Bmp4 (bone morphogenetic protein 4) - Rat Genome Database

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Gene: Bmp4 (bone morphogenetic protein 4) Mus musculus
Analyze
Symbol: Bmp4
Name: bone morphogenetic protein 4
RGD ID: 10244
MGI Page MGI
Description: Enables heparin binding activity. Involved in several processes, including circulatory system development; kidney development; and ureter development. Acts upstream of or within several processes, including embryonic morphogenesis; morphogenesis of a branching epithelium; and nervous system development. Located in extracellular space. Is expressed in several structures, including alimentary system; embryo ectoderm; embryo mesenchyme; genitourinary system; and sensory organ. Used to study Axenfeld-Rieger syndrome type 3; atrioventricular septal defect; cleft palate-lateral synechia syndrome; fibrodysplasia ossificans progressiva; and urinary system disease. Human ortholog(s) of this gene implicated in several diseases, including CAKUT (multiple); cleft lip; orofacial cleft 11; ossification of the posterior longitudinal ligament of spine; and otosclerosis. Orthologous to human BMP4 (bone morphogenetic protein 4).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: Bmp-; BMP-2B; Bmp-4; Bmp2; Bmp2b; Bmp2b-; Bmp2b-1; Bmp2b1; bone morphogenetic protein 2B
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Bmp4-ps  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391446,620,982 - 46,628,126 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1446,620,977 - 46,628,126 (-)EnsemblGRCm39 Ensembl
GRCm381446,383,525 - 46,390,669 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1446,383,520 - 46,390,669 (-)EnsemblGRCm38mm10GRCm38
MGSCv371447,003,195 - 47,010,274 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361445,305,736 - 45,309,065 (-)NCBIMGSCv36mm8
Celera1442,555,453 - 42,562,519 (-)NCBICelera
Cytogenetic Map14C1NCBI
cM Map1423.95NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
ACTH-secreting pituitary adenoma  (ISO)
Acute Otitis Media  (IEP)
Alzheimer's disease  (IEP)
amenorrhea  (ISO)
Anorectal Malformations  (ISO)
APLASIA/HYPOPLASIA INVOLVING BONES OF THE LOWER LIMBS  (ISO)
atrial heart septal defect  (ISO)
atrioventricular septal defect  (IAGP)
Axenfeld-Rieger syndrome type 3  (IAGP)
Barrett's esophagus  (ISO)
Brain Hypoxia-Ischemia  (ISO)
breast cancer  (ISO)
Breast Neoplasms  (ISO)
CAKUT  (ISO)
CAKUT2  (ISO)
calcinosis  (ISO)
Cardiomegaly  (IEP)
cartilage disease  (ISO)
Cartilage Fractures  (ISO)
CHARGE syndrome  (IEP)
Choroidal Neovascularization  (IDA,IEP)
cleft lip  (ISO)
cleft palate-lateral synechia syndrome  (IAGP)
Colorectal Neoplasms  (ISO)
congenital diaphragmatic hernia  (ISO)
Congenital Limb Deformities  (ISO)
Cranial Nerve Injuries  (ISO)
Diaphragmatic Hernia  (ISO)
dystonia 5  (ISO)
Endometrioid Carcinomas  (ISO)
epilepsy  (ISO)
esophagitis  (ISO)
Experimental Liver Cirrhosis  (ISO)
Femoral Fractures  (ISO)
Fetal Growth Retardation  (ISO)
fibrodysplasia ossificans progressiva  (IAGP)
Focal Cortical Dysplasia of Taylor  (ISO)
genetic disease  (ISO)
Gliosis  (ISO)
granulosa cell tumor  (IEP)
Hearing Loss  (IMP)
hereditary spastic paraplegia 28  (ISO)
Hyperoxia  (ISO)
isolated microphthalmia 3  (ISO)
keratoconus  (ISO)
macular degeneration  (ISO)
melanoma  (ISO)
Multicystic Dysplastic Kidney  (ISO)
myositis ossificans  (ISO)
ocular hypertension  (IMP)
Oral Lichen Planus  (ISO)
orofacial cleft  (ISO)
orofacial cleft 11  (ISO)
ossification of the posterior longitudinal ligament of spine  (ISO)
osteoarthritis  (ISO)
Osteoarthritis, Experimental  (ISO)
osteoporosis  (ISO)
otosclerosis  (ISO)
peptic esophagitis  (ISO)
Peters anomaly  (ISO)
physical disorder  (IAGP)
progressive osseous heteroplasia  (ISO)
prolactinoma  (IEP,ISO)
prostate carcinoma  (ISO)
psoriatic arthritis  (ISO)
renal cell carcinoma  (ISO)
rheumatoid arthritis  (ISO)
Skull Fractures  (ISO)
Spinal Cord Injuries  (ISO)
strabismus  (ISO)
Stroke  (ISO)
syndromic microphthalmia  (ISO)
syndromic microphthalmia 6  (ISO)
Tibial Fractures  (ISO)
tooth agenesis  (ISO)
Tracheoesophageal Fistula  (ISO)
tuberous sclerosis  (ISO)
urinary system disease  (IAGP)
Vitamin A Deficiency  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(S)-amphetamine  (EXP)
(S)-nicotine  (ISO)
1,1-bis(2-aminoethyl)-2-hydroxy-3-oxotriazane  (ISO)
1,2-dimethylhydrazine  (EXP)
1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
3-methylcholanthrene  (ISO)
3-Nitrobenzanthrone  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (EXP)
5-aza-2'-deoxycytidine  (EXP)
8-Br-cAMP  (ISO)
acrylamide  (EXP)
aldehydo-D-glucosamine  (ISO)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (EXP)
aluminium oxide  (ISO)
ammonium chloride  (ISO)
angiotensin II  (EXP)
antimonite  (ISO)
aristolochic acid A  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (ISO)
atrazine  (EXP)
bacitracin  (ISO)
benzo[a]pyrene  (EXP,ISO)
beta-D-glucosamine  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bucladesine  (ISO)
busulfan  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (EXP)
casticin  (ISO)
CGP 52608  (ISO)
CHIR 99021  (ISO)
choline  (EXP)
chromium(6+)  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cyclosporin A  (ISO)
cytarabine  (ISO)
dexamethasone  (EXP,ISO)
dibutyl phthalate  (ISO)
dichlorine  (ISO)
dichromium trioxide  (ISO)
diclofenac  (ISO)
Didecyldimethylammonium  (EXP)
dioxygen  (EXP)
disodium selenite  (EXP,ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
endosulfan  (ISO)
ethylenediaminetetraacetic acid  (ISO)
Ethylenethiourea  (ISO)
flavonoids  (ISO)
flusilazole  (EXP)
folic acid  (EXP)
fulvestrant  (ISO)
furan  (ISO)
genistein  (EXP)
gentamycin  (ISO)
glycidol  (ISO)
hydrogen peroxide  (EXP,ISO)
icariin  (EXP,ISO)
iloprost  (ISO)
indole-3-methanol  (ISO)
isoprenaline  (ISO)
kaempferol  (EXP)
L-ascorbic acid  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
L-methionine  (EXP)
lead diacetate  (EXP,ISO)
linuron  (ISO)
lipopolysaccharide  (ISO)
lithium chloride  (ISO)
maneb  (EXP)
manganese(II) chloride  (EXP)
mercury dibromide  (ISO)
methotrexate  (EXP,ISO)
methylmercury chloride  (ISO)
methylseleninic acid  (ISO)
mitomycin C  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
naringin  (ISO)
nickel sulfate  (ISO)
nicotine  (ISO)
nitrates  (ISO)
nitrofen  (ISO)
ochratoxin A  (ISO)
octreotide  (ISO)
orphenadrine  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
paclitaxel  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
paricalcitol  (ISO)
pasireotide  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
phenylephrine  (ISO)
phenylmercury acetate  (ISO)
phenytoin  (EXP)
phosphorus atom  (ISO)
phosphorus(.)  (ISO)
pinosylvin  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
Ptaquiloside  (EXP)
quercetin  (ISO)
resveratrol  (EXP,ISO)
retinyl acetate  (EXP)
rifampicin  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (EXP,ISO)
silver(0)  (EXP,ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium chlorate  (ISO)
sodium dichromate  (ISO)
sulforaphane  (EXP)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
thioacetamide  (ISO)
topotecan  (ISO)
trans-pinosylvin  (ISO)
trichostatin A  (ISO)
tyrphostin AG 1478  (ISO)
urethane  (EXP,ISO)
valproic acid  (EXP,ISO)
valsartan  (ISO)
vinclozolin  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)
XAV939  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
ameloblast differentiation  (IDA)
anatomical structure development  (IGI)
anatomical structure formation involved in morphogenesis  (IGI)
anatomical structure regression  (ISO)
angiogenesis  (IMP)
anterior/posterior axis specification  (IGI)
aortic valve morphogenesis  (IMP)
apoptotic process involved in endocardial cushion morphogenesis  (IMP)
blood vessel development  (IDA)
blood vessel endothelial cell proliferation involved in sprouting angiogenesis  (ISO)
BMP signaling pathway  (IBA,IDA,IGI,ISO)
BMP signaling pathway involved in heart development  (IMP)
BMP signaling pathway involved in heart induction  (ISO)
BMP signaling pathway involved in nephric duct formation  (ISO)
BMP signaling pathway involved in renal system segmentation  (IMP)
BMP signaling pathway involved in ureter morphogenesis  (IDA)
bone development  (IDA)
branching involved in prostate gland morphogenesis  (IMP)
branching involved in ureteric bud morphogenesis  (IGI,ISO)
branching morphogenesis of an epithelial tube  (ISO)
bronchus development  (ISO)
bud dilation involved in lung branching  (ISO)
bud elongation involved in lung branching  (IDA)
camera-type eye development  (IGI,IMP)
camera-type eye morphogenesis  (IMP)
cardiac jelly development  (IMP)
cardiac muscle cell differentiation  (IGI,NAS)
cardiac muscle hypertrophy in response to stress  (ISO)
cardiac right ventricle morphogenesis  (IMP)
cartilage development  (IEA)
cell differentiation  (IEA)
cell fate commitment  (IDA)
cell population proliferation  (IGI)
cellular response to BMP stimulus  (ISO)
cellular response to dexamethasone stimulus  (ISO)
cellular response to growth factor stimulus  (IDA)
cellular response to mechanical stimulus  (ISO)
cellular response to oxidative stress  (ISO)
cellular response to thyroid hormone stimulus  (ISO)
chondrocyte differentiation  (IDA,IMP)
cloacal septation  (IEP)
common-partner SMAD protein phosphorylation  (ISO)
coronary vasculature development  (IMP)
cranial suture morphogenesis  (IDA)
deltoid tuberosity development  (IMP)
dorsal/ventral neural tube patterning  (IDA)
embryonic cranial skeleton morphogenesis  (IMP)
embryonic digit morphogenesis  (IGI)
embryonic hindlimb morphogenesis  (IGI)
embryonic limb morphogenesis  (IGI,IMP)
embryonic morphogenesis  (IMP)
embryonic skeletal joint morphogenesis  (IGI,IMP)
embryonic skeletal system development  (IMP)
embryonic skeletal system morphogenesis  (IMP)
endocardial cushion development  (IMP)
endochondral ossification  (IMP)
endoderm development  (IDA)
epithelial cell proliferation  (IGI)
epithelial cell proliferation involved in lung morphogenesis  (ISO)
epithelial to mesenchymal transition involved in endocardial cushion formation  (IMP)
epithelial tube branching involved in lung morphogenesis  (ISO)
epithelial-mesenchymal cell signaling  (IDA)
epithelium development  (IDA)
erythrocyte differentiation  (IDA)
eye development  (IGI)
forebrain development  (IGI,IMP)
gene expression  (IDA)
germ cell development  (IMP)
glomerular capillary formation  (IMP)
heart development  (IMP)
hematopoietic progenitor cell differentiation  (IDA,ISO)
inner ear auditory receptor cell differentiation  (IGI)
intermediate mesodermal cell differentiation  (ISO)
kidney development  (IGI,IMP,ISO)
lens induction in camera-type eye  (IMP)
lung alveolus development  (ISO)
lung development  (IMP)
lung lobe development  (ISO)
lung morphogenesis  (ISO)
lymphoid progenitor cell differentiation  (ISO)
macrophage differentiation  (ISO)
mammary gland formation  (IMP)
membranous septum morphogenesis  (IMP)
mesenchymal cell differentiation involved in kidney development  (IMP)
mesenchymal cell differentiation involved in renal system development  (IMP)
mesenchymal cell proliferation involved in ureter development  (IEP)
mesenchymal cell proliferation involved in ureteric bud development  (IEP)
mesenchymal to epithelial transition involved in metanephros morphogenesis  (ISO)
mesoderm formation  (IDA)
mesodermal cell differentiation  (IDA)
mesodermal cell fate determination  (IMP)
mesonephros development  (ISO)
metanephric collecting duct development  (IMP)
metanephros development  (IDA,IMP)
monocyte differentiation  (ISO)
muscular septum morphogenesis  (IMP)
negative regulation of apoptotic process  (IBA,ISO)
negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway  (ISO)
negative regulation of branching involved in ureteric bud morphogenesis  (IDA,IGI,ISO)
negative regulation of cell cycle  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of cell proliferation involved in heart morphogenesis  (ISO)
negative regulation of chondrocyte differentiation  (IDA)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of epithelial cell proliferation  (IGI,IMP)
negative regulation of extrinsic apoptotic signaling pathway  (IMP)
negative regulation of gene expression  (IDA,ISO)
negative regulation of glomerular mesangial cell proliferation  (ISO)
negative regulation of glomerulus development  (ISO)
negative regulation of immature T cell proliferation in thymus  (ISO)
negative regulation of MAP kinase activity  (ISO)
negative regulation of mesenchymal cell proliferation involved in ureter development  (ISO)
negative regulation of metanephric comma-shaped body morphogenesis  (ISO)
negative regulation of metanephric S-shaped body morphogenesis  (ISO)
negative regulation of miRNA transcription  (ISO)
negative regulation of mitotic nuclear division  (ISO)
negative regulation of myoblast differentiation  (ISO)
negative regulation of oligodendrocyte differentiation  (ISO)
negative regulation of phosphorylation  (ISO)
negative regulation of prostatic bud formation  (IDA,IMP)
negative regulation of striated muscle tissue development  (ISO)
negative regulation of T cell differentiation in thymus  (ISO)
negative regulation of thymocyte apoptotic process  (ISO)
negative regulation of transcription by RNA polymerase II  (IBA,IDA,IMP,ISO)
neural tube closure  (IDA)
neuron fate commitment  (IDA,IMP)
odontogenesis  (ISO)
odontogenesis of dentin-containing tooth  (IDA,IGI)
organ induction  (IMP)
ossification  (IEA)
osteoblast differentiation  (IDA,ISO)
outflow tract morphogenesis  (IGI)
outflow tract septum morphogenesis  (IMP)
ovarian follicle development  (ISO)
pericyte cell differentiation  (IDA)
pharyngeal arch artery morphogenesis  (IMP)
pituitary gland development  (IMP)
podocyte development  (IEP)
positive regulation of apoptotic process  (ISO)
positive regulation of BMP signaling pathway  (IDA)
positive regulation of bone mineralization  (ISO)
positive regulation of branching involved in lung morphogenesis  (IMP)
positive regulation of branching involved in ureteric bud morphogenesis  (ISO)
positive regulation of calcium ion transport into cytosol  (ISO)
positive regulation of cardiac muscle fiber development  (ISO)
positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis  (IGI)
positive regulation of cartilage development  (ISO)
positive regulation of cell migration  (IMP)
positive regulation of cell population proliferation  (IMP,ISO)
positive regulation of cell proliferation involved in outflow tract morphogenesis  (IMP)
positive regulation of collagen biosynthetic process  (ISO)
positive regulation of DNA-templated transcription  (ISO,TAS)
positive regulation of endothelial cell apoptotic process  (ISO)
positive regulation of endothelial cell differentiation  (IDA)
positive regulation of endothelial cell migration  (ISO,TAS)
positive regulation of endothelial cell proliferation  (IDA,ISO)
positive regulation of epidermal cell differentiation  (ISO)
positive regulation of epithelial cell differentiation  (IDA)
positive regulation of epithelial cell proliferation  (ISO)
positive regulation of epithelial to mesenchymal transition  (IGI)
positive regulation of ERK1 and ERK2 cascade  (IDA)
positive regulation of gene expression  (IDA,IMP,ISO)
positive regulation of hepatocyte differentiation  (ISO)
positive regulation of kidney development  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of mesenchymal stem cell proliferation  (ISO)
positive regulation of miRNA transcription  (IGI)
positive regulation of neuron differentiation  (IDA,ISO)
positive regulation of neuron projection development  (ISO)
positive regulation of ossification  (IDA,ISO)
positive regulation of osteoblast differentiation  (ISO)
positive regulation of p38MAPK cascade  (ISO)
positive regulation of pathway-restricted SMAD protein phosphorylation  (IBA,ISO)
positive regulation of primary miRNA processing  (ISO)
positive regulation of programmed cell death  (ISO)
positive regulation of protein binding  (ISO)
positive regulation of protein phosphorylation  (IMP,ISO)
positive regulation of SMAD protein signal transduction  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of store-operated calcium channel activity  (ISO)
positive regulation of transcription by RNA polymerase II  (IDA,IGI,IMP,ISO)
positive regulation of vascular endothelial growth factor receptor signaling pathway  (TAS)
post-embryonic development  (IMP,ISO)
programmed cell death  (ISO)
prostate gland morphogenesis  (IMP)
prostatic bud formation  (IMP)
protein localization to nucleus  (ISO)
pulmonary artery endothelial tube morphogenesis  (ISO)
pulmonary valve morphogenesis  (IMP)
regulation of branching involved in prostate gland morphogenesis  (IMP)
regulation of cartilage development  (IDA)
regulation of cell differentiation  (IGI,ISO)
regulation of cell fate commitment  (ISO)
regulation of endothelial cell proliferation  (TAS)
regulation of ERK1 and ERK2 cascade  (ISO)
regulation of gene expression  (IDA,IMP)
regulation of mesodermal cell differentiation  (IDA,IGI)
regulation of miRNA transcription  (ISO)
regulation of morphogenesis of a branching structure  (IMP)
regulation of odontogenesis of dentin-containing tooth  (IGI)
regulation of pathway-restricted SMAD protein phosphorylation  (ISO)
regulation of protein import into nucleus  (ISO)
regulation of smooth muscle cell differentiation  (IDA,IGI)
regulation of smooth muscle cell proliferation  (IDA)
renal system process  (IMP)
response to estradiol  (ISO)
response to glucocorticoid  (ISO)
response to mechanical stimulus  (ISO)
response to nitric oxide  (ISO)
response to organic cyclic compound  (ISO)
response to retinoic acid  (ISO)
response to testosterone  (ISO)
retina development in camera-type eye  (ISO)
secondary heart field specification  (ISO)
skeletal system development  (IDA,IMP)
SMAD protein signal transduction  (IBA,IDA,ISO)
smooth muscle cell differentiation  (IDA)
smooth muscle tissue development  (IMP)
specification of animal organ position  (IMP)
specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway  (ISO)
steroid hormone mediated signaling pathway  (ISO)
telencephalon development  (ISO)
telencephalon regionalization  (IDA,IGI)
tendon cell differentiation  (IMP)
tongue morphogenesis  (ISO)
trachea development  (ISO)
trachea formation  (IMP)
transcription by RNA polymerase II  (IDA)
type B pancreatic cell development  (ISO)
ureter epithelial cell differentiation  (IMP)
ureter smooth muscle cell differentiation  (IMP)
ureteric bud development  (IDA,IMP,ISO)
vasculature development  (IMP)

Cellular Component
extracellular region  (IDA,TAS)
extracellular space  (IBA,IDA,ISO)
vesicle  (ISO)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal allantois morphology  (IAGP)
abnormal amniotic cavity morphology  (IAGP)
abnormal angiogenesis  (IAGP)
abnormal anterior eye segment morphology  (IAGP)
abnormal aortic arch and aortic arch branch attachment  (IAGP)
abnormal apical ectodermal ridge morphology  (IAGP)
abnormal artery morphology  (IAGP)
abnormal atrioventricular cushion morphology  (IAGP)
abnormal autopod morphology  (IAGP)
abnormal bone marrow cavity morphology  (IAGP)
abnormal bone marrow development  (IAGP)
abnormal bone ossification  (IAGP)
abnormal canal of Schlemm morphology  (IAGP)
abnormal cardiac mesenchyme morphology  (IAGP)
abnormal cardiac outflow tract development  (IAGP)
abnormal cartilage development  (IAGP)
abnormal caudal vertebrae morphology  (IAGP)
abnormal chorion morphology  (IAGP)
abnormal conotruncal ridge morphology  (IAGP)
abnormal cornea morphology  (IAGP)
abnormal craniofacial bone morphology  (IAGP)
abnormal craniofacial morphology  (IAGP)
abnormal diencephalon morphology  (IAGP)
abnormal digit morphology  (IAGP)
abnormal ear development  (IAGP)
abnormal embryo development  (IEA)
abnormal embryo size  (IEA)
abnormal embryo turning  (IEA)
abnormal embryonic cloaca development  (IAGP)
abnormal endolymphatic duct morphology  (IAGP)
abnormal external female genitalia morphology  (IAGP)
abnormal extraembryonic mesoderm development  (IAGP)
abnormal eye anterior chamber depth  (IEA)
abnormal eye development  (IAGP)
abnormal eye distance/ position  (IAGP)
abnormal eye electrophysiology  (IAGP)
abnormal eye morphology  (IAGP)
abnormal eye size  (IAGP)
abnormal face development  (IAGP)
abnormal fertility/fecundity  (IAGP)
abnormal fibula morphology  (IAGP)
abnormal forebrain development  (IEA)
abnormal forebrain morphology  (IAGP)
abnormal foregut morphology  (IAGP)
abnormal forelimb morphology  (IAGP)
abnormal forelimb stylopod morphology  (IAGP)
abnormal forelimb zeugopod morphology  (IAGP)
abnormal frontal bone morphology  (IAGP)
abnormal head mesenchyme morphology  (IAGP)
abnormal heart and great artery attachment  (IAGP)
abnormal heart development  (IAGP)
abnormal heart looping  (IAGP)
abnormal heart morphology  (IEA)
abnormal heart right ventricle morphology  (IAGP)
abnormal heart right ventricle pressure  (IAGP)
abnormal heart ventricle outflow tract morphology  (IAGP)
abnormal hindbrain development  (IEA)
abnormal hindlimb bud morphology  (IAGP)
abnormal hindlimb stylopod morphology  (IAGP)
abnormal hindlimb zeugopod morphology  (IAGP)
abnormal inner ear morphology  (IAGP)
abnormal interdigital cell death  (IAGP)
abnormal interparietal bone morphology  (IAGP)
abnormal iridocorneal angle  (IAGP)
abnormal iris morphology  (IAGP)
abnormal kidney development  (IAGP)
abnormal kidney mesenchyme morphology  (IAGP)
abnormal lateral ganglionic eminence morphology  (IAGP)
abnormal lateral plate mesoderm morphology  (IAGP)
abnormal lateral semicircular canal morphology  (IAGP)
abnormal lens induction  (IAGP)
abnormal limb development  (IAGP)
abnormal line of Schwalbe morphology  (IAGP)
abnormal liver bud morphology  (IAGP)
abnormal long bone diaphysis morphology  (IAGP)
abnormal lung morphology  (IAGP)
abnormal male reproductive system morphology  (IAGP)
abnormal mandible morphology  (IAGP)
abnormal mandibular angle morphology  (IAGP)
abnormal mandibular condyloid process morphology  (IAGP)
abnormal maxilla morphology  (IAGP)
abnormal mesoderm development  (IAGP)
abnormal metanephric mesenchyme morphology  (IAGP)
abnormal midbrain development  (IEA)
abnormal mouth morphology  (IAGP)
abnormal nasal bone morphology  (IAGP)
abnormal nasal cartilage morphology  (IAGP)
abnormal nephrogenic zone morphology  (IAGP)
abnormal neural tube closure  (IEA)
abnormal nose morphology  (IAGP)
abnormal optic disk morphology  (IAGP)
abnormal optic nerve morphology  (IAGP)
abnormal organ of Corti morphology  (IAGP)
abnormal pharyngeal arch artery morphology  (IAGP)
abnormal placement of pupils  (IAGP)
abnormal posterior eye segment morphology  (IAGP)
abnormal posterior primitive streak morphology  (IAGP)
abnormal primitive node morphology  (IAGP)
abnormal prostate gland anterior lobe morphology  (IAGP)
abnormal pulmonary artery morphology  (IAGP)
abnormal renal glomerulus morphology  (IAGP)
abnormal renal/urinary system morphology  (IAGP)
abnormal respiratory system physiology  (IAGP)
abnormal retina blood vessel pattern  (IAGP)
abnormal retina inner nuclear layer morphology  (IEA)
abnormal retina morphology  (IAGP)
abnormal retina outer nuclear layer morphology  (IEA)
abnormal retina photoreceptor layer morphology  (IAGP)
abnormal rib morphology  (IAGP)
abnormal rostral-caudal axis patterning  (IAGP)
abnormal scala media morphology  (IAGP)
abnormal semicircular canal ampulla morphology  (IAGP)
abnormal semicircular canal morphology  (IAGP)
abnormal semilunar valve morphology  (IAGP)
abnormal seminiferous tubule morphology  (IAGP)
abnormal sensory neuron innervation pattern  (IAGP)
abnormal skeleton development  (IAGP)
abnormal snout morphology  (IAGP)
abnormal sternum morphology  (IAGP)
abnormal sternum ossification  (IAGP)
abnormal tail morphology  (IAGP)
abnormal temporal bone squamous part morphology  (IAGP)
abnormal thoracic cage morphology  (IAGP)
abnormal truncus arteriosus septation  (IAGP)
abnormal tympanic ring morphology  (IAGP)
abnormal ureter development  (IAGP)
abnormal ureter morphology  (IAGP)
abnormal ureter smooth muscle morphology  (IAGP)
abnormal ureteral orifice morphology  (IAGP)
abnormal ureteric bud elongation  (IAGP)
abnormal ureterovesical junction morphology  (IAGP)
abnormal utricle morphology  (IAGP)
abnormal vascular endothelial cell physiology  (IAGP)
abnormal vascular smooth muscle morphology  (IAGP)
abnormal vertebrae development  (IAGP)
abnormal vertebral arch development  (IAGP)
abnormal vertebral arch morphology  (IAGP)
abnormal vertebral body development  (IAGP)
abnormal vertebral spinous process morphology  (IAGP)
abnormal vestibular saccule morphology  (IAGP)
abnormal vestibulocollic reflex  (IAGP)
abnormal visceral yolk sac mesenchyme morphology  (IAGP)
abnormal visceral yolk sac morphology  (IAGP)
abnormal vitreous body morphology  (IAGP)
abnormal Wolffian duct morphology  (IAGP)
absent alisphenoid bone  (IAGP)
absent allantois  (IAGP)
absent frontal bone  (IAGP)
absent lateral semicircular canal  (IAGP)
absent mandible  (IAGP)
absent mandibular angle  (IAGP)
absent mandibular condyloid process  (IAGP)
absent mandibular coronoid process  (IAGP)
absent maxilla  (IAGP)
absent nasal bone  (IAGP)
absent nasal septum  (IAGP)
absent optic nerve  (IAGP)
absent primordial germ cells  (IAGP)
absent Rathke's pouch  (IAGP)
absent Schlemm's canal  (IAGP)
absent semicircular canals  (IAGP)
absent temporal bone squamous part  (IAGP)
absent tongue  (IAGP)
absent trabecular meshwork  (IAGP)
absent tympanic ring  (IAGP)
absent urinary bladder  (IAGP)
absent visceral yolk sac blood islands  (IAGP)
absent vitelline blood vessels  (IAGP)
absent zygomatic bone  (IAGP)
anal stenosis  (IAGP)
anophthalmia  (IAGP)
anterior cortical cataract  (IAGP)
anterior iris synechia  (IAGP)
anterior subcapsular cataract  (IAGP)
aortopulmonary window  (IAGP)
asymmetric rib joints  (IAGP)
atrial septal defect  (IAGP)
bifid ureter  (IAGP)
broad limb buds  (IAGP)
buphthalmos  (IAGP)
cataract  (IAGP)
cervical vertebral fusion  (IAGP)
circling  (IAGP)
cleft palate  (IAGP)
common atrioventricular valve  (IAGP)
complete atrioventricular septal defect  (IAGP)
conotruncal ridge hypoplasia  (IAGP)
corneal opacity  (IAGP)
decreased anxiety-related response  (IEA)
decreased body weight  (IAGP)
decreased cornea thickness  (IAGP)
decreased erythrocyte cell number  (IAGP)
decreased hair follicle number  (IAGP)
decreased lateral semicircular canal size  (IAGP)
decreased litter size  (IAGP)
decreased primordial germ cell number  (IAGP)
decreased retina inner nuclear layer thickness  (IAGP)
decreased rib number  (IAGP)
decreased total retina thickness  (IEA)
decreased tympanic ring size  (IAGP)
decreased vestibular hair cell stereocilia number  (IAGP)
delayed bone ossification  (IAGP)
delayed endochondral bone ossification  (IAGP)
delayed hepatic development  (IAGP)
dilated kidney calyx  (IAGP)
dilated ureter  (IAGP)
double outlet right ventricle  (IAGP)
duplex kidney  (IAGP)
ectopic ureter  (IAGP)
ectopic ureteric bud  (IAGP)
embryonic growth retardation  (IAGP)
embryonic lethality between implantation and somite formation, complete penetrance  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
embryonic lethality during organogenesis, incomplete penetrance  (IAGP)
embryonic lethality prior to tooth bud stage  (IEA)
embryonic lethality, complete penetrance  (IAGP)
enlarged kidney  (IAGP)
enlarged Meckel's cartilage  (IAGP)
external male genitalia hypoplasia  (IAGP)
eyelids fail to open  (IAGP)
failure of primitive streak formation  (IAGP)
failure of ventral body wall closure  (IAGP)
fused joints  (IAGP)
heart right ventricle hypertrophy  (IAGP)
holoprosencephaly  (IAGP)
hydronephrosis  (IAGP)
hydrops fetalis  (IAGP)
hydroureter  (IAGP)
hyperactivity  (IEA)
hypoplastic trabecular meshwork  (IAGP)
impaired hearing  (IAGP)
impaired osteoblast differentiation  (IAGP)
impaired skin barrier function  (IAGP)
increased circulating glucose level  (IAGP)
increased grip strength  (IEA)
increased metanephric mesenchyme apoptosis  (IAGP)
increased opacity of vitreous body  (IAGP)
increased or absent threshold for auditory brainstem response  (IAGP)
interrupted aortic arch  (IAGP)
iris hypoplasia  (IAGP)
irregularly shaped pupil  (IAGP)
kidney atrophy  (IAGP)
kidney cyst  (IAGP)
kinked tail  (IAGP)
large anterior fontanelle  (IAGP)
lethality throughout fetal growth and development, incomplete penetrance  (IAGP)
lowered ear position  (IAGP)
microphthalmia  (IAGP)
mydriasis  (IAGP)
no abnormal phenotype detected  (IAGP)
ocular hypertension  (IAGP)
omphalocele  (IAGP)
oral atresia  (IAGP)
ostium primum atrial septal defect  (IAGP)
partial atrioventricular septal defect  (IAGP)
pericardial edema  (IAGP)
pericardial effusion  (IAGP)
perimembraneous ventricular septal defect  (IAGP)
perinatal lethality  (IAGP)
perinatal lethality, complete penetrance  (IAGP)
perinatal lethality, incomplete penetrance  (IAGP)
persistence of hyaloid vascular system  (IAGP)
persistent truncus arteriosis  (IAGP)
polycystic kidney  (IAGP)
polydactyly  (IAGP)
postnatal lethality  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
preaxial polydactyly  (IAGP)
prenatal lethality  (IAGP)
prenatal lethality, complete penetrance  (IAGP)
prenatal lethality, incomplete penetrance  (IAGP)
preweaning lethality, complete penetrance  (IEA)
reduced female fertility  (IAGP)
renal hypoplasia  (IAGP)
retina detachment  (IAGP)
retrognathia  (IAGP)
rib fusion  (IAGP)
round head  (IAGP)
seminiferous tubule degeneration  (IAGP)
short face  (IAGP)
short frontal bone  (IAGP)
short mandible  (IAGP)
short maxilla  (IAGP)
short nasal bone  (IAGP)
short ribs  (IAGP)
short tail  (IAGP)
single external naris  (IAGP)
single kidney  (IAGP)
sirenomelia  (IAGP)
small alisphenoid bone  (IAGP)
small allantois  (IAGP)
small frontal bone  (IAGP)
small interparietal bone  (IAGP)
small kidney  (IAGP)
small mandibular coronoid process  (IAGP)
small nasal bone  (IAGP)
small temporal bone squamous part  (IAGP)
small testis  (IAGP)
small vertebral body  (IAGP)
small zygomatic bone  (IAGP)
split xiphoid process  (IAGP)
syndactyly  (IAGP)
thick myocardium  (IAGP)
thin retina ganglion layer  (IAGP)
thoracic vertebral fusion  (IAGP)
References

References - curated
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68. BMP4 mediates oxidative stress-induced retinal pigment epithelial cell senescence and is overexpressed in age-related macular degeneration. Zhu D, etal., J Biol Chem. 2009 Apr 3;284(14):9529-39. doi: 10.1074/jbc.M809393200. Epub 2009 Jan 21.
Additional References at PubMed
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PMID:9570771   PMID:9584130   PMID:9585504   PMID:9620855   PMID:9655803   PMID:9664685   PMID:9664686   PMID:9689088   PMID:9707326   PMID:9716414   PMID:9729491   PMID:9731531  
PMID:9731532   PMID:9732271   PMID:9733575   PMID:9768360   PMID:9768363   PMID:9786991   PMID:9797472   PMID:9799237   PMID:9799429   PMID:9806931   PMID:9811582   PMID:9847236  
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