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Cell Line : CVCL_0007 (U-937) Homo sapiens

Symbol: CVCL_0007
Name: U-937
Cell Line Type: cancer cell line
Origin: Derived from sampling site: Pleural effusion.
Gender: Male
Research Use: Omics: Deep antibody staining analysis; Omics: Deep exome analysis; Omics: Deep proteome analysis; Omics: Deep quantitative proteome analysis; Omics: Deep RNAseq analysis; Omics: DNA methylation analysis; Omics: Proteome analysis by 2D-DE/MS; Omics: SNP array analysis; Omics: Transcriptome analysis
Availability: Discontinued: ATCC; CRL-1593; true; Discontinued: RCB; RCB1978; true; Discontinued: TKG; TKG 0279; probable
Characteristics: Characteristics: Can be induced to differentiate into macrophages by several factors such as phorbol ester (PMA) and 12-O-tetradecanoyl-13-phorbol acetate (TPA)
Phenotype: Doubling time: 95-100 hours (PubMed=178611); ~30-40 hours (DSMZ)
Genomic Alteration: Sequence variation: PICALM-MLLT10 (CALM-AF10) gene fusion (PubMed=8643484; PubMed=25485619); Sequence variation: Hemizygous for PTEN p.Gly129fs*51 (c.387_388insCGCC) (PubMed=10966170; CCLE); Sequence variation: Homozygous for TP53 c.559+1G>A (p.Val173Trpfs*59); splice donor mutation (PubMed=1571549; CCLE)
Groups: Group: Space-flown cell line (cellonaut); Part of: Cancer Cell Line Encyclopedia (CCLE) project; Part of: LL-100 blood cancer cell line panel
Description: HLA typing: DRB1*16:01 (IPD-IMGT/HLA; 11507); Genome ancestry: African=0%; Native American=0%; East Asian, North=2.39%; East Asian, South=0%; South Asian=0%; European, North=71.54%; European, South=26.06% (PubMed=30894373)
Notes: Anecdotal: Have been flown in space on shuttle flight STS-76 and on Shenzhou-8 to study growth and cytoskeletal changes in microgravity (PubMed=10352142; DOI=10.1016/j.actaastro.2013.06.007)
Child Cell Lines: CVCL_1775 (TUR)
CVCL_2082 (JOSK-I)
CVCL_2083 (JOSK-M)
CVCL_2810 (U-937 cl1-14)
CVCL_2811 (U-937 cl1-22)
CVCL_2Z95 (U937-DC-SIGN)
CVCL_3680 (EL 1)
CVCL_4V23 (U937/ara-C)
CVCL_6444 (SC)
CVCL_8141 (JOSK-K)
CVCL_8142 (JOSK-S)
CVCL_8442 (MOBS-1)
CVCL_8466 (YAA)
CVCL_8467 (YAP)
CVCL_8765 (U-937 DE-4)
CVCL_8927 (U937(CD59+))
CVCL_8932 (U937(CD59-))
CVCL_9997 (SAML-1)
CVCL_L107 (PH [Human])
CVCL_M769 (U1/HIV-1)
CVCL_M770 (U38)
CVCL_U631 (U-937 GTB)
CVCL_WV55 (U-937/CR)
CVCL_WV56 (U-937 RERC)
CVCL_X000 (U-937-AG)
CVCL_X608 (U937/HIV-2MS)
CVCL_Y170 (U937/clone21)
CVCL_Y171 (U937/clone36)
CVCL_Y172 (U937/clone41)
CVCL_Y173 (U937/clone49)
CVCL_Y174 (U937/UK110)
CVCL_Y175 (U937/UK711)
Aliases: U 937; U937
Disease(s): adult acute monocytic leukemia (DOID:0080149) [NCI:C8263]


References - uncurated

Additional Information

External Database Links
RGD Object Information
RGD ID: 21113451
Created: 2020-02-27
Species: Homo sapiens
Last Modified: 2020-02-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.