Edn1 (endothelin 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Edn1 (endothelin 1) Mus musculus
Analyze
Symbol: Edn1
Name: endothelin 1
RGD ID: 10499
MGI Page MGI
Description: Enables endothelin A receptor binding activity and receptor ligand activity. Involved in several processes, including cellular response to gonadotropin stimulus; circulatory system development; and neuron differentiation. Acts upstream of or within several processes, including G protein-coupled receptor signaling pathway; middle ear morphogenesis; and renal albumin absorption. Is active in extracellular space. Is expressed in several structures, including branchial arch; cardiovascular system; central nervous system; gut; and sensory organ. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); lung disease (multiple); obesity; obstructive sleep apnea; and rheumatoid arthritis. Orthologous to human EDN1 (endothelin 1).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: endothelin-1; ET-1; PPET1; preproendothelin; preproendothelin-1; preproET
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391342,454,952 - 42,461,466 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1342,454,952 - 42,461,466 (+)EnsemblGRCm39 Ensembl
GRCm381342,301,476 - 42,307,990 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1342,301,476 - 42,307,990 (+)EnsemblGRCm38mm10GRCm38
MGSCv371342,396,639 - 42,403,358 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361342,312,448 - 42,318,962 (+)NCBIMGSCv36mm8
Celera1343,379,939 - 43,386,658 (+)NCBICelera
Cytogenetic Map13A4NCBI
cM Map1320.82NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (IEP,ISO)
Acute Lung Injury  (ISO)
adult respiratory distress syndrome  (ISO)
Albuminuria  (ISO)
angle-closure glaucoma  (ISO)
anterolateral myocardial infarction  (ISO)
aortic atherosclerosis  (ISO)
aspiration pneumonia  (ISO)
asthma  (ISO)
atherosclerosis  (IDA)
atrial fibrillation  (ISO)
Auriculocondylar Syndrome  (ISO)
Auriculocondylar Syndrome 3  (ISO)
autosomal dominant polycystic kidney disease  (ISO)
basal cell carcinoma  (ISO)
Behcet's disease  (ISO)
Bradycardia  (ISO)
brain ischemia  (ISO)
bronchiolitis obliterans  (ISO)
bronchopulmonary dysplasia  (ISO)
Cardiac Arrhythmias  (ISO)
Cardiac Fibrosis  (ISO)
Cardiomegaly  (ISO)
cardiomyopathy  (ISO)
Cardiovascular Abnormalities  (ISO)
cardiovascular system disease  (ISO)
cartilage disease  (ISO)
cerebrovascular disease  (ISO)
Chronic Bronchitis  (IEP)
chronic obstructive pulmonary disease  (ISO)
chronic rhinitis  (ISO)
Chronic Tubulointerstitial Nephropathy  (ISO)
congenital heart disease  (ISO)
congestive heart failure  (ISO)
coronary artery disease  (ISO)
coronary stenosis  (ISO)
Craniofacial Abnormalities  (IMP,ISO)
cystic fibrosis  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
Diaphragmatic Hernia  (ISO)
dilated cardiomyopathy  (ISO)
Dyspnea  (ISO)
end stage renal disease  (ISO)
Endotoxemia  (ISO)
exfoliation syndrome  (ISO)
Experimental Arthritis  (IEP)
Experimental Diabetes Mellitus  (IDA,ISO)
Experimental Liver Cirrhosis  (ISO)
focal segmental glomerulosclerosis  (ISO)
gastrointestinal system disease  (ISO)
genetic disease  (ISO)
heart disease  (ISO)
hepatopulmonary syndrome  (ISO)
hepatorenal syndrome  (ISO)
Hyperalgesia  (IEP,IMP,ISO)
Hypercapnia  (IMP,ISO)
Hypercholesterolemia  (ISO)
Hyperoxia  (ISO)
hypertension  (ISO)
hypertrophic cardiomyopathy  (ISO)
Hypertrophy  (ISO)
hypogonadism  (ISO)
Hypotension  (IMP,ISO)
impotence  (ISO)
Inflammation  (ISO)
intermediate coronary syndrome  (ISO)
intracranial aneurysm  (ISO)
kidney disease  (ISO)
kidney failure  (ISO)
Left Ventricular Hypertrophy  (ISO)
Lewy body dementia  (ISO)
liver cirrhosis  (ISO)
low tension glaucoma  (ISO)
major depressive disorder  (ISO)
membranoproliferative glomerulonephritis  (ISO)
metabolic acidosis  (ISO)
middle cerebral artery infarction  (ISO)
multiple sclerosis  (ISO)
myocardial infarction  (ISO)
Myocardial Ischemia  (ISO)
Myocardial Reperfusion Injury  (ISO)
Neoplasm Metastasis  (IDA)
Neoplastic Cell Transformation  (ISO)
neovascular glaucoma  (ISO)
neovascular inflammatory vitreoretinopathy  (ISO)
nephritis  (ISO)
nephrosis  (ISO)
nephrotic syndrome  (ISO)
obesity  (ISO)
obstructive sleep apnea  (ISO)
optic nerve disease  (ISO)
Optic Nerve Injuries  (ISO)
Oral Ulcer  (ISO)
ovarian carcinoma  (ISO)
overactive bladder syndrome  (ISO)
Pain  (ISO)
Parkinson's disease  (ISO)
peptic ulcer disease  (ISO)
pneumonia  (ISO)
Pneumoperitoneum  (ISO)
portal hypertension  (ISO)
pre-eclampsia  (ISO)
Pregnancy-Induced Hypertension  (ISO)
Premature Birth  (ISO)
Presbycusis  (ISO)
primary open angle glaucoma  (ISO)
pulmonary embolism  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (IEP,ISO)
Question Mark Ears, Isolated  (ISO)
renal artery disease  (ISO)
Reperfusion Injury  (ISO)
retinal degeneration  (IEP,IMP)
retinal detachment  (ISO)
retinitis pigmentosa  (ISO)
rheumatoid arthritis  (ISO)
Sepsis  (ISO)
Slow Coronary Flow  (ISO)
Stroke  (ISO)
Subarachnoid Hemorrhage  (ISO)
systemic scleroderma  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
uremia  (ISO)
ureteral obstruction  (ISO)
Urinary Retention  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (EXP,ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(R)-noradrenaline  (ISO)
(S)-nicotine  (EXP)
1,2-dimethylhydrazine  (EXP)
1,3-dinitrobenzene  (ISO)
11-deoxycorticosterone  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
1D-myo-inositol 1,4,5-trisphosphate  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine  (ISO)
2-butoxyethanol  (EXP)
2-tert-butylhydroquinone  (ISO)
3',5'-cyclic GMP  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxy-TEMPO  (EXP,ISO)
4-hydroxynon-2-enal  (EXP)
4-hydroxyphenyl retinamide  (EXP)
5-fluorouracil  (ISO)
5-formyltetrahydrofolic acid  (EXP)
6-propyl-2-thiouracil  (ISO)
6alpha-methylprednisolone  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
7-nitroindazole  (ISO)
8-bromo-3',5'-cyclic GMP  (ISO)
acetamide  (ISO)
acetylcholine  (ISO)
acrolein  (ISO)
actinomycin D  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
agmatine  (ISO)
aldehydo-D-glucose  (ISO)
aldosterone  (ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-Zearalanol  (ISO)
aminoguanidine  (ISO)
amlodipine  (ISO)
ammonium chloride  (ISO)
ampicillin  (ISO)
andrographolide  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
apocynin  (EXP,ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (EXP)
arsenous acid  (ISO)
asbestos  (ISO)
atenolol  (ISO)
atorvastatin calcium  (ISO)
atrasentan  (ISO)
atropine  (ISO)
Azoxymethane  (EXP)
Bardoxolone methyl  (ISO)
belinostat  (ISO)
benazepril  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-carotene  (EXP)
beta-lapachone  (ISO)
bezafibrate  (ISO)
bilirubin IXalpha  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bleomycin A2  (ISO)
bosentan  (ISO)
BQ 123  (EXP,ISO)
BQ 485  (ISO)
buta-1,3-diene  (EXP)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caesium chloride  (ISO)
caffeine  (ISO)
Calcimycin  (ISO)
calcitriol  (ISO)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
Calphostin C  (ISO)
Candesartan cilexetil  (ISO)
capsaicin  (ISO)
carbon atom  (ISO)
carbon monoxide  (EXP,ISO)
carbon nanotube  (EXP,ISO)
carvedilol  (ISO)
CGS-21680  (EXP)
chelerythrine  (ISO)
chenodeoxycholic acid  (ISO)
chetomin  (ISO)
chlordecone  (EXP)
chlorpyrifos  (EXP)
choline  (EXP)
chromium(6+)  (EXP)
chrysin  (ISO)
cicaprost  (ISO)
cis-caffeic acid  (EXP)
cisplatin  (EXP,ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
cocaine  (ISO)
coenzyme Q10  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
corticosterone  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cycloheximide  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
cytarabine  (EXP,ISO)
D-glucose  (ISO)
dantrolene  (ISO)
dapsone  (EXP)
daunorubicin  (ISO)
Deoxycorticosterone acetate  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP)
diallyl disulfide  (ISO)
diarsenic trioxide  (ISO)
dibenziodolium  (EXP,ISO)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (EXP,ISO)
diclofenac  (EXP)
diethyl phthalate  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dimethylarsinic acid  (EXP)
dimethylarsinous acid  (ISO)
dioxygen  (EXP,ISO)
diprotium oxide  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
dydrogesterone  (ISO)
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor  (ISO)
elemental carbon  (ISO)
enalapril  (ISO)
enalaprilat dihydrate  (ISO)
endosulfan  (ISO)
entinostat  (ISO)
ethanol  (EXP,ISO)
etoposide  (ISO)
fenofibrate  (EXP,ISO)
fluoranthene  (EXP)
folic acid  (EXP)
formaldehyde  (ISO)
fructose  (ISO)
fulvestrant  (ISO)
furan  (ISO)
geldanamycin  (ISO)
gemcitabine  (ISO)
genistein  (ISO)
gentamycin  (ISO)
Gingerenone A  (ISO)
glucose  (ISO)
glyburide  (ISO)
glycidol  (ISO)
glycoursodeoxycholic acid  (ISO)
GW 4064  (ISO)
heparin  (ISO)
hexadecanoic acid  (ISO)
histamine  (ISO)
homocysteine  (ISO)
hydralazine  (ISO)
hydrochlorothiazide  (ISO)
hydrogen chloride  (ISO)
hydrogen peroxide  (ISO)
hydrogen sulfide  (EXP)
hydroquinone  (ISO)
ICI 118551  (ISO)
indometacin  (ISO)
iodixanol  (ISO)
iopromide  (ISO)
irbesartan  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
iron(III) citrate  (ISO)
isoprenaline  (ISO)
isoquinoline-1,5-diol  (ISO)
isorhamnetin  (ISO)
isosorbide dinitrate  (ISO)
ivermectin  (ISO)
KT 5823  (ISO)
L-ascorbic acid  (ISO)
L-mimosine  (ISO)
lactiflorin  (ISO)
lamivudine  (ISO)
leflunomide  (EXP)
leukotriene C4  (ISO)
levamisole  (ISO)
linalool  (ISO)
linoleic acid  (ISO)
lipopolysaccharide  (EXP,ISO)
lisinopril dihydrate  (ISO)
losartan  (ISO)
LY294002  (ISO)
Magnolol  (ISO)
malathion  (ISO)
manganese(II) chloride  (ISO)
Meglumine sodium amidotrizoate  (ISO)
melphalan  (ISO)
menadione  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (ISO)
metformin  (EXP,ISO)
methotrexate  (ISO)
methoxychlor  (ISO)
methyl 2-methylpropyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate  (ISO)
methyl beta-cyclodextrin  (EXP)
methylarsonic acid  (EXP)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
metoprolol  (ISO)
mevalonic acid  (ISO)
Mibefradil  (ISO)
microcystin-LR  (EXP)
MK-2206  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monocrotaline  (ISO)
montelukast  (ISO)
N(gamma)-nitro-L-arginine methyl ester  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (ISO)
naphthalene  (EXP)
nebivolol  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
nicotine  (EXP)
nicotinic acid-adenine dinucleotide phosphate  (EXP)
nifedipine  (ISO)
nimesulide  (ISO)
nisoldipine  (ISO)
nitric oxide  (EXP,ISO)
nitrofen  (EXP,ISO)
nitrogen dioxide  (EXP)
nitroglycerin  (ISO)
nitroprusside  (ISO)
Nutlin-3  (ISO)
ochratoxin A  (ISO)
octadecanoic acid  (ISO)
oleic acid  (ISO)
Olmesartan medoxomil  (ISO)
olodaterol  (ISO)
orotic acid  (ISO)
oroxylin A  (ISO)
ouabain  (ISO)
Oxotremorine  (ISO)
ozone  (EXP,ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
paricalcitol  (ISO)
PD123319  (ISO)
phenethyl caffeate  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (ISO)
phenylephrine  (ISO)
phenylmercury acetate  (ISO)
PhIP  (ISO)
phosgene  (ISO)
phosphoramide mustard  (ISO)
phosphoramidon  (ISO)
picrotoxin  (ISO)
pifithrin-alpha hydrobromide  (ISO)
potassium atom  (EXP)
potassium chloride  (ISO)
potassium chromate  (ISO)
pravastatin  (ISO)
prazosin  (ISO)
progesterone  (EXP,ISO)
propofol  (ISO)
prostaglandin E2  (EXP,ISO)
quartz  (ISO)
quercetin  (EXP,ISO)
quinapril hydrochloride  (ISO)
reactive oxygen species  (ISO)
rebaudioside A  (ISO)
RES-701-1  (ISO)
resveratrol  (EXP,ISO)
rifampicin  (ISO)
Ro 31-8220  (ISO)
rolipram  (ISO)
rotenone  (ISO)
ruxolitinib  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-methyl-L-thiocitrulline  (ISO)
S-nitroso-N-acetyl-D-penicillamine  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
sevoflurane  (ISO)
sildenafil citrate  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
sirolimus  (ISO)
sodium arsenate  (EXP)
sodium arsenite  (EXP,ISO)
sodium atom  (EXP)
sodium chloride  (ISO)
sodium dodecyl sulfate  (ISO)
sorafenib  (ISO)
stattic  (ISO)
staurosporine  (ISO)
steviol  (ISO)
stevioside  (ISO)
stilbene-4,4'-diol  (ISO)
streptozocin  (ISO)
Sucralfate  (ISO)
sulfur dioxide  (EXP,ISO)
sunitinib  (ISO)
superoxide  (EXP,ISO)
tacrolimus hydrate  (ISO)
tamibarotene  (ISO)
tamoxifen  (EXP,ISO)
Tanshinone I  (ISO)
tauroursodeoxycholic acid  (ISO)
telmisartan  (ISO)
temozolomide  (ISO)
tenofovir disoproxil fumarate  (ISO)
teprenone  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
tetracosanoic acid  (ISO)
tetraphene  (EXP)
Theaflavin 3,3'-digallate  (ISO)
theophylline  (ISO)
thioacetamide  (ISO)
thiram  (ISO)
thymidine  (ISO)
tiotropium bromide  (ISO)
Tiron  (EXP)
titanium dioxide  (EXP)
torcetrapib  (ISO)
trans-caffeic acid  (EXP)
trans-stilbene-4,4'-diol  (ISO)
triadimefon  (ISO)
tributylstannane  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
troglitazone  (ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
tyrphostin AG 1478  (EXP,ISO)
U-73122  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (ISO)
ursolic acid  (EXP)
valproic acid  (EXP,ISO)
valsartan  (ISO)
vanadyl sulfate  (ISO)
verapamil  (ISO)
vinclozolin  (ISO)
water  (EXP)
wortmannin  (EXP)
Y-27632  (ISO)
zafirlukast  (ISO)
zidovudine  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway  (IDA,IGI)
artery smooth muscle contraction  (IEA,ISO)
axon extension  (IDA)
axon guidance  (IMP)
axonogenesis involved in innervation  (IMP)
blood vessel diameter maintenance  (IEA)
blood vessel morphogenesis  (IMP)
body fluid secretion  (IMP)
branching involved in blood vessel morphogenesis  (IMP)
calcium ion transmembrane transport  (IDA)
calcium-mediated signaling  (IEA,ISO)
cAMP/PKA signal transduction  (IEA,ISO)
canonical Wnt signaling pathway  (IDA)
cardiac neural crest cell migration involved in outflow tract morphogenesis  (IDA)
cartilage development  (IMP)
cell surface receptor signaling pathway  (IEA,ISO)
cell-cell signaling  (IEA,ISO)
cellular response to calcium ion  (IEA,ISO)
cellular response to fatty acid  (IEA,ISO)
cellular response to follicle-stimulating hormone stimulus  (IDA)
cellular response to glucocorticoid stimulus  (IEA,ISO)
cellular response to human chorionic gonadotropin stimulus  (IDA)
cellular response to hydrogen peroxide  (IEA,ISO)
cellular response to hypoxia  (IEA,ISO)
cellular response to interleukin-1  (IEA,ISO)
cellular response to luteinizing hormone stimulus  (IDA)
cellular response to mineralocorticoid stimulus  (IEA,ISO)
cellular response to peptide hormone stimulus  (IEA,ISO)
cellular response to toxic substance  (IDA,IEA,IMP,ISO)
cellular response to transforming growth factor beta stimulus  (IEA,ISO)
cellular response to tumor necrosis factor  (IEA,ISO)
cellular response to type II interferon  (IEA,ISO)
cellular response to xenobiotic stimulus  (IEA,ISO)
dorsal/ventral pattern formation  (IMP)
embryonic heart tube development  (IMP)
endothelin receptor signaling pathway  (IDA,IEA,IGI,ISO,ISS)
endothelin receptor signaling pathway involved in heart process  (IDA)
epithelial fluid transport  (IEA,ISO)
ERK1 and ERK2 cascade  (IDA)
establishment of endothelial barrier  (IDA)
G protein-coupled receptor signaling pathway  (IEA,ISO,TAS)
gene expression  (IDA,IMP)
glomerular endothelium development  (IDA)
glomerular filtration  (IDA)
heart development  (IMP)
heart process  (IMP)
heparin proteoglycan metabolic process  (IDA,IMP)
histamine secretion  (IEA,ISO)
in utero embryonic development  (IMP)
intracellular calcium ion homeostasis  (IBA,IDA,IEA,ISO)
intracellular signal transduction  (IEA,ISO)
MAPK cascade  (IDA,IMP)
maternal process involved in parturition  (IEA,ISO)
meiotic cell cycle process involved in oocyte maturation  (IDA)
membrane depolarization  (IEA,ISO)
middle ear morphogenesis  (IMP)
mitochondrion organization  (IDA)
negative regulation of gene expression  (IEA,ISO)
negative regulation of hormone secretion  (IEA,ISO)
negative regulation of phospholipase C/protein kinase C signal transduction  (IEA,ISO)
negative regulation of protein metabolic process  (IEA,ISO)
negative regulation of smooth muscle cell apoptotic process  (IEA,ISO)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
neural crest cell development  (IMP)
neural crest cell differentiation  (IMP)
neural crest cell fate commitment  (IMP)
neuron projection development  (IDA)
neutrophil chemotaxis  (ISO)
nitric oxide transport  (IEA,ISO)
noradrenergic neuron differentiation  (IMP)
peptide hormone secretion  (IEA,ISO)
pharyngeal arch artery morphogenesis  (IMP)
phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA,ISO)
phospholipase C-activating G protein-coupled receptor signaling pathway  (IDA)
phospholipase D-activating G protein-coupled receptor signaling pathway  (IDA)
podocyte differentiation  (IDA,IGI)
positive regulation of artery morphogenesis  (IMP)
positive regulation of calcium-mediated signaling  (IEA,ISO)
positive regulation of canonical NF-kappaB signal transduction  (IDA)
positive regulation of cardiac muscle hypertrophy  (IEA,ISO)
positive regulation of cation channel activity  (ISO)
positive regulation of cell growth involved in cardiac muscle cell development  (IEA,ISO)
positive regulation of cell migration  (IEA,ISO)
positive regulation of cell population proliferation  (IDA,IEA,ISO)
positive regulation of cell size  (IEA,ISO)
positive regulation of chemokine-mediated signaling pathway  (IEA,ISO)
positive regulation of cytosolic calcium ion concentration  (IEA,ISO)
positive regulation of heart rate  (IEA,ISO)
positive regulation of hormone secretion  (IEA,ISO)
positive regulation of JNK cascade  (IEA,ISO)
positive regulation of MAPK cascade  (IEA,ISO)
positive regulation of mitotic nuclear division  (IEA,ISO)
positive regulation of neutrophil chemotaxis  (IEA,ISO)
positive regulation of non-canonical NF-kappaB signal transduction  (IEA,ISO)
positive regulation of odontogenesis  (IEA,ISO)
positive regulation of prostaglandin biosynthetic process  (IEA,ISO)
positive regulation of prostaglandin secretion  (IEA,ISO)
positive regulation of protein localization to nucleus  (IMP)
positive regulation of renal sodium excretion  (IMP)
positive regulation of sarcomere organization  (IEA,ISO)
positive regulation of smooth muscle cell proliferation  (IEA,ISO)
positive regulation of smooth muscle contraction  (IBA,IDA,IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
positive regulation of urine volume  (IGI,IMP)
positive regulation of vascular associated smooth muscle cell proliferation  (IEA,ISO)
protein phosphorylation  (IDA)
protein transmembrane transport  (IMP)
regulation of blood pressure  (IEA,IMP,ISO)
regulation of D-glucose transmembrane transport  (IDA)
regulation of pH  (IDA)
regulation of systemic arterial blood pressure by endothelin  (IBA,IEA,ISO)
regulation of vasoconstriction  (IEA)
renal albumin absorption  (IGI)
renal sodium ion absorption  (IDA)
respiratory gaseous exchange by respiratory system  (IMP)
response to activity  (IEA,ISO)
response to amino acid  (IEA,ISO)
response to amphetamine  (IMP)
response to dexamethasone  (IEA,ISO)
response to hypoxia  (IEA,IMP,ISO)
response to leptin  (IEA,ISO)
response to lipopolysaccharide  (IEA,ISO)
response to muscle stretch  (IEA,ISO)
response to nicotine  (IEA,ISO)
response to ozone  (IEA,ISO)
response to prostaglandin F  (IEA,ISO)
response to salt  (IEA,ISO)
response to testosterone  (IEA,ISO)
response to transforming growth factor beta  (IEA,ISO)
response to xenobiotic stimulus  (IEA,ISO)
rhythmic excitation  (IMP)
semaphorin-plexin signaling pathway involved in axon guidance  (IMP)
signal transduction involved in regulation of gene expression  (IEA,ISO)
skeletal system development  (IMP)
smooth muscle contraction  (IDA)
superoxide anion generation  (IEA,ISO)
sympathetic neuron axon guidance  (IMP)
thyroid gland development  (IMP)
transcription by RNA polymerase II  (IDA)
vasoconstriction  (IEA,ISO)
vein smooth muscle contraction  (IBA,IEA,ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal aorta morphology  (IAGP)
abnormal blood gas level  (IAGP)
abnormal cardiovascular system morphology  (IAGP)
abnormal carotid artery morphology  (IAGP)
abnormal craniofacial morphology  (IAGP)
abnormal first pharyngeal arch morphology  (IAGP)
abnormal fourth pharyngeal arch artery morphology  (IAGP)
abnormal hyoid bone morphology  (IAGP)
abnormal kidney physiology  (IAGP)
abnormal Meckel's cartilage morphology  (IAGP)
abnormal middle ear morphology  (IAGP)
abnormal neck muscle morphology  (IAGP)
abnormal pharyngeal arch artery morphology  (IAGP)
abnormal sympathetic nervous system physiology  (IAGP)
abnormal tongue morphology  (IAGP)
abnormal tongue muscle morphology  (IAGP)
abnormal urine homeostasis  (IAGP)
absent hyoid bone  (IAGP)
absent outer ear  (IAGP)
absent right subclavian artery  (IAGP)
absent submandibular gland  (IAGP)
aorta tubular hypoplasia  (IAGP)
cleft chin  (IAGP)
cleft palate  (IAGP)
decreased circulating antidiuretic hormone level  (IAGP)
decreased circulating sodium level  (IAGP)
decreased mean systemic arterial blood pressure  (IAGP)
decreased response of heart to induced stress  (IAGP)
decreased systemic arterial diastolic blood pressure  (IAGP)
decreased systemic arterial systolic blood pressure  (IAGP)
decreased urine sodium level  (IAGP)
dilated heart right ventricle  (IAGP)
double outlet right ventricle  (IAGP)
hypercapnia  (IAGP)
hypertension  (IAGP)
hypoxia  (IAGP)
increased mean systemic arterial blood pressure  (IAGP)
increased systemic arterial blood pressure  (IAGP)
increased systemic arterial systolic blood pressure  (IAGP)
increased urine osmolality  (IAGP)
interrupted aorta  (IAGP)
mandible hypoplasia  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
no abnormal phenotype detected  (IAGP)
oliguria  (IAGP)
overriding aortic valve  (IAGP)
perinatal lethality, complete penetrance  (IAGP)
salt-sensitive hypertension  (IAGP)
small second pharyngeal arch  (IAGP)
ventricular septal defect  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Increased levels of endothelin-1 and differential endothelin type A and B receptor expression in scleroderma-associated fibrotic lung disease. Abraham DJ, etal., Am J Pathol. 1997 Sep;151(3):831-41.
2. Maternal EDN1 G5665T polymorphism influences circulating endothelin-1 levels and plays a role in determination of preeclampsia phenotype. Aggarwal PK, etal., J Hypertens. 2009 Oct;27(10):2044-50.
3. Pneumoperitoneum upregulates preproendothelin-1 messenger RNA. Ambrose JA, etal., Surg Endosc. 2001 Feb;15(2):183-8.
4. Endothelin-1 and its binding sites are upregulated in pressure overload cardiac hypertrophy. Arai M, etal., Am J Physiol. 1995 May;268(5 Pt 2):H2084-91.
5. Telmisartan prevents the progression of renal injury in daunorubicin rats with the alteration of angiotensin II and endothelin-1 receptor expression associated with its PPAR-gamma agonist actions. Arozal W, etal., Toxicology. 2010 Sep 29.
6. Expression of endothelin 1 and endothelin A receptor in ovarian carcinoma: evidence for an autocrine role in tumor growth. Bagnato A, etal., Cancer Res. 1999 Feb 1;59(3):720-7.
7. Endothelin-1 gene and endothelial nitric oxide synthase gene polymorphisms in adolescents with juvenile and obesity-associated hypertension. Barath A, etal., Acta Physiol Hung. 2007 Mar;94(1-2):49-66.
8. Association between the endothelin-1 gene Lys198Asn polymorphism blood pressure and plasma endothelin-1 levels in normal and pre-eclamptic pregnancy. Barden AE, etal., J Hypertens. 2001 Oct;19(10):1775-82.
9. Endothelin levels increase in rat focal and global ischemia. Barone FC, etal., J Cereb Blood Flow Metab. 1994 Mar;14(2):337-42.
10. Major role for hypoxia inducible factor-1 and the endothelin system in promoting myocardial infarction and hypertension in an animal model of obstructive sleep apnea. Belaidi E, etal., J Am Coll Cardiol. 2009 Apr 14;53(15):1309-17.
11. Circulating levels of vasoactive peptides in patients with acute bacterial meningitis. Berg RM, etal., Intensive Care Med. 2009 Sep;35(9):1604-8. Epub 2009 Jun 10.
12. Prior SO2 exposure promotes airway inflammation and subepithelial fibrosis following repeated ovalbumin challenge. Cai C, etal., Clin Exp Allergy. 2008 Oct;38(10):1680-7. Epub 2008 Jun 23.
13. Acute effects of endothelin receptor antagonists on hepatic hemodynamics of cirrhotic and noncirrhotic rats. Cavasin MA, etal., Can J Physiol Pharmacol. 2010 Jun;88(6):636-43.
14. Endothelin-1 plasma levels and vascular endothelial dysfunction in primary open angle glaucoma. Cellini M, etal., Life Sci. 2012 Oct 15;91(13-14):699-702. doi: 10.1016/j.lfs.2012.02.013. Epub 2012 Mar 3.
15. Sputum endothelin-1 is increased in cystic fibrosis and chronic obstructive pulmonary disease. Chalmers GW, etal., Eur Respir J. 1999 Jun;13(6):1288-92.
16. Association between plasma endothelin-1 and severity of different types of glaucoma. Chen HY, etal., J Glaucoma. 2013 Feb;22(2):117-22. doi: 10.1097/IJG.0b013e31822e8c65.
17. Oxidative stress-induced, poly(ADP-ribose) polymerase-dependent upregulation of ET-1 expression in chronic diabetic complications. Chiu J, etal., Can J Physiol Pharmacol. 2008 Jun;86(6):365-72.
18. Endothelin activation of reactive oxygen species mediates stress-induced pressor response in Dahl salt-sensitive prehypertensive rats. D'Angelo G, etal., Hypertension. 2010 Aug;56(2):282-9. Epub 2010 Jun 14.
19. Endothelin-1 gene variant Lys198Asn and plasma endothelin level in obstructive sleep apnea. Diefenbach K, etal., Cardiology. 2009;112(1):62-8. Epub 2008 Jun 26.
20. Bosentan, an endothelin receptor antagonist, ameliorates collagen-induced arthritis: the role of TNF-alpha in the induction of endothelin system genes. Donate PB, etal., Inflamm Res. 2012 Apr;61(4):337-48. doi: 10.1007/s00011-011-0415-5. Epub 2012 Jan 17.
21. Blood pressure-independent effect of angiotensin AT1 receptor blockade on renal endothelin-1 production in hypertensive uremic rats. Dumont Y, etal., J Hypertens. 2001 Aug;19(8):1479-87.
22. Effect of a specific endothelin receptor A antagonist and an angiotensin-converting enzyme inhibitor on glomerular mRNA levels for extracellular matrix components, metalloproteinases (MMP) and a tissue inhibitor of MMP in aminonucleoside nephrosis. Ebihara I, etal., Nephrol Dial Transplant. 1997 May;12(5):1001-6.
23. Strontium fructose 1,6-diphosphate rescues adenine-induced male hypogonadism and upregulates the testicular endothelin-1 system. Feng Y, etal., Clin Exp Pharmacol Physiol. 2007 Nov;34(11):1131-7.
24. Co-expression of endothelin-1 and endothelin-converting enzyme-1 in patients with chronic rhinitis. Furukawa K, etal., Am J Respir Cell Mol Biol. 1996 Mar;14(3):248-53.
25. Endotoxin treatment causes an upregulation of the endothelin system in the liver: amelioration of increased portal resistance by endothelin receptor antagonism. Gandhi CR, etal., J Gastroenterol Hepatol. 2001 Jan;16(1):61-9.
26. Long Non-coding RNA MALAT1/microRNA-143/VEGFA Signal Axis Modulates Vascular Endothelial Injury-Induced Intracranial Aneurysm. Gao G, etal., Nanoscale Res Lett. 2020 Jun 29;15(1):139. doi: 10.1186/s11671-020-03357-2.
27. Expression of endothelin-1 in lungs of patients with cryptogenic fibrosing alveolitis. Giaid A, etal., Lancet. 1993 Jun 19;341(8860):1550-4.
28. Abnormally increased endothelin-1 in plasma during the night in obstructive sleep apnea: relation to blood pressure and severity of disease. Gjorup PH, etal., Am J Hypertens. 2007 Jan;20(1):44-52.
29. Increased MAPK Activation and Impaired Insulin Signaling in Subcutaneous Microvascular Endothelial Cells in Type 2 Diabetes-role of endothelin-1. Gogg S, etal., Diabetes. 2009 Jul 6.
30. Gene expression of ANP, BNP and ET-1 in the heart of rats during pulmonary embolism. Gutte H, etal., PLoS One. 2010 Jun 14;5(6):e11111.
31. Increased sensitivity to acute and persistent pain in neuron-specific endothelin-1 knockout mice. Hasue F, etal., Neuroscience. 2005;130(2):349-58.
32. Normoalbuminuric type 1 diabetic patients with retinopathy have an impaired tubular response to desmopressin: its relationship with plasma endothelin-1. Hernandez C, etal., J Clin Endocrinol Metab. 2009 Jun;94(6):2060-5. Epub 2009 Mar 17.
33. Fine mapping and single nucleotide polymorphism association results of candidate genes for asthma and related phenotypes. Immervoll T, etal., Hum Mutat. 2001 Oct;18(4):327-36.
34. Aqueous humor endothelin-1 (Et-1), vascular endothelial growth factor (VEGF) and cyclooxygenase-2 (COX-2) levels in Mexican glaucomatous patients. Iwabe S, etal., Curr Eye Res. 2010 Apr;35(4):287-94. doi: 10.3109/02713680903545315.
35. Intracellular signaling pathways for norepinephrine- and endothelin-1-mediated regulation of myocardial cell apoptosis. Iwai-Kanai E and Hasegawa K, Mol Cell Biochem. 2004 Apr;259(1-2):163-8.
36. Myocardial expression of endothelin-2 is altered reciprocally to that of endothelin-1 during ischemia of cardiomyocytes in vitro and during heart failure in vivo. Kakinuma Y, etal., Life Sci. 1999;65(16):1671-83.
37. Role of endothelin in intermittent hypoxia-induced hypertension. Kanagy NL, etal., Hypertension. 2001 Feb;37(2 Part 2):511-5.
38. Decline in FEV1 related to genetic polymorphisms (+138insA/delA and Lys198Asn) of the endothelin-1 gene in COPD. A pilot study. Kaparianos A, etal., Eur Rev Med Pharmacol Sci. 2010 Aug;14(8):705-19.
39. Hypertension induced by the tyrosine kinase inhibitor sunitinib is associated with increased circulating endothelin-1 levels. Kappers MH, etal., Hypertension. 2010 Oct;56(4):675-81. Epub 2010 Aug 23.
40. Peripheral mechanisms of erectile dysfunction in a rat model of chronic cocaine use. Kendirci M, etal., Eur Urol. 2007 Aug;52(2):555-63. Epub 2007 Mar 20.
41. C-terminal pro-endothelin-1 offers additional prognostic information in patients after acute myocardial infarction: Leicester Acute Myocardial Infarction Peptide (LAMP) Study. Khan SQ, etal., Am Heart J. 2007 Oct;154(4):736-42.
42. Low blood pressure in endothelial cell-specific endothelin 1 knockout mice. Kisanuki YY, etal., Hypertension. 2010 Jul;56(1):121-8. Epub 2010 Jun 1.
43. Effects of cilnidipine on nitric oxide and endothelin-1 expression and extracellular signal-regulated kinase in hypertensive rats. Kobayashi N, etal., Eur J Pharmacol. 2001 Jun 22;422(1-3):149-57.
44. Expression of endothelin-1, ETA and ETB receptors, and ECE and distribution of endothelin-1 in failing rat heart. Kobayashi T, etal., Am J Physiol. 1999 Apr;276(4 Pt 2):H1197-206.
45. Endothelin-1 concentration is increased in the aqueous humour of patients with exfoliation syndrome. Koliakos GG, etal., Br J Ophthalmol. 2004 Apr;88(4):523-7.
46. Effects of combined hyperoxia and cyclooxygenase inhibition in neonatal rat lungs. Kuniyoshi KM, etal., Am J Transl Res. 2010 Jun 8;2(3):332-44.
47. Elevated blood pressure and craniofacial abnormalities in mice deficient in endothelin-1. Kurihara Y, etal., Nature 1994 Apr 21;368(6473):703-10.
48. Impaired ventilatory responses to hypoxia and hypercapnia in mutant mice deficient in endothelin-1. Kuwaki T, etal., Am J Physiol. 1996 Jun;270(6 Pt 2):R1279-86.
49. Plasma C-reactive protein and endothelin-1 level in patients with chronic obstructive pulmonary disease and pulmonary hypertension. Kwon YS, etal., J Korean Med Sci. 2010 Oct;25(10):1487-91. Epub 2010 Sep 17.
50. Endothelin-1 in acute lung injury and the adult respiratory distress syndrome. Langleben D, etal., Am Rev Respir Dis. 1993 Dec;148(6 Pt 1):1646-50.
51. Renal expression of parathyroid hormone-related protein (PTHrP) and PTH/PTHrP receptor in a rat model of tubulointerstitial damage. Largo R, etal., Kidney Int. 1999 Jan;55(1):82-90.
52. Effect of pyrrolidine dithiocarbamate on hepatic vascular stress gene expression during ischemia and reperfusion. Lee CH, etal., Eur J Pharmacol. 2008 Oct 24;595(1-3):100-7. Epub 2008 Aug 9.
53. Expression of endothelin-1 and its receptors in Cisplatin-induced acute renal failure in mice. Lee S and Ahn D, Korean J Physiol Pharmacol. 2008 Aug;12(4):149-53. Epub 2008 Aug 31.
54. Effects of pravastatin on functional capacity in patients with chronic obstructive pulmonary disease and pulmonary hypertension. Lee TM, etal., Clin Sci (Lond). 2009 Mar;116(6):497-505.
55. EDN1 Lys198Asn is associated with diabetic retinopathy in type 2 diabetes. Li H, etal., Mol Vis. 2008 Sep 15;14:1698-704.
56. [Inhibition of mesangial cell proliferation and mesangial matrix expansion by antisense oligodeoxynucleotide targeting preproendothelin-1 mRNA in vivo]. Li M, etal., Zhonghua Yi Xue Za Zhi. 1999 Feb;79(2):133-5.
57. The role of endothelin-1 and the endothelin B receptor in the pathogenesis of hepatopulmonary syndrome in the rat. Ling Y, etal., Hepatology. 2004 Jun;39(6):1593-602.
58. Carvedilol and lacidipine prevent cardiac hypertrophy and endothelin-1 gene overexpression after aortic banding. Massart PE, etal., Hypertension. 1999 Dec;34(6):1197-201.
59. Involvement of NO and MEK/ERK pathway in enhancement of endothelin-1-induced mesenteric artery contraction in later-stage type 2 diabetic Goto-Kakizaki rat. Matsumoto T, etal., Am J Physiol Heart Circ Physiol. 2009 May;296(5):H1388-97. Epub 2009 Mar 13.
60. Regulation of endothelin-1 by angiopoietin-1: implications for inflammation. McCarter SD, etal., Exp Biol Med (Maywood). 2006 Jun;231(6):985-91.
61. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
62. MGDs mouse GO annotations MGD data from the GO Consortium
63. MGD IEA MGD IEA
64. Progressive retinal degeneration in transgenic mice with overexpression of endothelin-1 in vascular endothelial cells. Mi XS, etal., Invest Ophthalmol Vis Sci. 2012 Jul 20;53(8):4842-51. doi: 10.1167/iovs.12-9999.
65. Glucose intolerance caused by a defect in the entero-insular axis: a study in gastric inhibitory polypeptide receptor knockout mice. Miyawaki K, etal., Proc Natl Acad Sci U S A 1999 Dec 21;96(26):14843-7.
66. Inhibitory effects of PPAR-gamma on endothelin-1-induced inflammatory pathways in vascular smooth muscle cells from normotensive and hypertensive rats. Montezano AC, etal., J Am Soc Hypertens. 2007 Mar-Apr;1(2):150-60.
67. Plasma endothelin-1 levels, pulmonary hypertension, and lung fibrosis in patients with systemic sclerosis. Morelli S, etal., Am J Med. 1995 Sep;99(3):255-60.
68. Endogenous plasma endothelin concentrations and coronary circulation in patients with mild dilated cardiomyopathy. Mundhenke M, etal., Heart. 1999 Mar;81(3):278-84.
69. Effects of unoprostone on phosphorylated extracellular signal-regulated kinase expression in endothelin-1-induced retinal and optic nerve damage. Munemasa Y, etal., Vis Neurosci. 2008 Mar-Apr;25(2):197-208. doi: 10.1017/S095252380808053X.
70. Anti-inflammatory and anti-atherogenic effects of cathechin, caffeic acid and trans-resveratrol in apolipoprotein E deficient mice. Norata GD, etal., Atherosclerosis. 2007 Apr;191(2):265-71. Epub 2006 Jun 27.
71. Endothelin-1 (ET-1) is increased in rat retina after crushing optic nerve. Oku H, etal., Curr Eye Res. 2008 Jul;33(7):611-20.
72. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
73. Expression and cellular localisation of renal endothelin-1 and endothelin receptor subtypes in autosomal-dominant polycystic kidney disease. Ong AC, etal., Nephron Exp Nephrol. 2003;93(2):e80.
74. Renal endothelin gene expression is increased in remnant kidney and correlates with disease progression. Orisio S, etal., Kidney Int. 1993 Feb;43(2):354-8.
75. The dissociation between upregulated endothelins and hemodynamic responses during polymicrobial sepsis. Ornan DA, etal., Biochim Biophys Acta. 2000 Jun 15;1501(2-3):211-8.
76. Endothelium-restricted endothelin-1 overexpression in type 1 diabetes worsens atherosclerosis and immune cell infiltration via NOX1. Ouerd S, etal., Cardiovasc Res. 2021 Mar 21;117(4):1144-1153. doi: 10.1093/cvr/cvaa168.
77. Extraocular blood flow and endothelin-1 plasma levels in patients with multiple sclerosis. Pache M, etal., Eur Neurol. 2003;49(3):164-8.
78. Increased endothelin-1 in bleomycin-induced pulmonary fibrosis and the effect of an endothelin receptor antagonist. Park SH, etal., Am J Respir Crit Care Med. 1997 Aug;156(2 Pt 1):600-8.
79. Hydrochloric acid aspiration increases right ventricular systolic pressure in rats. Pawlik MT, etal., Eur J Anaesthesiol. 2009 Apr;26(4):285-92.
80. Elevated plasma endothelin-1 levels in coronary sinus during rapid right atrial pacing in patients with slow coronary flow. Pekdemir H, etal., Int J Cardiol. 2004 Oct;97(1):35-41.
81. Plasma cytokines and portopulmonary hypertension in patients with cirrhosis waiting for orthotopic liver transplantation. Pellicelli AM, etal., Angiology. 2010 Nov;61(8):802-6. Epub 2010 May 24.
82. Impact of endothelin-1 Lys198Asn polymorphism on coronary artery disease and endorgan damage in hypertensives. Popov AF, etal., Coron Artery Dis. 2008 Nov;19(7):429-34. doi: 10.1097/MCA.0b013e32830936e5.
83. A novel endothelin receptor antagonist CPU0213 improves diabetic cardiac insufficiency attributed to up-regulation of the expression of FKBP12.6, SERCA2a, and PLB in rats. Qi MY, etal., J Cardiovasc Pharmacol. 2006 Jun;47(6):729-35.
84. Total triterpene acids, active ingredients from Fructus Corni, attenuate diabetic cardiomyopathy by normalizing ET pathway and expression of FKBP12.6 and SERCA2a in streptozotocin-rats. Qi MY, etal., J Pharm Pharmacol. 2008 Dec;60(12):1687-94.
85. Mouse MP Annotation Import Pipeline RGD automated import pipeline
86. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
87. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
88. Retinal detachment and proliferative vitreoretinopathy: central retinal artery blood velocities, intraocular pressure, and endothelin 1. Roldan-Pallares M, etal., Retina. 2013 Sep;33(8):1528-39. doi: 10.1097/IAE.0b013e318285cbef.
89. Quinapril decreases renal endothelin-1 expression and synthesis in a normotensive model of immune-complex nephritis. Ruiz-Ortega M, etal., J Am Soc Nephrol. 1997 May;8(5):756-68.
90. Prohormones for prediction of adverse medical outcome in community-acquired pneumonia and lower respiratory tract infections. Schuetz P, etal., Crit Care. 2010;14(3):R106. Epub 2010 Jun 8.
91. The cardiac endothelin system in established pressure overload left ventricular hypertrophy. Schunkert H, etal., J Mol Med (Berl). 1999 Aug;77(8):623-30.
92. Release of endothelin in the oleic acid-induced respiratory distress syndrome in rats. Simmet T, etal., Eur J Pharmacol. 1992 Feb 18;211(3):319-22.
93. Pulmonary release and coronary and peripheral consumption of big endothelin and endothelin-1 in severe heart failure: acute effects of vasodilator therapy. Stangl K, etal., Circulation. 2000 Sep 5;102(10):1132-8.
94. Identification of two nuclear factor of activated T-cells (NFAT)-response elements in the 5'-upstream regulatory region of the ET-1 promoter. Strait KA, etal., J Biol Chem. 2010 Sep 10;285(37):28520-8. Epub 2010 Jul 20.
95. Plasma endothelin-1 and thrombomodulin levels in coronary sinus during right atrial pacing and percutaneous transluminal coronary angioplasty. Suzuki H, etal., Int J Cardiol. 2000 Jun 12;74(1):15-23.
96. Elevated plasma endothelin in patients with diabetes mellitus. Takahashi K, etal., Diabetologia. 1990 May;33(5):306-10.
97. Pulmonary disease models induced by in vivo hemagglutinating virus of Japan liposome-mediated endothelin-1 gene transfer. Takeda S, etal., J Cardiovasc Pharmacol. 1998;31 Suppl 1:S336-8.
98. BMPR2 mutation alters the lung macrophage endothelin-1 cascade in a mouse model and patients with heritable pulmonary artery hypertension. Talati M, etal., Am J Physiol Lung Cell Mol Physiol. 2010 Sep;299(3):L363-73. Epub 2010 Jun 18.
99. Role of endogenous endothelin-1 in post-ischemic cardiac dysfunction and norepinephrine overflow in rat hearts. Tawa M, etal., Eur J Pharmacol. 2008 Sep 4;591(1-3):182-8. Epub 2008 Jun 14.
100. Tissue-specific modulation of endothelin receptors in a rat model of hypertension. Telemaque-Potts S, etal., J Cardiovasc Pharmacol. 2000 Nov;36(5 Suppl 1):S122-3.
101. Vascular endothelin-1 gene expression and synthesis and effect on renal type I collagen synthesis and nephroangiosclerosis during nitric oxide synthase inhibition in rats. Tharaux PL, etal., Circulation. 1999 Apr 27;99(16):2185-91.
102. [Renoprotective effects of nonselective endothelin receptor antagonist bosentan on rats with interstitial fibrosis following unilateral ureteral obstruction]. Tian XF, etal., Zhonghua Yi Xue Za Zhi. 2003 Mar 25;83(6):510-4.
103. The role of endothelin-1 and nitric oxide in the pathogenesis of hypertension in diabetic patients. Tomic M, etal., Coll Antropol. 2008 Mar;32(1):93-8.
104. Endothelin-1 and endothelin receptors in light-induced retinal degeneration. Torbidoni V, etal., Exp Eye Res. 2005 Sep;81(3):265-75.
105. Relationship between transcardiac gradient of endothelin-1 and left ventricular remodelling in patients with first anterior myocardial infarction. Tsutamoto T, etal., Eur Heart J. 2003 Feb;24(4):346-55.
106. Endothelin-1 gene polymorphism and hearing impairment in elderly Japanese. Uchida Y, etal., Laryngoscope. 2009 May;119(5):938-43. doi: 10.1002/lary.20181.
107. Plasma endothelin-1 levels in Behcet's disease. Uslu T, etal., Clin Rheumatol. 1997 Jan;16(1):59-61.
108. Despite similar reduction of blood pressure and renal ANG II and ET-1 levels aliskiren but not losartan normalizes albuminuria in hypertensive Ren-2 rats. Vanourkova Z, etal., Physiol Res. 2010;59(3):339-45.
109. Endothelin-1 plasma concentrations in patients with retinitis pigmentosa. Vingolo EM, etal., Regul Pept. 2010 Feb 25;160(1-3):64-7. doi: 10.1016/j.regpep.2009.12.006. Epub 2009 Dec 11.
110. Big endothelin-1 as a predictor of atrial fibrillation recurrence after primary ablation only in patients with paroxysmal atrial fibrillation. Wang H, etal., Herz. 2012 Dec;37(8):919-25. doi: 10.1007/s00059-012-3626-9. Epub 2012 Jun 6.
111. Endothelin in human congestive heart failure. Wei CM, etal., Circulation. 1994 Apr;89(4):1580-6.
112. Adrenomedullin and adrenomedullin binding protein-1 prevent metabolic acidosis after uncontrolled hemorrhage in rats. Wu R, etal., Crit Care Med. 2007 Mar;35(3):912-8.
113. Glucose-induced endothelin-1 expression is regulated by ERK5 in the endothelial cells and retina of diabetic rats. Wu Y, etal., Can J Physiol Pharmacol. 2010 Jun;88(6):607-15. doi: 10.1139/Y10-033.
114. PARP activation and the alteration of vasoactive factors and extracellular matrix protein in retina and kidney in diabetes. Xu B, etal., Diabetes Metab Res Rev. 2008 Jul-Aug;24(5):404-12.
115. Rescue Treatment with a Rho-Kinase Inhibitor Normalizes Right-Ventricular Function and Reverses Remodeling in Juvenile Rats with Chronic Pulmonary Hypertension. Xu EZ, etal., Am J Physiol Heart Circ Physiol. 2010 Oct 1.
116. Ex vivo blockade of endothelin-1 inhibits graft coronary artery disease in a rodent cardiac allograft model. Yamaguchi A, etal., J Heart Lung Transplant. 2002 Apr;21(4):417-24.
117. A causal role for endothelin-1 in the pathogenesis of osteoblastic bone metastases. Yin JJ, etal., Proc Natl Acad Sci U S A 2003 Sep 16;100(19):10954-9. Epub 2003 Aug 26.
118. Endothelin-1 and endothelin B type receptor are induced in mesangial proliferative nephritis in the rat. Yoshimura A, etal., Kidney Int. 1995 Oct;48(4):1290-7.
119. Endothelin-1 levels and albuminuria in patients with type 2 diabetes mellitus. Zanatta CM, etal., Diabetes Res Clin Pract. 2008 May;80(2):299-304. Epub 2008 Mar 17.
120. IL-33/ST2 signalling contributes to carrageenin-induced innate inflammation and inflammatory pain: role of cytokines, endothelin-1 and prostaglandin E2. Zarpelon AC, etal., Br J Pharmacol. 2013 May;169(1):90-101. doi: 10.1111/bph.12110.
121. Increased tissue endothelin immunoreactivity in atherosclerotic lesions associated with acute coronary syndromes. Zeiher AM, etal., Lancet. 1994 Nov 19;344(8934):1405-6.
122. [Effect and mechanism of salvianolic acid B in attenuating elevated portal pressure in a rat model of portal hypertension induced by endothelin-1]. Zhou Y, etal., Zhong Xi Yi Jie He Xue Bao. 2007 Jan;5(1):61-4.
123. Anti-IgE Therapy with Omalizumab Decreases Endothelin-1 in Exhaled Breath Condensate of Patients with Severe Persistent Allergic Asthma. Zietkowski Z, etal., Respiration. 2010 Jun 26.
124. Plasma endothelin-1 in patients with stable or unstable angina. Zuk-Popiolek I, etal., Kardiol Pol. 2003 Jun;58(6):429-37; discussion 436-7.
Additional References at PubMed
PMID:2542249   PMID:2768235   PMID:3631552   PMID:7615798   PMID:7883980   PMID:7904485   PMID:8002984   PMID:8010105   PMID:8238383   PMID:8563573   PMID:8575440   PMID:8587354  
PMID:8680799   PMID:8688455   PMID:8824799   PMID:8978712   PMID:9012511   PMID:9153073   PMID:9405477   PMID:9449664   PMID:9476873   PMID:9495516   PMID:9649553   PMID:9671575  
PMID:9767170   PMID:9826706   PMID:9834185   PMID:10194519   PMID:10221345   PMID:10349636   PMID:10354604   PMID:10405217   PMID:10479458   PMID:10512195   PMID:10570734   PMID:10597135  
PMID:10601039   PMID:10601144   PMID:10626068   PMID:10708518   PMID:10938240   PMID:10976045   PMID:11042159   PMID:11076861   PMID:11180952   PMID:11217851   PMID:11259380   PMID:11409899  
PMID:11413164   PMID:11546805   PMID:12193061   PMID:12193078   PMID:12193100   PMID:12372435   PMID:12397601   PMID:12413905   PMID:12441350   PMID:12466851   PMID:12477932   PMID:12648486  
PMID:12773307   PMID:12907686   PMID:12943527   PMID:12950721   PMID:14623826   PMID:14651962   PMID:14764893   PMID:14966371   PMID:14969349   PMID:14976138   PMID:15067320   PMID:15110048  
PMID:15115660   PMID:15126361   PMID:15239958   PMID:15314687   PMID:15327783   PMID:15489334   PMID:15543132   PMID:15567344   PMID:15610731   PMID:15632412   PMID:15645445   PMID:15784596  
PMID:15838304   PMID:15838353   PMID:15882861   PMID:15928212   PMID:16009335   PMID:16109395   PMID:16113066   PMID:16141072   PMID:16141073   PMID:16223696   PMID:16384872   PMID:16602821  
PMID:16682005   PMID:16831983   PMID:16868309   PMID:16908774   PMID:16936258   PMID:17141159   PMID:17188849   PMID:17194443   PMID:17194566   PMID:17194742   PMID:17210638   PMID:17413856  
PMID:17448648   PMID:17569879   PMID:17660396   PMID:17825250   PMID:17872466   PMID:17877911   PMID:17913832   PMID:18046543   PMID:18065659   PMID:18070924   PMID:18154738   PMID:18199583  
PMID:18212270   PMID:18310504   PMID:18391099   PMID:18391571   PMID:18401410   PMID:18475147   PMID:18515326   PMID:18516095   PMID:18516098   PMID:18524861   PMID:18621079   PMID:18635823  
PMID:18756537   PMID:18772340   PMID:19017795   PMID:19033447   PMID:19049669   PMID:19074677   PMID:19106220   PMID:19111534   PMID:19111553   PMID:19150882   PMID:19162127   PMID:19164391  
PMID:19179430   PMID:19193724   PMID:19202458   PMID:19230825   PMID:19370413   PMID:19520754   PMID:19707218   PMID:19969036   PMID:20042899   PMID:20195637   PMID:20234380   PMID:20333701  
PMID:20495147   PMID:20497976   PMID:20534536   PMID:20552721   PMID:20628430   PMID:20802183   PMID:20929948   PMID:20970401   PMID:21051538   PMID:21062919   PMID:21183790   PMID:21193583  
PMID:21237142   PMID:21267068   PMID:21448844   PMID:21482739   PMID:21525433   PMID:21677750   PMID:21705674   PMID:21801589   PMID:21873635   PMID:21918182   PMID:21926268   PMID:22053184  
PMID:22209709   PMID:22209790   PMID:22287612   PMID:22309289   PMID:22320712   PMID:22326502   PMID:22354888   PMID:22357920   PMID:22365964   PMID:22483687   PMID:22525377   PMID:22546226  
PMID:22569256   PMID:22570335   PMID:22689747   PMID:22820168   PMID:22846580   PMID:22902530   PMID:22937132   PMID:23077601   PMID:23078398   PMID:23112163   PMID:23279852   PMID:23293787  
PMID:23313614   PMID:23389444   PMID:23462468   PMID:23596057   PMID:23670300   PMID:23676500   PMID:23698114   PMID:23933587   PMID:24117726   PMID:24129228   PMID:24261709   PMID:24355292  
PMID:24371298   PMID:24412382   PMID:24412386   PMID:24412387   PMID:24424064   PMID:24491691   PMID:24507193   PMID:24523936   PMID:24530289   PMID:24586188   PMID:24632479   PMID:24632840  
PMID:24700498   PMID:24722437   PMID:24853267   PMID:24875861   PMID:24927936   PMID:25010841   PMID:25012164   PMID:25181417   PMID:25190801   PMID:25197047   PMID:25267836   PMID:25399435  
PMID:25572710   PMID:25584774   PMID:25587122   PMID:25725491   PMID:25753689   PMID:25848038   PMID:25889273   PMID:25899174   PMID:25903653   PMID:26098770   PMID:26104290   PMID:26268928  
PMID:26275708   PMID:26342031   PMID:26378152   PMID:26400543   PMID:26416771   PMID:26417040   PMID:26506449   PMID:26531127   PMID:26546722   PMID:26743624   PMID:26775567   PMID:26883974  
PMID:27026367   PMID:27031954   PMID:27062279   PMID:27102411   PMID:27280426   PMID:27381259   PMID:27465439   PMID:27553900   PMID:27612006   PMID:27694478   PMID:27832660   PMID:27870582  
PMID:27899487   PMID:28025386   PMID:28030574   PMID:28120456   PMID:28164238   PMID:28234994   PMID:28455376   PMID:28515175   PMID:28539637   PMID:28769044   PMID:29031500   PMID:29089036  
PMID:29101349   PMID:29251627   PMID:29438518   PMID:29453306   PMID:29745253   PMID:29870994   PMID:29996135   PMID:30735130   PMID:30737857   PMID:30926169   PMID:30990108   PMID:31025223  
PMID:31112136   PMID:31219639   PMID:31228092   PMID:31272714   PMID:31273050   PMID:31402170   PMID:31657718   PMID:31733648   PMID:31752395   PMID:31843983   PMID:31923844   PMID:32200679  
PMID:32358570   PMID:32437627   PMID:32572011   PMID:32755450   PMID:32946788   PMID:33443158   PMID:33649479   PMID:34893605   PMID:35466825   PMID:35477522   PMID:36637912   PMID:37088122  
PMID:37167782   PMID:37555328   PMID:37598152   PMID:37659679   PMID:38404688   PMID:38690712   PMID:38804865   PMID:39136472   PMID:39556044   PMID:39707586  


Genomics

Comparative Map Data
Edn1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391342,454,952 - 42,461,466 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1342,454,952 - 42,461,466 (+)EnsemblGRCm39 Ensembl
GRCm381342,301,476 - 42,307,990 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1342,301,476 - 42,307,990 (+)EnsemblGRCm38mm10GRCm38
MGSCv371342,396,639 - 42,403,358 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361342,312,448 - 42,318,962 (+)NCBIMGSCv36mm8
Celera1343,379,939 - 43,386,658 (+)NCBICelera
Cytogenetic Map13A4NCBI
cM Map1320.82NCBI
EDN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38612,230,516 - 12,297,194 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl612,290,361 - 12,297,194 (+)EnsemblGRCh38hg38GRCh38
GRCh37612,230,749 - 12,297,427 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36612,398,515 - 12,405,413 (+)NCBINCBI36Build 36hg18NCBI36
Build 34612,398,644 - 12,404,761NCBI
Celera613,518,582 - 13,525,484 (+)NCBICelera
Cytogenetic Map6p24.1NCBI
HuRef612,222,160 - 12,229,052 (+)NCBIHuRef
CHM1_1612,292,671 - 12,299,570 (+)NCBICHM1_1
T2T-CHM13v2.0612,098,871 - 12,165,580 (+)NCBIT2T-CHM13v2.0
Edn1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81722,660,799 - 22,666,687 (-)NCBIGRCr8
GRCr8 Ensembl1722,660,799 - 22,666,687 (-)EnsemblGRCr8 Ensembl
mRatBN7.21722,454,924 - 22,460,812 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1722,454,420 - 22,460,885 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1722,330,779 - 22,336,694 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01723,934,458 - 23,940,375 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01722,266,095 - 22,271,993 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01722,136,814 - 22,143,745 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1722,137,324 - 22,143,324 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01724,117,499 - 24,124,188 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41728,303,886 - 28,309,775 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1722,134,975 - 22,140,901 (-)NCBICelera
RGSC_v3.11728,306,726 - 28,312,616 (-)NCBI
Cytogenetic Map17p12NCBI
Edn1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554652,287,798 - 2,314,753 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554652,287,906 - 2,314,945 (-)NCBIChiLan1.0ChiLan1.0
EDN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2526,853,626 - 26,951,878 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1622,843,513 - 22,941,706 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0612,076,312 - 12,142,861 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1612,405,538 - 12,503,545 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl612,462,718 - 12,503,545 (+)Ensemblpanpan1.1panPan2
EDN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13511,808,892 - 11,815,383 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3511,808,892 - 11,815,383 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3511,760,401 - 11,766,891 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03511,907,692 - 11,914,182 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3511,907,494 - 11,914,179 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13511,736,723 - 11,743,212 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03511,786,346 - 11,792,841 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03513,110,983 - 13,117,475 (+)NCBIUU_Cfam_GSD_1.0
Edn1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494612,616,525 - 12,623,475 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936534885,287 - 891,772 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936534885,489 - 892,292 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EDN1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl78,751,695 - 8,758,348 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.178,752,018 - 8,758,354 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.279,120,519 - 9,159,252 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap7p1.3-p1.2NCBI
EDN1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11759,854,186 - 59,861,319 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1759,853,699 - 59,861,198 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604412,341,006 - 12,348,096 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Edn1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475613,842,164 - 13,849,029 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475613,842,482 - 13,849,003 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Edn1
266 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:424
Count of miRNA genes:295
Interacting mature miRNAs:342
Transcripts:ENSMUST00000021796
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300561Heal7_mwound healing/regeneration 7 (mouse)Not determined133614482070144904Mouse
1357591Tesq1_mtestis weight QTL 1 (mouse)Not determined132061551255720517Mouse
1301015Sysbp2_msystolic blood pressure 2 (mouse)Not determined132047761259821605Mouse
12738439Twq4_mtestis weight QTL 4 (mouse)133112911065129110Mouse
4142009Pregq3_mpregnancy QTL 3 (mouse)Not determined132061551272385189Mouse
1357587Pfat3_mpredicted fat percentage 3 (mouse)Not determined133610153070101640Mouse
10401111Pgia40_mproteoglycan induced arthritis 40 (mouse)Not determined132791846961918560Mouse
10412235Scgq5_mspontaneous crescentic glomerulonephritis QTL 5 (mouse)Not determined133606090896239162Mouse
10755517Chol15_mcholesterol 15 (mouse)133096946764969467Mouse
15039353Nmrs35_mNAFLD-associated magnetic resonance shift 35 (mouse)134058825374588253Mouse
1302157Bwem2_mbody weight day 30 males 2 (mouse)Not determined133962924973629397Mouse
10402494Igmsc1_mimmunoglobulin M secreting cells 1 (mouse)Not determined131716854544918560Mouse
13463469Gssq1_mglomerulosclerosis severity QTL 1 (mouse)131906090853061050Mouse
1301299Sluc23_msusceptibility to lung cancer 23 (mouse)Not determined133492194368922081Mouse
12880423V25Dq7_mvitamin D inactive form serum level QTL 7 (mouse)131958398353583983Mouse
1558898Hpi1_mhapatic PMN infiltration 1 (mouse)Not determined13441402553101640Mouse
4142489Ath25_matherosclerosis 25 (mouse)Not determined2583652959836529Mouse
10755533Chol18_mcholesterol 18 (mouse)133096946764969467Mouse
1300985Bmd13_mbone mineral density 13 (mouse)Not determined133962924973629397Mouse
1301880Hypt_mhypertension (mouse)Not determined131815679252156924Mouse
10045618Heal17_mwound healing/regeneration 17 (mouse)Not determined132074693954747056Mouse
10045621Heal21_mwound healing/regeneration 21 (mouse)Not determined132821737962217515Mouse
1300862Cfbw5_mcystic fibrosis body weight 5 (mouse)Not determined133872035872720517Mouse
1300668Pas10_mpulmonary adenoma susceptibility 10 (mouse)Not determined134148904275489158Mouse
26884393Humsd7_mhumerus midshaft diameter 7, 16 week (mouse)13395000076048119Mouse
1300710Pcd4ts2_mp-glycoprotein positive CD4 T cell subset 2 (mouse)Not determined132821044262210544Mouse
1301734Acsns2_mAngiostrongylus costaricensis nematode susceptibility 2 (mouse)Not determined133610153070101640Mouse
14696729Kidlq2_mkidney weight, left QTL 2 (mouse)133134473665344736Mouse
1301801Cpfd5_mcerebellum pattern fissures (mouse)Not determined133962924973629397Mouse
4142147Mvwf4_mmodifier of von Willebrand factor 4 (mouse)Not determined20477612112898424Mouse
1357802Vtbt15_mvertebral trabecular bone trait 15 (mouse)Not determined132821737962217515Mouse

Markers in Region
D43775  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381342,307,177 - 42,307,295UniSTSGRCm38
MGSCv371342,402,546 - 42,402,664UniSTSGRCm37
Celera1343,385,846 - 43,385,964UniSTS
Cytogenetic Map13A4UniSTS
cM Map1326.0UniSTS
Whitehead/MRC_RH13445.44UniSTS
Edn1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv371342,403,080 - 42,403,247UniSTSGRCm37
Celera1343,386,380 - 43,386,547UniSTS
Cytogenetic Map13A4UniSTS
cM Map1326.0UniSTS
cM Map1326.0UniSTS
cM Map1326.0UniSTS
U35233  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381342,307,045 - 42,307,205UniSTSGRCm38
MGSCv371342,402,414 - 42,402,574UniSTSGRCm37
Celera1343,385,714 - 43,385,874UniSTS
Cytogenetic Map13A4UniSTS
cM Map1326.0UniSTS
Whitehead_YAC13 UniSTS
D13Mit138  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381342,300,805 - 42,300,948UniSTSGRCm38
MGSCv371342,396,174 - 42,396,317UniSTSGRCm37
Celera1343,379,474 - 43,379,617UniSTS
Cytogenetic Map13A4UniSTS
cM Map1324.0UniSTS
Whitehead Genetic1314.2UniSTS
Whitehead_YAC13 UniSTS
Edn1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map13A4UniSTS
Edn1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381342,307,711 - 42,307,878UniSTSGRCm38
MGSCv371342,403,080 - 42,403,247UniSTSGRCm37
Celera1343,386,380 - 43,386,547UniSTS
Cytogenetic Map13A4UniSTS
cM Map1326.0UniSTS
Edn1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map13A4UniSTS
cM Map1326.0UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_010104 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB081657 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC154635 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK040778 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK152647 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK153437 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC029547 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY618506 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466546 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ135809 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D43775 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D70842 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU095329 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M26497 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S66650 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U07982 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U35233 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000021796   ⟹   ENSMUSP00000021796
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1342,454,952 - 42,461,466 (+)Ensembl
GRCm38.p6 Ensembl1342,301,476 - 42,307,990 (+)Ensembl
RefSeq Acc Id: NM_010104   ⟹   NP_034234
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391342,454,952 - 42,461,466 (+)NCBI
GRCm381342,301,476 - 42,307,990 (+)NCBI
MGSCv371342,396,639 - 42,403,358 (+)RGD
Celera1343,379,939 - 43,386,658 (+)RGD
cM Map13 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_034234   ⟸   NM_010104
- Peptide Label: preproprotein
- UniProtKB: P70203 (UniProtKB/Swiss-Prot),   P97338 (UniProtKB/Swiss-Prot),   P22387 (UniProtKB/Swiss-Prot),   Q544E0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000021796   ⟸   ENSMUST00000021796
Protein Domains
Endothelin-like toxin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P22387-F1-model_v2 AlphaFold P22387 1-202 view protein structure

Promoters
RGD ID:8680186
Promoter ID:EPDNEW_M18124
Type:multiple initiation site
Name:Edn1_1
Description:Mus musculus endothelin 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381342,301,619 - 42,301,679EPDNEW
RGD ID:6823832
Promoter ID:MM_KWN:13915
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Lung,   MEF_B4,   MEF_B6
Transcripts:NM_010104_EDN1,   UC007QFL.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361342,395,991 - 42,397,067 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:95283 AgrOrtholog
Ensembl Genes ENSMUSG00000021367 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000021796 ENTREZGENE
  ENSMUST00000021796.9 UniProtKB/Swiss-Prot
InterPro Endothelin UniProtKB/Swiss-Prot
  Endothelin_toxin_CS UniProtKB/Swiss-Prot
  Endothln-like_toxin UniProtKB/Swiss-Prot
KEGG Report mmu:13614 UniProtKB/Swiss-Prot
MGD MGI:95283 ENTREZGENE
NCBI Gene 13614 ENTREZGENE
PANTHER ENDOTHELIN-1 UniProtKB/Swiss-Prot
  PTHR13874 UniProtKB/Swiss-Prot
Pfam Endothelin UniProtKB/Swiss-Prot
PhenoGen Edn1 PhenoGen
PRINTS ENDOTHELIN UniProtKB/Swiss-Prot
PROSITE ENDOTHELIN UniProtKB/Swiss-Prot
SMART END UniProtKB/Swiss-Prot
UniProt EDN1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  P70203 ENTREZGENE
  P97338 ENTREZGENE
  Q544E0 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary P70203 UniProtKB/Swiss-Prot
  P97338 UniProtKB/Swiss-Prot