Dbh (dopamine beta hydroxylase) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Dbh (dopamine beta hydroxylase) Mus musculus
Analyze
Symbol: Dbh
Name: dopamine beta hydroxylase
RGD ID: 10460
MGI Page MGI
Description: Predicted to enable copper ion binding activity and dopamine beta-monooxygenase activity. Involved in catecholamine metabolic process; locomotory behavior; and positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including behavioral response to ethanol; homoiothermy; and learning or memory. Located in secretory granule lumen and secretory granule membrane. Is expressed in several structures, including adrenal gland; alimentary system; and nervous system. Used to study dopamine beta-hydroxylase deficiency. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; attention deficit hyperactivity disorder; dopamine beta-hydroxylase deficiency; hypertension; and migraine with aura. Orthologous to human DBH (dopamine beta-hydroxylase).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: dopamine beta-hydroxylase; dopamine beta-monooxygenase
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39227,055,519 - 27,073,216 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl227,055,245 - 27,073,212 (+)EnsemblGRCm39 Ensembl
GRCm38227,165,507 - 27,183,204 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl227,165,233 - 27,183,200 (+)EnsemblGRCm38mm10GRCm38
MGSCv37227,021,027 - 27,038,724 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36226,987,242 - 27,004,928 (+)NCBIMGSCv36mm8
Celera226,868,411 - 26,886,118 (+)NCBICelera
Cytogenetic Map2A3NCBI
cM Map219.29NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-adrenaline  (EXP)
(R)-noradrenaline  (EXP)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (EXP)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (EXP)
2,4-D  (ISO)
2-methylcholine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-chloro-7-iodoquinolin-8-ol  (ISO)
6-propyl-2-thiouracil  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (EXP,ISO)
aluminium hydroxide  (ISO)
amitraz  (ISO)
ammonium chloride  (ISO)
arsenous acid  (EXP)
artesunate  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bromocriptine  (ISO)
bupropion  (EXP)
C60 fullerene  (ISO)
chlorpyrifos  (ISO)
citalopram  (EXP)
cocaine  (EXP,ISO)
colforsin daropate hydrochloride  (ISO)
cyanazine  (ISO)
D-mannitol  (EXP)
desipramine  (EXP)
dexamethasone  (ISO)
diarsenic trioxide  (EXP)
diazinon  (ISO)
dibutyl phthalate  (EXP)
dichlorvos  (ISO)
dieldrin  (ISO)
disulfiram  (EXP,ISO)
dobutamine  (EXP)
dopamine  (EXP,ISO)
fluoxetine  (EXP,ISO)
folic acid  (EXP)
Fusaric acid  (ISO)
hydrogen sulfide  (EXP)
lamotrigine  (ISO)
manganese(II) chloride  (ISO)
methamphetamine  (ISO)
methimazole  (ISO)
methoxychlor  (ISO)
methyllycaconitine  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
nicotine  (ISO)
nimodipine  (ISO)
paracetamol  (ISO)
Pargyline  (EXP)
paroxetine  (EXP)
procymidone  (ISO)
reboxetine  (EXP)
reserpine  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
sarin  (ISO)
serotonin  (EXP)
sertraline  (EXP)
simazine  (ISO)
tamoxifen  (ISO)
taurine  (EXP)
testosterone  (ISO)
thimerosal  (ISO)
triazines  (EXP)
tris(2-butoxyethyl) phosphate  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal avoidance learning behavior  (IAGP)
abnormal eating behavior  (IAGP)
abnormal food intake  (IAGP)
abnormal gait  (IAGP)
abnormal glucose homeostasis  (IAGP)
abnormal habituation to a new environment  (IAGP)
abnormal heart morphology  (IAGP)
abnormal motor capabilities/coordination/movement  (IAGP)
abnormal nervous system physiology  (IAGP)
abnormal postnatal growth  (IAGP)
absent circulating adrenaline  (IAGP)
absent circulating noradrenaline  (IAGP)
adipsia  (IAGP)
akinesia  (IAGP)
aphagia  (IAGP)
blepharoptosis  (IAGP)
bradykinesia  (IAGP)
catalepsy  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased brain size  (IAGP)
decreased circulating glucagon level  (IAGP)
decreased circulating glucose level  (IAGP)
decreased compensatory feeding amount  (IAGP)
decreased dopamine level  (IAGP)
decreased food intake  (IAGP)
decreased glucagon secretion  (IAGP)
decreased locomotor activity  (IAGP)
decreased stereotypic behavior  (IAGP)
embryonic lethality during organogenesis  (IAGP)
embryonic lethality during organogenesis, incomplete penetrance  (IAGP)
hunched posture  (IAGP)
hyperactivity  (IAGP)
hyporesponsive to tactile stimuli  (IAGP)
impaired behavioral response to addictive substance  (IAGP)
impaired coordination  (IAGP)
increased bone mass  (IAGP)
increased bone ossification  (IAGP)
increased circulating corticosterone level  (IAGP)
increased circulating insulin level  (IAGP)
increased coping response  (IAGP)
increased dopamine level  (IAGP)
increased food intake  (IAGP)
increased osteoblast cell number  (IAGP)
increased stereotypic behavior  (IAGP)
increased thigmotaxis  (IAGP)
insulin resistance  (IAGP)
neonatal lethality, incomplete penetrance  (IAGP)
no abnormal phenotype detected  (IAGP)
poor grooming  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality  (IAGP)
premature death  (IAGP)
prenatal lethality, complete penetrance  (IAGP)
weight loss  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Brady KP, etal., Genome Res 1997 Nov;7(11):1085-93.
2. Selective losses of brainstem catecholamine neurons after hypoxia-ischemia in the immature rat pup. Buller KM, etal., Pediatr Res. 2008 Apr;63(4):364-9.
3. Human dopamine beta-hydroxylase promoter variant alters transcription in chromaffin cells, enzyme secretion, and blood pressure. Chen Y, etal., Am J Hypertens. 2011 Jan;24(1):24-32. Epub 2010 Sep 2.
4. Down-regulation of genes related to the adrenergic system may contribute to splanchnic vasodilation in rat portal hypertension. Coll M, etal., J Hepatol. 2008 Jul;49(1):43-51. Epub 2008 Apr 18.
5. Atrophy of mesenteric sympathetic innervation may contribute to splanchnic vasodilation in rat portal hypertension. Coll M, etal., Liver Int. 2010 Apr;30(4):593-602. Epub 2009 Nov 30.
6. Association between a 19 bp deletion polymorphism at the dopamine beta-hydroxylase (DBH) locus and migraine with aura. Fernandez F, etal., J Neurol Sci. 2006 Dec 21;251(1-2):118-23. Epub 2006 Nov 7.
7. The DBH -1021 C/T polymorphism is not associated with alcoholism but possibly with patients' exposure to life events. Freire MT, etal., J Neural Transm. 2005 Sep;112(9):1269-74.
8. A functional polymorphism regulating dopamine beta-hydroxylase influences against Parkinson's disease. Healy DG, etal., Ann Neurol 2004 Mar;55(3):443-6.
9. Effects of insulin treatment without and with recurrent hypoglycemia on hypoglycemic counterregulation and adrenal catecholamine-synthesizing enzymes in diabetic rats. Inouye KE, etal., Endocrinology. 2006 Apr;147(4):1860-70. Epub 2006 Jan 5.
10. Degeneration of the locus ceruleus noradrenergic neurons in the stress-induced depression of rats. Kitayama IT, etal., Ann N Y Acad Sci. 2008 Dec;1148:95-8.
11. DBH*444G/A polymorphism of the dopamine-beta-hydroxylase gene is associated with alcoholism but not with severe alcohol withdrawal symptoms. Kohnke MD, etal., J Neural Transm. 2006 Jul;113(7):869-76. Epub 2005 Oct 27.
12. Catecholaminergic systems in stress: structural and molecular genetic approaches. Kvetnansky R, etal., Physiol Rev. 2009 Apr;89(2):535-606.
13. Dopaminergic system dysregulation in the mrsk2_KO mouse, an animal model of the Coffin-Lowry syndrome. Marques Pereira P, etal., J Neurochem. 2008 Dec;107(5):1325-34. Epub 2008 Sep 24.
14. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
15. MGDs mouse GO annotations MGD data from the GO Consortium
16. MGD IEA MGD IEA
17. Noradrenergic nuclei that receive sensory input during mating and project to the ventromedial hypothalamus play a role in mating-induced pseudopregnancy in the female rat. Northrop LE, etal., J Neuroendocrinol. 2010 Oct;22(10):1061-71. doi: 10.1111/j.1365-2826.2010.02049.x.
18. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
19. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
20. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
21. Noradrenergic neurons of the area postrema mediate amylin's hypophagic action. Potes CS, etal., Am J Physiol Regul Integr Comp Physiol. 2010 Aug;299(2):R623-31. Epub 2010 Jun 16.
22. Mouse MP Annotation Import Pipeline RGD automated import pipeline
23. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
24. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
25. Continuous antagonism of the ghrelin receptor results in early induction of salt-sensitive hypertension. Sato T, etal., J Mol Neurosci. 2011 Feb;43(2):193-9. Epub 2010 Jul 2.
26. Association of the dopamine beta hydroxylase gene with attention deficit hyperactivity disorder: genetic analysis of the Milwaukee longitudinal study. Smith KM, etal., Am J Med Genet B Neuropsychiatr Genet 2003 May 15;119(1):77-85.
27. Dbh(-/-) mice are hypotensive, have altered circadian rhythms, and have abnormal responses to dieting and stress. Swoap SJ, etal., Am J Physiol Regul Integr Comp Physiol. 2004 Jan;286(1):R108-13. Epub 2003 Sep 11.
28. Expression levels of mRNAs for catecholamine biosynthetic enzymes as markers of acute response to contusion stress during the early postmortem period. Takahashi S Tohoku J Exp Med. 2008 Nov;216(3):239-48.
29. Noradrenaline is essential for mouse fetal development. Thomas SA, etal., Nature 1995 Apr 13;374(6523):643-6.
30. Brain insulin-like growth factor and neurotrophin resistance in Parkinson's disease and dementia with Lewy bodies: potential role of manganese neurotoxicity. Tong M, etal., J Alzheimers Dis. 2009;16(3):585-99.
Additional References at PubMed
PMID:1280432   PMID:1315305   PMID:7533563   PMID:7588260   PMID:7590237   PMID:7774911   PMID:7961964   PMID:8075499   PMID:8088777   PMID:8548806   PMID:8597642   PMID:8799160  
PMID:8835533   PMID:8922421   PMID:9115735   PMID:9139828   PMID:9151744   PMID:9189272   PMID:9374403   PMID:9393852   PMID:9435281   PMID:9539123   PMID:9590288   PMID:9603211  
PMID:9829800   PMID:10027299   PMID:10051631   PMID:10230789   PMID:10336693   PMID:10338466   PMID:10349636   PMID:10360575   PMID:10482239   PMID:10518589   PMID:10594079   PMID:10777779  
PMID:10802666   PMID:10835639   PMID:10882479   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11430814   PMID:11454927   PMID:11517332   PMID:11527648   PMID:11567066   PMID:11581159  
PMID:11764279   PMID:11772881   PMID:11805341   PMID:11825874   PMID:12370425   PMID:12419242   PMID:12466851   PMID:12477932   PMID:12538862   PMID:12604788   PMID:12682014   PMID:12718440  
PMID:12736175   PMID:12810600   PMID:12901866   PMID:12959968   PMID:12960087   PMID:14513037   PMID:14645475   PMID:14681479   PMID:14684249   PMID:14960494   PMID:15066288   PMID:15148402  
PMID:15231500   PMID:15233745   PMID:15301933   PMID:15317940   PMID:15329349   PMID:15353215   PMID:15368448   PMID:15374756   PMID:15606908   PMID:15716360   PMID:15724149   PMID:15741322  
PMID:15833801   PMID:15849236   PMID:15922045   PMID:15930502   PMID:16141072   PMID:16141073   PMID:16221852   PMID:16222052   PMID:16226228   PMID:16319924   PMID:16339193   PMID:16341013  
PMID:16388913   PMID:16399693   PMID:16439213   PMID:16484499   PMID:16602821   PMID:16628617   PMID:16677628   PMID:16723393   PMID:16854392   PMID:16923149   PMID:16943277   PMID:17017126  
PMID:17099719   PMID:17156935   PMID:17220188   PMID:17376811   PMID:17478475   PMID:17507395   PMID:17531968   PMID:17687036   PMID:17702867   PMID:17975121   PMID:18003826   PMID:18042179  
PMID:18083142   PMID:18094025   PMID:18162309   PMID:18424435   PMID:18771734   PMID:19107190   PMID:19120118   PMID:19176214   PMID:19251826   PMID:19542360   PMID:19545628   PMID:19741115  
PMID:19864633   PMID:20080794   PMID:20089918   PMID:20193660   PMID:20336622   PMID:20385965   PMID:20457670   PMID:20493948   PMID:20702712   PMID:20875861   PMID:21068058   PMID:21148012  
PMID:21377513   PMID:21539825   PMID:21677750   PMID:21873635   PMID:21976502   PMID:22200605   PMID:22323706   PMID:22323723   PMID:22534286   PMID:22683331   PMID:22718343   PMID:22860215  
PMID:22883210   PMID:22911456   PMID:22922260   PMID:22992525   PMID:23042227   PMID:23209785   PMID:23486971   PMID:23555309   PMID:23591430   PMID:23648511   PMID:23684624   PMID:23852112  
PMID:23959937   PMID:23961995   PMID:24565998   PMID:24952961   PMID:25071457   PMID:25093893   PMID:25326128   PMID:25516547   PMID:25661788   PMID:25673838   PMID:25942625   PMID:26402067  
PMID:26586220   PMID:26644453   PMID:26857994   PMID:27094431   PMID:27148966   PMID:27264177   PMID:27301688   PMID:27441631   PMID:28775681   PMID:28918935   PMID:29288665   PMID:29688375  
PMID:30269865   PMID:30341172   PMID:30523254   PMID:31200001   PMID:31793911   PMID:31801063   PMID:32065256   PMID:32094113   PMID:32791039   PMID:33288908   PMID:33536201   PMID:33740425  
PMID:34081911   PMID:34585668   PMID:35086530   PMID:35103284   PMID:35263575   PMID:36889282   PMID:37102362   PMID:37857606   PMID:37993711   PMID:38016975   PMID:38025786   PMID:38058990  
PMID:38182836   PMID:38649278   PMID:38802592   PMID:38810638   PMID:38830763   PMID:38850753   PMID:38915692  


Genomics

Comparative Map Data
Dbh
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39227,055,519 - 27,073,216 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl227,055,245 - 27,073,212 (+)EnsemblGRCm39 Ensembl
GRCm38227,165,507 - 27,183,204 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl227,165,233 - 27,183,200 (+)EnsemblGRCm38mm10GRCm38
MGSCv37227,021,027 - 27,038,724 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36226,987,242 - 27,004,928 (+)NCBIMGSCv36mm8
Celera226,868,411 - 26,886,118 (+)NCBICelera
Cytogenetic Map2A3NCBI
cM Map219.29NCBI
DBH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389133,636,363 - 133,659,329 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9133,636,363 - 133,659,329 (+)EnsemblGRCh38hg38GRCh38
GRCh379136,501,485 - 136,524,451 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369135,491,306 - 135,514,287 (+)NCBINCBI36Build 36hg18NCBI36
Build 349133,531,038 - 133,554,020NCBI
Celera9107,048,360 - 107,071,346 (+)NCBICelera
Cytogenetic Map9q34.2NCBI
HuRef9106,002,148 - 106,025,141 (+)NCBIHuRef
CHM1_19136,651,448 - 136,674,425 (+)NCBICHM1_1
T2T-CHM13v2.09145,852,365 - 145,875,347 (+)NCBIT2T-CHM13v2.0
Dbh
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8330,886,313 - 30,903,313 (+)NCBIGRCr8
mRatBN7.2310,488,260 - 10,505,245 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl310,488,260 - 10,505,248 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx313,554,214 - 13,571,202 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0322,139,613 - 22,156,601 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0320,394,908 - 20,411,896 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.035,709,236 - 5,731,895 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl35,709,236 - 5,731,898 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0311,073,477 - 11,095,363 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.436,052,706 - 6,069,826 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.136,053,005 - 6,070,129 (+)NCBI
Celera35,285,082 - 5,302,054 (+)NCBICelera
Cytogenetic Map3p12NCBI
Dbh
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555132,918,286 - 2,932,247 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555132,918,085 - 2,932,481 (+)NCBIChiLan1.0ChiLan1.0
DBH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2115,692,146 - 5,715,877 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan195,694,480 - 5,717,385 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v09104,761,504 - 104,784,445 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19133,371,818 - 133,394,581 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9133,371,821 - 133,393,697 (+)Ensemblpanpan1.1panPan2
DBH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1950,004,806 - 50,024,130 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl950,004,806 - 50,024,130 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha949,285,838 - 49,305,131 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0950,879,184 - 50,898,677 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl950,879,184 - 50,898,677 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1949,640,508 - 49,659,973 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0949,982,444 - 50,001,971 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0950,060,855 - 50,080,372 (+)NCBIUU_Cfam_GSD_1.0
Dbh
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947200,048,835 - 200,073,044 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366693,301,802 - 3,320,643 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366693,302,014 - 3,326,233 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DBH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1273,204,175 - 273,225,552 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11273,204,407 - 273,225,562 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21307,178,237 - 307,199,384 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap1q2.13NCBI
DBH
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1124,474,041 - 4,498,942 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl124,474,958 - 4,498,910 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666058490,145 - 515,071 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dbh
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247602,015,474 - 2,029,939 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247602,016,066 - 2,030,240 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:392
Count of miRNA genes:320
Interacting mature miRNAs:348
Transcripts:ENSMUST00000000910, ENSMUST00000155290
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552706Cia24_mcollagen induced arthritis QTL 24 (mouse)Not determined22467911533523172Mouse
8552707Cia23_mcollagen induced arthritis QTL 23 (mouse)Not determined21212953766556453Mouse
12904005Cfq2_mconditioned fear QTL 2 (mouse)22702264256396228Mouse
1300624Insq7_minsulin QTL 7 (mouse)Not determined2938444643384575Mouse
8552705Cia25_mcollagen induced arthritis 25 (mouse)Not determined22467911533523172Mouse
39128209Lwq14_mliver weight QTL 14 (mouse)220897778118894840Mouse
1558738W6q1_mweight 6 weeks QTL 1 (mouse)Not determined220897778118894840Mouse
26884438Sklq12_mskull length QTL 12, 16 week (mouse)22459001254890012Mouse
1302174Dssc2_mdextran sodium sulfate induced colitis QTL2 (mouse)Not determined224224632148700377Mouse
1301790Pcfm1_mperiosteal circumference and femur length 1 (mouse)Not determined2823629642236396Mouse
4142130Pgis2_mproteoglycan induced spondylitis 2 (mouse)Not determined22530805156971811Mouse
1301980Fcsa5_mfemoral cross-sectional area 5 (mouse)Not determined2767911541679261Mouse
1301376Etohc1_methanol consumption 1 (mouse)Not determined22112972555129871Mouse
1558915W3q1_mweight 3 weeks QTL 1 (mouse)Not determined220897778118894840Mouse
12792980Fbmd1_mfemoral bone mineral density 1, females only (mouse)22503449245034492Mouse
1301641Sbmd2_mspinal bone mineral density 2 (mouse)Not determined21421456748214713Mouse
1301769Orgwq2_morgan weight QTL 2 (mouse)Not determined2388712693421651Mouse
1357454Kidq1_mkidney weight QTL 1 (mouse)Not determined220897778118894840Mouse
10755513Amzn4_manatomical modifier of Zfp423 4 (mouse)2938444643384575Mouse
1558966W10q9_mweight 10 weeks QTL 9 (mouse)Not determined220897778118894840Mouse
13463470Tubisq1_mtubulointerstitial injury severity, QTL 1 (mouse)22368914557689269Mouse
12904743Carcdq3_mcardiac collagen deposition QTL 3 (mouse)2323494028179150Mouse
1558899Egq1_mearly growth QTL 1 (mouse)Not determined220897778118894840Mouse
1357681Hrtq1_mheart weight QTL 1 (mouse)Not determined220897778118894840Mouse
1357436Splq1_mspleen weight QTL 1 (mouse)Not determined220897778118894840Mouse
1357881Estoq1_membryo survival total QTL 1 (mouse)Not determined220897778118894840Mouse
4141708Pbwg1.2_mpostnatal body weight growth 1.2 (mouse)Not determined2112972555129871Mouse
10043876Adip22_madiposity 22 (mouse)Not determined2830805142308240Mouse

Markers in Region
Dbh  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv37227,036,522 - 27,037,019UniSTSGRCm37
MGSCv37227,038,315 - 27,038,439UniSTSGRCm37
Celera226,883,916 - 26,884,413UniSTS
Celera226,885,709 - 26,885,833UniSTS
Cytogenetic Map2A3UniSTS
cM Map215.5UniSTS
cM Map215.5UniSTS
cM Map215.5UniSTS
cM Map215.5UniSTS
DBH  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38227,181,002 - 27,181,499UniSTSGRCm38
MGSCv37227,036,522 - 27,037,019UniSTSGRCm37
Celera226,883,916 - 26,884,413UniSTS
Cytogenetic Map2A3UniSTS
Dbh  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38227,182,795 - 27,182,919UniSTSGRCm38
MGSCv37227,038,315 - 27,038,439UniSTSGRCm37
Celera226,885,709 - 26,885,833UniSTS
Cytogenetic Map2A3UniSTS
cM Map215.5UniSTS
Dbh  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2A3UniSTS
cM Map215.5UniSTS
Dbh  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2A3UniSTS
cM Map215.5UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000000910   ⟹   ENSMUSP00000000910
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl227,055,245 - 27,073,212 (+)Ensembl
GRCm38.p6 Ensembl227,165,233 - 27,183,200 (+)Ensembl
Ensembl Acc Id: ENSMUST00000155290
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl227,067,105 - 27,067,384 (+)Ensembl
GRCm38.p6 Ensembl227,177,093 - 27,177,372 (+)Ensembl
RefSeq Acc Id: NM_138942   ⟹   NP_620392
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39227,055,519 - 27,073,216 (+)NCBI
GRCm38227,165,507 - 27,183,204 (+)ENTREZGENE
MGSCv37227,021,027 - 27,038,724 (+)RGD
Celera226,868,411 - 26,886,118 (+)RGD
cM Map2 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_620392 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB24330 (Get FASTA)   NCBI Sequence Viewer  
  AAI41023 (Get FASTA)   NCBI Sequence Viewer  
  AAI71949 (Get FASTA)   NCBI Sequence Viewer  
  BAE21055 (Get FASTA)   NCBI Sequence Viewer  
  EDL08360 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000000910
  ENSMUSP00000000910.7
GenBank Protein Q64237 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_620392   ⟸   NM_138942
- UniProtKB: Q3V1U4 (UniProtKB/Swiss-Prot),   Q64237 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000000910   ⟸   ENSMUST00000000910
Protein Domains
DOMON

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q64237-F1-model_v2 AlphaFold Q64237 1-622 view protein structure

Promoters
RGD ID:6876754
Promoter ID:EPDNEW_M1828
Type:multiple initiation site
Name:Dbh_1
Description:Mus musculus dopamine beta hydroxylase , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38227,165,507 - 27,165,567EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:94864 AgrOrtholog
Ensembl Genes ENSMUSG00000000889 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000000910 ENTREZGENE
  ENSMUST00000000910.7 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.120.230 UniProtKB/Swiss-Prot
  2.60.120.310 UniProtKB/Swiss-Prot
InterPro Cu2_ascorb_mOase-like_C UniProtKB/Swiss-Prot
  Cu2_ascorb_mOase_CS-1 UniProtKB/Swiss-Prot
  Cu2_ascorb_mOase_CS-2 UniProtKB/Swiss-Prot
  Cu2_ascorb_mOase_N UniProtKB/Swiss-Prot
  Cu2_ascorb_mOase_N_sf UniProtKB/Swiss-Prot
  Cu2_monoox_C UniProtKB/Swiss-Prot
  DBH-like UniProtKB/Swiss-Prot
  DOH_DOMON UniProtKB/Swiss-Prot
  DOMON_domain UniProtKB/Swiss-Prot
  PHM/PNGase_F_dom_sf UniProtKB/Swiss-Prot
  Tbh/DBH UniProtKB/Swiss-Prot
KEGG Report mmu:13166 UniProtKB/Swiss-Prot
MGD MGI:94864 ENTREZGENE
NCBI Gene 13166 ENTREZGENE
PANTHER DOPAMINE BETA-HYDROXYLASE UniProtKB/Swiss-Prot
  PTHR10157 UniProtKB/Swiss-Prot
Pfam Cu2_monoox_C UniProtKB/Swiss-Prot
  Cu2_monooxygen UniProtKB/Swiss-Prot
  DOMON UniProtKB/Swiss-Prot
PhenoGen Dbh PhenoGen
PRINTS DBMONOXGNASE UniProtKB/Swiss-Prot
PROSITE CU2_MONOOXYGENASE_1 UniProtKB/Swiss-Prot
  CU2_MONOOXYGENASE_2 UniProtKB/Swiss-Prot
  DOMON UniProtKB/Swiss-Prot
SMART DoH UniProtKB/Swiss-Prot
Superfamily-SCOP SSF49742 UniProtKB/Swiss-Prot
UniProt DOPO_MOUSE UniProtKB/Swiss-Prot
  Q3V1U4 ENTREZGENE
  Q64237 ENTREZGENE
UniProt Secondary Q3V1U4 UniProtKB/Swiss-Prot