Fst (follistatin) - Rat Genome Database

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Gene: Fst (follistatin) Mus musculus
Analyze
Symbol: Fst
Name: follistatin
RGD ID: 10603
MGI Page MGI
Description: Predicted to enable activin binding activity; activin receptor antagonist activity; and heparan sulfate proteoglycan binding activity. Acts upstream of or within several processes, including BMP signaling pathway; hair follicle morphogenesis; and keratinocyte proliferation. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; brain; early conceptus; embryo mesenchyme; and genitourinary system. Used to study restrictive dermopathy. Human ortholog(s) of this gene implicated in polycystic ovary syndrome. Orthologous to human FST (follistatin).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: activin-binding protein; AL033346; D2Mgi5; FS
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3913114,588,798 - 114,595,522 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl13114,588,826 - 114,595,487 (-)EnsemblGRCm39 Ensembl
GRCm3813114,452,262 - 114,458,989 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl13114,452,290 - 114,458,951 (-)EnsemblGRCm38mm10GRCm38
MGSCv3713115,242,470 - 115,248,938 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3613115,574,219 - 115,579,464 (-)NCBIMGSCv36mm8
Celera13118,786,092 - 118,792,681 (-)NCBICelera
Cytogenetic Map13D2.2NCBI
cM Map1364.15NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1-Hydroxypyrene  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-Hydroxybenzo[a]pyrene  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (EXP)
3-Nitrobenzanthrone  (ISO)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (EXP)
5-aza-2'-deoxycytidine  (EXP,ISO)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
acetylsalicylic acid  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP,ISO)
ammonium chloride  (ISO)
antirheumatic drug  (ISO)
Archazolid B  (ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (ISO)
atrazine  (ISO)
azathioprine  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzo[k]fluoranthene  (EXP)
bis(2-chloroethyl) sulfide  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
buta-1,3-diene  (EXP)
butan-1-ol  (ISO)
butyric acid  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calciol  (EXP)
calcitriol  (ISO)
carbon nanotube  (EXP,ISO)
chloropicrin  (ISO)
chloroprene  (EXP)
chlorpyrifos  (EXP)
chromium(6+)  (EXP)
cisplatin  (ISO)
cobalt dichloride  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
corn oil  (EXP)
crocidolite asbestos  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
dextran sulfate  (EXP)
diarsenic trioxide  (ISO)
dibenzo[a,l]pyrene  (EXP)
dichloroacetic acid  (EXP)
dicrotophos  (ISO)
diethyl malate  (EXP)
diethylstilbestrol  (ISO)
dioxygen  (EXP,ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
entinostat  (ISO)
epoxiconazole  (EXP)
ethanol  (ISO)
fipronil  (ISO)
fluoranthene  (EXP)
formaldehyde  (ISO)
fulvestrant  (ISO)
furan  (EXP,ISO)
genistein  (ISO)
gentamycin  (ISO)
geraniol  (ISO)
GW 4064  (EXP)
hydralazine  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
inulin  (EXP)
isobutanol  (ISO)
isoflavones  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
methamphetamine  (ISO)
Methandrostenolone  (ISO)
methapyrilene  (ISO)
methotrexate  (EXP)
methoxychlor  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
Monobutylphthalate  (EXP)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (EXP)
N-Nitrosopyrrolidine  (ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (ISO)
nickel sulfate  (EXP)
O-methyleugenol  (ISO)
orphenadrine  (ISO)
oxaliplatin  (ISO)
oxybenzone  (ISO)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
pentobarbital  (ISO)
perfluorohexanesulfonic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
phenethyl isothiocyanate  (ISO)
phenobarbital  (EXP,ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
potassium iodide  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (EXP,ISO)
propiconazole  (EXP)
rac-lactic acid  (ISO)
raloxifene  (ISO)
ranitidine  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
sevoflurane  (ISO)
silicon dioxide  (ISO)
simvastatin  (EXP)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
sodium dodecyl sulfate  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP)
thioacetamide  (ISO)
titanium dioxide  (EXP)
topotecan  (ISO)
triadimefon  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
triptonide  (EXP)
troglitazone  (EXP,ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vancomycin  (EXP)
vitamin E  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal cervical rib  (IAGP)
abnormal extensor digitorum longus morphology  (IAGP)
abnormal gastrocnemius morphology  (IAGP)
abnormal muscle physiology  (IAGP)
abnormal neuron differentiation  (IAGP)
abnormal olfactory epithelium morphology  (IAGP)
abnormal olfactory sensory neuron morphology  (IAGP)
abnormal ovary morphology  (IAGP)
abnormal pectoral muscle morphology  (IAGP)
abnormal primordial ovarian follicle morphology  (IAGP)
abnormal retina neuronal layer morphology  (IAGP)
abnormal rib development  (IAGP)
abnormal skeletal muscle fiber morphology  (IAGP)
abnormal sternocostal joint morphology  (IAGP)
abnormal vibrissa morphology  (IAGP)
abnormal vitreous body morphology  (IEA)
absent hard palate  (IAGP)
absent lower incisors  (IAGP)
cleft secondary palate  (IAGP)
cyanosis  (IAGP)
decreased body weight  (IAGP)
decreased bone mineral density  (IEA)
decreased circulating testosterone level  (IAGP)
decreased corpora lutea number  (IAGP)
decreased fetal size  (IAGP)
decreased fetal weight  (IAGP)
decreased gastrocnemius weight  (IAGP)
decreased lean body mass  (IEA)
decreased litter size  (IAGP)
decreased lumbar vertebrae number  (IAGP)
decreased neuronal precursor cell number  (IAGP)
decreased quadriceps weight  (IAGP)
decreased rib number  (IAGP)
decreased skeletal muscle mass  (IAGP)
decreased skeletal muscle weight  (IAGP)
decreased superovulation rate  (IAGP)
decreased tertiary ovarian follicle number  (IAGP)
decreased thoracic vertebrae number  (IAGP)
early reproductive senescence  (IAGP)
female infertility  (IAGP)
fetal growth retardation  (IAGP)
growth retardation of incisors  (IAGP)
hyperkeratosis  (IAGP)
impaired fertilization  (IAGP)
increased atretic ovarian follicle number  (IAGP)
increased circulating follicle stimulating hormone level  (IAGP)
increased circulating luteinizing hormone level  (IAGP)
increased lumbar vertebrae number  (IAGP)
increased physiological sensitivity to xenobiotic  (IAGP)
increased primary ovarian follicle number  (IAGP)
increased retina ganglion cell number  (IAGP)
increased rib number  (IAGP)
increased secondary ovarian follicle number  (IAGP)
increased total body fat amount  (IEA)
neonatal lethality, complete penetrance  (IAGP)
ovary cyst  (IAGP)
ovary hemorrhage  (IAGP)
pallor  (IAGP)
persistence of hyaloid vascular system  (IEA)
preweaning lethality, complete penetrance  (IEA)
reduced female fertility  (IAGP)
respiratory failure  (IAGP)
shiny skin  (IAGP)
thick epidermis  (IAGP)
thin retina ganglion layer  (IAGP)
tight skin  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Multiple defects and perinatal death in mice deficient in follistatin. Matzuk MM, etal., Nature 1995 Mar 23;374(6520):360-3.
2. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. MGD IEA MGD IEA
5. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
8. Mouse MP Annotation Import Pipeline RGD automated import pipeline
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Thirty-seven candidate genes for polycystic ovary syndrome: strongest evidence for linkage is with follistatin. Urbanek M, etal., Proc Natl Acad Sci U S A. 1999 Jul 20;96(15):8573-8.
11. Expression of the activin axis and neuronal rescue effects of recombinant activin A following hypoxic-ischemic brain injury in the infant rat. Wu DD, etal., Brain Res. 1999 Jul 24;835(2):369-78. doi: 10.1016/s0006-8993(99)01638-8.
12. Lipopolysaccharide induced activin A-follistatin imbalance affects cardiac fibrosis. Zhang WQ, etal., Chin Med J (Engl). 2012 Jun;125(12):2205-12.
Additional References at PubMed
PMID:1330789   PMID:2106159   PMID:7600958   PMID:7619733   PMID:7671812   PMID:7821227   PMID:7848838   PMID:7956942   PMID:8649839   PMID:9256343   PMID:9326894   PMID:9440814  
PMID:9449667   PMID:9585504   PMID:9600941   PMID:9716414   PMID:9828086   PMID:10349636   PMID:10524628   PMID:10642791   PMID:10662633   PMID:10769089   PMID:10853830   PMID:11042159  
PMID:11076861   PMID:11217851   PMID:11298452   PMID:11459935   PMID:11557891   PMID:11574468   PMID:11739004   PMID:12117821   PMID:12203361   PMID:12477932   PMID:12514121   PMID:12546816  
PMID:12617826   PMID:12761853   PMID:12887271   PMID:14550793   PMID:14651926   PMID:14701941   PMID:14736745   PMID:14973287   PMID:15071597   PMID:15136138   PMID:15162500   PMID:15196959  
PMID:15277382   PMID:15289436   PMID:15305290   PMID:15451564   PMID:15525533   PMID:15533830   PMID:15944188   PMID:15944199   PMID:15963767   PMID:15976303   PMID:16103213   PMID:16109395  
PMID:16141072   PMID:16141073   PMID:16330189   PMID:16384867   PMID:16452457   PMID:16452715   PMID:16540514   PMID:16627583   PMID:16782087   PMID:17482756   PMID:17597062   PMID:17848526  
PMID:17878677   PMID:17881772   PMID:17911255   PMID:17932109   PMID:18047832   PMID:18077585   PMID:18155190   PMID:18184649   PMID:18250097   PMID:18250098   PMID:18287559   PMID:18436715  
PMID:18453534   PMID:18535106   PMID:18617533   PMID:18653563   PMID:18676373   PMID:18768463   PMID:18795097   PMID:18804092   PMID:18922734   PMID:18927154   PMID:18948405   PMID:18981061  
PMID:19079322   PMID:19106105   PMID:19168680   PMID:19268447   PMID:19297409   PMID:19435857   PMID:19457926   PMID:19474151   PMID:19538736   PMID:19715499   PMID:19864314   PMID:19884258  
PMID:20032047   PMID:20123092   PMID:20332189   PMID:20436479   PMID:20566686   PMID:20692344   PMID:20810712   PMID:21068065   PMID:21068158   PMID:21084447   PMID:21084449   PMID:21106872  
PMID:21267068   PMID:21402782   PMID:21416223   PMID:21546932   PMID:21576457   PMID:21654186   PMID:21677750   PMID:21689628   PMID:21852401   PMID:21873635   PMID:22138414   PMID:22311089  
PMID:22496664   PMID:22629441   PMID:22649074   PMID:22711699   PMID:22808246   PMID:22844512   PMID:22847922   PMID:22855279   PMID:23102581   PMID:23143061   PMID:23178301   PMID:23274689  
PMID:23300479   PMID:23533219   PMID:23541927   PMID:23684768   PMID:23769843   PMID:23840809   PMID:23987514   PMID:24006456   PMID:24019467   PMID:24344199   PMID:24443561   PMID:24449835  
PMID:24514266   PMID:24552588   PMID:24618599   PMID:24630125   PMID:24859004   PMID:24899573   PMID:25052838   PMID:25179606   PMID:25428587   PMID:25645944   PMID:25725066   PMID:25775517  
PMID:25827793   PMID:26878215   PMID:27571008   PMID:27793834   PMID:28118982   PMID:28205525   PMID:28235253   PMID:28324027   PMID:28363632   PMID:28426816   PMID:28467908   PMID:28471505  
PMID:28500669   PMID:28559342   PMID:28650075   PMID:28667125   PMID:28760667   PMID:28900034   PMID:29445148   PMID:29593116   PMID:29867232   PMID:30026265   PMID:30067986   PMID:30212841  
PMID:30995923   PMID:31184201   PMID:31187730   PMID:31242421   PMID:31427537   PMID:31488567   PMID:31492508   PMID:31712577   PMID:31836612   PMID:31850343   PMID:32243674   PMID:32301970  
PMID:32325033   PMID:32365547   PMID:32404924   PMID:32674056   PMID:33382037   PMID:33414188   PMID:33420269   PMID:33627800   PMID:33678425   PMID:34155146   PMID:34292881   PMID:34321999  
PMID:34385332   PMID:34544873   PMID:34851738   PMID:35084365   PMID:35148175   PMID:35306493   PMID:35704566   PMID:35831953   PMID:35974052   PMID:36305473   PMID:36411280   PMID:36497076  
PMID:36577057   PMID:36906067   PMID:37237002   PMID:37494420   PMID:37524711   PMID:38078651  


Genomics

Comparative Map Data
Fst
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3913114,588,798 - 114,595,522 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl13114,588,826 - 114,595,487 (-)EnsemblGRCm39 Ensembl
GRCm3813114,452,262 - 114,458,989 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl13114,452,290 - 114,458,951 (-)EnsemblGRCm38mm10GRCm38
MGSCv3713115,242,470 - 115,248,938 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3613115,574,219 - 115,579,464 (-)NCBIMGSCv36mm8
Celera13118,786,092 - 118,792,681 (-)NCBICelera
Cytogenetic Map13D2.2NCBI
cM Map1364.15NCBI
FST
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38553,480,629 - 53,487,134 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl553,480,626 - 53,487,134 (+)EnsemblGRCh38hg38GRCh38
GRCh37552,776,459 - 52,782,964 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36552,812,352 - 52,817,680 (+)NCBINCBI36Build 36hg18NCBI36
Build 34552,812,351 - 52,817,659NCBI
Celera549,730,217 - 49,735,545 (+)NCBICelera
Cytogenetic Map5q11.2NCBI
HuRef549,748,385 - 49,754,428 (+)NCBIHuRef
CHM1_1552,779,193 - 52,785,231 (+)NCBICHM1_1
T2T-CHM13v2.0554,308,436 - 54,314,946 (+)NCBIT2T-CHM13v2.0
Fst
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8247,856,345 - 47,863,670 (-)NCBIGRCr8
mRatBN7.2246,123,260 - 46,130,584 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl246,123,439 - 46,130,571 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx253,226,536 - 53,233,459 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0251,284,901 - 51,291,822 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0246,164,805 - 46,171,742 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0246,537,589 - 46,544,813 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl246,538,700 - 46,544,457 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0265,576,721 - 65,583,918 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4246,542,246 - 46,550,678 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1246,470,478 - 46,478,911 (-)NCBI
Celera241,883,386 - 41,889,989 (-)NCBICelera
Cytogenetic Map2q14NCBI
Fst
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544613,925,776 - 13,932,104 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544613,925,833 - 13,932,104 (-)NCBIChiLan1.0ChiLan1.0
FST
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2460,454,897 - 60,462,481 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1558,608,522 - 58,616,019 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0560,544,495 - 60,550,516 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1562,163,655 - 62,168,218 (-)NCBIpanpan1.1PanPan1.1panPan2
FST
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1461,779,252 - 61,785,666 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl461,779,259 - 61,783,260 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha461,544,683 - 61,551,112 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0462,270,843 - 62,277,297 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl462,271,936 - 62,277,253 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1462,049,664 - 62,056,089 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0462,178,184 - 62,184,600 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0462,695,162 - 62,701,588 (-)NCBIUU_Cfam_GSD_1.0
Fst
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213205,054,434 - 205,060,754 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648013,990,929 - 13,997,248 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648013,990,967 - 13,997,248 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FST
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1632,805,932 - 32,811,421 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11632,806,341 - 32,811,382 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21634,779,040 - 34,784,066 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FST
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1449,773,646 - 49,780,343 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl449,773,980 - 49,780,333 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660821,343,148 - 1,349,927 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fst
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247595,798,067 - 5,805,254 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247595,799,127 - 5,804,802 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fst
181 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:414
Count of miRNA genes:274
Interacting mature miRNAs:330
Transcripts:ENSMUST00000022287
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142334Svtms_msurvival time modifier of Sod2 (mouse)Not determined13107613580119476372Mouse
1558741Ses10_msalmonella enteritidis susceptibility 10 (mouse)Not determined1382739968116740106Mouse
1301142Heal2_mwound healing/regeneration 2 (mouse)Not determined1393875267120883175Mouse
1357468Rplag_mreduced platelet aggregation (mouse)Not determined1395502130120883175Mouse
12879496Fexq2_mfear expression QTL 2 (mouse)13100741519120883175Mouse
14700691Cisaq1_mcoxsackieviral infection serum ALT QTL 1 (mouse)1386148119120461536Mouse
4141704Hipq1_mhyperinsulin production QTL 1 (mouse)Not determined110409487119476372Mouse
1300939Hrtfm6_mheart failure modifier 6 (mouse)Not determined1391383692120883175Mouse
4140995Fbtq6_mfemoral bone trait QTL 6 (mouse)Not determined1386341617120341758Mouse
1558763Gct9_mgranulosa cell tumorigenesis 9 (mouse)Not determined1395036824120883175Mouse
4142338Skmw18_mskeletal muscle weight 18 (mouse)Not determined1394528399120883175Mouse
4141826Tbqt5_mtibia bone quality traits 5 (mouse)Not determined13103341617117043216Mouse
4142465Pbwg17_mpostnatal body weight growth 17 (mouse)Not determined1383876060117876256Mouse
1300876Tanidd2_mtally ho associated non-insulin dependednt diabetes mellitus 2 (mouse)Not determined1391965303120883175Mouse
14746974Manh75_mmandible shape 75 (mouse)1399386647120883175Mouse
4142400Tgq24_mtriglyceride QTL 24 (mouse)Not determined102602630120883175Mouse

Markers in Region
Fst  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3813114,455,203 - 114,455,322UniSTSGRCm38
MGSCv3713115,245,411 - 115,245,530UniSTSGRCm37
Celera13118,789,033 - 118,789,152UniSTS
Cytogenetic Map13D2.2UniSTS
cM MapUN UniSTS
cM Map13 UniSTS
Fst  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map13D2.2UniSTS
cM MapUN UniSTS
cM Map13 UniSTS
Fst  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3813114,452,576 - 114,452,723UniSTSGRCm38
MGSCv3713115,242,784 - 115,242,931UniSTSGRCm37
Celera13118,786,406 - 118,786,553UniSTS
Cytogenetic Map13D2.2UniSTS
Fst  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3813114,454,366 - 114,455,813UniSTSGRCm38
MGSCv3713115,244,574 - 115,246,021UniSTSGRCm37
Celera13118,788,196 - 118,789,643UniSTS
Cytogenetic Map13D2.2UniSTS


Expression


Sequence


RefSeq Acc Id: ENSMUST00000022287   ⟹   ENSMUSP00000022287
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl13114,589,506 - 114,595,485 (-)Ensembl
GRCm38.p6 Ensembl13114,452,970 - 114,458,949 (-)Ensembl
RefSeq Acc Id: ENSMUST00000223640   ⟹   ENSMUSP00000153365
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl13114,588,826 - 114,595,487 (-)Ensembl
GRCm38.p6 Ensembl13114,452,290 - 114,458,951 (-)Ensembl
RefSeq Acc Id: ENSMUST00000223865
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl13114,589,641 - 114,591,087 (-)Ensembl
GRCm38.p6 Ensembl13114,453,105 - 114,454,551 (-)Ensembl
RefSeq Acc Id: ENSMUST00000225068   ⟹   ENSMUSP00000153451
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl13114,590,245 - 114,591,746 (-)Ensembl
GRCm38.p6 Ensembl13114,453,709 - 114,455,210 (-)Ensembl
RefSeq Acc Id: ENSMUST00000231252   ⟹   ENSMUSP00000156375
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl13114,589,878 - 114,595,122 (-)Ensembl
GRCm38.p6 Ensembl13114,453,342 - 114,458,586 (-)Ensembl
RefSeq Acc Id: ENSMUST00000231498
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl13114,589,852 - 114,592,772 (-)Ensembl
GRCm38.p6 Ensembl13114,453,316 - 114,456,236 (-)Ensembl
RefSeq Acc Id: NM_001301373   ⟹   NP_001288302
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3913114,588,798 - 114,595,487 (-)NCBI
GRCm3813114,452,262 - 114,458,951 (-)NCBI
Celera13118,786,092 - 118,792,903 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001301375   ⟹   NP_001288304
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3913114,588,798 - 114,595,487 (-)NCBI
GRCm3813114,452,262 - 114,458,951 (-)NCBI
Celera13118,786,092 - 118,792,903 (-)NCBI
Sequence:
RefSeq Acc Id: NM_008046   ⟹   NP_032072
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3913114,588,798 - 114,595,487 (-)NCBI
GRCm3813114,452,262 - 114,458,951 (-)NCBI
MGSCv3713115,242,470 - 115,248,938 (-)RGD
Celera13118,786,092 - 118,792,903 (-)NCBI
cM Map13 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_030247150   ⟹   XP_030103010
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3913114,588,798 - 114,595,522 (-)NCBI
GRCm3813114,452,262 - 114,458,989 (-)NCBI
Sequence:
RefSeq Acc Id: NP_032072   ⟸   NM_008046
- Peptide Label: isoform 2 precursor
- UniProtKB: P47931 (UniProtKB/Swiss-Prot),   Q8BNY0 (UniProtKB/TrEMBL),   A0A0R4J026 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001288302   ⟸   NM_001301373
- Peptide Label: isoform FST315 precursor
- UniProtKB: A6H6P0 (UniProtKB/Swiss-Prot),   P47931 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001288304   ⟸   NM_001301375
- Peptide Label: isoform FST288 precursor
- UniProtKB: Q8BNY0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_030103010   ⟸   XM_030247150
- Peptide Label: isoform X1
RefSeq Acc Id: ENSMUSP00000153365   ⟸   ENSMUST00000223640
RefSeq Acc Id: ENSMUSP00000156375   ⟸   ENSMUST00000231252
RefSeq Acc Id: ENSMUSP00000153451   ⟸   ENSMUST00000225068
RefSeq Acc Id: ENSMUSP00000022287   ⟸   ENSMUST00000022287
Protein Domains
Follistatin-like   Kazal-like   TB

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P47931-F1-model_v2 AlphaFold P47931 1-344 view protein structure

Promoters
RGD ID:8681350
Promoter ID:EPDNEW_M18705
Type:single initiation site
Name:Fst_2
Description:Mus musculus follistatin , transcript variant 3, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M18706  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3813114,458,727 - 114,458,787EPDNEW
RGD ID:8681352
Promoter ID:EPDNEW_M18706
Type:multiple initiation site
Name:Fst_1
Description:Mus musculus follistatin , transcript variant 3, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M18705  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3813114,458,951 - 114,459,011EPDNEW
RGD ID:6847031
Promoter ID:MM_ACW:14686
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   MEF_B6
Transcripts:FST.DSEP07,   FST.ESEP07-UNSPLICED,   FST.FSEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3613115,246,801 - 115,247,392 (-)MPROMDB
RGD ID:6823913
Promoter ID:MM_KWN:15321
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   BoneMarrow_4Hour,   MEF_B4
Transcripts:NM_008046,   UC007RXO.1,   UC007RXP.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3613115,248,556 - 115,249,082 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:95586 AgrOrtholog
Ensembl Genes ENSMUSG00000021765 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000022287 ENTREZGENE
  ENSMUST00000022287.8 UniProtKB/Swiss-Prot
  ENSMUST00000223640 ENTREZGENE
  ENSMUST00000223640.3 UniProtKB/TrEMBL
  ENSMUST00000225068.2 UniProtKB/TrEMBL
  ENSMUST00000231252 ENTREZGENE
  ENSMUST00000231252.2 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.60.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.90.290.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Fol_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Follistatin/Osteonectin_EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kazal_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kazal_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TB_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TB_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:14313 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:95586 ENTREZGENE
NCBI Gene 14313 ENTREZGENE
PANTHER AGRIN UniProtKB/Swiss-Prot
  FOLLISTATIN UniProtKB/TrEMBL
  FOLLISTATIN-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam FOLN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FST_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kazal_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Fst PhenoGen
PROSITE KAZAL_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PS51364 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART FOLN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KAZAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF100895 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57581 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0R4J026 ENTREZGENE
  A0A286YDK1_MOUSE UniProtKB/TrEMBL
  A6H6P0 ENTREZGENE
  FST_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q8BNY0 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A6H6P0 UniProtKB/Swiss-Prot