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Cell Line : CVCL_0014 (RPMI-8226) Homo sapiens

Symbol: CVCL_0014
Name: RPMI-8226
Cell Line Type: cancer cell line
Origin: Derived from sampling site: Peripheral blood.
Gender: Male
Research Use: Omics: Array-based CGH; Omics: CNV analysis; Omics: Deep antibody staining analysis; Omics: Deep exome analysis; Omics: Deep proteome analysis; Omics: Deep quantitative proteome analysis; Omics: Deep RNAseq analysis; Omics: DNA methylation analysis; Omics: Fluorescence phenotype profiling; Omics: lncRNA expression profiling; Omics: Metabolome analysis; Omics: Protein expression by reverse-phase protein arrays; Omics: SNP array analysis; Omics: Transcriptome analysis
Characteristics: Characteristics: Produces IgG lambda
Phenotype: Doubling time: 60 hours (PubMed=25984343); 33.5 hours (NCI-DTP); ~60-70 hours (DSMZ); Microsatellite instability: Stable (MSS) (Sanger)
Genomic Alteration: Sequence variation: Heterozygous for EGFR p.Thr751Ile (c.2252C>T) (PubMed=17088437); Sequence variation: Heterozygous for KRAS p.Gly12Ala (c.35G>C) (PubMed=11157491; PubMed=12068308; PubMed=17088437; PubMed=21173094); Sequence variation: Homozygous for TP53 p.Glu285Lys (c.853G>A) (ClinVar=VCV000420133); temperature-sensitive (PubMed=17088437; PubMed=18277095; PubMed=21173094); Sequence variation: TRAF3 p.Lys191Leufs*60 (PubMed=17692805)
Groups: Part of: Cancer Cell Line Encyclopedia (CCLE) project; Part of: COSMIC cell lines project; Part of: LL-100 blood cancer cell line panel; Part of: MD Anderson Cell Lines Project; Part of: NCI-60 cancer cell line panel; Part of: NCI-7 clinical proteomics reference material cell line panel
Description: HLA typing: A*30:01,68:02; B*15:03,15:10; C*02:02:04,03:04:02; DPB1*01:01:02,13:01; DQB1*02:01,02:02; DRB1*03:01:01,07:01 (PubMed=15748285); HLA typing: A*30,68:02; B*15,15; C*02:02,03:04 (Direct_author_submission); Genome ancestry: African=73.94%; Native American=0%; East Asian, North=1.06%; East Asian, South=0%; South Asian=0%; European, North=11.76%; European, South=13.24% (PubMed=30894373)
Notes: Miscellaneous: HLA typing from personal communication of Pellat-Deceunynck C
Child Cell Lines: CVCL_1862 (COLO 677)
CVCL_1996 (COLO 775)
CVCL_3732 (KR-12)
CVCL_4V90 (RPMI-8226/MR4)
CVCL_9V32 (B6B11)
CVCL_J431 (RPMI-8226/Dox40)
CVCL_J432 (RPMI-8226/Dox6)
CVCL_J434 (RPMI-8226/LR-5)
CVCL_XK17 (RPMI-8226-R)
Aliases: 8226; 8226/S; GM 2132; GM02132; GM02132C; GM2132; Roswell Park Memorial Institute 8226; RPMI #8226; RPMI 8226; RPMI 8226/S; RPMI no 8226; RPMI no. 8226; RPMI-8226S; RPMI-8266; RPMI-8826; RPMI.8226; RPMI8226; RPMI8226/S; Simpson
Disease(s): multiple myeloma (DOID:9538) [NCI:C3242,ORDO:29073]


References - uncurated

Additional Information

External Database Links
RGD Object Information
RGD ID: 21113478
Created: 2020-02-27
Species: Homo sapiens
Last Modified: 2020-02-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.