Cyp1b1 (cytochrome P450, family 1, subfamily b, polypeptide 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Cyp1b1 (cytochrome P450, family 1, subfamily b, polypeptide 1) Mus musculus
Analyze
Symbol: Cyp1b1
Name: cytochrome P450, family 1, subfamily b, polypeptide 1
RGD ID: 10439
MGI Page MGI
Description: Enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen. Involved in several processes, including camera-type eye development; regulation of gene expression; and retinoid metabolic process. Acts upstream of or within several processes, including blood vessel endothelial cell migration; endothelial cell-cell adhesion; and vasculature development. Located in mitochondrion. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; musculature; and sensory organ. Used to study buphthalmos. Human ortholog(s) of this gene implicated in Peters anomaly; anterior segment dysgenesis 6; breast cancer; glaucoma (multiple); and lung squamous cell carcinoma. Orthologous to human CYP1B1 (cytochrome P450 family 1 subfamily B member 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: benz[a]anthracene inducible; CP1B; CYPIB1; cytochrome P450 1B1; cytochrome P450, 1b1, benz[a]anthracene inducible; cytochrome P450CMEF; cytochrome P450EF; hydroperoxy icosatetraenoate dehydratase; P4501b1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391780,014,369 - 80,022,490 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1780,008,966 - 80,022,490 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381779,706,940 - 79,715,061 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1779,701,537 - 79,715,061 (-)Ensemblmm10GRCm38
MGSCv371780,106,293 - 80,114,381 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361779,615,279 - 79,623,367 (-)NCBIMGSCv36mm8
Celera1784,018,414 - 84,026,502 (-)NCBICelera
Cytogenetic Map17E3NCBI
cM Map1750.3NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(+-)-suloctidil  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(-)-trans-epsilon-viniferin  (ISO)
(E)-cinnamyl alcohol  (ISO)
(R)-pantothenic acid  (ISO)
(S)-duloxetine hydrochloride  (ISO)
(S)-naringenin  (EXP,ISO)
(S)-nicotine  (ISO)
1,2,3,4,6,7,8-Heptachlorodibenzodioxin  (ISO)
1,2,3,4,6,7,8-Heptachlorodibenzofuran  (ISO)
1,2,3,4,7,8-Hexachlorodibenzofuran  (ISO)
1,2,3,6,7,8-Hexachlorodibenzodioxin  (ISO)
1,2,3,7,8-Pentachlorodibenzodioxin  (EXP,ISO)
1,3-Dinitropyrene  (ISO)
1,4-dihydroxy-2-naphthoic acid  (EXP,ISO)
1,4-naphthoquinone  (ISO)
1,8-Dinitropyrene  (ISO)
1-[4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl]-2-(4-chlorophenoxy)ethanone  (ISO)
1-Aminopyrene  (ISO)
1-hydroxy-2-naphthoic acid  (EXP,ISO)
1-methylnaphthalene  (ISO)
1-methylphenanthrene  (ISO)
1-methyltryptophan  (ISO)
1-naphthol  (EXP,ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
1-nitropyrene  (EXP,ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2',5'-Dideoxyadenosine  (ISO)
2'-deoxyguanosine  (ISO)
2'-hydroxychalcone  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',4,5-tetrachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3',4,4',5,5'-Hexachlorobiphenyl  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (EXP,ISO)
2,3,3',4,4',5,5'-Heptachlorobiphenyl  (ISO)
2,3,3',4,4',5-Hexachlorobiphenyl  (EXP,ISO)
2,3,4,3',4'-Pentachlorobiphenyl  (ISO)
2,3,4,7,8-Pentachlorodibenzofuran  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4-D  (ISO)
2,4-diaminotoluene  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dichlorophenol  (ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (EXP)
2-acetamidofluorene  (EXP)
2-hydroxy-17beta-estradiol  (ISO)
2-methylnaphthalene  (ISO)
2-naphthol  (EXP)
3',4'-dimethoxyflavone  (ISO)
3',5'-cyclic AMP  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',4,4'-tetrachlorobiphenyl  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP,ISO)
3,3'-diindolylmethane  (ISO)
3,4,5,3',4',5'-Hexachlorobiphenyl  (ISO)
3,4-dichloroaniline  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-[[oxo(pyridin-4-yl)methyl]hydrazo]-N-(phenylmethyl)propanamide  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP,ISO)
3-methylcholanthrene  (EXP,ISO)
3-Methylchrysene  (ISO)
3-Nitrobenzanthrone  (ISO)
3-Nitrofluoranthene  (ISO)
4',5,7-trihydroxy-3'-methoxyflavone  (ISO)
4',5,7-Trimethoxyflavone  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-hydroxy-17beta-estradiol  (ISO)
4-hydroxychalcone  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (EXP)
4-methoxy-17beta-estradiol  (ISO)
4-Methylchrysene  (ISO)
4-nonylphenol  (ISO)
5,6-dichloro-1-beta-D-ribofuranosyl-1H-benzimidazole  (ISO)
5,7-dihydroxy-4'-methoxyflavone  (EXP,ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
5-Hydroxyflavone  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP,ISO)
5-methoxyindole  (EXP)
5-Methylchrysene  (ISO)
6-chrysenamine  (EXP)
6-hydroxyluteolin  (ISO)
6-Methylchrysene  (ISO)
6-Nitrobenzo[a]pyrene  (ISO)
6-Nitrochrysene  (ISO)
6-prenylnaringenin  (ISO)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (EXP,ISO)
7-hydroxyflavone  (ISO)
8-Br-cAMP  (ISO)
9-phenanthrol  (ISO)
abacavir  (ISO)
acenaphthene  (ISO)
acenaphthylene  (EXP,ISO)
actinomycin D  (EXP,ISO)
adefovir pivoxil  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
aflatoxin M1  (ISO)
AH23848  (ISO)
albendazole  (ISO)
aldehydo-D-glucose  (ISO)
alizarin  (ISO)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (EXP,ISO)
Aloe emodin  (ISO)
alpha-naphthoflavone  (EXP,ISO)
amentoflavone  (ISO)
amiloride  (ISO)
amiodarone  (ISO)
amitrole  (ISO)
amlodipine  (ISO)
ammonium chloride  (ISO)
amodiaquine  (ISO)
andrographolide  (EXP)
aniline  (ISO)
anthracene  (ISO)
anthraflavic acid  (ISO)
antimonite  (ISO)
antirheumatic drug  (ISO)
apigenin  (EXP,ISO)
apomorphine  (ISO)
arachidonic acid  (EXP,ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite ion  (EXP)
arsenite(3-)  (EXP,ISO)
arsenous acid  (ISO)
atrazine  (EXP,ISO)
avobenzone  (ISO)
baicalein  (ISO)
belinostat  (ISO)
benoxaprofen  (ISO)
benzarone  (ISO)
benzbromarone  (ISO)
benzene  (ISO)
benzene-1,2,4-triol  (ISO)
benziodarone  (ISO)
Benzo[a]fluorene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzo[a]pyrene-7,8-diol  (ISO)
benzo[a]pyrene-7,8-dione  (ISO)
benzo[b]fluoranthene  (EXP,ISO)
Benzo[b]fluorene  (ISO)
Benzo[c]fluorene  (ISO)
benzo[c]phenanthrene  (ISO)
benzo[e]pyrene  (EXP,ISO)
Benzo[ghi]perylene  (ISO)
Benzo[j]fluoranthene  (ISO)
Benzo[k]fluoranthene  (EXP,ISO)
bergomottin  (ISO)
beta-carboline  (ISO)
beta-naphthoflavone  (EXP,ISO)
bexarotene  (ISO)
bicalutamide  (ISO)
biochanin A  (EXP,ISO)
biotin  (ISO)
biphenyl  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
brefeldin A  (ISO)
bromocriptine  (ISO)
bucladesine  (EXP)
butan-1-ol  (ISO)
Butylbenzyl phthalate  (EXP,ISO)
Butylparaben  (ISO)
butyric acid  (EXP,ISO)
C60 fullerene  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
cadmium telluride  (EXP)
caffeine  (EXP)
calciol  (ISO)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
calyculin A  (ISO)
carbon monoxide  (EXP)
carbon nanotube  (EXP,ISO)
carbonyl sulfide  (ISO)
carvedilol  (ISO)
cefaloridine  (ISO)
ceric oxide  (ISO)
CGP 52608  (ISO)
chelerythrine  (EXP)
CHIR 99021  (ISO)
chloroacetaldehyde  (ISO)
chlorophyllin  (ISO)
chloropicrin  (ISO)
chloroprene  (EXP)
chlorpromazine  (ISO)
chlorpyrifos  (ISO)
chlorzoxazone  (ISO)
choline  (EXP)
Chorionic gonadotropin  (ISO)
chromium atom  (ISO)
chromium(6+)  (EXP,ISO)
chrysene  (EXP,ISO)
chrysin  (ISO)
chrysin 5,7-dimethyl ether  (ISO)
chrysophanol  (ISO)
cidofovir anhydrous  (ISO)
cinnamyl alcohol  (ISO)
cirsiliol  (ISO)
cisplatin  (ISO)
citral  (ISO)
clevidipine  (ISO)
clodronic acid  (ISO)
clomiphene  (ISO)
clomipramine  (ISO)
clopidogrel  (ISO)
clothianidin  (ISO)
clotrimazole  (ISO)
clozapine  (ISO)
Clozapine N-oxide  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cortisol  (ISO)
coumestrol  (ISO)
curcumin  (ISO)
Cyclofenil  (ISO)
cycloheximide  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
cypermethrin  (EXP)
D-glucose  (ISO)
daidzein  (EXP,ISO)
daunorubicin  (ISO)
DDE  (ISO)
DDT  (ISO)
decabromodiphenyl ether  (ISO)
dehydroepiandrosterone  (EXP)
deoxynivalenol  (ISO)
dexamethasone  (EXP,ISO)
dextromethorphan  (EXP)
Diallyl sulfide  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
Dibenz[a,c]anthracene  (ISO)
dibenz[a,h]anthracene  (EXP,ISO)
Dibenzo[a,e]pyrene  (ISO)
dibenzo[a,l]pyrene  (EXP,ISO)
dibenzofurans  (EXP)
dibromoacetic acid  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
dichloromethane  (ISO)
diclofenac  (EXP)
dieldrin  (ISO)
diethyl phthalate  (ISO)
diethylstilbestrol  (EXP,ISO)
difluorine  (ISO)
dihydroergotamine  (EXP)
dimethyl sulfoxide  (EXP,ISO)
dimethylarsinic acid  (ISO)
diosmetin  (ISO)
dioxygen  (EXP,ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
disulfiram  (ISO)
diuron  (ISO)
dopamine  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
doxycycline  (ISO)
Droloxifene  (ISO)
dronedarone  (ISO)
ebrotidine  (ISO)
ellagic acid  (EXP)
ellipticine  (EXP,ISO)
emodin  (ISO)
enilconazole  (ISO)
epoxiconazole  (ISO)
erlotinib hydrochloride  (ISO)
Erucin  (ISO)
estrone  (ISO)
ethanol  (EXP,ISO)
ethoxyquin  (ISO)
ethylbenzene  (ISO)
ethylisopropylamiloride  (ISO)
eugenol  (ISO)
eupatorin  (ISO)
Evodiamine  (ISO)
felodipine  (ISO)
fenofibrate  (ISO)
ferric oxide  (ISO)
filipin III  (ISO)
fingolimod hydrochloride  (ISO)
flavanone  (EXP,ISO)
flavone  (ISO)
flavonol  (ISO)
fluoranthene  (EXP,ISO)
fluorine atom  (ISO)
fluoxetine  (ISO)
flutamide  (ISO)
folic acid  (EXP)
formaldehyde  (ISO)
formononetin  (ISO)
fructose  (EXP)
fulvestrant  (EXP,ISO)
fumonisin B1  (ISO)
furan  (ISO)
galangin  (EXP,ISO)
gamma-hexachlorocyclohexane  (ISO)
gefitinib  (ISO)
genistein  (EXP,ISO)
genkwanin  (ISO)
gentamycin  (ISO)
geranial  (ISO)
geraniol  (ISO)
glafenine  (ISO)
glucaric acid  (EXP)
glucoerucin  (ISO)
glucoerucin(1-)  (ISO)
glucoraphanin  (ISO)
glucose  (ISO)
glutathione  (ISO)
hesperetin  (ISO)
hexachlorobenzene  (ISO)
homoeriodictyol  (ISO)
hydrogen peroxide  (ISO)
hydrogen sulfide  (EXP)
hydroquinone  (ISO)
ICI 118551  (ISO)
ifosfamide  (ISO)
imperatorin  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
indirubin  (ISO)
indole-3-acetic acid  (ISO)
indole-3-methanol  (ISO)
indoles  (ISO)
indometacin  (ISO)
indoxyl sulfate  (EXP,ISO)
iron dichloride  (ISO)
isoflavones  (EXP)
isoimperatorin  (ISO)
isoliquiritigenin  (ISO)
isopimpinellin  (ISO)
isoprenaline  (EXP,ISO)
isoproturon  (EXP)
isorhamnetin  (ISO)
Isradipine  (ISO)
ivermectin  (EXP,ISO)
kaempferol  (ISO)
ketoconazole  (EXP,ISO)
KN-93  (ISO)
kynurenine  (ISO)
L-methionine  (EXP)
L-tryptophan  (ISO)
lansoprazole  (ISO)
lapatinib  (ISO)
laquinimod  (ISO)
lead diacetate  (ISO)
leflunomide  (ISO)
Licochalcone A  (ISO)
linuron  (EXP,ISO)
lithocholic acid  (EXP)
lovastatin  (ISO)
luteolin  (ISO)
LY294002  (ISO)
lycopene  (EXP)
medroxyprogesterone acetate  (ISO)
mefenamic acid  (ISO)
MeIQx  (ISO)
melatonin  (ISO)
menadione  (ISO)
mephenytoin  (EXP)
mercury atom  (EXP)
mercury dibromide  (ISO)
mercury dichloride  (EXP)
mercury(0)  (EXP)
metformin  (ISO)
methoxsalen  (EXP,ISO)
methoxychlor  (EXP,ISO)
methylmercury chloride  (ISO)
metoclopramide  (ISO)
midazolam  (EXP)
mifepristone  (ISO)
mitoxantrone  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
monobenzyl phthalate  (EXP)
Monobutylphthalate  (EXP)
monocrotaline  (EXP)
monoethyl phthalate  (EXP)
montelukast  (ISO)
myricetin  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-desmethylclozapine  (ISO)
N-Desmethyltamoxifen  (ISO)
N-hydroxy-PhIP  (ISO)
N-nitrosodiethylamine  (ISO)
NADP zwitterion  (ISO)
NADP(+)  (ISO)
naphthalene  (ISO)
naphthalenes  (ISO)
naringin  (ISO)
NCX-4040  (ISO)
nefazodone  (ISO)
nicardipine  (ISO)
nickel atom  (ISO)
nickel dichloride  (EXP)
nickel subsulfide  (ISO)
nickel sulfate  (ISO)
nicotine  (ISO)
nifedipine  (EXP,ISO)
nilutamide  (ISO)
nimesulide  (ISO)
nobiletin  (ISO)
Nonylphenol  (ISO)
NS-398  (ISO)
O-methyleugenol  (ISO)
o-xylene  (ISO)
okadaic acid  (ISO)
olsalazine  (ISO)
oltipraz  (ISO)
omeprazole  (EXP,ISO)
organophosphorus compound  (ISO)
organoselenium compound  (ISO)
oxaliplatin  (ISO)
oxyphenisatine acetate  (ISO)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
paricalcitol  (ISO)
pazopanib  (ISO)
pentachlorobiphenyl  (ISO)
pentamidine  (ISO)
perfluorohexanesulfonic acid  (EXP)
perfluorononanoic acid  (ISO)
Pf-06840003  (EXP,ISO)
phenanthrene  (ISO)
phenanthrenes  (ISO)
Phenelzine  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
phenytoin  (EXP)
PhIP  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phosphorus atom  (ISO)
phosphorus(.)  (ISO)
pifithrin-alpha hydrobromide  (EXP,ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP)
potassium chromate  (ISO)
potassium dichromate  (EXP)
pravastatin  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
primaquine  (ISO)
procarbazine  (ISO)
prochloraz  (ISO)
progesterone  (ISO)
propafenone  (ISO)
propiconazole  (ISO)
propranolol  (ISO)
prostaglandin E2  (ISO)
protein kinase inhibitor  (ISO)
pyrantel  (ISO)
pyrene  (EXP,ISO)
quartz  (ISO)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-glucofuranoside  (ISO)
quercetin 3-O-beta-D-glucopyranoside  (ISO)
quercitrin  (ISO)
quinidine  (EXP)
rabeprazole  (ISO)
resveratrol  (EXP,ISO)
rifampicin  (EXP,ISO)
Riluzole  (ISO)
ritonavir  (ISO)
Rutecarpine  (ISO)
rutin  (ISO)
salicylamide  (ISO)
Salinomycin  (ISO)
sanguinarine  (ISO)
SB 431542  (ISO)
scutellarein  (ISO)
senecionine  (ISO)
sildenafil citrate  (ISO)
silicon dioxide  (ISO)
simvastatin  (ISO)
sinensetin  (ISO)
sirolimus  (ISO)
skatole  (ISO)
sodium acetate trihydrate  (EXP,ISO)
sodium arsenate  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP,ISO)
sodium propionate  (ISO)
sorafenib  (ISO)
StemRegenin 1  (ISO)
steviol  (ISO)
stevioside  (ISO)
stilbenoid  (ISO)
succimer  (ISO)
Sudan I  (ISO)
sulfadimethoxine  (ISO)
sulforaphane  (ISO)
sulindac  (ISO)
sulindac sulfide  (ISO)
sunitinib  (ISO)
suramin  (ISO)
tamoxifen  (EXP,ISO)
tangeretin  (ISO)
temozolomide  (ISO)
Temsirolimus  (ISO)
terbinafine  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP)
tetrahydrocurcumin  (EXP)
tetraphene  (EXP,ISO)
thapsigargin  (ISO)
thiram  (ISO)
ticlopidine  (ISO)
titanium dioxide  (EXP,ISO)
tolcapone  (ISO)
toluene  (ISO)
tolvaptan  (ISO)
topotecan  (ISO)
tranilast  (ISO)
trazodone  (ISO)
triadimefon  (ISO)
trichlorobiphenyl  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triclocarban  (EXP,ISO)
triclosan  (EXP,ISO)
trimethylarsine oxide  (EXP)
triphenylene  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (EXP,ISO)
Tungsten carbide  (ISO)
undecane  (ISO)
urethane  (ISO)
Valacyclovir hydrochloride  (ISO)
valdecoxib  (ISO)
valproic acid  (EXP,ISO)
vanadium atom  (EXP)
vanadium(0)  (EXP)
vancomycin  (EXP)
varenicline  (ISO)
verapamil  (EXP)
vinclozolin  (ISO)
voriconazole  (ISO)
vorinostat  (ISO)
wortmannin  (ISO)
Yessotoxin  (ISO)
zafirlukast  (ISO)
zaragozic acid A  (EXP,ISO)
zearalenone  (ISO)
zidovudine  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adrenal gland development  (ISO)
angiogenesis  (IMP)
arachidonate metabolic process  (IDA,IEA,ISO)
benzene-containing compound metabolic process  (IDA,IMP,ISO)
blood vessel endothelial cell migration  (IMP)
blood vessel morphogenesis  (IMP)
cell adhesion  (IMP)
cellular response to cAMP  (ISO)
cellular response to cortisol stimulus  (ISO)
cellular response to hydrogen peroxide  (IMP)
cellular response to luteinizing hormone stimulus  (ISO)
cellular response to progesterone stimulus  (ISO)
cellular response to toxic substance  (ISO)
cellular response to tumor necrosis factor  (ISO)
collagen fibril organization  (IMP)
dibenzo-p-dioxin metabolic process  (IMP)
DNA modification  (ISO)
endothelial cell migration  (IMP)
endothelial cell-cell adhesion  (IMP)
estrogen metabolic process  (IBA,IDA,IEA,ISO)
estrous cycle  (ISO)
fatty acid metabolic process  (IEA)
ganglion development  (ISO)
intrinsic apoptotic signaling pathway in response to oxidative stress  (IMP)
lipid metabolic process  (IEA)
male gonad development  (ISO)
membrane lipid catabolic process  (IMP)
negative regulation of cell adhesion mediated by integrin  (IMP)
negative regulation of cell migration  (IMP)
negative regulation of cell population proliferation  (IMP)
negative regulation of NF-kappaB transcription factor activity  (IMP)
nitric oxide biosynthetic process  (IMP)
positive regulation of angiogenesis  (IMP)
positive regulation of apoptotic process  (IMP,ISO)
positive regulation of DNA biosynthetic process  (ISO)
positive regulation of reactive oxygen species metabolic process  (ISO)
positive regulation of receptor signaling pathway via JAK-STAT  (IMP)
positive regulation of smooth muscle cell migration  (ISO)
positive regulation of translation  (ISO)
positive regulation of vascular endothelial growth factor production  (IMP)
regulation of reactive oxygen species metabolic process  (IMP)
response to 3-methylcholanthrene  (ISO)
response to arsenic-containing substance  (ISO)
response to dexamethasone  (ISO)
response to estradiol  (ISO)
response to follicle-stimulating hormone  (ISO)
response to indole-3-methanol  (ISO)
response to nutrient  (ISO)
response to steroid hormone  (ISO)
response to toxic substance  (IMP,ISO)
retina vasculature development in camera-type eye  (IMP)
retinal blood vessel morphogenesis  (IMP)
retinal metabolic process  (IDA,IEA,ISO)
retinol metabolic process  (IDA,IEA,ISO)
steroid catabolic process  (IBA)
steroid metabolic process  (IEA,ISO,ISS)
toxin metabolic process  (IBA,IMP)
trabecular meshwork development  (IMP)
xenobiotic catabolic process  (IBA)
xenobiotic metabolic process  (IEA,ISO,ISS)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. 3-methylcholanthrene and benzo(a)pyrene modulate cardiac cytochrome P450 gene expression and arachidonic acid metabolism in male Sprague Dawley rats. Aboutabl ME, etal., Br J Pharmacol. 2009 Dec;158(7):1808-19. doi: 10.1111/j.1476-5381.2009.00461.x.
2. Molecular and clinical evaluation of primary congenital glaucoma in Kuwait. Alfadhli S, etal., Am J Ophthalmol. 2006 Mar;141(3):512-6.
3. Congenital glaucoma: CYP1B1 mutations in Israeli Bedouin kindreds. Bar-Yosef U, etal., J Glaucoma. 2010 Jan;19(1):35-8. doi: 10.1097/IJG.0b013e3181a98b6f.
4. Leu432Val polymorphism in CYP1B1 as a susceptible factor towards predisposition to primary open-angle glaucoma. Bhattacharjee A, etal., Mol Vis. 2008 May 8;14:841-50.
5. Identification of a rat adrenal cytochrome P450 active in polycyclic hydrocarbon metabolism as rat CYP1B1. Demonstration of a unique tissue-specific pattern of hormonal and aryl hydrocarbon receptor-linked regulation. Bhattacharyya KK, etal., J Biol Chem 1995 May 12;270(19):11595-602.
6. Glaucoma-associated CYP1B1 mutations share similar haplotype backgrounds in POAG and PACG phenotypes. Chakrabarti S, etal., Invest Ophthalmol Vis Sci. 2007 Dec;48(12):5439-44.
7. Cytochrome P450 1B1 expression in rat esophageal tumorigenesis promoted by gastric and duodenal reflux. Devlin AH, etal., Mol Carcinog. 2009 Feb;48(2):110-7. doi: 10.1002/mc.20459.
8. Molecular basis of Peters anomaly in Saudi Arabia. Edward D, etal., Ophthalmic Genet. 2004 Dec;25(4):257-70.
9. Molecular analysis of CYP1B1 in Omani patients with primary congenital glaucoma: a pilot study. El-Gayar S, etal., Mol Vis. 2009 Jul 8;15:1325-31.
10. LncRNA H19 suppresses pyroptosis of cardiomyocytes to attenuate myocardial infarction in a PBX3/CYP1B1-dependent manner. Han Y, etal., Mol Cell Biochem. 2021 Mar;476(3):1387-1400. doi: 10.1007/s11010-020-03998-y. Epub 2021 Jan 3.
11. Screening of CYP1B1 and MYOC in Moroccan families with primary congenital glaucoma: three novel mutations in CYP1B1. Hilal L, etal., Mol Vis. 2010 Jul 2;16:1215-26.
12. Cytochrome P450 1B1 contributes to angiotensin II-induced hypertension and associated pathophysiology. Jennings BL, etal., Hypertension. 2010 Oct;56(4):667-74. doi: 10.1161/HYPERTENSIONAHA.110.154518. Epub 2010 Aug 30.
13. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
14. Role of CYP1B1, MYOC, OPTN, and OPTC genes in adult-onset primary open-angle glaucoma: predominance of CYP1B1 mutations in Indian patients. Kumar A, etal., Mol Vis. 2007 Apr 30;13:667-76.
15. Modification of ocular defects in mouse developmental glaucoma models by tyrosinase. Libby RT, etal., Science 2003 Mar 7;299(5612):1578-81.
16. Identification of FGF10 targets in the embryonic lung epithelium during bud morphogenesis. Lu J, etal., J Biol Chem 2005 Feb 11;280(6):4834-41. Epub 2004 Nov 19.
17. Association of a common coding polymorphism (N453S) of the cytochrome P450 1B1 (CYP1B1) gene with optic disc cupping and visual field alteration in French patients with primary open-angle glaucoma. Melki R, etal., Mol Vis. 2005 Nov 23;11:1012-7.
18. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
19. MGDs mouse GO annotations MGD data from the GO Consortium
20. Survey of familial glaucoma shows a high incidence of cytochrome P450, family 1, subfamily B, polypeptide 1 (CYP1B1) mutations in non-consanguineous congenital forms in a Spanish population. Milla E, etal., Mol Vis. 2013 Aug 4;19:1707-22. Print 2013.
21. Large-scale screen for genes controlling mammalian embryogenesis, using high-throughput gene expression analysis in mouse embryos. Neidhardt L, etal., Mech Dev 2000 Nov;98(1-2):77-94.
22. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
23. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
24. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
25. Identification of a single ancestral CYP1B1 mutation in Slovak Gypsies (Roms) affected with primary congenital glaucoma. Plasilova M, etal., J Med Genet. 1999 Apr;36(4):290-4.
26. Metabolomic profiling reveals potential markers and bioprocesses altered in bladder cancer progression. Putluri N, etal., Cancer Res. 2011 Dec 15;71(24):7376-86. doi: 10.1158/0008-5472.CAN-11-1154. Epub 2011 Oct 11.
27. Mouse MP Annotation Import Pipeline RGD automated import pipeline
28. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
29. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
30. Diet-relevant phytochemical intake affects the cardiac AhR and nrf2 transcriptome and reduces heart failure in hypertensive rats. Seymour EM, etal., J Nutr Biochem. 2013 Sep;24(9):1580-6. doi: 10.1016/j.jnutbio.2013.01.008. Epub 2013 Mar 22.
31. Primary congenital glaucoma: a novel single-nucleotide deletion and varying phenotypic expression for the 1,546-1,555dup mutation in the GLC3A (CYP1B1) gene in 2 families of different ethnic origin. Soley GC, etal., J Glaucoma. 2003 Feb;12(1):27-30.
32. Identification of three different truncating mutations in cytochrome P4501B1 (CYP1B1) as the principal cause of primary congenital glaucoma (Buphthalmos) in families linked to the GLC3A locus on chromosome 2p21. Stoilov I, etal., Hum Mol Genet. 1997 Apr;6(4):641-7.
33. Expression of the aryl hydrocarbon receptor/transcription factor (AhR) and AhR-regulated CYP1 gene transcripts in a rat model of mammary tumorigenesis. Trombino AF, etal., Breast Cancer Res Treat. 2000 Sep;63(2):117-31.
34. Aryl hydrocarbon receptor activation and overexpression upregulated fibroblast growth factor-9 in human lung adenocarcinomas. Wang CK, etal., Int J Cancer. 2009 Aug 15;125(4):807-15. doi: 10.1002/ijc.24348.
35. Association of CYP1B1 genetic polymorphism with incidence to breast and lung cancer. Watanabe J, etal., Pharmacogenetics. 2000 Feb;10(1):25-33.
36. Induction of P450 1A by 3-methylcholanthrene protects mice from aristolochic acid-I-induced acute renal injury. Xue X, etal., Nephrol Dial Transplant. 2008 Oct;23(10):3074-81. doi: 10.1093/ndt/gfn262. Epub 2008 May 21.
37. Investigation of CYP1B1 mutations in Chinese patients with primary congenital glaucoma. Yang M, etal., Mol Vis. 2009;15:432-7. Epub 2009 Feb 27.
38. Inhibition of CYP1B1 ameliorates cardiac hypertrophy induced by uremic toxin. Zhang Y, etal., Mol Med Rep. 2020 Jan;21(1):393-404. doi: 10.3892/mmr.2019.10810. Epub 2019 Nov 11.
Additional References at PubMed
PMID:1910294   PMID:7505439   PMID:7772257   PMID:8195121   PMID:9367523   PMID:9377560   PMID:9772216   PMID:10051580   PMID:10349636   PMID:10464095   PMID:10503904   PMID:10725249  
PMID:10871058   PMID:10910056   PMID:11042159   PMID:11076861   PMID:11577022   PMID:11673863   PMID:12464254   PMID:12477932   PMID:12745259   PMID:14681479   PMID:14740995   PMID:15028720  
PMID:15258110   PMID:15359218   PMID:15580705   PMID:15582647   PMID:15752708   PMID:15843505   PMID:16141072   PMID:16141073   PMID:16377763   PMID:16636061   PMID:17166882   PMID:17325023  
PMID:17560947   PMID:17709388   PMID:17914928   PMID:17997381   PMID:18287559   PMID:18372398   PMID:18391535   PMID:18452486   PMID:18779384   PMID:18953896   PMID:19005183   PMID:19138945  
PMID:19208226   PMID:19576202   PMID:20032512   PMID:20088394   PMID:21303932   PMID:21386911   PMID:21389345   PMID:21677750   PMID:21785971   PMID:21873635   PMID:22184325   PMID:22859684  
PMID:22960141   PMID:23047765   PMID:23108654   PMID:23112163   PMID:23275542   PMID:23276798   PMID:23376040   PMID:23519266   PMID:23531410   PMID:23568032   PMID:23692925   PMID:23776235  
PMID:23821647   PMID:23956430   PMID:23979599   PMID:24088896   PMID:24497629   PMID:24639079   PMID:24684199   PMID:25233073   PMID:25233930   PMID:25261715   PMID:25315223   PMID:25694484  
PMID:25703193   PMID:25868132   PMID:25870196   PMID:26049101   PMID:26573711   PMID:26893163   PMID:26928804   PMID:26990437   PMID:27036855   PMID:27113764   PMID:27235555   PMID:27301358  
PMID:28146477   PMID:28251434   PMID:28416584   PMID:28583802   PMID:30352686   PMID:30371217   PMID:30372497   PMID:30550785   PMID:30576387   PMID:30728831   PMID:30892936   PMID:30923189  
PMID:31112136   PMID:31220272   PMID:31852820   PMID:31948482   PMID:32027669   PMID:32255961   PMID:32330152   PMID:33748124   PMID:34321999   PMID:35734174   PMID:36768740   PMID:37348155  
PMID:37524872   PMID:38069208   PMID:38081439   PMID:38429921   PMID:38612589   PMID:39321267   PMID:39798644  


Genomics

Comparative Map Data
Cyp1b1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391780,014,369 - 80,022,490 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1780,008,966 - 80,022,490 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381779,706,940 - 79,715,061 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1779,701,537 - 79,715,061 (-)Ensemblmm10GRCm38
MGSCv371780,106,293 - 80,114,381 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361779,615,279 - 79,623,367 (-)NCBIMGSCv36mm8
Celera1784,018,414 - 84,026,502 (-)NCBICelera
Cytogenetic Map17E3NCBI
cM Map1750.3NCBI
CYP1B1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38238,067,509 - 38,076,151 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl238,066,973 - 38,109,902 (-)Ensemblhg38GRCh38
GRCh37238,294,652 - 38,303,293 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36238,148,250 - 38,156,796 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34238,206,396 - 38,214,943NCBI
Celera238,135,623 - 38,144,201 (-)NCBICelera
Cytogenetic Map2p22.2NCBI
HuRef238,034,680 - 38,043,258 (-)NCBIHuRef
CHM1_1238,224,106 - 38,232,684 (-)NCBICHM1_1
T2T-CHM13v2.0238,074,395 - 38,083,037 (-)NCBIT2T-CHM13v2.0
Cyp1b1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8621,093,927 - 21,103,091 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl621,078,146 - 21,103,142 (+)EnsemblGRCr8
mRatBN7.2615,342,312 - 15,350,886 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl615,342,344 - 15,350,917 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx615,640,765 - 15,646,482 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0615,962,952 - 15,968,669 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0615,459,216 - 15,464,934 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.062,308,179 - 2,316,739 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl62,307,808 - 2,316,722 (-)Ensemblrn6Rnor6.0
Rnor_5.062,294,952 - 2,300,644 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.462,548,224 - 2,553,767 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera615,009,941 - 15,015,671 (+)NCBICelera
RGSC_v3.162,545,648 - 2,553,767 (-)NCBI
Cytogenetic Map6q12NCBI
LOC102009223
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554415,803,032 - 5,812,131 (-)Ensembl
ChiLan1.0NW_0049554415,803,397 - 5,812,131 (-)NCBIChiLan1.0ChiLan1.0
CYP1B1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21288,409,864 - 88,419,099 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A88,413,479 - 88,423,073 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A38,087,863 - 38,096,529 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A38,851,000 - 38,859,883 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A38,851,000 - 38,859,824 (-)EnsemblpanPan2panpan1.1
CYP1B1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11730,273,281 - 30,278,554 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1730,272,749 - 30,278,554 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1730,086,594 - 30,091,868 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01730,923,029 - 30,928,301 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1730,922,243 - 30,928,321 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11730,148,312 - 30,153,581 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01730,216,274 - 30,221,549 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01730,431,572 - 30,436,860 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
LOC101970101
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629241,681,103 - 41,689,696 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936663348,368 - 355,191 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936663345,021 - 355,188 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CYP1B1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3102,195,741 - 102,205,683 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.13102,195,743 - 102,205,687 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
CYP1B1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11469,318,713 - 69,327,277 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1469,319,495 - 69,324,157 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604542,635,474 - 42,644,623 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
LOC101701066
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473819,638,456 - 19,647,497 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473819,639,215 - 19,647,807 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Cyp1b1
342 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:801
Count of miRNA genes:532
Interacting mature miRNAs:608
Transcripts:ENSMUST00000024894
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4141758Pstc5_mperiosteal circumference 5 (mouse)Not determined175710765191107803Mouse
4142201Obrq15_mobesity resistance QTL 15 (mouse)Not determined5753444780885776Mouse
1357532Bmch7_mbone mechanical trait 7 (mouse)Not determined175175842585758612Mouse
4141879Chlq9_mcirculating hormone level QTL 9 (mouse)Not determined175175842585758612Mouse
11528551Sluc32_msusceptibility to lung cancer 32 (mouse)176230101095294699Mouse
1301338Lmr1_mleishmaniasis resistance 1 (mouse)Not determined171008134086996400Mouse
1357528Nhdlq3_mnon-HDL QTL 3 (mouse)Not determined177339513295294699Mouse
12910536Nrq8a_mnoise-induced hearing loss resistant QTL 8a (mouse)175710765191107803Mouse
12910537Nrq8_mnoise-induced hearing loss resistant QTL 8 (mouse)175710765191107803Mouse
4141040Hmtb9_mhemostasis and thrombosis rebleeding time 9 (mouse)Not determined5758908991589197Mouse
4142256Nilac12_mnicotine induced locomotor activity 12 (mouse)Not determined176894131995294699Mouse
1302017Aliq3_macute lung injury QTL 3 (mouse)Not determined176388554895294699Mouse
1357447Heal13_mwound healing/regeneration 13 (mouse)Not determined175710765191107803Mouse
26884428Cvht3_mcranial vault height 3, 5 week (mouse)174651092682407429Mouse
14928308Manh82_mmandible shape 82 (mouse)176631524395294699Mouse
1357646Axtq3_manxiety QTL 3 (mouse)Not determined177458908990395270Mouse
1301107Scc4_mcolon tumor susceptibility 4 (mouse)Not determined176230101095294699Mouse
11039498Ltpr7b_mLeishmania tropica response 7b (mouse)177070119895294699Mouse
11039499Ltpr7a_mLeishmania tropica response 7a (mouse)177070119895294699Mouse
1357552Aaj4_manxiety in A/J 4 (mouse)Not determined177458908990395270Mouse
11039500Ltpr7c_mLeishmania tropica response 7c (mouse)177070119895294699Mouse
4141011Bmd26_mbone mineral density 26 (mouse)Not determined175710765191107803Mouse
1300735Pgia20_mproteoglycan induced arthritis 20 (mouse)Not determined175710765191107803Mouse
1357754Ahl3_mage related hearing loss 3 (mouse)Not determined175020395784204103Mouse
4142414Pregq4_mpregnancy QTL 4 (mouse)Not determined175753444793507179Mouse
11039514Ltpr7_mLeishmania tropica response 7 (mouse)177070119895294699Mouse
1301728Ffal1_mfree fatty acid level 1 (mouse)Not determined176521493895294699Mouse
13464254Ifvrq3_minfluenza virus resistance QTL 3 (mouse)176795765583908089Mouse
4141195Nilac11_mnicotine induced locomotor activity 11 (mouse)Not determined177339513295294699Mouse
4142150Stheal11_msoft tissue heal 11 (mouse)Not determined171228621183361768Mouse
4141697Hbnr3_mHeligmosomoides bakeri nematode resistance 3 (mouse)Not determined7410765193507179Mouse

Markers in Region
Cyp1b1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381779,713,430 - 79,714,277UniSTSGRCm38
MGSCv371780,112,770 - 80,113,617UniSTSGRCm37
Celera1784,024,891 - 84,025,738UniSTS
Cytogenetic Map17E3UniSTS
cM Map17 UniSTS
U03283  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381779,707,205 - 79,707,341UniSTSGRCm38
MGSCv371780,106,545 - 80,106,681UniSTSGRCm37
Celera1784,018,666 - 84,018,802UniSTS
Cytogenetic Map17E3UniSTS
Whitehead/MRC_RH17920.68UniSTS
Cyp1b1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map17E3UniSTS
Cyp1b1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map17E3UniSTS
Cyp1b1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map17E3UniSTS
Cyp1b1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map17E3UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000024894   ⟹   ENSMUSP00000024894
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1780,014,382 - 80,022,470 (-)Ensembl
GRCm38.p6 Ensembl1779,706,953 - 79,715,041 (-)Ensembl
Ensembl Acc Id: ENSMUST00000234361   ⟹   ENSMUSP00000157049
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1780,014,323 - 80,022,490 (-)Ensembl
GRCm38.p6 Ensembl1779,706,894 - 79,715,061 (-)Ensembl
Ensembl Acc Id: ENSMUST00000234927   ⟹   ENSMUSP00000157101
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1780,008,966 - 80,021,084 (-)Ensembl
GRCm38.p6 Ensembl1779,701,537 - 79,713,655 (-)Ensembl
RefSeq Acc Id: NM_001364889   ⟹   NP_001351818
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391780,014,369 - 80,022,490 (-)NCBI
GRCm381779,706,940 - 79,715,061 (-)NCBI
Sequence:
RefSeq Acc Id: NM_009994   ⟹   NP_034124
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391780,014,369 - 80,022,490 (-)NCBI
GRCm381779,706,940 - 79,715,061 (-)NCBI
MGSCv371780,106,293 - 80,114,381 (-)RGD
Celera1784,018,414 - 84,026,502 (-)RGD
cM Map17 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_034124   ⟸   NM_009994
- Peptide Label: isoform 1
- UniProtKB: Q60593 (UniProtKB/Swiss-Prot),   Q3UVA8 (UniProtKB/Swiss-Prot),   Q64461 (UniProtKB/Swiss-Prot),   Q64429 (UniProtKB/Swiss-Prot),   Q80V82 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001351818   ⟸   NM_001364889
- Peptide Label: isoform 2
- UniProtKB: Q3UTK2 (UniProtKB/TrEMBL),   Q80V82 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSMUSP00000024894   ⟸   ENSMUST00000024894
Ensembl Acc Id: ENSMUSP00000157101   ⟸   ENSMUST00000234927
Ensembl Acc Id: ENSMUSP00000157049   ⟸   ENSMUST00000234361

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q64429-F1-model_v2 AlphaFold Q64429 1-543 view protein structure

Promoters
RGD ID:13676832
Promoter ID:EPDNEW_M22565
Type:initiation region
Name:Cyp1b1_1
Description:Mus musculus cytochrome P450, family 1, subfamily b, polypeptide1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381779,715,058 - 79,715,118EPDNEW
RGD ID:6827964
Promoter ID:MM_KWN:24259
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   MEF_B4,   MEF_B6
Transcripts:NM_009994,   UC008DQB.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361780,114,064 - 80,114,564 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:88590 AgrOrtholog
Ensembl Genes ENSMUSG00000024087 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000024894 ENTREZGENE
  ENSMUST00000024894.2 UniProtKB/Swiss-Prot
  ENSMUST00000234361 ENTREZGENE
Gene3D-CATH 1.10.630.10 UniProtKB/Swiss-Prot
InterPro Cyt_P450 UniProtKB/Swiss-Prot
  Cyt_P450_CS UniProtKB/Swiss-Prot
  Cyt_P450_E_grp-I UniProtKB/Swiss-Prot
  Cyt_P450_sf UniProtKB/Swiss-Prot
KEGG Report mmu:13078 UniProtKB/Swiss-Prot
MGD MGI:88590 ENTREZGENE
NCBI Gene 13078 ENTREZGENE
PANTHER CYTOCHROME P450 1B1 UniProtKB/Swiss-Prot
  STEROID 17-ALPHA-HYDROXYLASE/17,20 LYASE UniProtKB/Swiss-Prot
Pfam p450 UniProtKB/Swiss-Prot
PharmGKB CYP1B1 RGD
PhenoGen Cyp1b1 PhenoGen
PRINTS EP450I UniProtKB/Swiss-Prot
  P450 UniProtKB/Swiss-Prot
PROSITE CYTOCHROME_P450 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48264 UniProtKB/Swiss-Prot
UniProt A0A3Q4L2V1_MOUSE UniProtKB/TrEMBL
  CP1B1_MOUSE UniProtKB/Swiss-Prot
  Q3UTK2 ENTREZGENE, UniProtKB/TrEMBL
  Q3UVA8 ENTREZGENE
  Q60593 ENTREZGENE
  Q64429 ENTREZGENE
  Q64461 ENTREZGENE
  Q80V82 ENTREZGENE, UniProtKB/TrEMBL
  Q8BRY0_MOUSE UniProtKB/TrEMBL
  Q9CUA1_MOUSE UniProtKB/TrEMBL
UniProt Secondary Q3UVA8 UniProtKB/Swiss-Prot
  Q60593 UniProtKB/Swiss-Prot
  Q64461 UniProtKB/Swiss-Prot