Cd28 (CD28 antigen) - Rat Genome Database

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Gene: Cd28 (CD28 antigen) Mus musculus
Analyze
Symbol: Cd28
Name: CD28 antigen
RGD ID: 10307
MGI Page MGI
Description: Enables protein kinase binding activity. Acts upstream of or within several processes, including positive regulation of immune response; positive regulation of macromolecule biosynthetic process; and regulation of lymphocyte activation. Located in external side of plasma membrane and immunological synapse. Human ortholog(s) of this gene implicated in immunodeficiency 123; multiple sclerosis; and type 1 diabetes mellitus. Orthologous to human CD28 (CD28 molecule).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: T-cell-specific surface glycoprotein CD28
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39160,785,547 - 60,812,521 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl160,755,959 - 60,812,518 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38160,746,388 - 60,773,359 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl160,716,800 - 60,773,359 (+)Ensemblmm10GRCm38
MGSCv37160,803,232 - 60,830,203 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36160,691,012 - 60,717,905 (+)NCBIMGSCv36mm8
Celera161,261,669 - 61,288,639 (+)NCBICelera
Cytogenetic Map1C2NCBI
cM Map130.52NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-aminoethoxydiphenylborane  (ISO)
3,7-dihydropurine-6-thione  (ISO)
acetohydrazide  (EXP)
acrolein  (EXP)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucosamine  (ISO)
alpha-Zearalanol  (ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
Azoxymethane  (EXP)
benzo[a]pyrene  (EXP,ISO)
beta-D-glucosamine  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
buta-1,3-diene  (EXP)
calcidiol  (ISO)
calcitriol  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
carbon nanotube  (EXP)
carboxy-PTIO  (ISO)
chloroprene  (EXP)
cyclophosphamide  (EXP)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
diclofenac  (EXP)
diethylstilbestrol  (EXP)
Diisodecyl phthalate  (EXP)
dimethylarsinic acid  (EXP)
dioxygen  (EXP)
diquat  (EXP)
endosulfan  (ISO)
fenvalerate  (ISO)
fingolimod hydrochloride  (ISO)
fulvestrant  (ISO)
gentamycin  (ISO)
hydrazine  (EXP)
ketoconazole  (ISO)
lipopolysaccharide  (ISO)
magnesium dichloride  (ISO)
manganese(II) chloride  (ISO)
mercaptopurine  (ISO)
mercury dichloride  (EXP)
methotrexate  (ISO)
methylarsonic acid  (EXP)
mifepristone  (ISO)
nickel atom  (ISO)
nitric oxide  (ISO)
ozone  (EXP)
paracetamol  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (EXP)
pravastatin  (EXP,ISO)
purine-6-thiol  (ISO)
reactive oxygen species  (ISO)
rimexolone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
silicon dioxide  (EXP)
silver(1+) nitrate  (EXP)
sodium arsenate  (EXP)
sodium arsenite  (EXP)
sodium aurothiomalate  (EXP)
staurosporine  (ISO)
tebuconazole  (ISO)
thimerosal  (EXP)
titanium dioxide  (EXP)
trichloroethene  (ISO)
trimellitic anhydride  (EXP)
triphenyl phosphate  (ISO)
zaragozic acid A  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal CD4-positive, alpha-beta T cell physiology  (IAGP)
abnormal CD8-positive, alpha beta T cell morphology  (IAGP)
abnormal class switch recombination  (IAGP)
abnormal cytokine secretion  (IAGP)
abnormal cytotoxic T cell physiology  (IAGP)
abnormal esophageal epithelium morphology  (IAGP)
abnormal eyelid morphology  (IAGP)
abnormal germinal center B cell physiology  (IAGP)
abnormal immunoglobulin level  (IAGP)
abnormal interferon level  (IAGP)
abnormal interleukin secretion  (IAGP)
abnormal lymphopoiesis  (IAGP)
abnormal NK cell physiology  (IAGP)
abnormal regulatory T cell physiology  (IAGP)
abnormal response to transplant  (IAGP)
abnormal T cell activation  (IAGP)
abnormal T cell anergy  (IAGP)
abnormal T cell clonal deletion  (IAGP)
abnormal T cell differentiation  (IAGP)
abnormal T cell proliferation  (IAGP)
abnormal T-helper 1 physiology  (IAGP)
abnormal T-helper 2 physiology  (IAGP)
abnormal thymocyte activation  (IAGP)
brain inflammation  (IAGP)
decreased B cell number  (IAGP)
decreased CD4-positive, alpha-beta T cell number  (IAGP)
decreased circulating interferon-gamma level  (IAGP)
decreased circulating interleukin-4 level  (IAGP)
decreased cytotoxic T cell cytolysis  (IAGP)
decreased IgG1 level  (IAGP)
decreased IgG2a level  (IAGP)
decreased IgG2b level  (IAGP)
decreased IgM level  (IAGP)
decreased immunoglobulin level  (IAGP)
decreased interferon-gamma secretion  (IAGP)
decreased interleukin-12 secretion  (IAGP)
decreased interleukin-2 secretion  (IAGP)
decreased interleukin-4 secretion  (IAGP)
decreased locomotor activity  (IAGP)
decreased lymphoma incidence  (IAGP)
decreased regulatory T cell number  (IAGP)
decreased spleen germinal center number  (IAGP)
decreased splenocyte proliferation  (IAGP)
decreased susceptibility to experimental autoimmune encephalomyelitis  (IAGP)
decreased susceptibility to type IV hypersensitivity reaction  (IAGP)
decreased T cell number  (IEA)
decreased T cell proliferation  (IAGP)
enlarged lymph nodes  (IAGP)
enlarged spleen  (IAGP)
enlarged thymus  (IAGP)
esophageal inflammation  (IAGP)
focal hair loss  (IAGP)
hunched posture  (IAGP)
increased activated T cell number  (IAGP)
increased B cell number  (IAGP)
increased CD4-positive, alpha-beta T cell number  (IAGP)
increased CD8-positive, alpha-beta T cell number  (IAGP)
increased eosinophil cell number  (IAGP)
increased IgG2a level  (IAGP)
increased interferon-gamma secretion  (IAGP)
increased interleukin-2 secretion  (IAGP)
increased interleukin-4 secretion  (IAGP)
increased length of allograft survival  (IAGP)
increased leukocyte cell number  (IEA)
increased memory T cell number  (IAGP)
increased splenocyte proliferation  (IAGP)
increased susceptibility to autoimmune diabetes  (IAGP)
increased susceptibility to autoimmune disorder  (IAGP)
increased susceptibility to experimental autoimmune encephalomyelitis  (IAGP)
increased susceptibility to parasitic infection  (IAGP)
increased susceptibility to type I hypersensitivity reaction  (IAGP)
increased T cell apoptosis  (IAGP)
increased T cell derived lymphoma incidence  (IAGP)
increased T cell proliferation  (IAGP)
insulitis  (IAGP)
no abnormal phenotype detected  (IAGP)
ruffled hair  (IAGP)
skin inflammation  (IAGP)
skin lesions  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Neonatal activation of CD28 signaling overcomes T cell anergy and prevents autoimmune diabetes by an IL-4-dependent mechanism. Arreaza GA, etal., J Clin Invest. 1997 Nov 1;100(9):2243-53.
2. Induction of autoimmunity in the absence of CD28 costimulation. Bachmaier K, etal., J Immunol. 1996 Aug 15;157(4):1752-7.
3. A role for dendritic cells in bleomycin-induced pulmonary fibrosis in mice? Bantsimba-Malanda C, etal., Am J Respir Crit Care Med. 2010 Aug 1;182(3):385-95. Epub 2010 Apr 15.
4. Phenotypic characterisation of T-lymphocytes in COPD: abnormal CD4+CD25+ regulatory T-lymphocyte response to tobacco smoking. Barcelo B, etal., Eur Respir J. 2008 Mar;31(3):555-62. Epub 2007 Dec 5.
5. Selective targeting of regulatory T cells with CD28 superagonists allows effective therapy of experimental autoimmune encephalomyelitis. Beyersdorf N, etal., J Exp Med. 2005 Aug 1;202(3):445-55.
6. Differences in allergen-induced T cell activation between allergic asthma and rhinitis: Role of CD28, ICOS and CTLA-4. Botturi K, etal., Respir Res. 2011 Feb 28;12:25.
7. A critical role for DAP10 and DAP12 in CD8+ T cell-mediated tissue damage in large granular lymphocyte leukemia. Chen X, etal., Blood. 2009 Apr 2;113(14):3226-34. Epub 2008 Dec 15.
8. Dendritic Cells and CD28 Costimulation Are Required To Sustain Virus-Specific CD8+ T Cell Responses during the Effector Phase In Vivo. Dolfi DV, etal., J Immunol. 2011 Apr 15;186(8):4599-608. Epub 2011 Mar 9.
9. Rapid recovery from T lymphopenia by CD28 superagonist therapy. Elflein K, etal., Blood. 2003 Sep 1;102(5):1764-70. Epub 2003 May 15.
10. CD28 exerts protective and detrimental effects in a pulmonary model of paracoccidioidomycosis. Felonato M, etal., Infect Immun. 2010 Nov;78(11):4922-35. Epub 2010 Aug 16.
11. CD8+ T cell responses in bronchoalveolar lavage fluid and peripheral blood mononuclear cells of infants with severe primary respiratory syncytial virus infections. Heidema J, etal., J Immunol. 2007 Dec 15;179(12):8410-7.
12. T-cell activation profiles in different granulomatous interstitial lung diseases--a role for CD8+CD28(null) cells? Heron M, etal., Clin Exp Immunol. 2010 May;160(2):256-65. Epub 2009 Dec 17.
13. Association studies of CTLA-4, CD28, and ICOS gene polymorphisms with type 1 diabetes in the Japanese population. Ihara K, etal., Immunogenetics. 2001 Aug;53(6):447-54.
14. T cell senescence and contraction of T cell repertoire diversity in patients with chronic obstructive pulmonary disease. Lambers C, etal., Clin Exp Immunol. 2009 Mar;155(3):466-75.
15. [Effects of Tongbi Mixture 2 on expressions of CD28 and CD152 and content of tumor necrosis factor-alpha in peripheral blood in rats with collagen-induced arthritis] Liu H, etal., Zhong Xi Yi Jie He Xue Bao. 2008 Jul;6(7):744-7.
16. Immunological aspects of chronic fatigue syndrome. Lorusso L, etal., Autoimmun Rev. 2009 Feb;8(4):287-91. Epub 2008 Sep 16.
17. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
18. MGDs mouse GO annotations MGD data from the GO Consortium
19. MGD IEA MGD IEA
20. CD40 and CD80/86 act synergistically to regulate inflammation and mortality in polymicrobial sepsis. Nolan A, etal., Am J Respir Crit Care Med. 2008 Feb 1;177(3):301-8. Epub 2007 Nov 7.
21. [Surface expression of costimulatory molecules CD28/CTLA-4 on peripheral blood T lymphocytes in the course of type 1 diabetes mellitus in children and adolescents] Pawlowski P, etal., Endokrynol Diabetol Chor Przemiany Materii Wieku Rozw. 2004;10(2):81-5.
22. Low dose streptozotocin-induced diabetes in rat insulin promoter-mCD80-transgenic mice is T cell autoantigen-specific and CD28 dependent. Pechhold K, etal., J Immunol. 2001 Feb 15;166(4):2531-9.
23. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
24. Mouse MP Annotation Import Pipeline RGD automated import pipeline
25. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
26. Treatment and prevention of experimental autoimmune neuritis with superagonistic CD28-specific monoclonal antibodies. Schmidt J, etal., J Neuroimmunol. 2003 Jul;140(1-2):143-52.
27. Association of common T cell activation gene polymorphisms with multiple sclerosis in Australian patients. Teutsch SM, etal., J Neuroimmunol 2004 Mar;148(1-2):218-30.
28. Treatment and prevention of experimental autoimmune myocarditis with CD28 superagonists. Wang S, etal., Cardiology. 2010;115(2):107-13. doi: 10.1159/000256660. Epub 2009 Nov 10.
Additional References at PubMed
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PMID:11698438   PMID:11698463   PMID:11707574   PMID:11723074   PMID:11801669   PMID:11826754   PMID:11837936   PMID:11861872   PMID:11884443   PMID:11908941   PMID:11929778   PMID:11937529  
PMID:11937538   PMID:11937552   PMID:11958588   PMID:11970987   PMID:12044964   PMID:12047751   PMID:12055251   PMID:12070288   PMID:12077322   PMID:12096029   PMID:12097399   PMID:12142553  
PMID:12147624   PMID:12193687   PMID:12193694   PMID:12218136   PMID:12239309   PMID:12391201   PMID:12432568   PMID:12444136   PMID:12466851   PMID:12471093   PMID:12477932   PMID:12496383  
PMID:12515810   PMID:12525576   PMID:12538664   PMID:12538715   PMID:12574364   PMID:12574376   PMID:12591901   PMID:12594842   PMID:12626553   PMID:12663542   PMID:12672399   PMID:12707299  
PMID:12752681   PMID:12759417   PMID:12829795   PMID:12835481   PMID:12867038   PMID:12874832   PMID:12902500   PMID:12923072   PMID:12925852   PMID:12937416   PMID:12946999   PMID:12960172  
PMID:12960297   PMID:14499118   PMID:14500627   PMID:14500690   PMID:14501867   PMID:14523041   PMID:14581610   PMID:14586728   PMID:14625545   PMID:14634147   PMID:14701943   PMID:14707048  
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PMID:15135297   PMID:15187121   PMID:15210771   PMID:15210777   PMID:15210826   PMID:15213110   PMID:15240667   PMID:15294937   PMID:15314039   PMID:15356139   PMID:15357951   PMID:15385476  
PMID:15467837   PMID:15488732   PMID:15494542   PMID:15514586   PMID:15536066   PMID:15539158   PMID:15585831   PMID:15585834   PMID:15611240   PMID:15629449   PMID:15634900   PMID:15634938  
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PMID:25533288   PMID:25548162   PMID:25637021   PMID:25646266   PMID:25680271   PMID:25725801   PMID:25801976   PMID:25825447   PMID:25833397   PMID:26002824   PMID:26146074   PMID:26249010  
PMID:26301814   PMID:26408668   PMID:26485613   PMID:26507712   PMID:26711629   PMID:26773151   PMID:27122236   PMID:27180986   PMID:27183621   PMID:27396441   PMID:27432861   PMID:27460989  
PMID:27521344   PMID:27647348   PMID:28053234   PMID:28248972   PMID:28550204   PMID:28783663   PMID:28798231   PMID:28919076   PMID:29042364   PMID:29058713   PMID:29093061   PMID:29425339  
PMID:29661826   PMID:29712852   PMID:29773802   PMID:29862277   PMID:29909367   PMID:30007439   PMID:30148845   PMID:30320878   PMID:30607385   PMID:31010850   PMID:31565151   PMID:31636135  
PMID:31885821   PMID:32406182   PMID:32414925   PMID:32457739   PMID:32579940   PMID:32765524   PMID:33158954   PMID:33168576   PMID:33169838   PMID:33293517   PMID:33561807   PMID:33638630  
PMID:33895168   PMID:34145060   PMID:34157302   PMID:34214472   PMID:34236047   PMID:34281386   PMID:34788602   PMID:35316657   PMID:35417685   PMID:35651611   PMID:36388982   PMID:36397436  
PMID:36450247   PMID:36935092   PMID:37090733   PMID:37160118   PMID:37593744   PMID:38355793   PMID:38830487   PMID:38861924  


Genomics

Comparative Map Data
Cd28
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39160,785,547 - 60,812,521 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl160,755,959 - 60,812,518 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38160,746,388 - 60,773,359 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl160,716,800 - 60,773,359 (+)Ensemblmm10GRCm38
MGSCv37160,803,232 - 60,830,203 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36160,691,012 - 60,717,905 (+)NCBIMGSCv36mm8
Celera161,261,669 - 61,288,639 (+)NCBICelera
Cytogenetic Map1C2NCBI
cM Map130.52NCBI
CD28
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382203,706,482 - 203,738,912 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2203,706,517 - 203,739,756 (+)Ensemblhg38GRCh38
GRCh372204,571,205 - 204,603,635 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362204,279,443 - 204,310,801 (+)NCBIBuild 36Build 36hg18NCBI36
Build 342204,396,703 - 204,428,062NCBI
Celera2198,326,049 - 198,357,410 (+)NCBICelera
Cytogenetic Map2q33.2NCBI
HuRef2196,418,462 - 196,450,899 (+)NCBIHuRef
CHM1_12204,577,787 - 204,610,219 (+)NCBICHM1_1
T2T-CHM13v2.02204,188,401 - 204,220,837 (+)NCBIT2T-CHM13v2.0
Cd28
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8969,660,316 - 69,689,192 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl969,545,326 - 69,689,192 (+)EnsemblGRCr8
mRatBN7.2962,166,324 - 62,194,674 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl962,166,192 - 62,194,685 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx970,668,268 - 70,693,746 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0975,783,858 - 75,809,336 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0974,102,440 - 74,127,918 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0967,546,408 - 67,573,858 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl967,546,408 - 67,571,871 (+)Ensemblrn6Rnor6.0
Rnor_5.0967,358,994 - 67,386,424 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4959,342,273 - 59,367,743 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera959,589,124 - 59,614,592 (+)NCBICelera
RGSC_v3.1959,489,254 - 59,514,725 (+)NCBI
RH 3.4 Map9504.6RGD
Cytogenetic Map9q32NCBI
Cd28
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545711,162,282 - 11,192,991 (-)Ensembl
ChiLan1.0NW_00495545711,159,769 - 11,253,099 (-)NCBIChiLan1.0ChiLan1.0
CD28
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213106,310,207 - 106,343,899 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B106,325,199 - 106,358,891 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B90,938,795 - 90,971,438 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B209,076,388 - 209,111,213 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B209,076,388 - 209,111,213 (+)EnsemblpanPan2panpan1.1
CD28
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13712,503,849 - 12,536,362 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3712,503,811 - 12,532,854 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3713,387,259 - 13,416,196 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03712,440,597 - 12,473,128 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3712,440,613 - 12,471,203 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13712,397,782 - 12,426,685 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03712,360,914 - 12,389,827 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03712,361,906 - 12,391,080 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Cd28
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303160,682,644 - 160,728,827 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936631335,411 - 363,407 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936631335,411 - 363,407 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CD28
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15107,128,203 - 107,162,935 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.115107,128,103 - 107,155,431 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215118,472,553 - 118,502,433 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CD28
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11089,471,710 - 89,505,152 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1089,471,730 - 89,500,387 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666040109,879,825 - 109,913,281 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cd28
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476512,650,092 - 12,667,168 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Cd28
1281 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:1236
Count of miRNA genes:606
Interacting mature miRNAs:765
Transcripts:ENSMUST00000027165, ENSMUST00000132833, ENSMUST00000153207
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11039528Ccc3_mcolitis susceptibility in the Collaborative Cross 3 (mouse)13680142195051546Mouse
12910788Pwgrq9_mpost-weaning growth rate QTL 9 (mouse)14086800867270256Mouse
18182931Metl1_mmetabolite locus 1, pyridoxate (mouse)14127539975275399Mouse
12910786Pwgrq10_mpost-weaning growth rate QTL 10 (mouse)14086800867270256Mouse
13824984Twq5_mtestis weight QTL 5 (mouse)13069992184732197Mouse
1357721Sle17_msystematic lupus erythematosus susceptibility 17 (mouse)Not determined139132808126445310Mouse
1357824Estoq4_membryo survival total QTL 4 (mouse)Not determined13476013873976915Mouse
14746998Mancz1_mmandible centroid size 1 (mouse)15794135191941351Mouse
1300746Skl1_mskeletal size (tail length) 1 (mouse)Not determined15799197791992080Mouse
4141724Idd5.1_minsulin dependent diabetes susceptibility 5.1 (mouse)Not determined5772827662946882Mouse
1357488Splq3_mspleen weight QTL 3 (mouse)Not determined134760138150193871Mouse
10043965Obq24_mobesity QTL 24 (mouse)Not determined15089021684890216Mouse
1301430Cdcs2_mcytokine deficiency colitis susceptibility 2 (mouse)Not determined14889234582892485Mouse
1558717Ses1a_msalmonella enteritidis susceptibility 1a (mouse)Not determined15672692290727077Mouse
1357759W3q12_mweight 3 weeks QTL 12 (mouse)Not determined13476013873976915Mouse
1357753Kidq2_mkidney weight QTL 2 (mouse)Not determined134760138150193871Mouse
1301667Lxw5_mlupus BXSB x NZW 5 (mouse)Not determined15854919192549443Mouse
1558822Vas1_mautoimmune vasitis resistance 1 (mouse)Not determined14888900682889210Mouse
1301670Ssta1_msusceptibility to Salmonella typhimurium antigens 1 (mouse)Not determined14594675579946882Mouse
1357475w3q13_mweight 3 weeks QTL 13 (mouse)Not determined12310959173976915Mouse
1357741Nidd5k_mNidd5 on KK-A<y> (mouse)Not determined15597494889975057Mouse
1301162Skull1_mskull morphology 1 (mouse)Not determined15799197791992080Mouse
4142467Wbcq1_mwhite blood cell quantitative locus 1 (mouse)Not determined15626621490266360Mouse
1301166Thypr2_mthymocyte proliferative response 2 (mouse)Not determined14127312475273271Mouse
1301933Insq6_minsulin QTL 6 (mouse)Not determined15672692290727077Mouse
1357524W6q14_mweight 6 weeks QTL 14 (mouse)Not determined13476013873976915Mouse
1301714Vertcling_mvertical clinging (mouse)Not determined14293803176938167Mouse
4141305Tgq9_mtriglyceride QTL 9 (mouse)Not determined5142160585421605Mouse
1357651Lgq5_mlate growth QTL 5 (mouse)Not determined13476013873976915Mouse
11100001Col4a1m1_mcollagen, type IV, alpha 1 modifier 1 (mouse)12555019162946882Mouse
1301211Bbaa11_mB.burgdorferi-associated arthritis 11 (mouse)Not determined14888900682889210Mouse
1301722Cia9_mcollagen induced arthritis QTL 9 (mouse)Not determined145783900189303617Mouse
1558855Eae30_mexperimental allergic encephalomyelitis susceptibility 30 (mouse)Not determined14541777372975057Mouse
1301954Lrnx11_mlearning-contextual 11 (mouse)Not determined13913280874516365Mouse
1357505Vtbt1_mvertebral trabecular bone trait 1 (mouse)Not determined15626621490266360Mouse
1357506W10q6_mweight 10 weeks QTL 6 (mouse)Not determined13476013873976915Mouse
4141032Wbcc1_mwhite blood cell count 1 (mouse)Not determined4225966776259667Mouse
1301444Alcw5_malcohol withdrawal 5 (mouse)Not determined15854919192549443Mouse
39128207Lwq16_mliver weight QTL 16 (mouse)13476013873976915Mouse
1558860W10q7_mweight 10 weeks QTL 7 (mouse)Not determined134760138150193871Mouse
4142307Shali1_msurvival time to hyperoxic acute lung injury 1 (mouse)Not determined5196402570406589Mouse
14747009Manh49_mmandible shape 49 (mouse)15794135191941351Mouse
1301616Yaa2_mY-linked autoimmune acceleration 2 (mouse)Not determined14685469080854839Mouse
12879917Shm3_msperm head morphology 3 (mouse)14418690462946882Mouse
4142291Aec2_mautoimmune exocrinopathy 2 (mouse)Not determined52457737182250592Mouse
1558905Gct7_mgranulosa cell tumorigenesis 7 (mouse)Not determined14734989481350013Mouse
12910780Pwgrq11_mpost-weaning growth rate QTL 11 (mouse)14086800867270256Mouse
1301225Sle7_msystematic lupus erythematosus susceptibility 7 (mouse)Not determined14685469080854839Mouse
1357679Egrm1_mearly growth rate, maternal effect 1 (mouse)Not determined15799197791992080Mouse

Markers in Region
M34563  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38160,770,133 - 60,770,242UniSTSGRCm38
MGSCv37160,826,977 - 60,827,086UniSTSGRCm37
Celera161,285,413 - 61,285,522UniSTS
Cytogenetic Map1C1-C3UniSTS
Whitehead/MRC_RH1881.78UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000027165   ⟹   ENSMUSP00000027165
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl160,785,517 - 60,812,518 (+)Ensembl
GRCm38.p6 Ensembl160,746,358 - 60,773,359 (+)Ensembl
Ensembl Acc Id: ENSMUST00000132833
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl160,755,959 - 60,802,322 (+)Ensembl
GRCm38.p6 Ensembl160,716,800 - 60,763,163 (+)Ensembl
Ensembl Acc Id: ENSMUST00000153207
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl160,785,561 - 60,803,785 (+)Ensembl
GRCm38.p6 Ensembl160,746,402 - 60,764,626 (+)Ensembl
RefSeq Acc Id: NM_007642   ⟹   NP_031668
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39160,785,547 - 60,812,518 (+)NCBI
GRCm38160,746,388 - 60,773,359 (+)ENTREZGENE
MGSCv37160,803,232 - 60,830,203 (+)RGD
Celera161,261,669 - 61,288,639 (+)RGD
cM Map1 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_036156388   ⟹   XP_036012281
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39160,789,155 - 60,812,521 (+)NCBI
Sequence:
RefSeq Acc Id: NP_031668   ⟸   NM_007642
- Peptide Label: precursor
- UniProtKB: Q6GSH7 (UniProtKB/Swiss-Prot),   P31041 (UniProtKB/Swiss-Prot),   Q8CDB3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000027165   ⟸   ENSMUST00000027165
RefSeq Acc Id: XP_036012281   ⟸   XM_036156388
- Peptide Label: isoform X1
- UniProtKB: Q8CDB3 (UniProtKB/TrEMBL)
Protein Domains
Ig-like V-type   Immunoglobulin V-set

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P31041-F1-model_v2 AlphaFold P31041 1-218 view protein structure

Promoters
RGD ID:6873898
Promoter ID:EPDNEW_M393
Type:initiation region
Name:Cd28_1
Description:Mus musculus CD28 antigen , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38160,746,410 - 60,746,470EPDNEW
RGD ID:6817485
Promoter ID:MM_KWN:914
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lung,   Spleen
Transcripts:OTTMUST00000004499,   OTTMUST00000004500
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36160,803,049 - 60,803,549 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:88327 AgrOrtholog
Ensembl Genes ENSMUSG00000026012 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000027165 ENTREZGENE
  ENSMUST00000027165.3 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot
InterPro CD28 UniProtKB/Swiss-Prot
  CTLA4/CD28 UniProtKB/Swiss-Prot
  Ig-like_dom_sf UniProtKB/Swiss-Prot
  Ig-like_fold UniProtKB/Swiss-Prot
  Ig_V-set UniProtKB/Swiss-Prot
KEGG Report mmu:12487 UniProtKB/Swiss-Prot
MGD MGI:88327 ENTREZGENE
NCBI Gene 12487 ENTREZGENE
PANTHER PTHR11494 UniProtKB/Swiss-Prot
  T-CELL-SPECIFIC SURFACE GLYCOPROTEIN CD28 UniProtKB/Swiss-Prot
Pfam V-set UniProtKB/Swiss-Prot
PhenoGen Cd28 PhenoGen
PRINTS CD28ANTIGEN UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot
UniProt CD28_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q6GSH7 ENTREZGENE
  Q8CDB3 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q6GSH7 UniProtKB/Swiss-Prot