Fgfr2 (fibroblast growth factor receptor 2) - Rat Genome Database

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Gene: Fgfr2 (fibroblast growth factor receptor 2) Mus musculus
Symbol: Fgfr2
Name: fibroblast growth factor receptor 2
RGD ID: 10581
Description: Enables fibroblast growth factor binding activity. Involved in several processes, including fibroblast growth factor receptor signaling pathway; forebrain generation of neurons; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including lung development; morphogenesis of an epithelium; and positive regulation of cell population proliferation. Located in excitatory synapse and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; limb; and sensory organ. Used to study Beare-Stevenson cutis gyrata syndrome; atopic dermatitis; intestinal atresia; and synostosis (multiple). Human ortholog(s) of this gene implicated in several diseases, including Beare-Stevenson cutis gyrata syndrome; Jackson-Weiss syndrome; gastrointestinal system cancer (multiple); reproductive organ cancer (multiple); and synostosis (multiple). Orthologous to human FGFR2 (fibroblast growth factor receptor 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AU043015; AW556123; Bek; Fgfr; Fgfr-; Fgfr-2; Fgfr-7; Fgfr2b; Fgfr7; keratinocyte growth factor receptor; KGFR; KGFRTr; MGC102519; svs
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm397129,764,181 - 129,868,538 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7129,764,181 - 132,725,079 (-)EnsemblGRCm39 Ensembl
GRCm387130,162,451 - 130,266,808 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7130,162,451 - 133,123,350 (-)EnsemblGRCm38mm10GRCm38
MGSCv377137,305,965 - 137,410,322 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367129,954,867 - 130,057,411 (-)NCBIMGSCv36mm8
Celera7129,989,855 - 130,093,942 (-)NCBICelera
Cytogenetic Map7F3NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
Acneiform Eruptions  (ISO)
acrocephalosyndactylia  (IAGP,IMP,ISO)
adenoid cystic carcinoma  (ISO)
ankylosis  (ISO)
Anorectal Malformations  (ISO)
Antley-Bixler syndrome  (ISO)
Antley-Bixler syndrome with disordered steroidogenesis  (ISO)
Antley-Bixler syndrome without disordered steroidogenesis  (ISO)
atherosclerosis  (IDA)
Beare-Stevenson cutis gyrata syndrome  (IAGP,ISO)
Bent Bone Dysplasia Syndrome 1  (ISO)
breast cancer  (IMP,ISO)
Breast Neoplasms  (ISO)
Chemical Burns  (ISO)
cholangiocarcinoma  (ISO)
cleft lip  (ISO)
cleft palate  (ISO)
colorectal adenocarcinoma  (ISO)
colorectal cancer  (ISO)
Congenital Aural Atresia  (ISO)
Congenital Limb Deformities  (ISO)
Craniofacial Abnormalities  (IMP,ISO)
craniosynostosis  (IMP,ISO)
Craniosynostosis Syndrome, Autosomal Recessive  (ISO)
Crouzon syndrome  (IAGP,ISO)
developmental coordination disorder  (ISO)
disorder of sexual development  (ISO)
duodenal atresia  (IMP)
dysgerminoma  (ISO)
endometrial carcinoma  (ISO)
Endometrial Neoplasms  (ISO)
Endometrioid Carcinomas  (ISO)
endometriosis  (ISO)
Epstein-Barr Virus Infections  (ISO)
esophageal carcinoma  (ISO)
essential hypertension  (ISO)
female breast carcinoma  (ISO)
gastric adenocarcinoma  (ISO)
genetic disease  (ISO)
head and neck cancer  (ISO)
hepatocellular carcinoma  (ISO)
Hypertelorism  (ISO)
hypospadias  (ISO)
idiopathic pulmonary fibrosis  (ISO)
intellectual disability  (ISO)
intestinal atresia  (IAGP)
Jackson-Weiss syndrome  (ISO)
Kaposi's sarcoma  (ISO)
Kidney Reperfusion Injury  (IEP,IMP,ISO)
LADD syndrome  (ISO)
LADD Syndrome 1  (ISO)
Left Ventricular Hypertrophy  (IMP)
Leg Ulcer  (ISO)
liver cirrhosis  (ISO)
lung adenocarcinoma  (ISO)
Lung Neoplasms  (ISO)
Lung Reperfusion Injury  (ISO)
lung squamous cell carcinoma  (ISO)
Lymphatic Metastasis  (ISO)
Multiple Abnormalities  (ISO)
myocardial infarction  (IMP)
Nasopharyngeal Neoplasms  (ISO)
Ovarian Neoplasms  (ISO)
Pfeiffer syndrome  (IAGP,ISO)
Plagiocephaly, Nonsynostotic  (ISO)
Plaque, Atherosclerotic  (ISO)
portal hypertension  (ISO)
primary pulmonary hypertension  (ISO)
prostate cancer  (ISO)
prostate carcinoma in situ  (IMP)
PTEN hamartoma tumor syndrome  (ISO)
retinitis pigmentosa  (ISO)
Saethre-Chotzen syndrome  (ISO)
Scaphocephaly, Maxillary Retrusion, and Impaired Intellectual Development  (ISO)
sensorineural hearing loss  (ISO)
Skin Abnormalities  (ISO)
skin disease  (ISO)
spina bifida  (ISO)
Spinal Cord Compression  (ISO)
split hand-foot malformation  (ISO)
squamous cell carcinoma  (ISO)
stomach cancer  (ISO)
stomach carcinoma  (ISO)
Stomach Neoplasms  (ISO)
Tooth Abnormalities  (ISO)
Tracheoesophageal Fistula  (ISO)
transient cerebral ischemia  (ISO)
transitional cell carcinoma  (ISO)
umbilical hernia  (IMP)
urinary bladder cancer  (ISO)
uterine cancer  (ISO)
uterine carcinosarcoma  (ISO)
Uterine Cervical Neoplasms  (ISO)
ventricular septal defect  (IMP)
viral pneumonia  (IEP,IMP)
Volvulus Of Midgut  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
1-(5-isoquinolinesulfonyl)-2-methylpiperazine  (ISO)
1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5-triiodo-L-thyronine  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
3-methylcholanthrene  (EXP)
3-Nitrobenzanthrone  (ISO)
3-phenylprop-2-enal  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (EXP)
5-(2-methylpiperazine-1-sulfonyl)isoquinoline  (ISO)
5-aza-2'-deoxycytidine  (EXP)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
acetone  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzene  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bifenthrin  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
buspirone  (ISO)
Butylbenzyl phthalate  (ISO)
Butylparaben  (ISO)
cadmium atom  (EXP,ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
carbon nanotube  (EXP,ISO)
carbonyl sulfide  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
clofibrate  (EXP)
colforsin daropate hydrochloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
crocidolite asbestos  (ISO)
cumene hydroperoxide  (EXP)
Cuprizon  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
cyhalothrin  (ISO)
decabromodiphenyl ether  (ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
diazepam  (ISO)
dibutyl phthalate  (ISO)
diethyl malate  (EXP)
dioxygen  (EXP)
dipentyl phthalate  (ISO)
disodium selenite  (EXP)
doxorubicin  (ISO)
endosulfan  (ISO)
enzacamene  (ISO)
ethanol  (EXP,ISO)
flavonoids  (ISO)
fluprostenol  (ISO)
fluvalinate  (ISO)
genistein  (ISO)
gentamycin  (ISO)
heparan sulfate  (ISO)
heparin  (EXP,ISO)
hydrogen peroxide  (EXP,ISO)
indole-3-methanol  (ISO)
lenalidomide  (ISO)
linuron  (ISO)
manganese(II) chloride  (ISO)
menadione  (ISO)
mercury dibromide  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
mifepristone  (ISO)
monosodium L-glutamate  (EXP)
N,N-diethyl-m-toluamide  (ISO)
N-(1-naphthyl)ethylenediamine  (EXP)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (EXP)
nefazodone  (ISO)
Neferine  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
nitrofen  (ISO)
nitroglycerin  (ISO)
O-methyleugenol  (ISO)
oxaliplatin  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
pentane-2,3-dione  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (ISO)
phenobarbital  (EXP)
phenytoin  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
pirinixic acid  (EXP,ISO)
ponatinib  (ISO)
potassium dichromate  (EXP)
progesterone  (EXP,ISO)
prostaglandin F2alpha  (ISO)
raloxifene  (ISO)
reactive oxygen species  (EXP)
Rebamipide  (ISO)
silicon dioxide  (ISO)
sodium dichromate  (EXP)
sucrose octasulfate  (ISO)
suramin  (ISO)
tamoxifen  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
thalidomide  (ISO)
thimerosal  (ISO)
thioacetamide  (ISO)
tipifarnib  (ISO)
topotecan  (ISO)
trichloroethene  (ISO)
trimellitic anhydride  (EXP)
triptonide  (EXP)
troglitazone  (EXP)
valproic acid  (ISO)
vanadyl sulfate  (ISO)
vanillin  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (IGI)
animal organ morphogenesis  (IMP)
apoptotic process  (IEA)
axonogenesis  (IMP)
bone development  (IMP)
bone mineralization  (IMP)
bone morphogenesis  (IMP)
branch elongation involved in salivary gland morphogenesis  (IGI,IMP)
branching involved in labyrinthine layer morphogenesis  (IMP)
branching involved in prostate gland morphogenesis  (IMP)
branching involved in salivary gland morphogenesis  (IMP)
branching morphogenesis of a nerve  (IMP)
bud elongation involved in lung branching  (IMP)
canonical Wnt signaling pathway  (IGI)
cardiac muscle cell proliferation  (IGI)
cell division  (IMP)
cell fate commitment  (IDA,IMP)
cell population proliferation  (IGI,IMP)
cell-cell signaling  (IMP)
cellular response to fibroblast growth factor stimulus  (ISO)
cellular response to hypoxia  (ISO)
cellular response to retinoic acid  (ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
coronal suture morphogenesis  (IMP)
digestive tract development  (IMP)
embryonic cranial skeleton morphogenesis  (ISO)
embryonic digestive tract morphogenesis  (IMP)
embryonic organ development  (IMP)
embryonic organ morphogenesis  (IMP)
embryonic pattern specification  (IMP)
endochondral bone growth  (ISO)
endodermal digestive tract morphogenesis  (IMP)
epidermis morphogenesis  (IMP)
epithelial cell differentiation  (IMP)
epithelial cell proliferation  (IGI,IMP)
epithelial cell proliferation involved in salivary gland morphogenesis  (IGI,IMP)
epithelial to mesenchymal transition  (ISO)
epithelial tube branching involved in lung morphogenesis  (IMP)
ERK1 and ERK2 cascade  (IGI)
fibroblast growth factor receptor signaling pathway  (IGI,IMP,ISO)
fibroblast growth factor receptor signaling pathway involved in hemopoiesis  (IMP)
fibroblast growth factor receptor signaling pathway involved in mammary gland specification  (IMP)
fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow cell  (IMP)
fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development  (IMP)
fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow  (IMP)
gland morphogenesis  (IMP)
hair follicle morphogenesis  (IMP)
in utero embryonic development  (IGI,IMP)
inner ear morphogenesis  (IMP)
lacrimal gland development  (IMP)
lateral sprouting from an epithelium  (IMP)
lens fiber cell development  (IGI,IMP)
limb bud formation  (IMP)
lung alveolus development  (IGI,IMP)
lung development  (IGI,IMP)
lung lobe morphogenesis  (IMP)
lung-associated mesenchyme development  (IGI,IMP)
mammary gland bud formation  (IMP)
membranous septum morphogenesis  (IMP)
mesenchymal cell differentiation  (IGI)
mesenchymal cell differentiation involved in lung development  (IGI)
mesenchymal cell proliferation  (IGI)
mesenchymal cell proliferation involved in lung development  (IMP)
mesodermal cell differentiation  (ISO)
midbrain development  (IGI)
mitotic nuclear division  (IGI)
morphogenesis of embryonic epithelium  (IMP)
negative regulation of epithelial cell proliferation  (IGI,ISO)
negative regulation of keratinocyte proliferation  (ISO)
negative regulation of mitotic nuclear division  (IGI)
negative regulation of transcription by RNA polymerase II  (IMP)
neuromuscular junction development  (IMP)
odontogenesis  (IMP)
orbitofrontal cortex development  (IMP)
organ growth  (IMP)
otic vesicle formation  (IMP,TAS)
outflow tract septum morphogenesis  (IMP)
peptidyl-tyrosine phosphorylation  (ISO)
phosphorylation  (IEA)
positive regulation of canonical Wnt signaling pathway  (IGI,IMP)
positive regulation of cardiac muscle cell proliferation  (IGI)
positive regulation of cell cycle  (IMP)
positive regulation of cell population proliferation  (IGI,IMP,ISO)
positive regulation of epithelial cell proliferation  (IGI,IMP)
positive regulation of epithelial cell proliferation involved in lung morphogenesis  (IMP)
positive regulation of ERK1 and ERK2 cascade  (IGI)
positive regulation of gene expression  (IMP)
positive regulation of kinase activity  (IBA)
positive regulation of MAPK cascade  (ISO)
positive regulation of mesenchymal cell proliferation  (IGI)
positive regulation of phospholipase activity  (ISO)
positive regulation of somatic stem cell division  (IMP)
positive regulation of stem cell proliferation  (IGI,IMP)
positive regulation of transcription by RNA polymerase II  (IMP)
positive regulation of urothelial cell proliferation  (IMP)
positive regulation of vascular associated smooth muscle cell proliferation  (ISO)
positive regulation of Wnt signaling pathway  (IMP)
post-embryonic development  (IMP)
prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis  (IMP)
prostate epithelial cord elongation  (IMP)
prostate gland morphogenesis  (IMP)
protein autophosphorylation  (ISO)
protein phosphorylation  (IEA)
pyramidal neuron development  (IMP)
regulation of epithelial cell proliferation  (IMP)
regulation of ERK1 and ERK2 cascade  (IMP)
regulation of morphogenesis of a branching structure  (IMP)
regulation of osteoblast proliferation  (IMP)
regulation of smooth muscle cell differentiation  (IMP)
regulation of smoothened signaling pathway  (IMP)
reproductive structure development  (IMP)
response to ethanol  (ISO)
response to lipopolysaccharide  (ISO)
somatic stem cell division  (IMP)
squamous basal epithelial stem cell differentiation involved in prostate gland acinus development  (IMP)
stem cell differentiation  (IGI)
stem cell proliferation  (IGI,IMP)
synaptic vesicle transport  (IMP)
transmembrane receptor protein tyrosine kinase signaling pathway  (IBA)
ureteric bud development  (IGI)
urothelial cell proliferation  (IMP)
vasculogenesis involved in coronary vascular morphogenesis  (TAS)
ventricular cardiac muscle tissue morphogenesis  (IMP)
ventricular zone neuroblast division  (IMP)
wound healing  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal adrenal gland development  (IAGP)
abnormal apical ectodermal ridge morphology  (IAGP)
abnormal appendicular skeleton morphology  (IAGP)
abnormal astrocyte morphology  (IAGP)
abnormal axial skeleton morphology  (IAGP)
abnormal basicranium morphology  (IAGP)
abnormal basioccipital bone morphology  (IAGP)
abnormal basisphenoid bone morphology  (IAGP)
abnormal bone ossification  (IAGP)
abnormal brain morphology  (IAGP)
abnormal brain size  (IAGP)
abnormal branching involved in seminal vesicle morphogenesis  (IAGP)
abnormal bronchiole morphology  (IAGP)
abnormal cartilage development  (IAGP)
abnormal cartilage morphology  (IAGP)
abnormal cecum development  (IAGP)
abnormal cerebral hemisphere morphology  (IAGP)
abnormal cervical vertebrae morphology  (IAGP)
abnormal chemokine level  (IAGP)
abnormal chondrocyte morphology  (IAGP)
abnormal clavicle morphology  (IAGP)
abnormal coat/ hair morphology  (IAGP)
abnormal cochlea morphology  (IAGP)
abnormal cochlear sensory epithelium morphology  (IAGP)
abnormal conotruncal ridge morphology  (IAGP)
abnormal coronal suture morphology  (IAGP)
abnormal corpus callosum morphology  (IAGP)
abnormal cranial cartilage development  (IAGP)
abnormal cranial cartilage morphology  (IAGP)
abnormal cranial cavity morphology  (IAGP)
abnormal cranial suture morphology  (IAGP)
abnormal cranial synchondrosis  (IAGP)
abnormal craniofacial bone morphology  (IAGP)
abnormal craniofacial morphology  (IAGP)
abnormal cranium morphology  (IAGP)
abnormal decidualization  (IAGP)
abnormal dermis papillary layer morphology  (IAGP)
abnormal developmental patterning  (IAGP)
abnormal digestive system morphology  (IAGP)
abnormal digestive system physiology  (IAGP)
abnormal ear development  (IAGP)
abnormal egg cylinder morphology  (IAGP)
abnormal embryo development  (IAGP)
abnormal endochondral bone ossification  (IAGP)
abnormal endoderm development  (IAGP)
abnormal endolymphatic duct morphology  (IAGP)
abnormal epidermal layer morphology  (IAGP)
abnormal epidermis stratum basale morphology  (IAGP)
abnormal epidermis stratum corneum morphology  (IAGP)
abnormal epidermis stratum granulosum morphology  (IAGP)
abnormal facial morphology  (IAGP)
abnormal frontal bone morphology  (IAGP)
abnormal hair cycle  (IAGP)
abnormal hair follicle development  (IAGP)
abnormal hair follicle morphology  (IAGP)
abnormal hair follicle orientation  (IAGP)
abnormal head morphology  (IAGP)
abnormal head shape  (IAGP)
abnormal heart development  (IAGP)
abnormal heart ventricle morphology  (IAGP)
abnormal ilium morphology  (IAGP)
abnormal intermaxillary suture morphology  (IAGP)
abnormal interparietal bone morphology  (IAGP)
abnormal interventricular groove morphology  (IAGP)
abnormal intestinal glucose absorption  (IAGP)
abnormal ischium morphology  (IAGP)
abnormal joint morphology  (IAGP)
abnormal keratinocyte morphology  (IAGP)
abnormal kidney cortex morphology  (IAGP)
abnormal kidney development  (IAGP)
abnormal lacrimal gland development  (IAGP)
abnormal lambdoid suture morphology  (IAGP)
abnormal lateral ganglionic eminence morphology  (IAGP)
abnormal lateral nasal gland morphology  (IAGP)
abnormal left posterior bundle morphology  (IAGP)
abnormal limb development  (IAGP)
abnormal liver development  (IAGP)
abnormal long bone epiphyseal ossification zone morphology  (IAGP)
abnormal long bone epiphyseal plate proliferative zone  (IAGP)
abnormal long bone epiphysis morphology  (IAGP)
abnormal long bone hypertrophic chondrocyte zone  (IAGP)
abnormal long bone metaphysis morphology  (IAGP)
abnormal lung development  (IAGP)
abnormal lung morphology  (IAGP)
abnormal mammary gland bud morphology  (IAGP)
abnormal mammary placode morphology  (IAGP)
abnormal mandible morphology  (IAGP)
abnormal mandibular angle morphology  (IAGP)
abnormal mast cell morphology  (IAGP)
abnormal maxillary frontal process morphology  (IAGP)
abnormal maxillary zygomatic process morphology  (IAGP)
abnormal maxillary-premaxillary suture morphology  (IAGP)
abnormal medial ganglionic eminence morphology  (IAGP)
abnormal membranous labyrinth morphology  (IAGP)
abnormal metanephric mesenchyme morphology  (IAGP)
abnormal midface morphology  (IAGP)
abnormal nail morphology  (IAGP)
abnormal nasal bone morphology  (IAGP)
abnormal nasal capsule morphology  (IAGP)
abnormal nasal gland morphology  (IAGP)
abnormal nasal septum cartilage morphology  (IAGP)
abnormal nasomaxillary suture morphology  (IAGP)
abnormal neurocranium morphology  (IAGP)
abnormal osteoblast differentiation  (IAGP)
abnormal osteoblast physiology  (IAGP)
abnormal osteoblast proliferation  (IAGP)
abnormal osteoclast differentiation  (IAGP)
abnormal otic capsule morphology  (IAGP)
abnormal otic vesicle development  (IAGP)
abnormal palatal mesenchymal cell proliferation  (IAGP)
abnormal palatal shelf fusion at midline  (IAGP)
abnormal palate development  (IAGP)
abnormal palate morphology  (IAGP)
abnormal palatine bone horizontal plate morphology  (IAGP)
abnormal palatine bone morphology  (IAGP)
abnormal pancreas development  (IAGP)
abnormal pelvic girdle bone morphology  (IAGP)
abnormal perineum morphology  (IAGP)
abnormal pituitary gland development  (IAGP)
abnormal placenta development  (IAGP)
abnormal placenta morphology  (IAGP)
abnormal placenta vasculature  (IAGP)
abnormal presphenoid bone morphology  (IAGP)
abnormal prostate gland branching morphogenesis  (IAGP)
abnormal pulmonary acinus morphology  (IAGP)
abnormal pulmonary circulation  (IAGP)
abnormal Rathke's pouch apoptosis  (IAGP)
abnormal Rathke's pouch development  (IAGP)
abnormal rectum morphology  (IAGP)
abnormal reproductive system physiology  (IAGP)
abnormal respiration  (IAGP)
abnormal right lung morphology  (IAGP)
abnormal sagittal suture morphology  (IAGP)
abnormal salivary gland morphology  (IAGP)
abnormal scapula morphology  (IAGP)
abnormal secondary palate development  (IAGP)
abnormal semicircular canal morphology  (IAGP)
abnormal seminal vesicle development  (IAGP)
abnormal seminal vesicle morphology  (IAGP)
abnormal seminal vesicle muscle layer morphology  (IAGP)
abnormal skeleton development  (IAGP)
abnormal skeleton physiology  (IAGP)
abnormal skin adnexa morphology  (IAGP)
abnormal skin appearance  (IAGP)
abnormal skin morphology  (IAGP)
abnormal small intestine crypts of Lieberkuhn morphology  (IAGP)
abnormal small intestine morphology  (IAGP)
abnormal sphenoid bone morphology  (IAGP)
abnormal sphenooccipital synchondrosis  (IAGP)
abnormal spongiotrophoblast layer morphology  (IAGP)
abnormal sternebra morphology  (IAGP)
abnormal sternum manubrium morphology  (IAGP)
abnormal sternum morphology  (IAGP)
abnormal sternum ossification  (IAGP)
abnormal stomach glandular region morphology  (IAGP)
abnormal stomach morphology  (IAGP)
abnormal submandibular duct morphology  (IAGP)
abnormal synaptic vesicle clustering  (IAGP)
abnormal synaptic vesicle number  (IAGP)
abnormal synchondrosis  (IAGP)
abnormal thoracic vertebrae morphology  (IAGP)
abnormal thymus development  (IAGP)
abnormal thymus morphology  (IAGP)
abnormal tongue morphology  (IAGP)
abnormal trabecula carnea morphology  (IAGP)
abnormal trabecular bone morphology  (IAGP)
abnormal tracheal cartilage morphology  (IAGP)
abnormal trophoblast layer morphology  (IAGP)
abnormal truncus arteriosus septation  (IAGP)
abnormal umbilical cord morphology  (IAGP)
abnormal ureteric bud elongation  (IAGP)
abnormal ureteric bud invasion  (IAGP)
abnormal ureteric bud morphology  (IAGP)
abnormal urethra morphology  (IAGP)
abnormal urethra urothelium morphology  (IAGP)
abnormal vascular development  (IAGP)
abnormal vasodilation  (IAGP)
abnormal vertebrae development  (IAGP)
abnormal vertebrae morphology  (IAGP)
abnormal vestibulocochlear ganglion morphology  (IAGP)
abnormal vibrissa number  (IAGP)
abnormal xiphoid process morphology  (IAGP)
abnormal zigzag hair morphology  (IAGP)
abnormal zygomatic arch morphology  (IAGP)
abnormal zygomatic bone morphology  (IAGP)
absent acromion  (IAGP)
absent adenohypophysis  (IAGP)
absent apical ectodermal ridge  (IAGP)
absent blastocoele  (IAGP)
absent exorbital lacrimal gland  (IAGP)
absent eyelids  (IAGP)
absent forelimb  (IAGP)
absent hair follicles  (IAGP)
absent hindlimb  (IAGP)
absent hypodermis muscle layer  (IAGP)
absent kidney  (IAGP)
absent lacrimal gland bud  (IAGP)
absent lacrimal glands  (IAGP)
absent limb buds  (IAGP)
absent limbs  (IAGP)
absent lungs  (IAGP)
absent mammary gland  (IAGP)
absent mast cells  (IAGP)
absent metanephric mesenchyme  (IAGP)
absent palatal rugae  (IAGP)
absent placental labyrinth  (IAGP)
absent presphenoid bone  (IAGP)
absent primitive endoderm  (IAGP)
absent pubis  (IAGP)
absent pulmonary artery  (IAGP)
absent pulmonary vein  (IAGP)
absent Rathke's pouch  (IAGP)
absent rectum  (IAGP)
absent sebaceous gland  (IAGP)
absent submandibular gland  (IAGP)
absent teeth  (IAGP)
absent telencephalon  (IAGP)
absent thyroid gland  (IAGP)
absent vertebral spinous process  (IAGP)
acanthosis  (IAGP)
adipose tissue inflammation  (IAGP)
aerophagia  (IAGP)
alopecia  (IAGP)
arrest of tooth development  (IAGP)
atelectasis  (IAGP)
atrium hypoplasia  (IAGP)
bronchiolectasis  (IAGP)
caudal vertebral fusion  (IAGP)
cecal atresia  (IAGP)
cervical vertebral fusion  (IAGP)
cleft palate  (IAGP)
cleft secondary palate  (IAGP)
conotruncal ridge hypoplasia  (IAGP)
curly tail  (IAGP)
decreased birth body size  (IAGP)
decreased birth weight  (IAGP)
decreased body length  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased bone mineral density  (IAGP)
decreased bone volume  (IAGP)
decreased brain size  (IAGP)
decreased cell proliferation  (IAGP)
decreased cranium height  (IAGP)
decreased cranium length  (IAGP)
decreased embryo size  (IAGP)
decreased fetal size  (IAGP)
decreased hair follicle number  (IAGP)
decreased inner canthal distance  (IAGP)
decreased kidney cell proliferation  (IAGP)
decreased molar number  (IAGP)
decreased nephron number  (IAGP)
decreased osteoblast cell number  (IAGP)
decreased osteoclast cell number  (IAGP)
decreased palatal length  (IAGP)
decreased prostate gland duct number  (IAGP)
decreased renal glomerulus number  (IAGP)
decreased sebaceous gland number  (IAGP)
decreased skin pigmentation  (IAGP)
decreased submandibular gland size  (IAGP)
decreased width of hypertrophic chondrocyte zone  (IAGP)
delayed bone ossification  (IAGP)
delayed cranial suture closure  (IAGP)
delayed intramembranous bone ossification  (IAGP)
dermatitis  (IAGP)
dilated distal convoluted tubule  (IAGP)
dilated heart atrium  (IAGP)
dilated proximal convoluted tubule  (IAGP)
disproportionate dwarf  (IAGP)
domed cranium  (IAGP)
double outlet right ventricle  (IAGP)
dry skin  (IAGP)
ectopic ureteric bud  (IAGP)
embryonic growth retardation  (IAGP)
embryonic lethality between implantation and somite formation, complete penetrance  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
enhanced osteoblast differentiation  (IAGP)
enlarged allantois  (IAGP)
enlarged fourth ventricle  (IAGP)
enlarged lateral ventricles  (IAGP)
epidermal cyst  (IAGP)
epidermal hyperplasia  (IAGP)
epidermis stratum granulosum hyperplasia  (IAGP)
epidermis stratum spinosum hyperplasia  (IAGP)
exophthalmos  (IAGP)
eyelids open at birth  (IAGP)
facial cleft  (IAGP)
failure of chorioallantoic fusion  (IAGP)
female infertility  (IAGP)
frontonasal prominence hypoplasia  (IAGP)
fused joints  (IAGP)
fused tracheal cartilage rings  (IAGP)
genital tubercle hypoplasia  (IAGP)
heart hypoplasia  (IAGP)
hydrocephaly  (IAGP)
hydronephrosis  (IAGP)
hypoglycemia  (IAGP)
hypospadia  (IAGP)
impaired branching involved in bronchus morphogenesis  (IAGP)
impaired branching involved in trachea morphogenesis  (IAGP)
impaired branching involved in ureteric bud morphogenesis  (IAGP)
impaired lung alveolus development  (IAGP)
impaired lung lobe morphogenesis  (IAGP)
impaired skin barrier function  (IAGP)
increased brain size  (IAGP)
increased cell death  (IAGP)
increased cranium height  (IAGP)
increased cranium width  (IAGP)
increased gamma-delta T cell number  (IAGP)
increased IgE level  (IAGP)
increased IgG1 level  (IAGP)
increased IgG2a level  (IAGP)
increased incidence of tumors by chemical induction  (IAGP)
increased keratinocyte proliferation  (IAGP)
increased kidney apoptosis  (IAGP)
increased mast cell number  (IAGP)
increased metanephric mesenchyme apoptosis  (IAGP)
increased osteoblast cell number  (IAGP)
increased osteoblast proliferation  (IAGP)
increased prostate gland weight  (IAGP)
increased skin papilloma incidence  (IAGP)
increased trophoblast giant cell number  (IAGP)
inner cell mass degeneration  (IAGP)
inner ear cyst  (IAGP)
lethality throughout fetal growth and development  (IAGP)
long incisors  (IAGP)
malocclusion  (IAGP)
meteorism  (IAGP)
microphthalmia  (IAGP)
midface hypoplasia  (IAGP)
muscular ventricular septal defect  (IAGP)
neonatal lethality  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
no abnormal phenotype detected  (IAGP)
ocular hypertelorism  (IAGP)
overriding aortic valve  (IAGP)
palatal shelf fusion with tongue or mandible  (IAGP)
palatal shelves fail to meet at midline  (IAGP)
parakeratosis  (IAGP)
parietal bossing  (IAGP)
perimembraneous ventricular septal defect  (IAGP)
perinatal lethality, complete penetrance  (IAGP)
perineal hypospadia  (IAGP)
polydipsia  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
premature coronal suture closure  (IAGP)
premature cranial suture closure  (IAGP)
premature death  (IAGP)
premature facial suture closure  (IAGP)
premature frontonasal suture closure  (IAGP)
premature intramembranous bone ossification  (IAGP)
premature lambdoid suture closure  (IAGP)
premature maxillary-premaxillary suture closure  (IAGP)
premature palatomaxillary suture closure  (IAGP)
premature presphenoid synchondrosis closure  (IAGP)
premature sphenooccipital synchondrosis closure  (IAGP)
premature squamoparietal suture closure  (IAGP)
premature zygomaticomaxillary suture closure  (IAGP)
primary sex reversal  (IAGP)
progressive hair loss  (IAGP)
pulmonary alveolar proteinosis  (IAGP)
pulmonary hypoplasia  (IAGP)
reduced male fertility  (IAGP)
respiratory distress  (IAGP)
respiratory failure  (IAGP)
sebaceous gland atrophy  (IAGP)
shallow orbits  (IAGP)
short basicranium  (IAGP)
short face  (IAGP)
short femur  (IAGP)
short frontal bone  (IAGP)
short humerus  (IAGP)
short mandible  (IAGP)
short maxilla  (IAGP)
short nasal bone  (IAGP)
short premaxilla  (IAGP)
short presphenoid bone  (IAGP)
short radius  (IAGP)
short rostral-caudal axis  (IAGP)
short snout  (IAGP)
short tibia  (IAGP)
short zygomatic arch  (IAGP)
short zygomatic bone  (IAGP)
shortened head  (IAGP)
skin fibrosis  (IAGP)
skin inflammation  (IAGP)
slow postnatal weight gain  (IAGP)
small cranium  (IAGP)
small face  (IAGP)
small frontal bone  (IAGP)
small hair follicles  (IAGP)
small kidney  (IAGP)
small lung  (IAGP)
small mandible  (IAGP)
small neurocranium  (IAGP)
small otic capsule  (IAGP)
small otic vesicle  (IAGP)
small pancreas  (IAGP)
small parietal bone  (IAGP)
small scapula  (IAGP)
small stomach  (IAGP)
small ureteric bud  (IAGP)
split sternal manubrium  (IAGP)
split sternum  (IAGP)
split xiphoid process  (IAGP)
submandibular gland hypoplasia  (IAGP)
syndactyly  (IAGP)
synostosis  (IAGP)
telencephalon hypoplasia  (IAGP)
thick epidermis  (IAGP)
thick nasal septum  (IAGP)
thin dermal layer  (IAGP)
thin epidermis  (IAGP)
thin frontal bone  (IAGP)
thin parietal bone  (IAGP)
thin skin  (IAGP)
thin ventricular wall  (IAGP)
tongue ankylosis  (IAGP)
translucent skin  (IAGP)
tremors  (IAGP)
ventricular hypoplasia  (IAGP)
vertebral fusion  (IAGP)
wide cranial sutures  (IAGP)
wide intermaxillary suture  (IAGP)
wide metopic suture  (IAGP)
wide sagittal suture  (IAGP)

References - curated
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77. Preclinical Combination Studies of an FGFR2 Targeted Thorium-227 Conjugate and the ATR Inhibitor BAY 1895344. Wickstroem K, etal., Int J Radiat Oncol Biol Phys. 2019 Oct 1;105(2):410-422. doi: 10.1016/j.ijrobp.2019.06.2508. Epub 2019 Jun 27.
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