Akt2 (thymoma viral proto-oncogene 2) - Rat Genome Database

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Gene: Akt2 (thymoma viral proto-oncogene 2) Mus musculus
Analyze
Symbol: Akt2
Name: thymoma viral proto-oncogene 2
RGD ID: 10132
MGI Page MGI
Description: Enables protein serine/threonine kinase activity. Involved in negative regulation of PERK-mediated unfolded protein response and positive regulation of protein targeting to membrane. Acts upstream of or within several processes, including cellular response to high light intensity; insulin receptor signaling pathway; and peripheral nervous system myelin maintenance. Located in cell cortex and ruffle membrane. Is expressed in several structures, including central nervous system; genitourinary system; gut; hemolymphoid system gland; and integumental system. Used to study polycystic ovary syndrome and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in glucose metabolism disease (multiple); high grade glioma; and reproductive organ cancer (multiple). Orthologous to human AKT2 (AKT serine/threonine kinase 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 2410016A19Rik; AW554154; MGC14031; PK; PKB; PKB beta; PKBbe; PKBbeta; protein kinase Akt-2; protein kinase B beta; protein kinase B, beta; RAC-beta serine/threonine protein kinase; RAC-beta serine/threonine-protein kinase; RAC-PK-beta
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Akt2-ps  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39727,290,977 - 27,340,251 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl727,290,977 - 27,340,251 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38727,591,552 - 27,640,826 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl727,591,552 - 27,640,826 (+)Ensemblmm10GRCm38
MGSCv37728,376,579 - 28,424,472 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36727,314,618 - 27,348,214 (+)NCBIMGSCv36mm8
Celera722,173,505 - 22,221,607 (+)NCBICelera
Cytogenetic Map7A3NCBI
cM Map715.94NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(-)-gambogic acid  (ISO)
(1->4)-beta-D-glucan  (EXP)
(S)-nicotine  (EXP,ISO)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP,ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2-ethoxyethanol  (ISO)
2-methoxyethanol  (ISO)
2-nitrotoluene  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-nonylphenol  (ISO)
4-phenylbutyric acid  (ISO)
4-vinylcyclohexene dioxide  (EXP)
5-fluorouracil  (ISO)
acetamide  (ISO)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
acrylamide  (ISO)
afimoxifene  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
allethrin  (ISO)
alpha-pinene  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (EXP,ISO)
Benzo[k]fluoranthene  (ISO)
berberine  (EXP,ISO)
Bergenin  (EXP)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP)
bromochloroacetic acid  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (EXP,ISO)
butyric acid  (ISO)
C.I. Natural Red 20  (ISO)
C60 fullerene  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (EXP)
carmustine  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
clozapine  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cortisol  (ISO)
crocin-1  (EXP)
Cuprizon  (ISO)
curcumin  (EXP,ISO)
D-glucose  (EXP,ISO)
decabromodiphenyl ether  (ISO)
dexamethasone  (EXP,ISO)
Di-n-octyl phthalate  (EXP,ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibutyl phthalate  (EXP)
dichlorine  (ISO)
diclofenac  (ISO)
dideuterium oxide  (ISO)
dieldrin  (ISO)
diethyl phthalate  (EXP)
Diisodecyl phthalate  (EXP)
diisononyl phthalate  (EXP)
dimethoate  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
emodin  (EXP,ISO)
epoxiconazole  (EXP)
ethanol  (EXP,ISO)
everolimus  (ISO)
finasteride  (ISO)
flutamide  (ISO)
genistein  (EXP,ISO)
Ginsenoside Rg5  (EXP)
glucose  (EXP,ISO)
haloperidol  (ISO)
hesperidin  (ISO)
hexachlorobenzene  (ISO)
hydralazine  (ISO)
hydrogen cyanide  (EXP)
hydrogen peroxide  (ISO)
hydroquinone  (EXP)
insulin  (ISO)
inulin  (EXP)
isoprenaline  (ISO)
L-ascorbic acid  (ISO)
lead diacetate  (EXP,ISO)
lead(0)  (ISO)
losartan  (EXP)
maleic acid  (ISO)
MeIQ  (ISO)
MeIQx  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
metformin  (ISO)
methimazole  (EXP,ISO)
methoxychlor  (EXP,ISO)
methylglyoxal  (EXP)
methylseleninic acid  (ISO)
microcystin-LR  (ISO)
MK-2206  (ISO)
N,N-diethyl-m-toluamide  (ISO)
N-[3-(aminomethyl)benzyl]acetamidine  (EXP)
N-acetyl-L-cysteine  (ISO)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (EXP)
N-Vinyl-2-pyrrolidone  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nicotine  (EXP,ISO)
nitenpyram  (ISO)
nitrofen  (ISO)
obeticholic acid  (ISO)
oxaliplatin  (ISO)
ozone  (EXP,ISO)
p-menthan-3-ol  (ISO)
Pachymic acid  (EXP)
paclitaxel  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
PCB138  (ISO)
perfluorododecanoic acid  (ISO)
perfluoroheptanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluoroundecanoic acid  (ISO)
permethrin  (ISO)
Phellopterin  (ISO)
phenobarbital  (ISO)
PhIP  (ISO)
pirfenidone  (ISO)
pirinixic acid  (ISO)
propiconazole  (EXP)
quercetin  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
Shikonin  (ISO)
silicon dioxide  (ISO)
sinapic acid  (ISO)
sirolimus  (ISO)
sodium arsenite  (EXP,ISO)
sodium tungstate  (ISO)
streptozocin  (ISO)
sulindac  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
thymoquinone  (EXP)
titanium dioxide  (EXP)
topotecan  (ISO)
torcetrapib  (ISO)
triciribine  (ISO)
triphenyl phosphate  (ISO)
triphenylstannane  (ISO)
Triptolide  (ISO)
tunicamycin  (ISO)
valproic acid  (EXP,ISO)
vincristine  (ISO)
wortmannin  (ISO)
xanthohumol  (EXP,ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zingerone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of GTPase activity  (IGI)
apoptotic process  (IEA)
cellular response to high light intensity  (IMP)
cellular response to hormone stimulus  (ISO)
cellular response to insulin stimulus  (IEA,ISO)
glucose metabolic process  (IEA,IMP)
glycogen biosynthetic process  (IEA)
glycogen metabolic process  (IEA)
insulin receptor signaling pathway  (IBA,IDA,IEA,ISO)
intracellular signal transduction  (IBA)
negative regulation of apoptotic process  (IBA,ISO)
negative regulation of long-chain fatty acid import across plasma membrane  (IEA,ISO)
negative regulation of PERK-mediated unfolded protein response  (IDA,IEA)
negative regulation of RNA splicing  (ISO)
peripheral nervous system myelin maintenance  (IMP)
phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
positive regulation of adipose tissue development  (ISO)
positive regulation of blood vessel endothelial cell migration  (IBA)
positive regulation of cap-dependent translational initiation  (IEA,ISO,ISS)
positive regulation of cell migration  (IEA,ISO)
positive regulation of cell motility  (IEA,ISO)
positive regulation of D-glucose import  (IEA,IGI,ISO)
positive regulation of fatty acid beta-oxidation  (IEA,ISO)
positive regulation of gene expression  (ISO)
positive regulation of glucose metabolic process  (IEA,ISO)
positive regulation of glycogen biosynthetic process  (IEA,ISO)
positive regulation of nitric oxide biosynthetic process  (ISO)
positive regulation of positive chemotaxis  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of protein targeting to membrane  (IMP)
positive regulation of signal transduction  (ISO)
positive regulation of sodium ion transport  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
protein localization to plasma membrane  (IGI)
protein phosphorylation  (IDA,ISO)
protein stabilization  (IEA,ISO,ISS)
regulation of translation  (IEA)
response to hypoxia  (ISO)
response to insulin  (ISO)
response to muscle activity  (ISO)
response to nutrient levels  (ISO)
retinal rod cell apoptotic process  (IMP)

Cellular Component
cell cortex  (IMP)
cytoplasm  (IEA,ISO,ISS)
cytosol  (IEA,ISO)
early endosome  (IEA)
insulin-responsive compartment  (ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IEA,ISO)
plasma membrane  (IEA,IMP,ISO,TAS)
ruffle membrane  (IMP)
sarcoplasmic reticulum  (ISO)
vesicle  (ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal glucose homeostasis  (IAGP)
abnormal keratinocyte morphology  (IAGP)
abnormal lipid homeostasis  (IAGP)
abnormal liver morphology  (IAGP)
abnormal ovary morphology  (IAGP)
abnormal testis morphology  (IAGP)
arrested T cell differentiation  (IAGP)
decreased adipocyte glucose uptake  (IAGP)
decreased birth weight  (IAGP)
decreased body length  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased brain weight  (IAGP)
decreased brown adipose tissue mass  (IAGP)
decreased circulating cholesterol level  (IAGP)
decreased circulating glucose level  (IAGP)
decreased circulating insulin level  (IAGP)
decreased circulating leptin level  (IAGP)
decreased circulating testosterone level  (IAGP)
decreased corpora lutea number  (IAGP)
decreased double-positive T cell number  (IAGP)
decreased fetal weight  (IAGP)
decreased hair follicle number  (IAGP)
decreased insulin secretion  (IAGP)
decreased liver triglyceride level  (IAGP)
decreased liver weight  (IAGP)
decreased pancreatic beta cell number  (IAGP)
decreased percent body fat/body weight  (IAGP)
decreased skeletal muscle cell glucose uptake  (IAGP)
decreased susceptibility to diet-induced obesity  (IAGP)
decreased susceptibility to hepatic steatosis  (IAGP)
decreased testis weight  (IAGP)
decreased white adipose tissue amount  (IAGP)
decreased white adipose tissue mass  (IAGP)
delayed bone ossification  (IAGP)
enlarged pancreatic islets  (IAGP)
hyperglycemia  (IAGP)
impaired glucose tolerance  (IAGP)
increased circulating glucose level  (IAGP)
increased circulating insulin level  (IAGP)
increased circulating testosterone level  (IAGP)
increased double-negative T cell number  (IAGP)
increased mammary adenocarcinoma incidence  (IAGP)
increased pancreatic islet number  (IAGP)
increased T cell apoptosis  (IAGP)
increased theca cell number  (IAGP)
increased tumor latency  (IAGP)
insulin resistance  (IAGP)
muscle hypoplasia  (IAGP)
no abnormal phenotype detected  (IAGP)
ovary cyst  (IAGP)
perinatal lethality  (IAGP)
prenatal lethality, complete penetrance  (IAGP)
respiratory distress  (IAGP)
thin epidermis stratum spinosum  (IAGP)
thin skin  (IAGP)
thymus hypoplasia  (IAGP)
translucent skin  (IAGP)
underdeveloped hair follicles  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Defective signaling through Akt-2 and -3 but not Akt-1 in insulin-resistant human skeletal muscle: potential role in insulin resistance. Brozinick JT Jr, etal., Diabetes. 2003 Apr;52(4):935-41.
2. Genetic variations in a PTEN/AKT/mTOR axis and prostate cancer risk in a Chinese population. Chen J, etal., PLoS One. 2012;7(7):e40817. doi: 10.1371/journal.pone.0040817. Epub 2012 Jul 18.
3. Leptin deficiency and beta-cell dysfunction underlie type 2 diabetes in compound Akt knockout mice. Chen WS, etal., Mol Cell Biol. 2009 Jun;29(11):3151-62. Epub 2009 Mar 16.
4. PTEN-deficient tumors depend on AKT2 for maintenance and survival. Chin YR, etal., Cancer Discov. 2014 Aug;4(8):942-55. doi: 10.1158/2159-8290.CD-13-0873. Epub 2014 May 16.
5. Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta). Cho H, etal., Science 2001 Jun 1;292(5522):1728-31.
6. Continuous fat oxidation in acetyl-CoA carboxylase 2 knockout mice increases total energy expenditure, reduces fat mass, and improves insulin sensitivity. Choi CS, etal., Proc Natl Acad Sci U S A. 2007 Oct 16;104(42):16480-5. Epub 2007 Oct 8.
7. Isoform-specific defects of insulin stimulation of Akt/protein kinase B (PKB) in skeletal muscle cells from type 2 diabetic patients. Cozzone D, etal., Diabetologia. 2008 Mar;51(3):512-21. Epub 2008 Jan 18.
8. A truncation mutation in TBC1D4 in a family with acanthosis nigricans and postprandial hyperinsulinemia. Dash S, etal., Proc Natl Acad Sci U S A. 2009 Jun 9;106(23):9350-5. doi: 10.1073/pnas.0900909106. Epub 2009 May 22.
9. Defective neurogenesis in citron kinase knockout mice by altered cytokinesis and massive apoptosis. Di Cunto F, etal., Neuron 2000 Oct;28(1):115-27.
10. Akt1 and akt2 play distinct roles in the initiation and metastatic phases of mammary tumor progression. Dillon RL, etal., Cancer Res. 2009 Jun 15;69(12):5057-64. Epub 2009 Jun 2.
11. The role of Akt/protein kinase B subtypes in retinal ischemic preconditioning. Dreixler JC, etal., Exp Eye Res. 2009 Mar;88(3):512-21. Epub 2008 Dec 3.
12. The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism. Engelman JA, etal., Nat Rev Genet. 2006 Aug;7(8):606-19.
13. Gene expression profiling and functional proteomic analysis reveal perturbed kinase-mediated signaling in genetic stroke susceptibility. Fornage M, etal., Physiol Genomics. 2003 Sep 29;15(1):75-83.
14. PI3K/Akt: getting it right matters. Franke TF Oncogene. 2008 Oct 27;27(50):6473-88.
15. Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKB beta. Garofalo RS, etal., J Clin Invest. 2003 Jul;112(2):197-208. Epub 2003 Jul 3.
16. A family with severe insulin resistance and diabetes due to a mutation in AKT2. George S, etal., Science. 2004 May 28;304(5675):1325-8.
17. Akt mediates insulin induction of glucose uptake and up-regulation of GLUT4 gene expression in brown adipocytes. Hernandez R, etal., FEBS Lett. 2001 Apr 13;494(3):225-31.
18. Phosphoinositide 3-kinases as a common platform for multi-hormone signaling. Hirsch E, etal., J Endocrinol. 2007 Aug;194(2):243-56.
19. An activating mutation of AKT2 and human hypoglycemia. Hussain K, etal., Science. 2011 Oct 28;334(6055):474. doi: 10.1126/science.1210878. Epub 2011 Oct 6.
20. Potentiation of insulin signaling in tissues of Zucker obese rats after acute and long-term treatment with PPARgamma agonists. Jiang G, etal., Diabetes. 2002 Aug;51(8):2412-9.
21. The phosphatidylinositol 3-kinase/Akt signaling pathway modulates the endocrine differentiation of trophoblast cells. Kamei T, etal., Mol Endocrinol 2002 Jul;16(7):1469-81.
22. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
23. Inhibition of LINE-1 expression in the heart decreases ischemic damage by activation of Akt/PKB signaling. Lucchinetti E, etal., Physiol Genomics. 2006 Apr 13;25(2):314-24. Epub 2006 Jan 17.
24. Akt1 ablation inhibits, whereas Akt2 ablation accelerates, the development of mammary adenocarcinomas in mouse mammary tumor virus (MMTV)-ErbB2/neu and MMTV-polyoma middle T transgenic mice. Maroulakou IG, etal., Cancer Res. 2007 Jan 1;67(1):167-77.
25. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
26. MGDs mouse GO annotations MGD data from the GO Consortium
27. MGD IEA MGD IEA
28. Akt2 and Akt3 play a pivotal role in malignant gliomas. Mure H, etal., Neuro Oncol. 2010 Mar;12(3):221-32. doi: 10.1093/neuonc/nop026. Epub 2009 Dec 21.
29. Sequence mutations and amplification of PIK3CA and AKT2 genes in purified ovarian serous neoplasms. Nakayama K, etal., Cancer Biol Ther. 2006 Jul;5(7):779-85. Epub 2006 Jul 26.
30. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
31. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
32. Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2. Peng XD, etal., Genes Dev 2003 Jun 1;17(11):1352-65.
33. Satellite cell proliferation is reduced in muscles of obese Zucker rats but restored with loading. Peterson JM, etal., Am J Physiol Cell Physiol. 2008 Aug;295(2):C521-8. Epub 2008 May 28.
34. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
35. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
36. Mouse MP Annotation Import Pipeline RGD automated import pipeline
37. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
38. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
39. AKT proto-oncogene overexpression is an early event during sporadic colon carcinogenesis. Roy HK, etal., Carcinogenesis. 2002 Jan;23(1):201-5.
40. Knockdown of Akt isoforms by RNA silencing suppresses the growth of human prostate cancer cells in vitro and in vivo. Sasaki T, etal., Biochem Biophys Res Commun. 2010 Aug 13;399(1):79-83. doi: 10.1016/j.bbrc.2010.07.045. Epub 2010 Jul 16.
41. Janus Kinase 2 (JAK2) Dissociates Hepatosteatosis from Hepatocellular Carcinoma in Mice. Shi SY, etal., J Biol Chem. 2017 Mar 3;292(9):3789-3799. doi: 10.1074/jbc.M116.752519. Epub 2017 Jan 18.
42. Analysis of genetic variation in Akt2/PKB-beta in severe insulin resistance, lipodystrophy, type 2 diabetes, and related metabolic phenotypes. Tan K, etal., Diabetes. 2007 Mar;56(3):714-9.
43. Crosstalk between PTEN/Akt2 and TGFbeta signaling involving EGF receptor down-regulation during the tumor promotion process from the early stage in a rat two-stage hepatocarcinogenesis model. Taniai E, etal., Cancer Sci. 2009 May;100(5):813-20. Epub 2009 Mar 20.
44. Combined thiazolidinedione-metformin treatment synergistically improves insulin signalling to insulin receptor substrate-1-dependent phosphatidylinositol 3-kinase, atypical protein kinase C and protein kinase B/Akt in human diabetic muscle. Temofonte N, etal., Diabetologia. 2009 Jan;52(1):60-4. Epub 2008 Oct 30.
45. Roles of genetic variants in the PI3K and RAS/RAF pathways in susceptibility to endometrial cancer and clinical outcomes. Wang LE, etal., J Cancer Res Clin Oncol. 2012 Mar;138(3):377-85. doi: 10.1007/s00432-011-1103-0. Epub 2011 Dec 7.
46. GLUT4 translocation: the last 200 nanometers. Watson RT and Pessin JE, Cell Signal. 2007 Nov;19(11):2209-17. Epub 2007 Jun 21.
47. Pancreatic cancer: molecular pathogenesis and new therapeutic targets. Wong HH and Lemoine NR, Nat Rev Gastroenterol Hepatol. 2009 Jul;6(7):412-22. Epub 2009 Jun 9.
48. The effect Akt2 deletion on tumor development in Pten(+/-) mice. Xu PZ, etal., Oncogene. 2012 Jan 26;31(4):518-26. doi: 10.1038/onc.2011.243. Epub 2011 Jul 11.
49. Insulin action on glucose transporters through molecular switches, tracks and tethers. Zaid H, etal., Biochem J. 2008 Jul 15;413(2):201-15.
50. Reduction of Akt2 inhibits migration and invasion of glioma cells. Zhang B, etal., Int J Cancer. 2009 Aug 1;125(3):585-95.
Additional References at PubMed
PMID:219800   PMID:3037531   PMID:7566964   PMID:8889548   PMID:8976376   PMID:9620559   PMID:10349636   PMID:10579998   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11861503  
PMID:12107176   PMID:12477932   PMID:12520002   PMID:12773577   PMID:12783884   PMID:12791994   PMID:12808085   PMID:12944902   PMID:14502571   PMID:14504284   PMID:14610273   PMID:14744864  
PMID:14749824   PMID:14755341   PMID:15050688   PMID:15082758   PMID:15220355   PMID:15489334   PMID:15538381   PMID:15545269   PMID:15546921   PMID:15632167   PMID:15684423   PMID:15695173  
PMID:15713641   PMID:15753085   PMID:15764603   PMID:15782199   PMID:15843895   PMID:15855319   PMID:16005454   PMID:16075056   PMID:16141072   PMID:16141073   PMID:16166629   PMID:16260781  
PMID:16287854   PMID:16510873   PMID:16602821   PMID:16792529   PMID:16803855   PMID:16804077   PMID:16923802   PMID:16923958   PMID:16950770   PMID:16962829   PMID:16982699   PMID:17012749  
PMID:17019809   PMID:17021050   PMID:17045205   PMID:17056562   PMID:17141631   PMID:17202487   PMID:17301033   PMID:17439945   PMID:17442925   PMID:17515613   PMID:17554339   PMID:17565718  
PMID:17609365   PMID:17634444   PMID:17912369   PMID:17914025   PMID:17964260   PMID:17967808   PMID:17982014   PMID:18042802   PMID:18160256   PMID:18218855   PMID:18256806   PMID:18287559  
PMID:18316591   PMID:18330587   PMID:18339807   PMID:18396141   PMID:18449193   PMID:18561256   PMID:18562309   PMID:18718528   PMID:18757368   PMID:18799693   PMID:18978355   PMID:19066218  
PMID:19074768   PMID:19116344   PMID:19139280   PMID:19142853   PMID:19166849   PMID:19197940   PMID:19372382   PMID:19389359   PMID:19433625   PMID:19622728   PMID:19805051   PMID:19825827  
PMID:19850877   PMID:19883618   PMID:19923418   PMID:19933838   PMID:19995912   PMID:20022950   PMID:20040596   PMID:20042722   PMID:20079728   PMID:20111592   PMID:20164156   PMID:20194497  
PMID:20223817   PMID:20236253   PMID:20332370   PMID:20348245   PMID:20354168   PMID:20448149   PMID:20511715   PMID:20576936   PMID:20665729   PMID:20668162   PMID:20687898   PMID:20701589  
PMID:20705244   PMID:20724596   PMID:20728450   PMID:20799038   PMID:20816796   PMID:20837017   PMID:20849614   PMID:20856813   PMID:21135503   PMID:21148297   PMID:21242979   PMID:21267068  
PMID:21295499   PMID:21367821   PMID:21551011   PMID:21555366   PMID:21555401   PMID:21576358   PMID:21624358   PMID:21625009   PMID:21633171   PMID:21670275   PMID:21677750   PMID:21737686  
PMID:21823353   PMID:21873635   PMID:21890689   PMID:21907143   PMID:21946561   PMID:21953010   PMID:21954288   PMID:21960994   PMID:21980074   PMID:21982711   PMID:22003059   PMID:22117619  
PMID:22228739   PMID:22275470   PMID:22312125   PMID:22334075   PMID:22344295   PMID:22567161   PMID:22647600   PMID:22666383   PMID:22678916   PMID:22814751   PMID:22851690   PMID:22927331  
PMID:23028142   PMID:23076793   PMID:23100026   PMID:23166294   PMID:23250987   PMID:23275438   PMID:23376468   PMID:23673657   PMID:23749633   PMID:23823123   PMID:23823480   PMID:23872024  
PMID:23919516   PMID:23968884   PMID:24056770   PMID:24123662   PMID:24126057   PMID:24126911   PMID:24156551   PMID:24169049   PMID:24194853   PMID:24220638   PMID:24277697   PMID:24296248  
PMID:24438685   PMID:24462114   PMID:24472646   PMID:24496246   PMID:24577082   PMID:24622975   PMID:24642468   PMID:24663486   PMID:24687281   PMID:24722238   PMID:24805195   PMID:24819347  
PMID:24845341   PMID:25001283   PMID:25025572   PMID:25037569   PMID:25136137   PMID:25148525   PMID:25205222   PMID:25240046   PMID:25253241   PMID:25285168   PMID:25392271   PMID:25416384  
PMID:25502566   PMID:25550458   PMID:25575350   PMID:25662011   PMID:25688191   PMID:25730471   PMID:25740694   PMID:25811375   PMID:25883023   PMID:25969542   PMID:26100075   PMID:26227811  
PMID:26265698   PMID:26286748   PMID:26296318   PMID:26340929   PMID:26411367   PMID:26453378   PMID:26473496   PMID:26496610   PMID:26654940   PMID:26668316   PMID:26716908   PMID:26745185  
PMID:26865945   PMID:26971877   PMID:26996309   PMID:27098694   PMID:27163697   PMID:27238637   PMID:27307790   PMID:27317762   PMID:27363949   PMID:27408773   PMID:27545875   PMID:27576939  
PMID:27699769   PMID:27746098   PMID:27938661   PMID:28115273   PMID:28272306   PMID:28394260   PMID:28455433   PMID:28557977   PMID:28671671   PMID:28681509   PMID:28849233   PMID:28965945  
PMID:29025710   PMID:29035283   PMID:29055016   PMID:29079702   PMID:29120957   PMID:29153407   PMID:29170369   PMID:29173281   PMID:29202451   PMID:29301787   PMID:29378301   PMID:29458977  
PMID:29666415   PMID:29678907   PMID:29933193   PMID:30337485   PMID:30463689   PMID:30567482   PMID:30574832   PMID:30692211   PMID:30718296   PMID:30735546   PMID:30833219   PMID:30973865  
PMID:31109453   PMID:31442424   PMID:31496625   PMID:31548312   PMID:31552693   PMID:31683681   PMID:31755338   PMID:31767615   PMID:31882361   PMID:31996678   PMID:32025205   PMID:32078465  
PMID:32096546   PMID:32252758   PMID:32325033   PMID:32464093   PMID:32512189   PMID:32796067   PMID:32880392   PMID:32931746   PMID:33110146   PMID:33199895   PMID:33325370   PMID:33328589  
PMID:33450278   PMID:33514739   PMID:34010646   PMID:34038004   PMID:34053181   PMID:34296180   PMID:34321999   PMID:34363211   PMID:34385359   PMID:34751006   PMID:34900533   PMID:35163412  
PMID:35294873   PMID:35303074   PMID:35663017   PMID:35781329   PMID:35878016   PMID:36130126   PMID:36198696   PMID:36229454   PMID:36417873   PMID:36719624   PMID:37053038   PMID:37184210  
PMID:37443129   PMID:37852976   PMID:38244769   PMID:38355793   PMID:38643275   PMID:38825497   PMID:38880808   PMID:39034314   PMID:39172791   PMID:40075076   PMID:40080583   PMID:40208790  
PMID:40663491  


Genomics

Comparative Map Data
Akt2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39727,290,977 - 27,340,251 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl727,290,977 - 27,340,251 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38727,591,552 - 27,640,826 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl727,591,552 - 27,640,826 (+)Ensemblmm10GRCm38
MGSCv37728,376,579 - 28,424,472 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36727,314,618 - 27,348,214 (+)NCBIMGSCv36mm8
Celera722,173,505 - 22,221,607 (+)NCBICelera
Cytogenetic Map7A3NCBI
cM Map715.94NCBI
AKT2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381940,230,317 - 40,285,345 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1940,230,317 - 40,285,536 (-)Ensemblhg38GRCh38
GRCh371940,736,224 - 40,791,252 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361945,428,064 - 45,483,105 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341945,431,555 - 45,483,034NCBI
Celera1937,535,771 - 37,590,707 (-)NCBICelera
Cytogenetic Map19q13.2NCBI
HuRef1937,171,156 - 37,226,119 (-)NCBIHuRef
CHM1_11940,735,896 - 40,790,984 (-)NCBICHM1_1
T2T-CHM13v2.01943,050,812 - 43,105,845 (-)NCBIT2T-CHM13v2.0
Akt2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8192,004,705 - 92,061,420 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl192,014,859 - 92,061,420 (+)EnsemblGRCr8
mRatBN7.2182,877,228 - 82,933,828 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl182,883,547 - 82,933,817 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx188,296,913 - 88,335,355 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0196,784,353 - 96,822,706 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0190,052,776 - 90,091,219 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0184,400,939 - 84,451,223 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl184,411,726 - 84,450,162 (+)Ensemblrn6Rnor6.0
Rnor_5.0185,617,612 - 85,667,423 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4182,686,233 - 82,726,544 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera177,307,278 - 77,345,638 (+)NCBICelera
RGSC_v3.1182,764,343 - 82,804,655 (+)NCBI
Cytogenetic Map1q21NCBI
Akt2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955578967,593 - 1,004,438 (+)Ensembl
ChiLan1.0NW_004955578950,258 - 1,004,438 (+)NCBIChiLan1.0ChiLan1.0
AKT2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22046,489,586 - 46,553,446 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11948,360,226 - 48,417,200 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01937,275,799 - 37,331,971 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11945,791,043 - 45,846,359 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1945,791,800 - 45,840,271 (-)EnsemblpanPan2panpan1.1
AKT2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11113,359,038 - 113,407,119 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1113,359,575 - 113,407,131 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1112,790,741 - 112,808,659 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01113,957,825 - 114,008,296 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1113,958,298 - 114,008,293 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11113,546,597 - 113,564,514 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01113,179,139 - 113,197,049 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01114,172,976 - 114,190,895 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Akt2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934914,224,502 - 14,265,970 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366612,652,566 - 2,694,086 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366612,652,568 - 2,694,039 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AKT2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl648,555,795 - 48,587,919 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1648,555,785 - 48,620,472 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2644,331,695 - 44,393,119 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AKT2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1634,688,585 - 34,740,458 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl634,690,462 - 34,720,781 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607312,782,360 - 12,833,428 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Akt2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624925273,881 - 326,984 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624925262,590 - 322,440 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Akt2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12168,301,436 - 168,351,906 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Akt2
2459 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:5400
Count of miRNA genes:853
Interacting mature miRNAs:1173
Transcripts:ENSMUST00000051356, ENSMUST00000085917, ENSMUST00000108342, ENSMUST00000108343, ENSMUST00000108344, ENSMUST00000128540, ENSMUST00000136962, ENSMUST00000136981, ENSMUST00000138459, ENSMUST00000142365, ENSMUST00000143347, ENSMUST00000143499, ENSMUST00000147263, ENSMUST00000167435
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300722Sle3_msystemic lupus erythmatosus susceptibility 3 (mouse)Not determined7351172887142720Mouse
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76502999133501729Mouse
4141566Femwf8_mfemur work to failure 8 (mouse)Not determined1303248547032621Mouse
1301041Prnr2_mprion resistance 2 (mouse)Not determined71872879439674033Mouse
12904742Litsq2_mlitter size QTL 2 (mouse)72267388756674033Mouse
1301969Lbw5_mlupus NZB x NZW 5 (mouse)Not determined72684761560851775Mouse
1301622Eae12_msusceptibility to experimental allergic encephalomyelitis 12 (mouse)Not determined71928001553280104Mouse
11354952Pdcc1_mplasmacytoid dentritic cell compartment 1 (mouse)72306653157066531Mouse
38501068Tip1_mtuberculosis immunophenotype 1, spleen CFU (mouse)7360299972549748Mouse
25314314Sccor1_msynaptonemal complex length to mean MLH1 count ratio 1 (mouse)71333392547349748Mouse
7394747asp3_maudiogenic seizure prone 3 (mouse)Not determined72730579836842367Mouse
10449139Eosn1_meosinophil differential 1 (mouse)71248087746480877Mouse
1301052Bhr6_mbronchial hyperresponsiveness 6 (mouse)Not determined71984225053842367Mouse
11522751Cocia17_mcocaine-induced activity, QTL 17 (mouse)71313520447135204Mouse
12792978Fbmd3_mfemoral bone mineral density 3, females only (mouse)77050288142367832Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719147398141919804Mouse
1301572Sluc30_msusceptibility to lung cancer 30 (mouse)Not determined7243169636431844Mouse
1357699Nhdlq6_mnon-HDL QTL 6 (mouse)Not determined7998886743988984Mouse
10449158Eosn3_meosinophil differential 3 (mouse)71248087746480877Mouse
10412199Sst2_msusceptibility to tuberculosis 2 (mouse)Not determined718728794119485380Mouse
1558893Spir1_mStreptococcus pneumoniae infection resistance 1 (mouse)Not determined71030579844305936Mouse
1301709Bdt4_mbone density traits 4 (mouse)Not determined72288857256888716Mouse
1559016Drsi_mDCC-related Spp1 induction (mouse)Not determined71663729349159331Mouse

Markers in Region
AW554154  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38727,640,309 - 27,640,404UniSTSGRCm38
MGSCv37728,425,328 - 28,425,423UniSTSGRCm37
Celera722,222,463 - 22,222,558UniSTS
Cytogenetic Map7B1UniSTS
cM Map76.5UniSTS
Whitehead/MRC_RH7386.84UniSTS
RH94820  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381116,516,143 - 16,516,256UniSTSGRCm38
GRCm38727,638,283 - 27,638,395UniSTSGRCm38
MGSCv37728,423,302 - 28,423,414UniSTSGRCm37
MGSCv371116,416,146 - 16,416,259UniSTSGRCm37
Celera1116,896,901 - 16,897,014UniSTS
Celera722,220,456 - 22,220,568UniSTS
Cytogenetic Map7B1UniSTS
Cytogenetic Map11A2UniSTS
cM Map76.5UniSTS
cM Map119.0UniSTS
D7Mit77  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38727,606,373 - 27,606,511UniSTSGRCm38
MGSCv37728,391,392 - 28,391,530UniSTSGRCm37
Celera722,188,317 - 22,188,455UniSTS
Cytogenetic Map7B1UniSTS
cM Map79.4UniSTS
Whitehead Genetic76.6UniSTS
Whitehead/MRC_RH7385.91UniSTS
Akt2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381116,516,091 - 16,517,142UniSTSGRCm38
GRCm38727,638,231 - 27,639,280UniSTSGRCm38
MGSCv37728,423,250 - 28,424,299UniSTSGRCm37
MGSCv371116,416,094 - 16,417,145UniSTSGRCm37
Celera722,220,404 - 22,221,434UniSTS
Celera1116,896,849 - 16,897,900UniSTS
Cytogenetic Map7B1UniSTS
Cytogenetic Map11A2UniSTS
cM Map76.5UniSTS
SGC30851  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381116,515,421 - 16,515,568UniSTSGRCm38
GRCm38727,636,093 - 27,636,336UniSTSGRCm38
MGSCv37728,421,112 - 28,421,355UniSTSGRCm37
MGSCv371116,415,424 - 16,415,571UniSTSGRCm37
Celera1116,896,196 - 16,896,343UniSTS
Celera722,218,266 - 22,218,509UniSTS
Cytogenetic Map7B1UniSTS
Cytogenetic Map11A2UniSTS
cM Map76.5UniSTS
cM Map119.0UniSTS
Akt2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381116,514,749 - 16,515,044UniSTSGRCm38
Celera1116,895,524 - 16,895,819UniSTS
Cytogenetic Map7B1UniSTS
Cytogenetic Map11A2UniSTS
Akt2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7B1UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001110208 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001331108 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001331109 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_007434 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006539481 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006539482 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006539483 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030241997 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030241998 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030241999 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030242000 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC074312 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK010511 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK028871 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK083753 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK144217 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK158792 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK163678 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK182878 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK185382 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK188476 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK191996 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK192065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK194817 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK197083 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK197364 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK201443 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK212175 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK219231 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB862964 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC026151 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC028759 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC040377 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM899551 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466593 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ152468 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ159088 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ311436 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U22445 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000051356   ⟹   ENSMUSP00000052103
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl727,305,283 - 27,338,878 (+)Ensembl
GRCm38.p6 Ensembl727,605,858 - 27,639,453 (+)Ensembl
Ensembl Acc Id: ENSMUST00000085917   ⟹   ENSMUSP00000083081
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl727,308,087 - 27,337,595 (+)Ensembl
GRCm38.p6 Ensembl727,608,662 - 27,638,170 (+)Ensembl
Ensembl Acc Id: ENSMUST00000108342   ⟹   ENSMUSP00000103979
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl727,291,883 - 27,332,691 (+)Ensembl
GRCm38.p6 Ensembl727,592,458 - 27,633,266 (+)Ensembl
Ensembl Acc Id: ENSMUST00000108343   ⟹   ENSMUSP00000103980
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl727,305,242 - 27,338,873 (+)Ensembl
GRCm38.p6 Ensembl727,605,817 - 27,639,448 (+)Ensembl
Ensembl Acc Id: ENSMUST00000108344   ⟹   ENSMUSP00000103981
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl727,290,977 - 27,340,251 (+)Ensembl
GRCm38.p6 Ensembl727,591,552 - 27,640,826 (+)Ensembl
Ensembl Acc Id: ENSMUST00000128540   ⟹   ENSMUSP00000122716
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl727,291,793 - 27,328,270 (+)Ensembl
GRCm38.p6 Ensembl727,592,368 - 27,628,845 (+)Ensembl
Ensembl Acc Id: ENSMUST00000136962   ⟹   ENSMUSP00000117682
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl727,307,173 - 27,332,671 (+)Ensembl
GRCm38.p6 Ensembl727,607,748 - 27,633,246 (+)Ensembl
Ensembl Acc Id: ENSMUST00000136981
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl727,335,478 - 27,336,868 (+)Ensembl
GRCm38.p6 Ensembl727,636,053 - 27,637,443 (+)Ensembl
Ensembl Acc Id: ENSMUST00000138459   ⟹   ENSMUSP00000123204
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl727,296,255 - 27,317,658 (+)Ensembl
GRCm38.p6 Ensembl727,596,830 - 27,618,233 (+)Ensembl
Ensembl Acc Id: ENSMUST00000142365   ⟹   ENSMUSP00000120978
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl727,307,429 - 27,317,711 (+)Ensembl
GRCm38.p6 Ensembl727,608,004 - 27,618,286 (+)Ensembl
Ensembl Acc Id: ENSMUST00000143347
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl727,327,950 - 27,334,236 (+)Ensembl
GRCm38.p6 Ensembl727,628,525 - 27,634,811 (+)Ensembl
Ensembl Acc Id: ENSMUST00000143499   ⟹   ENSMUSP00000117119
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl727,305,222 - 27,328,294 (+)Ensembl
GRCm38.p6 Ensembl727,605,797 - 27,628,869 (+)Ensembl
Ensembl Acc Id: ENSMUST00000147263
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl727,292,971 - 27,315,771 (+)Ensembl
GRCm38.p6 Ensembl727,593,546 - 27,616,346 (+)Ensembl
Ensembl Acc Id: ENSMUST00000167435   ⟹   ENSMUSP00000132141
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl727,291,171 - 27,338,875 (+)Ensembl
GRCm38.p6 Ensembl727,591,746 - 27,639,450 (+)Ensembl
RefSeq Acc Id: NM_001110208   ⟹   NP_001103678
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39727,290,977 - 27,340,251 (+)NCBI
GRCm38727,591,552 - 27,640,826 (+)NCBI
MGSCv37728,376,579 - 28,424,472 (+)RGD
Celera722,173,505 - 22,221,607 (+)RGD
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001331108   ⟹   NP_001318037
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39727,296,255 - 27,340,251 (+)NCBI
GRCm38727,596,830 - 27,640,826 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001331109   ⟹   NP_001318038
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39727,306,761 - 27,340,251 (+)NCBI
GRCm38727,607,336 - 27,640,826 (+)NCBI
Sequence:
RefSeq Acc Id: NM_007434   ⟹   NP_031460
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39727,305,222 - 27,340,251 (+)NCBI
GRCm38727,605,797 - 27,640,826 (+)NCBI
MGSCv37728,376,579 - 28,424,472 (+)RGD
Celera722,173,505 - 22,221,607 (+)RGD
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006539481   ⟹   XP_006539544
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39727,306,927 - 27,338,878 (+)NCBI
GRCm38727,607,480 - 27,639,453 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006539482   ⟹   XP_006539545
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39727,290,982 - 27,338,878 (+)NCBI
GRCm38727,591,702 - 27,639,453 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006539483   ⟹   XP_006539546
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39727,304,501 - 27,338,878 (+)NCBI
GRCm38727,605,151 - 27,639,453 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030241997   ⟹   XP_030097857
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39727,291,591 - 27,338,878 (+)NCBI
GRCm38727,592,151 - 27,639,453 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030241998   ⟹   XP_030097858
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39727,291,571 - 27,338,878 (+)NCBI
GRCm38727,592,146 - 27,639,453 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030241999   ⟹   XP_030097859
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39727,306,668 - 27,338,878 (+)NCBI
GRCm38727,607,243 - 27,639,453 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030242000   ⟹   XP_030097860
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39727,307,385 - 27,338,878 (+)NCBI
GRCm38727,607,948 - 27,639,453 (+)NCBI
Sequence:
RefSeq Acc Id: NP_031460   ⟸   NM_007434
- UniProtKB: Q60823 (UniProtKB/Swiss-Prot),   Q3TY95 (UniProtKB/TrEMBL),   F8WHG5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001103678   ⟸   NM_001110208
- UniProtKB: Q60823 (UniProtKB/Swiss-Prot),   Q3TY95 (UniProtKB/TrEMBL),   F8WHG5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006539545   ⟸   XM_006539482
- Peptide Label: isoform X2
- UniProtKB: F8WHG5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006539546   ⟸   XM_006539483
- Peptide Label: isoform X2
- UniProtKB: F8WHG5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006539544   ⟸   XM_006539481
- Peptide Label: isoform X1
- UniProtKB: Q60823 (UniProtKB/Swiss-Prot),   Q3TY95 (UniProtKB/TrEMBL),   F8WHG5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_030097858   ⟸   XM_030241998
- Peptide Label: isoform X1
- UniProtKB: Q60823 (UniProtKB/Swiss-Prot),   Q3TY95 (UniProtKB/TrEMBL),   F8WHG5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_030097857   ⟸   XM_030241997
- Peptide Label: isoform X1
- UniProtKB: Q60823 (UniProtKB/Swiss-Prot),   Q3TY95 (UniProtKB/TrEMBL),   F8WHG5 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001318037   ⟸   NM_001331108
- UniProtKB: Q60823 (UniProtKB/Swiss-Prot),   Q3TY95 (UniProtKB/TrEMBL),   F8WHG5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_030097859   ⟸   XM_030241999
- Peptide Label: isoform X1
- UniProtKB: Q60823 (UniProtKB/Swiss-Prot),   Q3TY95 (UniProtKB/TrEMBL),   F8WHG5 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001318038   ⟸   NM_001331109
- UniProtKB: Q60823 (UniProtKB/Swiss-Prot),   Q3TY95 (UniProtKB/TrEMBL),   F8WHG5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_030097860   ⟸   XM_030242000
- Peptide Label: isoform X1
- UniProtKB: Q60823 (UniProtKB/Swiss-Prot),   Q3TY95 (UniProtKB/TrEMBL),   F8WHG5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSMUSP00000083081   ⟸   ENSMUST00000085917
Ensembl Acc Id: ENSMUSP00000123204   ⟸   ENSMUST00000138459
Ensembl Acc Id: ENSMUSP00000052103   ⟸   ENSMUST00000051356
Ensembl Acc Id: ENSMUSP00000117119   ⟸   ENSMUST00000143499
Ensembl Acc Id: ENSMUSP00000103979   ⟸   ENSMUST00000108342
Ensembl Acc Id: ENSMUSP00000103981   ⟸   ENSMUST00000108344
Ensembl Acc Id: ENSMUSP00000103980   ⟸   ENSMUST00000108343
Ensembl Acc Id: ENSMUSP00000132141   ⟸   ENSMUST00000167435
Ensembl Acc Id: ENSMUSP00000122716   ⟸   ENSMUST00000128540
Ensembl Acc Id: ENSMUSP00000120978   ⟸   ENSMUST00000142365
Ensembl Acc Id: ENSMUSP00000117682   ⟸   ENSMUST00000136962
Protein Domains
AGC-kinase C-terminal   PH   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q60823-F1-model_v2 AlphaFold Q60823 1-481 view protein structure

Promoters
RGD ID:6892390
Promoter ID:EPDNEW_M9646
Type:initiation region
Name:Akt2_3
Description:Mus musculus thymoma viral proto-oncogene 2 , transcript variant4, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M9647  EPDNEW_M9648  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38727,591,643 - 27,591,703EPDNEW
RGD ID:6892392
Promoter ID:EPDNEW_M9647
Type:initiation region
Name:Akt2_2
Description:Mus musculus thymoma viral proto-oncogene 2 , transcript variant4, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M9646  EPDNEW_M9648  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38727,591,746 - 27,591,806EPDNEW
RGD ID:6892394
Promoter ID:EPDNEW_M9648
Type:initiation region
Name:Akt2_1
Description:Mus musculus thymoma viral proto-oncogene 2 , transcript variant4, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M9646  EPDNEW_M9647  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38727,605,854 - 27,605,914EPDNEW
RGD ID:6840573
Promoter ID:MM_KWN:49571
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   BoneMarrow_2Hour,   Brain,   Kidney,   MEF_B4
Transcripts:OTTMUST00000039869
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36728,381,821 - 28,382,321 (+)MPROMDB
RGD ID:6840575
Promoter ID:MM_KWN:49572
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day6,   Brain,   Kidney,   Liver,   Lung
Transcripts:ENSMUST00000051356,   ENSMUST00000108343,   OTTMUST00000039871
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36728,390,561 - 28,391,061 (+)MPROMDB
RGD ID:6840578
Promoter ID:MM_KWN:49573
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day4,   3T3L1_Day6,   Brain,   Kidney,   Liver,   Lung
Transcripts:OTTMUST00000039873,   OTTMUST00000039874,   UC009FWT.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36728,391,946 - 28,392,847 (+)MPROMDB
RGD ID:6840577
Promoter ID:MM_KWN:49575
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   Brain,   Kidney,   Liver
Transcripts:OTTMUST00000039875
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36728,412,871 - 28,413,371 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:104874 AgrOrtholog
Ensembl Genes ENSMUSG00000004056 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000051356 ENTREZGENE
  ENSMUST00000051356.12 UniProtKB/Swiss-Prot
  ENSMUST00000085917 ENTREZGENE
  ENSMUST00000108343 ENTREZGENE
  ENSMUST00000108343.8 UniProtKB/Swiss-Prot
  ENSMUST00000108344 ENTREZGENE
  ENSMUST00000108344.9 UniProtKB/Swiss-Prot
Gene3D-CATH 2.30.29.30 UniProtKB/Swiss-Prot
  Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
InterPro AGC-kinase_C UniProtKB/Swiss-Prot
  Akt2 UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  PH-like_dom_sf UniProtKB/Swiss-Prot
  PH_domain UniProtKB/Swiss-Prot
  PH_PKB UniProtKB/Swiss-Prot
  Pkinase_C UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
KEGG Report mmu:11652 UniProtKB/Swiss-Prot
MGD MGI:104874 ENTREZGENE
NCBI Gene 11652 ENTREZGENE
PANTHER RIBOSOMAL PROTEIN S6 KINASE UniProtKB/Swiss-Prot
Pfam PF00169 UniProtKB/Swiss-Prot
  Pkinase UniProtKB/Swiss-Prot
  Pkinase_C UniProtKB/Swiss-Prot
PharmGKB AKT2 RGD
PhenoGen Akt2 PhenoGen
PROSITE AGC_KINASE_CTER UniProtKB/Swiss-Prot
  PH_DOMAIN UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
SMART S_TK_X UniProtKB/Swiss-Prot
  S_TKc UniProtKB/Swiss-Prot
  SM00233 UniProtKB/Swiss-Prot
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot
  SSF56112 UniProtKB/Swiss-Prot
UniProt AKT2_MOUSE UniProtKB/Swiss-Prot
  D3YXM7_MOUSE UniProtKB/TrEMBL
  D3YZJ5_MOUSE UniProtKB/TrEMBL
  D3Z0M3_MOUSE UniProtKB/TrEMBL
  D3Z3N2_MOUSE UniProtKB/TrEMBL
  D3Z490_MOUSE UniProtKB/TrEMBL
  D3Z5X2_MOUSE UniProtKB/TrEMBL
  F8WHG5 ENTREZGENE, UniProtKB/TrEMBL
  Q3TY95 ENTREZGENE, UniProtKB/TrEMBL
  Q60823 ENTREZGENE
  Q8CE74_MOUSE UniProtKB/TrEMBL