Fgfr2 (fibroblast growth factor receptor 2) - Rat Genome Database

Send us a Message

Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Fgfr2 (fibroblast growth factor receptor 2) Mus musculus
Symbol: Fgfr2
Name: fibroblast growth factor receptor 2
RGD ID: 10581
Description: Enables fibroblast growth factor binding activity. Involved in several processes, including fibroblast growth factor receptor signaling pathway; forebrain generation of neurons; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including lung development; morphogenesis of an epithelium; and positive regulation of cell population proliferation. Located in excitatory synapse and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; limb; and sensory organ. Used to study Beare-Stevenson cutis gyrata syndrome; atopic dermatitis; intestinal atresia; and synostosis (multiple). Human ortholog(s) of this gene implicated in several diseases, including Beare-Stevenson cutis gyrata syndrome; breast cancer (multiple); gastrointestinal system cancer (multiple); reproductive organ cancer (multiple); and synostosis (multiple). Orthologous to human FGFR2 (fibroblast growth factor receptor 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AU043015; AW556123; Bek; Fgfr; Fgfr-; Fgfr-2; Fgfr-7; Fgfr2b; Fgfr7; keratinocyte growth factor receptor; KGFR; KGFRTr; MGC102519; svs
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm397129,764,181 - 129,868,538 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7129,764,181 - 132,725,079 (-)EnsemblGRCm39 Ensembl
GRCm387130,162,451 - 130,266,808 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7130,162,451 - 133,123,350 (-)EnsemblGRCm38mm10GRCm38
MGSCv377137,305,965 - 137,410,322 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367129,954,867 - 130,057,411 (-)NCBIMGSCv36mm8
Celera7129,989,855 - 130,093,942 (-)NCBICelera
Cytogenetic Map7F3NCBI
cM Map773.19NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
Acneiform Eruptions  (ISO)
acrocephalosyndactylia  (IAGP,IMP,ISO)
adenoid cystic carcinoma  (ISO)
ankylosis  (ISO)
Anorectal Malformations  (ISO)
Antley-Bixler syndrome  (ISO)
Antley-Bixler syndrome with disordered steroidogenesis  (ISO)
Antley-Bixler syndrome without disordered steroidogenesis  (ISO)
atherosclerosis  (IDA)
Beare-Stevenson cutis gyrata syndrome  (IAGP,ISO)
Bent Bone Dysplasia Syndrome 1  (ISO)
breast cancer  (IMP,ISO)
Breast Neoplasms  (ISO)
Chemical Burns  (ISO)
cholangiocarcinoma  (ISO)
cleft lip  (ISO)
cleft palate  (ISO)
colorectal adenocarcinoma  (ISO)
colorectal cancer  (ISO)
Congenital Aural Atresia  (ISO)
Congenital Limb Deformities  (ISO)
Craniofacial Abnormalities  (IMP,ISO)
craniosynostosis  (IMP,ISO)
Craniosynostosis Syndrome, Autosomal Recessive  (ISO)
Crouzon syndrome  (IAGP,ISO)
developmental coordination disorder  (ISO)
disorder of sexual development  (ISO)
duodenal atresia  (IMP)
dysgerminoma  (ISO)
endometrial carcinoma  (ISO)
Endometrial Neoplasms  (ISO)
Endometrioid Carcinomas  (ISO)
endometriosis  (ISO)
Epstein-Barr virus infectious disease  (ISO)
esophageal carcinoma  (ISO)
essential hypertension  (ISO)
female breast carcinoma  (ISO)
gastric adenocarcinoma  (ISO)
genetic disease  (ISO)
head and neck cancer  (ISO)
Head and Neck Neoplasms  (ISO)
hepatocellular carcinoma  (ISO)
Hypertelorism  (ISO)
hypospadias  (ISO)
intellectual disability  (ISO)
interstitial lung disease 2  (ISO)
intestinal atresia  (IAGP)
Jackson-Weiss syndrome  (ISO)
Kaposi's sarcoma  (ISO)
Kidney Reperfusion Injury  (IEP,IMP,ISO)
lacrimoauriculodentodigital syndrome 1  (ISO)
LADD syndrome  (ISO)
Left Ventricular Hypertrophy  (IMP)
Leg Ulcer  (ISO)
liver cirrhosis  (ISO)
lung adenocarcinoma  (ISO)
Lung Neoplasms  (ISO)
Lung Reperfusion Injury  (ISO)
lung squamous cell carcinoma  (ISO)
Lymphatic Metastasis  (ISO)
Multiple Abnormalities  (ISO)
myocardial infarction  (IMP)
Nasopharyngeal Neoplasms  (ISO)
Ovarian Neoplasms  (ISO)
Pfeiffer syndrome  (IAGP,ISO)
Plagiocephaly, Nonsynostotic  (ISO)
Plaque, Atherosclerotic  (ISO)
portal hypertension  (ISO)
primary pulmonary hypertension  (ISO)
prostate cancer  (ISO)
prostate carcinoma in situ  (IMP)
PTEN hamartoma tumor syndrome  (ISO)
retinitis pigmentosa  (ISO)
Saethre-Chotzen syndrome  (ISO)
Scaphocephaly, Maxillary Retrusion, and Impaired Intellectual Development  (ISO)
sensorineural hearing loss  (ISO)
Skin Abnormalities  (ISO)
skin disease  (ISO)
spina bifida  (ISO)
Spinal Cord Compression  (ISO)
split hand-foot malformation  (ISO)
squamous cell carcinoma  (ISO)
stomach cancer  (ISO)
stomach carcinoma  (ISO)
Stomach Neoplasms  (ISO)
Tooth Abnormalities  (ISO)
Tracheoesophageal Fistula  (ISO)
transient cerebral ischemia  (ISO)
transitional cell carcinoma  (ISO)
umbilical hernia  (IMP)
urinary bladder cancer  (ISO)
uterine cancer  (ISO)
uterine carcinosarcoma  (ISO)
Uterine Cervical Neoplasms  (ISO)
ventricular septal defect  (IMP)
viral pneumonia  (IEP,IMP)
Volvulus Of Midgut  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
1-(5-isoquinolinesulfonyl)-2-methylpiperazine  (ISO)
1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5-triiodo-L-thyronine  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
3-methylcholanthrene  (EXP)
3-Nitrobenzanthrone  (ISO)
3-phenylprop-2-enal  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (EXP)
5-(2-methylpiperazine-1-sulfonyl)isoquinoline  (ISO)
5-aza-2'-deoxycytidine  (EXP)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
acetone  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (ISO)
ammonium chloride  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
AZD4547  (ISO)
benzene  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bifenthrin  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
buspirone  (ISO)
Butylbenzyl phthalate  (ISO)
Butylparaben  (ISO)
cadmium atom  (EXP,ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
carbon nanotube  (EXP,ISO)
carbonyl sulfide  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (EXP,ISO)
cisplatin  (ISO)
clofibrate  (EXP)
colforsin daropate hydrochloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cordycepin  (EXP,ISO)
crocidolite asbestos  (ISO)
cumene hydroperoxide  (EXP)
Cuprizon  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
cyhalothrin  (ISO)
decabromodiphenyl ether  (ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
diazepam  (ISO)
dibutyl phthalate  (ISO)
diethyl malate  (EXP)
dioxygen  (EXP)
dipentyl phthalate  (ISO)
disodium selenite  (EXP)
doxorubicin  (ISO)
endosulfan  (ISO)
enzacamene  (ISO)
ethanol  (EXP,ISO)
flavonoids  (ISO)
fluprostenol  (ISO)
fluvalinate  (ISO)
genistein  (ISO)
gentamycin  (ISO)
heparan sulfate  (ISO)
heparin  (EXP,ISO)
hydrogen peroxide  (EXP,ISO)
indole-3-methanol  (ISO)
inulin  (EXP)
lenalidomide  (ISO)
linuron  (ISO)
manganese(II) chloride  (ISO)
menadione  (ISO)
mercury dibromide  (ISO)
methoxychlor  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
mifepristone  (ISO)
monosodium L-glutamate  (EXP)
N,N-diethyl-m-toluamide  (ISO)
N-(1-naphthyl)ethylenediamine  (EXP)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (EXP)
nefazodone  (ISO)
Neferine  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
nitrofen  (ISO)
nitroglycerin  (ISO)
O-methyleugenol  (ISO)
oxaliplatin  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
pentane-2,3-dione  (ISO)
perfluorohexanesulfonic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
permethrin  (ISO)
phenobarbital  (EXP)
phenytoin  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
pirinixic acid  (EXP,ISO)
ponatinib  (ISO)
potassium dichromate  (EXP)
progesterone  (EXP,ISO)
prostaglandin F2alpha  (ISO)
raloxifene  (ISO)
reactive oxygen species  (EXP)
Rebamipide  (ISO)
silicon dioxide  (ISO)
sodium dichromate  (EXP)
sucrose octasulfate  (ISO)
suramin  (ISO)
tamoxifen  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
thalidomide  (ISO)
thimerosal  (ISO)
thioacetamide  (ISO)
tipifarnib  (ISO)
topotecan  (ISO)
trichloroethene  (ISO)
trimellitic anhydride  (EXP)
triptonide  (EXP)
troglitazone  (EXP)
valproic acid  (ISO)
vanadyl sulfate  (ISO)
vanillin  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (IGI)
animal organ morphogenesis  (IMP)
apoptotic process  (IEA)
axonogenesis  (IMP)
bone development  (IMP)
bone mineralization  (IMP)
bone morphogenesis  (IMP)
branch elongation involved in salivary gland morphogenesis  (IGI,IMP)
branching involved in labyrinthine layer morphogenesis  (IMP)
branching involved in prostate gland morphogenesis  (IMP)
branching involved in salivary gland morphogenesis  (IMP)
branching morphogenesis of a nerve  (IMP)
bud elongation involved in lung branching  (IMP)
canonical Wnt signaling pathway  (IGI)
cardiac muscle cell proliferation  (IGI)
cell division  (IMP)
cell fate commitment  (IDA,IMP)
cell population proliferation  (IGI,IMP)
cell surface receptor protein tyrosine kinase signaling pathway  (IBA)
cell-cell signaling  (IMP)
cellular response to fibroblast growth factor stimulus  (ISO)
cellular response to hypoxia  (ISO)
cellular response to retinoic acid  (ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
coronal suture morphogenesis  (IMP)
digestive tract development  (IMP)
embryonic cranial skeleton morphogenesis  (ISO)
embryonic digestive tract morphogenesis  (IMP)
embryonic organ development  (IMP)
embryonic organ morphogenesis  (IMP)
embryonic pattern specification  (IMP)
endochondral bone growth  (ISO)
endodermal digestive tract morphogenesis  (IMP)
epidermis morphogenesis  (IMP)
epithelial cell differentiation  (IMP)
epithelial cell proliferation  (IGI,IMP)
epithelial cell proliferation involved in salivary gland morphogenesis  (IGI,IMP)
epithelial to mesenchymal transition  (ISO)
epithelial tube branching involved in lung morphogenesis  (IMP)
ERK1 and ERK2 cascade  (IGI)
fibroblast growth factor receptor apoptotic signaling pathway  (IMP)
fibroblast growth factor receptor signaling pathway  (IGI,IMP,ISO)
fibroblast growth factor receptor signaling pathway involved in hemopoiesis  (IMP)
fibroblast growth factor receptor signaling pathway involved in mammary gland specification  (IMP)
fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow cell  (IMP)
fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development  (IMP)
fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow  (IMP)
gland morphogenesis  (IMP)
hair follicle morphogenesis  (IMP)
in utero embryonic development  (IGI,IMP)
inner ear morphogenesis  (IMP)
lacrimal gland development  (IMP)
lateral sprouting from an epithelium  (IMP)
lens fiber cell development  (IGI,IMP)
limb bud formation  (IMP)
lung alveolus development  (IGI,IMP)
lung development  (IGI,IMP)
lung lobe morphogenesis  (IMP)
lung-associated mesenchyme development  (IGI,IMP)
mammary gland bud formation  (IMP)
membranous septum morphogenesis  (IMP)
mesenchymal cell differentiation  (IGI)
mesenchymal cell differentiation involved in lung development  (IGI)
mesenchymal cell proliferation  (IGI)
mesenchymal cell proliferation involved in lung development  (IMP)
mesodermal cell differentiation  (ISO)
midbrain development  (IGI)
mitotic nuclear division  (IGI)
morphogenesis of embryonic epithelium  (IMP)
negative regulation of epithelial cell proliferation  (IGI,ISO)
negative regulation of keratinocyte proliferation  (ISO)
negative regulation of mitotic nuclear division  (IGI)
negative regulation of transcription by RNA polymerase II  (IMP)
neuromuscular junction development  (IMP)
odontogenesis  (IMP)
orbitofrontal cortex development  (IMP)
organ growth  (IMP)
otic vesicle formation  (IMP,TAS)
outflow tract septum morphogenesis  (IMP)
positive regulation of canonical Wnt signaling pathway  (IGI,IMP)
positive regulation of cardiac muscle cell proliferation  (IGI)
positive regulation of cell cycle  (IMP)
positive regulation of cell division  (IMP)
positive regulation of cell population proliferation  (IGI,IMP,ISO)
positive regulation of epithelial cell proliferation  (IGI,IMP)
positive regulation of epithelial cell proliferation involved in lung morphogenesis  (IMP)
positive regulation of ERK1 and ERK2 cascade  (IGI)
positive regulation of gene expression  (IMP)
positive regulation of MAPK cascade  (ISO)
positive regulation of mesenchymal cell proliferation  (IGI)
positive regulation of stem cell proliferation  (IGI,IMP)
positive regulation of transcription by RNA polymerase II  (IMP)
positive regulation of urothelial cell proliferation  (IMP)
positive regulation of vascular associated smooth muscle cell proliferation  (ISO)
positive regulation of Wnt signaling pathway  (IMP)
post-embryonic development  (IMP)
prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis  (IMP)
prostate epithelial cord elongation  (IMP)
prostate gland morphogenesis  (IMP)
pyramidal neuron development  (IMP)
regulation of epithelial cell proliferation  (IMP)
regulation of ERK1 and ERK2 cascade  (IMP)
regulation of morphogenesis of a branching structure  (IMP)
regulation of osteoblast proliferation  (IMP)
regulation of smooth muscle cell differentiation  (IMP)
regulation of smoothened signaling pathway  (IMP)
reproductive structure development  (IMP)
response to ethanol  (ISO)
response to lipopolysaccharide  (ISO)
squamous basal epithelial stem cell differentiation involved in prostate gland acinus development  (IMP)
stem cell differentiation  (IGI)
stem cell proliferation  (IGI,IMP)
synaptic vesicle transport  (IMP)
ureteric bud development  (IGI)
urothelial cell proliferation  (IMP)
vasculogenesis involved in coronary vascular morphogenesis  (TAS)
ventricular cardiac muscle tissue morphogenesis  (IMP)
ventricular zone neuroblast division  (IMP)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal adrenal gland development  (IAGP)
abnormal apical ectodermal ridge morphology  (IAGP)
abnormal appendicular skeleton morphology  (IAGP)
abnormal astrocyte morphology  (IAGP)
abnormal axial skeleton morphology  (IAGP)
abnormal basicranium morphology  (IAGP)
abnormal basioccipital bone morphology  (IAGP)
abnormal basisphenoid bone morphology  (IAGP)
abnormal bone ossification  (IAGP)
abnormal brain morphology  (IAGP)
abnormal brain size  (IAGP)
abnormal branching involved in seminal vesicle morphogenesis  (IAGP)
abnormal bronchiole morphology  (IAGP)
abnormal cartilage development  (IAGP)
abnormal cartilage morphology  (IAGP)
abnormal cecum development  (IAGP)
abnormal cerebral hemisphere morphology  (IAGP)
abnormal cervical vertebrae morphology  (IAGP)
abnormal chemokine level  (IAGP)
abnormal chondrocyte morphology  (IAGP)
abnormal clavicle morphology  (IAGP)
abnormal coat/ hair morphology  (IAGP)
abnormal cochlea morphology  (IAGP)
abnormal cochlear sensory epithelium morphology  (IAGP)
abnormal conotruncal ridge morphology  (IAGP)
abnormal coronal suture morphology  (IAGP)
abnormal corpus callosum morphology  (IAGP)
abnormal cranial cartilage development  (IAGP)
abnormal cranial cartilage morphology  (IAGP)
abnormal cranial cavity morphology  (IAGP)
abnormal cranial suture morphology  (IAGP)
abnormal cranial synchondrosis  (IAGP)
abnormal craniofacial bone morphology  (IAGP)
abnormal craniofacial morphology  (IAGP)
abnormal cranium morphology  (IAGP)
abnormal decidualization  (IAGP)
abnormal dermis papillary layer morphology  (IAGP)
abnormal developmental patterning  (IAGP)
abnormal digestive system morphology  (IAGP)
abnormal digestive system physiology  (IAGP)
abnormal ear development  (IAGP)
abnormal egg cylinder morphology  (IAGP)
abnormal embryo development  (IAGP)
abnormal endochondral bone ossification  (IAGP)
abnormal endoderm development  (IAGP)
abnormal endolymphatic duct morphology  (IAGP)
abnormal epidermal layer morphology  (IAGP)
abnormal epidermis stratum basale morphology  (IAGP)
abnormal epidermis stratum corneum morphology  (IAGP)
abnormal epidermis stratum granulosum morphology  (IAGP)
abnormal facial morphology  (IAGP)
abnormal frontal bone morphology  (IAGP)
abnormal hair cycle  (IAGP)
abnormal hair follicle development  (IAGP)
abnormal hair follicle morphology  (IAGP)
abnormal hair follicle orientation  (IAGP)
abnormal head morphology  (IAGP)
abnormal head shape  (IAGP)
abnormal heart development  (IAGP)
abnormal heart ventricle morphology  (IAGP)
abnormal ilium morphology  (IAGP)
abnormal intermaxillary suture morphology  (IAGP)
abnormal interparietal bone morphology  (IAGP)
abnormal interventricular groove morphology  (IAGP)
abnormal intestinal glucose absorption  (IAGP)
abnormal ischium morphology  (IAGP)
abnormal joint morphology  (IAGP)
abnormal keratinocyte morphology  (IAGP)
abnormal kidney cortex morphology  (IAGP)
abnormal kidney development  (IAGP)
abnormal lacrimal gland development  (IAGP)
abnormal lambdoid suture morphology  (IAGP)
abnormal lateral ganglionic eminence morphology  (IAGP)
abnormal lateral nasal gland morphology  (IAGP)
abnormal limb development  (IAGP)
abnormal liver development  (IAGP)
abnormal long bone epiphyseal ossification zone morphology  (IAGP)
abnormal long bone epiphyseal plate proliferative zone  (IAGP)
abnormal long bone epiphysis morphology  (IAGP)
abnormal long bone hypertrophic chondrocyte zone  (IAGP)
abnormal long bone metaphysis morphology  (IAGP)
abnormal lung development  (IAGP)
abnormal lung morphology  (IAGP)
abnormal mammary gland bud morphology  (IAGP)
abnormal mammary placode morphology  (IAGP)
abnormal mandible morphology  (IAGP)
abnormal mandibular angle morphology  (IAGP)
abnormal mast cell morphology  (IAGP)
abnormal maxillary frontal process morphology  (IAGP)
abnormal maxillary zygomatic process morphology  (IAGP)
abnormal maxillary-premaxillary suture morphology  (IAGP)
abnormal medial ganglionic eminence morphology  (IAGP)
abnormal membranous labyrinth morphology  (IAGP)
abnormal metanephric mesenchyme morphology  (IAGP)
abnormal midface morphology  (IAGP)
abnormal nail morphology  (IAGP)
abnormal nasal bone morphology  (IAGP)
abnormal nasal capsule morphology  (IAGP)
abnormal nasal gland morphology  (IAGP)
abnormal nasal septum cartilage morphology  (IAGP)
abnormal nasomaxillary suture morphology  (IAGP)
abnormal neurocranium morphology  (IAGP)
abnormal osteoblast differentiation  (IAGP)
abnormal osteoblast physiology  (IAGP)
abnormal osteoblast proliferation  (IAGP)
abnormal osteoclast differentiation  (IAGP)
abnormal otic capsule morphology  (IAGP)
abnormal otic vesicle development  (IAGP)
abnormal palatal mesenchymal cell proliferation  (IAGP)
abnormal palatal shelf fusion at midline  (IAGP)
abnormal palate development  (IAGP)
abnormal palate morphology  (IAGP)
abnormal palatine bone horizontal plate morphology  (IAGP)
abnormal palatine bone morphology  (IAGP)
abnormal pancreas development  (IAGP)
abnormal pelvic girdle bone morphology  (IAGP)
abnormal perineum morphology  (IAGP)
abnormal pituitary gland development  (IAGP)
abnormal placenta development  (IAGP)
abnormal placenta morphology  (IAGP)
abnormal placenta vasculature  (IAGP)
abnormal presphenoid bone morphology  (IAGP)
abnormal prostate gland branching morphogenesis  (IAGP)
abnormal pulmonary acinus morphology  (IAGP)
abnormal pulmonary circulation  (IAGP)
abnormal Rathke's pouch apoptosis  (IAGP)
abnormal Rathke's pouch development  (IAGP)
abnormal rectum morphology  (IAGP)
abnormal reproductive system physiology  (IAGP)
abnormal respiration  (IAGP)
abnormal right lung morphology  (IAGP)
abnormal sagittal suture morphology  (IAGP)
abnormal salivary gland morphology  (IAGP)
abnormal scapula morphology  (IAGP)
abnormal secondary palate development  (IAGP)
abnormal semicircular canal morphology  (IAGP)
abnormal seminal vesicle development  (IAGP)
abnormal seminal vesicle morphology  (IAGP)
abnormal seminal vesicle muscle layer morphology  (IAGP)
abnormal skeleton development  (IAGP)
abnormal skeleton physiology  (IAGP)
abnormal skin adnexa morphology  (IAGP)
abnormal skin appearance  (IAGP)
abnormal skin morphology  (IAGP)
abnormal small intestine crypts of Lieberkuhn morphology  (IAGP)
abnormal small intestine morphology  (IAGP)
abnormal sphenoid bone morphology  (IAGP)
abnormal sphenooccipital synchondrosis  (IAGP)
abnormal spongiotrophoblast layer morphology  (IAGP)
abnormal sternebra morphology  (IAGP)
abnormal sternum manubrium morphology  (IAGP)
abnormal sternum morphology  (IAGP)
abnormal sternum ossification  (IAGP)
abnormal stomach glandular region morphology  (IAGP)
abnormal stomach morphology  (IAGP)
abnormal submandibular duct morphology  (IAGP)
abnormal synaptic vesicle clustering  (IAGP)
abnormal synaptic vesicle number  (IAGP)
abnormal synchondrosis  (IAGP)
abnormal thoracic vertebrae morphology  (IAGP)
abnormal thymus development  (IAGP)
abnormal thymus morphology  (IAGP)
abnormal tongue morphology  (IAGP)
abnormal trabecula carnea morphology  (IAGP)
abnormal trabecular bone morphology  (IAGP)
abnormal tracheal cartilage morphology  (IAGP)
abnormal trophoblast layer morphology  (IAGP)
abnormal truncus arteriosus septation  (IAGP)
abnormal umbilical cord morphology  (IAGP)
abnormal ureteric bud elongation  (IAGP)
abnormal ureteric bud invasion  (IAGP)
abnormal ureteric bud morphology  (IAGP)
abnormal urethra morphology  (IAGP)
abnormal urethra urothelium morphology  (IAGP)
abnormal vascular development  (IAGP)
abnormal vasodilation  (IAGP)
abnormal vertebrae development  (IAGP)
abnormal vertebrae morphology  (IAGP)
abnormal vestibulocochlear ganglion morphology  (IAGP)
abnormal vibrissa number  (IAGP)
abnormal xiphoid process morphology  (IAGP)
abnormal zigzag hair morphology  (IAGP)
abnormal zygomatic arch morphology  (IAGP)
abnormal zygomatic bone morphology  (IAGP)
absent acromion  (IAGP)
absent adenohypophysis  (IAGP)
absent apical ectodermal ridge  (IAGP)
absent blastocoele  (IAGP)
absent exorbital lacrimal gland  (IAGP)
absent eyelids  (IAGP)
absent forelimb  (IAGP)
absent hair follicles  (IAGP)
absent hindlimb  (IAGP)
absent hypodermis muscle layer  (IAGP)
absent kidney  (IAGP)
absent lacrimal gland bud  (IAGP)
absent lacrimal glands  (IAGP)
absent limb buds  (IAGP)
absent limbs  (IAGP)
absent lungs  (IAGP)
absent mammary gland  (IAGP)
absent mast cells  (IAGP)
absent metanephric mesenchyme  (IAGP)
absent palatal rugae  (IAGP)
absent placental labyrinth  (IAGP)
absent presphenoid bone  (IAGP)
absent primitive endoderm  (IAGP)
absent pubis  (IAGP)
absent pulmonary artery  (IAGP)
absent pulmonary vein  (IAGP)
absent Rathke's pouch  (IAGP)
absent rectum  (IAGP)
absent sebaceous gland  (IAGP)
absent submandibular gland  (IAGP)
absent teeth  (IAGP)
absent telencephalon  (IAGP)
absent thyroid gland  (IAGP)
absent vertebral spinous process  (IAGP)
acanthosis  (IAGP)
adipose tissue inflammation  (IAGP)
aerophagia  (IAGP)
alopecia  (IAGP)
arrest of tooth development  (IAGP)
atelectasis  (IAGP)
bronchiolectasis  (IAGP)
caudal vertebral fusion  (IAGP)
cecal atresia  (IAGP)
cervical vertebral fusion  (IAGP)
cleft palate  (IAGP)
cleft secondary palate  (IAGP)
conotruncal ridge hypoplasia  (IAGP)
curly tail  (IAGP)
decreased birth body size  (IAGP)
decreased birth weight  (IAGP)
decreased body length  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased bone mineral density  (IAGP)
decreased bone volume  (IAGP)
decreased brain size  (IAGP)
decreased cell proliferation  (IAGP)
decreased cranium height  (IAGP)
decreased cranium length  (IAGP)
decreased embryo size  (IAGP)
decreased fetal size  (IAGP)
decreased hair follicle number  (IAGP)
decreased inner canthal distance  (IAGP)
decreased kidney cell proliferation  (IAGP)
decreased molar number  (IAGP)
decreased nephron number  (IAGP)
decreased osteoblast cell number  (IAGP)
decreased osteoclast cell number  (IAGP)
decreased palatal length  (IAGP)
decreased prostate gland duct number  (IAGP)
decreased renal glomerulus number  (IAGP)
decreased sebaceous gland number  (IAGP)
decreased skin pigmentation  (IAGP)
decreased submandibular gland size  (IAGP)
decreased width of hypertrophic chondrocyte zone  (IAGP)
delayed bone ossification  (IAGP)
delayed cranial suture closure  (IAGP)
delayed intramembranous bone ossification  (IAGP)
dermatitis  (IAGP)
dilated distal convoluted tubule  (IAGP)
dilated heart atrium  (IAGP)
dilated proximal convoluted tubule  (IAGP)
disproportionate dwarf  (IAGP)
domed cranium  (IAGP)
double outlet right ventricle  (IAGP)
dry skin  (IAGP)
ectopic ureteric bud  (IAGP)
embryonic growth retardation  (IAGP)
embryonic lethality between implantation and somite formation, complete penetrance  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
enhanced osteoblast differentiation  (IAGP)
enlarged allantois  (IAGP)
enlarged fourth ventricle  (IAGP)
enlarged lateral ventricles  (IAGP)
epidermal cyst  (IAGP)
epidermal hyperplasia  (IAGP)
epidermis stratum granulosum hyperplasia  (IAGP)
epidermis stratum spinosum hyperplasia  (IAGP)
exophthalmos  (IAGP)
eyelids open at birth  (IAGP)
facial cleft  (IAGP)
failure of chorioallantoic fusion  (IAGP)
female infertility  (IAGP)
frontonasal prominence hypoplasia  (IAGP)
fused joints  (IAGP)
fused tracheal cartilage rings  (IAGP)
genital tubercle hypoplasia  (IAGP)
heart hypoplasia  (IAGP)
heart left atrium hypoplasia  (IAGP)
heart right ventricle hypoplasia  (IAGP)
hydrocephaly  (IAGP)
hydronephrosis  (IAGP)
hypoglycemia  (IAGP)
hypospadia  (IAGP)
impaired branching involved in bronchus morphogenesis  (IAGP)
impaired branching involved in trachea morphogenesis  (IAGP)
impaired branching involved in ureteric bud morphogenesis  (IAGP)
impaired lung alveolus development  (IAGP)
impaired lung lobe morphogenesis  (IAGP)
impaired skin barrier function  (IAGP)
increased brain size  (IAGP)
increased cell death  (IAGP)
increased cranium height  (IAGP)
increased cranium width  (IAGP)
increased gamma-delta T cell number  (IAGP)
increased IgE level  (IAGP)
increased IgG1 level  (IAGP)
increased IgG2a level  (IAGP)
increased incidence of tumors by chemical induction  (IAGP)
increased keratinocyte proliferation  (IAGP)
increased kidney apoptosis  (IAGP)
increased mast cell number  (IAGP)
increased metanephric mesenchyme apoptosis  (IAGP)
increased osteoblast cell number  (IAGP)
increased osteoblast proliferation  (IAGP)
increased prostate gland weight  (IAGP)
increased skin papilloma incidence  (IAGP)
increased trophoblast giant cell number  (IAGP)
inner cell mass degeneration  (IAGP)
inner ear cyst  (IAGP)
lethality throughout fetal growth and development  (IAGP)
long incisors  (IAGP)
malocclusion  (IAGP)
meteorism  (IAGP)
microphthalmia  (IAGP)
midface hypoplasia  (IAGP)
muscular ventricular septal defect  (IAGP)
neonatal lethality  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
no abnormal phenotype detected  (IAGP)
ocular hypertelorism  (IAGP)
overriding aortic valve  (IAGP)
palatal shelf fusion with tongue or mandible  (IAGP)
palatal shelves fail to meet at midline  (IAGP)
parakeratosis  (IAGP)
parietal bossing  (IAGP)
perimembraneous ventricular septal defect  (IAGP)
perinatal lethality, complete penetrance  (IAGP)
perineal hypospadia  (IAGP)
polydipsia  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
premature coronal suture closure  (IAGP)
premature cranial suture closure  (IAGP)
premature death  (IAGP)
premature facial suture closure  (IAGP)
premature frontonasal suture closure  (IAGP)
premature intramembranous bone ossification  (IAGP)
premature lambdoid suture closure  (IAGP)
premature maxillary-premaxillary suture closure  (IAGP)
premature palatomaxillary suture closure  (IAGP)
premature presphenoid synchondrosis closure  (IAGP)
premature sphenooccipital synchondrosis closure  (IAGP)
premature squamoparietal suture closure  (IAGP)
premature zygomaticomaxillary suture closure  (IAGP)
primary sex reversal  (IAGP)
progressive hair loss  (IAGP)
pulmonary alveolar proteinosis  (IAGP)
pulmonary hypoplasia  (IAGP)
reduced male fertility  (IAGP)
respiratory distress  (IAGP)
respiratory failure  (IAGP)
sebaceous gland atrophy  (IAGP)
shallow orbits  (IAGP)
short basicranium  (IAGP)
short face  (IAGP)
short femur  (IAGP)
short frontal bone  (IAGP)
short humerus  (IAGP)
short mandible  (IAGP)
short maxilla  (IAGP)
short nasal bone  (IAGP)
short premaxilla  (IAGP)
short presphenoid bone  (IAGP)
short radius  (IAGP)
short rostral-caudal axis  (IAGP)
short snout  (IAGP)
short tibia  (IAGP)
short zygomatic arch  (IAGP)
short zygomatic bone  (IAGP)
shortened head  (IAGP)
skin fibrosis  (IAGP)
skin inflammation  (IAGP)
slow postnatal weight gain  (IAGP)
small cranium  (IAGP)
small face  (IAGP)
small frontal bone  (IAGP)
small hair follicles  (IAGP)
small kidney  (IAGP)
small lung  (IAGP)
small mandible  (IAGP)
small neurocranium  (IAGP)
small otic capsule  (IAGP)
small otic vesicle  (IAGP)
small pancreas  (IAGP)
small parietal bone  (IAGP)
small scapula  (IAGP)
small stomach  (IAGP)
small ureteric bud  (IAGP)
split sternal manubrium  (IAGP)
split sternum  (IAGP)
split xiphoid process  (IAGP)
submandibular gland hypoplasia  (IAGP)
syndactyly  (IAGP)
synostosis  (IAGP)
telencephalon hypoplasia  (IAGP)
thick epidermis  (IAGP)
thick nasal septum  (IAGP)
thin dermal layer  (IAGP)
thin epidermis  (IAGP)
thin frontal bone  (IAGP)
thin left ventricle myocardium compact layer  (IAGP)
thin parietal bone  (IAGP)
thin skin  (IAGP)
thin ventricular wall  (IAGP)
tongue ankylosis  (IAGP)
translucent skin  (IAGP)
tremors  (IAGP)
vertebral fusion  (IAGP)
wide cranial sutures  (IAGP)
wide intermaxillary suture  (IAGP)
wide metopic suture  (IAGP)
wide sagittal suture  (IAGP)

References - curated
# Reference Title Reference Citation
1. Early-onset low-grade papillary carcinoma of the bladder associated with Apert syndrome and a germline FGFR2 mutation (Pro253Arg). Andreou A, etal., Am J Med Genet A. 2006 Oct 15;140(20):2245-7.
2. Beare-Stevenson syndrome: two Dutch patients with cerebral abnormalities. Barge-Schaapveld DQ, etal., Pediatr Neurol. 2011 Apr;44(4):303-7.
3. Neuron and microglia/macrophage-derived FGF10 activate neuronal FGFR2/PI3K/Akt signaling and inhibit microglia/macrophages TLR4/NF-κB-dependent neuroinflammation to improve functional recovery after spinal cord injury. Chen J, etal., Cell Death Dis. 2017 Oct 5;8(10):e3090. doi: 10.1038/cddis.2017.490.
4. A Ser252Trp [corrected] substitution in mouse fibroblast growth factor receptor 2 (Fgfr2) results in craniosynostosis. Chen L, etal., Bone. 2003 Aug;33(2):169-78.
5. FGF-21 ameliorates essential hypertension of SHR via baroreflex afferent function. Chen P, etal., Brain Res Bull. 2020 Jan;154:9-20. doi: 10.1016/j.brainresbull.2019.10.003. Epub 2019 Oct 15.
6. Risk of aggressive breast cancer in women of Han nationality carrying TGFB1 rs1982073 C allele and FGFR2 rs1219648 G allele in North China. Chen XH, etal., Breast Cancer Res Treat. 2011 Jan;125(2):575-82. doi: 10.1007/s10549-010-1032-7. Epub 2010 Jul 17.
7. Overexpression of the fibroblast growth factor receptor 2-IIIc in Kaposi's sarcoma. Cottoni F, etal., J Dermatol Sci. 2009 Jan;53(1):65-8. doi: 10.1016/j.jdermsci.2008.07.012. Epub 2008 Sep 19.
8. Decreased expression of keratinocyte growth factor receptor in a subset of human transitional cell bladder carcinomas. Diez de Medina SG, etal., Oncogene. 1997 Jan 23;14(3):323-30.
9. A new synthetic FGF receptor antagonist inhibits arteriosclerosis in a mouse vein graft model and atherosclerosis in apolipoprotein E-deficient mice. Dol-Gleizes F, etal., PLoS One. 2013 Nov 4;8(11):e80027. doi: 10.1371/journal.pone.0080027. eCollection 2013.
10. Drug-sensitive FGFR2 mutations in endometrial carcinoma. Dutt A, etal., Proc Natl Acad Sci U S A. 2008 Jun 24;105(25):8713-7. Epub 2008 Jun 13.
11. Genome-wide association study identifies novel breast cancer susceptibility loci. Easton DF, etal., Nature. 2007 Jun 28;447(7148):1087-93.
12. Is the fibroblast growth factor signaling pathway a victim of receptor tyrosine kinase inhibition in pulmonary parenchymal and vascular remodeling? El Agha E, etal., Am J Physiol Lung Cell Mol Physiol. 2018 Aug 1;315(2):L248-L252. doi: 10.1152/ajplung.00140.2018. Epub 2018 May 3.
13. Fibroblast growth factor receptor 2 IIIb invalidation--a potential cause of familial duodenal atresia. Fairbanks TJ, etal., J Pediatr Surg. 2004 Jun;39(6):872-4.
14. Second case of Beare-Stevenson syndrome with an FGFR2 Ser372Cys mutation. Fonseca R, etal., Am J Med Genet A. 2008 Mar 1;146A(5):658-60.
15. Ethanol inhibits fibroblast growth factor-induced proliferation of aortic smooth muscle cells. Ghiselli G, etal., Arterioscler Thromb Vasc Biol. 2003 Oct 1;23(10):1808-13. doi: 10.1161/01.ATV.0000090140.20291.CE. Epub 2003 Aug 7.
16. Two animal models of retinal degeneration are rescued by recombinant adeno-associated virus-mediated production of FGF-5 and FGF-18. Green ES, etal., Mol Ther. 2001 Apr;3(4):507-15.
17. Immunohistochemical detection of K-sam protein in stomach cancer. Hattori Y, etal., Clin Cancer Res. 1996 Aug;2(8):1373-81.
18. FGFR-associated craniosynostosis syndromes and gastrointestinal defects. Hibberd CE, etal., Am J Med Genet A. 2016 Dec;170(12):3215-3221. doi: 10.1002/ajmg.a.37862. Epub 2016 Aug 2.
19. A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer. Hunter DJ, etal., Nat Genet. 2007 Jul;39(7):870-4. Epub 2007 May 27.
20. Jackson-Weiss and Crouzon syndromes are allelic with mutations in fibroblast growth factor receptor 2. Jabs EW, etal., Nat Genet. 1994 Nov;8(3):275-9.
21. Mutations in fibroblast growth factor receptor 2 and fibroblast growth factor receptor 3 genes associated with human gastric and colorectal cancers. Jang JH, etal., Cancer Res. 2001 May 1;61(9):3541-3.
22. The fibroblast growth factor receptor 2 p.Ala172Phe mutation in Pfeiffer syndrome--history repeating itself. Jay S, etal., Am J Med Genet A. 2013 May;161A(5):1158-63. doi: 10.1002/ajmg.a.35842. Epub 2013 Mar 26.
23. Reduced Fgf10/Fgfr2 and androgen receptor (AR) in anorectal malformations male rats induced by di-n-butyl phthalate (DBP): A study on the local and systemic toxicology of DBP. Jiang JT, etal., Toxicology. 2015 Dec 2;338:77-85. doi: 10.1016/j.tox.2015.10.006. Epub 2015 Oct 26.
24. Cooperation between ectopic FGFR1 and depression of FGFR2 in induction of prostatic intraepithelial neoplasia in the mouse prostate. Jin C, etal., Cancer Res. 2003 Dec 15;63(24):8784-90.
25. Upregulation of ANGPTL4 messenger RNA and protein in severely calcified carotid plaques. Katano H and Yamada K, J Stroke Cerebrovasc Dis. 2014 May-Jun;23(5):933-47. doi: 10.1016/j.jstrokecerebrovasdis.2013.07.046. Epub 2013 Sep 26.
26. Feeding, Communication, Hydrocephalus, and Intracranial Hypertension in Patients With Severe FGFR2-Associated Pfeiffer Syndrome. Kilcoyne S, etal., J Craniofac Surg. 2021 Jan-Feb 01;32(1):134-140. doi: 10.1097/SCS.0000000000007153.
27. Effect of Fibroblast Growth Factor-2 and its Receptor Gene Polymorphisms on the Survival of Patients With Hepatitis B Virus-associated Hepatocellular Carcinoma. Kim SS, etal., Anticancer Res. 2019 Apr;39(4):2217-2226. doi: 10.21873/anticanres.13337.
28. Keratinocyte growth factor expression in hormone insensitive prostate cancer. Leung HY, etal., Oncogene. 1997 Aug 28;15(9):1115-20.
29. Gene profiling in Pap-cell smears of high-risk human papillomavirus-positive squamous cervical carcinoma. Manavi M, etal., Gynecol Oncol. 2007 May;105(2):418-26. Epub 2007 Feb 15.
30. Congenital heart defects in Fgfr2-IIIb and Fgf10 mutant mice. Marguerie A, etal., Cardiovasc Res. 2006 Jul 1;71(1):50-60. doi: 10.1016/j.cardiores.2006.03.021. Epub 2006 Apr 4.
31. Endothelium-targeted overexpression of constitutively active FGF receptor induces cardioprotection in mice myocardial infarction. Matsunaga S, etal., J Mol Cell Cardiol. 2009 May;46(5):663-73. doi: 10.1016/j.yjmcc.2009.01.015.
32. Novel phenotype of craniosynostosis and ocular anterior chamber dysgenesis with a fibroblast growth factor receptor 2 mutation. McCann E, etal., Am J Med Genet A. 2005 Oct 15;138A(3):278-81.
33. Novel breast cancer risk alleles and endometrial cancer risk. McGrath M, etal., Int J Cancer. 2008 Sep 10.
34. Fibroblast growth factor receptor-2 mutation analysis in human prostate cancer. Mehta P, etal., BJU Int. 2000 Oct;86(6):681-5.
35. Unilateral segmental acneiform naevus: a model disorder towards understanding fibroblast growth factor receptor 2 function in acne? Melnik BC, etal., Br J Dermatol. 2008 Jun;158(6):1397-9. doi: 10.1111/j.1365-2133.2008.08559.x. Epub 2008 Apr 10.
36. Bent bone dysplasia-FGFR2 type, a distinct skeletal disorder, has deficient canonical FGF signaling. Merrill AE, etal., Am J Hum Genet. 2012 Mar 9;90(3):550-7. doi: 10.1016/j.ajhg.2012.02.005. Epub 2012 Mar 1.
37. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
38. MGDs mouse GO annotations MGD data from the GO Consortium
40. Comparative mapping of novel simple sequence repeat markers in a hypertension-related region on rat chromosome 1. Nabika T, etal., Mamm Genome 1997 Mar;8(3):215-7.
41. Single nucleotide polymorphisms of the fibroblast growth factor receptor 2 gene in patients with chronic venous insufficiency with leg ulcer. Nagy N, etal., J Invest Dermatol. 2005 May;124(5):1085-8. doi: 10.1111/j.0022-202X.2005.23689.x.
42. Down-regulation of (IIIb) and (IIIc) isoforms of fibroblast growth factor receptor 2 (FGFR2) is associated with malignant progression in human prostate. Naimi B, etal., Prostate. 2002 Aug 1;52(3):245-52.
43. Conditional mutation of fibroblast growth factor receptors 1 and 2 results in an omphalocele in mice associated with disruptions in ventral body wall muscle formation. Nichol PF, etal., J Pediatr Surg. 2011 Jan;46(1):90-6. doi: 10.1016/j.jpedsurg.2010.09.066.
44. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
45. Analysis of phenotypic features and FGFR2 mutations in Apert syndrome. Park WJ, etal., Am J Hum Genet. 1995 Aug;57(2):321-8.
46. Description of a new mutation and characterization of FGFR1, FGFR2, and FGFR3 mutations among Brazilian patients with syndromic craniosynostoses. Passos-Bueno MR, etal., Am J Med Genet. 1998 Jul 7;78(3):237-41.
47. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
48. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
49. Link between reduced nephron number and hypertension: studies in a mutant mouse model. Poladia DP, etal., Pediatr Res. 2006 Apr;59(4 Pt 1):489-93. doi: 10.1203/01.pdr.0000202764.02295.45.
50. Frequent activating FGFR2 mutations in endometrial carcinomas parallel germline mutations associated with craniosynostosis and skeletal dysplasia syndromes. Pollock PM, etal., Oncogene. 2007 Nov 1;26(50):7158-62. Epub 2007 May 21.
51. Spectrum of craniosynostosis phenotypes associated with novel mutations at the fibroblast growth factor receptor 2 locus. Pulleyn LJ, etal., Eur J Hum Genet. 1996;4(5):283-91.
52. Facial suture synostosis of newborn Fgfr1(P250R/+) and Fgfr2(S252W/+) mouse models of Pfeiffer and Apert syndromes. Purushothaman R, etal., Birth Defects Res A Clin Mol Teratol. 2011 Jul;91(7):603-9. doi: 10.1002/bdra.20811. Epub 2011 Apr 28.
53. Influenza Virus Infects Epithelial Stem/Progenitor Cells of the Distal Lung: Impact on Fgfr2b-Driven Epithelial Repair. Quantius J, etal., PLoS Pathog. 2016 Jun 20;12(6):e1005544. doi: 10.1371/journal.ppat.1005544. eCollection 2016 Jun.
54. Evidence for digenic inheritance in some cases of Antley-Bixler syndrome? Reardon W, etal., J Med Genet. 2000 Jan;37(1):26-32.
55. Mutations in the fibroblast growth factor receptor 2 gene cause Crouzon syndrome. Reardon W, etal., Nat Genet. 1994 Sep;8(1):98-103. doi: 10.1038/ng0994-98.
56. Mouse MP Annotation Import Pipeline RGD automated import pipeline
57. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
58. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
59. Tumour suppressive properties of fibroblast growth factor receptor 2-IIIb in human bladder cancer. Ricol D, etal., Oncogene. 1999 Dec 2;18(51):7234-43.
60. Ovarian dysgerminoma and Apert syndrome. Rouzier C, etal., Pediatr Blood Cancer. 2008 Mar;50(3):696-8.
61. Sequence analysis of fibroblast growth factor receptor 2 ( FGFR2 ) in Japanese patients with craniosynostosis. Sakai N, etal., J Craniofac Surg. 2001 Nov;12(6):580-5.
62. Mutations in FGFR1 and FGFR2 cause familial and sporadic Pfeiffer syndrome. Schell U, etal., Hum Mol Genet. 1995 Mar;4(3):323-8. doi: 10.1093/hmg/4.3.323.
63. Medical treatment of craniosynostosis: recombinant Noggin inhibits coronal suture closure in the rat craniosynostosis model. Shen K, etal., Orthod Craniofac Res. 2009 Aug;12(3):254-62. doi: 10.1111/j.1601-6343.2009.01460.x.
64. RNA interference and inhibition of MEK-ERK signaling prevent abnormal skeletal phenotypes in a mouse model of craniosynostosis. Shukla V, etal., Nat Genet. 2007 Sep;39(9):1145-50. Epub 2007 Aug 12.
65. Novel FGFR2 deletion in a patient with Beare-Stevenson-like syndrome. Slavotinek A, etal., Am J Med Genet A. 2009 Aug;149A(8):1814-7.
66. Aberrant fibroblast growth factor receptor 2 signalling in esophageal atresia with tracheoesophageal fistula. Spilde TL, etal., J Pediatr Surg. 2004 Apr;39(4):537-9.
67. Induction of FGF receptor 2-IIIb expression and response to its ligands in epithelial ovarian cancer. Steele IA, etal., Oncogene. 2001 Sep 13;20(41):5878-87.
68. Luteolin limits infarct size and improves cardiac function after myocardium ischemia/reperfusion injury in diabetic rats. Sun D, etal., PLoS One. 2012;7(3):e33491. doi: 10.1371/journal.pone.0033491. Epub 2012 Mar 14.
69. Aberrant expression of keratinocyte growth factor receptor in ovarian surface epithelial cells of endometrioma. Taniguchi F, etal., Fertil Steril. 2008 Feb;89(2):478-80. Epub 2007 May 4.
70. Reduced expression of basic fibroblast growth factor and its receptor mRNAs and proteins in portal hypertensive esophageal mucosa: a mechanism responsible for muscularis mucosae thinning and variceal rupture. Tanoue K, etal., Surgery. 1996 Apr;119(4):424-30. doi: 10.1016/s0039-6060(96)80143-7.
71. Differential roles of fibroblast growth factor receptors (FGFR) 1, 2 and 3 in the regulation of S115 breast cancer cell growth. Tarkkonen KM, etal., PLoS One. 2012;7(11):e49970. doi: 10.1371/journal.pone.0049970. Epub 2012 Nov 21.
72. Mutation analysis of Crouzon syndrome and identification of one novel mutation in Taiwanese patients. Tsai FJ, etal., Pediatr Int. 2001 Jun;43(3):263-6.
73. Cyclooxygenase-2 and hypoxia-regulated proteins are modulated by basic fibroblast growth factor in acute renal failure. Villanueva S, etal., Biol Res. 2012;45(1):51-60. doi: 10.4067/S0716-97602012000100007.
74. Intrarenal urothelium proliferation: an unexpected early event following ischemic injury. Vinsonneau C, etal., Am J Physiol Renal Physiol. 2010 Sep;299(3):F479-86. doi: 10.1152/ajprenal.00585.2009. Epub 2010 Jun 30.
75. Genotype-phenotype analysis in Apert syndrome suggests opposite effects of the two recurrent mutations on syndactyly and outcome of craniofacial surgery. von Gernet S, etal., Clin Genet. 2000 Feb;57(2):137-9.
76. Mutations that cause osteoglophonic dysplasia define novel roles for FGFR1 in bone elongation. White KE, etal., Am J Hum Genet. 2005 Feb;76(2):361-7. Epub 2004 Dec 28.
77. Preclinical Combination Studies of an FGFR2 Targeted Thorium-227 Conjugate and the ATR Inhibitor BAY 1895344. Wickstroem K, etal., Int J Radiat Oncol Biol Phys. 2019 Oct 1;105(2):410-422. doi: 10.1016/j.ijrobp.2019.06.2508. Epub 2019 Jun 27.
78. KGF-2 Protects against Lung Ischemia-Reperfusion Injury by Inhibiting Inflammation-Induced Damage to Endothelial Barrier Function. Xia F, etal., Evid Based Complement Alternat Med. 2022 May 11;2022:3055039. doi: 10.1155/2022/3055039. eCollection 2022.
79. Ablation of FGFR2 in Fibroblasts Ameliorates Kidney Fibrosis after Ischemia/Reperfusion Injury in Mice. Xu Z and Dai C, Kidney Dis (Basel). 2017 Dec;3(4):160-170. doi: 10.1159/000484604. Epub 2017 Nov 16.
80. FGF/FGFR2 Protects against Tubular Cell Death and Acute Kidney Injury Involving Erk1/2 Signaling Activation. Xu Z, etal., Kidney Dis (Basel). 2020 May;6(3):181-194. doi: 10.1159/000505661. Epub 2020 Feb 7.
81. Genotypic and phenotypic analyses of Korean patients with syndromic craniosynostosis. Yu JE, etal., Clin Genet. 2009 Sep;76(3):287-91. Epub 2009 Jul 17.
82. TM2D3 rs675436 or FGFR2 rs755793 polymorphisms and susceptibility to Epstein-Barr virus-associated tumors in Chinese Han population. Zhang Q, etal., J Med Virol. 2018 Jun;90(6):1128-1133. doi: 10.1002/jmv.25057. Epub 2018 Feb 27.
83. Common variation in the fibroblast growth factor receptor 2 gene is not associated with endometriosis risk. Zhao ZZ, etal., Hum Reprod. 2008 Jul;23(7):1661-8. Epub 2008 Feb 18.
84. Molecular and toxicologic research in newborn hypospadiac male rats following in utero exposure to di-n-butyl phthalate (DBP). Zhu YJ, etal., Toxicology. 2009 Jun 16;260(1-3):120-5. Epub 2009 Apr 5.
Additional References at PubMed
PMID:1309608   PMID:1315677   PMID:1373495   PMID:1408137   PMID:1667382   PMID:1711190   PMID:1846048   PMID:2161540   PMID:2165484   PMID:2468999   PMID:3181757   PMID:7542761  
PMID:7593222   PMID:7604876   PMID:7640656   PMID:7655084   PMID:7670492   PMID:7789972   PMID:7896824   PMID:7959747   PMID:7973639   PMID:8026341   PMID:8045260   PMID:8382556  
PMID:8393815   PMID:8585128   PMID:8601314   PMID:8619928   PMID:8854873   PMID:8883961   PMID:8901049   PMID:8903721   PMID:8954725   PMID:8959336   PMID:8986768   PMID:9010207  
PMID:9013630   PMID:9056643   PMID:9136983   PMID:9202386   PMID:9286594   PMID:9