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Cell Line : CVCL_0006 (THP-1) Homo sapiens

Symbol: CVCL_0006
Name: THP-1
Cell Line Type: cancer cell line
Origin: Derived from sampling site: Peripheral blood.
Gender: Male
Research Use: Omics: Deep antibody staining analysis; Omics: Deep exome analysis; Omics: Deep promoter analysis; Omics: Deep quantitative proteome analysis; Omics: Deep RNAseq analysis; Omics: DNA methylation analysis; Omics: Glycoproteome analysis by proteomics; Omics: Protein expression by reverse-phase protein arrays; Omics: shRNA library screening; Omics: SNP array analysis; Omics: Transcriptome analysis
Characteristics: Characteristics: Can differentiate from monocytes into macrophage-like cells upon stimulation with PMA
Phenotype: Doubling time: 60-70 hours (PubMed=6970727); 26 hours (PubMed=25984343); ~35-50 hours (DSMZ); Microsatellite instability: Stable (MSS) (Sanger)
Genomic Alteration: Sequence variation: CSNK2A1-DDX39B gene fusion (PubMed=31160637); Sequence variation: KMT2A-MLLT3 (MLL-MLLT3; MLL-AF9) gene fusion (PubMed=11066077; PubMed=15843827); Sequence variation: Heterozygous for NRAS p.Gly12Asp (c.35G>A) (ClinVar=VCV000039648) (PubMed=12068308; ATCC; CCLE; Cosmic-CLP); Sequence variation: Heterozygous for TP53 p.Arg174fs*3 (c.520_545del26) (PubMed=1571549; CCLE)
Caution: Caution: NRAS mutation indicated incorrectly as being p.Gly12Ser in PubMed=9379676
Groups: Group: Space-flown cell line (cellonaut); Part of: Cancer Cell Line Encyclopedia (CCLE) project; Part of: COSMIC cell lines project; Part of: LL-100 blood cancer cell line panel; Part of: MD Anderson Cell Lines Project; Part of: RAS genetic alteration cell panel (ATCC TCP-1031); Part of: Tumor Immunology Bank (TIB) collection from Salk (transferred to ATCC in 1981)
Description: HLA typing: A*02; B*15:11; C*03; DQB1*05,06; DRB1*01,15; DRB5*01/02 (PubMed=22674354); Genome ancestry: African=0%; Native American=0.3%; East Asian, North=77.63%; East Asian, South=20.4%; South Asian=1.67%; European, North=0%; European, South=0% (PubMed=30894373)
Notes: Anecdotal: Have been flown in space on Cosmos-2044 to study the inhibition of phorbol ester-induced cell activation in microgravity (PubMed=352912)
Child Cell Lines: CVCL_0R21 (THP-1/DC-SIGN)
CVCL_0R25 (THP-1(NCI))
CVCL_3426 (THP-1h)
CVCL_3427 (THP-1l)
CVCL_4V22 (THP-1/ara-C)
CVCL_5115 (A-THP-1)
CVCL_5I76 (THP1-defCASP1)
CVCL_DF52 (THP-1 NucLight Red)
CVCL_KB46 (CellSensor NFkB-bla THP-1)
CVCL_KS29 (CellSensor SIE-bla THP-1)
CVCL_KS30 (CellSensor TNFalpha-bla THP-1)
CVCL_KZ70 (PathHunter THP-1 IkappaB Degradation)
CVCL_X582 (THP1-Xblue)
CVCL_X585 (THP1-Blue NF-kappaB)
CVCL_X587 (THP1-Lucia ISG)
CVCL_X588 (THP1-Blue ISG)
CVCL_X590 (THP1-Lucia NF-kappaB)
CVCL_X598 (THP1-defASC)
CVCL_X599 (THP1-Dual)
CVCL_X600 (THP1-defNLRP3)
CVCL_X601 (THP1-Null)
CVCL_X687 (BF24)
CVCL_XD94 (THP-1/IL15)
CVCL_XD95 (THP-1/IL21)
CVCL_XI47 (THP-1 TLR9 mCherry)
CVCL_XZ65 (THP-1 NF-kb luciferase reporter)
Aliases: THP 1; THP-1(ATCC); THP1; THPI; Tohoku Hospital Pediatrics-1


References - uncurated

Additional Information

External Database Links
RGD Object Information
RGD ID: 21113448
Created: 2020-02-27
Species: Homo sapiens
Last Modified: 2020-02-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.