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Cell Line : CVCL_0005 (NB4) Homo sapiens

Symbol: CVCL_0005
Name: NB4
Cell Line Type: cancer cell line
Origin: Derived from sampling site: Bone marrow.
Gender: Female
Research Use: Omics: Cell surface proteome; Omics: Deep antibody staining analysis; Omics: Deep exome analysis; Omics: Deep RNAseq analysis; Omics: DNA methylation analysis; Omics: H3K4me3 ChIP-seq epigenome analysis; Omics: shRNA library screening; Omics: SNP array analysis; Omics: Transcriptome analysis
Phenotype: Doubling time: 36-40 hours (PubMed=1995093); 30 hours (PubMed=25984343); ~35-45 hours (DSMZ); Microsatellite instability: Stable (MSS) (Sanger)
Genomic Alteration: Sequence variation: PML-RARA gene fusion (PubMed=12353268; PubMed=15843827); Sequence variation: Heterozygous for KRAS p.Ala18Asp (c.53C>A) (CCLE; Cosmic-CLP); Sequence variation: Homozygous for TP53 p.Arg248Gln (c.743G>A) (ClinVar=VCV000012356) (Cosmic-CLP)
Groups: Part of: Cancer Cell Line Encyclopedia (CCLE) project; Part of: COSMIC cell lines project; Part of: ENCODE project common cell types; tier 3; Part of: LL-100 blood cancer cell line panel; Registration: International Depositary Authority, Deutsche Sammlung von Mikroorganismen und Zellkulturen (DSMZ); ACC-2030; Registration: International Depositary Authority, Pasteur Institute Collection Nationale de Cultures de Micro-organismes (CNCM); I-1045
Description: Genome ancestry: African=3.99%; Native American=0%; East Asian, North=4.75%; East Asian, South=0%; South Asian=0%; European, North=49.28%; European, South=41.98% (PubMed=30894373)
Child Cell Lines: CVCL_8811 (NB4-LR1)
CVCL_U080 (NB4-AsR)
CVCL_U082 (NB4/As)
CVCL_U083 (NB4.007/6)
CVCL_U084 (NB4.306)
CVCL_U085 (NB4-DR1)
CVCL_U086 (NB4-S1)
CVCL_U112 (NB4.437r)
CVCL_VV77 (NB4-A1)
CVCL_VV78 (NB4-B1)
CVCL_VV79 (NB4-D5)
Aliases: NB-4; NB.4
Disease(s): acute promyelocytic leukemia (DOID:0060318) [NCI:C3182,ORDO:520]


References - uncurated

Additional Information

External Database Links
RGD Object Information
RGD ID: 21113449
Created: 2020-02-27
Species: Homo sapiens
Last Modified: 2020-02-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.