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Cell Line : CVCL_0013 (MOLT-4) Homo sapiens

Symbol: CVCL_0013
Name: MOLT-4
Cell Line Type: cancer cell line
Origin: Derived from sampling site: Peripheral blood.
Gender: Male
Research Use: Omics: Array-based CGH; Omics: CNV analysis; Omics: Deep antibody staining analysis; Omics: Deep exome analysis; Omics: Deep proteome analysis; Omics: Deep RNAseq analysis; Omics: DNA methylation analysis; Omics: Fluorescence phenotype profiling; Omics: lncRNA expression profiling; Omics: Metabolome analysis; Omics: Protein expression by reverse-phase protein arrays; Omics: SNP array analysis; Omics: Transcriptome analysis
Phenotype: Doubling time: 31.56 +- 1.49 hours (PubMed=24762992); 33 hours (PubMed=17117183); 29 hours (PubMed=20922763); 27.9 hours (NCI-DTP); ~40 hours (DSMZ); 24-48 hours (CLS); Microsatellite instability: Instable (MSI-high) (PubMed=31068700; Sanger)
Genomic Alteration: Sequence variation: Heterozygous for NOTCH1 p.Leu1600Pro (c.4799T>C) and p.Pro2514fs*4 (c.7541_7542delCT) (PubMed=15472075); Sequence variation: Heterozygous for NRAS p.Gly12Cys (c.34G>T) (PubMed=1206830; PubMed=17088437); Sequence variation: Homozygous for PTEN p.Lys267fs*9 (c.800delA) (PubMed=17088437); Sequence variation: Heterozygous for STK11 p.Gln214Ter (c.640C>T) (PubMed=17088437); Sequence variation: Heterozygous for TP53 p.Arg306Ter (c.916C>T) (ClinVar=VCV000142144) (PubMed=17088437)
Groups: Part of: 12th International Histocompatibility Workshop (12IHW) cell line panel; Part of: Cancer Cell Line Encyclopedia (CCLE) project; Part of: COSMIC cell lines project; Part of: LL-100 blood cancer cell line panel; Part of: MD Anderson Cell Lines Project; Part of: NCI Pediatric Preclinical Testing Program (PPTP) cell line panel; Part of: NCI-60 cancer cell line panel
Description: HLA typing: A*01:01:01,25:01; B*18,57:01:01; C*06:02,12:03:01; DPB1*02:01:02; DQB1*02:02,03:01:01; DRB1*07,12 (PubMed=15748285); HLA typing: A*01:01:01:01,25:01; B*57:01:01,18:01; C*06:02,12:03; DPA1*01:03; DPB1*02:01:02; DRB1*07,12:01 (IPD-IMGT/HLA; 11094); Genome ancestry: African=0.38%; Native American=0%; East Asian, North=1.74%; East Asian, South=0%; South Asian=0.94%; European, North=68.08%; European, South=28.87% (PubMed=30894373)
Child Cell Lines: CVCL_2657 (NH17)
CVCL_2792 (MOLT-4F)
CVCL_5J16 (MOLT-4-luc2)
CVCL_F827 (MOLT-4 clone 8)
CVCL_M771 (M311)
Originate from same individual as: CVCL_0624 (MOLT-3)
Aliases: GM02219; GM02219C; GM02219D; GM2219C; MOLT 4; Molt-4; MOLT.4; MOLT4
Disease(s): T-cell adult acute lymphocytic leukemia (DOID:5602) [NCI:C9142]


References - uncurated

Additional Information

External Database Links
RGD Object Information
RGD ID: 21113475
Created: 2020-02-27
Species: Homo sapiens
Last Modified: 2020-02-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.