)
chlorpyrifos  (EXP,ISO)
choline  (ISO)
chromium(6+)  (ISO)
clozapine  (ISO)
cocaine  (EXP,ISO)
Cuprizon  (ISO)
curcumin  (ISO)
cyanuric acid  (ISO)
cypermethrin  (ISO)
D-aspartic acid  (ISO)
dextromethorphan  (ISO)
Diacetoxyscirpenol  (EXP)
diazepam  (EXP)
diazinon  (ISO)
dinitrogen oxide  (EXP)
diphenyl diselenide  (EXP)
dizocilpine maleate  (EXP,ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
entinostat  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
ethylparaben  (ISO)
excitatory amino acid agonist  (ISO)
felbamate  (ISO)
fentanyl  (ISO)
Fluorocitric acid  (ISO)
fluoxetine  (ISO)
folic acid  (ISO)
formaldehyde  (EXP)
FR900359  (ISO)
fulvestrant  (ISO)
furan  (ISO)
genistein  (ISO)
haloperidol  (ISO)
hydrogen peroxide  (ISO)
indigo carmine  (ISO)
isocyanuric acid  (ISO)
kainic acid  (EXP)
ketamine  (EXP,ISO)
L-ascorbic acid  (ISO)
lanthanum trichloride  (ISO)
lead diacetate  (EXP,ISO)
lead nitrate  (EXP)
leflunomide  (ISO)
linoleic acid  (ISO)
lipoic acid  (ISO)
lipoteichoic acid  (EXP)
lithium atom  (ISO)
lithium hydride  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
memantine  (EXP)
mercury dibromide  (ISO)
methamphetamine  (ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
midazolam  (EXP)
minocycline  (ISO)
morphine  (EXP)
N-methyl-N-nitrosourea  (ISO)
nickel atom  (ISO)
nobiletin  (ISO)
Nor-9-carboxy-delta9-THC  (ISO)
ochratoxin A  (ISO)
oxybenzone  (ISO)
ozone  (EXP)
p-chloromercuribenzoic acid  (ISO)
panobinostat  (ISO)
paraquat  (EXP,ISO)
PCB138  (EXP)
pentobarbital  (EXP,ISO)
phencyclidine  (EXP)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP)
poly(cytidylic acid)  (ISO)
profenofos  (ISO)
propofol  (EXP)
prostaglandin E2  (EXP)
rimonabant  (EXP)
SB 431542  (ISO)
sevoflurane  (EXP)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (EXP)
sterigmatocystin  (ISO)
sulfur dioxide  (ISO)
Sunset Yellow FCF  (ISO)
suvorexant  (EXP)
T-2 toxin  (EXP)
tadalafil  (EXP)
tannic acid  (ISO)
tartrazine  (ISO)
tetrodotoxin  (EXP)
thalidomide  (ISO)
thioacetamide  (EXP)
titanium dioxide  (EXP)
toluene  (EXP,ISO)
tributylstannane  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
venlafaxine hydrochloride  (ISO)
vinclozolin  (ISO)
zinc atom  (ISO)
zinc dichloride  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
action potential  (ISO)
auditory behavior  (ISO)
calcium ion transmembrane import into cytosol  (ISO,ISS)
calcium ion transmembrane transport  (ISO)
calcium ion transport  (IGI,IMP)
calcium-mediated signaling  (IEA)
cellular response to amino acid stimulus  (ISO)
cellular response to amyloid-beta  (ISO)
cellular response to dsRNA  (ISO)
cellular response to glycine  (ISO)
cellular response to growth factor stimulus  (ISO)
cellular response to lipid  (ISO)
cellular response to magnesium ion  (ISO)
cellular response to manganese ion  (ISO)
cellular response to zinc ion  (ISO)
cerebral cortex development  (ISO)
chemical synaptic transmission  (IMP,ISO)
conditioned place preference  (ISO)
dendritic spine organization  (ISO)
detection of mechanical stimulus involved in sensory perception of pain  (IMP)
directional locomotion  (IGI)
dopamine metabolic process  (IMP)
excitatory postsynaptic potential  (IBA,IGI,IMP,ISO)
glutamate receptor signaling pathway  (IDA)
hippocampus development  (ISO)
ionotropic glutamate receptor signaling pathway  (ISO,ISS)
learning  (IMP)
learning or memory  (IMP)
locomotion  (IMP)
locomotory behavior  (TAS)
long-term synaptic potentiation  (IBA,IGI,IMP,ISO)
memory  (IMP,ISO)
modulation of chemical synaptic transmission  (IMP)
modulation of excitatory postsynaptic potential  (ISO)
monoatomic cation transmembrane transport  (ISO,ISS)
multicellular organismal response to stress  (ISO)
negative regulation of protein catabolic process  (IGI)
neurogenesis  (IMP)
neuron development  (ISO)
neurotransmitter receptor transport, plasma membrane to endosome  (ISO)
positive regulation of apoptotic process  (IGI)
positive regulation of excitatory postsynaptic potential  (ISO,ISS)
positive regulation of inhibitory postsynaptic potential  (ISO)
positive regulation of protein targeting to membrane  (ISO)
positive regulation of synaptic transmission, glutamatergic  (ISO,ISS)
protein catabolic process  (IGI)
protein localization to postsynaptic membrane  (IGI,IMP)
receptor recycling  (ISO)
regulation of ARF protein signal transduction  (ISO)
regulation of long-term neuronal synaptic plasticity  (ISO)
regulation of membrane potential  (IMP,ISO)
regulation of monoatomic cation transmembrane transport  (ISO,ISS)
regulation of neuronal synaptic plasticity  (NAS)
regulation of NMDA receptor activity  (ISO)
regulation of postsynaptic membrane potential  (IMP)
regulation of response to alcohol  (ISO)
regulation of synaptic plasticity  (IDA,IMP)
response to amine  (ISO)
response to ammonium ion  (ISO)
response to amphetamine  (IMP)
response to calcium ion  (ISO)
response to carbohydrate  (ISO)
response to cocaine  (ISO)
response to environmental enrichment  (ISO)
response to ethanol  (IMP,ISO)
response to fungicide  (ISO)
response to glycoside  (ISO)
response to hydrogen sulfide  (ISO)
response to lead ion  (ISO)
response to light stimulus  (ISO)
response to lithium ion  (ISO)
response to manganese ion  (ISO)
response to methylmercury  (ISO)
response to nicotine  (ISO)
response to other organism  (ISO)
response to wounding  (IGI,IMP)
response to xenobiotic stimulus  (IMP,ISO)
rhythmic process  (ISO)
sensory perception of pain  (IMP)
serotonin metabolic process  (IMP)
sleep  (IMP)
sodium ion transmembrane transport  (IEA)
spinal cord development  (ISO)
startle response  (IGI,IMP)
synaptic transmission, glutamatergic  (IBA)
visual learning  (IMP)

Molecular Pathway Annotations     Click to see Annotation Detail View
alfentanil pharmacodynamics pathway   (ISO)
Alzheimer's disease pathway  (IEA)
amyotrophic lateral sclerosis pathway  (IEA)
bupivacaine pharmacodynamics pathway  (ISO)
buprenorphine pharmacodynamics pathway   (ISO)
calcium/calmodulin dependent kinase 2 signaling pathway  (ISO)
chloroprocaine pharmacodynamics pathway  (ISO)
citalopram pharmacodynamics pathway  (ISO)
cocaine pharmacodynamics pathway  (ISO)
codeine and morphine pharmacodynamics pathway  (ISO)
desipramine pharmacodynamics pathway  (ISO)
diphenoxylate pharmacodynamics pathway  (ISO)
escitalopram pharmacodynamics pathway  (ISO)
ethylmorphine pharmacodynamics pathway  (ISO)
excitatory synaptic transmission pathway  (ISO)
fentanyl pharmacodynamics pathway  (ISO)
fluoxetine pharmacodynamics pathway  (ISO)
glutamate signaling pathway  (IEA)
heroin pharmacodynamics pathway  (ISO)
hydrocodone pharmacodynamics pathway  (ISO)
hydromorphone pharmacodynamics pathway  (ISO)
imipramine pharmacodynamics pathway  (ISO)
levacetylmethadol pharmacodynamics pathway  (ISO)
levobupivacaine phgarmacodynamics pathway  (ISO)
levorphanol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
long term depression  (ISO)
long term potentiation  (IEA,ISO)
mepivacaine pharmacodynamics pathway  (ISO)
methadone pharmacodynamics pathway  (ISO)
methadone pharmacokinetics pathway  (ISO)
nalbuphine pharmacodynamics pathway  (ISO)
naloxone pharmacodynamics pathway  (ISO)
naltrexone pharmacodynamics pathway  (ISO)
nicotine pharmacodynamics pathway  (ISO)
oxybuprocaine pharmacodynamics pathway  (ISO)
oxycodone pharmacodynamics pathway  (ISO)
oxymorphone pharmacodynamics pathway  (ISO)
pentazocine pharmacodynamics pathway  (ISO)
prilocaine pharmacodynamics pathway  (ISO)
procaine pharmacodynamics pathway   (ISO)
Reelin signaling pathway  (ISO)
remifentanil pharmacodynamics pathway  (ISO)
ropivacaine pharmacodynamics pathway  (ISO)
systemic lupus erythematosus pathway  (IEA)
tramadol pharmacodynamics pathway  (ISO)

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Potential involvement of GRIN2B encoding the NMDA receptor subunit NR2B in the spectrum of Alzheimer's disease. Andreoli V, etal., J Neural Transm (Vienna). 2014 May;121(5):533-42. doi: 10.1007/s00702-013-1125-7. Epub 2013 Dec 1.
2. NR2A and NR2B receptor gene variations modify age at onset in Huntington disease in a sex-specific manner. Arning L, etal., Hum Genet. 2007 Sep;122(2):175-82. Epub 2007 Jun 14.
3. NR2A and NR2B receptor gene variations modify age at onset in Huntington disease. Arning L, etal., Neurogenetics. 2005 Feb;6(1):25-8. Epub 2004 Nov 17.
4. Differential roles of NR2A and NR2B-containing NMDA receptors in LTP and LTD in the CA1 region of two-week old rat hippocampus. Bartlett TE, etal., Neuropharmacology. 2007 Jan;52(1):60-70. Epub 2006 Aug 10.
5. Association between NMDA receptor subunit 2b gene polymorphism and Alzheimer's disease in Chinese Han population in Shanghai. Chen C, etal., Neurosci Bull. 2010 Oct;26(5):395-400. doi: 10.1007/s12264-010-0729-2.
6. CaMKII regulation in information processing and storage. Coultrap SJ and Bayer KU, Trends Neurosci. 2012 Oct;35(10):607-18. doi: 10.1016/j.tins.2012.05.003. Epub 2012 Jun 19.
7. N-methyl-D-aspartate glutamate receptor blockade attenuates lung injury associated with experimental sepsis. da Cunha AA, etal., Chest. 2010 Feb;137(2):297-302. Epub 2009 Oct 16.
8. NMDA receptor subunits change in the prefrontal cortex of pure-opioid and multi-drug abusers: a post-mortem study. Daneshparvar H, etal., Eur Arch Psychiatry Clin Neurosci. 2019 Apr;269(3):309-315. doi: 10.1007/s00406-018-0900-8. Epub 2018 May 16.
9. Association between a polymorphism in the promoter of a glutamate receptor subunit gene (GRIN2A) and alcoholism. Domart MC, etal., Addict Biol. 2012 Jul;17(4):783-5. doi: 10.1111/j.1369-1600.2011.00321.x. Epub 2011 Apr 20.
10. Early modifications in N-methyl-D-aspartate receptor subunit mRNA levels in an oxygen and glucose deprivation model using rat hippocampal brain slices. Dos-Anjos S, etal., Neuroscience. 2009 Dec 15;164(3):1119-26. Epub 2009 Sep 15.
11. Altered NMDA receptor trafficking in a yeast artificial chromosome transgenic mouse model of Huntington's disease. Fan MM, etal., J Neurosci. 2007 Apr 4;27(14):3768-79.
12. Viral-like brain inflammation during development causes increased seizure susceptibility in adult rats. Galic MA, etal., Neurobiol Dis. 2009 Nov;36(2):343-51. Epub 2009 Aug 4.
13. Effects of salicylate on the inflammatory genes expression and synaptic ultrastructure in the cochlear nucleus of rats. Hu SS, etal., Inflammation. 2014 Apr;37(2):365-73. doi: 10.1007/s10753-013-9748-2.
14. Characterization of genomic alterations in Chinese colorectal cancer patients. Huang W, etal., Jpn J Clin Oncol. 2021 Jan 1;51(1):120-129. doi: 10.1093/jjco/hyaa182.
15. Prenatal development of NMDA receptor composition and function in trigeminal neurons. Ishihama K, etal., Arch Histol Cytol. 2005 Dec;68(4):321-35.
16. Genetic analysis of a functional GRIN2A promoter (GT)n repeat in bipolar disorder pedigrees in humans. Itokawa M, etal., Neurosci Lett 2003 Jul 10;345(1):53-6.
17. Sigma-1 receptor activation ameliorates anxiety-like behavior through NR2A-CREB-BDNF signaling pathway in a rat model submitted to single-prolonged stress. Ji LL, etal., Mol Med Rep. 2017 Oct;16(4):4987-4993. doi: 10.3892/mmr.2017.7185. Epub 2017 Aug 7.
18. CaMKII-dependent dendrite ramification and spine generation promote spatial training-induced memory improvement in a rat model of sporadic Alzheimer's disease. Jiang X, etal., Neurobiol Aging. 2015 Feb;36(2):867-76. doi: 10.1016/j.neurobiolaging.2014.10.018. Epub 2014 Oct 16.
19. Hyperhomocysteinemia leads to exacerbation of ischemic brain damage: Role of GluN2A NMDA receptors. Jindal A, etal., Neurobiol Dis. 2019 Jul;127:287-302. doi: 10.1016/j.nbd.2019.03.012. Epub 2019 Mar 15.
20. NMDA receptor GluN2A subunit deletion protects against dependence-like ethanol drinking. Jury NJ, etal., Behav Brain Res. 2018 Nov 1;353:124-128. doi: 10.1016/j.bbr.2018.06.029. Epub 2018 Jun 25.
21. The N-methyl-D-aspartate receptor type 2A is frequently methylated in human colorectal carcinoma and suppresses cell growth. Kim MS, etal., Oncogene. 2008 Mar 27;27(14):2045-54. doi: 10.1038/sj.onc.1210842. Epub 2007 Oct 8.
22. Pathological reorganization of NMDA receptors subunits and postsynaptic protein PSD-95 distribution in Alzheimer's disease. Leuba G, etal., Curr Alzheimer Res. 2014 Jan;11(1):86-96.
23. The role of reelin in adult synaptic function and the genetic and epigenetic regulation of the reelin gene. Levenson JM, etal., Biochim Biophys Acta. 2008 Aug;1779(8):422-31. Epub 2008 Jan 12.
24. Role of NMDA receptor subtypes in different forms of NMDA-dependent synaptic plasticity. Li R, etal., BMC Neurosci. 2007 Jul 26;8:55.
25. Lithium reduced N-methyl-D-aspartate receptor subunit 2A tyrosine phosphorylation and its interactions with Src and Fyn mediated by PSD-95 in rat hippocampus following cerebral ischemia. Ma J and Zhang GY, Neurosci Lett. 2003 Sep 18;348(3):185-9. doi: 10.1016/s0304-3940(03)00784-5.
26. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
27. MGDs mouse GO annotations MGD data from the GO Consortium
28. MGD IEA MGD IEA
29. Differential alterations of neocortical GluN receptor subunits in patients with mixed subcortical ischemic vascular dementia and Alzheimer's disease. Mohamed NE, etal., J Alzheimers Dis. 2015;44(2):431-7. doi: 10.3233/JAD-141764.
30. Age and meloxicam attenuate the ischemia/reperfusion-induced down-regulation in the NMDA receptor genes. Montori S, etal., Neurochem Int. 2010 Jul;56(8):878-85. Epub 2010 Mar 27.
31. Cortical neurons from intrauterine growth retardation rats exhibit lower response to neurotrophin BDNF. Ninomiya M, etal., Neurosci Lett. 2010 May 31;476(2):104-9. Epub 2010 Apr 14.
32. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
33. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
34. Content of mRNA for NMDA glutamate receptor subunits in the frontal cortex and striatum of rats after morphine withdrawal is related to the degree of abstinence. Peregud DI, etal., Bull Exp Biol Med. 2012 Oct;153(6):835-8. doi: 10.1007/s10517-012-1838-x.
35. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
36. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
37. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
38. Mouse MP Annotation Import Pipeline RGD automated import pipeline
39. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
40. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
41. Intrauterine growth restriction due to uteroplacental insufficiency decreased white matter and altered NMDAR subunit composition in juvenile rat hippocampi. Schober ME, etal., Am J Physiol Regul Integr Comp Physiol. 2009 Mar;296(3):R681-92. Epub 2009 Jan 14.
42. Significant linkage and association between a functional (GT)n polymorphism in promoter of the N-methyl-D-aspartate receptor subunit gene (GRIN2A) and schizophrenia. Tang J, etal., Neurosci Lett. 2006 Nov 27;409(1):80-2. Epub 2006 Oct 2.
43. Hippocampal NMDAR-Wnt-Catenin signaling disrupted with cognitive deficits in adolescent offspring exposed to prenatal hypoxia. Wei B, etal., Brain Res. 2016 Jan 15;1631:157-64. doi: 10.1016/j.brainres.2015.11.041. Epub 2015 Dec 2.
44. Disease-specific alterations in glutamatergic neurotransmission on inhibitory interneurons in the prefrontal cortex in schizophrenia. Woo TU, etal., Brain Res. 2008 Jul 7;1218:267-77. Epub 2008 Apr 16.
45. Cdk5 inhibitor roscovitine alleviates neuropathic pain in the dorsal root ganglia by downregulating N-methyl-D-aspartate receptor subunit 2A. Yang L, etal., Neurol Sci. 2014 Sep;35(9):1365-71. doi: 10.1007/s10072-014-1713-9.
46. Disruption of SHP1/NMDA receptor signaling in spinal cord dorsal horn alleviated inflammatory pain. Yang L, etal., Neuropharmacology. 2018 Jul 15;137:104-113. doi: 10.1016/j.neuropharm.2018.04.029. Epub 2018 Apr 30.
47. The escalation in ethanol consumption following chronic intermittent ethanol exposure is blunted in mice expressing ethanol-resistant GluN1 or GluN2A NMDA receptor subunits. Zamudio PA, etal., Psychopharmacology (Berl). 2021 Jan;238(1):271-279. doi: 10.1007/s00213-020-05680-z. Epub 2020 Oct 14.
48. Analysis of variations in the glutamate receptor, N-methyl D-aspartate 2A (GRIN2A) gene reveals their relative importance as genetic susceptibility factors for heroin addiction. Zhao B, etal., PLoS One. 2013 Aug 5;8(8):e70817. doi: 10.1371/journal.pone.0070817. Print 2013.
49. Functional polymorphisms of the glutamate receptor N-methyl D-aspartate 2A gene are associated with heroin addiction. Zhong HJ, etal., Genet Mol Res. 2014 Oct 27;13(4):8714-21. doi: 10.4238/2014.October.27.12.
50. Expression of GRIN2A in benign and malignant nasopharyngeal diseases and its clinical significance. Zhou XJ, etal., Genet Mol Res. 2015 Dec 17;14(4):17289-95. doi: 10.4238/2015.December.16.29.
Additional References at PubMed
PMID:1374164   PMID:1377365   PMID:1385220   PMID:1493227   PMID:7510577   PMID:7518474   PMID:7518475   PMID:7723623   PMID:7816096   PMID:7904155   PMID:7929101   PMID:7929904  
PMID:8015722   PMID:8036251   PMID:8061049   PMID:8180471   PMID:8267632   PMID:8595214   PMID:8601798   PMID:8699248   PMID:8742049   PMID:8756432   PMID:8840015   PMID:8965641  
PMID:8987814   PMID:8996814   PMID:9003035   PMID:9004271   PMID:9011744   PMID:9113374   PMID:9147327   PMID:9427357   PMID:9458051   PMID:9512392   PMID:9579645   PMID:9647694  
PMID:9712642   PMID:9718984   PMID:9768843   PMID:9822733   PMID:9892651   PMID:10349636   PMID:10479680   PMID:10694228   PMID:10727704   PMID:10767319   PMID:10771345   PMID:10862698  
PMID:10972963   PMID:10998114   PMID:11042159   PMID:11076861   PMID:11160454   PMID:11217851   PMID:11259776   PMID:11285019   PMID:11422443   PMID:11487658   PMID:11488959   PMID:11530236  
PMID:11719203   PMID:11897109   PMID:11897110   PMID:11920728   PMID:12008020   PMID:12103442   PMID:12147342   PMID:12191494   PMID:12191501   PMID:12391294   PMID:12427824   PMID:12467588  
PMID:12552130   PMID:12588844   PMID:12591944   PMID:12676993   PMID:12735629   PMID:12754515   PMID:12767483   PMID:12878694   PMID:12890763   PMID:12941447   PMID:14534245   PMID:14602821  
PMID:14622577   PMID:14645471   PMID:14750973   PMID:14985927   PMID:15003177   PMID:15066262   PMID:15317856   PMID:15385364   PMID:15496298   PMID:15519237   PMID:15537884   PMID:15590926  
PMID:15663482   PMID:15715677   PMID:15716419   PMID:15731593   PMID:15748150   PMID:15813953   PMID:16033900   PMID:16045501   PMID:16141072   PMID:16141073   PMID:16157280   PMID:16162920  
PMID:16189474   PMID:16190898   PMID:16207881   PMID:16221859   PMID:16332682   PMID:16356642   PMID:16427663   PMID:16438943   PMID:16452087   PMID:16554481   PMID:16602821   PMID:16710293  
PMID:16793155   PMID:16814779   PMID:16835771   PMID:16885526   PMID:16899073   PMID:16901514   PMID:16944113   PMID:16987237   PMID:17018287   PMID:17114649   PMID:17229826   PMID:17296552  
PMID:17329427   PMID:17350656   PMID:17548218   PMID:17803966   PMID:17804581   PMID:17879376   PMID:17898222   PMID:17901118   PMID:18054859   PMID:18077676   PMID:18082335   PMID:18197970  
PMID:18216203   PMID:18230672   PMID:18372311   PMID:18384166   PMID:18385321   PMID:18423999   PMID:18540994   PMID:18565157   PMID:18603407   PMID:18685090   PMID:18773961   PMID:18851757  
PMID:18945678   PMID:19208628   PMID:19240213   PMID:19243221   PMID:19276107   PMID:19298817   PMID:19332541   PMID:19439493   PMID:19455133   PMID:19474217   PMID:19605640   PMID:19726645  
PMID:19806658   PMID:19834457   PMID:19955431   PMID:20418887   PMID:20661302   PMID:20696923   PMID:20732897   PMID:20824214   PMID:20828614   PMID:20831617   PMID:20921396   PMID:20923697  
PMID:20936660   PMID:21060893   PMID:21106831   PMID:21185357   PMID:21190942   PMID:21267068   PMID:21297630   PMID:21503117   PMID:21521618   PMID:21558424   PMID:21664258   PMID:21677750  
PMID:21725314   PMID:21832195   PMID:21873635   PMID:21943605   PMID:21945132   PMID:21955919   PMID:22187052   PMID:22306487   PMID:22334046   PMID:22351628   PMID:22396402   PMID:22526419  
PMID:22565825   PMID:22572802   PMID:22723691   PMID:22794259   PMID:22855824   PMID:22933778   PMID:22956849   PMID:23118791   PMID:23123346   PMID:23201971   PMID:23259945   PMID:23557693  
PMID:23618906   PMID:23760271   PMID:23871830   PMID:23892010   PMID:23964123   PMID:24094580   PMID:24096375   PMID:24101472   PMID:24315834   PMID:24397780   PMID:24413569   PMID:24491550  
PMID:24554729   PMID:24739903   PMID:24834524   PMID:24893573   PMID:24908489   PMID:24952961   PMID:25059550   PMID:25083703   PMID:25131300   PMID:25360708   PMID:25392500   PMID:25645137  
PMID:25664912   PMID:25709106   PMID:25762721   PMID:25800971   PMID:25979088   PMID:26163108   PMID:26179233   PMID:26185009   PMID:26341484   PMID:26410354   PMID:26475861   PMID:26500840  
PMID:26609151   PMID:26627310   PMID:26679993   PMID:26793056   PMID:26880306   PMID:26929991   PMID:26969129   PMID:27015584   PMID:27212638   PMID:27317637   PMID:27457929   PMID:27480238  
PMID:27507650   PMID:27568567   PMID:27583186   PMID:27605622   PMID:27694970   PMID:27915379   PMID:28069946   PMID:28239767   PMID:28452394   PMID:28604739   PMID:28671696   PMID:28706196  
PMID:28713243   PMID:28864826   PMID:28865018   PMID:29024713   PMID:29138442   PMID:29176858   PMID:29459677   PMID:29488136   PMID:29593052   PMID:29748616   PMID:29754475   PMID:29764972  
PMID:30056832   PMID:30104731   PMID:30132892   PMID:30146685   PMID:30213765   PMID:30269991   PMID:30275542   PMID:30284099   PMID:30296532   PMID:30352630   PMID:30355491   PMID:30466882  
PMID:30696941   PMID:30710214   PMID:30946007   PMID:30973865   PMID:30992372   PMID:31085626   PMID:31125437   PMID:31167782   PMID:31196628   PMID:31498792   PMID:31570583   PMID:31577955  
PMID:31600191   PMID:31601771   PMID:31672961   PMID:31712124   PMID:31746486   PMID:31841517   PMID:31872888   PMID:31940483   PMID:32179753   PMID:32185508   PMID:32249816   PMID:32325033  
PMID:32499508   PMID:32577763   PMID:32581705   PMID:32726795   PMID:33158444   PMID:33420383   PMID:33661095   PMID:33781778   PMID:34058285   PMID:34197904   PMID:34455539   PMID:34588597  
PMID:34637854   PMID:35245678   PMID:35354047   PMID:35484243   PMID:35513389   PMID:35535852   PMID:35700736   PMID:35746896   PMID:35858542   PMID:36038077   PMID:36232696   PMID:36305367  
PMID:36417873   PMID:36604605   PMID:36914641   PMID:37142655   PMID:37657442   PMID:37709995   PMID:37723282   PMID:37736757   PMID:38355793   PMID:38380828   PMID:38471394   PMID:38569938  
PMID:38813758   PMID:39357737  


Genomics

Comparative Map Data
Grin2a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39169,385,765 - 9,813,744 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl169,385,762 - 9,813,424 (-)EnsemblGRCm39 Ensembl
GRCm38169,567,901 - 9,996,083 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl169,567,898 - 9,995,560 (-)EnsemblGRCm38mm10GRCm38
MGSCv37169,577,803 - 9,992,626 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36169,491,265 - 9,906,111 (-)NCBIMGSCv36mm8
Celera1610,217,398 - 10,625,063 (-)NCBICelera
Cytogenetic Map16A1NCBI
cM Map165.28NCBI
GRIN2A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38169,753,404 - 10,182,908 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl169,753,404 - 10,183,337 (-)EnsemblGRCh38hg38GRCh38
GRCh37169,847,261 - 10,276,765 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36169,762,923 - 10,184,112 (-)NCBINCBI36Build 36hg18NCBI36
Build 34169,762,922 - 10,184,112NCBI
Celera1610,014,039 - 10,444,548 (-)NCBICelera
Cytogenetic Map16p13.2NCBI
HuRef169,767,577 - 9,952,307 (-)NCBIHuRef
HuRef1610,193,124 - 10,195,907 (-)NCBIHuRef
CHM1_1169,847,229 - 10,277,115 (-)NCBICHM1_1
T2T-CHM13v2.0169,786,917 - 10,217,640 (-)NCBIT2T-CHM13v2.0
Grin2a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8106,136,458 - 6,560,003 (+)NCBIGRCr8
mRatBN7.2105,629,683 - 6,053,262 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl105,631,369 - 6,044,637 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1010,321,074 - 10,740,259 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0109,846,997 - 10,269,259 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0105,478,407 - 5,901,217 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0105,707,806 - 6,123,568 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl105,930,298 - 6,119,990 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0104,523,233 - 4,940,912 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4105,588,229 - 6,004,780 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1105,588,940 - 6,006,076 (+)NCBI
Celera104,645,710 - 5,048,399 (+)NCBICelera
Cytogenetic Map10q11NCBI
Grin2a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554428,174,232 - 8,562,059 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554428,171,114 - 8,565,187 (+)NCBIChiLan1.0ChiLan1.0
GRIN2A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21810,282,307 - 10,710,062 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11614,057,703 - 14,490,979 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0168,682,169 - 9,105,581 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1169,909,406 - 10,339,147 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl169,919,143 - 10,336,167 (-)Ensemblpanpan1.1panPan2
GRIN2A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1632,132,070 - 32,678,319 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl632,303,121 - 32,668,960 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha633,514,238 - 34,067,205 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0632,315,346 - 32,865,008 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl632,484,833 - 32,856,871 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1632,128,354 - 32,680,283 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0632,000,797 - 32,549,532 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0632,426,676 - 32,972,580 (+)NCBIUU_Cfam_GSD_1.0
Grin2a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344110,432,891 - 110,765,991 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365308,287,574 - 8,608,343 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365308,286,101 - 8,612,183 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GRIN2A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl332,750,700 - 33,143,499 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1332,749,329 - 33,149,350 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2333,810,701 - 33,913,481 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GRIN2A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.159,233,028 - 9,707,322 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl59,286,775 - 9,462,828 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606820,460,991 - 20,885,559 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Grin2a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248247,137,909 - 7,507,910 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248247,128,169 - 7,513,360 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Grin2a
13521 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:274
Count of miRNA genes:186
Interacting mature miRNAs:208
Transcripts:ENSMUST00000032331, ENSMUST00000115835, ENSMUST00000156482
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301970Heal11_mwound healing/regeneration 11 (mouse)Not determined16124263853Mouse
26884376Skwq4_mskull length QTL 4, 5 week (mouse)16841786490896888Mouse
4142460Nilac10_mnicotine induced locomotor activity 10 (mouse)Not determined16713690629225471Mouse
38501069Tip4_mtuberculosis immunophenotype 4, IFN-g level (mouse)16431786444520363Mouse
1302106Rapop1_mradiation-induced apoptosis 1 (mouse)Not determined16378077915731053Mouse
26884432Zlq7_mzygomatic length QTL 7, 10 week (mouse)16381786464620363Mouse
1300632Loca2_mlocomotor activity 2 (mouse)Not determined16122500574Mouse
1357658Dice1a_mdetermination of interleukin 4 commitment 1a (mouse)Not determined16780110010957706Mouse
27226768Tibl9_mtibia length 9, 5 week (mouse)16331786451420363Mouse
1301443Mopkd2_mmodifier of polycystic kidney disease progression 2 (mouse)Not determined16464631438646414Mouse
1301575Tanidd3_mtally ho associated non-insulin dependednt diabetes mellitus 3 (mouse)Not determined16122897739Mouse
1357763Lp1_mlymphocyte proliferation 1 (mouse)Not determined16654297965466552Mouse
1301384Dice1_mdetermination of interleukin 4 commitment 1 (mouse)Not determined16128434358Mouse
1300943Skts9_mskin tumor susceptibility 9 (mouse)Not determined16577525239775440Mouse
10402497Lmr23_mleishmaniasis resistance 23 (mouse)Not determined16129674200Mouse
10412289Ppsl_mplasma P-selectin levels (mouse)Not determined16130814572Mouse
4141468Nhdlq10_mnon-HDL QTL 10 (mouse)Not determined16124263853Mouse
1300656Bgeq15_mbody growth early QTL 15 (mouse)Not determined16577525239775440Mouse
1301559Bbaa19_mB.burgdorferi-associated arthritis 19 (mouse)Not determined16130066977Mouse
11251724Ewc6_methanol withdrawal and consumption 6 (mouse)16822605242226052Mouse
1300987Skull23_mskull morphology 23 (mouse)Not determined16577525239775440Mouse
1301945Skl7_mskeletal size (tail length) 7 (mouse)Not determined16577525239775440Mouse
4141010Bbq1_mbrain and behavior QTL 1 (mouse)Not determined16647700935021216Mouse
27095908Scvln7_msacral vertebrae length 2, 5 week (mouse)16331786439820362Mouse
4141060Pbwg19_mpostnatal body weight growth 19 (mouse)Not determined16120780888Mouse
10043879Adip25_madiposity 25 (mouse)Not determined16122520318Mouse
27226785Feml12_mfemur length 12, 5 week (mouse)16331786464620363Mouse

Markers in Region
D16Mit183  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38169,916,544 - 9,916,658UniSTSGRCm38
MGSCv37169,916,637 - 9,916,751UniSTSGRCm37
Celera1610,550,399 - 10,550,507UniSTS
Cytogenetic Map16A1UniSTS
cM Map168.0UniSTS
Whitehead Genetic167.7UniSTS
Whitehead_YAC16 UniSTS
D16Mit33  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38169,945,538 - 9,945,663UniSTSGRCm38
MGSCv37169,945,631 - 9,945,756UniSTSGRCm37
Celera1610,579,355 - 10,579,480UniSTS
Cytogenetic Map16A1UniSTS
cM Map164.8UniSTS
Whitehead Genetic168.7UniSTS
Whitehead/MRC_RH1665.18UniSTS
Whitehead_YAC16 UniSTS
D16Mit87  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38169,812,751 - 9,812,884UniSTSGRCm38
MGSCv37169,812,844 - 9,812,977UniSTSGRCm37
Celera1610,452,582 - 10,452,715UniSTS
Cytogenetic Map16A1UniSTS
cM Map164.75UniSTS
Whitehead Genetic167.7UniSTS
Whitehead/MRC_RH1665.08UniSTS
Whitehead_YAC16 UniSTS
UniSTS:224496  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38169,917,744 - 9,917,903UniSTSGRCm38
MGSCv37169,917,837 - 9,917,996UniSTSGRCm37
Celera1610,551,593 - 10,551,752UniSTS
Cytogenetic Map16A1UniSTS
cM Map163.4UniSTS
Grin2a  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38169,578,960 - 9,579,358UniSTSGRCm38
GRCm38856,953,523 - 56,953,921UniSTSGRCm38
MGSCv37169,577,958 - 9,578,182UniSTSGRCm37
MGSCv37859,433,589 - 59,433,813UniSTSGRCm37
Celera859,604,047 - 59,604,445UniSTS
Cytogenetic Map16A1UniSTS
Cytogenetic Map8B2UniSTS
cM Map163.4UniSTS
cM Map163.4UniSTS
ha3042  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38169,585,408 - 9,585,715UniSTSGRCm38
MGSCv37169,585,501 - 9,585,808UniSTSGRCm37
Celera1610,225,083 - 10,225,390UniSTS
Celera6139,069,596 - 139,070,459UniSTS
Cytogenetic Map16A1UniSTS
Cytogenetic Map6G1UniSTS
cM Map163.4UniSTS
cM Map664.5UniSTS
Grin2a  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38856,954,792 - 56,955,016UniSTSGRCm38
GRCm38169,577,865 - 9,578,089UniSTSGRCm38
MGSCv37859,433,589 - 59,433,813UniSTSGRCm37
MGSCv37169,577,958 - 9,578,182UniSTSGRCm37
Celera859,605,316 - 59,605,540UniSTS
Cytogenetic Map8B2UniSTS
Cytogenetic Map16A1UniSTS
cM Map163.4UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000032331   ⟹   ENSMUSP00000032331
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl169,395,691 - 9,810,397 (-)Ensembl
GRCm38.p6 Ensembl169,577,827 - 9,992,533 (-)Ensembl
Ensembl Acc Id: ENSMUST00000115835   ⟹   ENSMUSP00000111501
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl169,395,605 - 9,812,446 (-)Ensembl
GRCm38.p6 Ensembl169,577,741 - 9,994,582 (-)Ensembl
Ensembl Acc Id: ENSMUST00000156482
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl169,809,519 - 9,812,134 (-)Ensembl
GRCm38.p6 Ensembl169,991,655 - 9,994,270 (-)Ensembl
Ensembl Acc Id: ENSMUST00000197242
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl169,809,519 - 9,813,424 (-)Ensembl
GRCm38.p6 Ensembl169,991,655 - 9,995,560 (-)Ensembl
Ensembl Acc Id: ENSMUST00000199267
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl169,579,363 - 9,615,197 (-)Ensembl
GRCm38.p6 Ensembl169,761,499 - 9,797,333 (-)Ensembl
Ensembl Acc Id: ENSMUST00000199708   ⟹   ENSMUSP00000142900
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl169,385,762 - 9,812,787 (-)Ensembl
GRCm38.p6 Ensembl169,567,898 - 9,994,923 (-)Ensembl
RefSeq Acc Id: NM_008170   ⟹   NP_032196
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39169,385,765 - 9,813,677 (-)NCBI
GRCm38169,567,901 - 9,995,813 (-)NCBI
MGSCv37169,577,803 - 9,992,626 (-)RGD
Celera1610,217,398 - 10,625,063 (-)RGD
cM Map16 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006521795   ⟹   XP_006521858
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39169,439,139 - 9,813,744 (-)NCBI
GRCm38169,621,275 - 9,996,083 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_032196 (Get FASTA)   NCBI Sequence Viewer  
  XP_006521858 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAA01069 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000032331.7
  ENSMUSP00000111501.2
  ENSMUSP00000142900
  ENSMUSP00000142900.2
GenBank Protein P35436 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_032196   ⟸   NM_008170
- Peptide Label: precursor
- UniProtKB: P35436 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006521858   ⟸   XM_006521795
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSMUSP00000032331   ⟸   ENSMUST00000032331
Ensembl Acc Id: ENSMUSP00000142900   ⟸   ENSMUST00000199708
Ensembl Acc Id: ENSMUSP00000111501   ⟸   ENSMUST00000115835

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P35436-F1-model_v2 AlphaFold P35436 1-1464 view protein structure

Promoters
RGD ID:6827107
Promoter ID:MM_KWN:20066
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:NM_008170
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36169,992,421 - 9,993,072 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:95820 AgrOrtholog
Ensembl Genes ENSMUSG00000059003 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000032331.8 UniProtKB/Swiss-Prot
  ENSMUST00000115835.8 UniProtKB/Swiss-Prot
  ENSMUST00000199708 ENTREZGENE
  ENSMUST00000199708.5 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.2300 UniProtKB/Swiss-Prot
  Periplasmic binding protein-like II UniProtKB/Swiss-Prot
InterPro ANF_lig-bd_rcpt UniProtKB/Swiss-Prot
  Glu/Gly-bd UniProtKB/Swiss-Prot
  Iono_rcpt_met UniProtKB/Swiss-Prot
  Ionotropic_Glu_rcpt UniProtKB/Swiss-Prot
  Iontro_rcpt UniProtKB/Swiss-Prot
  NMDAR2_C UniProtKB/Swiss-Prot
  Peripla_BP_I UniProtKB/Swiss-Prot
KEGG Report mmu:14811 UniProtKB/Swiss-Prot
MGD MGI:95820 ENTREZGENE
NCBI Gene 14811 ENTREZGENE
PANTHER GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A UniProtKB/Swiss-Prot
  IONOTROPIC GLUTAMATE RECEPTOR UniProtKB/Swiss-Prot
Pfam ANF_receptor UniProtKB/Swiss-Prot
  Lig_chan UniProtKB/Swiss-Prot
  Lig_chan-Glu_bd UniProtKB/Swiss-Prot
  NMDAR2_C UniProtKB/Swiss-Prot
PhenoGen Grin2a PhenoGen
PRINTS NMDARECEPTOR UniProtKB/Swiss-Prot
SMART Lig_chan-Glu_bd UniProtKB/Swiss-Prot
  PBPe UniProtKB/Swiss-Prot
Superfamily-SCOP Periplasmic binding protein-like II UniProtKB/Swiss-Prot
  SSF53822 UniProtKB/Swiss-Prot
UniProt NMDE1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE