Atp7a (ATPase, copper transporting, alpha polypeptide) - Rat Genome Database

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Gene: Atp7a (ATPase, copper transporting, alpha polypeptide) Mus musculus
Analyze
Symbol: Atp7a
Name: ATPase, copper transporting, alpha polypeptide
RGD ID: 10215
MGI Page MGI
Description: Enables P-type divalent copper transporter activity and superoxide dismutase copper chaperone activity. Involved in copper ion export and intracellular copper ion homeostasis. Acts upstream of or within several processes, including catecholamine metabolic process; erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process; and neuron differentiation. Located in several cellular components, including cytoplasmic vesicle membrane; neuronal cell body; and trans-Golgi network membrane. Is expressed in several structures, including genitourinary system; gut mucosa; liver; nervous system; and spleen. Used to study Menkes disease; X-linked distal spinal muscular atrophy 3; aortic aneurysm; and osteoarthritis. Human ortholog(s) of this gene implicated in Menkes disease; X-linked distal spinal muscular atrophy 3; cutis laxa; and occipital horn syndrome. Orthologous to human ATP7A (ATPase copper transporting alpha).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ATPase, Cu++ transporting, alpha polypeptide; b; Blo; blotchy; br; brindled; copper pump 1; copper-transporting ATPase 1; DXHXS1608e; I14; menkes disease-associated protein homolog; Menkes protein; MN; MNK; Mo; mottled
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Atp7a-rs1  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X105,070,830 - 105,171,766 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX105,070,882 - 105,168,532 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38X106,027,224 - 106,128,161 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX106,027,276 - 106,124,926 (+)Ensemblmm10GRCm38
MGSCv37X103,222,615 - 103,323,499 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36X102,230,036 - 102,327,636 (+)NCBIMGSCv36mm8
CeleraX92,880,992 - 92,982,185 (+)NCBICelera
Cytogenetic MapXDNCBI
cM MapX47.36NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1'-azobis(N,N-dimethylformamide)  (ISO)
1,1-dichloroethene  (EXP)
1,2-dimethylhydrazine  (EXP,ISO)
1,4-dithiothreitol  (ISO)
17alpha-ethynylestradiol  (EXP)
2,2,2-tetramine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxy-TEMPO  (EXP)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP,ISO)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
acetylcholine  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (ISO)
aristolochic acid A  (ISO)
arsenous acid  (EXP)
ATP  (ISO)
atrazine  (ISO)
Azoxymethane  (EXP)
bathocuproine disulfonic acid  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
brefeldin A  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
carboplatin  (ISO)
chloroprene  (ISO)
chromium(6+)  (ISO)
cisplatin  (EXP,ISO)
cobalt dichloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (EXP,ISO)
copper(II) sulfate  (ISO)
CU-O LINKAGE  (ISO)
cycloheximide  (ISO)
cyclosporin A  (EXP,ISO)
D-penicillamine  (ISO)
decabromodiphenyl ether  (ISO)
desferrioxamine B  (ISO)
dextran sulfate  (EXP)
diarsenic trioxide  (EXP)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
dioxygen  (EXP,ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
folic acid  (EXP)
FR900359  (ISO)
hexadecanoic acid  (ISO)
hydrogen peroxide  (ISO)
irinotecan  (ISO)
iron atom  (EXP,ISO)
iron(0)  (EXP,ISO)
ketamine  (ISO)
L-1,4-dithiothreitol  (ISO)
lead diacetate  (EXP,ISO)
lead(0)  (EXP)
lipopolysaccharide  (EXP)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
melanins  (ISO)
methapyrilene  (ISO)
methimazole  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
mithramycin  (ISO)
mitoxantrone  (ISO)
monensin A  (ISO)
N-ethylmaleimide  (ISO)
neocuproine  (EXP)
nitrofen  (ISO)
omeprazole  (EXP,ISO)
oxaliplatin  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP)
paraquat  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (EXP)
platinum  (EXP)
platinum(0)  (EXP)
potassium chromate  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
satraplatin  (EXP)
SB 431542  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (EXP,ISO)
silver monochloride  (EXP)
silver(0)  (EXP,ISO)
sodium arsenate  (EXP)
sodium arsenite  (EXP,ISO)
streptozocin  (EXP)
succimer  (EXP)
superoxide  (EXP)
tetrachloromethane  (EXP)
tetrathiomolybdate(2-)  (EXP)
thioacetamide  (ISO)
titanium dioxide  (EXP)
trichostatin A  (ISO)
troglitazone  (EXP)
tungsten  (EXP)
valproic acid  (EXP,ISO)
vincristine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
ATP metabolic process  (IMP)
blood vessel development  (IMP)
blood vessel remodeling  (IMP)
cartilage development  (IMP)
catecholamine metabolic process  (IMP)
cellular response to amino acid stimulus  (ISO)
cellular response to antibiotic  (ISO)
cellular response to cadmium ion  (ISO)
cellular response to cobalt ion  (ISO)
cellular response to copper ion  (ISO)
cellular response to hypoxia  (ISO)
cellular response to iron ion  (ISO)
cellular response to lead ion  (ISO)
cellular response to platelet-derived growth factor stimulus  (ISO)
central nervous system neuron development  (IMP)
cerebellar Purkinje cell differentiation  (IMP)
collagen fibril organization  (IMP)
copper ion export  (IBA,IEA,IMP,ISO,ISS)
copper ion import  (IBA,IMP)
copper ion transport  (IDA,IEA,IMP,ISO,ISS)
dendrite morphogenesis  (IMP)
detoxification of copper ion  (IMP)
dopamine metabolic process  (IMP)
elastic fiber assembly  (IMP)
epinephrine metabolic process  (IMP)
establishment of localization in cell  (IMP)
extracellular matrix organization  (IMP)
female pregnancy  (ISO)
glycoprotein biosynthetic process  (IMP)
hair follicle morphogenesis  (IMP)
hindlimb morphogenesis  (IMP)
in utero embryonic development  (ISO)
intracellular copper ion homeostasis  (IBA,IEA,IGI,IMP,ISO,ISS)
L-tryptophan metabolic process  (IMP)
lactation  (ISO)
liver development  (ISO)
locomotory behavior  (IMP)
lung alveolus development  (IMP)
mitochondrion organization  (IMP)
monoatomic cation transport  (IEA)
monoatomic ion transport  (IEA)
negative regulation of catecholamine metabolic process  (IMP)
negative regulation of iron ion transmembrane transport  (ISO)
negative regulation of neuron apoptotic process  (IMP)
neuron apoptotic process  (IMP)
neuron cellular homeostasis  (IMP)
neuron projection morphogenesis  (IMP)
norepinephrine biosynthetic process  (IMP)
norepinephrine metabolic process  (IMP)
peptidyl-lysine modification  (IMP)
pigmentation  (IMP)
positive regulation of catalytic activity  (IMP)
positive regulation of cell size  (ISO)
positive regulation of cytochrome-c oxidase activity  (IMP)
positive regulation of epithelial cell proliferation  (ISO)
positive regulation of lamellipodium assembly  (ISO)
positive regulation of melanin biosynthetic process  (IEA,ISO,ISS)
positive regulation of response to wounding  (ISO)
positive regulation of superoxide dismutase activity  (IMP)
positive regulation of vascular associated smooth muscle cell migration  (ISO)
pyramidal neuron development  (IMP)
regulation of cytochrome-c oxidase activity  (ISO)
regulation of gene expression  (IMP)
regulation of oxidative phosphorylation  (IMP)
release of cytochrome c from mitochondria  (IMP)
removal of superoxide radicals  (IMP)
response to copper ion  (IEA,ISO)
response to iron(III) ion  (ISO)
response to lead ion  (ISO)
response to manganese ion  (ISO)
response to zinc ion  (ISO)
serotonin metabolic process  (IMP)
skin development  (IMP)
T-helper cell differentiation  (IMP)
tyrosine metabolic process  (IMP)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal Ammon gyrus morphology  (IAGP)
abnormal aorta elastic fiber morphology  (IAGP)
abnormal aorta morphology  (IAGP)
abnormal autopod morphology  (IEA)
abnormal awl hair morphology  (IEA)
abnormal breathing pattern  (IAGP)
abnormal cartilage morphology  (IAGP)
abnormal cell morphology  (IAGP)
abnormal cell physiology  (IAGP)
abnormal cerebellar granule layer morphology  (IAGP)
abnormal cerebral cortex morphology  (IAGP)
abnormal coat appearance  (IEA)
abnormal coat/ hair morphology  (IEA)
abnormal coat/hair pigmentation  (IAGP)
abnormal copper homeostasis  (IAGP)
abnormal copper level  (IAGP)
abnormal cutaneous collagen fibril morphology  (IAGP)
abnormal enzyme/coenzyme activity  (IAGP)
abnormal frontonasal prominence morphology  (IAGP)
abnormal gait  (IAGP)
abnormal gonadal fat pad morphology  (IAGP)
abnormal hair shaft melanin granule morphology  (IEA)
abnormal hair shaft morphology  (IAGP)
abnormal hair texture  (IEA)
abnormal hindlimb morphology  (IEA)
abnormal ion homeostasis  (IAGP)
abnormal large intestine morphology  (IEA)
abnormal limb bone morphology  (IEA)
abnormal mitochondrial physiology  (IAGP)
abnormal motor capabilities/coordination/movement  (IAGP)
abnormal neuromuscular synapse morphology  (IAGP)
abnormal noradrenaline level  (IAGP)
abnormal pectoral girdle bone morphology  (IEA)
abnormal pelvic girdle bone morphology  (IEA)
abnormal pH regulation  (IAGP)
abnormal postnatal growth  (IAGP)
abnormal pulmonary alveolus morphology  (IAGP)
abnormal pulmonary interalveolar septum morphology  (IAGP)
abnormal Purkinje cell morphology  (IAGP)
abnormal renal tubule morphology  (IAGP)
abnormal respiratory system physiology  (IAGP)
abnormal rib morphology  (IEA)
abnormal skeletal muscle fiber morphology  (IAGP)
abnormal skeleton morphology  (IEA)
abnormal skin condition  (IAGP)
abnormal survival  (IEA)
abnormal tail bud morphology  (IAGP)
abnormal vertebrae morphology  (IEA)
abnormal vibrissa morphology  (IEA)
abnormal visceral yolk sac morphology  (IAGP)
abnormal vitelline vascular remodeling  (IAGP)
abnormal vitelline vasculature morphology  (IAGP)
abnormal vocalization  (IEA)
abnormal zigzag hair morphology  (IEA)
absent coat pigmentation  (IAGP)
absent vibrissae  (IEA)
aneurysm  (IAGP)
aortic aneurysm  (IAGP)
ataxia  (IAGP)
cachexia  (IAGP)
calcified tendon  (IEA)
clubfoot  (IEA)
coarse hair  (IAGP)
curly vibrissae  (IAGP)
decreased aorta elastin content  (IAGP)
decreased body size  (IAGP)
decreased brain copper level  (IAGP)
decreased brainstem copper level  (IEA)
decreased circulating ceruloplasmin level  (IEA)
decreased circulating copper level  (IAGP)
decreased copper level  (IEA)
decreased creatine kinase activity  (IAGP)
decreased creatine level  (IAGP)
decreased embryo size  (IAGP)
decreased grip strength  (IAGP)
decreased kidney weight  (IAGP)
decreased litter size  (IEA)
decreased liver copper level  (IAGP)
decreased locomotor activity  (IAGP)
decreased noradrenaline level  (IAGP)
decreased renal glomerulus number  (IAGP)
decreased skeletal muscle mass  (IAGP)
decreased skin tensile strength  (IAGP)
decreased spleen weight  (IEA)
decreased susceptibility to prion infection  (IAGP)
dilated aorta  (IAGP)
dilated ascending aorta  (IAGP)
dilated pulmonary alveolar duct  (IAGP)
dilated respiratory conducting tube  (IAGP)
diluted coat color  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
embryonic lethality during organogenesis, incomplete penetrance  (IAGP)
embryonic lethality, complete penetrance  (IAGP)
enlarged lung  (IAGP)
female infertility  (IEA)
hemoperitoneum  (IAGP)
hemorrhage  (IAGP)
hemothorax  (IAGP)
hindlimb paralysis  (IAGP)
hindlimb paresis  (IEA)
hunched posture  (IAGP)
hypopigmentation  (IAGP)
impaired balance  (IEA)
impaired coordination  (IAGP)
impaired limb coordination  (IEA)
increased aortic weight  (IAGP)
increased brain apoptosis  (IAGP)
increased brain copper level  (IAGP)
increased copper level  (IAGP)
increased intestine copper level  (IAGP)
increased kidney copper level  (IAGP)
increased lung compliance  (IAGP)
increased neuron apoptosis  (IAGP)
increased sensitivity to induced cell death  (IAGP)
increased skeletal muscle fiber diameter  (IAGP)
increased total lung capacity  (IAGP)
irregular coat pigmentation  (IEA)
kinked vibrissae  (IEA)
lethality throughout fetal growth and development  (IAGP)
lethality throughout fetal growth and development, incomplete penetrance  (IEA)
lethargy  (IAGP)
limb grasping  (IAGP)
male infertility  (IEA)
mosaic coat color  (IAGP)
motor neuron degeneration  (IAGP)
mottled coat  (IAGP)
muscular atrophy  (IAGP)
no abnormal phenotype detected  (IAGP)
osteoarthritis  (IAGP)
oxidative stress  (IAGP)
pale yolk sac  (IAGP)
pallor  (IAGP)
perinatal lethality, complete penetrance  (IEA)
perinatal lethality, incomplete penetrance  (IEA)
postnatal growth retardation  (IAGP)
postnatal lethality  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
premature death  (IAGP)
prenatal lethality  (IAGP)
prenatal lethality, complete penetrance  (IAGP)
prenatal lethality, incomplete penetrance  (IAGP)
preweaning lethality, complete penetrance  (IEA)
preweaning lethality, incomplete penetrance  (IEA)
priapism  (IAGP)
tonic seizures  (IAGP)
tremors  (IAGP)
variable depigmentation  (IEA)
variegated coat color  (IAGP)
waved hair  (IEA)
wavy vibrissae  (IAGP)
weight loss  (IEA)
wide ribs  (IEA)
References

References - curated
# Reference Title Reference Citation
1. Changes in copper metabolism in different compartments of the brain in rats with induced fibrillogenesis. Babich PS, etal., Bull Exp Biol Med. 2009 Aug;148(2):217-22.
2. Identification of differentially expressed genes in response to dietary iron deprivation in rat duodenum. Collins JF, etal., Am J Physiol Gastrointest Liver Physiol. 2005 May;288(5):G964-71. Epub 2005 Jan 6.
3. Similar splicing mutations of the Menkes/mottled copper-transporting ATPase gene in occipital horn syndrome and the blotchy mouse. Das S, etal., Am J Hum Genet. 1995 Mar;56(3):570-6.
4. Favorably skewed X-inactivation accounts for neurological sparing in female carriers of Menkes disease. Desai V, etal., Clin Genet. 2011 Feb;79(2):176-82. doi: 10.1111/j.1399-0004.2010.01451.x.
5. Molecular basis of the brindled mouse mutant (Mo(br)): a murine model of Menkes disease. Grimes A, etal., Hum Mol Genet. 1997 Jul;6(7):1037-42.
6. Investigation of iron metabolism in mice expressing a mutant Menke's copper transporting ATPase (Atp7a) protein with diminished activity (Brindled; Mo (Br) (/y) ). Gulec S and Collins JF, PLoS One. 2013 Jun 11;8(6):e66010. doi: 10.1371/journal.pone.0066010. Print 2013.
7. Loss of divalent metal transporter 1 (DMT1) function promotes brain copper accumulation and increases impulsivity. Han M, etal., J Neurochem. 2016 Jun 22. doi: 10.1111/jnc.13717.
8. Occipital horn syndrome and a mild Menkes phenotype associated with splice site mutations at the MNK locus. Kaler SG, etal., Nat Genet. 1994 Oct;8(2):195-202.
9. Missense mutations in the copper transporter gene ATP7A cause X-linked distal hereditary motor neuropathy. Kennerson ML, etal., Am J Hum Genet. 2010 Mar 12;86(3):343-52. doi: 10.1016/j.ajhg.2010.01.027. Epub 2010 Feb 18.
10. Order of loci on the X-chromosome of the mouse. Lyon MF Genet Res 1966 Feb;7(1):130-3.
11. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
12. MGDs mouse GO annotations MGD data from the GO Consortium
13. MGD IEA MGD IEA
14. Exon duplications in the ATP7A gene: frequency and transcriptional behaviour. Mogensen M, etal., Orphanet J Rare Dis. 2011 Nov 10;6:73. doi: 10.1186/1750-1172-6-73.
15. Twenty-five novel mutations including duplications in the ATP7A gene. Moizard MP, etal., Clin Genet. 2011 Mar;79(3):243-53. doi: 10.1111/j.1399-0004.2010.01461.x.
16. Similar splice-site mutations of the ATP7A gene lead to different phenotypes: classical Menkes disease or occipital horn syndrome. Moller LB, etal., Am J Hum Genet 2000 Apr;66(4):1211-20. Epub 2000 Mar 17.
17. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
18. Characterizing the molecular phenotype of an Atp7aT985I conditional knock in mouse model for X-linked distal hereditary motor neuropathy (dHMNX). Perez-Siles G, etal., Metallomics. 2016 Jun 13.
19. Constitutive skipping of alternatively spliced exon 10 in the ATP7A gene abolishes Golgi localization of the menkes protein and produces the occipital horn syndrome. Qi M and Byers PH, Hum Mol Genet. 1998 Mar;7(3):465-9.
20. Mouse MP Annotation Import Pipeline RGD automated import pipeline
21. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
22. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
23. Subcellular targets of cisplatin cytotoxicity: an integrated view. Sancho-Martinez SM, etal., Pharmacol Ther. 2012 Oct;136(1):35-55. doi: 10.1016/j.pharmthera.2012.07.003. Epub 2012 Jul 14.
24. Disruption of copper-dependent signaling pathway in the nitrofen-induced congenital diaphragmatic hernia. Takahashi T, etal., Pediatr Surg Int. 2015 Jan;31(1):31-5. doi: 10.1007/s00383-014-3620-9. Epub 2014 Oct 16.
25. Diabetic cardiomyopathy is associated with defective myocellular copper regulation and both defects are rectified by divalent copper chelation. Zhang S, etal., Cardiovasc Diabetol. 2014 Jun 14;13:100. doi: 10.1186/1475-2840-13-100.
Additional References at PubMed
PMID:14140   PMID:17511   PMID:20889   PMID:27591   PMID:187892   PMID:205481   PMID:564942   PMID:571007   PMID:571898   PMID:573617   PMID:573618   PMID:573619  
PMID:937819   PMID:1115218   PMID:1694232   PMID:1752214   PMID:1779648   PMID:1819648   PMID:1912099   PMID:2055107   PMID:2288383   PMID:2473662   PMID:2474492   PMID:2793182  
PMID:2899541   PMID:3209066   PMID:3243423   PMID:3385878   PMID:3564905   PMID:3571489   PMID:3674914   PMID:3678930   PMID:4147174   PMID:4399067   PMID:4405722   PMID:4435359  
PMID:4561716   PMID:4670054   PMID:4808708   PMID:4858102   PMID:5361553   PMID:5367374   PMID:5452809   PMID:6441865   PMID:6462245   PMID:6542992   PMID:6583703   PMID:6644305  
PMID:6670991   PMID:6685755   PMID:6870774   PMID:7024043   PMID:7130053   PMID:7195926   PMID:7197928   PMID:7333461   PMID:7509170   PMID:7552582   PMID:7681531   PMID:7688531  
PMID:7704239   PMID:7726911   PMID:7769737   PMID:7805729   PMID:7873696   PMID:7959788   PMID:8009964   PMID:8025644   PMID:8054976   PMID:8054977   PMID:8081002   PMID:8082762  
PMID:8096378   PMID:8118102   PMID:8174230   PMID:8245411   PMID:8419320   PMID:8434133   PMID:8490646   PMID:8490647   PMID:8490656   PMID:8490659   PMID:8550574   PMID:8640230  
PMID:8661696   PMID:8672124   PMID:8732640   PMID:8740228   PMID:8889551   PMID:8895222   PMID:8921375   PMID:9090377   PMID:9147645   PMID:9147646   PMID:9166584   PMID:9207785  
PMID:9215673   PMID:9321757   PMID:9342151   PMID:9352491   PMID:9358851   PMID:9380433   PMID:9385451   PMID:9392450   PMID:9587146   PMID:9686356   PMID:9687544   PMID:9721210  
PMID:9823011   PMID:9831461   PMID:10098864   PMID:10332039   PMID:10349636   PMID:10587581   PMID:10632785   PMID:10720569   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11311799  
PMID:11386751   PMID:11391006   PMID:11534785   PMID:12056625   PMID:12372948   PMID:12466851   PMID:12477932   PMID:12488345   PMID:12520002   PMID:12620994   PMID:12904583   PMID:13103353  
PMID:13227156   PMID:13764598   PMID:14248461   PMID:14610273   PMID:15159688   PMID:15356208   PMID:15634671   PMID:15634787   PMID:16141072   PMID:16141073   PMID:16317117   PMID:16338116  
PMID:16371425   PMID:16461637   PMID:16488577   PMID:16590413   PMID:16750487   PMID:17003121   PMID:17045330   PMID:17215139   PMID:17248765   PMID:17483305   PMID:17588765   PMID:17928409  
PMID:17967808   PMID:18000748   PMID:18650808   PMID:18768397   PMID:18799693   PMID:19058563   PMID:19351718   PMID:19375486   PMID:19571810   PMID:19627984   PMID:19799774   PMID:19808669  
PMID:19965596   PMID:20084666   PMID:20594231   PMID:20671235   PMID:20831904   PMID:20849226   PMID:21267068   PMID:21336677   PMID:21471155   PMID:21677750   PMID:21873635   PMID:21878905  
PMID:22089129   PMID:22130675   PMID:22573614   PMID:22815746   PMID:22869751   PMID:22900086   PMID:23064757   PMID:23281160   PMID:23604539   PMID:23884884   PMID:24614111   PMID:24744874  
PMID:25247420   PMID:25456742   PMID:25639447   PMID:26269458   PMID:26437801   PMID:26496610   PMID:27226607   PMID:27337370   PMID:28219768   PMID:28820536   PMID:28931909   PMID:28973536  
PMID:29301787   PMID:29333545   PMID:29397366   PMID:29579719   PMID:30146317   PMID:30341172   PMID:30713523   PMID:31396659   PMID:31554420   PMID:32381719   PMID:32398691   PMID:32936699  
PMID:32968282   PMID:34035268   PMID:36232742   PMID:38355793  


Genomics

Comparative Map Data
Atp7a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X105,070,830 - 105,171,766 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX105,070,882 - 105,168,532 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38X106,027,224 - 106,128,161 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX106,027,276 - 106,124,926 (+)Ensemblmm10GRCm38
MGSCv37X103,222,615 - 103,323,499 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36X102,230,036 - 102,327,636 (+)NCBIMGSCv36mm8
CeleraX92,880,992 - 92,982,185 (+)NCBICelera
Cytogenetic MapXDNCBI
cM MapX47.36NCBI
ATP7A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X77,910,693 - 78,050,395 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX77,910,690 - 78,050,395 (+)Ensemblhg38GRCh38
GRCh37X77,166,190 - 77,305,892 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X77,052,876 - 77,192,208 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34X76,972,343 - 77,111,584NCBI
CeleraX77,407,059 - 77,546,975 (+)NCBICelera
Cytogenetic MapXq21.1NCBI
HuRefX70,752,187 - 70,892,316 (+)NCBIHuRef
CHM1_1X77,058,882 - 77,198,586 (+)NCBICHM1_1
T2T-CHM13v2.0X76,345,749 - 76,485,475 (+)NCBIT2T-CHM13v2.0
Atp7a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X75,159,635 - 75,267,094 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX75,159,782 - 75,267,093 (+)EnsemblGRCr8
mRatBN7.2X71,094,144 - 71,201,550 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX71,094,202 - 71,198,354 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX72,646,905 - 72,707,290 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X76,147,215 - 76,207,599 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X73,710,399 - 73,770,782 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X77,076,085 - 77,193,644 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX77,076,106 - 77,193,644 (+)Ensemblrn6Rnor6.0
Rnor_5.0X56,198,947 - 56,313,382 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X94,192,540 - 94,249,776 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX72,450,404 - 72,510,070 (+)NCBICelera
RGSC_v3.1X94,265,972 - 94,323,206 (+)NCBI
Cytogenetic MapXq22NCBI
Atp7a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555571,355,397 - 1,515,393 (+)Ensembl
ChiLan1.0NW_0049555571,355,471 - 1,515,725 (+)NCBIChiLan1.0ChiLan1.0
ATP7A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X77,492,788 - 77,630,493 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X77,496,415 - 77,634,104 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X67,093,675 - 67,231,318 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X77,205,579 - 77,342,762 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX77,255,312 - 77,342,756 (+)EnsemblpanPan2panpan1.1
ATP7A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X60,203,336 - 60,356,525 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX60,203,270 - 60,352,869 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_TashaX51,216,457 - 51,369,626 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0X61,442,067 - 61,595,242 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX61,442,069 - 61,592,549 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X59,148,063 - 59,301,397 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X60,758,474 - 60,911,162 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X60,346,304 - 60,499,464 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Atp7a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X42,009,558 - 42,154,264 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366832,874,042 - 2,935,040 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366832,874,022 - 2,936,214 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ATP7A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX61,972,991 - 62,110,048 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1X61,972,544 - 62,110,058 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X70,891,299 - 71,026,996 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ATP7A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X66,843,519 - 66,985,655 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX66,843,558 - 66,985,709 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366606714,518,402 - 14,662,927 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Atp7a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248362,808,681 - 2,993,452 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248362,804,349 - 3,058,125 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Atp7a
2444 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:351
Count of miRNA genes:199
Interacting mature miRNAs:208
Transcripts:ENSMUST00000055941, ENSMUST00000113557, ENSMUST00000133875, ENSMUST00000134363
Prediction methods:Miranda, Pita, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4141630Gct6_mgranulosa cell tumorigenesis 6 (mouse)Not determined47179121129764756Mouse
13208552Wght12_mweight 12 (mouse)X94043606149782996Mouse
4141803Lmr30_mleishmaniasis resistance 30 (mouse)Not determined85062606119062720Mouse
13208556Lgth14_mbody length 14 (mouse)X94043606149782996Mouse
13824980Ferq1_mgenetic fertility QTL 1 (mouse)X54045360148782996Mouse
11075102Modc2_mmodifier of Odc2 (mouse)X80189914114190059Mouse
1357500Mdmsc6_mmodifier of muscularity 6 (mouse)Not determinedX75306671109306758Mouse
1357823Spha3_msperm head anomaly 3 (mouse)Not determinedX102055848162758941Mouse
1357433Dbts2_mdiabetes 2 (mouse)Not determinedX7226295150107038Mouse
4141665Mhysq2_mmale hybrid sterility QTL 2 (mouse)Not determined71453852139203212Mouse

Markers in Region
UniSTS:238066  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X106,101,272 - 106,101,677UniSTSGRCm38
MGSCv37X103,296,611 - 103,297,016UniSTSGRCm37
CeleraX92,955,268 - 92,955,673UniSTS
Cytogenetic MapXDUniSTS
cM MapX44.0UniSTS
px-61g11  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X106,083,675 - 106,083,783UniSTSGRCm38
MGSCv37X103,279,014 - 103,279,122UniSTSGRCm37
CeleraX92,937,915 - 92,938,023UniSTS
Cytogenetic MapXDUniSTS
cM MapX44.0UniSTS
px-7f1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv37X103,292,132 - 103,292,331UniSTSGRCm37
MGSCv37X103,292,132 - 103,292,275UniSTSGRCm37
CeleraX92,950,509 - 92,950,765UniSTS
CeleraX92,950,509 - 92,950,652UniSTS
CeleraX92,950,509 - 92,950,708UniSTS
CeleraX92,950,972 - 92,951,171UniSTS
CeleraX92,950,972 - 92,951,115UniSTS
Cytogenetic MapXDUniSTS
cM MapX44.0UniSTS
Atp7a  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv37X103,292,121 - 103,292,757UniSTSGRCm37
CeleraX92,950,961 - 92,951,597UniSTS
CeleraX92,950,498 - 92,951,597UniSTS
Cytogenetic MapXDUniSTS
cM MapX44.0UniSTS
cM MapX44.0UniSTS
Atp7a  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X106,096,782 - 106,097,418UniSTSGRCm38
MGSCv37X103,292,121 - 103,292,757UniSTSGRCm37
CeleraX92,950,961 - 92,951,597UniSTS
CeleraX92,950,498 - 92,951,597UniSTS
Cytogenetic MapXDUniSTS
cM MapX44.0UniSTS
Atp7a  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic MapXDUniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001109757 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_009726 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB007134 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF486271 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK017506 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK030847 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK033254 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK036939 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK040753 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK155643 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK171563 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK172209 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL672288 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY011397 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC141395 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466564 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC124880 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U03434 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U03736 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U71091 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U95086 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000055941   ⟹   ENSMUSP00000058840
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX105,070,928 - 105,168,532 (+)Ensembl
GRCm38.p6 EnsemblX106,027,322 - 106,124,926 (+)Ensembl
Ensembl Acc Id: ENSMUST00000113557   ⟹   ENSMUSP00000109186
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX105,070,882 - 105,168,523 (+)Ensembl
GRCm38.p6 EnsemblX106,027,276 - 106,124,917 (+)Ensembl
Ensembl Acc Id: ENSMUST00000133875
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX105,158,843 - 105,166,051 (+)Ensembl
GRCm38.p6 EnsemblX106,115,237 - 106,122,445 (+)Ensembl
Ensembl Acc Id: ENSMUST00000134363
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX105,150,538 - 105,161,915 (+)Ensembl
GRCm38.p6 EnsemblX106,106,932 - 106,118,309 (+)Ensembl
RefSeq Acc Id: NM_001109757   ⟹   NP_001103227
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X105,070,830 - 105,171,766 (+)NCBI
GRCm38X106,027,224 - 106,128,160 (+)NCBI
MGSCv37X103,222,615 - 103,323,499 (+)RGD
CeleraX92,880,940 - 92,982,185 (+)NCBI
cM MapX ENTREZGENE
Sequence:
RefSeq Acc Id: NM_009726   ⟹   NP_033856
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X105,070,830 - 105,171,766 (+)NCBI
GRCm38X106,027,224 - 106,128,160 (+)NCBI
MGSCv37X103,222,615 - 103,323,499 (+)RGD
CeleraX92,880,940 - 92,982,185 (+)NCBI
cM MapX ENTREZGENE
Sequence:
RefSeq Acc Id: NP_033856   ⟸   NM_009726
- Peptide Label: isoform 2
- UniProtKB: P97422 (UniProtKB/Swiss-Prot),   O35101 (UniProtKB/Swiss-Prot),   A2AG69 (UniProtKB/Swiss-Prot),   Q64431 (UniProtKB/Swiss-Prot),   Q64430 (UniProtKB/Swiss-Prot),   B9EJ97 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001103227   ⟸   NM_001109757
- Peptide Label: isoform 1
- UniProtKB: A2AG68 (UniProtKB/TrEMBL),   B9EJ97 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000109186   ⟸   ENSMUST00000113557
Ensembl Acc Id: ENSMUSP00000058840   ⟸   ENSMUST00000055941
Protein Domains
HMA

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q64430-F1-model_v2 AlphaFold Q64430 1-1491 view protein structure

Promoters
RGD ID:6845501
Promoter ID:MM_KWN:61515
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_001109757,   NM_009726,   UC009UBM.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36X103,221,791 - 103,222,827 (+)MPROMDB
RGD ID:13681182
Promoter ID:EPDNEW_M24740
Type:initiation region
Name:Atp7a_1
Description:Mus musculus ATPase, Cu++ transporting, alpha polypeptide , transcriptvariant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M24741  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38X106,027,276 - 106,027,336EPDNEW
RGD ID:13681184
Promoter ID:EPDNEW_M24741
Type:multiple initiation site
Name:Atp7a_2
Description:Mus musculus ATPase, Cu++ transporting, alpha polypeptide , transcriptvariant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M24740  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38X106,027,595 - 106,027,655EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:99400 AgrOrtholog
Ensembl Genes ENSMUSG00000033792 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000055941 ENTREZGENE
  ENSMUST00000113557 ENTREZGENE
  ENSMUST00000113557.8 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.70.100 UniProtKB/Swiss-Prot
  3.40.1110.10 UniProtKB/Swiss-Prot
  3.40.50.1000 UniProtKB/Swiss-Prot
  Calcium-transporting ATPase, cytoplasmic transduction domain A UniProtKB/Swiss-Prot
InterPro ATPase_P-typ_cyto_dom_N UniProtKB/Swiss-Prot
  ATPase_P-typ_P_site UniProtKB/Swiss-Prot
  ATPase_P-typ_TM_dom_sf UniProtKB/Swiss-Prot
  ATPase_P-typ_transduc_dom_A_sf UniProtKB/Swiss-Prot
  HAD-like_sf UniProtKB/Swiss-Prot
  HAD_sf UniProtKB/Swiss-Prot
  Heavy-metal-associated_CS UniProtKB/Swiss-Prot
  HMA_Cu_ion-bd UniProtKB/Swiss-Prot
  HMA_dom UniProtKB/Swiss-Prot
  HMA_dom_sf UniProtKB/Swiss-Prot
  P-typ_ATPase_IB UniProtKB/Swiss-Prot
  P_typ_ATPase UniProtKB/Swiss-Prot
  P_typ_ATPase_HD_dom UniProtKB/Swiss-Prot
KEGG Report mmu:11977 UniProtKB/Swiss-Prot
MGD MGI:99400 ENTREZGENE
NCBI Gene 11977 ENTREZGENE
PANTHER P-TYPE CATION-TRANSPORTING ATPASE UniProtKB/Swiss-Prot
  P-TYPE CATION-TRANSPORTING ATPASE UniProtKB/Swiss-Prot
Pfam E1-E2_ATPase UniProtKB/Swiss-Prot
  HMA UniProtKB/Swiss-Prot
  Hydrolase UniProtKB/Swiss-Prot
PharmGKB ATP7A RGD
PhenoGen Atp7a PhenoGen
PRINTS CATATPASE UniProtKB/Swiss-Prot
  CUATPASEI UniProtKB/Swiss-Prot
PROSITE ATPASE_E1_E2 UniProtKB/Swiss-Prot
  HMA_1 UniProtKB/Swiss-Prot
  HMA_2 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF55008 UniProtKB/Swiss-Prot
  SSF56784 UniProtKB/Swiss-Prot
  SSF81653 UniProtKB/Swiss-Prot
  SSF81665 UniProtKB/Swiss-Prot
UniProt A0A1B4Z9K1_MOUSE UniProtKB/TrEMBL
  A2AG68 ENTREZGENE, UniProtKB/TrEMBL
  A2AG69 ENTREZGENE
  ATP7A_MOUSE UniProtKB/Swiss-Prot
  B9EJ97 ENTREZGENE, UniProtKB/TrEMBL
  O35101 ENTREZGENE
  P97422 ENTREZGENE
  Q3T9Y7_MOUSE UniProtKB/TrEMBL
  Q3TAY6_MOUSE UniProtKB/TrEMBL
  Q64430 ENTREZGENE
  Q64431 ENTREZGENE
UniProt Secondary A2AG69 UniProtKB/Swiss-Prot
  O35101 UniProtKB/Swiss-Prot
  P97422 UniProtKB/Swiss-Prot
  Q64431 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2024-08-06 Atp7a  ATPase, copper transporting, alpha polypeptide  Atp7a  ATPase, Cu++ transporting, alpha polypeptide  Symbol and/or name change 5135510 APPROVED