Chrm4 (cholinergic receptor, muscarinic 4)

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Gene: Chrm4 (cholinergic receptor, muscarinic 4) Mus musculus

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Symbol:

Chrm4

Name:

cholinergic receptor, muscarinic 4

RGD ID:

10353

MGI Page

MGI

Description:

Enables G protein-coupled acetylcholine receptor activity. Acts upstream of or within adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway. Located in membrane. Is expressed in several structures, including alimentary system; eye; limb; nervous system; and reproductive system. Orthologous to human CHRM4 (cholinergic receptor muscarinic 4).

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

AChR M4; Chrm-; Chrm-4; M4; mm4 mAChR; muscarinic acetylcholine receptor 4; muscarinic acetylcholine receptor M4

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CHRM4 (cholinergic receptor muscarinic 4)	HGNC	EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB
Rattus norvegicus (Norway rat):	Chrm4 (cholinergic receptor, muscarinic 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Chrm4 (cholinergic receptor muscarinic 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	CHRM4 (cholinergic receptor muscarinic 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	CHRM4 (cholinergic receptor muscarinic 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Chrm4 (cholinergic receptor muscarinic 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	CHRM4 (cholinergic receptor muscarinic 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	CHRM4 (cholinergic receptor muscarinic 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Chrm4 (cholinergic receptor muscarinic 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Rattus norvegicus (Norway rat):	Chrm4 (cholinergic receptor, muscarinic 4)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	CHRM4 (cholinergic receptor muscarinic 4)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	chrm4a (cholinergic receptor, muscarinic 4a)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid\|ZFIN)
Caenorhabditis elegans (roundworm):	gar-3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	mAChR-A	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	chrm4b	Alliance	DIOPT (PANTHER\|PhylomeDB\|ZFIN)

Latest Assembly:

GRCm39 - Mouse Genome Assembly GRCm39

Position:

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	91,752,531 - 91,760,180 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	91,757,594 - 91,759,033 (+)	Ensembl		GRCm39 Ensembl
GRCm38	2	91,922,189 - 91,929,835 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	91,927,249 - 91,928,688 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	91,762,346 - 91,769,986 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	91,728,088 - 91,729,527 (+)	NCBI		MGSCv36	mm8
Celera	2	93,312,590 - 93,320,231 (+)	NCBI		Celera
Cytogenetic Map	2	E1	NCBI
cM Map	2	50.63	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Catatonia (ISO)

congenital disorder of glycosylation type IIc (ISO)

congestive heart failure (ISO)

Developmental Disabilities (ISO)

intellectual disability (ISO)

Tremor (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-pilocarpine (ISO)

(+)-trans-(S)-allethrin (EXP)

1,2-dimethylhydrazine (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,3,7,8-Tetrachlorodibenzofuran (ISO)

3,4-methylenedioxymethamphetamine (EXP)

acetylcholine (ISO)

aflatoxin B1 (ISO)

alcuronium (ISO)

alpha-Zearalanol (ISO)

ammonium chloride (ISO)

arsenite(3-) (EXP)

atropine (ISO)

Azoxymethane (EXP)

benzo[a]pyrene (ISO)

bethanechol (ISO)

bisphenol A (EXP,ISO)

brucine (ISO)

C60 fullerene (ISO)

cadmium atom (ISO)

cadmium dichloride (EXP,ISO)

carbachol (ISO)

carmustine (ISO)

CGP 52608 (ISO)

chlorohydrocarbon (ISO)

chlorpyrifos (ISO)

cisplatin (ISO)

cocaine (ISO)

Cuprizon (ISO)

DDT (EXP)

dexamethasone (EXP)

dextran sulfate (EXP)

diazinon (ISO)

dieldrin (ISO)

Eburnamonine (ISO)

ethanol (EXP)

folic acid (EXP)

furtrethonium (ISO)

haloperidol (EXP)

Licochalcone B (ISO)

lipopolysaccharide (ISO)

methoctramine tetrahydrochloride (ISO)

methscopolamine (ISO)

mevinphos (ISO)

N-acetyl-L-cysteine (EXP)

nickel atom (ISO)

oxotremorine M (ISO)

pancuronium (ISO)

paracetamol (ISO)

parathion-methyl (ISO)

perfluorooctanoic acid (ISO)

Pipecuronium (ISO)

quercetin (ISO)

resveratrol (ISO)

risperidone (EXP)

rocuronium (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

scopolamine (EXP)

silicon dioxide (ISO)

sotorasib (ISO)

sparteine (ISO)

strychnine (ISO)

sunitinib (ISO)

tetrachloromethane (EXP,ISO)

tiotropium bromide (ISO)

titanium dioxide (EXP)

trametinib (ISO)

trichlorfon (ISO)

trichloroethene (ISO)

trichostatin A (ISO)

triptonide (EXP)

tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate (ISO)

Tropicamide (ISO)

valproic acid (ISO)

vecuronium bromide (ISO)

wogonin (EXP)

xanomeline (EXP,ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway (IBA,IDA)

chemical synaptic transmission (IBA)

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger (IBA)

regulation of locomotion (IEA)

Cellular Component

asymmetric synapse (ISO)

axon terminus (ISO)

dendrite (IBA)

glutamatergic synapse (ISO)

membrane (IDA)

neuronal cell body (ISO)

plasma membrane (IBA)

postsynaptic density membrane (ISO)

postsynaptic membrane (IEA)

presynaptic membrane (ISO)

sarcolemma (ISO)

synapse (IBA)

Molecular Function

G protein-coupled acetylcholine receptor activity (IBA,IDA)

guanyl-nucleotide exchange factor activity (ISO)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

acetylcholine signaling pathway via muscarinic acetylcholine receptors engaging G alphai protein family (ISO)

G protein mediated signaling pathway via Galphai family (ISO)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal behavioral response to xenobiotic (IAGP)

abnormal brain wave pattern (IAGP)

abnormal CNS synaptic transmission (IAGP)

abnormal gallbladder physiology (IAGP)

abnormal heart rate (IAGP)

abnormal locomotor behavior (IAGP)

abnormal neuron physiology (IAGP)

abnormal vocalization (IAGP)

catalepsy (IAGP)

decreased body weight (IAGP)

decreased synaptic depression (IAGP)

enhanced behavioral response to addictive substance (IAGP)

enhanced behavioral response to cocaine (IAGP)

enhanced behavioral response to xenobiotic (IAGP)

hyperactivity (IAGP)

impaired behavioral response to xenobiotic (IAGP)

impaired smooth muscle contractility (IAGP)

increased dopamine level (IAGP)

increased locomotor activity (IAGP)

increased startle reflex (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Regulation of neuronal type genes in congestive heart failure rats.	Andersson KB, etal., Acta Physiol (Oxf). 2006 Jan;186(1):17-27.
2.	Electronic Transfer of Homolog Data	MGD and Homologene mouse data transfer
3.	MGDs mouse GO annotations	MGD data from the GO Consortium
4.	MGD IEA	MGD IEA
5.	Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.	Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
6.	Mouse MP Annotation Import Pipeline	RGD automated import pipeline
7.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
9.	Muscarinic signaling in the brain.	Thiele A Annu Rev Neurosci. 2013 Jul 8;36:271-94. doi: 10.1146/annurev-neuro-062012-170433.

Additional References at PubMed

PMID:7648406	PMID:7874308	PMID:7916637	PMID:8020490	PMID:8643689	PMID:8827451	PMID:8921396	PMID:10468635	PMID:10485923	PMID:10549128	PMID:10688600	PMID:11392613
PMID:11880500	PMID:11961069	PMID:12045234	PMID:12118100	PMID:12151512	PMID:12235238	PMID:12391271	PMID:12477932	PMID:12628458	PMID:12675128	PMID:12729838	PMID:12874603
PMID:14586460	PMID:14610273	PMID:14681479	PMID:15147302	PMID:15231726	PMID:15263021	PMID:15574798	PMID:15661360	PMID:15913791	PMID:15919709	PMID:15922076	PMID:15965496
PMID:16110248	PMID:16365281	PMID:16602821	PMID:17008557	PMID:17878406	PMID:18199763	PMID:18206430	PMID:18382674	PMID:18550768	PMID:18755247	PMID:18799693	PMID:19213795
PMID:19478075	PMID:19940190	PMID:20147565	PMID:20197056	PMID:20203199	PMID:20461055	PMID:20463237	PMID:20600670	PMID:20940295	PMID:21114972	PMID:21373792	PMID:21873635
PMID:22123412	PMID:22302687	PMID:22463818	PMID:22956788	PMID:23907402	PMID:24194600	PMID:24351932	PMID:24528004	PMID:24695732	PMID:24807965	PMID:24952961	PMID:25445043
PMID:26080439	PMID:26084221	PMID:26508634	PMID:26511239	PMID:26590347	PMID:27223629	PMID:27339059	PMID:27452460	PMID:27568567	PMID:27581457	PMID:27618677	PMID:28442355
PMID:29268098	PMID:29401598	PMID:29740282	PMID:29978954	PMID:30914695	PMID:31554738	PMID:31914675	PMID:32170006	PMID:32265261	PMID:32344038	PMID:32409918	PMID:32554809
PMID:34321999	PMID:35314320	PMID:35427599	PMID:36265442	PMID:37172825	PMID:38355793

Genomics

Comparative Map Data

Chrm4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	91,752,531 - 91,760,180 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	91,757,594 - 91,759,033 (+)	Ensembl		GRCm39 Ensembl
GRCm38	2	91,922,189 - 91,929,835 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	91,927,249 - 91,928,688 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	91,762,346 - 91,769,986 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	91,728,088 - 91,729,527 (+)	NCBI		MGSCv36	mm8
Celera	2	93,312,590 - 93,320,231 (+)	NCBI		Celera
Cytogenetic Map	2	E1	NCBI
cM Map	2	50.63	NCBI

CHRM4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	46,383,789 - 46,391,776 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	46,383,789 - 46,391,776 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	11	46,405,339 - 46,413,326 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	46,363,216 - 46,364,683 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	11	46,363,215 - 46,364,683	NCBI
Celera	11	46,554,217 - 46,555,684 (-)	NCBI		Celera
Cytogenetic Map	11	p11.2	NCBI
HuRef	11	46,113,598 - 46,115,064 (-)	NCBI		HuRef
CHM1_1	11	46,405,093 - 46,406,560 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	11	46,539,864 - 46,547,851 (-)	NCBI		T2T-CHM13v2.0

Chrm4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	98,349,080 - 98,356,821 (+)	NCBI		GRCr8
mRatBN7.2	3	77,893,425 - 77,901,166 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	77,893,425 - 77,901,159 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	81,368,613 - 81,376,348 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	89,967,641 - 89,975,378 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	87,818,870 - 87,826,600 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	80,833,272 - 80,841,165 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	80,833,272 - 80,841,006 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	87,531,619 - 87,539,681 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	76,301,988 - 76,309,729 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	76,203,520 - 76,206,094 (+)	NCBI
Celera	3	77,096,073 - 77,103,815 (+)	NCBI		Celera
Cytogenetic Map	3	q24	NCBI

Chrm4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955422	1,647,663 - 1,655,363 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955422	1,647,663 - 1,655,363 (+)	NCBI	ChiLan1.0	ChiLan1.0

CHRM4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	9	48,596,916 - 48,606,737 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	11	48,603,743 - 48,611,729 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	11	46,342,384 - 46,350,366 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	11	46,893,292 - 46,901,074 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	46,894,615 - 46,896,054 (-)	Ensembl	panpan1.1		panPan2

CHRM4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	18	43,077,115 - 43,084,298 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	18	43,082,404 - 43,083,840 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	18	41,805,766 - 41,813,475 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	18	43,733,324 - 43,740,846 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	18	43,733,289 - 43,741,042 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	18	43,218,330 - 43,226,035 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	18	42,770,212 - 42,777,904 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	18	43,503,419 - 43,510,935 (+)	NCBI		UU_Cfam_GSD_1.0

Chrm4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	20,567,540 - 20,576,257 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936562	2,493,774 - 2,689,731 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936562	2,685,209 - 2,687,751 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CHRM4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	16,122,704 - 16,130,810 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	16,119,794 - 16,131,080 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	17,468,644 - 17,476,868 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CHRM4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	18,937,455 - 18,945,390 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	1	18,942,643 - 18,944,079 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666038	116,222,834 - 116,230,831 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Chrm4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624767	2,162,712 - 2,171,012 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624767	2,162,719 - 2,170,921 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	724
Count of miRNA genes:	426
Interacting mature miRNAs:	514
Transcripts:	ENSMUST00000045537, ENSMUST00000170432
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCm39)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
11038697	Ltpr2d_m	Leishmania tropica response 2d (mouse)					2	86095716	120095823	Mouse
11038698	Ltpr2c_m	Leishmania tropica response 2c (mouse)					2	86095716	120095823	Mouse
39128209	Lwq14_m	liver weight QTL 14 (mouse)					2	20897778	118894840	Mouse
1558738	W6q1_m	weight 6 weeks QTL 1 (mouse)			Not determined		2	20897778	118894840	Mouse
13824983	Vclq1_m	curvilinear velocity QTL 1 (mouse)					2	61830344	136841920	Mouse
11528549	Sluc31_m	susceptibility to lung cancer 31 (mouse)					2	74524117	129213005	Mouse
4141236	Hbnr5_m	Heligmosomoides bakeri nematode resistance 5 (mouse)			Not determined			31214567	105143570	Mouse
1302174	Dssc2_m	dextran sodium sulfate induced colitis QTL2 (mouse)			Not determined		2	24224632	148700377	Mouse
1301405	Etohr_m	ethanol response acute (mouse)			Not determined		2	63005954	97006113	Mouse
1301660	Iba1_m	induction of brown adipocytes 1 (mouse)			Not determined		2	67647887	101648142	Mouse
1558915	W3q1_m	weight 3 weeks QTL 1 (mouse)			Not determined		2	20897778	118894840	Mouse
1301703	Bomd3_m	bone mineral density 3 (mouse)			Not determined		2	63005954	97006113	Mouse
11532731	Sluc31a_m	susceptibility to lung cancer 31a (mouse)					2	88015003	122015170	Mouse
1301834	Bits1_m	bitterness sensitivity 1 (mouse)			Not determined		2	87440643	121440778	Mouse
1301769	Orgwq2_m	organ weight QTL 2 (mouse)			Not determined		2	3887126	93421651	Mouse
1357454	Kidq1_m	kidney weight QTL 1 (mouse)			Not determined		2	20897778	118894840	Mouse
4141155	Plast2b_m	plasma plant sterol 2b (mouse)			Not determined		2	84013198	148522175	Mouse
1357577	Trmq3_m	T cell ratio modifier QTL 3 (mouse)			Not determined		2	60520612	119355518	Mouse
1558966	W10q9_m	weight 10 weeks QTL 9 (mouse)			Not determined		2	20897778	118894840	Mouse
4141854	T2dm2sa_m	type 2 diabetes mellitus 2 in SMXA RI mice (mouse)			Not determined		2	29307947	148374934	Mouse
1301873	Hsl1_m	hyperoxia susceptibility locus 1 (mouse)			Not determined		2	63570154	97570301	Mouse
1558901	Skmw8_m	skeletal muscle weight 8 (mouse)			Not determined		2	84008488	118008593	Mouse
1558899	Egq1_m	early growth QTL 1 (mouse)			Not determined		2	20897778	118894840	Mouse
1357681	Hrtq1_m	heart weight QTL 1 (mouse)			Not determined		2	20897778	118894840	Mouse
1300662	Etohila_m	ethanol induced locomotor activity (mouse)			Not determined		2	63005954	97006113	Mouse
1301109	Dntcs2_m	dental caries susceptibility 2 (mouse)			Not determined		2	40885493	114910165	Mouse
4141657	Mohg1_m	modifier of hg 1 (mouse)			Not determined		2	76678758	103095823	Mouse
1300852	Lmr14_m	leishmaniasis resistance 14 (mouse)			Not determined		2	86095716	120095823	Mouse
1357436	Splq1_m	spleen weight QTL 1 (mouse)			Not determined		2	20897778	118894840	Mouse
10053681	Lith24_m	lithogenic gene 24 (mouse)			Not determined		2	63005954	97006113	Mouse
1301882	Etohc2_m	ethanol consumption 2 (mouse)			Not determined		2	68724269	102724407	Mouse
1301048	Actre2_m	activity response to ethanol 2 (mouse)			Not determined		2	63005954	97006113	Mouse
10412082	Hylaq1_m	Hyperlocomotor activity related QTL 1 (mouse)			Not determined		2	84013198	148667470	Mouse
1357881	Estoq1_m	embryo survival total QTL 1 (mouse)			Not determined		2	20897778	118894840	Mouse
1301374	Cplaq7_m	circadian period of locomotor activity 7 (mouse)			Not determined		2	76421483	110421651	Mouse
5491197	Mobq5_m	multigenic obesity QTL 5 (mouse)			Not determined		2	65269746	162518926	Mouse
1301948	Elsgp3_m	elevated serum gp70 3 (mouse)			Not determined		2	68724269	102724407	Mouse
10043894	Bw22_m	body weight QTL 22 (mouse)			Not determined		2	80895334	114895334	Mouse
5491196	Mobq6_m	multigenic obesity QTL 6 (mouse)			Not determined		2	85724269	180896594	Mouse
15092054	Egrme5_m	early growth rate, maternal effect 5 (mouse)					2	82190187	118004745	Mouse
4142223	Femwf4_m	femur work to failure 4 (mouse)			Not determined			88143423	122143570	Mouse
1301344	Lith1_m	lithogenic gene 1 (mouse)			Not determined		2	45347635	145312647	Mouse
11049565	Lmr28g_m	leishmaniasis resistance 28g (mouse)					2	86095716	120095823	Mouse
13463482	Mchq17_m	mean corpuscular hemoglobin QTL 17 (mouse)					2	67647887	101648142	Mouse
4142088	Parms1_m	patched associated RMS 1 (mouse)			Not determined			74524117	114123532	Mouse
1301098	Cd8mts3_m	CD8 memory T cell subset 3 (mouse)			Not determined		2	91089974	125090104	Mouse
10044002	Hdl7_m	HDL level 7 (mouse)			Not determined		2	63005954	97006113	Mouse
12738429	Lfibq18_m	liver fibrosis QTL 18 (mouse)					2	57919991	91919991	Mouse

Markers in Region

Chrm4

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	2	91,927,634 - 91,928,732	UniSTS	GRCm38
MGSCv37	2	91,767,791 - 91,768,889	UniSTS	GRCm37
Celera	2	93,318,035 - 93,319,133	UniSTS
Cytogenetic Map	2	E1	UniSTS
cM Map	2	53.0	UniSTS
cM Map	2	49.0	UniSTS
cM Map	2	53.0	UniSTS
cM Map	2	49.0	UniSTS

UniSTS:481077

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	2	91,927,249 - 91,928,688	UniSTS	GRCm38
MGSCv37	2	91,767,406 - 91,768,845	UniSTS	GRCm37
Celera	2	93,317,650 - 93,319,089	UniSTS
Cytogenetic Map	2	E1	UniSTS
cM Map	2	49.0	UniSTS

UniSTS:492564

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	2	91,927,218 - 91,928,777	UniSTS	GRCm38
MGSCv37	2	91,767,375 - 91,768,934	UniSTS	GRCm37
Celera	2	93,317,619 - 93,319,178	UniSTS
Cytogenetic Map	2	E1	UniSTS
cM Map	2	49.0	UniSTS

Chrm4

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	2	91,928,665 - 91,929,877	UniSTS	GRCm38
MGSCv37	2	91,768,822 - 91,770,034	UniSTS	GRCm37
Celera	2	93,319,066 - 93,320,279	UniSTS
Cytogenetic Map	2	E1	UniSTS
cM Map	2	49.0	UniSTS
cM Map	2	53.0	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001416938	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_007699	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AL731772	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC120504	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC137677	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BY250825	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BY652985	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH466519	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CX122754	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CX241098	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	S74916	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X63473	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSMUST00000045537 ⟹ ENSMUSP00000040808

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	2	91,757,594 - 91,759,033 (+)	Ensembl
GRCm38.p6 Ensembl	2	91,927,249 - 91,928,688 (+)	Ensembl

RefSeq Acc Id:

NM_001416938 ⟹ NP_001403867

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	2	91,752,531 - 91,760,180 (+)	NCBI

RefSeq Acc Id:

NM_007699 ⟹ NP_031725

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	2	91,752,531 - 91,760,180 (+)	NCBI
GRCm38	2	91,922,189 - 91,929,829 (+)	NCBI
MGSCv37	2	91,762,346 - 91,769,986 (+)	RGD
Celera	2	93,312,590 - 93,320,231 (+)	RGD
cM Map	2		ENTREZGENE

Sequence:

show sequence

ACAGCGCCGGGAGCTGCAGGCGAAGCAGGGGCCGCCCCTTGGCACCCTGTCCCCGCCCCCGGCC
CCCGGCCCAGTCGCCCACCCCACCGACTCGCAGGGCCTCTGGCTAGTTCCGCCGTCTGTCCGGC
GCCAGCGGAGCAAGACAGAAGCAGCGGCCACTGCCCACCTGTCTCCAGTTGGGTTCAGCATGGC
GAACTTCACACCTGTCAATGGCAGCTCAGCCAATCAGTCTGTGCGCCTGGTCACAACAGCCCAC
AACCACCTGGAGACAGTGGAGATGGTGTTCATTGCGACAGTGACTGGTTCCCTGAGCCTGGTGA
CTGTGGTGGGTAACATCCTGGTGATGCTGTCCATCAAGGTCAACAGGCAGTTGCAGACAGTCAA
CAACTACTTCCTGTTCAGCCTGGCGTGTGCAGATCTCATCATAGGGGCGTTCTCTATGAACCTT
TACACCTTATACATCATCAAGGGCTACTGGCCCCTGGGTGCCGTGGTCTGTGACCTGTGGCTGG
CCCTGGACTATGTGGTGAGCAATGCCTCTGTCATGAACCTTCTCATCATCAGCTTTGACCGCTA
TTTCTGCGTCACCAAGCCCCTCACCTATCCAGCCCGCCGCACTACTAAGATGGCAGGCCTCATG
ATTGCAGCCGCCTGGGTCTTGTCCTTTGTACTCTGGGCCCCTGCCATCTTGTTCTGGCAGTTTG
TGGTGGGCAAGAGGACAGTGCCTGATAACCAGTGCTTCATCCAGTTCTTGTCCAACCCGGCGGT
GACCTTCGGCACAGCCATTGCTGCCTTCTACCTGCCTGTGGTCATCATGACGGTGCTGTATATT
CATATCTCGCTGGCCAGCCGCAGCCGTGTTCACAAGCATCGACCCGAGGGCCCCAAGGAGAAGA
AGGCCAAGACTCTGGCTTTCCTCAAGAGCCCTCTGATGAAGCCGAGCATTAAGAAACCTCCACC
AGGGGGCGCTTCTCGAGAGGAACTGCGCAACGGGAAGCTAGAAGAGGCTCCTCCGCCAGCCCTG
CCCCCGCCTCCACGCCCAGTGGCTGACAAGGACACTTCCAATGAGTCCAGCTCAGGCAGTGCCA
CCCAGAACACCAAGGAACGGCCACCCACAGAGCTGTCCACCACAGAGGCCGCCACCACACCAGC
GCTGCCCGCTCCTACCCTGCAGCCACGAACCCTCAACCCAGCCTCCAAGTGGTCCAAGATCCAA
ATTGTGACAAAGCAGACAGGCAGTGAATGTGTGACTGCCATCGAGATCGTACCTGCCACGCCAG
CTGGTATGCGCCCAGCAGCCAATGTGGCCCGAAAGTTTGCCAGCATCGCTCGTAACCAGGTGCG
CAAGAAGCGGCAGATGGCGGCCCGGGAGCGCAAAGTGACTCGGACAATCTTTGCCATTCTGCTG
GCCTTCATCCTCACCTGGACACCCTACAATGTCATGGTCCTGGTGAACACCTTTTGCCAGAGCT
GTATCCCCGAAAGGGTGTGGTCCATCGGCTACTGGCTCTGCTACGTCAACAGCACGATCAACCC
TGCCTGCTATGCACTCTGCAATGCCACTTTCAAAAAGACCTTCCGGCACCTTTTGCTGTGCCAG
TATCGGAACATCGGCACAGCCAGGTAGACGGGCAGGTGCCTTAGGAGGTGCTGGTGTCAAGAGT
GTGTACCGGGGAACCACATGGCTCACCGGCTGTGGAGGAGAGAGTAGGCGGCCCCACTCTGAGT
TCGCATCTGCTGAAGAGAACAGGTCTCCCAGACACCGTGAGGTACAAGAGGCTCTTCGCTGGGA
TGGGAGAGCAGATCTCTACTGAAGCCTAGGAGGCTCGGCCCAGGGACGGTCTGAACTGGCACCA
CCTGGCCCATATCTTTTACCTTGCCTCAGGAAGATGGGGGACGATGGCTGGAGTGGGCAGTGGC
TCTATCAAGGCCAACCATCGGTGGAGGTGGATGAATAGAGCAGAACTTGGGAGCATCTTGAGAG
GAGCAAAAGGAGCCAGGCTTGCAAGGGTGGGGTCCCCCGTTATGCTGTAATCGGTGCTTTCCGC
CTTCCTGCGCCCTCCTCTCCCTTGCATGTAGGCTCAGCCCTTCCCCTGCCCCCAAGTCCCACTC
CAAGGTGAGGGACTTCCCTGCCACTGTTGCTCAGCCAGGCTCTGGATGGGAAGCCAAGCCCTTT
GGCACTCCCCTGGCCAGCAGTCATCTGGACAGGGCAACTGGGAGGCCATGCTAAGCCGAGATAC
AGACTCCAGGGGACTGAATCAATTAATGGTGGATCTTATTGTCAAATTGTCAAGAACCCCCCCC
CCCAGGTCACACATCAAATGAACAGCAGTGGGCAGTGTTCCTCTCTACCTCTGAGCGGAGGGAG
GTATGGGTCCAAGGAGGGAAAGGTGATGGTGGGGAACTTGGTGATCCATACAGCCCACAGTGGC
GAATGACACAAGCAAGCACCCTCATGGATCCCCAATGAGAAAATTCCAGACTTGCAGTAGCCTG
GACCAGAAACTCTTGATGAGCTGGGACAGAGTTCAAGTGAGTCACCTAGGTCCCCTTCCCTAAC
CCCAGCCCTGTGGGTCCCTGGGAGACTTTTTTTTTTTTTTTTTTTTTTTTTGTAAATGTTCTGC
TCTTTTTCCACGAGCTGTAGGGAGCACTTCCTTCATAGCCCTCAGCTCCCCTCAGTCCATCTTT
CCCCATCTTCCCACCTCCGACAGAGCTCCATGGCAAACTGGGAAGGGGCTTTTATATATTAAAA
AAGAAGCTTTTATTGG

hide sequence

Protein Sequences


Protein RefSeqs	NP_001403867	(Get FASTA)	NCBI Sequence Viewer
	NP_031725	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAB33577	(Get FASTA)	NCBI Sequence Viewer
	AAI20505	(Get FASTA)	NCBI Sequence Viewer
	AAI37678	(Get FASTA)	NCBI Sequence Viewer
	CAA45071	(Get FASTA)	NCBI Sequence Viewer
	EDL27579	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSMUSP00000040808
	ENSMUSP00000040808.4
GenBank Protein	P32211	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_031725 ⟸ NM_007699

- UniProtKB:

Q64056 (UniProtKB/Swiss-Prot), P32211 (UniProtKB/Swiss-Prot), Q0VBU3 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MANFTPVNGSSANQSVRLVTTAHNHLETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQT
VNNYFLFSLACADLIIGAFSMNLYTLYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFD
RYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQFLSNP
AVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKTLAFLKSPLMKPSIKKP
PPGGASREELRNGKLEEAPPPALPPPPRPVADKDTSNESSSGSATQNTKERPPTELSTTEAATT
PALPAPTLQPRTLNPASKWSKIQIVTKQTGSECVTAIEIVPATPAGMRPAANVARKFASIARNQ
VRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSCIPERVWSIGYWLCYVNSTI
NPACYALCNATFKKTFRHLLLCQYRNIGTAR

hide sequence

Ensembl Acc Id:

ENSMUSP00000040808 ⟸ ENSMUST00000045537

RefSeq Acc Id:	NP_001403867 ⟸ NM_001416938
- UniProtKB:	P32211 (UniProtKB/Swiss-Prot), Q64056 (UniProtKB/Swiss-Prot), Q0VBU3 (UniProtKB/TrEMBL)

Protein Domains

G-protein coupled receptors family 1 profile

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P32211-F1-model_v2	AlphaFold	P32211	1-479	view protein structure

Promoters

RGD ID:

6831033

Promoter ID:

MM_KWN:30510

Type:

CpG-Island

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

BoneMarrow_0Hour, BoneMarrow_2Hour, Brain, Kidney

Transcripts:

NM_007699

Position:

Mouse Assembly	Chr	Position (strand)	Source
MGSCv36	2	91,761,561 - 91,762,222 (+)	MPROMDB

RGD ID:

6831034

Promoter ID:

MM_KWN:30511

Type:

CpG-Island

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

BoneMarrow_0Hour, BoneMarrow_4Hour, Brain, Lung

Transcripts:

OTTMUST00000033987

Position:

Mouse Assembly	Chr	Position (strand)	Source
MGSCv36	2	91,766,871 - 91,768,742 (+)	MPROMDB

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	MGI:88399	AgrOrtholog
Ensembl Genes	ENSMUSG00000040495	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSMUST00000045537	ENTREZGENE
	ENSMUST00000045537.4	UniProtKB/Swiss-Prot
Gene3D-CATH	Rhodopsin 7-helix transmembrane proteins	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	GPCR_Rhodpsn	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GPCR_Rhodpsn_7TM	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Musac_Ach_M4_rcpt	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Musac_Ach_rcpt	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	mmu:12672	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD	MGI:88399	ENTREZGENE
NCBI Gene	12672	ENTREZGENE
PANTHER	5-HYDROXYTRYPTAMINE RECEPTOR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	MUSCARINIC ACETYLCHOLINE RECEPTOR M4	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	7tm_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB	CHRM4	RGD
PhenoGen	Chrm4	PhenoGen
PRINTS	GPCRRHODOPSN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	MUSCARINICR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	MUSCRINICM4R	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	G_PROTEIN_RECEP_F1_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	G_PROTEIN_RECEP_F1_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART	7TM_GPCR_Srsx	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	Family A G protein-coupled receptor-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	ACM4_MOUSE	UniProtKB/Swiss-Prot, ENTREZGENE
	Q0VBU3	ENTREZGENE, UniProtKB/TrEMBL
	Q64056	ENTREZGENE
UniProt Secondary	Q64056	UniProtKB/Swiss-Prot

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

Mammalian Phenotype

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

Mammalian Phenotype