Abcc2 (ATP-binding cassette, sub-family member 2) - Rat Genome Database

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Gene: Abcc2 (ATP-binding cassette, sub-family member 2) Mus musculus
Analyze
Symbol: Abcc2
Name: ATP-binding cassette, sub-family member 2 (Ensembl:ATP-binding cassette, sub-family C (CFTR/MRP), member 2)
RGD ID: 10368
MGI Page MGI
Description: Predicted to enable ABC-type transporter activity; bilirubin transmembrane transporter activity; and protein domain specific binding activity. Predicted to be involved in several processes, including carboxylic acid transport; intracellular chloride ion homeostasis; and mercury ion transport. Located in apical plasma membrane and intercellular canaliculus. Is expressed in foregut; genitourinary system; and liver and biliary system. Human ortholog(s) of this gene implicated in bile duct disease (multiple); bilirubin metabolic disorder (multiple); leukemia (multiple); liver disease (multiple); and lung non-small cell carcinoma. Orthologous to human ABCC2 (ATP binding cassette subfamily C member 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Abc30; AI173996; ATP-binding cassette sub-family C member 2; ATP-binding cassette, sub-family C (CFTR/MRP), member 2; canalicular multispecific organic anion transporter 1; Cmo; Cmoat; cMRP; Mr; Mrp2; multidrug resistance protein 2; multidrug resistance-associated protein 2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391943,770,747 - 43,826,771 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1943,770,631 - 43,829,179 (+)EnsemblGRCm39 Ensembl
GRCm381943,782,308 - 43,838,332 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1943,782,192 - 43,840,740 (+)EnsemblGRCm38mm10GRCm38
MGSCv371943,856,798 - 43,912,708 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361943,835,715 - 43,891,248 (+)NCBIMGSCv36mm8
Celera1944,567,463 - 44,621,438 (+)NCBICelera
Cytogenetic Map19C3NCBI
cM Map1936.67NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(+/-)-Aegeline  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (EXP)
(2,4,5-trichlorophenoxy)acetic acid  (EXP,ISO)
(RS)-coclaurine  (EXP)
(RS)-norcoclaurine  (EXP)
(S)-coclaurine  (EXP)
(S)-colchicine  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dichloroethane  (EXP)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 17-glucosiduronic acid  (ISO)
17beta-estradiol 3-benzoate  (ISO)
2',3'-dideoxyadenosine  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
2-acetamidofluorene  (EXP,ISO)
2-tert-butylhydroquinone  (ISO)
3',4',7-trihydroxyisoflavone  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3-chloropropane-1,2-diol  (ISO)
3-methyl-3H-imidazo[4,5-f]quinolin-2-amine  (EXP)
4'-epidoxorubicin  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-hydroxynon-2-enal  (ISO)
5(6)-carboxy-2',7'-dichlorofluorescein  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-chloromethylfluorescein diacetate  (ISO)
5-fluorouracil  (ISO)
5-formyltetrahydrofolic acid  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
5-methoxypsoralen  (ISO)
6-bromoindirubin-3'-oxime  (ISO)
6-carboxyfluorescein  (ISO)
6-propyl-2-thiouracil  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (EXP)
8-(4-chlorophenylthio)-cAMP  (EXP)
8-Br-cAMP  (ISO)
8-Epidiosbulbin E acetate  (EXP)
abietic acid  (ISO)
acadesine  (ISO)
acetamide  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
AICA ribonucleotide  (ISO)
aldehydo-D-glucose  (ISO)
alfacalcidol  (EXP)
all-trans-retinoic acid  (EXP)
allyl alcohol  (EXP)
alpha-amanitin  (EXP)
aluminium hydroxide  (ISO)
amiodarone  (ISO)
amphotericin B  (EXP)
ampicillin  (EXP)
angelicin  (ISO)
antimonite  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atazanavir sulfate  (ISO)
atorvastatin calcium  (EXP,ISO)
ATP  (EXP,ISO)
azathioprine  (ISO)
aztreonam  (EXP)
benzbromarone  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzoylaconine  (ISO)
benzoylhypaconine  (ISO)
benzoylmesaconine  (ISO)
benzylpenicillin  (ISO)
beta-hexachlorocyclohexane  (EXP)
beta-naphthoflavone  (EXP,ISO)
bezafibrate  (EXP,ISO)
bilirubin IXalpha  (ISO)
biochanin A  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisdemethoxycurcumin  (ISO)
bisphenol A  (EXP,ISO)
Boldine  (ISO)
bortezomib  (ISO)
bosentan  (ISO)
bromfenac  (ISO)
bromosulfophthalein  (ISO)
bucladesine  (ISO)
buspirone  (ISO)
buta-1,3-diene  (EXP)
butanal  (ISO)
butylated hydroxyanisole  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP,ISO)
calcein  (ISO)
calcein am  (ISO)
calcitriol  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
cannabidiol  (EXP)
captan  (EXP)
carbamazepine  (ISO)
carbon monoxide  (ISO)
carboplatin  (ISO)
carmustine  (ISO)
carvedilol  (EXP)
cefaloridine  (ISO)
cefalotin  (EXP)
celecoxib  (ISO)
cerivastatin  (ISO)
CGP 52608  (ISO)
chenodeoxycholic acid  (EXP,ISO)
chlorambucil  (ISO)
chlordecone  (ISO)
chlorogenic acid  (EXP)
chloroquine  (ISO)
chlorpromazine  (EXP,ISO)
chlorpyrifos  (EXP,ISO)
cholic acid  (EXP,ISO)
choline  (EXP,ISO)
chrysin  (ISO)
chrysophanol  (ISO)
ciprofloxacin  (EXP)
cisplatin  (EXP,ISO)
citalopram  (ISO)
clavulanic acid  (ISO)
clobazam  (ISO)
clofibrate  (EXP,ISO)
clofibric acid  (ISO)
clotrimazole  (ISO)
colforsin daropate hydrochloride  (ISO)
coniferyl aldehyde  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
curcumin  (EXP,ISO)
cyazofamid  (ISO)
cyclosporin A  (ISO)
cyproconazole  (EXP,ISO)
D-glucose  (ISO)
dapsone  (ISO)
daunorubicin  (ISO)
DDE  (EXP)
DDT  (ISO)
demethoxycurcumin  (ISO)
deoxycholic acid  (EXP,ISO)
desloratadine  (ISO)
dexamethasone  (ISO)
dextran sulfate  (EXP)
Diallyl sulfide  (ISO)
diarsenic trioxide  (ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
dieldrin  (ISO)
diethyl maleate  (EXP)
dimethylarsinic acid  (ISO)
Diosbulbin B  (EXP)
dioscin  (ISO)
diosgenin  (ISO)
dioxygen  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
diquat  (EXP)
disodium selenite  (EXP,ISO)
doramapimod  (EXP)
dorsomorphin  (EXP,ISO)
dothiepin  (ISO)
doxorubicin  (EXP,ISO)
DPDPE  (ISO)
E3040  (ISO)
elemental selenium  (EXP,ISO)
emodin  (EXP,ISO)
endosulfan  (ISO)
enilconazole  (EXP)
epoxiconazole  (ISO)
Erucin  (ISO)
estrone 3-sulfate  (ISO)
etacrynic acid  (ISO)
ethambutol  (ISO)
ethoxyquin  (EXP)
etoposide  (ISO)
fenofibrate  (ISO)
Fexofenadine hydrochloride  (EXP,ISO)
fipronil  (EXP,ISO)
Fluo-3  (ISO)
fluoxetine  (ISO)
flutamide  (ISO)
fluvastatin  (ISO)
formononetin  (ISO)
fosinopril  (EXP,ISO)
FR900359  (ISO)
fructose  (ISO)
fulvestrant  (ISO)
furan  (ISO)
furosemide  (ISO)
fusidic acid  (ISO)
geneticin  (ISO)
genistein  (ISO)
gentamycin  (ISO)
geraniol  (ISO)
Ginkgolide A  (ISO)
ginkgolide B  (ISO)
ginsenoside Rb2  (ISO)
ginsenoside Re  (ISO)
ginsenoside Rg1  (EXP,ISO)
ginsenoside Rg2  (ISO)
glafenine  (ISO)
glucose  (ISO)
glutathione  (EXP,ISO)
glutathione disulfide  (ISO)
glyburide  (EXP,ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glycyrrhetinate  (ISO)
glycyrrhetinic acid  (ISO)
glyphosate  (ISO)
Goe 6976  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
guggulsterone  (EXP)
GW 4064  (EXP,ISO)
hepoxilin A3  (EXP)
heptachlor  (ISO)
Heptachlor epoxide  (EXP)
hexadecanoic acid  (ISO)
hydrogen peroxide  (EXP,ISO)
Hypaconitine  (EXP,ISO)
icariside II  (EXP,ISO)
imipenem hydrate  (EXP)
indole-3-methanol  (ISO)
indometacin  (ISO)
inulin  (EXP)
irinotecan  (EXP,ISO)
iron(III) nitrilotriacetate  (EXP)
isoniazide  (ISO)
ivermectin  (EXP)
JTE-013  (ISO)
ketoconazole  (ISO)
kojic acid  (ISO)
KT 5720  (ISO)
L-ascorbic acid  (ISO)
L-cysteine  (ISO)
L-methionine  (EXP,ISO)
leukotriene C4  (ISO)
levetiracetam  (ISO)
lipopolysaccharide  (EXP,ISO)
liquiritin  (EXP)
lithocholic acid  (EXP,ISO)
loperamide  (EXP)
lopinavir  (ISO)
loratadine  (ISO)
lovastatin  (ISO)
luteolin  (EXP)
LY294002  (ISO)
macitentan  (ISO)
manganese(II) chloride  (ISO)
Maprotiline  (ISO)
Meclizine  (EXP)
mercury atom  (EXP,ISO)
mercury dichloride  (EXP,ISO)
mercury(0)  (EXP,ISO)
Mesaconitine  (ISO)
metformin  (ISO)
methapyrilene  (ISO)
methidathion  (EXP)
methotrexate  (EXP,ISO)
methoxsalen  (ISO)
methylarsonic acid  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (EXP,ISO)
metiram  (ISO)
metronidazole  (EXP)
microcystin LF  (ISO)
microcystin RR  (ISO)
microcystin-LR  (EXP,ISO)
Midecamycin  (ISO)
mifepristone  (EXP)
MK 571  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
mono(glucosyluronic acid)bilirubin  (EXP,ISO)
monosodium L-glutamate  (EXP)
montelukast  (ISO)
Muraglitazar  (ISO)
myricetin  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-L-cysteine  (ISO)
N-Acetyl-S-(1,2-dichlorovinyl)-cysteine  (EXP)
N-hydroxy-PhIP  (EXP)
N-nitrosodiethylamine  (ISO)
N-Vinyl-2-pyrrolidone  (ISO)
nelfinavir  (ISO)
neomycin  (EXP)
nifedipine  (ISO)
nimesulide  (ISO)
nitric oxide  (ISO)
nitrofen  (ISO)
nitrogen dioxide  (ISO)
nocodazole  (ISO)
norgestimate  (ISO)
notoginsenoside R1  (ISO)
Nutlin-3  (ISO)
obeticholic acid  (EXP,ISO)
ochratoxin A  (EXP,ISO)
oleanolic acid  (EXP)
olmesartan  (ISO)
oltipraz  (EXP,ISO)
omeprazole  (ISO)
organoselenium compound  (ISO)
orphenadrine  (ISO)
ortho-Aminoazotoluene  (EXP)
oxaliplatin  (ISO)
p-menthan-3-ol  (EXP)
paclitaxel  (EXP,ISO)
pantoprazole  (ISO)
paracetamol  (EXP,ISO)
parathion  (EXP)
paroxetine  (ISO)
PCB138  (EXP)
pentachlorophenol  (EXP)
perfluorobutyric acid  (EXP)
perfluorodecanoic acid  (EXP)
perfluorononanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
perhexiline  (ISO)
phalloidin  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (EXP,ISO)
phenol red  (ISO)
phenytoin  (ISO)
PhIP  (EXP,ISO)
phorbol 13-acetate 12-myristate  (ISO)
physcion  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (ISO)
pitavastatin  (ISO)
pitavastatin(1-)  (ISO)
platinum  (ISO)
platinum(0)  (ISO)
pravastatin  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
probenecid  (ISO)
prochloraz  (ISO)
procymidone  (EXP)
progesterone  (ISO)
propane-1,2-diol  (EXP)
protein kinase inhibitor  (ISO)
prothioconazole  (EXP)
Prothioconazole-desthio  (EXP)
Prulifloxacin  (ISO)
psoralen  (ISO)
pyrazinecarboxamide  (ISO)
pyrrolidines  (ISO)
quercetin  (ISO)
reactive oxygen species  (ISO)
resveratrol  (ISO)
rifampicin  (ISO)
robinetin  (ISO)
rosuvastatin calcium  (ISO)
rotenone  (ISO)
rubitecan  (ISO)
S-(2,4-dinitrophenyl)glutathione  (ISO)
S-nitrosoglutathione  (ISO)
saquinavir  (ISO)
selenium atom  (EXP,ISO)
senecionine  (EXP,ISO)
sevoflurane  (ISO)
simvastatin  (ISO)
sincalide  (ISO)
sirolimus  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (EXP)
sodium dichromate  (EXP,ISO)
sodium dodecyl sulfate  (ISO)
sodium hydrogencarbonate  (ISO)
sodium selenide  (ISO)
sorafenib  (ISO)
soybean oil  (ISO)
spironolactone  (ISO)
stilbene oxide  (ISO)
streptozocin  (EXP,ISO)
succimer  (ISO)
sulfasalazine  (ISO)
sulfinpyrazone  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
Sunset Yellow FCF  (ISO)
tamoxifen  (ISO)
Tanshinone I  (EXP,ISO)
tartrazine  (ISO)
taurine  (ISO)
tauro-beta-muricholic acid  (ISO)
taurochenodeoxycholic acid  (ISO)
taurocholic acid  (EXP,ISO)
taurolithocholic acid  (ISO)
tauroursodeoxycholic acid  (EXP,ISO)
tectorigenin  (EXP)
Temocaprilat  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
texas red  (ISO)
Theaflavin 3,3'-digallate  (ISO)
thiacloprid  (EXP)
thioacetamide  (ISO)
thiophanate-methyl  (EXP)
thyroxine  (ISO)
Thyroxine glucuronide  (ISO)
tiagabine  (ISO)
tianeptine  (ISO)
ticlopidine  (ISO)
titanium dioxide  (ISO)
tolvaptan  (ISO)
topiramate  (ISO)
topotecan  (ISO)
trans-piceid  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
trimethylarsine oxide  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (EXP,ISO)
triptonide  (EXP)
troglitazone  (ISO)
tyrphostin AG 1478  (ISO)
uranium atom  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (EXP,ISO)
vadimezan  (ISO)
valdecoxib  (ISO)
valproic acid  (EXP,ISO)
vancomycin  (EXP,ISO)
verapamil  (ISO)
vincaleukoblastine  (ISO)
vincristine  (ISO)
vitamin E  (ISO)
wortmannin  (ISO)
Y-27632  (ISO)
Yangonin  (EXP)
yohimbine  (EXP)
zearalenone  (ISO)
ziram  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
antibiotic metabolic process  (ISO)
benzylpenicillin metabolic process  (ISO)
bile acid and bile salt transport  (ISO)
bile acid signaling pathway  (ISO)
bilirubin transport  (ISO)
canalicular bile acid transport  (ISO)
cellular response to dexamethasone stimulus  (ISO)
cellular response to interleukin-1  (ISO)
cellular response to interleukin-6  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to tumor necrosis factor  (ISO)
cellular response to xenobiotic stimulus  (ISO)
detoxification of mercury ion  (ISO)
female pregnancy  (ISO)
intracellular chloride ion homeostasis  (ISO)
leukotriene transport  (ISO)
mercury ion transport  (ISO)
negative regulation of gene expression  (ISO)
organic anion transport  (ISO)
prostaglandin transport  (ISO)
regulation of bile acid secretion  (ISO)
response to antineoplastic agent  (ISO)
response to arsenic-containing substance  (ISO)
response to estradiol  (ISO)
response to estrogen  (ISO)
response to glucagon  (ISO)
response to lipopolysaccharide  (ISO)
response to organic cyclic compound  (ISO)
response to oxidative stress  (ISO)
response to steroid hormone  (ISO)
response to xenobiotic stimulus  (ISO)
thyroid hormone transport  (ISO)
transepithelial transport  (ISO)
transmembrane transport  (IBA)
xenobiotic catabolic process  (ISO)
xenobiotic detoxification by transmembrane export across the plasma membrane  (ISO)
xenobiotic export from cell  (ISO)
xenobiotic transmembrane transport  (ISO)
xenobiotic transport across blood-brain barrier  (ISO)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Clinical impact of ABCC1 and ABCC2 genotypes and haplotypes in mediating imatinib resistance among chronic myeloid leukaemia patients. Au A, etal., J Clin Pharm Ther. 2014 Dec;39(6):685-90. doi: 10.1111/jcpt.12197. Epub 2014 Jul 24.
2. Heat stress enhances recovery of hepatocyte bile acid and organic anion transporters in endotoxemic rats by multiple mechanisms. Bolder U, etal., Cell Stress Chaperones. 2006 Spring;11(1):89-100.
3. cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMrp, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats. Buchler M, etal., J Biol Chem 1996 Jun 21;271(25):15091-8.
4. Drug-metabolizing enzyme and transporter expression in a mouse model of diabetes and obesity. Cheng Q, etal., Mol Pharm. 2008 Jan-Feb;5(1):77-91. Epub 2008 Jan 12.
5. MRP2 haplotypes confer differential susceptibility to toxic liver injury. Choi JH, etal., Pharmacogenet Genomics. 2007 Jun;17(6):403-15. doi: 10.1097/01.fpc.0000236337.41799.b3.
6. Estradiol-17beta-D-glucuronide induces endocytic internalization of Bsep in rats. Crocenzi FA, etal., Am J Physiol Gastrointest Liver Physiol. 2003 Aug;285(2):G449-59. Epub 2003 Apr 17.
7. Genetic susceptibility to diclofenac-induced hepatotoxicity: contribution of UGT2B7, CYP2C8, and ABCC2 genotypes. Daly AK, etal., Gastroenterology. 2007 Jan;132(1):272-81. doi: 10.1053/j.gastro.2006.11.023. Epub 2006 Nov 17.
8. Consequences of bile duct obstruction on intestinal expression and function of multidrug resistance-associated protein 2. Dietrich CG, etal., Gastroenterology. 2004 Apr;126(4):1044-53.
9. Characterization of organic anion transporter regulation, glutathione metabolism and bile formation in the obese Zucker rat. Geier A, etal., J Hepatol. 2005 Dec;43(6):1021-30. Epub 2005 Jul 1.
10. Association of ABCC2 polymorphisms with platinum-based chemotherapy response and severe toxicity in non-small cell lung cancer patients. Han B, etal., Lung Cancer. 2011 May;72(2):238-43. doi: 10.1016/j.lungcan.2010.09.001. Epub 2010 Oct 12.
11. Associations of ABCB1, ABCC2, and ABCG2 polymorphisms with irinotecan-pharmacokinetics and clinical outcome in patients with advanced non-small cell lung cancer. Han JY, etal., Cancer. 2007 Jul 1;110(1):138-47.
12. The pharmacokinetics of morphine and its glucuronide conjugate in a rat model of streptozotocin-induced diabetes and the expression of MRP2, MRP3 and UGT2B1 in the liver. Hasegawa Y, etal., J Pharm Pharmacol. 2010 Mar;62(3):310-4. doi: 10.1211/jpp.62.03.0004.
13. Treatment of hyperbilirubinemia in Eisai hyperbilirubinemic rat by transfecting human MRP2/ABCC2 gene. Hirouchi M, etal., Pharm Res. 2005 Apr;22(4):661-6. Epub 2005 Apr 7.
14. Association of the c.3972C>T variant of the multidrug resistance-associated protein 2 Gene (MRP2/ABCC2) with susceptibility to bile duct cancer. Hoblinger A, etal., Digestion. 2009;80(1):36-9. Epub 2009 May 19.
15. Expression of the multidrug transporter MRP2 in the blood-brain barrier after pilocarpine-induced seizures in rats. Hoffmann K, etal., Epilepsy Res. 2006 Apr;69(1):1-14. Epub 2006 Feb 28.
16. Prospective evaluation of the drug-metabolizing enzyme polymorphisms and toxicity profile of docetaxel in Korean patients with operable lymph node-positive breast cancer receiving adjuvant chemotherapy. Kim KP, etal., Cancer Chemother Pharmacol. 2012 May;69(5):1221-7. doi: 10.1007/s00280-011-1816-4. Epub 2012 Jan 20.
17. Differences in the pharmacokinetics of peroxisome proliferator-activated receptor agonists in genetically obese Zucker and sprague-dawley rats: implications of decreased glucuronidation in obese Zucker rats. Kim MS, etal., Drug Metab Dispos. 2004 Sep;32(9):909-14.
18. Polymorphisms in drug transporter genes (ABCB1, SLCO1B1 and ABCC2) and hepatitis induced by antituberculosis drugs. Kim SH, etal., Tuberculosis (Edinb). 2012 Jan;92(1):100-4. doi: 10.1016/j.tube.2011.09.007. Epub 2011 Dec 16.
19. Association of genetic polymorphisms in SLCO1B3 and ABCC2 with docetaxel-induced leukopenia. Kiyotani K, etal., Cancer Sci. 2008 May;99(5):967-72. doi: 10.1111/j.1349-7006.2008.00765.x. Epub 2008 Feb 19.
20. Increased plasma post-heparin diamine oxidase activity and plant sterol levels in streptozotocin diabetic rat. Kojima H, etal., Biochem Biophys Res Commun. 1992 Jul 15;186(1):398-404.
21. The relationship of polymorphisms in ABCC2 and SLCO1B3 with docetaxel pharmacokinetics and neutropenia: CALGB 60805 (Alliance). Lewis LD, etal., Pharmacogenet Genomics. 2013 Jan;23(1):29-33. doi: 10.1097/FPC.0b013e32835b16d8.
22. Role of AMP-activated protein kinase α1 in 17α-ethinylestradiol-induced cholestasis in rats. Li X, etal., Arch Toxicol. 2017 Jan;91(1):481-494. doi: 10.1007/s00204-016-1697-8. Epub 2016 Apr 18.
23. Association of ABCC2 -24C>T polymorphism with high-dose methotrexate plasma concentrations and toxicities in childhood acute lymphoblastic leukemia. Liu Y, etal., PLoS One. 2014 Jan 3;9(1):e82681. doi: 10.1371/journal.pone.0082681. eCollection 2014.
24. Functional induction of P-glycoprotein in the blood-brain barrier of streptozotocin-induced diabetic rats: evidence for the involvement of nuclear factor-kappaB, a nitrosative stress-sensitive transcription factor, in the regulation. Maeng HJ, etal., Drug Metab Dispos. 2007 Nov;35(11):1996-2005. Epub 2007 Jul 30.
25. 4-Hydroxyacetophenone-induced choleresis in rats is mediated by the Mrp2-dependent biliary secretion of its glucuronide conjugate. Mahagita C, etal., Pharm Res. 2006 Nov;23(11):2603-10. Epub 2006 Sep 29.
26. Metabolism and disposition of acetaminophen: recent advances in relation to hepatotoxicity and diagnosis. McGill MR and Jaeschke H, Pharm Res. 2013 Sep;30(9):2174-87. doi: 10.1007/s11095-013-1007-6. Epub 2013 Mar 6.
27. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
28. MGDs mouse GO annotations MGD data from the GO Consortium
29. Down-regulation of intestinal drug transporters in chronic renal failure in rats. Naud J, etal., J Pharmacol Exp Ther. 2007 Mar;320(3):978-85. Epub 2006 Nov 29.
30. Expression of multidrug resistance-associated protein 2 is involved in chemotherapy resistance in human pancreatic cancer. Noma B, etal., Int J Oncol. 2008 Dec;33(6):1187-94.
31. Renal and hepatic transporter expression in type 2 diabetic rats. Nowicki MT, etal., Drug Metab Lett. 2008 Jan;2(1):11-7.
32. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
33. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
34. Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene. Paulusma CC, etal., Science 1996 Feb 23;271(5252):1126-8.
35. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
36. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
37. Magnetic resonance imaging with hepatospecific contrast agents in cirrhotic rat livers. Planchamp C, etal., Invest Radiol. 2005 Apr;40(4):187-94.
38. Multidrug resistance protein MRP2 contributes to blood-brain barrier function and restricts antiepileptic drug activity. Potschka H, etal., J Pharmacol Exp Ther 2003 Jul;306(1):124-31.
39. Mouse MP Annotation Import Pipeline RGD automated import pipeline
40. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
41. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
42. Polymorphisms of MRP2 (ABCC2) are associated with susceptibility to nonalcoholic fatty liver disease. Sookoian S, etal., J Nutr Biochem. 2009 Oct;20(10):765-70. doi: 10.1016/j.jnutbio.2008.07.005. Epub 2008 Oct 15.
43. Doxorubicin pathways: pharmacodynamics and adverse effects. Thorn CF, etal., Pharmacogenet Genomics. 2011 Jul;21(7):440-6. doi: 10.1097/FPC.0b013e32833ffb56.
44. Genomic structure of the canalicular multispecific organic anion-transporter gene (MRP2/cMOAT) and mutations in the ATP-binding-cassette region in Dubin-Johnson syndrome. Toh S, etal., Am J Hum Genet. 1999 Mar;64(3):739-46.
45. Mutations in the canilicular multispecific organic anion transporter (cMOAT) gene, a novel ABC transporter, in patients with hyperbilirubinemia II/Dubin-Johnson syndrome. Wada M, etal., Hum Mol Genet. 1998 Feb;7(2):203-7. doi: 10.1093/hmg/7.2.203.
46. Decreased exposure of simvastatin and simvastatin acid in a rat model of type 2 diabetes. Xu D, etal., Acta Pharmacol Sin. 2014 Sep;35(9):1215-25. doi: 10.1038/aps.2014.39. Epub 2014 Aug 25.
47. Function of multidrug resistance-associated protein 2 in acute hepatic failure rats. Yokooji T, etal., Eur J Pharmacol. 2006 Sep 28;546(1-3):152-60. Epub 2006 Jul 5.
48. Genetic polymorphisms in candidate genes predict increased toxicity with methotrexate therapy in Lebanese children with acute lymphoblastic leukemia. Zgheib NK, etal., Pharmacogenet Genomics. 2014 Aug;24(8):387-96. doi: 10.1097/FPC.0000000000000069.
49. Experimental LPS-induced cholestasis alters subcellular distribution and affects colocalization of Mrp2 and Bsep proteins: a quantitative colocalization study. Zinchuk V, etal., Microsc Res Tech. 2005 Jun 1;67(2):65-70.
50. Alterations of canalicular ATP-binding cassette transporter expression in drug-induced liver injury. Zollner G, etal., Digestion. 2014;90(2):81-8. doi: 10.1159/000365003. Epub 2014 Sep 4.
Additional References at PubMed
PMID:9430713   PMID:9434956   PMID:10087301   PMID:10581366   PMID:10581368   PMID:10602987   PMID:10708515   PMID:10944550   PMID:11004524   PMID:11074014   PMID:11208732   PMID:11279518  
PMID:12068294   PMID:12951053   PMID:12963034   PMID:12967592   PMID:14681479   PMID:15802388   PMID:16361063   PMID:16403838   PMID:16421286   PMID:16426233   PMID:16537972   PMID:16611851  
PMID:16959944   PMID:17273943   PMID:17485564   PMID:17707334   PMID:18180270   PMID:18349876   PMID:19017997   PMID:19088030   PMID:19228692   PMID:19443695   PMID:19996279   PMID:20060011  
PMID:20404332   PMID:20584751   PMID:21305474   PMID:21351274   PMID:21451505   PMID:21674030   PMID:21677750   PMID:21841039   PMID:21873635   PMID:22034653   PMID:22057277   PMID:22232210  
PMID:22914987   PMID:22917771   PMID:23125159   PMID:24039982   PMID:24194600   PMID:24334255   PMID:24641901   PMID:25145654   PMID:25952649   PMID:26416771   PMID:26926046   PMID:27626380  
PMID:27820600   PMID:27834195   PMID:28479363   PMID:29976647   PMID:32753644   PMID:35444014  


Genomics

Comparative Map Data
Abcc2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391943,770,747 - 43,826,771 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1943,770,631 - 43,829,179 (+)EnsemblGRCm39 Ensembl
GRCm381943,782,308 - 43,838,332 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1943,782,192 - 43,840,740 (+)EnsemblGRCm38mm10GRCm38
MGSCv371943,856,798 - 43,912,708 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361943,835,715 - 43,891,248 (+)NCBIMGSCv36mm8
Celera1944,567,463 - 44,621,438 (+)NCBICelera
Cytogenetic Map19C3NCBI
cM Map1936.67NCBI
ABCC2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381099,782,640 - 99,852,594 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1099,782,640 - 99,852,594 (+)EnsemblGRCh38hg38GRCh38
GRCh3710101,542,397 - 101,612,351 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610101,532,493 - 101,601,571 (+)NCBINCBI36Build 36hg18NCBI36
Build 3410101,532,562 - 101,601,571NCBI
Celera1095,279,806 - 95,349,643 (+)NCBICelera
Cytogenetic Map10q24.2NCBI
HuRef1095,169,835 - 95,239,503 (+)NCBIHuRef
CHM1_110101,824,911 - 101,894,368 (+)NCBICHM1_1
T2T-CHM13v2.010100,665,562 - 100,736,331 (+)NCBIT2T-CHM13v2.0
Abcc2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81252,613,875 - 252,672,459 (+)NCBIGRCr8
mRatBN7.21242,664,657 - 242,723,239 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1242,664,657 - 242,723,238 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1250,813,581 - 250,872,198 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01257,510,469 - 257,569,198 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01250,163,726 - 250,222,340 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01263,554,426 - 263,612,556 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1263,554,453 - 263,613,252 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01270,999,832 - 271,057,750 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1238,483,399 - 238,539,595 (+)NCBICelera
Cytogenetic Map1q54NCBI
Abcc2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555075,724,762 - 5,790,812 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555075,724,788 - 5,791,281 (+)NCBIChiLan1.0ChiLan1.0
ABCC2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28111,665,912 - 111,749,129 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110111,688,214 - 111,755,876 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01096,385,534 - 96,458,571 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11099,889,021 - 99,947,452 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1099,889,160 - 99,947,270 (+)Ensemblpanpan1.1panPan2
ABCC2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12812,670,885 - 12,740,124 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2812,670,885 - 12,740,740 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2812,854,192 - 12,923,368 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02813,138,667 - 13,208,016 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2813,138,667 - 13,208,633 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12812,685,440 - 12,754,683 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02812,716,120 - 12,786,599 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02812,857,984 - 12,927,300 (+)NCBIUU_Cfam_GSD_1.0
Abcc2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721334,253,163 - 34,302,933 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936636292,709 - 340,393 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936636292,631 - 341,999 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ABCC2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14110,955,633 - 111,037,537 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114110,955,698 - 111,038,898 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214120,400,787 - 120,484,137 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ABCC2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1992,826,423 - 92,902,389 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl992,841,818 - 92,902,265 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604853,844,985 - 53,909,244 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Abcc2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473711,593,864 - 11,688,460 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473711,593,701 - 11,686,790 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Abcc2
1848 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:475
Count of miRNA genes:371
Interacting mature miRNAs:415
Transcripts:ENSMUST00000026208, ENSMUST00000129943, ENSMUST00000143553, ENSMUST00000146737
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1302019Pgia23_mproteoglycan induced arthritis 23 (mouse)Not determined19978745343787602Mouse
14928311Manh85_mmandible shape 85 (mouse)191191478945914789Mouse
10413881Moe2_mmodifier of epilepsy 2 (mouse)191492301648923138Mouse
1301336Alcp23_malcohol preference locus 23 (mouse)Not determined191591260749912719Mouse
1301633Alcp24_malcohol preference locus 24 (mouse)Not determined191591260749912719Mouse
1302063Eae19_mexperimental allergic encephalomyelitis 19 (mouse)Not determined191829516252295381Mouse
1302004Lfp2_mlong free running period 2 (mouse)Not determined191829516252295381Mouse
4142343Moen2_mmodifier of engrailed QTL 2 (mouse)Not determined192023431454234461Mouse
10412251Mnp_mmodifier of Niemann Pick type C1 (mouse)Not determined192023431454234461Mouse
4141659Pbwg20_mpostnatal body weight growth 20 (mouse)Not determined192137870555378928Mouse
1558876W3q14_mweight 3 weeks QTL 14 (mouse)Not determined192231332653911504Mouse
12790634Ebm1_mEpidermolysis Bullosa modifier 1 (mouse)192498843958988439Mouse
1301451Ath16_matherosclerosis 16 (mouse)Not determined192542691759427005Mouse
13506250Renmq1_mrenal mercury accumulation QTL 1 (mouse)192738559461385705Mouse
4141138Femwf11_mfemur work to failure 11 (mouse)Not determined2814034861420004Mouse
1300683Fembm7_mfemoral bone morphometry 7 (mouse)Not determined193014122461420004Mouse
1301942Pas13_mpulmonary adenoma susceptibility 13 (mouse)Not determined193014123161420004Mouse
1301410Cd8mts6_mCD8 memory T cell subset 6 (mouse)Not determined193014123161420004Mouse
1300856Nobq2_mNew Zealand obese QTL 2 (mouse)Not determined193089788061420004Mouse
1301741Lith2_mlithogenic gene 2 (mouse)Not determined193299215861420004Mouse
1301639Stnn_mstriatal neuron number (mouse)Not determined193395195261420004Mouse
4141019Tgq29_mtriglyceride QTL 29 (mouse)Not determined3459678661420004Mouse
1301479Sluc1_msusceptibility to lung cancer 1 (mouse)Not determined193601694446761521Mouse
1302170Tanidd1_mtally ho associated non-insulin dependednt diabetes mellitus 1 (mouse)Not determined193675259761420004Mouse
13504736Ifvrq6_minfluenza virus resistance QTL 6 (mouse)193690291044913949Mouse
4141650Chldq9_mcholesterol and HDL QTL 9 (mouse)Not determined193788298261420004Mouse
1301466T2dm2_mtype 2 diabetes mellitus 2 (mouse)Not determined193837605061420004Mouse
1302104Lfp1_mlong free running period 1 (mouse)Not determined193918406461420004Mouse
10043896Bw21_mbody weight QTL 21 (mouse)Not determined193959606661420004Mouse
1300585Pgia12_mproteoglycan induced arthritis 12 (mouse)Not determined194258685961420004Mouse

Markers in Region
AI173996  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381943,837,471 - 43,837,557UniSTSGRCm38
MGSCv371943,911,961 - 43,912,047UniSTSGRCm37
Celera1944,620,691 - 44,620,777UniSTS
Cytogenetic Map19C3-D1UniSTS
Cytogenetic Map19C3UniSTS
cM Map1943.0UniSTS
Whitehead/MRC_RH19432.87UniSTS
PMC86435P2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381943,836,680 - 43,837,644UniSTSGRCm38
MGSCv371943,911,170 - 43,912,134UniSTSGRCm37
Celera1944,619,900 - 44,620,864UniSTS
Cytogenetic Map19C3UniSTS
cM Map1943.0UniSTS
Abcc2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381943,837,437 - 43,837,713UniSTSGRCm38
MGSCv371943,911,927 - 43,912,203UniSTSGRCm37
Celera1944,620,657 - 44,620,933UniSTS
Cytogenetic Map19C3UniSTS
Cytogenetic Map19C3-D1UniSTS
cM Map1943.0UniSTS
Abcc1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map16A1UniSTS
Cytogenetic Map19C3UniSTS
cM Map169.75UniSTS


Expression


Sequence