Afp (alpha fetoprotein) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Afp (alpha fetoprotein) Mus musculus
Analyze
Symbol: Afp
Name: alpha fetoprotein
RGD ID: 10116
MGI Page MGI
Description: Predicted to enable metal ion binding activity. Acts upstream of or within several processes, including homeostasis of number of cells; ovulation from ovarian follicle; and progesterone metabolic process. Located in cytoplasm and extracellular space. Is expressed in several structures, including egg cylinder; embryo endoderm; gut; liver and biliary system; and metanephros. Human ortholog(s) of this gene implicated in hepatitis C. Orthologous to human AFP (alpha fetoprotein).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: alpha-1-fetoprotein; alpha-fetoglobulin; alpha-fetoprotein; alpha-foetoprotein
RGD Orthologs
Human
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39590,638,573 - 90,656,766 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl590,638,596 - 90,656,766 (+)EnsemblGRCm39 Ensembl
GRCm38590,490,714 - 90,508,907 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl590,490,737 - 90,508,907 (+)EnsemblGRCm38mm10GRCm38
MGSCv37590,919,740 - 90,937,933 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36591,565,937 - 91,584,106 (+)NCBIMGSCv36mm8
Celera588,652,007 - 88,670,199 (+)NCBICelera
Cytogenetic Map5E1NCBI
cM Map544.77NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(+)-taxifolin  (ISO)
(S)-naringenin  (ISO)
1,1-dichloroethene  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
1H-1,2,4-triazole  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2'-Dihydroxy-4-methoxybenzophenone  (ISO)
2,3,4,5-Tetrachloro-4'-biphenylol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4-diaminotoluene  (EXP)
2,4-dinitrotoluene  (ISO)
2-acetamidofluorene  (ISO)
2-amino-2-deoxy-D-galactopyranose  (ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP)
2-nitropropane  (ISO)
2-sec-butylphenol  (ISO)
3'-hydroxyflavanone  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,5,6-trichloro-2-pyridinol  (EXP)
3,5,6-trichloropyridine-2-one  (EXP)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (EXP)
4'-hydroxychalcone  (ISO)
4'-hydroxyflavanone  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxychalcone  (ISO)
4-nonylphenol  (ISO)
4-octylphenol  (ISO)
5-azacytidine  (ISO)
5-fluorouracil  (EXP)
5-hydroxytryptophan  (EXP)
7-hydroxyflavanone  (ISO)
acetic acid  (EXP)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucosamine  (EXP)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (ISO)
allyl alcohol  (EXP,ISO)
alogliptin  (ISO)
alpha-Zearalanol  (ISO)
amiodarone  (EXP)
ammonium chloride  (ISO)
apigenin  (ISO)
arotinoid acid  (ISO)
arsenite(3-)  (EXP)
arsenous acid  (EXP,ISO)
Azaspiracid  (ISO)
azoxystrobin  (ISO)
baicalein  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzyl parahydroxybenzoate  (ISO)
benzylpenicillin  (EXP,ISO)
beta-D-glucosamine  (EXP)
beta-Zearalanol  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bromochloroacetic acid  (EXP)
brucine  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (ISO)
carbon nanotube  (EXP)
carfilzomib  (ISO)
chalcone  (ISO)
CHIR 99021  (ISO)
chloroprene  (EXP)
chlorpromazine  (ISO)
chlorpyrifos  (EXP,ISO)
choline  (EXP,ISO)
Chorionic gonadotropin  (ISO)
chrysin  (ISO)
citral  (ISO)
clofibrate  (EXP)
cobalt atom  (EXP)
cobalt dichloride  (ISO)
cocaine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
corosolic acid  (ISO)
cortisol  (ISO)
coumestrol  (ISO)
Cuprizon  (ISO)
cyclophosphamide  (EXP)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
D-glucose  (EXP)
decabromodiphenyl ether  (ISO)
diarsenic trioxide  (EXP,ISO)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
dienestrol  (ISO)
diethyl maleate  (EXP)
diethyl phthalate  (ISO)
diethylstilbestrol  (EXP,ISO)
Dimethyl phthalate  (ISO)
dimethylarsinic acid  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
ebselen  (ISO)
equol  (ISO)
estra-1,3,5(10)-trien-3-ol  (ISO)
estriol  (EXP,ISO)
estrone  (ISO)
ethanol  (ISO)
fisetin  (ISO)
flavanone  (ISO)
flavonoids  (ISO)
folic acid  (EXP,ISO)
formaldehyde  (ISO)
fosinopril  (EXP)
furan  (EXP,ISO)
gemcitabine  (ISO)
geranial  (ISO)
glucose  (EXP)
glyphosate  (ISO)
hesperidin  (ISO)
hexestrol  (ISO)
hypochlorous acid  (EXP)
imidacloprid  (ISO)
isoliquiritigenin  (ISO)
isoniazide  (ISO)
kaempferol  (EXP,ISO)
ketamine  (ISO)
L-ascorbic acid  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
L-ethionine  (ISO)
L-methionine  (EXP,ISO)
levofloxacin  (ISO)
lipopolysaccharide  (EXP)
losartan  (EXP)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
masoprocol  (ISO)
mercury dibromide  (ISO)
mestranol  (ISO)
methimazole  (EXP,ISO)
methylarsonic acid  (EXP)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
monobenzone  (ISO)
myricetin  (ISO)
N,N'-diphenyl-1,4-phenylenediamine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (ISO)
N-nitrosomorpholine  (ISO)
nickel atom  (EXP)
nickel dichloride  (ISO)
niclosamide  (ISO)
nitrofen  (ISO)
ochratoxin A  (ISO)
ozone  (EXP)
panaxydol  (ISO)
paracetamol  (EXP,ISO)
perfluorooctanoic acid  (ISO)
perindopril  (EXP)
phenobarbital  (EXP,ISO)
phenol  (ISO)
phenylmercury acetate  (ISO)
phenytoin  (EXP,ISO)
phloretin  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
pirinixic acid  (EXP,ISO)
pluronic P-123  (ISO)
Poloxamer  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (EXP,ISO)
quercetin  (ISO)
rotenone  (ISO)
S-adenosyl-L-methioninate  (EXP)
S-adenosyl-L-methionine  (EXP)
saccharin  (EXP)
SB 431542  (ISO)
silver atom  (EXP)
silver(0)  (EXP)
simvastatin  (ISO)
sodium arsenite  (EXP,ISO)
sodium nitrate  (EXP)
sorafenib  (EXP)
streptozocin  (EXP)
succimer  (EXP)
tamoxifen  (EXP)
tetrachloromethane  (EXP,ISO)
thiabendazole  (ISO)
thioacetamide  (ISO)
thiram  (ISO)
thymoquinone  (ISO)
titanium dioxide  (EXP)
trans-chalcone  (ISO)
tributylstannane  (EXP)
trichloroethene  (ISO)
triclosan  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
urea  (ISO)
valproic acid  (EXP,ISO)
XAV939  (ISO)
zinc dichloride  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IDA)
extracellular space  (IDA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Applicability of BALAD score in prognostication of hepatitis B-related hepatocellular carcinoma. Chan SL, etal., J Gastroenterol Hepatol. 2015 Oct;30(10):1529-35. doi: 10.1111/jgh.13005.
2. Serum biomarkers in metastatic renal cell carcinoma. Dexeus FH, etal., Urology. 1991 Jul;38(1):6-10.
3. Bone marrow derived-mesenchymal stem cells downregulate IL17A dependent IL6/STAT3 signaling pathway in CCl4-induced rat liver fibrosis. Farouk S, etal., PLoS One. 2018 Oct 22;13(10):e0206130. doi: 10.1371/journal.pone.0206130. eCollection 2018.
4. Alpha-fetoprotein, the major fetal serum protein, is not essential for embryonic development but is required for female fertility. Gabant P, etal., Proc Natl Acad Sci U S A 2002 Oct 1;99(20):12865-70. Epub 2002 Sep 24.
5. The Clinical Significance of Alpha-Fetoprotein mRNAs in Patients with Hepatocellular Carcinoma. Kobayashi S, etal., Gastrointest Tumors. 2017 Mar;3(3-4):141-152. doi: 10.1159/000455955. Epub 2017 Feb 8.
6. Prognostic analysis of Japanese men with metastatic germ cell tumors showing favorable response to bleomycin, etoposide and cisplatin as first-line chemotherapy. Kumano M, etal., Hinyokika Kiyo. 2007 Dec;53(12):851-6.
7. Elevated serum alpha fetoprotein levels promote pathological progression of hepatocellular carcinoma. Li P, etal., World J Gastroenterol. 2011 Nov 7;17(41):4563-71. doi: 10.3748/wjg.v17.i41.4563.
8. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
9. MGDs mouse GO annotations MGD data from the GO Consortium
10. MGD IEA MGD IEA
11. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
12. Assessment of 54 biomarkers for biopsy-detectable prostate cancer. Parekh DJ, etal., Cancer Epidemiol Biomarkers Prev. 2007 Oct;16(10):1966-72.
13. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
14. Map of seven polymorphic markers on rat chromosome 14: linkage conservation with human chromosome 4. Remmers EF, etal., Mamm Genome 1993;4(2):90-4.
15. Mouse MP Annotation Import Pipeline RGD automated import pipeline
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Synthesis of alpha-fetoprotein and some other serum proteins in testicular tumors. Sakashita S, etal., Invest Urol. 1977 Jul;15(1):2-4.
18. Elevation of serum alpha-fetoprotein and proliferation of oval cells in the livers of LEC rats. Takahashi H, etal., Jpn J Cancer Res. 1988 Jul;79(7):821-7. doi: 10.1111/j.1349-7006.1988.tb00043.x.
19. Direct-acting antiviral-based triple therapy on alpha-fetoprotein level in chronic hepatitis C patients. Takayama K, etal., World J Gastroenterol. 2015 Apr 21;21(15):4696-706. doi: 10.3748/wjg.v21.i15.4696.
20. Surgery in infants and children with testicular and paratesticular tumours: a single centre experience over a 25-year-period. Trobs RB, etal., Klin Padiatr. 2007 May-Jun;219(3):146-51.
21. Prolactin promotes hepatocellular carcinoma through Janus kinase 2. Yeh YT, etal., World J Surg. 2012 May;36(5):1128-35. doi: 10.1007/s00268-012-1505-4.
22. Development of multimarker panel for early detection of endometrial cancer. High diagnostic power of prolactin. Yurkovetsky Z, etal., Gynecol Oncol. 2007 Oct;107(1):58-65. Epub 2007 Jul 19.
23. Garlic Oil Suppressed Nitrosodiethylamine-Induced Hepatocarcinoma in Rats by Inhibiting PI3K-AKT-NF-κB Pathway. Zhang CL, etal., Int J Biol Sci. 2015 Apr 25;11(6):643-51. doi: 10.7150/ijbs.10785. eCollection 2015.
Additional References at PubMed
PMID:67170   PMID:88451   PMID:1282109   PMID:1284040   PMID:1315306   PMID:1353738   PMID:1363228   PMID:1371343   PMID:1372902   PMID:1375227   PMID:1383034   PMID:1397688  
PMID:1421760   PMID:1450512   PMID:1628813   PMID:1647018   PMID:1685890   PMID:1794049   PMID:1846043   PMID:1889815   PMID:1974892   PMID:1979024   PMID:2015789   PMID:2159567  
PMID:2328987   PMID:2328989   PMID:2412765   PMID:2452956   PMID:2456965   PMID:2457811   PMID:2471155   PMID:2495302   PMID:2547683   PMID:2579343   PMID:2654812   PMID:2663644  
PMID:2787378   PMID:3007994   PMID:3200849   PMID:3242495   PMID:3293998   PMID:3405219   PMID:3416641   PMID:3582732   PMID:3857594   PMID:6154931   PMID:6157603   PMID:6161929  
PMID:6161930   PMID:6164927   PMID:6170120   PMID:6170978   PMID:6172714   PMID:6186903   PMID:6199242   PMID:6206473   PMID:6206499   PMID:6278047   PMID:6364482   PMID:6594688  
PMID:6641714   PMID:7509788   PMID:7517187   PMID:7523852   PMID:7525069   PMID:7537233   PMID:7541561   PMID:7624372   PMID:7684942   PMID:7691704   PMID:7830794   PMID:7873878  
PMID:7899085   PMID:8111123   PMID:8180469   PMID:8268909   PMID:8299877   PMID:8380915   PMID:8507985   PMID:8557196   PMID:8562047   PMID:8607965   PMID:8626794   PMID:8668203  
PMID:8682297   PMID:8835525   PMID:8835534   PMID:8914606   PMID:8952527   PMID:9030885   PMID:9136932   PMID:9136933   PMID:9152011   PMID:9158943   PMID:9215907   PMID:9298902  
PMID:9321462   PMID:9420335   PMID:9502734   PMID:9529255   PMID:9545272   PMID:9551868   PMID:9802886   PMID:9876177   PMID:10051313   PMID:10205167   PMID:10349636   PMID:10364163  
PMID:10479460   PMID:10603343   PMID:10652269   PMID:10720432   PMID:10772805   PMID:10804184   PMID:10888866   PMID:10906784   PMID:11000266   PMID:11027604   PMID:11042159   PMID:11076861  
PMID:11165478   PMID:11197537   PMID:11217851   PMID:11230134   PMID:11298452   PMID:11430694   PMID:11438667   PMID:11549270   PMID:11566864   PMID:11731232   PMID:11832378   PMID:11973269  
PMID:12015293   PMID:12105862   PMID:12113675   PMID:12117810   PMID:12118941   PMID:12167706   PMID:12200422   PMID:12215259   PMID:12376107   PMID:12466851   PMID:12477932   PMID:12543979  
PMID:12558604   PMID:12676095   PMID:12819125   PMID:12874218   PMID:12915229   PMID:14615479   PMID:14623818   PMID:14697368   PMID:15005571   PMID:15028291   PMID:15057752   PMID:15175265  
PMID:15183723   PMID:15271968   PMID:15485926   PMID:15489334   PMID:15519652   PMID:15536133   PMID:15578515   PMID:15626755   PMID:15767668   PMID:15959514   PMID:15979417   PMID:16109169  
PMID:16141072   PMID:16141073   PMID:16288022   PMID:16388309   PMID:16467207   PMID:16470614   PMID:16479017   PMID:16510872   PMID:16514630   PMID:16683987   PMID:16708394   PMID:16892179  
PMID:17028112   PMID:17077188   PMID:17425607   PMID:17634284   PMID:18038450   PMID:18171685   PMID:18202134   PMID:18332127   PMID:18356246   PMID:18448090   PMID:18462699   PMID:18478268  
PMID:18554416   PMID:18617288   PMID:18635606   PMID:18669658   PMID:18722179   PMID:18816823   PMID:18854136   PMID:19015022   PMID:19174539   PMID:19185577   PMID:19301403   PMID:19556507  
PMID:19562671   PMID:19733224   PMID:19737349   PMID:19782060   PMID:19786569   PMID:19833122   PMID:19865483   PMID:19896480   PMID:20080598   PMID:20109458   PMID:20161774   PMID:20307648  
PMID:20346354   PMID:20348100   PMID:20506647   PMID:20533405   PMID:20573697   PMID:20609214   PMID:20692235   PMID:20818615   PMID:21084569   PMID:21094155   PMID:21146511   PMID:21216305  
PMID:21267068   PMID:21305474   PMID:21354127   PMID:21541657   PMID:21573244   PMID:21596989   PMID:21670299   PMID:21677750   PMID:21873635   PMID:22260730   PMID:22497843   PMID:22544812  
PMID:22589735   PMID:22874919   PMID:22966238   PMID:22990867   PMID:23431188   PMID:23552073   PMID:23684747   PMID:23746980   PMID:24497168   PMID:25009997   PMID:25153170   PMID:25209997  
PMID:25302779   PMID:25515659   PMID:25860032   PMID:25912690   PMID:26222436   PMID:26494787   PMID:27100146   PMID:27197076   PMID:27904043   PMID:28174238   PMID:28178526   PMID:28193997  
PMID:28258223   PMID:28532839   PMID:28542246   PMID:28838957   PMID:28854362   PMID:29168693   PMID:29408805   PMID:30504829   PMID:30733279   PMID:31112136   PMID:31143371   PMID:31308417  
PMID:31315026   PMID:31555647   PMID:32023452   PMID:32326334   PMID:32883967   PMID:33144666   PMID:33658225   PMID:34248495   PMID:34321999   PMID:34433966   PMID:34599818   PMID:34880251  
PMID:35293576   PMID:35297995   PMID:35512705   PMID:36123357   PMID:36283963   PMID:36301669   PMID:36656901   PMID:37524711   PMID:37633271   PMID:37795611  


Genomics

Comparative Map Data
Afp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39590,638,573 - 90,656,766 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl590,638,596 - 90,656,766 (+)EnsemblGRCm39 Ensembl
GRCm38590,490,714 - 90,508,907 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl590,490,737 - 90,508,907 (+)EnsemblGRCm38mm10GRCm38
MGSCv37590,919,740 - 90,937,933 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36591,565,937 - 91,584,106 (+)NCBIMGSCv36mm8
Celera588,652,007 - 88,670,199 (+)NCBICelera
Cytogenetic Map5E1NCBI
cM Map544.77NCBI
AFP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38473,436,221 - 73,456,174 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl473,431,138 - 73,456,174 (+)EnsemblGRCh38hg38GRCh38
GRCh37474,301,938 - 74,321,891 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36474,520,797 - 74,540,356 (+)NCBINCBI36Build 36hg18NCBI36
Build 34474,666,967 - 74,686,527NCBI
Celera471,661,745 - 71,681,240 (+)NCBICelera
Cytogenetic Map4q13.3ENTREZGENE
HuRef470,113,467 - 70,132,962 (+)NCBIHuRef
CHM1_1474,338,122 - 74,357,615 (+)NCBICHM1_1
T2T-CHM13v2.0476,779,943 - 76,799,830 (+)NCBIT2T-CHM13v2.0
Afp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81417,857,584 - 17,875,645 (-)NCBIGRCr8
mRatBN7.21417,573,412 - 17,591,476 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1417,573,412 - 17,591,480 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1417,559,718 - 17,577,743 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01418,878,645 - 18,896,663 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01417,577,705 - 17,595,633 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01419,141,755 - 19,159,919 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1419,141,755 - 19,159,923 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01419,049,096 - 19,067,260 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41419,092,563 - 19,110,728 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11419,092,562 - 19,110,728 (-)NCBI
Celera1416,939,827 - 16,957,879 (-)NCBICelera
RH 3.4 Map14214.49RGD
Cytogenetic Map14p22NCBI
AFP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2356,607,582 - 56,626,380 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1456,796,622 - 56,815,436 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0450,739,197 - 50,758,459 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1456,571,519 - 56,590,391 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl456,571,519 - 56,590,391 (-)Ensemblpanpan1.1panPan2
AFP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11362,182,876 - 62,203,414 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1362,053,814 - 62,294,709 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1361,852,491 - 61,873,033 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01362,992,405 - 63,012,932 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1362,992,405 - 63,012,932 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11362,603,973 - 62,624,508 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01362,097,020 - 62,117,581 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01363,232,901 - 63,253,687 (+)NCBIUU_Cfam_GSD_1.0
Afp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528513,606,058 - 13,625,722 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365982,058,117 - 2,077,728 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365982,058,474 - 2,077,711 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AFP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl869,677,690 - 69,698,864 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1869,677,690 - 69,698,864 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2873,777,748 - 73,798,926 (+)NCBISscrofa10.2Sscrofa10.2susScr3
AFP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1721,904,225 - 21,924,105 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl721,905,154 - 21,924,092 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666084873,280 - 892,444 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Afp
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473534,072,192 - 34,092,604 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473534,072,257 - 34,092,540 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:55
Count of miRNA genes:51
Interacting mature miRNAs:54
Transcripts:ENSMUST00000042755
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4140990Lgq6_mlate growth QTL 6 (mouse)Not determined32133234100777931Mouse
1301010ahl2_mage related hearing loss 2 (mouse)Not determined56265056896650688Mouse
1301399Cpfd3_mcerebellum pattern fissures (mouse)Not determined587386871121387065Mouse
12910784Pwgrq15_mpost-weaning growth rate QTL 15 (mouse)57717582397658215Mouse
1301524Lmb2_mlupus in MRL and B6 F2 cross (mouse)Not determined537581488112465722Mouse
25314315Mlh1fc4_mMLH1 foci count 4 (mouse)574460661132528839Mouse
1357725Eae39_mexperimental allergic encephalomyelitis 39 (mouse)Not determined589418876118864028Mouse
10045972Tir5_mtrypanosome infection response 5 (mouse)Not determined563705442104387065Mouse
1300993Hycdc_mhypercapnic duty cycle (mouse)Not determined590561006124561151Mouse
1301126Bwem1_mbody weight day 30 males 1 (mouse)Not determined587386871121387065Mouse
4141219W10q16_mweight 10 weeks QTL 16 (mouse)Not determined32133234100777931Mouse
12910816Ogrq2_moverall growth rate QTL 2 (mouse)57717582397658215Mouse
1301691Cdcs10_mcytokine deficiency colitis susceptibility 10 (mouse)Not determined576280786110280917Mouse
11041665Lmr24_mleishmaniasis resistance 24 (mouse)552694462107321041Mouse
10043958Chldq12_mcholesterol and HDL QTL 12 (mouse)Not determined587386871121387065Mouse
26884395Humsd2_mhumerus midshaft diameter 2, 10 week (mouse)570057343132528839Mouse
11252124Modvl6_mmodifier of vacuolated lens 6 (mouse)56265056896650688Mouse
1301419Cypr3_mcytokine production 3 (mouse)Not determined581019649115019803Mouse
11341716Rvfs3_mRift Valley fever susceptibility 3 (mouse)526441234138455402Mouse
13506928Recrq8_mrecombination rate in male meiosis QTL 8 (mouse)574460661132528839Mouse
1301843Listr1_mlisteriosis resistance 1 (mouse)Not determined56024608194246203Mouse
10043993Hbnr10_mHeligmosomoides bakeri nematode resistance 10 (mouse)Not determined572418876106419011Mouse
27226719Tibw6_mtibia width 6, proximal, 16 week (mouse)572857343139985755Mouse
10401246Bglu13_mblood glucose level 13 (mouse)Not determined579539640113539786Mouse
4141438Skmw13_mskeletal muscle weight 13 (mouse)Not determined576190263110190479Mouse
1301713Dbsty2_mdiabesity 2 (mouse)Not determined576445064110445225Mouse
1301457Cfsw2_mcystic fibrosis survival to weaning 2 (mouse)Not determined590561006124561151Mouse
11041899Lmr24a_mleishmaniasis resistance 24a (mouse)552694462107321041Mouse
10401245Bglu18_mblood glucose level 18 (mouse)Not determined582838468116838597Mouse
4142064Tmc1m4_mTmc1 modifier 4 (mouse)Not determined554500177127001072Mouse
1300931Cocrb6_mcocaine related behavior 6 (mouse)Not determined576445064110445225Mouse
4142317Rgcs1_mretinal ganglion cell susceptible 1 (mouse)Not determined55388334108762627Mouse
1300801Drb2_mdopamine receptor binding 2 (mouse)Not determined587386871121387065Mouse
1301829Thyls2_mthymic lymphoma susceptibility 2 (mouse)Not determined576445064110445225Mouse
12904740M1fscn2_mmodifier 1 of Fscn2 (mouse)566529661100529661Mouse
10755524Mono1_mmonocyte differential 1 (mouse)580849259114849259Mouse
1301362Prnr1_mprion resistance 1 (mouse)Not determined589418876146787935Mouse
4142428Modvl1_mmodifier of vacuolated lens 1 (mouse)Not determined6265056896650688Mouse
1357431Cia27_mcollagen induced arthritis 27 (mouse)Not determined575315348120018629Mouse
11040589Lmr3a_mleishmaniasis resistance 3a (mouse)55960280193602980Mouse
11040590Lmr3b_mleishmaniasis resistance 3b (mouse)55960280193602980Mouse
11040591Lmr3c_mleishmaniasis resistance 3c (mouse)55960280193602980Mouse
12904739M2fscn2_mmodifier 2 of FSCN2 (mouse)566529661100529661Mouse
1301243Bmd2_mbone mineral density 2 (mouse)Not determined555388334100455525Mouse
1300986Hdlq2_mHDL QTL 2 (mouse)Not determined576280786110280917Mouse
11049560Lmr24d_mleishmaniasis resistance 24d (mouse)56437487798374996Mouse
11049562Lmr24f_mleishmaniasis resistance 24f (mouse)590320962124321041Mouse
13464249Ahl16_mage related hearing loss, early onset 16 (mouse)576445064110445225Mouse
13464250Ahl15_mage related hearing loss, early onset 15 (mouse)56265056896650688Mouse
11040592Lmr3d_mleishmaniasis resistance 3d (mouse)55960280193602980Mouse
13464247Ahl14_mage related hearing loss, early onset 14 (mouse)56040306294403160Mouse
4141124Dshv2_mdorsal hippocampal volume 2 (mouse)Not determined57531534898019803Mouse
1300968Skts4_mskin tumor susceptibility 4 (mouse)Not determined589418876124238239Mouse
10044005Ahl7_mage related hearing loss 7 (mouse)Not determined55833050292330641Mouse
13464241Ahl18_mage related hearing loss, early onset 18 (mouse)587386871121387065Mouse
4141505Chlq14_mcirculating hormone level QTL 14 (mouse)Not determined576280786110280917Mouse
13464242Ahl17_mage related hearing loss, early onset 17 (mouse)582838468116838597Mouse

Markers in Region
Afp  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv37590,935,628 - 90,936,854UniSTSGRCm37
MGSCv37590,919,944 - 90,920,027UniSTSGRCm37
MGSCv37590,937,474 - 90,937,838UniSTSGRCm37
MGSCv37590,920,739 - 90,921,727UniSTSGRCm37
Celera588,669,740 - 88,670,104UniSTS
Celera588,667,894 - 88,669,120UniSTS
Celera588,652,211 - 88,652,294UniSTS
Celera588,653,006 - 88,653,994UniSTS
Cytogenetic Map5E1UniSTS
cM Map550.0UniSTS
V00743  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38590,508,734 - 90,508,818UniSTSGRCm38
MGSCv37590,937,760 - 90,937,844UniSTSGRCm37
Celera588,670,026 - 88,670,110UniSTS
Cytogenetic Map5E1UniSTS
cM Map550.0UniSTS
Whitehead/MRC_RH51107.82UniSTS
PMC219482P3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38590,490,626 - 90,490,706UniSTSGRCm38
MGSCv37590,919,652 - 90,919,732UniSTSGRCm37
Celera588,651,919 - 88,651,999UniSTS
Cytogenetic Map5E1UniSTS
cM Map550.0UniSTS
Afp  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5E1UniSTS
Afp  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38590,506,685 - 90,507,902UniSTSGRCm38
Celera588,667,977 - 88,669,194UniSTS
Cytogenetic Map5E1UniSTS
Afp  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38590,506,602 - 90,507,828UniSTSGRCm38
MGSCv37590,935,628 - 90,936,854UniSTSGRCm37
Celera588,667,894 - 88,669,120UniSTS
Cytogenetic Map5E1UniSTS
Afp  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5E1UniSTS
Afp  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38590,508,448 - 90,508,812UniSTSGRCm38
MGSCv37590,937,474 - 90,937,838UniSTSGRCm37
Celera588,669,740 - 88,670,104UniSTS
Cytogenetic Map5E1UniSTS
Afp  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38590,490,918 - 90,491,001UniSTSGRCm38
MGSCv37590,919,944 - 90,920,027UniSTSGRCm37
Celera588,652,211 - 88,652,294UniSTS
Cytogenetic Map5E1UniSTS
cM Map550.0UniSTS
Afp  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5E1UniSTS
cM Map550.0UniSTS
Afp  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38590,491,713 - 90,492,701UniSTSGRCm38
MGSCv37590,920,739 - 90,921,727UniSTSGRCm37
Celera588,653,006 - 88,653,994UniSTS
Cytogenetic Map5E1UniSTS
cM Map550.0UniSTS
Afp  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5E1UniSTS
Afp  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5E1UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_007423 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC140220 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH001842 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK010934 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK075972 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK076053 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK076197 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK145975 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK146513 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK146524 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK167549 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK168426 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK168574 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK168576 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK168751 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK168818 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK168883 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK169046 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK169054 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK169147 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AV105248 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC066206 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY773400 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466617 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  V00743 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X87098 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000042755   ⟹   ENSMUSP00000041006
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl590,638,596 - 90,656,766 (+)Ensembl
GRCm38.p6 Ensembl590,490,737 - 90,508,907 (+)Ensembl
Ensembl Acc Id: ENSMUST00000200693   ⟹   ENSMUSP00000144019
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl590,638,598 - 90,643,912 (+)Ensembl
GRCm38.p6 Ensembl590,490,739 - 90,496,053 (+)Ensembl
Ensembl Acc Id: ENSMUST00000200728
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl590,649,390 - 90,652,028 (+)Ensembl
GRCm38.p6 Ensembl590,501,531 - 90,504,169 (+)Ensembl
Ensembl Acc Id: ENSMUST00000201061
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl590,639,097 - 90,643,962 (+)Ensembl
GRCm38.p6 Ensembl590,491,238 - 90,496,103 (+)Ensembl
Ensembl Acc Id: ENSMUST00000202209
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl590,655,290 - 90,656,711 (+)Ensembl
GRCm38.p6 Ensembl590,507,431 - 90,508,852 (+)Ensembl
RefSeq Acc Id: NM_007423   ⟹   NP_031449
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39590,638,573 - 90,656,766 (+)NCBI
GRCm38590,490,714 - 90,508,907 (+)ENTREZGENE
MGSCv37590,919,740 - 90,937,933 (+)RGD
Celera588,652,007 - 88,670,199 (+)RGD
cM Map5 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_031449   ⟸   NM_007423
- Peptide Label: precursor
- UniProtKB: Q3UJD0 (UniProtKB/Swiss-Prot),   P02772 (UniProtKB/Swiss-Prot),   Q8BK56 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000041006   ⟸   ENSMUST00000042755
Ensembl Acc Id: ENSMUSP00000144019   ⟸   ENSMUST00000200693
Protein Domains
Albumin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P02772-F1-model_v2 AlphaFold P02772 1-605 view protein structure

Promoters
RGD ID:6887112
Promoter ID:EPDNEW_M7007
Type:multiple initiation site
Name:Afp_1
Description:Mus musculus alpha fetoprotein , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38590,490,739 - 90,490,799EPDNEW
RGD ID:6849592
Promoter ID:EP16045
Type:single initiation site
Name:MM_FETA
Description:alpha-fetoprotein, AFP gene.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Notes:homology_group=Homology group 92; Mammalian alpha-fetoprotein
Tissues & Cell Lines:fetus, liver
Experiment Methods:Nuclease protection with homologous sequence ladder
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv37590,919,763 - 90,919,823EPD
MGSCv36590,919,763 - 90,919,823EPD

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:87951 AgrOrtholog
Ensembl Genes ENSMUSG00000054932 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000042755 ENTREZGENE
  ENSMUST00000042755.7 UniProtKB/Swiss-Prot
  ENSMUST00000200693.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.246.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ALB/AFP/VDB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Serum_albumin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Serum_albumin/AFP/Afamin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Serum_albumin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Serum_albumin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:11576 UniProtKB/Swiss-Prot
MGD MGI:87951 ENTREZGENE
NCBI Gene 11576 ENTREZGENE
PANTHER ALPHA-FETOPROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11385 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Serum_albumin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Afp PhenoGen
PIRSF Serum_albumin_subgroup UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS AFETOPROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SERUMALBUMIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ALBUMIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ALBUMIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART ALBUMIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48552 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0J9YU60_MOUSE UniProtKB/TrEMBL
  FETA_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3TGA3_MOUSE UniProtKB/TrEMBL
  Q3UJD0 ENTREZGENE
  Q8BK56 ENTREZGENE, UniProtKB/TrEMBL
  Q8BK65_MOUSE UniProtKB/TrEMBL
UniProt Secondary Q3UJD0 UniProtKB/Swiss-Prot