Ednrb (endothelin receptor type B) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Pathways
Gene: Ednrb (endothelin receptor type B) Mus musculus
Analyze
Symbol: Ednrb
Name: endothelin receptor type B
RGD ID: 10505
MGI Page MGI
Description: Enables endothelin receptor activity. Involved in several processes, including digestive tract development; metal ion transport; and protein transport. Acts upstream of or within several processes, including melanocyte differentiation; neuroblast migration; and posterior midgut development. Predicted to be located in nuclear membrane and plasma membrane. Is expressed in several structures, including central nervous system; genitourinary system; gut; heart; and peripheral nervous system. Used to study Hirschsprung's disease and Waardenburg syndrome type 4A. Human ortholog(s) of this gene implicated in ABCD syndrome; Hirschsprung's disease; Waardenburg syndrome (multiple); asthma; and pulmonary hypertension. Orthologous to human EDNRB (endothelin receptor type B).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: AU022549; endothelin B receptor; endothelin receptor non-selective type; ET-B; ET-BR; ET>B<; ETb; ETR-; ETR-b; piebald; s; Sox10; Sox10m1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3914104,052,051 - 104,083,248 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl14104,052,061 - 104,081,838 (-)EnsemblGRCm39 Ensembl
GRCm3814103,814,615 - 103,844,508 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl14103,814,625 - 103,844,402 (-)EnsemblGRCm38mm10GRCm38
MGSCv3714104,213,842 - 104,243,390 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3614102,700,305 - 102,729,375 (-)NCBIMGSCv36mm8
Celera14102,434,540 - 102,464,042 (-)NCBICelera
Cytogenetic Map14E2.3NCBI
cM Map1453.05NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(R)-noradrenaline  (ISO)
(S)-colchicine  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine  (ISO)
2-butoxyethanol  (EXP)
2-hydroxypropanoic acid  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO)
3,4-methylenedioxymethamphetamine  (EXP,ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (EXP)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (ISO)
6alpha-methylprednisolone  (ISO)
7,12-dimethyltetraphene  (ISO)
7-NITROINDAZOLE  (ISO)
8-bromo-3',5'-cyclic GMP  (ISO)
acadesine  (ISO)
acetamide  (ISO)
acetylsalicylic acid  (ISO)
acrylamide  (ISO)
actinomycin D  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (ISO)
ammonium chloride  (ISO)
amphotericin B  (ISO)
angiotensin II  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
arsane  (EXP)
arsenic atom  (EXP)
arsenous acid  (ISO)
atrasentan  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (EXP)
bexarotene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bosentan  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (EXP)
carbon nanotube  (EXP)
celecoxib  (ISO)
CGP 52608  (ISO)
chlorambucil  (EXP)
chloroprene  (ISO)
chlorpyrifos  (ISO)
choline  (EXP)
chromium atom  (EXP)
chrysene  (EXP)
cisplatin  (ISO)
cocaine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
Cuprizon  (ISO)
cycloheximide  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
daunorubicin  (ISO)
Deoxycorticosterone acetate  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (EXP)
dibutyl phthalate  (EXP)
dimethyl sulfoxide  (ISO)
dioxygen  (EXP,ISO)
dorsomorphin  (ISO)
endosulfan  (ISO)
enrasentan  (ISO)
entinostat  (ISO)
ethanol  (EXP,ISO)
etoposide  (EXP)
fenoterol  (ISO)
folic acid  (EXP)
fulvestrant  (ISO)
gefitinib  (EXP)
genistein  (EXP)
gentamycin  (ISO)
hydrogen cyanide  (EXP)
Ile(5)-angiotensin II  (ISO)
indometacin  (ISO)
inulin  (EXP)
isoprenaline  (ISO)
isoquinoline-1,5-diol  (ISO)
ketoconazole  (ISO)
L-ascorbic acid  (EXP)
L-methionine  (EXP)
lead diacetate  (ISO)
malathion  (ISO)
mercury dibromide  (ISO)
methotrexate  (EXP)
methylmercury chloride  (ISO)
methylseleninic acid  (ISO)
mifepristone  (ISO)
MK-2206  (ISO)
N(gamma)-nitro-L-arginine methyl ester  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide  (ISO)
N-ethyl-N-nitrosourea  (EXP)
N-methyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (ISO)
nicotine  (ISO)
nicotinic acid  (EXP)
nimesulide  (ISO)
nitric oxide  (ISO)
nitrites  (ISO)
nitrofen  (ISO)
nitroprusside  (ISO)
Nonylphenol  (ISO)
ozone  (EXP,ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paricalcitol  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
permethrin  (ISO)
phenobarbital  (EXP)
phenylephrine  (ISO)
phenylmercury acetate  (ISO)
phosphoramidon  (ISO)
phosphorus atom  (ISO)
phosphorus(.)  (ISO)
picrotoxin  (ISO)
potassium chloride  (ISO)
potassium chromate  (ISO)
potassium cyanide  (EXP)
progesterone  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rofecoxib  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
SB-239063  (ISO)
serpentine asbestos  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sorafenib  (ISO)
staurosporine  (ISO)
sulfadimethoxine  (ISO)
Tanshinone I  (ISO)
telmisartan  (ISO)
testosterone  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (EXP)
thimerosal  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
trichloroethene  (ISO)
trichostatin A  (ISO)
troglitazone  (EXP)
U-73122  (ISO)
udenafil  (ISO)
urethane  (EXP)
valproic acid  (ISO)
venlafaxine hydrochloride  (ISO)
vincaleukoblastine  (ISO)
vincristine  (ISO)
vorinostat  (ISO)
wedelolactone  (ISO)
zinc atom  (ISO)
zinc sulfate  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aldosterone metabolic process  (IMP)
calcium ion transmembrane transport  (IDA,IGI,IMP)
calcium-mediated signaling  (ISO)
canonical Wnt signaling pathway  (IGI)
cellular response to lipopolysaccharide  (ISO)
cGMP-mediated signaling  (ISO)
chordate pharynx development  (IDA,IMP)
developmental pigmentation  (IBA,IMP)
endothelin receptor signaling pathway  (IBA,IGI,IMP,ISO)
enteric nervous system development  (IDA)
enteric smooth muscle cell differentiation  (IDA)
epithelial fluid transport  (ISO)
establishment of endothelial barrier  (IDA)
G protein-coupled receptor signaling pathway  (IDA,IGI)
gene expression  (IGI,IMP)
heparin metabolic process  (IGI)
macrophage chemotaxis  (ISO)
melanocyte differentiation  (IDA,IMP,ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of neuron maturation  (IDA)
negative regulation of protein metabolic process  (ISO)
negative regulation of transcription by RNA polymerase II  (IDA,ISO)
neural crest cell migration  (IMP)
neuroblast migration  (IMP)
peripheral nervous system development  (IMP)
phospholipase C-activating G protein-coupled receptor signaling pathway  (ISO)
pigmentation  (IMP,ISO)
podocyte differentiation  (IGI)
positive regulation of canonical NF-kappaB signal transduction  (IMP)
positive regulation of cell population proliferation  (ISO)
positive regulation of cytosolic calcium ion concentration  (ISO)
positive regulation of penile erection  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of urine volume  (ISO)
posterior midgut development  (IMP)
protein transmembrane transport  (IDA)
regulation of blood pressure  (IGI,IMP,ISO)
regulation of epithelial cell proliferation  (ISO)
regulation of fever generation  (ISO)
regulation of heart rate  (IGI,IMP)
regulation of pH  (IMP)
renal albumin absorption  (IGI)
renal sodium excretion  (IMP)
renal sodium ion absorption  (IMP)
renin secretion into blood stream  (IMP)
response to endothelin  (ISO)
response to lipopolysaccharide  (ISO)
response to organic cyclic compound  (ISO)
response to organic substance  (IGI)
response to pain  (ISO)
response to sodium phosphate  (IMP)
signal transduction  (IEA)
sodium ion homeostasis  (IGI)
vasoconstriction  (IBA,ISO)
vasodilation  (ISO)
vein smooth muscle contraction  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal artery morphology  (IAGP)
abnormal blood gas level  (IAGP)
abnormal blood homeostasis  (IAGP)
abnormal blood pH regulation  (IAGP)
abnormal bone ossification  (IAGP)
abnormal brain morphology  (IAGP)
abnormal cartilage morphology  (IEA)
abnormal cell migration  (IAGP)
abnormal choroid pigmentation  (IAGP)
abnormal coat/hair pigmentation  (IAGP)
abnormal cochlea morphology  (IAGP)
abnormal cochlear hair cell morphology  (IAGP)
abnormal cochlear sensory epithelium morphology  (IAGP)
abnormal colon goblet cell morphology  (IAGP)
abnormal colon morphology  (IAGP)
abnormal Deiters cell morphology  (IAGP)
abnormal diaphragm morphology  (IAGP)
abnormal direction of heart looping  (IAGP)
abnormal enteric nervous system morphology  (IAGP)
abnormal enteric neural crest cell migration  (IAGP)
abnormal enteric neuron morphology  (IAGP)
abnormal epidermal melanocyte morphology  (IAGP)
abnormal eye pigmentation  (IAGP)
abnormal feces composition  (IAGP)
abnormal foot pigmentation  (IEA)
abnormal hair follicle melanocyte morphology  (IAGP)
abnormal head morphology  (IAGP)
abnormal hearing physiology  (IAGP)
abnormal hindgut morphology  (IAGP)
abnormal inner ear morphology  (IAGP)
abnormal intestinal mucosa morphology  (IAGP)
abnormal intestine physiology  (IAGP)
abnormal large intestine crypts of Lieberkuhn morphology  (IAGP)
abnormal mature B cell number  (IAGP)
abnormal melanocyte proliferation  (IAGP)
abnormal nervous system morphology  (IAGP)
abnormal neuromuscular synapse morphology  (IAGP)
abnormal nitric oxide homeostasis  (IAGP)
abnormal oxygen level  (IAGP)
abnormal palatal rugae morphology  (IAGP)
abnormal palate bone morphology  (IAGP)
abnormal Peyer's patch morphology  (IAGP)
abnormal pharyngeal arch morphology  (IAGP)
abnormal phrenic nerve morphology  (IAGP)
abnormal pigmentation pattern  (IAGP)
abnormal retina vasculature morphology  (IAGP)
abnormal secondary palate development  (IAGP)
abnormal skeleton morphology  (IEA)
abnormal soft palate morphology  (IAGP)
abnormal spleen morphology  (IAGP)
abnormal splenic cell ratio  (IAGP)
abnormal stria vascularis morphology  (IAGP)
abnormal tail pigmentation  (IEA)
abnormal urine homeostasis  (IAGP)
abnormal urine sodium level  (IAGP)
abnormal vitelline vasculature morphology  (IAGP)
absent coat pigmentation  (IAGP)
absent enteric neurons  (IAGP)
absent hair follicle melanin granules  (IAGP)
absent palatine bone horizontal plate  (IAGP)
absent strial intermediate cells  (IAGP)
aganglionic megacolon  (IAGP)
belly spot  (IEA)
cachexia  (IAGP)
cleft secondary palate  (IAGP)
cleft upper lip  (IAGP)
cochlear hair cell degeneration  (IAGP)
deafness  (IAGP)
decreased acute inflammation  (IAGP)
decreased B cell number  (IAGP)
decreased body size  (IAGP)
decreased circulating lactate level  (IAGP)
decreased germinal center B cell number  (IAGP)
decreased IgA level  (IAGP)
decreased marginal zone B cell number  (IAGP)
decreased melanocyte number  (IAGP)
decreased renin activity  (IAGP)
decreased response of heart to induced stress  (IAGP)
decreased spleen red pulp amount  (IAGP)
decreased spleen weight  (IAGP)
decreased spleen white pulp amount  (IAGP)
decreased tumor-free survival time  (IAGP)
decreased vasodilation  (IAGP)
distended abdomen  (IAGP)
embryonic lethality between implantation and somite formation, complete penetrance  (IAGP)
embryonic lethality, complete penetrance  (IAGP)
enlarged pericardium  (IAGP)
failure of palatal shelf elevation  (IAGP)
head spot  (IEA)
hemopericardium  (IAGP)
hypercapnia  (IAGP)
hypoalgesia  (IAGP)
hypocapnia  (IAGP)
hypoxia  (IAGP)
incomplete embryo turning  (IAGP)
increased cardiac muscle contractility  (IAGP)
increased cardiac output  (IAGP)
increased cell proliferation  (IAGP)
increased mean systemic arterial blood pressure  (IAGP)
increased melanoma incidence  (IAGP)
increased metastatic potential  (IAGP)
increased mitotic index  (IAGP)
increased systemic arterial blood pressure  (IAGP)
increased systemic arterial diastolic blood pressure  (IAGP)
increased systemic arterial systolic blood pressure  (IAGP)
intestinal obstruction  (IAGP)
large intestinal inflammation  (IAGP)
lethality at weaning  (IEA)
lethality at weaning, complete penetrance  (IAGP)
lethality throughout fetal growth and development, complete penetrance  (IAGP)
maxillary shelf hypoplasia  (IAGP)
megacolon  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
oliguria  (IAGP)
organ of Corti degeneration  (IAGP)
pericardial effusion  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
premature death  (IAGP)
prenatal lethality  (IAGP)
prenatal lethality, complete penetrance  (IAGP)
preweaning lethality, complete penetrance  (IAGP)
preweaning lethality, incomplete penetrance  (IAGP)
reduced hair shaft melanin granule number  (IAGP)
respiratory distress  (IAGP)
slow postnatal weight gain  (IAGP)
small Peyer's patches  (IAGP)
small spleen  (IAGP)
thin stria vascularis  (IAGP)
variable body spotting  (IAGP)
variable depigmentation  (IAGP)
white spotting  (IAGP)
yellow coat color  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Mutation of the endothelin-receptor B gene in Waardenburg-Hirschsprung disease. Attie T, etal., Hum Mol Genet. 1995 Dec;4(12):2407-9.
2. Endothelin-1 receptor subtypes expression and binding in a perfused rat model of myocardial infarction. Bikhazi AB, etal., Comp Biochem Physiol C Toxicol Pharmacol. 2003 Jan;134(1):35-43.
3. Interstitial deletion of the endothelin-B receptor gene in the spotting lethal (sl) rat. Ceccherini I, etal., Hum Mol Genet 1995 Nov;4(11):2089-96.
4. Increased ET-1 and reduced ET(B) receptor expression in uremic hypertensive rats. D'Amours M, etal., Clin Exp Hypertens. 2010 Jan;32(1):61-9.
5. Lymphopenia in Ednrb-deficient rat was strongly modified by genetic background. Dang R, etal., Biomed Res. 2012;33(4):249-53.
6. QTL analysis identifies a modifier locus of aganglionosis in the rat model of Hirschsprung disease carrying Ednrb(sl) mutations. Dang R, etal., PLoS One. 2011;6(11):e27902. Epub 2011 Nov 22.
7. Genetic background strongly modifies the severity of symptoms of Hirschsprung disease, but not hearing loss in rats carrying Ednrb(sl) mutations. Dang R, etal., PLoS One. 2011;6(9):e24086. Epub 2011 Sep 7.
8. Endotoxin causes pulmonary hypertension by upregulating smooth muscle endothelin type-B receptors: role of aldose reductase. Dschietzig T, etal., Shock. 2008 Aug;30(2):189-96.
9. Transgenic expression of the endothelin-B receptor prevents congenital intestinal aganglionosis in a rat model of Hirschsprung disease. Gariepy CE, etal., J Clin Invest 1998 Sep 15;102(6):1092-101.
10. Salt-sensitive hypertension in endothelin-B receptor-deficient rats. Gariepy CE, etal., J Clin Invest 2000 Apr;105(7):925-33.
11. Null mutation of endothelin receptor type B gene in spotting lethal rats causes aganglionic megacolon and white coat color. Gariepy CE, etal., Proc Natl Acad Sci U S A 1996 Jan 23;93(2):867-72.
12. Polymorphisms in genes of the endothelin system and cerebral small-vessel disease. Gormley K, etal., Stroke. 2005 Aug;36(8):1656-60. Epub 2005 Jul 7.
13. Up-regulation of endothelin receptor function and mRNA expression in airway smooth muscle cells following Sephadex-induced airway inflammation. Granstrom BW, etal., Basic Clin Pharmacol Toxicol. 2004 Jul;95(1):43-8.
14. QTL analysis of modifiers for pigmentary disorder in rats carrying Ednrb(sl) mutations. Huang J, etal., Sci Rep. 2016 Jan 22;6:19697. doi: 10.1038/srep19697.
15. Increased immunoreactivity of endothelin-1 and endothelin B receptor in human atherosclerotic lesions. A possible role in atherogenesis. Iwasa S, etal., Atherosclerosis. 1999 Sep;146(1):93-100.
16. Endothelin 1 and 3 enhance neuronal nitric oxide synthase activity through ETB receptors involving multiple signaling pathways in the rat anterior hypothalamus. Jaureguiberry MS, etal., Peptides. 2004 Jul;25(7):1133-8.
17. The role of ET(A) and ET(B) receptor antagonists in acute and allergic inflammation in mice. Kassuya CA, etal., Peptides. 2008 Aug;29(8):1329-37. Epub 2008 Mar 16.
18. Effect of pyrrolidine dithiocarbamate on hepatic vascular stress gene expression during ischemia and reperfusion. Lee CH, etal., Eur J Pharmacol. 2008 Oct 24;595(1-3):100-7. Epub 2008 Aug 9.
19. Involvement of NO and MEK/ERK pathway in enhancement of endothelin-1-induced mesenteric artery contraction in later-stage type 2 diabetic Goto-Kakizaki rat. Matsumoto T, etal., Am J Physiol Heart Circ Physiol. 2009 May;296(5):H1388-97. Epub 2009 Mar 13.
20. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
21. MGDs mouse GO annotations MGD data from the GO Consortium
22. MGD IEA MGD IEA
23. Inhibitory effects of PPAR-gamma on endothelin-1-induced inflammatory pathways in vascular smooth muscle cells from normotensive and hypertensive rats. Montezano AC, etal., J Am Soc Hypertens. 2007 Mar-Apr;1(2):150-60.
24. Polymorphisms of the endothelin-A and -B receptor genes in relation to blood pressure and myocardial infarction: the Etude Cas-Temoins sur l'Infarctus du Myocarde (ECTIM) Study. Nicaud V, etal., Am J Hypertens. 1999 Mar;12(3):304-10.
25. Roles of endothelin ETA and ETB receptors in the pathogenesis of monocrotaline-induced pulmonary hypertension. Nishida M, etal., J Cardiovasc Pharmacol. 2004 Aug;44(2):187-91.
26. Endothelin-1 (ET-1) is increased in rat retina after crushing optic nerve. Oku H, etal., Curr Eye Res. 2008 Jul;33(7):611-20.
27. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
28. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
29. A missense mutation of the endothelin-B receptor gene in multigenic Hirschsprung's disease. Puffenberger EG, etal., Cell. 1994 Dec 30;79(7):1257-66.
30. Mouse MP Annotation Import Pipeline RGD automated import pipeline
31. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
32. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
33. ETB receptor polymorphism is associated with airway obstruction. Taille C, etal., BMC Pulm Med. 2007 Apr 30;7:5.
34. BMPR2 mutation alters the lung macrophage endothelin-1 cascade in a mouse model and patients with heritable pulmonary artery hypertension. Talati M, etal., Am J Physiol Lung Cell Mol Physiol. 2010 Sep;299(3):L363-73. Epub 2010 Jun 18.
35. Effects of exogenous big endothelin-1 on postischemic cardiac dysfunction and norepinephrine overflow in rat hearts. Tawa M, etal., Hypertens Res. 2011 Feb;34(2):218-24. Epub 2010 Nov 4.
36. ABCD syndrome is caused by a homozygous mutation in the EDNRB gene. Verheij JB, etal., Am J Med Genet. 2002 Mar 15;108(3):223-5.
37. Ischemic heart disease induces upregulation of endothelin receptor mRNA in human coronary arteries. Wackenfors A, etal., Eur J Pharmacol. 2004 Jan 19;484(1):103-9.
38. Pentoxifylline attenuation of experimental hepatopulmonary syndrome. Zhang J, etal., J Appl Physiol. 2007 Mar;102(3):949-55. Epub 2006 Nov 16.
39. [Effect and mechanism of salvianolic acid B in attenuating elevated portal pressure in a rat model of portal hypertension induced by endothelin-1]. Zhou Y, etal., Zhong Xi Yi Jie He Xue Bao. 2007 Jan;5(1):61-4.
Additional References at PubMed
PMID:405970   PMID:849800   PMID:1352884   PMID:1378547   PMID:1508194   PMID:2175396   PMID:2246770   PMID:2304907   PMID:2379821   PMID:3996840   PMID:4772386   PMID:4868265  
PMID:5055128   PMID:5320391   PMID:5340422   PMID:5565074   PMID:5713933   PMID:5917257   PMID:5971566   PMID:6049665   PMID:6172311   PMID:7552166   PMID:7632958   PMID:7904485  
PMID:8001159   PMID:8041763   PMID:8129415   PMID:8138159   PMID:8490655   PMID:8548579   PMID:8563573   PMID:8582288   PMID:8583305   PMID:8587354   PMID:8717053   PMID:8722795  
PMID:8783939   PMID:9012511   PMID:9136836   PMID:9371807   PMID:9391239   PMID:9425902   PMID:9434939   PMID:9449665   PMID:9457168   PMID:9495516   PMID:9685680   PMID:9853966  
PMID:9895385   PMID:10021336   PMID:10067171   PMID:10194519   PMID:10198387   PMID:10349636   PMID:10392719   PMID:10444438   PMID:10454512   PMID:10496965   PMID:10517996   PMID:10591209  
PMID:10614578   PMID:10626068   PMID:10645946   PMID:10725249   PMID:10862355   PMID:10922068   PMID:10946246   PMID:10964471   PMID:11042159   PMID:11076861   PMID:11156998   PMID:11217851  
PMID:11413164   PMID:11437453   PMID:11562352   PMID:11773966   PMID:11829485   PMID:11930176   PMID:12160731   PMID:12230499   PMID:12355085   PMID:12370225   PMID:12441350   PMID:12466851  
PMID:12477932   PMID:12574515   PMID:12644183   PMID:12763050   PMID:12812796   PMID:13800713   PMID:13877379   PMID:13943454   PMID:13968171   PMID:14615959   PMID:14659090   PMID:14729956  
PMID:14969349   PMID:15170213   PMID:15201217   PMID:15294878   PMID:15322542   PMID:15489334   PMID:15782199   PMID:15838254   PMID:15838265   PMID:15838300   PMID:15838311   PMID:15838312  
PMID:15838332   PMID:15843399   PMID:15890332   PMID:15892714   PMID:16141072   PMID:16141073   PMID:16339294   PMID:16399858   PMID:16402282   PMID:16412618   PMID:16500897   PMID:16587618  
PMID:16589191   PMID:16602821   PMID:16650841   PMID:16740991   PMID:16782087   PMID:16801484   PMID:16868309   PMID:16919269   PMID:16962346   PMID:17023548   PMID:17090968   PMID:17131407  
PMID:17239249   PMID:17246610   PMID:17246828   PMID:17246842   PMID:17247639   PMID:17607529   PMID:17660396   PMID:17693063   PMID:17726492   PMID:17901218   PMID:18157142   PMID:18199583  
PMID:18218672   PMID:18287559   PMID:18310504   PMID:18340042   PMID:18401410   PMID:18444965   PMID:18524860   PMID:18693272   PMID:18725516   PMID:18784261   PMID:18832397   PMID:19193724  
PMID:19208226   PMID:19299580   PMID:19370413   PMID:19391113   PMID:19493314   PMID:19672104   PMID:19700623   PMID:20048069   PMID:20357223   PMID:20427706   PMID:20501669   PMID:20516393  
PMID:20516397   PMID:20628430   PMID:20628431   PMID:20703215   PMID:21130129   PMID:21156168   PMID:21267068   PMID:21677750   PMID:21715336   PMID:21782343   PMID:21858821   PMID:21873635  
PMID:21918182   PMID:21949113   PMID:21949878   PMID:22067082   PMID:22186729   PMID:22287612   PMID:22309289   PMID:22406076   PMID:22467315   PMID:22810304   PMID:22897442   PMID:23555837  
PMID:23698114   PMID:24043815   PMID:24194353   PMID:24265756   PMID:24412386   PMID:24657829   PMID:24722437   PMID:24756152   PMID:24758835   PMID:24875861   PMID:24945437   PMID:24952961  
PMID:25050930   PMID:25181417   PMID:25487064   PMID:26061883   PMID:26124113   PMID:26238476   PMID:26240367   PMID:26628380   PMID:26824433   PMID:26863197   PMID:27026367   PMID:27134165  
PMID:27209208   PMID:27280426   PMID:27294512   PMID:27370713   PMID:27881779   PMID:27905407   PMID:28028193   PMID:28063956   PMID:28067313   PMID:28539637   PMID:28700113   PMID:28779103  
PMID:28797761   PMID:28983681   PMID:29018955   PMID:29031500   PMID:29196262   PMID:29513653   PMID:29570803   PMID:29678817   PMID:30069745   PMID:30635555   PMID:30872278   PMID:30908942  
PMID:31248984   PMID:31657718   PMID:31847788   PMID:31923844   PMID:31924792   PMID:32358570   PMID:32518258   PMID:32592286   PMID:32809970   PMID:32848868   PMID:33057196   PMID:33159498  
PMID:33340715   PMID:33443158   PMID:33707239   PMID:33958373   PMID:34003106   PMID:34272903   PMID:34274976   PMID:34292881   PMID:34321664   PMID:34321999   PMID:34767447   PMID:35175194  
PMID:35429992   PMID:35568059   PMID:35757687   PMID:35831953   PMID:36343245   PMID:36396948   PMID:36868194  


Genomics

Comparative Map Data
Ednrb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3914104,052,051 - 104,083,248 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl14104,052,061 - 104,081,838 (-)EnsemblGRCm39 Ensembl
GRCm3814103,814,615 - 103,844,508 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl14103,814,625 - 103,844,402 (-)EnsemblGRCm38mm10GRCm38
MGSCv3714104,213,842 - 104,243,390 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3614102,700,305 - 102,729,375 (-)NCBIMGSCv36mm8
Celera14102,434,540 - 102,464,042 (-)NCBICelera
Cytogenetic Map14E2.3NCBI
cM Map1453.05NCBI
EDNRB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381377,895,481 - 77,975,527 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1377,895,481 - 77,975,529 (-)EnsemblGRCh38hg38GRCh38
GRCh371378,469,616 - 78,549,662 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361377,367,617 - 77,447,665 (-)NCBINCBI36Build 36hg18NCBI36
Build 341377,368,543 - 77,390,935NCBI
Celera1359,367,540 - 59,390,895 (-)NCBICelera
Cytogenetic Map13q22.3NCBI
HuRef1359,168,348 - 59,248,390 (-)NCBIHuRef
CHM1_11378,436,966 - 78,516,998 (-)NCBICHM1_1
T2T-CHM13v2.01377,120,403 - 77,200,427 (-)NCBIT2T-CHM13v2.0
Ednrb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21580,640,839 - 80,672,115 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1580,643,043 - 80,672,115 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1584,622,892 - 84,651,923 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01585,745,953 - 85,774,986 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01582,673,598 - 82,702,629 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01588,004,775 - 88,036,354 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1588,006,977 - 88,036,354 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01591,500,400 - 91,531,979 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41587,893,141 - 87,898,700 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11587,908,924 - 87,914,471 (-)NCBI
Celera1579,772,740 - 79,801,760 (-)NCBICelera
RH 3.4 Map15496.21RGD
Cytogenetic Map15q22NCBI
Ednrb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540429,394,164 - 29,425,358 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540429,394,253 - 29,425,358 (+)NCBIChiLan1.0ChiLan1.0
EDNRB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan11378,060,299 - 78,084,570 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01359,112,349 - 59,136,615 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11378,153,026 - 78,177,281 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1378,153,020 - 78,177,286 (-)Ensemblpanpan1.1panPan2
EDNRB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12231,415,324 - 31,438,772 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2231,417,308 - 31,437,587 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2231,277,699 - 31,297,545 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02231,733,123 - 31,756,544 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2231,733,292 - 31,756,408 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12231,396,562 - 31,416,398 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02231,434,803 - 31,454,631 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02231,507,052 - 31,526,893 (-)NCBIUU_Cfam_GSD_1.0
Ednrb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945128,029,566 - 128,061,207 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365113,446,839 - 3,478,434 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365113,446,864 - 3,478,434 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EDNRB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1150,072,554 - 50,102,884 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11150,073,300 - 50,102,879 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21154,689,465 - 54,718,898 (-)NCBISscrofa10.2Sscrofa10.2susScr3
EDNRB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1356,969,493 - 56,993,719 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl356,969,101 - 56,992,731 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604613,190,167 - 13,214,545 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ednrb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475122,459,584 - 22,491,606 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475122,459,613 - 22,491,409 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ednrb
808 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1406
Count of miRNA genes:424
Interacting mature miRNAs:514
Transcripts:ENSMUST00000022718, ENSMUST00000172237
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357589Kdnw2_mkidney weight 2 (mouse)Not determined1420887473121269804Mouse
14747006Mancz12_mmandible centroid size 12 (mouse)1470071977104071977Mouse
10054475Ossc3_mosteosarcoma susceptibility 3 (mouse)Not determined1470863768104863926Mouse
1300551Lprm3_mlymphoproliferation modifier 3 (mouse)Not determined1471221224105221344Mouse
1301844Pgia29_mproteoglycan induced arthritis 29 (mouse)Not determined1474352296108352384Mouse
1558819Ossc2_mosteosarcoma susceptibility 2 (mouse)Not determined1474394976108395093Mouse
14928314Manh77_mmandible shape 77 (mouse)1476767790110767790Mouse
1558823Tbbmd6_mtotal body bone mineral density 6 (mouse)Not determined1477073696111073787Mouse
4142508Tgq25_mtriglyceride QTL 25 (mouse)Not determined85134068119134068Mouse
12792981Fbmd5_mfemoral bone mineral density 5, females only (mouse)1499838217125033054Mouse

Markers in Region
U32329  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3814103,816,845 - 103,817,011UniSTSGRCm38
MGSCv3714104,216,062 - 104,216,228UniSTSGRCm37
Celera14102,436,765 - 102,436,931UniSTS
Cytogenetic Map14E2.3UniSTS
Whitehead/MRC_RH141087.31UniSTS
Whitehead/MRC_RH141095.2UniSTS
Whitehead_YAC5 UniSTS
AU022549  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3814103,814,753 - 103,814,878UniSTSGRCm38
MGSCv3714104,213,970 - 104,214,095UniSTSGRCm37
Celera14102,434,668 - 102,434,793UniSTS
Cytogenetic Map14E2.3UniSTS
Whitehead/MRC_RH141090.82UniSTS
PMC24270P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3814103,816,989 - 103,817,200UniSTSGRCm38
MGSCv3714104,216,206 - 104,216,417UniSTSGRCm37
Celera14102,436,909 - 102,437,120UniSTS
Cytogenetic Map14E2.3UniSTS
Ednrb  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map14E2.3UniSTS
cM Map1451.0UniSTS
Ednrb  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3814103,820,798 - 103,820,914UniSTSGRCm38
MGSCv3714104,220,015 - 104,220,131UniSTSGRCm37
Celera14102,440,718 - 102,440,834UniSTS
Cytogenetic Map14E2.3UniSTS
cM Map1451.0UniSTS
U32329  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3814103,816,858 - 103,816,995UniSTSGRCm38
MGSCv3714104,216,075 - 104,216,212UniSTSGRCm37
Celera14102,436,778 - 102,436,915UniSTS
Cytogenetic Map14E2.3UniSTS
Whitehead/MRC_RH141087.31UniSTS
Whitehead/MRC_RH141095.2UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001136061 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001276296 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001422171 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001422172 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_007904 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006518515 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB242436 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC110092 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC154670 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK076426 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK082103 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK083415 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK085165 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK085532 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK189863 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK189874 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK189945 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK189968 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK190192 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK190249 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK190427 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK190442 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK190640 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK190876 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK191270 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK191663 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK191900 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK191926 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK192059 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK192307 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK192781 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK192804 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK192914 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK192971 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK193707 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK193958 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK194687 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK194698 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK195149 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK195461 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK195495 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK195678 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK195876 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK196408 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK196702 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK197542 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK197551 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK198045 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK198133 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK198226 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK198341 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK198432 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK198475 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK198522 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK198545 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK198684 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK198739 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK199045 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK199128 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK199342 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK199447 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK200182 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK200557 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK201319 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK201399 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK201440 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK201511 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK202082 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK202128 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK202614 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK202768 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK202909 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK203096 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK204265 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK204405 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK204434 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK204711 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK205400 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK206106 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK206254 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK208708 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK210167 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK211542 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK211790 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK213746 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK214403 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK215228 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK215471 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK215811 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK215891 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK218093 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK219164 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB003851 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC026553 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ442271 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466544 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U32329 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSMUST00000022718   ⟹   ENSMUSP00000022718
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl14104,052,061 - 104,081,838 (-)Ensembl
GRCm38.p6 Ensembl14103,814,625 - 103,844,402 (-)Ensembl
RefSeq Acc Id: ENSMUST00000172237   ⟹   ENSMUSP00000126057
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl14104,052,062 - 104,081,132 (-)Ensembl
GRCm38.p6 Ensembl14103,814,626 - 103,843,696 (-)Ensembl
RefSeq Acc Id: ENSMUST00000227824   ⟹   ENSMUSP00000154806
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl14104,052,164 - 104,081,131 (-)Ensembl
GRCm38.p6 Ensembl14103,814,728 - 103,843,695 (-)Ensembl
RefSeq Acc Id: NM_001136061   ⟹   NP_001129533
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3914104,052,051 - 104,081,912 (-)NCBI
GRCm3814103,814,615 - 103,844,476 (-)NCBI
MGSCv3714104,213,842 - 104,243,390 (-)RGD
Celera14102,434,530 - 102,464,345 (-)NCBI
cM Map14 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001276296   ⟹   NP_001263225
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3914104,052,051 - 104,081,137 (-)NCBI
GRCm3814103,814,615 - 103,843,701 (-)NCBI
Celera14102,434,530 - 102,464,345 (-)NCBI
Sequence:
RefSeq Acc Id: NM_007904   ⟹   NP_031930
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3914104,052,051 - 104,081,137 (-)NCBI
GRCm3814103,814,615 - 103,843,701 (-)NCBI
MGSCv3714104,213,842 - 104,243,390 (-)RGD
Celera14102,434,530 - 102,464,345 (-)NCBI
cM Map14 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006518515   ⟹   XP_006518578
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3914104,052,052 - 104,083,248 (-)NCBI
GRCm3814103,814,616 - 103,844,508 (-)NCBI
Sequence:
RefSeq Acc Id: NP_031930   ⟸   NM_007904
- Peptide Label: precursor
- UniProtKB: Q542M3 (UniProtKB/Swiss-Prot),   P48302 (UniProtKB/Swiss-Prot),   Q8K1V9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001129533   ⟸   NM_001136061
- Peptide Label: precursor
- UniProtKB: Q542M3 (UniProtKB/Swiss-Prot),   P48302 (UniProtKB/Swiss-Prot),   Q8K1V9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001263225   ⟸   NM_001276296
- Peptide Label: precursor
- UniProtKB: Q542M3 (UniProtKB/Swiss-Prot),   P48302 (UniProtKB/Swiss-Prot),   Q8K1V9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006518578   ⟸   XM_006518515
- Peptide Label: isoform X1
- UniProtKB: P48302 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000126057   ⟸   ENSMUST00000172237
RefSeq Acc Id: ENSMUSP00000154806   ⟸   ENSMUST00000227824
RefSeq Acc Id: ENSMUSP00000022718   ⟸   ENSMUST00000022718
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P48302-F1-model_v2 AlphaFold P48302 1-442 view protein structure

Promoters
RGD ID:8683150
Promoter ID:EPDNEW_M19606
Type:multiple initiation site
Name:Ednrb_1
Description:Mus musculus endothelin receptor type B , transcript variant2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M19607  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3814103,843,694 - 103,843,754EPDNEW
RGD ID:8683154
Promoter ID:EPDNEW_M19607
Type:initiation region
Name:Ednrb_2
Description:Mus musculus endothelin receptor type B , transcript variant2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M19606  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3814103,844,328 - 103,844,388EPDNEW
RGD ID:6824853
Promoter ID:MM_KWN:17685
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney,   Lung,   Spleen
Transcripts:ENSMUST00000088530,   NM_007904,   UC007UWX.1,   UC007UWY.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3614104,242,636 - 104,244,587 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:102720 AgrOrtholog
Ensembl Genes ENSMUSG00000022122 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000022718 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000172237 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000227824 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Endthln_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ETB_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:13618 UniProtKB/Swiss-Prot
MGD MGI:102720 ENTREZGENE
NCBI Gene 13618 ENTREZGENE
PANTHER ENDOTHELIN RECEPTOR TYPE B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 DOMAIN-CONTAINING PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB EDNRB RGD
PhenoGen Ednrb PhenoGen
PRINTS ENDOTHELINBR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENDOTHELINR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt EDNRB_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q542M3 ENTREZGENE
  Q8BJE1_MOUSE UniProtKB/TrEMBL
  Q8K1V9 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q542M3 UniProtKB/Swiss-Prot