Atp7b (ATPase, Cu++ transporting, beta polypeptide) - Rat Genome Database

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Gene: Atp7b (ATPase, Cu++ transporting, beta polypeptide) Mus musculus
Analyze
Symbol: Atp7b
Name: ATPase, Cu++ transporting, beta polypeptide
RGD ID: 10217
MGI Page MGI
Description: Enables P-type divalent copper transporter activity. Acts upstream of or within several processes, including intracellular monoatomic cation homeostasis; lactation; and protein maturation by copper ion transfer. Located in membrane and trans-Golgi network. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Used to study Wilson disease. Human ortholog(s) of this gene implicated in Wilson disease. Orthologous to human ATP7B (ATPase copper transporting beta).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: At; Atp7a; copper pump 2; copper-transporting ATPase 2; toxic milk; tx; wilson disease-associated protein homolog; Wilson protein; WN; WND
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39822,482,799 - 22,550,347 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl822,482,801 - 22,550,321 (-)EnsemblGRCm39 Ensembl
GRCm38821,992,783 - 22,060,074 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl821,992,785 - 22,060,305 (-)EnsemblGRCm38mm10GRCm38
MGSCv37823,104,820 - 23,170,546 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36823,459,893 - 23,525,619 (-)NCBIMGSCv36mm8
Celera823,490,671 - 23,556,555 (-)NCBICelera
Cytogenetic Map8A2NCBI
cM Map810.78NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
1,1'-azobis(N,N-dimethylformamide)  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,6-dinitrotoluene  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
ATP  (ISO)
atrazine  (ISO)
bathocuproine disulfonic acid  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (ISO)
beta-hexachlorocyclohexane  (EXP)
beta-naphthoflavone  (ISO)
bisphenol A  (EXP,ISO)
brefeldin A  (ISO)
buta-1,3-diene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carboplatin  (ISO)
chloroprene  (EXP)
chlorpyrifos  (EXP)
cholesterol  (ISO)
cisplatin  (EXP,ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
CU-O LINKAGE  (ISO)
cyclosporin A  (ISO)
cytarabine  (ISO)
D-penicillamine  (EXP,ISO)
decabromodiphenyl ether  (ISO)
dichlorine  (ISO)
dimethylarsinic acid  (EXP)
dioxygen  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
epoxiconazole  (EXP)
ferroheme b  (ISO)
folic acid  (ISO)
FR900359  (ISO)
genistein  (ISO)
glutathione  (ISO)
glycidol  (ISO)
glycine betaine  (EXP)
GW 4064  (EXP)
heme b  (ISO)
hydrogen peroxide  (ISO)
inulin  (EXP)
iron atom  (ISO)
iron(0)  (ISO)
lead(0)  (ISO)
luteolin  (ISO)
magnesium atom  (ISO)
malonaldehyde  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
menadione  (ISO)
methapyrilene  (ISO)
methoxychlor  (ISO)
methylarsonic acid  (EXP)
methylmercury chloride  (ISO)
monosodium L-glutamate  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (ISO)
nickel atom  (ISO)
nitrofen  (ISO)
nocodazole  (ISO)
oxaliplatin  (ISO)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
pentachlorophenol  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
platinum  (EXP)
platinum(0)  (EXP)
potassium chromate  (ISO)
progesterone  (ISO)
protoporphyrin  (ISO)
quercetin  (ISO)
S-adenosyl-L-homocysteine  (EXP)
S-adenosyl-L-methioninate  (EXP)
S-adenosyl-L-methionine  (EXP)
satraplatin  (EXP)
SB 431542  (ISO)
sodium arsenate  (EXP)
sodium arsenite  (EXP,ISO)
streptozocin  (ISO)
tetrachloromethane  (ISO)
tetrathiomolybdate(2-)  (EXP,ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
trichloroethene  (ISO)
triclosan  (ISO)
tunicamycin  (EXP)
valproic acid  (ISO)
vinclozolin  (ISO)
zinc acetate  (EXP)
zinc atom  (EXP)
zinc dichloride  (ISO)
zinc sulfate  (ISO)
zinc(0)  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Expression of copper-transporting P-type adenosine triphosphatase (ATP7B) as a prognostic factor in human endometrial carcinoma. Aida T, etal., Gynecol Oncol. 2005 Apr;97(1):41-5.
2. Dominant-stable beta-catenin expression causes cell fate alterations and Wnt signaling antagonist expression in a murine granulosa cell tumor model. Boerboom D, etal., Cancer Res. 2006 Feb 15;66(4):1964-73.
3. Therapeutic potential of hepatocyte-like-cells converted from stem cells from human exfoliated deciduous teeth in fulminant Wilson's disease. Fujiyoshi J, etal., Sci Rep. 2019 Feb 7;9(1):1535. doi: 10.1038/s41598-018-38275-y.
4. Copper-transporting P-type adenosine triphosphatase (ATP7B) is expressed in human breast carcinoma. Kanzaki A, etal., Jpn J Cancer Res. 2002 Jan;93(1):70-7.
5. Abnormal hepatobiliary and circulating lipid metabolism in the Long-Evans Cinnamon rat model of Wilson's disease. Levy E, etal., Life Sci. 2007 Mar 27;80(16):1472-83. Epub 2007 Jan 20.
6. Hereditary hepatitis of LEC rats is controlled by a single autosomal recessive gene. Masuda R, etal., Lab Anim. 1988 Apr;22(2):166-9. doi: 10.1258/002367788780864402.
7. Restoration of copper metabolism and rescue of hepatic abnormalities in LEC rats, an animal model of Wilson disease, by expression of human ATP7B gene. Meng Y, etal., Biochim Biophys Acta 2004 Nov 5;1690(3):208-19.
8. Lentiviral gene transfer ameliorates disease progression in Long-Evans cinnamon rats: an animal model for Wilson disease. Merle U, etal., Scand J Gastroenterol. 2006 Aug;41(8):974-82. doi: 10.1080/00365520600554790.
9. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
10. MGDs mouse GO annotations MGD data from the GO Consortium
11. MGD IEA MGD IEA
12. Role of Atp7b gene in spontaneous and N-diethylnitrosamine-induced carcinogenesis in a new congenic strain, WKAH.C-Atp7b rats. Minami T, etal., Jpn J Cancer Res 2001 Aug;92(8):841-7.
13. The LEC rat: a model for human hepatitis, liver cancer, and much more. Mori M, etal., Am J Pathol. 1994 Jan;144(1):200-4.
14. Copper-transporting P-type adenosine triphosphatase (ATP7B) as a cisplatin based chemoresistance marker in ovarian carcinoma: comparative analysis with expression of MDR1, MRP1, MRP2, LRP and BCRP. Nakayama K, etal., Int J Cancer. 2002 Oct 10;101(5):488-95.
15. Inherited copper toxicity in Long-Evans cinnamon rats exhibiting spontaneous hepatitis: a model of Wilson's disease. Okayasu T, etal., Pediatr Res. 1992 Mar;31(3):253-7. doi: 10.1203/00006450-199203000-00011.
16. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
17. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
18. Mouse MP Annotation Import Pipeline RGD automated import pipeline
19. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. Subcellular targets of cisplatin cytotoxicity: an integrated view. Sancho-Martinez SM, etal., Pharmacol Ther. 2012 Oct;136(1):35-55. doi: 10.1016/j.pharmthera.2012.07.003. Epub 2012 Jul 14.
22. The gene responsible for LEC hepatitis, located on rat chromosome 16, is the homolog to the human Wilson disease gene. Sasaki N, etal., Biochem Biophys Res Commun 1994 Jul 15;202(1):512-8.
23. Evolution of exchangeable copper and relative exchangeable copper through the course of Wilson's disease in the Long Evans Cinnamon rat. Schmitt F, etal., PLoS One. 2013 Dec 17;8(12):e82323. doi: 10.1371/journal.pone.0082323. eCollection 2013.
24. Genetics of Wilson disease and Wilson-like phenotype in a clinical series from eastern Spain. Sánchez-Monteagudo A, etal., Clin Genet. 2020 Feb 11. doi: 10.1111/cge.13719.
25. The LEC rat has a deletion in the copper transporting ATPase gene homologous to the Wilson disease gene. Wu J, etal., Nat Genet 1994 Aug;7(4):541-5.
26. New mutation causing hereditary hepatitis in the laboratory rat. Yoshida MC, etal., J Hered 1987 Nov-Dec;78(6):361-5.
Additional References at PubMed
PMID:1588441   PMID:2845190   PMID:6863890   PMID:7490097   PMID:7979235   PMID:7998953   PMID:8040371   PMID:8082762   PMID:8128500   PMID:8257436   PMID:8666408   PMID:8732640  
PMID:8894697   PMID:8921375   PMID:9020864   PMID:9215673   PMID:9392450   PMID:9484715   PMID:9823011   PMID:10441329   PMID:11085952   PMID:11237756   PMID:11668395   PMID:12372948  
PMID:12644567   PMID:12718440   PMID:14617772   PMID:14651853   PMID:14681479   PMID:15634671   PMID:16436657   PMID:16745972   PMID:16785251   PMID:17205981   PMID:17910951   PMID:17928409  
PMID:17981064   PMID:18000748   PMID:18180385   PMID:19021531   PMID:19141620   PMID:20433422   PMID:21242307   PMID:21267068   PMID:21327972   PMID:21517843   PMID:21677750   PMID:21873635  
PMID:21997183   PMID:22130675   PMID:22308360   PMID:22565294   PMID:22629446   PMID:22802922   PMID:24831241   PMID:25594375   PMID:25634697   PMID:25704483   PMID:26241054   PMID:27034138  
PMID:28428350   PMID:28820536   PMID:29732486   PMID:29945887   PMID:30010856   PMID:30341172   PMID:30890638   PMID:30973228   PMID:31011744   PMID:31668086   PMID:31924743   PMID:32325033  
PMID:33462188   PMID:33707579   PMID:33935715   PMID:34627751   PMID:36626371   PMID:37707949   PMID:38072238  


Genomics

Comparative Map Data
Atp7b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39822,482,799 - 22,550,347 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl822,482,801 - 22,550,321 (-)EnsemblGRCm39 Ensembl
GRCm38821,992,783 - 22,060,074 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl821,992,785 - 22,060,305 (-)EnsemblGRCm38mm10GRCm38
MGSCv37823,104,820 - 23,170,546 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36823,459,893 - 23,525,619 (-)NCBIMGSCv36mm8
Celera823,490,671 - 23,556,555 (-)NCBICelera
Cytogenetic Map8A2NCBI
cM Map810.78NCBI
ATP7B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381351,932,669 - 52,012,132 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1351,930,436 - 52,012,125 (-)EnsemblGRCh38hg38GRCh38
GRCh371352,506,805 - 52,585,586 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361351,404,806 - 51,483,631 (-)NCBINCBI36Build 36hg18NCBI36
Build 341351,404,805 - 51,483,631NCBI
Celera1333,555,444 - 33,634,269 (-)NCBICelera
Cytogenetic Map13q14.3NCBI
HuRef1333,295,317 - 33,374,147 (-)NCBIHuRef
CHM1_11352,473,433 - 52,553,190 (-)NCBICHM1_1
T2T-CHM13v2.01351,147,339 - 51,226,948 (-)NCBIT2T-CHM13v2.0
Atp7b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81676,654,725 - 76,726,092 (+)NCBIGRCr8
mRatBN7.21669,952,286 - 70,024,404 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1669,951,778 - 70,023,636 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1675,225,956 - 75,297,317 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01678,664,533 - 78,736,202 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01673,913,825 - 73,985,530 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01674,865,516 - 74,944,935 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1674,865,516 - 74,945,286 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01674,495,179 - 74,575,822 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41674,607,988 - 74,680,080 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11674,608,239 - 74,679,614 (+)NCBI
Celera1667,837,288 - 67,908,140 (+)NCBICelera
RH 3.4 Map16664.21RGD
Cytogenetic Map16q12.5NCBI
Atp7b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554315,229,126 - 5,269,616 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554315,228,395 - 5,297,120 (-)NCBIChiLan1.0ChiLan1.0
ATP7B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21453,366,970 - 53,447,808 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11352,012,774 - 52,091,309 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01333,063,698 - 33,144,528 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11351,808,491 - 51,888,488 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1351,810,555 - 51,851,839 (-)Ensemblpanpan1.1panPan2
ATP7B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.122162,474 - 225,599 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl22191,888 - 225,266 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha22227,530 - 260,908 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.022144,381 - 208,578 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl22163,718 - 208,552 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12295,838 - 129,431 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.022145,387 - 179,042 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.022163,429 - 197,022 (+)NCBIUU_Cfam_GSD_1.0
Atp7b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945161,210,231 - 161,278,988 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365654,694,281 - 4,763,773 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365654,694,294 - 4,763,661 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ATP7B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1115,876,612 - 15,942,064 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11115,892,549 - 15,942,070 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21116,218,277 - 16,263,614 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ATP7B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1329,817,712 - 29,899,302 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl329,816,860 - 29,899,077 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605713,915,907 - 13,997,411 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Atp7b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247482,113,094 - 2,205,856 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247482,112,574 - 2,183,994 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Atp7b
2753 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1450
Count of miRNA genes:672
Interacting mature miRNAs:840
Transcripts:ENSMUST00000006742, ENSMUST00000110738
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13432571Scvg1_msubcutaneous vessel growth QTL 1 (mouse)8124751082Mouse
11533914Mts5_mmammary tumor susceptibility 5 (mouse)8130447432Mouse
4140978Nilac5_mnicotine induced locomotor activity 5 (mouse)Not determined8131773288Mouse
27226756Femd2_mfemur midshaft diameter 2, 5 week (mouse)8495000035067154Mouse
1357525Pnhdlc3_mplasma non-HDL cholesterol 3 (mouse)Not determined8721249923753815Mouse
1301532Scc8_mcolon tumor susceptibility 8 (mouse)Not determined8721249935110107Mouse
1300906Ap8q_malcohol preference 8 QTL (mouse)Not determined8798418941984342Mouse
10412209Cypr7_mcytokine production 7 (mouse)Not determined8810320142103372Mouse
1301929Eae24_msusceptibility to experimental allergic encephalomyelitis 24 (mouse)Not determined8810320142103372Mouse
1301128Sluc20_msusceptibility to lung cancer 20 (mouse)Not determined8810320142103372Mouse
11532713Sluc42_msusceptibility to lung cancer 42 (mouse)81344721035321225Mouse
1558870Eae36_mexperimental allergic encephalomyelitis susceptibility 36 (mouse)Not determined81477316071498244Mouse
1301088Alcw6_malcohol withdrawal 6 (mouse)Not determined81550657249506729Mouse
1300912Daq19_mdirectional asymmetry QTL 19 (mouse)Not determined81550657249506729Mouse
1301298Pgia4_mproteoglycan induced arthritis 4 (mouse)Not determined81656937350569697Mouse
4142199Poats1_mpost-ovarectomy adrenal tumor susceptibility 1 (mouse)Not determined1708262628849467Mouse
1301550Fembrs2_mfemur breaking strength 2 (mouse)Not determined81832109752321225Mouse
1301160Eae14_msusceptibility to experimental allergic encephalomyelitis 14 (mouse)Not determined81945501853455150Mouse
1300603Cd8ts2_mCD8 T cell subset 2 (mouse)Not determined81945501853455150Mouse

Markers in Region
Atp7b  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38822,027,822 - 22,028,679UniSTSGRCm38
MGSCv37823,138,294 - 23,139,151UniSTSGRCm37
Celera823,524,141 - 23,524,998UniSTS
Cytogenetic Map8A2UniSTS
cM Map810.0UniSTS


Expression


Sequence


RefSeq Acc Id: ENSMUST00000006742   ⟹   ENSMUSP00000006742
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl822,482,801 - 22,550,321 (-)Ensembl
GRCm38.p6 Ensembl821,992,785 - 22,060,305 (-)Ensembl
RefSeq Acc Id: ENSMUST00000110738   ⟹   ENSMUSP00000106366
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl822,484,667 - 22,550,035 (-)Ensembl
GRCm38.p6 Ensembl821,994,651 - 22,060,019 (-)Ensembl
RefSeq Acc Id: NM_001403709   ⟹   NP_001390638
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39822,482,801 - 22,529,657 (-)NCBI
RefSeq Acc Id: NM_007511   ⟹   NP_031537
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39822,482,801 - 22,550,347 (-)NCBI
GRCm38821,994,348 - 22,060,074 (-)NCBI
MGSCv37823,104,820 - 23,170,546 (-)RGD
Celera823,490,671 - 23,556,555 (-)RGD
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_175403
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39822,482,801 - 22,550,347 (-)NCBI
RefSeq Acc Id: XM_011242119   ⟹   XP_011240421
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39822,499,801 - 22,529,929 (-)NCBI
GRCm38822,009,784 - 22,039,913 (-)NCBI
Sequence:
RefSeq Acc Id: XR_378777
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39822,482,799 - 22,529,929 (-)NCBI
GRCm38821,993,317 - 22,039,913 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001390638 (Get FASTA)   NCBI Sequence Viewer  
  NP_031537 (Get FASTA)   NCBI Sequence Viewer  
  XP_011240421 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL32910 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000006742
  ENSMUSP00000006742.5
  ENSMUSP00000106366.3
GenBank Protein Q64446 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_031537   ⟸   NM_007511
- Peptide Label: isoform 2
- UniProtKB: B1AQ56 (UniProtKB/Swiss-Prot),   Q64446 (UniProtKB/Swiss-Prot),   B1AQ57 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011240421   ⟸   XM_011242119
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSMUSP00000006742   ⟸   ENSMUST00000006742
RefSeq Acc Id: ENSMUSP00000106366   ⟸   ENSMUST00000110738
RefSeq Acc Id: NP_001390638   ⟸   NM_001403709
- Peptide Label: isoform 1
- UniProtKB: B1AQ57 (UniProtKB/TrEMBL)
Protein Domains
HMA

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q64446-F1-model_v2 AlphaFold Q64446 1-1462 view protein structure

Promoters
RGD ID:8666649
Promoter ID:EPDNEW_M11355
Type:multiple initiation site
Name:Atp7b_1
Description:Mus musculus ATPase, Cu++ transporting, beta polypeptide , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38822,060,042 - 22,060,102EPDNEW
RGD ID:6842818
Promoter ID:MM_KWN:53906
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000110738,   OTTMUST00000049244,   OTTMUST00000049251,   OTTMUST00000070570,   UC009LCM.1,   UC009LCN.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36823,170,476 - 23,171,312 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:103297 AgrOrtholog
Ensembl Genes ENSMUSG00000006567 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000006742 ENTREZGENE
  ENSMUST00000006742.11 UniProtKB/Swiss-Prot
  ENSMUST00000110738.3 UniProtKB/TrEMBL
Gene3D-CATH 3.30.70.100 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.1110.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.1000 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Calcium-transporting ATPase, cytoplasmic transduction domain A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ATPase_P-typ_cyto_dom_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATPase_P-typ_P_site UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATPase_P-typ_TM_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATPase_P-typ_transduc_dom_A_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HAD-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HAD_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Heavy-metal-associated_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HMA_Cu_ion-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HMA_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HMA_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-typ_ATPase_IB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P_typ_ATPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P_typ_ATPase_HD_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:11979 UniProtKB/Swiss-Prot
MGD MGI:103297 ENTREZGENE
NCBI Gene 11979 ENTREZGENE
PANTHER ATP7, ISOFORM B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  COPPER-TRANSPORTING ATPASE 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam E1-E2_ATPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HMA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hydrolase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB ATP7B RGD
PhenoGen Atp7b PhenoGen
PRINTS CATATPASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CUATPASEI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ATPASE_E1_E2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HMA_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HMA_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF55008 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56784 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF81653 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF81665 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt ATP7B_MOUSE UniProtKB/Swiss-Prot
  B1AQ56 ENTREZGENE
  B1AQ57 ENTREZGENE, UniProtKB/TrEMBL
  Q64446 ENTREZGENE
UniProt Secondary B1AQ56 UniProtKB/Swiss-Prot