Fabp2 (fatty acid binding protein 2, intestinal) - Rat Genome Database

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Gene: Fabp2 (fatty acid binding protein 2, intestinal) Mus musculus
Analyze
Symbol: Fabp2
Name: fatty acid binding protein 2, intestinal
RGD ID: 10564
MGI Page MGI
Description: Predicted to enable long-chain fatty acid binding activity and long-chain fatty acid transporter activity. Predicted to be involved in fatty acid metabolic process; intestinal lipid absorption; and long-chain fatty acid transport. Predicted to be located in apical cortex; microvillus; and plasma membrane. Predicted to be active in cytosol and nucleus. Is expressed in embryo endoderm; gut; liver and biliary system; and skeletal muscle. Human ortholog(s) of this gene implicated in alcoholic liver cirrhosis; carotid stenosis; coronary artery disease; end stage renal disease; and obesity. Orthologous to human FABP2 (fatty acid binding protein 2).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: Fa; Fabpi; fatty acid binding protein intestinal; fatty acid-binding protein 2; fatty acid-binding protein, intestinal; I-F; I-FABP; intestinal fatty acid binding protein 2; intestinal-type fatty acid-binding protein
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393122,688,721 - 122,693,155 (+)NCBIGRCm39mm39
GRCm39 Ensembl3122,688,721 - 122,693,155 (+)Ensembl
GRCm383122,895,072 - 122,899,506 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3122,895,072 - 122,899,506 (+)EnsemblGRCm38mm10GRCm38
MGSCv373122,598,310 - 122,602,424 (+)NCBIGRCm37mm9NCBIm37
MGSCv363122,887,414 - 122,891,528 (+)NCBImm8
Celera3129,305,754 - 129,309,868 (+)NCBICelera
Cytogenetic Map3G1NCBI
cM Map353.74NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Intestinal FABP2 A54T polymorphism: association with insulin resistance and obesity in women. Albala C, etal., Obes Res. 2004 Feb;12(2):340-5.
2. Cloning of a cDNA encoding rat intestinal fatty acid binding protein. Alpers DH, etal., Proc Natl Acad Sci U S A 1984 Jan;81(2):313-7.
3. An amino acid substitution in the human intestinal fatty acid binding protein is associated with increased fatty acid binding, increased fat oxidation, and insulin resistance. Baier LJ, etal., J Clin Invest 1995 Mar;95(3):1281-7.
4. The fatty acid-binding protein-2 A54T polymorphism is associated with renal disease in patients with type 2 diabetes. Canani LH, etal., Diabetes. 2005 Nov;54(11):3326-30.
5. The T 54 allele of the intestinal fatty acid-binding protein 2 is associated with a parental history of stroke. Carlsson M, etal., J Clin Endocrinol Metab 2000 Aug;85(8):2801-4.
6. Codon-54 polymorphism of the fatty acid-binding protein 2 gene is associated with elevation of fasting and postprandial triglyceride in type 2 diabetes. Georgopoulos A, etal., J Clin Endocrinol Metab 2000 Sep;85(9):3155-60.
7. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
8. Comparison of the acute response to meals enriched with cis- or trans-fatty acids on glucose and lipids in overweight individuals with differing FABP2 genotypes. Lefevre M, etal., Metabolism. 2005 Dec;54(12):1652-8.
9. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
10. MGDs mouse GO annotations MGD data from the GO Consortium
11. MGD IEA MGD IEA
12. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
13. Lack of association between the fatty acid binding protein 2 (FABP2) polymorphism with obesity and insulin resistance in two aboriginal populations from Chile. Perez-Bravo F, etal., Acta Diabetol. 2006 Dec;43(4):93-8.
14. Mouse MP Annotation Import Pipeline RGD automated import pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. The role of FABP2 gene polymorphism in alcoholic cirrhosis. Salguero ML, etal., Hepatol Res. 2005 Nov 8;.
18. The human and rodent intestinal fatty acid binding protein genes. A comparative analysis of their structure, expression, and linkage relationships. Sweetser DA, etal., J Biol Chem 1987 Nov 25;262(33):16060-71.
19. Thr54 allele of the FABP2 gene affects resting metabolic rate and visceral obesity. Takakura Y, etal., Diabetes Res Clin Pract. 2005 Jan;67(1):36-42.
20. Thr54 allele carriers of the Ala54Thr variant of FABP2 gene have associations with metabolic syndrome and hypertriglyceridemia in urban South Indians. Vimaleswaran KS, etal., Metabolism. 2006 Sep;55(9):1222-6.
21. Genetic variation of the intestinal fatty acid-binding protein 2 gene in carotid atherosclerosis. Wanby P, etal., Vasc Med. 2005 May;10(2):103-8.
22. Genetic risk for coronary artery disease in individuals with or without type 2 diabetes. Yamada Y, etal., Mol Genet Metab. 2004 Apr;81(4):282-90.
Additional References at PubMed
PMID:1527171   PMID:1617215   PMID:1739433   PMID:9203584   PMID:9277406   PMID:9494081   PMID:10349636   PMID:10608876   PMID:10725233   PMID:10786634   PMID:11023988   PMID:11042159  
PMID:11076861   PMID:11584097   PMID:11707574   PMID:11757913   PMID:12477932   PMID:15060137   PMID:15306695   PMID:15489334   PMID:15590741   PMID:15604097   PMID:15809042   PMID:16141072  
PMID:16141073   PMID:16882015   PMID:17485926   PMID:17905650   PMID:17983586   PMID:18186922   PMID:18369314   PMID:18653563   PMID:19389805   PMID:19801644   PMID:20015616   PMID:20043902  
PMID:20637749   PMID:20883684   PMID:21267068   PMID:21677750   PMID:21873635   PMID:22015720   PMID:22026722   PMID:22425624   PMID:22584290   PMID:22666383   PMID:22766025   PMID:23676500  
PMID:23990461   PMID:24496623   PMID:24929016   PMID:25122651   PMID:29684311   PMID:31345929   PMID:31905021   PMID:32298508  


Genomics

Comparative Map Data
Fabp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393122,688,721 - 122,693,155 (+)NCBIGRCm39mm39
GRCm39 Ensembl3122,688,721 - 122,693,155 (+)Ensembl
GRCm383122,895,072 - 122,899,506 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3122,895,072 - 122,899,506 (+)EnsemblGRCm38mm10GRCm38
MGSCv373122,598,310 - 122,602,424 (+)NCBIGRCm37mm9NCBIm37
MGSCv363122,887,414 - 122,891,528 (+)NCBImm8
Celera3129,305,754 - 129,309,868 (+)NCBICelera
Cytogenetic Map3G1NCBI
cM Map353.74NCBI
FABP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384119,317,250 - 119,322,138 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl4119,317,250 - 119,322,138 (-)EnsemblGRCh38hg38GRCh38
GRCh374120,238,405 - 120,243,293 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364120,457,853 - 120,462,766 (-)NCBINCBI36hg18NCBI36
Build 344120,596,008 - 120,600,921NCBI
Celera4117,600,001 - 117,604,911 (-)NCBI
Cytogenetic Map4q26NCBI
HuRef4115,960,235 - 115,965,143 (-)NCBIHuRef
CHM1_14120,214,972 - 120,219,883 (-)NCBICHM1_1
T2T-CHM13v2.04122,622,352 - 122,627,246 (-)NCBI
Fabp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22211,040,032 - 211,044,089 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl2211,040,032 - 211,044,089 (+)Ensembl
Rnor_6.02227,080,912 - 227,083,654 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2227,080,924 - 227,083,501 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02246,442,292 - 246,445,034 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42219,591,502 - 219,605,097 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12219,554,563 - 219,568,159 (+)NCBI
Celera2203,465,826 - 203,473,400 (+)NCBICelera
RH 3.4 Map21537.1RGD
Cytogenetic Map2q42NCBI
Fabp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542820,930,479 - 20,933,950 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542820,930,512 - 20,933,950 (+)NCBIChiLan1.0ChiLan1.0
FABP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.14122,055,544 - 122,060,461 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4122,055,544 - 122,060,461 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v04111,505,269 - 111,510,197 (-)NCBIMhudiblu_PPA_v0panPan3
FABP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13238,244,065 - 38,248,093 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
ROS_Cfam_1.03238,465,352 - 38,497,153 (-)NCBI
ROS_Cfam_1.0 Ensembl3238,465,346 - 38,492,684 (-)Ensembl
Fabp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530167,281,463 - 67,284,661 (+)NCBI
SpeTri2.0NW_004936869146,567 - 149,929 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FABP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8104,464,342 - 104,470,480 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18104,464,342 - 104,468,059 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28112,120,922 - 112,124,639 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FABP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1766,797,832 - 66,803,459 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl766,798,990 - 66,802,738 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603745,658,385 - 45,663,315 (-)NCBIVero_WHO_p1.0

Position Markers
Fabp2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm383122,899,280 - 122,899,405UniSTSGRCm38
MGSCv373122,602,198 - 122,602,323UniSTSGRCm37
Celera3129,309,642 - 129,309,767UniSTS
Cytogenetic Map3G1UniSTS
cM Map355.0UniSTS
M65034  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm383122,899,339 - 122,899,504UniSTSGRCm38
MGSCv373122,602,257 - 122,602,422UniSTSGRCm37
Celera3129,309,701 - 129,309,866UniSTS
Cytogenetic Map3G1UniSTS
cM Map355.0UniSTS
Whitehead_YAC3 UniSTS
D3Mit108  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm383122,898,771 - 122,899,085UniSTSGRCm38
MGSCv373122,601,689 - 122,602,003UniSTSGRCm37
Celera3129,309,133 - 129,309,447UniSTS
Cytogenetic Map3G1UniSTS
cM Map358.5UniSTS
Whitehead Genetic341.5UniSTS
D3Mit108.1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm383122,898,686 - 122,898,809UniSTSGRCm38
MGSCv373122,601,604 - 122,601,727UniSTSGRCm37
Celera3129,309,048 - 129,309,171UniSTS
Cytogenetic Map3G1UniSTS
cM Map358.5UniSTS
cM Map3 UniSTS
Whitehead Genetic341.5UniSTS
Whitehead_YAC3 UniSTS
Fabp2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map3G1UniSTS
Fabp2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm383122,898,758 - 122,899,404UniSTSGRCm38
MGSCv373122,601,676 - 122,602,322UniSTSGRCm37
Celera3129,309,120 - 129,309,766UniSTS
Cytogenetic Map3G1UniSTS
cM Map355.0UniSTS


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884436Zlq3_mzygomatic length QTL 3, 10 week (mouse)33265060142405761Mouse
13207570Tcq12_mtotal cholesterol QTL 12 (mouse)316504164130163649Mouse
1302056Orgwq4_morgan weight QTL 4 (mouse)Not determined330067588147304689Mouse
1301705Sles3_msystemic lupus erythmatosus suppressor 3 (mouse)Not determined337174862143353183Mouse
26884382Bzwq1_mbi-zygomatic width QTL 1, 5 week (mouse)352207421137205761Mouse
25314313Syncl1_msynaptonemal complex length 1 (mouse)367907333128393649Mouse
1357583Sle18_msystematic lupus erythematosus susceptibility 18 (mouse)Not determined387208904125316236Mouse
4142178Ctrq2_mC. trachomatis resistance QTL 2 (mouse)Not determined389139967137453008Mouse
10766455Sle22_msystematic lupus erythematosus susceptibility 22 (mouse)390376936124377072Mouse
14747001Mancz4_mmandible centroid size 4 (mouse)390378017124378017Mouse
1302052Etohcta4_methanol conditioned taste aversion 4 (mouse)Not determined391000105125008748Mouse
1301349Pgia26_mproteoglycan induced arthritis 26 (mouse)Not determined392251533126251650Mouse
27226732Tibmd3_mtibia midshaft diameter 3, 10 week (mouse)396607316147805636Mouse
10043955Wt10q4_mbody weight, 10 weeks, QTL 4 (mouse)Not determined398624041132624197Mouse
11533920Mvb3_mmodifier of vibrator 3 (mouse)398635284132635383Mouse
12792984Modn1_mmodifier of Dstn neovascularization 1 (mouse)398635284132635383Mouse
1302114Tbs1_mtuberculosis severity 1 (mouse)Not determined398924105132924250Mouse
1300752Ap6q_malcohol preference 6 QTL (mouse)Not determined3100372912147045722Mouse
26884419Bzwq6_mbi-zygomatic width QTL 6, 10 week (mouse)3100607316137205761Mouse
27226733Tibmd6_mtibia midshaft diameter 6, 16 week (mouse)3101307316149805637Mouse
1301805Mors2_mmodifier of obesity related sterility 2 (mouse)Not determined3103482659137482783Mouse
8655599Cia5c_mcollagen induced arthritis QTL 5c (mouse)Not determined3107376936125316237Mouse
1302093Orgwq5_morgan weight QTL 5 (mouse)Not determined3107376936147304689Mouse
1300619Cdcs1_mcytokine deficiency colitis susceptibility 1 (mouse)Not determined3109834882143835005Mouse
12910793Pwbwq7_mpost-weaning body weight QTL 7 (mouse)3110084357135715812Mouse
12910796Pwbwq6_mpost-weaning body weight QTL 6 (mouse)3110084357135715812Mouse
12910815Ogrq1_moverall growth rate QTL 1 (mouse)3110084357135715812Mouse
1301381Bomb1_mbone marrow pre-B 1 (mouse)Not determined3111133243145133417Mouse
1301100Bdt2_mbone density traits 2 (mouse)Not determined3114736617148736784Mouse
10043919Afpq8_mabdominal fat percent QTL 8 (mouse)Not determined3119057332153057456Mouse
1558868Ses9_msalmonella enteritidis susceptibility 9 (mouse)Not determined3119057332153057456Mouse
4141935Tgq15_mtriglyceride QTL 15 (mouse)Not determined119318586153318586Mouse
4142449Tgq14_mtriglyceride QTL 14 (mouse)Not determined119318586153318586Mouse
1302151Lprm2_mlymphoproliferation modifier 2 (mouse)Not determined3119778857153779044Mouse
10412240Alpq6_malcohol preference QTL 6 (mouse)Not determined3120772078154772078Mouse
12903998Cfq3_mconditioned fear QTL 3 (mouse)3122188811127220016Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:73
Count of miRNA genes:71
Interacting mature miRNAs:72
Transcripts:ENSMUST00000023820
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000023820   ⟹   ENSMUSP00000023820
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3122,688,721 - 122,693,155 (+)Ensembl
GRCm38.p6 Ensembl3122,895,072 - 122,899,506 (+)Ensembl
RefSeq Acc Id: NM_007980   ⟹   NP_032006
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393122,688,721 - 122,693,155 (+)NCBI
GRCm383122,895,072 - 122,899,506 (+)NCBI
MGSCv373122,598,310 - 122,602,424 (+)RGD
Celera3129,305,434 - 129,309,868 (+)NCBI
cM Map3 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_032006   ⟸   NM_007980
- UniProtKB: P55050 (UniProtKB/Swiss-Prot),   Q53YP5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000023820   ⟸   ENSMUST00000023820
Protein Domains
FABP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P55050-F1-model_v2 AlphaFold P55050 1-132 view protein structure

Promoters
RGD ID:6849634
Promoter ID:EP41010
Type:single initiation site
Name:MM_FABI
Description:Intestinal fatty-acid binding protein, FABP2 or FABPI gene.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Tissues & Cell Lines:gut
Experiment Methods:Primer extension with homologous sequence ladder
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv373122,598,296 - 122,598,356EPD
MGSCv363122,598,296 - 122,598,356EPD
RGD ID:6882264
Promoter ID:EPDNEW_M4583
Type:multiple initiation site
Name:Fabp2_1
Description:Mus musculus fatty acid binding protein 2, intestinal , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm383122,895,377 - 122,895,437EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:95478 AgrOrtholog
Ensembl Genes ENSMUSG00000023057 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000023820 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000023820 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.128.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Calycin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FABP2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fatty_acid-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ILBP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lipocln_cytosolic_FA-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:14079 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:95478 ENTREZGENE
NCBI Gene 14079 ENTREZGENE
PANTHER PTHR11955 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11955:SF89 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Lipocalin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Fabp2 PhenoGen
PRINTS FATTYACIDBP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE FABP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50814 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt FABPI_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q53YP5 ENTREZGENE, UniProtKB/TrEMBL