Epor (erythropoietin receptor) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Epor (erythropoietin receptor) Mus musculus
Analyze
Symbol: Epor
Name: erythropoietin receptor
RGD ID: 10532
MGI Page MGI
Description: Enables erythropoietin receptor activity. Involved in erythropoietin-mediated signaling pathway. Acts upstream of or within several processes, including brain development; decidualization; and heart development. Is active in plasma membrane. Is expressed in several structures, including egg cylinder; embryo mesenchyme; genitourinary system; germ layer; and heart and pericardium. Used to study familial erythrocytosis 1. Human ortholog(s) of this gene implicated in anemia; familial erythrocytosis 1; high grade glioma; polycythemia; and systemic lupus erythematosus. Orthologous to human EPOR (erythropoietin receptor).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: EPO-R
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39921,870,193 - 21,874,915 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl921,870,193 - 21,874,802 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38921,958,897 - 21,963,576 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl921,958,897 - 21,963,506 (-)Ensemblmm10GRCm38
MGSCv37921,763,343 - 21,768,020 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36921,709,306 - 21,713,878 (-)NCBIMGSCv36mm8
Celera919,228,327 - 19,233,004 (-)NCBICelera
Cytogenetic Map9A3NCBI
cM Map97.93NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
1-chloro-2,4-dinitrobenzene  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-di-tert-butyl-4-methylphenol  (EXP)
2,6-dinitrotoluene  (ISO)
2-butoxyethanol  (EXP)
3,4-methylenedioxymethamphetamine  (EXP)
4,4'-sulfonyldiphenol  (EXP)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (EXP)
5-fluorouracil  (EXP)
acetamide  (ISO)
all-trans-retinoic acid  (ISO)
aluminium atom  (ISO)
aluminium(0)  (ISO)
ammonium chloride  (ISO)
amphotericin B  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
aristolochic acids  (ISO)
arsenous acid  (ISO)
bafilomycin A1  (ISO)
benzene  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (ISO)
BQ 123  (ISO)
C60 fullerene  (ISO)
cadmium dichloride  (ISO)
capsaicin  (EXP)
carbon nanotube  (EXP)
chlorpyrifos  (EXP)
chrysene  (EXP)
cisplatin  (ISO)
clofibrate  (EXP)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (EXP)
DDE  (ISO)
diarsenic trioxide  (ISO)
dicrotophos  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
enalapril  (ISO)
endosulfan  (ISO)
entinostat  (ISO)
ethanol  (ISO)
formaldehyde  (EXP)
gefitinib  (ISO)
genistein  (ISO)
GSK-J4  (ISO)
hydrogen peroxide  (ISO)
kainic acid  (ISO)
lidocaine  (ISO)
lipopolysaccharide  (EXP,ISO)
methamphetamine  (ISO)
methylmercury chloride  (ISO)
monosodium L-glutamate  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
nickel dichloride  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
paracetamol  (EXP)
perfluorohexanesulfonic acid  (EXP)
phenylhydrazine  (EXP)
phosphane  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
sodium arsenate  (ISO)
streptozocin  (ISO)
tamoxifen  (ISO)
tetraphene  (EXP)
toluene 2,4-diisocyanate  (EXP)
topotecan  (ISO)
Tributyltin oxide  (EXP)
trichloroethene  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (EXP)
triphenyl phosphate  (ISO)
triptonide  (EXP)
troglitazone  (EXP)
uranium atom  (ISO)
valproic acid  (ISO)
vincristine  (ISO)
wortmannin  (ISO)
zidovudine  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal blood vessel morphology  (IAGP)
abnormal embryonic erythrocyte morphology  (IAGP)
abnormal erythrocyte morphology  (IAGP)
abnormal erythropoiesis  (IAGP)
abnormal heart development  (IAGP)
abnormal heart morphology  (IAGP)
abnormal heart right ventricle pressure  (IAGP)
abnormal interventricular groove morphology  (IAGP)
abnormal interventricular septum morphology  (IAGP)
abnormal liver morphology  (IAGP)
abnormal lung vasculature morphology  (IAGP)
abnormal myocardial fiber physiology  (IAGP)
abnormal physiological neovascularization  (IAGP)
abnormal placenta morphology  (IAGP)
abnormal postnatal subventricular zone morphology  (IAGP)
abnormal proerythroblast morphology  (IAGP)
abnormal response to injury  (IAGP)
abnormal retina outer plexiform layer morphology  (IAGP)
abnormal stress erythropoiesis  (IAGP)
abnormal vascular endothelial cell migration  (IAGP)
absent erythroid progenitor cell  (IAGP)
anemia  (IAGP)
anisocytosis  (IAGP)
decreased a-wave amplitude  (IAGP)
decreased amacrine cell number  (IAGP)
decreased angiogenesis  (IAGP)
decreased b-wave amplitude  (IAGP)
decreased embryo size  (IAGP)
decreased erythrocyte cell number  (IAGP)
decreased fetal derived definitive erythrocyte cell number  (IAGP)
decreased hematocrit  (IAGP)
decreased hemoglobin content  (IAGP)
decreased interleukin-6 secretion  (IAGP)
decreased physiological sensitivity to xenobiotic  (IAGP)
decreased retina rod cell number  (IAGP)
decreased spleen weight  (IAGP)
decreased susceptibility to injury  (IAGP)
decreased total retina thickness  (IAGP)
detached epicardium  (IAGP)
edema  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
embryonic lethality, complete penetrance  (IAGP)
heart right ventricle hypertrophy  (IAGP)
impaired hematopoiesis  (IAGP)
increased amacrine cell number  (IAGP)
increased circulating erythropoietin level  (IAGP)
increased erythrocyte cell number  (IAGP)
increased erythroid progenitor cell number  (IAGP)
increased hematocrit  (IAGP)
increased hemoglobin content  (IAGP)
increased hepatocyte apoptosis  (IAGP)
increased susceptibility to induced morbidity/mortality  (IAGP)
lethality throughout fetal growth and development, complete penetrance  (IAGP)
liver hypoplasia  (IAGP)
microcytosis  (IAGP)
no abnormal phenotype detected  (IAGP)
pale liver  (IAGP)
pale yolk sac  (IAGP)
pericardial edema  (IAGP)
polychromatophilia  (IAGP)
polycythemia  (IAGP)
preweaning lethality, complete penetrance  (IAGP)
pulmonary hypertension  (IAGP)
reticulocytopenia  (IAGP)
reticulocytosis  (IAGP)
small liver  (IAGP)
thick ventricular wall  (IAGP)
thin retina inner plexiform layer  (IAGP)
thin retina outer plexiform layer  (IAGP)
ventricular hypoplasia  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Familial erythrocytosis associated with a short deletion in the erythropoietin receptor gene. Arcasoy MO, etal., Blood. 1997 Jun 15;89(12):4628-35.
2. A novel mutation in the erythropoietin receptor gene is associated with familial erythrocytosis. Arcasoy MO, etal., Blood. 2002 Apr 15;99(8):3066-9.
3. Functional significance of erythropoietin receptor expression in breast cancer. Arcasoy MO, etal., Lab Invest. 2002 Jul;82(7):911-8.
4. Brain erythropoietin receptor expression in Alzheimer disease and mild cognitive impairment. Assaraf MI, etal., J Neuropathol Exp Neurol. 2007 May;66(5):389-98.
5. Selective expression of mRNA coding for the truncated form of erythropoietin receptor in hematopoietic cells and its decrease in patients with polycythemia vera. Chiba S, etal., Blood. 1997 Jul 1;90(1):97-104.
6. Truncated erythropoietin receptor causes dominantly inherited benign human erythrocytosis. de la Chapelle A, etal., Proc Natl Acad Sci U S A. 1993 May 15;90(10):4495-9.
7. Mouse model of congenital polycythemia: Homologous replacement of murine gene by mutant human erythropoietin receptor gene. Divoky V, etal., Proc Natl Acad Sci U S A 2001 Jan 30;98(3):986-91.
8. Up-regulated endogenous erythropoietin/erythropoietin receptor system and exogenous erythropoietin rescue retinal ganglion cells after chronic ocular hypertension. Fu QL, etal., Cell Mol Neurobiol. 2008 Feb;28(2):317-29. Epub 2007 Jun 7.
9. Erythropoietin and erythropoietin receptor expression after experimental spinal cord injury encourages therapy by exogenous erythropoietin. Grasso G, etal., Neurosurgery. 2005 Apr;56(4):821-7; discussion 821-7.
10. Autoantibodies to erythropoietin receptor in patients with immune-mediated diseases: relationship to anaemia with erythroid hypoplasia. Hara A, etal., Br J Haematol. 2013 Jan;160(2):244-50. doi: 10.1111/bjh.12105. Epub 2012 Nov 15.
11. Erythropoietin improves motor and cognitive deficit, axonal pathology, and neuroinflammation in a combined model of diffuse traumatic brain injury and hypoxia, in association with upregulation of the erythropoietin receptor. Hellewell SC, etal., J Neuroinflammation. 2013 Dec 18;10:156. doi: 10.1186/1742-2094-10-156.
12. Down-Regulation of Cardiac Erythropoietin Receptor and its Downstream Activated Signal Transducer Phospho-STAT-5 in a Rat Model of Chronic Kidney Disease. Hertzberg-Bigelman E, etal., Isr Med Assoc J. 2016 Jun;18(6):326-30.
13. Hypertension induced by erythropoietin has a correlation with truncated erythropoietin receptor mRNA in endothelial progenitor cells of hemodialysis patients. Ioka T, etal., Clin Pharmacol Ther. 2009 Aug;86(2):154-9. doi: 10.1038/clpt.2009.74. Epub 2009 May 20.
14. The erythropoietin receptor gene is not linked with the polycythemia phenotype in a family with autosomal dominant primary polycythemia. Kralovics R, etal., Proc Assoc Am Physicians. 1997 Nov;109(6):580-5.
15. Protective effects of erythropoietin on myocardial infarction in rats: the role of AMP-activated protein kinase signaling pathway. Li XJ, etal., Am J Med Sci. 2011 Aug;342(2):153-9. doi: 10.1097/MAJ.0b013e318210041d.
16. Recombinant human erythropoietin administration protects cortical neurons from traumatic brain injury in rats. Liao ZB, etal., Eur J Neurol. 2008 Feb;15(2):140-9. Epub 2007 Dec 18.
17. [Influence of HIF- 2α on the expression of GATA- 1 in bone marrow CD71(+) cell of high altitude polycythemia rat model]. Liu F, etal., Zhonghua Xue Ye Xue Za Zhi. 2016 Aug 14;37(8):696-701. doi: 10.3760/cma.j.issn.0253-2727.2016.08.013.
18. Erythropoietin pretreatment exerts anti-inflammatory effects in hepatic ischemia/reperfusion-injured rats via suppression of the TLR2/NF-κB pathway. Liu QS, etal., Transplant Proc. 2015 Mar;47(2):283-9. doi: 10.1016/j.transproceed.2014.10.045.
19. Both megakaryocytopoiesis and erythropoiesis are induced in mice infected with a retrovirus expressing an oncogenic erythropoietin receptor. Longmore GD, etal., Blood. 1993 Oct 15;82(8):2386-95.
20. Anti-erythropoietin receptor antibodies in systemic lupus erythematosus patients with anemia. Luo XY, etal., Lupus. 2013 Feb;22(2):121-7. doi: 10.1177/0961203312463980. Epub 2012 Oct 18.
21. Recovery of motor spontaneous activity after intranasal delivery of human recombinant erythropoietin in a focal brain hypoxia model induced by CoCl2 in rats. Merelli A, etal., Neurotox Res. 2011 Aug;20(2):182-92. doi: 10.1007/s12640-010-9233-8. Epub 2010 Nov 30.
22. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
23. MGDs mouse GO annotations MGD data from the GO Consortium
24. MGD IEA MGD IEA
25. Characterization of the erythropoietin/erythropoietin receptor axis in a rat model of liver damage and cholangiocarcinoma development. Moriconi F, etal., Histochem Cell Biol. 2013 Mar;139(3):473-85. doi: 10.1007/s00418-012-1037-x. Epub 2012 Oct 4.
26. Impaired erythropoiesis in transgenic mice overexpressing a truncated erythropoietin receptor. Nakamura Y, etal., Exp Hematol. 1998 Nov;26(12):1105-10.
27. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
28. Targeting the erythropoietin receptor on glioma cells reduces tumour growth. Peres EA, etal., Exp Cell Res. 2011 Oct 1;317(16):2321-32. doi: 10.1016/j.yexcr.2011.06.011. Epub 2011 Jun 30.
29. EPO receptor gain-of-function causes hereditary polycythemia, alters CD34 cell differentiation and increases circulating endothelial precursors. Perrotta S, etal., PLoS One. 2010 Aug 5;5(8):e12015. doi: 10.1371/journal.pone.0012015.
30. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
31. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
32. Mouse MP Annotation Import Pipeline RGD automated import pipeline
33. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
34. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
35. Changes in CNS cells in hyperammonemic portal hypertensive rats. Tallis S, etal., J Neurochem. 2014 Feb;128(3):431-44. doi: 10.1111/jnc.12458. Epub 2013 Oct 24.
36. Permanent focal cerebral ischemia activates erythropoietin receptor in the neonatal rat brain. Wen TC, etal., Neurosci Lett. 2004 Jan 30;355(3):165-8.
37. Expression pattern of erythropoietin and erythropoietin receptor in experimental model of retinal detachment. Xie Z, etal., Curr Eye Res. 2007 Sep;32(9):757-64.
38. VEGFA activates erythropoietin receptor and enhances VEGFR2-mediated pathological angiogenesis. Yang Z, etal., Am J Pathol. 2014 Apr;184(4):1230-9. doi: 10.1016/j.ajpath.2013.12.023. Epub 2014 Mar 12.
39. Erythropoietin attenuates oxidative stress and apoptosis in Schwann cells isolated from streptozotocin-induced diabetic rats. Yu T, etal., J Pharm Pharmacol. 2014 Aug;66(8):1150-60. doi: 10.1111/jphp.12244. Epub 2014 Mar 27.
40. [Expression of erythropoietin and its receptor in the brain of newborn rats suffering from fetal distress]. Zhang ZM, etal., Zhongguo Dang Dai Er Ke Za Zhi. 2011 Nov;13(11):912-6.
Additional References at PubMed
PMID:1312671   PMID:1318465   PMID:1431103   PMID:1537850   PMID:1656233   PMID:1662116   PMID:1849897   PMID:1962754   PMID:2162479   PMID:2175360   PMID:2175917   PMID:2539263  
PMID:2550142   PMID:7505116   PMID:7545788   PMID:7553874   PMID:7558020   PMID:7558021   PMID:7559635   PMID:7685197   PMID:7731971   PMID:7889566   PMID:7926723   PMID:7926812  
PMID:7958443   PMID:8016154   PMID:8068943   PMID:8118044   PMID:8119943   PMID:8142650   PMID:8179929   PMID:8188294   PMID:8196600   PMID:8268657   PMID:8288218   PMID:8341708  
PMID:8343951   PMID:8361212   PMID:8382775   PMID:8439730   PMID:8440347   PMID:8499630   PMID:8521813   PMID:8562964   PMID:8566749   PMID:8617735   PMID:8620534   PMID:8639815  
PMID:8657137   PMID:8662221   PMID:8665851   PMID:8729004   PMID:8799165   PMID:8906421   PMID:8977232   PMID:9002945   PMID:9324354   PMID:9328451   PMID:9344654   PMID:9573010  
PMID:9590173   PMID:9611252   PMID:9639506   PMID:9811459   PMID:10349636   PMID:10409505   PMID:10430179   PMID:10477673   PMID:10557295   PMID:10610728   PMID:11042159   PMID:11076861  
PMID:11217851   PMID:11290583   PMID:11406592   PMID:11435319   PMID:11443118   PMID:11520789   PMID:11713346   PMID:11739165   PMID:11779507   PMID:11807041   PMID:11895800   PMID:11911958  
PMID:11997394   PMID:12239135   PMID:12381781   PMID:12441334   PMID:12444928   PMID:12466851   PMID:12477932   PMID:12486028   PMID:12606578   PMID:12795333   PMID:12859190   PMID:12869513  
PMID:12893747   PMID:12909618   PMID:12917333   PMID:12930840   PMID:14527337   PMID:14602718   PMID:14636581   PMID:14662339   PMID:14770308   PMID:15007095   PMID:15008895   PMID:15090451  
PMID:15102474   PMID:15456912   PMID:15489334   PMID:15531367   PMID:15618518   PMID:15657048   PMID:15705783   PMID:15741742   PMID:15953601   PMID:16084495   PMID:16141072   PMID:16141073  
PMID:16151855   PMID:16174761   PMID:16249375   PMID:16287714   PMID:16292344   PMID:16332976   PMID:16380376   PMID:16414957   PMID:16436614   PMID:16511603   PMID:16524748   PMID:16534010  
PMID:16581793   PMID:16627753   PMID:16652367   PMID:16775250   PMID:16781691   PMID:16787915   PMID:16940183   PMID:16945928   PMID:16980619   PMID:17024180   PMID:17105817   PMID:17141159  
PMID:17173930   PMID:17293480   PMID:17300687   PMID:17403918   PMID:17404160   PMID:17420256   PMID:17431131   PMID:17476283   PMID:17493690   PMID:17548578   PMID:17584830   PMID:17604282  
PMID:17699753   PMID:17981124   PMID:18158285   PMID:18239084   PMID:18258751   PMID:18278456   PMID:18287559   PMID:18349318   PMID:18424770   PMID:18485751   PMID:18495327   PMID:18627790  
PMID:18657521   PMID:18800919   PMID:18854306   PMID:18855427   PMID:19218878   PMID:19537929   PMID:19584401   PMID:19836979   PMID:19941827   PMID:20028972   PMID:20299672   PMID:20395592  
PMID:20457756   PMID:20488988   PMID:20554972   PMID:20649603   PMID:20711497   PMID:20806411   PMID:20810925   PMID:21029371   PMID:21149549   PMID:21183685   PMID:21255641   PMID:21256055  
PMID:21267068   PMID:21304510   PMID:21324364   PMID:21360263   PMID:21362419   PMID:21421837   PMID:21527022   PMID:21610079   PMID:21677750   PMID:21833990   PMID:21873635   PMID:21894148  
PMID:21998251   PMID:22044999   PMID:22086418   PMID:22260730   PMID:22371173   PMID:22422820   PMID:22508938   PMID:22566683   PMID:22627765   PMID:22669473   PMID:22669948   PMID:22808010  
PMID:22844537   PMID:22969412   PMID:23134786   PMID:23313788   PMID:23361909   PMID:23428869   PMID:23576758   PMID:23636173   PMID:23795291   PMID:23840778   PMID:23885016   PMID:23990359  
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PMID:25289670   PMID:25356849   PMID:25411424   PMID:25418301   PMID:25519735   PMID:25560321   PMID:25715089   PMID:25765155   PMID:25790231   PMID:25870109   PMID:25952549   PMID:26228485  
PMID:26316120   PMID:26481148   PMID:26534925   PMID:26563310   PMID:26872696   PMID:27141965   PMID:27264182   PMID:27297878   PMID:27373493   PMID:27397585   PMID:27456828   PMID:27482003  
PMID:27657745   PMID:27998978   PMID:28038963   PMID:28095473   PMID:28169986   PMID:28283542   PMID:28338096   PMID:28504707   PMID:28724789   PMID:29078273   PMID:29186677   PMID:29187371  
PMID:29282252   PMID:29391474   PMID:29576450   PMID:29599243   PMID:29934585   PMID:30185409   PMID:30213870   PMID:30292638   PMID:30314756   PMID:30630985   PMID:30674470   PMID:31013255  
PMID:31151988   PMID:31278195   PMID:31434755   PMID:31444954   PMID:31554636   PMID:31813828   PMID:31887343   PMID:32093902   PMID:32152318   PMID:32178723   PMID:32350523   PMID:32434995  
PMID:32629063   PMID:32634119   PMID:32671900   PMID:32785675   PMID:32907997   PMID:32950599   PMID:33205838   PMID:33334894   PMID:33370780   PMID:33495244   PMID:33512417   PMID:33571427  
PMID:33579907   PMID:33753942   PMID:33863882   PMID:34098576   PMID:34138843   PMID:34142210   PMID:34180713   PMID:34234691   PMID:34261755   PMID:34433021   PMID:34663679   PMID:34669439  
PMID:34707288   PMID:34921133   PMID:34925338   PMID:35274823   PMID:35361248   PMID:35389892   PMID:35884958   PMID:36130519   PMID:36233351   PMID:36307435   PMID:36414671   PMID:36593241  
PMID:36649586   PMID:37127673   PMID:37813816   PMID:37945644   PMID:38127913   PMID:38395995   PMID:38509204   PMID:39284834   PMID:39541460   PMID:40238885   PMID:40260585  


Genomics

Comparative Map Data
Epor
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39921,870,193 - 21,874,915 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl921,870,193 - 21,874,802 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38921,958,897 - 21,963,576 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl921,958,897 - 21,963,506 (-)Ensemblmm10GRCm38
MGSCv37921,763,343 - 21,768,020 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36921,709,306 - 21,713,878 (-)NCBIMGSCv36mm8
Celera919,228,327 - 19,233,004 (-)NCBICelera
Cytogenetic Map9A3NCBI
cM Map97.93NCBI
EPOR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381911,377,207 - 11,384,314 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1911,377,207 - 11,384,342 (-)Ensemblhg38GRCh38
GRCh371911,487,883 - 11,494,990 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361911,349,475 - 11,356,019 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341911,349,474 - 11,356,019NCBI
Celera1911,382,748 - 11,389,885 (-)NCBICelera
Cytogenetic Map19p13.2NCBI
HuRef1911,063,851 - 11,070,988 (-)NCBIHuRef
CHM1_11911,488,891 - 11,496,028 (-)NCBICHM1_1
T2T-CHM13v2.01911,504,177 - 11,511,284 (-)NCBIT2T-CHM13v2.0
Epor
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8828,765,738 - 28,770,371 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl828,765,746 - 28,770,322 (-)EnsemblGRCr8
mRatBN7.2820,489,678 - 20,494,257 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl820,489,678 - 20,494,257 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx824,519,099 - 24,523,676 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0822,816,236 - 22,820,813 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0820,719,272 - 20,723,848 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0822,969,737 - 22,974,468 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl822,969,745 - 22,974,321 (-)Ensemblrn6Rnor6.0
Rnor_5.0823,024,521 - 23,029,191 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4821,061,310 - 21,065,886 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera821,880,243 - 21,884,819 (-)NCBICelera
RGSC_v3.1821,061,309 - 21,065,886 (-)NCBI
Cytogenetic Map8q13NCBI
Epor
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554952,293,540 - 2,298,715 (-)Ensembl
ChiLan1.0NW_0049554952,293,587 - 2,299,302 (-)NCBIChiLan1.0ChiLan1.0
EPOR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22016,291,699 - 16,298,323 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11915,290,664 - 15,297,285 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01910,925,148 - 10,931,955 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11911,635,248 - 11,642,383 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1911,635,248 - 11,642,383 (-)EnsemblpanPan2panpan1.1
EPOR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12049,945,777 - 49,950,856 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2049,945,777 - 49,950,856 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2049,816,892 - 49,821,971 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02050,463,402 - 50,469,165 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2050,464,086 - 50,469,165 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12049,674,383 - 49,679,467 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02050,100,740 - 50,105,821 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02050,343,701 - 50,348,780 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Epor
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118208,880,801 - 208,886,331 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366591,468,634 - 1,473,880 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366591,468,391 - 1,473,880 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EPOR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl270,063,519 - 70,068,821 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1270,063,601 - 70,068,821 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2270,426,996 - 70,432,219 (-)NCBISscrofa10.2Sscrofa10.2susScr3
EPOR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1610,313,382 - 10,320,196 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl610,313,775 - 10,320,066 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660749,573,409 - 9,580,946 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Epor
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248283,181,957 - 3,187,231 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248283,181,772 - 3,187,242 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Epor
185 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:138
Count of miRNA genes:115
Interacting mature miRNAs:133
Transcripts:ENSMUST00000006397
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
35673312Ari7_mantibody response to influenza 7, day 45, IgG3 (mouse)9780000122211296Mouse
13504834Hdlq109_mHDL QTL 109 (mouse)91670964150709641Mouse
1357465Vtbt6_mvertebral trabecular bone trait 6 (mouse)Not determined91697884050978943Mouse
13504833Bglu19_mblood glucose level 19 (mouse)9991076843910768Mouse
1357637Si5lq2_mserum IGFBP-5 level QTL 2 (mouse)Not determined91541175149411890Mouse
12790993Adq1_maortic diameter QTL 1 (mouse)91574962749749627Mouse
10043917Obq37_mobesity QTL 37 (mouse)Not determined91339117547391175Mouse
12790997Adq2_maortic diameter QTL 2 (mouse)91574962749749627Mouse
12880415V125Dq7_mvitamin D active form serum level QTL 7 (mouse)91601129650011296Mouse
1300849Sles4_msystemic lupus erythmatosus suppressor 4 (mouse)Not determined9910756237306370Mouse
12880416V125Dq8_mvitamin D active form serum level QTL 8 (mouse)91601129650011296Mouse
13434920Dcollq1_mdifferential colonization level QTL 1 (mouse)9130341840Mouse
1301045Sluc10_msusceptibility to lung cancer 10 (mouse)Not determined92030619754306370Mouse
1300532Tbs2_mtuberculosis severity 2 (mouse)Not determined91236997046370114Mouse
4141591Cq4_mcholesterol QTL 4 (mouse)Not determined91541175149411890Mouse
1301883Skull12_mskull morphology 12 (mouse)Not determined92030619754306370Mouse
11354951Pdcc3_mplasmacytoid dentritic cell compartment 3 (mouse)91574962749749627Mouse
1301439Morph2_mmorphine antinociception 2 (mouse)Not determined92015336254153492Mouse
4142352Lmr17_mleishmaniasis resistance 17 (mouse)Not determined92030619754306370Mouse
12904939Edlmmq8_mextensor digitorum longus muscle mass QTL 8 (mouse)92085274054852740Mouse
1300899Chol6_mcholesterol 6 (mouse)Not determined9129902913Mouse
1300643Pvcan2_mprotection against vaginal candidiasis 2 (mouse)Not determined91994340653943525Mouse
10043950Pbft5_mpercent body fat 5 (mouse)Not determined92030619754306370Mouse
4141447Cfmq2_mcystic fibrosis modifier QTL 2 (mouse)Not determined91541175149411890Mouse
1301421Lgth4_mbody length 4 (mouse)Not determined91541175149411890Mouse

Markers in Region
Epor  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38921,961,709 - 21,962,241UniSTSGRCm38
MGSCv37921,766,153 - 21,766,685UniSTSGRCm37
Celera919,231,137 - 19,231,669UniSTS
Cytogenetic Map9A3UniSTS
cM Map95.0UniSTS
cM Map95.0UniSTS
cM Map95.0UniSTS
D9Mit86  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38921,963,969 - 21,964,096UniSTSGRCm38
MGSCv37921,768,413 - 21,768,540UniSTSGRCm37
Celera919,233,397 - 19,233,524UniSTS
Cytogenetic Map9A3UniSTS
cM Map95.0UniSTS
Whitehead Genetic94.4UniSTS
PMC14696P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38921,963,426 - 21,963,864UniSTSGRCm38
MGSCv37921,767,870 - 21,768,308UniSTSGRCm37
Celera919,232,854 - 19,233,292UniSTS
Cytogenetic Map9A3UniSTS
cM Map95.0UniSTS
PMC150206P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38921,959,047 - 21,959,802UniSTSGRCm38
MGSCv37921,763,491 - 21,764,246UniSTSGRCm37
Celera919,228,475 - 19,229,230UniSTS
Cytogenetic Map9A3UniSTS
cM Map95.0UniSTS
PMC150350P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38921,959,193 - 21,959,789UniSTSGRCm38
MGSCv37921,763,637 - 21,764,233UniSTSGRCm37
Celera919,228,621 - 19,229,217UniSTS
Cytogenetic Map9A3UniSTS
cM Map95.0UniSTS
Epor  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9A3UniSTS
Epor  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9A3UniSTS
Epor  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38921,959,040 - 21,959,491UniSTSGRCm38
MGSCv37921,763,484 - 21,763,935UniSTSGRCm37
Celera919,228,468 - 19,228,919UniSTS
Cytogenetic Map9A3UniSTS
cM Map95.0UniSTS
Epor  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38921,960,802 - 21,961,850UniSTSGRCm38
MGSCv37921,765,246 - 21,766,294UniSTSGRCm37
Celera919,230,230 - 19,231,278UniSTS
Cytogenetic Map9A3UniSTS
cM Map95.0UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001411820 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001411821 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_010149 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_177941 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001778795 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004935316 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC163623 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK010968 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK139031 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB842890 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC003953 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC046282 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466522 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J04843 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M38133 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M62360 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M91459 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X53081 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000006397   ⟹   ENSMUSP00000006397
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl921,870,193 - 21,874,802 (-)Ensembl
GRCm38.p6 Ensembl921,958,897 - 21,963,506 (-)Ensembl
Ensembl Acc Id: ENSMUST00000213181   ⟹   ENSMUSP00000149402
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl921,872,780 - 21,873,860 (-)Ensembl
GRCm38.p6 Ensembl921,961,484 - 21,962,564 (-)Ensembl
RefSeq Acc Id: NM_001411820   ⟹   NP_001398749
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39921,870,199 - 21,873,688 (-)NCBI
RefSeq Acc Id: NM_001411821   ⟹   NP_001398750
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39921,870,199 - 21,873,688 (-)NCBI
RefSeq Acc Id: NM_010149   ⟹   NP_034279
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39921,870,199 - 21,874,872 (-)NCBI
GRCm38921,958,899 - 21,963,576 (-)NCBI
MGSCv37921,763,343 - 21,768,020 (-)RGD
Celera919,228,327 - 19,233,004 (-)RGD
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_177941
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39921,870,199 - 21,874,872 (-)NCBI
RefSeq Acc Id: XR_001778795
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39921,871,057 - 21,874,595 (-)NCBI
GRCm38921,959,761 - 21,963,299 (-)NCBI
Sequence:
RefSeq Acc Id: XR_004935316
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39921,870,193 - 21,874,915 (-)NCBI
Sequence:
RefSeq Acc Id: NP_034279   ⟸   NM_010149
- Peptide Label: isoform 1 precursor
- UniProtKB: Q63852 (UniProtKB/Swiss-Prot),   P14753 (UniProtKB/Swiss-Prot),   Q3UTV9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000006397   ⟸   ENSMUST00000006397
Ensembl Acc Id: ENSMUSP00000149402   ⟸   ENSMUST00000213181
RefSeq Acc Id: NP_001398750   ⟸   NM_001411821
- Peptide Label: isoform 3
RefSeq Acc Id: NP_001398749   ⟸   NM_001411820
- Peptide Label: isoform 2
Protein Domains
Fibronectin type-III   Growth hormone/erythropoietin receptor ligand

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P14753-F1-model_v2 AlphaFold P14753 1-507 view protein structure

Promoters
RGD ID:6848406
Promoter ID:MM_ACW:49834
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Kidney,   Lung
Transcripts:EPOR.DSEP07-UNSPLICED
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36921,764,046 - 21,765,172 (-)MPROMDB
RGD ID:6848409
Promoter ID:MM_ACW:49835
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney,   Spleen
Transcripts:EPOR.ASEP07,   EPOR.CSEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36921,766,889 - 21,767,389 (-)MPROMDB
RGD ID:8668994
Promoter ID:EPDNEW_M12528
Type:multiple initiation site
Name:Epor_1
Description:Mus musculus erythropoietin receptor , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38921,963,576 - 21,963,636EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:95408 AgrOrtholog
Ensembl Genes ENSMUSG00000006235 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000006397 ENTREZGENE
  ENSMUST00000006397.7 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot
InterPro Erythropoietin_rcpt UniProtKB/Swiss-Prot
  FN3_dom UniProtKB/Swiss-Prot
  FN3_sf UniProtKB/Swiss-Prot
  Growth/epo_recpt_lig-bind UniProtKB/Swiss-Prot
  Ig-like_fold UniProtKB/Swiss-Prot
  Long_hematopoietin_rcpt_CS UniProtKB/Swiss-Prot
KEGG Report mmu:13857 UniProtKB/Swiss-Prot
MGD MGI:95408 ENTREZGENE
NCBI Gene 13857 ENTREZGENE
PANTHER CYTOKINE RECEPTOR UniProtKB/Swiss-Prot
  PTHR23037:SF28 UniProtKB/Swiss-Prot
Pfam EpoR_lig-bind UniProtKB/Swiss-Prot
  fn3 UniProtKB/Swiss-Prot
PhenoGen Epor PhenoGen
PIRSF EPO_receptor UniProtKB/Swiss-Prot
PROSITE FN3 UniProtKB/Swiss-Prot
  HEMATOPO_REC_L_F1 UniProtKB/Swiss-Prot
SMART FN3 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF49265 UniProtKB/Swiss-Prot
UniProt A0A1L1SRC0_MOUSE UniProtKB/TrEMBL
  EPOR_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3UTV9 ENTREZGENE, UniProtKB/TrEMBL
  Q63852 ENTREZGENE
UniProt Secondary Q63852 UniProtKB/Swiss-Prot