Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

Cell Line : CVCL_0019 (SH-SY5Y) Homo sapiens

Symbol: CVCL_0019
Name: SH-SY5Y
Cell Line Type: cancer cell line
Origin: Derived from metastatic site: Bone marrow.
Gender: Female
Source: From: Memorial Sloan Kettering Cancer Center; New York; USA
Research Use: Omics: Deep antibody staining analysis; Omics: Deep exome analysis; Omics: Deep proteome analysis; Omics: Deep tyrosine phosphoproteome analysis; Omics: Deep RNAseq analysis; Omics: GPI-anchored proteins analysis by proteomics; Omics: Mitochondrial proteome analysis by 2D-DE/MS; Omics: N-glycan profiling; Omics: SNP array analysis; Omics: Transcriptome analysis
Characteristics: Characteristics: Neuroblastic type (N-type) (PubMed=15720811); Characteristics: There seems to be differences in the retinoic acid (RA)-induced neuronal phenotype of SH-SY5Y cells from ATCC and ECACC After 5 days of RA treatment, ECACC cells are slightly larger in size and contains significant amount of neuroblastic (N-type) cells and a small fraction of epithelial (S-type) cells (PubMed=18957096).
Phenotype: Doubling time: >55 hours (DSMZ)
Genomic Alteration: Sequence variation: ALK p.Phe1174Leu (c.3522C>A) (ClinVar=VCV000217852) (PubMed=28350380)
Caution: Problematic cell line: Partially contaminated Some laboratories that are redistributing this cell line are in fact redistributing a contaminated cell line of mouse origin (PubMed=25182563).
Groups: Part of: Cancer Cell Line Encyclopedia (CCLE) project; Part of: ENCODE project common cell types; tier 3; Registration: Memorial Sloan Kettering Cancer Center Office of Technology Development; SK 810
Description: Genome ancestry: African=0%; Native American=1.17%; East Asian, North=0.35%; East Asian, South=0.1%; South Asian=0.08%; European, North=69.09%; European, South=29.2% (PubMed=30894373)
Derived From Cell Lines: CVCL_0531 (SK-N-SH)
Child Cell Lines: CVCL_0523 (SH-SY5Y-SPA4CT)
CVCL_5I52 (SH-SY5Y-HFE)
CVCL_5I53 (SH-SY5Y-HFE C282Y)
CVCL_5I54 (SH-SY5Y-HFE H63D)
CVCL_RR53 (SH-SY5YrVCR10)
CVCL_RR81 (SH-SY5YrCDDP200)
CVCL_RS23 (SH-SY5YrCDDP500)
CVCL_RS81 (SH-SY5YrDOX20)
CVCL_RS8O (SH-SY5YrDOX10)
CVCL_U924 (SH-SY5Y Rho0 64/5)
CVCL_UJ94 (SH-SY5Y-TrkA, clone P23A)
CVCL_UJ95 (SH-SY5Y-TrkB, clone BR6)
CVCL_UJ96 (SH-SY5Y-pLNCX2 empty vector)
CVCL_VA24 (SHSY5Y-B7H6)
CVCL_YJ70 (VAMPIRO SH-SY5Y)
CVCL_YJ91 (LINTERNA SH-SY5Y)
CVCL_YK67 (SH-SY5Y TagGFP2-SNCA)
CVCL_ZL49 (SH-SY5Y/VCR)
Aliases: SH-SY5; SH-Sy5y; SH-SY5Y Parental; SHSY-5Y; SHSY5Y; SK-SH-SY5Y; SY5Y
Disease(s): neuroblastoma (DOID:769) [NCI:C3270,ORDO:635]


References

References - uncurated

Additional Information

External Database Links
 
RGD Object Information
RGD ID: 21113481
Created: 2020-02-27
Species: Homo sapiens
Last Modified: 2020-02-27
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.