Esr2 (estrogen receptor 2 (beta)) - Rat Genome Database

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Gene: Esr2 (estrogen receptor 2 (beta)) Mus musculus
Symbol: Esr2
Name: estrogen receptor 2 (beta)
RGD ID: 10552
Description: Enables DNA binding activity. Acts upstream of or within several processes, including hormone-mediated signaling pathway; nervous system development; and reproductive structure development. Located in cytoplasm and nucleus. Is expressed in several structures, including brain; ganglia; genitourinary system; limb segment; and mammary gland primordium. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); bone disease (multiple); hypospadias; and neurodegenerative disease (multiple). Orthologous to human ESR2 (estrogen receptor 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ER beta; ER-beta; ER[b]; ERbe; ERbeta; Est; Estrb; estrogen receptor beta; nuclear receptor subfamily 3 group A member 2; oestrogen receptor beta
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391276,167,193 - 76,224,033 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1276,167,193 - 76,224,033 (-)EnsemblGRCm39 Ensembl
GRCm381276,120,419 - 76,177,259 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1276,120,419 - 76,177,259 (-)EnsemblGRCm38mm10GRCm38
MGSCv371277,221,406 - 77,278,246 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361277,039,259 - 77,096,099 (-)NCBIMGSCv36mm8
Celera1277,215,189 - 77,271,340 (-)NCBICelera
Cytogenetic Map12C3NCBI
cM Map1233.52NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
adenocarcinoma  (ISO)
adenoma  (ISO)
alopecia  (ISO)
Alzheimer's disease  (IEP,ISO)
Animal Mammary Neoplasms  (ISO)
anxiety disorder  (ISO)
aortic valve stenosis  (ISO)
asthma  (ISO)
atherosclerosis  (IDA)
atrial fibrillation  (ISO)
Blast Crisis  (IMP)
brain ischemia  (ISO)
breast cancer  (ISO)
Breast Neoplasms  (ISO)
carcinoma  (ISO)
Cardiac Arrhythmias  (ISO)
Cocaine-Related Disorders  (ISO)
Cognitive Dysfunction  (ISO)
colitis  (IEP,ISO)
colon cancer  (ISO)
colorectal cancer  (ISO)
Colorectal Neoplasms  (ISO)
contact dermatitis  (IMP)
coronary artery disease  (ISO)
Coronary Disease  (ISO)
Crohn's disease  (ISO)
cystitis  (ISO)
Deafness  (IMP)
Endometrial Neoplasms  (ISO)
endometriosis  (IDA,ISO)
Experimental Arthritis  (ISO)
Experimental Autoimmune Encephalomyelitis  (IDA,IMP)
Experimental Mammary Neoplasms  (ISO)
Experimental Melanoma  (IMP)
Female Infertility  (ISO)
glomerulosclerosis  (IEP)
Graves' disease  (ISO)
Hand Osteoarthritis  (ISO)
Hashimoto Disease  (ISO)
Hearing Loss  (IMP)
Hemorrhagic Shock  (ISO)
Hot Flashes  (ISO)
Hyperalgesia  (IMP,ISO)
hypertension  (IMP,ISO)
hypospadias  (ISO)
in situ carcinoma  (ISO)
inflammatory bowel disease  (ISO)
interstitial cystitis  (IMP)
Knee Osteoarthritis  (ISO)
Left Ventricular Hypertrophy  (IDA)
Lithiasis  (ISO)
Lung Injury  (ISO)
malignant astrocytoma  (ISO)
medulloblastoma  (ISO)
melanoma  (ISO)
mental depression  (ISO)
molybdenum cofactor deficiency type C  (ISO)
myasthenia gravis  (ISO)
myeloid leukemia  (IMP)
Myocardial Reperfusion Injury  (IMP)
obesity  (ISO)
osteoarthritis  (ISO)
osteoporosis  (IEP,ISO)
Osteoporotic Fractures  (ISO)
ovarian dysgenesis 8  (ISO)
Parkinson's disease  (ISO)
peritonitis  (ISO)
Pituitary Neoplasms  (ISO)
Postmenopausal Osteoporosis  (ISO)
pre-eclampsia  (ISO)
primary open angle glaucoma  (ISO)
prostate cancer  (ISO)
prostate carcinoma in situ  (ISO)
prostatic hypertrophy  (IDA)
Prostatic Neoplasms  (ISO)
pulmonary hypertension  (ISO)
retinal degeneration  (IMP)
rheumatoid arthritis  (ISO)
Sepsis  (ISO)
Spinal Cord Injuries  (ISO)
Splenomegaly  (IMP)
Stroke  (ISO)
systemic lupus erythematosus  (IDA,ISO)
systemic scleroderma  (ISO)
transient cerebral ischemia  (ISO)
transitional cell carcinoma  (ISO)
ulcerative colitis  (ISO)
urinary bladder cancer  (ISO)
Urination Disorders  (ISO)
Varicose Ulcer  (ISO)
Vulvar Lichen Sclerosus  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(24S)-24-hydroxycholesterol  (ISO)
(25R)-cholest-5-ene-3beta,26-diol  (EXP,ISO)
(3-phenoxyphenyl)methanol  (ISO)
(R,R,R)-alpha-tocopherol  (ISO)
(S)-naringenin  (EXP,ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP,ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,2-dimethylhydrazine  (EXP)
1-bromopropane  (EXP)
1-Hydroxypyrene  (ISO)
1-naphthol  (ISO)
10H-phenothiazine  (ISO)
16-Ketoestrone  (ISO)
17alpha-estradiol  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17alpha-hydroxyprogesterone  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
1H-pyrazole  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2'-Bisphenol F  (ISO)
2,2'-Dihydroxy-4-methoxybenzophenone  (ISO)
2,2,2-trichloroethanol  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (EXP)
2,3,4,5-Tetrachloro-4'-biphenylol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-bis(4-hydroxyphenyl)propionitrile  (EXP,ISO)
2,4,5-trichlorophenol  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dichlorophenol  (ISO)
2,4-Dihydroxybenzophenone  (ISO)
2,6-diisopropylnaphthalene  (ISO)
2,6-dimethylnaphthalene  (ISO)
2-hydroxy-17beta-estradiol  (ISO)
2-hydroxyestrone  (ISO)
2-tert-butylhydroquinone  (ISO)
2-tert-Butylphenol  (ISO)
22-Hydroxycholesterol  (ISO)
25-hydroxycholesterol  (ISO)
26-hydroxycholesterol  (EXP,ISO)
3',5'-cyclic AMP  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3,3'-diindolylmethane  (ISO)
3,3'-Dimethylbenzidine  (ISO)
3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-1-decanol  (ISO)
3,5,6-trichloro-2-pyridinol  (EXP)
3,5,6-trichloropyridine-2-one  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (EXP,ISO)
3-Methyl-4-(2,6,6-trimethyl-2-cyclohexen-1-yl)-3-buten-2-one  (ISO)
3-phenoxybenzoic acid  (EXP)
4'-epidoxorubicin  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4,4'-thiodiphenol  (ISO)
4-Androstenediol  (ISO)
4-chloro-3,5-dimethylphenol  (ISO)
4-ethylphenol  (EXP,ISO)
4-hydroxy-17beta-estradiol  (ISO)
4-Hydroxybenzophenone  (ISO)
4-nitro-m-cresol  (EXP)
4-nitrophenol  (ISO)
4-nitrotoluene  (ISO)
4-nonylphenol  (EXP,ISO)
4-octylphenol  (EXP,ISO)
4-Propylphenol  (EXP)
4-tert-butylphenol  (ISO)
4-tert-Octylphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5alpha-androstane-3alpha,17beta-diol  (ISO)
5alpha-androstane-3beta,17beta-diol  (ISO)
6-oxocampestanol  (ISO)
7,12-dimethyltetraphene  (ISO)
8-Br-cAMP  (ISO)
9-cis-retinoic acid  (ISO)
9-phenanthrol  (ISO)
acetochlor  (ISO)
acetophenone  (ISO)
acrylamide  (ISO)
adenosine  (EXP,ISO)
afimoxifene  (ISO)
aldehydo-D-glucose  (ISO)
aldrin  (ISO)
all-trans-phytoene  (ISO)
all-trans-phytofluene  (ISO)
all-trans-retinoic acid  (ISO)
alpha-hexachlorocyclohexane  (ISO)
alpha-naphthoflavone  (ISO)
alpha-Zearalanol  (ISO)
aluminium atom  (ISO)
aluminium(0)  (ISO)
ammonium chloride  (ISO)
androgen antagonist  (ISO)
androst-4-ene-3,17-dione  (ISO)
androst-5-ene-3beta,17beta-diol  (EXP,ISO)
androstane-3,17-diol  (ISO)
anilines  (ISO)
apigenin  (ISO)
Aroclor 1254  (EXP,ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
azadirachtin A  (EXP,ISO)
bazedoxifene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzophenone  (ISO)
benzyl benzoate  (ISO)
Benzyl parahydroxybenzoate  (ISO)
Benzyl salicylate  (ISO)
beta-carotene  (ISO)
beta-hexachlorocyclohexane  (EXP,ISO)
beta-naphthoflavone  (ISO)
beta-tocopherol  (ISO)
beta-Zearalanol  (ISO)
bexarotene  (ISO)
bicalutamide  (ISO)
bifenthrin  (ISO)
biochanin A  (EXP,ISO)
biphenyl-2-ol  (ISO)
biphenyl-4-ol  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
bortezomib  (ISO)
brassinolide  (ISO)
Bromofos  (ISO)
Bromophos-ethyl  (ISO)
butanal  (ISO)
butylated hydroxyanisole  (ISO)
butylbenzene  (ISO)
Butylbenzyl phthalate  (EXP,ISO)
Butylparaben  (ISO)
butyric acid  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
camptothecin  (ISO)
carbaryl  (ISO)
carbendazim  (ISO)
carbon nanotube  (EXP)
carfilzomib  (ISO)
cedrol  (ISO)
CGP 52608  (ISO)
chlordecone  (EXP,ISO)
chlorogenic acid  (ISO)
chloropropylate  (ISO)
chlorpyrifos  (EXP)
chlorpyrifos-methyl  (ISO)
chromium(6+)  (ISO)
chrysin  (ISO)
cisplatin  (ISO)
citral  (ISO)
clomiphene  (ISO)
colforsin daropate hydrochloride  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
coumaphos  (ISO)
coumestrol  (EXP,ISO)
Cuprizon  (ISO)
cyanazine  (ISO)
Cyanofenphos  (ISO)
cycloheximide  (ISO)
cyclophosphamide  (ISO)
cyhalothrin  (ISO)
cypermethrin  (EXP,ISO)
cyproterone acetate  (ISO)
D-aspartic acid  (EXP)
D-glucose  (ISO)
daidzein  (EXP,ISO)
daidzein 7-O-beta-D-glucoside  (ISO)
Decamethylcyclopentasiloxane  (ISO)
dehydroepiandrosterone  (ISO)
delta-hexachlorocyclohexane  (ISO)
delta-tocopherol  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP)
Di-n-hexyl phthalate  (ISO)
Di-n-octyl phthalate  (ISO)
diarsenic trioxide  (ISO)
diarylheptanoid  (ISO)
dibutyl phthalate  (EXP,ISO)
Dichlofenthion  (ISO)
dicofol  (ISO)
Dicyclohexyl phthalate  (ISO)
dieldrin  (EXP,ISO)
dienestrol  (ISO)
diethyl phthalate  (EXP,ISO)
diethylstilbestrol  (EXP,ISO)
digitoxin  (ISO)
diheptyl phthalate  (ISO)
diisobutyl phthalate  (ISO)
Diisodecyl phthalate  (EXP)
dimethoate  (EXP)
diniconazole  (ISO)
dioscin  (EXP,ISO)
diosgenin  (EXP)
dioxygen  (ISO)
dipentyl phthalate  (ISO)
diphenylmethanol  (ISO)
dipropyl phthalate  (ISO)
disodium selenite  (ISO)
diuron  (ISO)
doxorubicin  (ISO)
dronedarone  (ISO)
emetine  (ISO)
emodin  (ISO)
endosulfan  (EXP,ISO)
endrin  (ISO)
enilconazole  (EXP,ISO)
enzacamene  (ISO)
equilin  (ISO)
equol  (ISO)
estradiol  (ISO)
estriol  (EXP,ISO)
estrone  (EXP,ISO)
estrone 3-sulfate  (ISO)
ethanol  (ISO)
ethion  (ISO)
Ethyl cinnamate  (ISO)
ethyl myristate  (ISO)
ethylparaben  (ISO)
etoposide  (ISO)
eugenol  (ISO)
fenamiphos  (ISO)
fenarimol  (EXP,ISO)
fenbuconazole  (ISO)
fenhexamid  (ISO)
fenitrothion  (ISO)
fenpyroximate  (ISO)
fenthion  (ISO)
fentin chloride  (ISO)
fenvalerate  (ISO)
finasteride  (ISO)
fingolimod hydrochloride  (ISO)
fipronil  (ISO)
flavone  (ISO)
fludioxonil  (ISO)
fluoranthene  (ISO)
fluoxastrobin  (ISO)
flutamide  (EXP,ISO)
formononetin  (ISO)
fulvestrant  (EXP,ISO)
galaxolide  (ISO)
gamma-hexachlorocyclohexane  (ISO)
gamma-tocopherol  (ISO)
gefitinib  (ISO)
genistein  (EXP,ISO)
genistein 7-O-beta-D-glucoside  (ISO)
geranial  (ISO)
geraniol  (ISO)
glucose  (ISO)
glycitein  (ISO)
glycitin  (ISO)
glyphosate  (ISO)
heptachlor  (ISO)
Heptachlor epoxide  (ISO)
herbicide  (ISO)
hexachlorobenzene  (ISO)
hexestrol  (ISO)
hydrogencarbonate  (EXP)
hydroquinone O-beta-D-glucopyranoside  (EXP,ISO)
ICI-164384  (ISO)
indinavir  (EXP)
indoles  (EXP)
ipriflavone  (ISO)
iprodione  (ISO)
irilone  (ISO)
Isobutylparaben  (ISO)
isoflavones  (ISO)
Isopropylparaben  (ISO)
isorhamnetin  (ISO)
isotretinoin  (ISO)
kaempferol  (EXP,ISO)
kresoxim-methyl  (ISO)
L-ascorbic acid  (ISO)
lamivudine  (EXP)
lasofoxifene  (ISO)
leptophos  (ISO)
linuron  (ISO)
lipopolysaccharide  (EXP)
liquiritigenin  (ISO)
luteolin  (ISO)
lycopene  (ISO)
M1  (ISO)
mancozeb  (ISO)
melatonin  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
mestranol  (ISO)
metconazole  (ISO)
metformin  (ISO)
methimazole  (EXP)
methiocarb  (ISO)
methoxyacetic acid  (ISO)
methoxychlor  (EXP,ISO)
methyl laurate  (ISO)
Methyl palmitate  (ISO)
methylparaben  (ISO)
methylseleninic acid  (ISO)
methyltestosterone  (ISO)
metolachlor  (ISO)
mifepristone  (ISO)
Mitotane  (ISO)
MK 571  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
monobenzyl phthalate  (EXP,ISO)
monoethyl phthalate  (EXP)
Moxestrol  (ISO)
mycophenolic acid  (ISO)
N,N-diethyl-m-toluamide  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-butylbenzenesulfonamide  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
n-propyl gallate  (ISO)
Nafoxidine  (ISO)
nandrolone  (ISO)
Nandrolone decanoate  (ISO)
napropamide  (ISO)
naringin  (ISO)
nebivolol  (ISO)
Nonylphenol  (ISO)
norethisterone  (ISO)
Norethynodrel  (ISO)
notoginsenoside R1  (ISO)
nuarimol  (ISO)
O-Desmethylangolensin  (ISO)
octocrylene  (ISO)
ormeloxifene  (ISO)
oryzalin  (ISO)
Osajin  (ISO)
Oxadiazon  (ISO)
oxybenzone  (ISO)
p-tert-Amylphenol  (ISO)
p-tolualdehyde  (ISO)
paclitaxel  (ISO)
parathion-methyl  (ISO)
pendimethalin  (ISO)
perfluorododecanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
permethrin  (ISO)
phenanthrene  (ISO)
phenothrin  (ISO)
phloretin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phthalic acid  (ISO)
phytoestrogen  (ISO)
picoxystrobin  (ISO)
Pomiferin  (ISO)
potassium dichromate  (ISO)
prallethrin  (ISO)
prochloraz  (ISO)
procymidone  (ISO)
progesterone  (EXP,ISO)
propamocarb  (ISO)
propargite  (ISO)
propiconazole  (ISO)
propylparaben  (ISO)
propyzamide  (ISO)
prothiofos  (ISO)
pterostilbene  (EXP)
puerarin  (ISO)
pyrazoles  (ISO)
pyrene  (ISO)
pyridaben  (ISO)
quercetin  (ISO)
quinalphos  (ISO)
raloxifene  (EXP,ISO)
reactive oxygen species  (ISO)
resveratrol  (EXP,ISO)
Rhapontigenin  (ISO)
rifapentine  (ISO)
Rosavin  (ISO)
rotenone  (ISO)
royal jelly  (ISO)
rubitecan  (ISO)
rutin  (ISO)
salicylates  (ISO)
saquinavir  (EXP)
SB 203580  (ISO)
serpentine asbestos  (ISO)
silibinin  (ISO)
sodium arsenite  (EXP,ISO)
sodium hypochlorite  (ISO)
sophoraflavanone B  (ISO)
staurosporine  (ISO)
streptozocin  (EXP)
tamoxifen  (EXP,ISO)
teniposide  (ISO)
testosterone  (EXP,ISO)
Testosterone propionate  (ISO)
Tetrachlorobisphenol A  (ISO)
tetrachloromethane  (ISO)
tetrachlorvinphos  (ISO)
tetradifon  (ISO)
tetralin  (ISO)
tetramethrin  (ISO)
tibolone  (ISO)
tolclofos-methyl  (ISO)
topotecan  (ISO)
toremifene  (EXP,ISO)
toxaphene  (ISO)
trans-piceid  (EXP)
Tri-2-ethylhexyl trimellitate  (ISO)
tributylstannane  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
trifloxystrobin  (ISO)
trifluralin  (ISO)
trifluridine  (ISO)
trilostane  (EXP)
triphenyl phosphate  (ISO)
Triphenylethylene  (ISO)
triptonide  (EXP)
triticonazole  (ISO)
undecan-2-one  (ISO)
Urolithin A  (ISO)
valinomycin  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP,ISO)
vinyl carbamate  (EXP)
vitamin D  (ISO)
zearalenone  (EXP,ISO)
zidovudine  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
amygdala development  (ISO)
androgen receptor signaling pathway  (IMP)
behavioral fear response  (ISO)
brain development  (IMP)
cell population proliferation  (IGI)
cellular response to estradiol stimulus  (ISO)
cellular response to magnetism  (ISO)
cellular response to organic cyclic compound  (ISO)
cellular response to xenobiotic stimulus  (ISO)
cerebellum development  (ISO)
epithelial cell maturation involved in prostate gland development  (IMP)
epithelial cell proliferation  (IMP)
estrous cycle  (ISO)
female gonad development  (ISO)
hormone-mediated apoptotic signaling pathway  (IMP)
hypothalamus development  (ISO)
intracellular estrogen receptor signaling pathway  (IMP,ISO)
intracellular steroid hormone receptor signaling pathway  (IBA,ISO)
learning or memory  (ISO)
male gonad development  (ISO)
negative regulation of androgen receptor signaling pathway  (IMP)
negative regulation of behavior  (ISO)
negative regulation of cell death  (ISO)
negative regulation of cell population proliferation  (IGI)
negative regulation of epithelial cell proliferation  (IMP,ISO)
negative regulation of feeding behavior  (ISO)
negative regulation of neuron death  (ISO)
negative regulation of reactive oxygen species metabolic process  (ISO)
negative regulation of smooth muscle cell proliferation  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
neuron migration  (IMP)
ovarian follicle development  (IMP,ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of DNA-binding transcription factor activity  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of epidermal growth factor receptor signaling pathway  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
prostate gland development  (ISO)
prostate gland epithelium morphogenesis  (IMP)
regulation of cell population proliferation  (IMP)
regulation of DNA-templated transcription  (IEA)
regulation of neuron apoptotic process  (ISO)
regulation of transcription by RNA polymerase II  (IBA)
response to activity  (ISO)
response to bisphenol A  (ISO)
response to dexamethasone  (ISO)
response to estradiol  (ISO)
response to estrogen  (ISO)
response to ethanol  (ISO)
response to genistein  (ISO)
response to hormone  (ISO)
response to human chorionic gonadotropin  (ISO)
response to insecticide  (ISO)
response to nutrient levels  (ISO)
response to organic cyclic compound  (ISO)
response to salt  (ISO)
response to testosterone  (ISO)
response to water deprivation  (ISO)
response to xenobiotic stimulus  (ISO)
Sertoli cell development  (ISO)
Sertoli cell proliferation  (ISO)
uterus development  (IGI)
vagina development  (IGI)
vasodilation  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal astrocyte morphology  (IAGP)
abnormal auditory brainstem response  (IAGP)
abnormal B cell number  (IAGP)
abnormal behavior  (IAGP)
abnormal bone marrow cell number  (IAGP)
abnormal bone mineralization  (IAGP)
abnormal bone ossification  (IAGP)
abnormal class switch recombination  (IAGP)
abnormal cochlear IHC afferent innervation pattern  (IAGP)
abnormal colon goblet cell morphology  (IAGP)
abnormal cumulus oophorus morphology  (IAGP)
abnormal enterocyte apoptosis  (IAGP)
abnormal enterocyte morphology  (IAGP)
abnormal enterocyte physiology  (IAGP)
abnormal enterocyte proliferation  (IAGP)
abnormal estrous cycle  (IAGP)
abnormal excitatory postsynaptic potential  (IAGP)
abnormal germ cell morphology  (IAGP)
abnormal hair cycle catagen phase  (IAGP)
abnormal immunoglobulin level  (IAGP)
abnormal intercalated disk morphology  (IAGP)
abnormal large intestine crypts of Lieberkuhn morphology  (IAGP)
abnormal leukopoiesis  (IAGP)
abnormal liver morphology  (IAGP)
abnormal long bone epiphyseal plate morphology  (IAGP)
abnormal lung morphology  (IAGP)
abnormal lymphopoiesis  (IAGP)
abnormal mammary gland epithelium morphology  (IAGP)
abnormal mammary gland growth during lactation  (IAGP)
abnormal mammary gland growth during pregnancy  (IAGP)
abnormal muscle contractility  (IAGP)
abnormal muscle electrophysiology  (IAGP)
abnormal myocardial fiber morphology  (IAGP)
abnormal neocortex morphology  (IAGP)
abnormal nociception after inflammation  (IAGP)
abnormal ovarian follicle morphology  (IAGP)
abnormal ovary morphology  (IAGP)
abnormal pulmonary alveolus morphology  (IAGP)
abnormal response of heart to induced stress  (IAGP)
abnormal response to cardiac infarction  (IAGP)
abnormal response/metabolism to endogenous compounds  (IAGP)
abnormal rete testis morphology  (IAGP)
abnormal seminiferous tubule morphology  (IAGP)
abnormal Sertoli cell morphology  (IAGP)
abnormal sexual interaction  (IAGP)
abnormal somatosensory cortex morphology  (IAGP)
abnormal spatial learning  (IAGP)
abnormal stomach morphology  (IAGP)
abnormal substantia nigra morphology  (IAGP)
abnormal superovulation  (IAGP)
abnormal surfactant physiology  (IAGP)
abnormal synaptic plasticity  (IAGP)
abnormal tertiary ovarian follicle morphology  (IAGP)
abnormal urinary bladder morphology  (IAGP)
abnormal urinary bladder physiology  (IAGP)
abnormal urinary bladder urothelium morphology  (IAGP)
abnormal uterus weight  (IAGP)
abnormal vascular smooth muscle morphology  (IAGP)
abnormal vascular smooth muscle physiology  (IAGP)
abnormal vertebrae morphology  (IAGP)
absent corpus luteum  (IAGP)
absent mature ovarian follicles  (IAGP)
accelerated hair follicle regression  (IAGP)
anemia  (IAGP)
anovulation  (IAGP)
ascites  (IAGP)
asthenozoospermia  (IAGP)
astrocytosis  (IAGP)
cachexia  (IAGP)
cardiac hypertrophy  (IAGP)
colitis  (IAGP)
decreased aggression towards male mice  (IAGP)
decreased areal bone mineral density  (IAGP)
decreased body weight  (IAGP)
decreased bone mineral content  (IAGP)
decreased bone mineral density of femur  (IAGP)
decreased brain size  (IAGP)
decreased CD4-positive, alpha beta T cell number  (IAGP)
decreased CD8-positive, alpha-beta T cell number  (IAGP)
decreased chemical nociceptive threshold  (IAGP)
decreased circulating follicle stimulating hormone level  (IAGP)
decreased circulating glucose level  (IAGP)
decreased circulating insulin-like growth factor I level  (IAGP)
decreased circulating osteocalcin level  (IAGP)
decreased compact bone area  (IAGP)
decreased corpora lutea number  (IAGP)
decreased dopamine level  (IAGP)
decreased exploration in new environment  (IAGP)
decreased femoral compact bone area  (IAGP)
decreased insulin secretion  (IAGP)
decreased litter size  (IAGP)
decreased locomotor activity  (IAGP)
decreased male germ cell number  (IAGP)
decreased neuron number  (IAGP)
decreased ovulation rate  (IAGP)
decreased physiological sensitivity to xenobiotic  (IAGP)
decreased serotonin level  (IAGP)
decreased spleen weight  (IAGP)
decreased superovulation rate  (IAGP)
decreased theca cell number  (IAGP)
decreased uterus weight  (IAGP)
decreased vertical activity  (IAGP)
decreased volumetric bone mineral density  (IAGP)
delayed wound healing  (IAGP)
dilated heart ventricle  (IAGP)
dilated seminiferous tubule  (IAGP)
enlarged heart  (IAGP)
enlarged liver  (IAGP)
enlarged lymph nodes  (IAGP)
enlarged myocardial fiber  (IAGP)
enlarged pancreatic islets  (IAGP)
enlarged spleen  (IAGP)
failure of ejaculation  (IAGP)
failure of superovulation  (IAGP)
female infertility  (IAGP)
hyporesponsive to tactile stimuli  (IAGP)
impaired contextual conditioning behavior  (IAGP)
impaired cued conditioning behavior  (IAGP)
impaired granulosa cell differentiation  (IAGP)
impaired ovarian folliculogenesis  (IAGP)
increased aggression towards female mice  (IAGP)
increased aggression towards male mice  (IAGP)
increased anxiety-related response  (IAGP)
increased atretic ovarian follicle number  (IAGP)
increased body length  (IAGP)
increased body weight  (IAGP)
increased bone marrow cell number  (IAGP)
increased bone strength  (IAGP)
increased chronic myelocytic leukemia incidence  (IAGP)
increased circulating cholesterol level  (IAGP)
increased circulating glucose level  (IAGP)
increased circulating HDL cholesterol level  (IAGP)
increased circulating insulin-like growth factor I level  (IAGP)
increased circulating leptin level  (IAGP)
increased circulating luteinizing hormone level  (IAGP)
increased colon adenoma incidence  (IAGP)
increased compact bone area  (IAGP)
increased double-positive T cell number  (IAGP)
increased erythrocyte cell number  (IAGP)
increased gastrointestinal tumor incidence  (IAGP)
increased gonadal fat pad weight  (IAGP)
increased granulocyte number  (IAGP)
increased heart weight  (IAGP)
increased insulin sensitivity  (IAGP)
increased keratinocyte apoptosis  (IAGP)
increased leukocyte cell number  (IAGP)
increased megakaryocyte cell number  (IAGP)
increased monocyte cell number  (IAGP)
increased neutrophil cell number  (IAGP)
increased osteoblast cell number  (IAGP)
increased ovary tumor incidence  (IAGP)
increased pre-B cell number  (IAGP)
increased pro-B cell number  (IAGP)
increased retroperitoneal fat pad weight  (IAGP)
increased secondary ovarian follicle number  (IAGP)
increased sensitivity to induced morbidity/mortality  (IAGP)
increased systemic arterial blood pressure  (IAGP)
increased tertiary ovarian follicle number  (IAGP)
increased testis tumor incidence  (IAGP)
increased thigmotaxis  (IAGP)
increased total body fat amount  (IAGP)
increased urine glycosaminoglycan level  (IAGP)
increased vasoconstriction  (IAGP)
increased vasodilation  (IAGP)
insulin resistance  (IAGP)
long femur  (IAGP)
male infertility  (IAGP)
mammary gland alveolar hyperplasia  (IAGP)
myelofibrosis  (IAGP)
neuron degeneration  (IAGP)
no abnormal phenotype detected  (IEA)
obese  (IAGP)
oligozoospermia  (IAGP)
ovarian follicular cyst  (IAGP)
premature death  (IAGP)
prostate gland epithelial hyperplasia  (IAGP)
reduced female fertility  (IAGP)
reduced long term potentiation  (IAGP)
short femur  (IAGP)
short ulna  (IAGP)
small vagina  (IAGP)
spleen hyperplasia  (IAGP)
spleen hypoplasia  (IAGP)
thin epidermis  (IAGP)
thin uterus  (IAGP)
thymus hypoplasia  (IAGP)
urinary bladder inflammation  (IAGP)
uterus hypoplasia  (IAGP)
vagina hypoplasia  (IAGP)

References - curated
# Reference Title Reference Citation
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2. The effect of tamoxifen on bladder functions and histology, and the role of estrogen receptor beta in a rat chemical cystitis model. Acar D, etal., Neurourol Urodyn. 2007;26(2):309-16.
3. Polymorphisms spanning the 0N exon and promoter of the estrogen receptor-beta (ERbeta) gene ESR2 are associated with venous ulceration. Ashworth JJ, etal., Clin Genet. 2008 Jan;73(1):55-61. Epub 2007 Nov 29.
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5. Opposing roles of ERalpha and ERbeta in the genesis and progression of adenocarcinoma in the rat ventral prostate. Attia DM and Ederveen AG, Prostate. 2012 Jun 15;72(9):1013-22. doi: 10.1002/pros.21507. Epub 2011 Oct 24.
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12. Sequence variants of estrogen receptor beta and risk of prostate cancer in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium. Chen YC, etal., Cancer Epidemiol Biomarkers Prev. 2007 Oct;16(10):1973-81.
13. Effects of agonists for estrogen receptor alpha and beta on ovariectomy-induced lower urinary tract dysfunction in the rat. Cheng CL and de Groat WC, Am J Physiol Renal Physiol. 2014 Jan;306(2):F181-7. doi: 10.1152/ajprenal.00298.2013. Epub 2013 Nov 20.
14. Estrogen receptor-beta signaling protects epidermal cytokine expression and immune function from UVB-induced impairment in mice. Cho JL, etal., Photochem Photobiol Sci. 2008 Jan;7(1):120-5. doi: 10.1039/b709856a. Epub 2007 Nov 2.
15. Oestrogen receptor-beta signalling protects against transplanted skin tumour growth in the mouse. Cho JL, etal., Photochem Photobiol Sci. 2010 Apr;9(4):608-14. doi: 10.1039/b9pp00168a.
16. Callus formation is related to the expression ratios of estrogen receptors-alpha and -beta in ovariectomy-induced osteoporotic fracture healing. Chow SK, etal., Arch Orthop Trauma Surg. 2014 Oct;134(10):1405-16. doi: 10.1007/s00402-014-2070-0. Epub 2014 Aug 2.
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18. WAY-202196, a selective estrogen receptor-beta agonist, protects against death in experimental septic shock. Cristofaro PA, etal., Crit Care Med. 2006 Aug;34(8):2188-93.
19. Estrogen receptor expression in cutaneous melanoma: a real-time reverse transcriptase-polymerase chain reaction and immunohistochemical study. de Giorgi V, etal., Arch Dermatol. 2009 Jan;145(1):30-6. doi: 10.1001/archdermatol.2008.537.
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22. Estrogen receptor hormone agonists limit trauma hemorrhage shock-induced gut and lung injury in rats. Doucet D, etal., PLoS One. 2010 Feb 25;5(2):e9421.
23. Estrogen receptor-beta ligand treatment modulates dendritic cells in the target organ during autoimmune demyelinating disease. Du S, etal., Eur J Immunol. 2011 Jan;41(1):140-50. doi: 10.1002/eji.201040796. Epub 2010 Dec 9.
24. Estradiol modulates bcl-2 in cerebral ischemia: a potential role for estrogen receptors. Dubal DB, etal., J Neurosci. 1999 Aug 1;19(15):6385-93.
25. Quantitative analysis of estrogen receptor-alpha and -beta messenger RNA expression in normal and malignant thyroid tissues by real-time polymerase chain reaction. Egawa C, etal., Oncology. 2001;61(4):293-8.
26. Estrogen receptor beta protects against in vivo injury in RPE cells. Elliot SJ, etal., Exp Eye Res. 2010 Jan;90(1):10-6. doi: 10.1016/j.exer.2009.09.001. Epub 2009 Sep 30.
27. Sex-dependent association of blood pressure with oestrogen receptor genes ERalpha and ERbeta. Ellis JA, etal., J Hypertens. 2004 Jun;22(6):1127-31.
28. Organ messenger ribonucleic acid and plasma proteome changes in the adjuvant-induced arthritis model: responses to disease induction and therapy with the estrogen receptor-beta selective agonist ERB-041. Follettie MT, etal., Endocrinology. 2006 Feb;147(2):714-23. Epub 2005 Nov 3.
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30. Polymorphisms in estrogen-metabolizing and estrogen receptor genes and the risk of developing breast cancer among a cohort of women with benign breast disease. Gallicchio L, etal., BMC Cancer. 2006 Jun 29;6:173.
31. Association of CA repeat polymorphism in estrogen receptor beta gene with postmenopausal osteoporosis in Chinese. Geng L, etal., J Genet Genomics. 2007 Oct;34(10):868-76.
32. Aromatase inhibition exacerbates pain and reactive gliosis in the dorsal horn of the spinal cord of female rats caused by spinothalamic tract injury. Ghorbanpoor S, etal., Endocrinology. 2014 Nov;155(11):4341-55. doi: 10.1210/en.2014-1158. Epub 2014 Aug 8.
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34. Estrogen receptor genotypes and haplotypes associated with breast cancer risk. Gold B, etal., Cancer Res. 2004 Dec 15;64(24):8891-900.
35. Evaluation of an estrogen receptor-beta agonist in animal models of human disease. Harris HA, etal., Endocrinology. 2003 Oct;144(10):4241-9.
36. A selective estrogen receptor-beta agonist causes lesion regression in an experimentally induced model of endometriosis. Harris HA, etal., Hum Reprod. 2005 Apr;20(4):936-41. Epub 2004 Dec 23.
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39. Oestrogen receptor-beta CA repeat polymorphism is associated with incidence of colorectal cancer among females. Honma N, etal., Histopathology. 2011 Aug;59(2):216-24. doi: 10.1111/j.1365-2559.2011.03914.x.
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42. CYP2D6 and tamoxifen: DNA matters in breast cancer. Hoskins JM, etal., Nat Rev Cancer. 2009 Aug;9(8):576-86.
43. [The expression of estrogen receptor alpha and beta in the intervention of different estrogens in rat bone metabolism]. Hou NN, etal., Fen Zi Xi Bao Sheng Wu Xue Bao. 2006 Aug;39(4):289-96.
44. Upregulation of mitochondrial respiratory complex IV by estrogen receptor-beta is critical for inhibiting mitochondrial apoptotic signaling and restoring cardiac functions following trauma-hemorrhage. Hsieh YC, etal., J Mol Cell Cardiol. 2006 Sep;41(3):511-21. Epub 2006 Jul 21.
45. Estrogen receptor beta-deficient female mice develop a bladder phenotype resembling human interstitial cystitis. Imamov O, etal., Proc Natl Acad Sci U S A. 2007 Jun 5;104(23):9806-9. Epub 2007 May 23.
46. Estrogen receptor expression by peripheral blood mononuclear cells of patients with systemic lupus erythematosus. Inui A, etal., Clin Rheumatol. 2007 Oct;26(10):1675-8. Epub 2007 Feb 16.
47. Estrogen receptor-beta expression and pharmacological targeting in bladder cancer. Kauffman EC, etal., Oncol Rep. 2013 Jul;30(1):131-8. doi: 10.3892/or.2013.2416. Epub 2013 Apr 23.
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52. Estrogen receptor beta and oxytocin interact to modulate anxiety-like behavior and neuroendocrine stress reactivity in adult male and female rats. Kudwa AE, etal., Physiol Behav. 2014 Apr 22;129:287-96. doi: 10.1016/j.physbeh.2014.03.004. Epub 2014 Mar 13.
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54. T-1213C polymorphism of estrogen receptor beta is associated with low bone mineral density and osteoporotic fractures. Kung AW, etal., Bone. 2006 Nov;39(5):1097-106. Epub 2006 Jun 13.
55. A Western blot and molecular genetic investigation of the estrogen receptor beta in giant cell arteritis. Larsson K, etal., Clin Exp Rheumatol. 2006 Mar-Apr;24(2 Suppl 41):S17-9.
56. An estrogen receptor-beta agonist is active in models of inflammatory and chemical-induced pain. Leventhal L, etal., Eur J Pharmacol. 2006 Dec 28;553(1-3):146-8. Epub 2006 Sep 26.
57. Effects of estrogen receptor subtype-selective agonists on autoimmune disease in lupus-prone NZB/NZW F1 mouse model. Li J and McMurray RW, Clin Immunol. 2007 May;123(2):219-26. Epub 2007 Mar 1.
58. Ablation of estrogen receptor alpha or beta eliminates sex differences in mechanical pain threshold in normal and inflamed mice. Li L, etal., Pain. 2009 May;143(1-2):37-40. doi: 10.1016/j.pain.2009.01.005. Epub 2009 Mar 13.
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60. 17beta-estradiol induces the translocation of the estrogen receptors ESR1 and ESR2 to the cell membrane, MAPK3/1 phosphorylation and proliferation of cultured immature rat Sertoli cells. Lucas TF, etal., Biol Reprod. 2008 Jan;78(1):101-14. Epub 2007 Oct 10.
61. Estrogen receptor beta gene (ESRbeta) 3'-UTR variants in Alzheimer disease. Luckhaus C, etal., Alzheimer Dis Assoc Disord. 2006 Oct-Dec;20(4):322-3.
62. Estrogen receptor beta gene polymorphism and intraocular pressure elevation in female patients with primary open-angle glaucoma. Mabuchi F, etal., Am J Ophthalmol. 2010 May;149(5):826-30.e1-2. doi: 10.1016/j.ajo.2009.12.030.
63. Estrogen receptor alpha/beta ratio and estrogen receptor beta as predictors of endocrine therapy responsiveness-a randomized neoadjuvant trial comparison between anastrozole and tamoxifen for the treatment of postmenopausal breast cancer. Madeira M, etal., BMC Cancer. 2013 Sep 18;13:425. doi: 10.1186/1471-2407-13-425.
64. Impact of estrogen receptor beta activation on functional recovery after experimental stroke. Madinier A, etal., Behav Brain Res. 2014 Mar 15;261:282-8. doi: 10.1016/j.bbr.2013.12.046. Epub 2014 Jan 6.
65. Estrogen receptor beta (ESR2) polymorphisms in familial and sporadic breast cancer. Maguire P, etal., Breast Cancer Res Treat. 2005 Nov;94(2):145-52.
66. Simultaneous disruption of estrogen receptor and Wnt/beta-catenin signaling is involved in methyl amooranin-mediated chemoprevention of mammary gland carcinogenesis in rats. Mandal A, etal., Mol Cell Biochem. 2013 Sep 29.
67. Genetic polymorphisms of estrogen receptors in patients with premature coronary artery disease. Mansur Ade P, etal., Arch Med Res. 2005 Sep-Oct;36(5):511-7.
68. Association study using single nucleotide polymorphisms in the estrogen receptor beta (ESR2) gene for preeclampsia. Maruyama A, etal., Hypertens Res. 2004 Dec;27(12):903-9.
69. Novel ligands balance estrogen receptor beta and alpha agonism for safe and effective suppression of the vasomotor response in the ovariectomized female rat model of menopause. McGregor