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Cell Line : CVCL_0004 (K-562) Homo sapiens

Symbol: CVCL_0004
Name: K-562
Cell Line Type: cancer cell line
Origin: Derived from sampling site: Pleural effusion.
Gender: Female
Research Use: Omics: Array-based CGH; Omics: CNV analysis; Omics: Deep antibody staining analysis; Omics: Deep exome analysis; Omics: Deep proteome analysis; Omics: Deep quantitative phosphoproteome analysis; Omics: Deep quantitative proteome analysis; Omics: Deep RNAseq analysis; Omics: DNA methylation analysis; Omics: Fluorescence phenotype profiling; Omics: Genome sequenced; Omics: H2A.Z; ChIP-seq epigenome analysis; Omics: H3K27ac ChIP-seq epigenome analysis; Omics: H3K27me3 ChIP-seq epigenome analysis; Omics: H3K36me3 ChIP-seq epigenome analysis; Omics: H3K4me1 ChIP-seq epigenome analysis; Omics: H3K4me2 ChIP-seq epigenome analysis; Omics: H3K4me3 ChIP-seq epigenome analysis; Omics: H3K79me2 ChIP-seq epigenome analysis; Omics: H3K9ac ChIP-seq epigenome analysis; Omics: H3K9me1 ChIP-seq epigenome analysis; Omics: H3K9me3 ChIP-seq epigenome analysis; Omics: H4K20me1 ChIP-seq epigenome analysis; Omics: Pol2; ChIP-seq epigenome analysis; Omics: lncRNA expression profiling; Omics: Metabolome analysis; Omics: Protein expression by reverse-phase protein arrays; Omics: shRNA library screening; Omics: SNP array analysis; Omics: Transcriptome analysis; Omics: Virome analysis using proteomics
Phenotype: Doubling time: 47 hours (PubMed=25984343); 19.6 hours (NCI-DTP); ~30-40 hours (DSMZ); Microsatellite instability: Stable (MSS) (PubMed=23671654; Sanger)
Genomic Alteration: Sequence variation: BCR-ABL1 gene fusion (PubMed=12506034); Sequence variation: Homozygous for TP53 p.Gln136fs*13 (c.406_407insC) (PubMed=17088437; PubMed=18277095)
Groups: Part of: Cancer Cell Line Encyclopedia (CCLE) project; Part of: COSMIC cell lines project; Part of: ENCODE project common cell types; tier 1; Part of: LL-100 blood cancer cell line panel; Part of: MD Anderson Cell Lines Project; Part of: NCI-60 cancer cell line panel
Description: HLA typing: A*11:01:01,31:01:02; B*18,40; C*03; DPB1*04:01,04:02; DQB1*02:01,03:02; DRB1*03,04 (PubMed=15748285); HLA typing: A*11; B*40,35/39; C*05,03 (PubMed=25960936); Genome ancestry: African=5.19%; Native American=0%; East Asian, North=8.4%; East Asian, South=0%; South Asian=0%; European, North=43.44%; European, South=42.97% (PubMed=30894373)
Child Cell Lines: CVCL_0368 (K562/A02)
CVCL_0369 (K562YO)
CVCL_1G55 (EGFP-K562)
CVCL_1Q81 (PC-MDS)
CVCL_2200 (SPI-801)
CVCL_2201 (SPI-802)
CVCL_2697 (PUTKO)
CVCL_2967 (K562 AZQR)
CVCL_2968 (K562 cl.6)
CVCL_3000 (KO51)
CVCL_3827 (K562/Adr)
CVCL_4T87 (K562/DNR)
CVCL_4V20 (K562/ara-C)
CVCL_4V47 (K562/G01)
CVCL_4V51 (K562/NIL-50)
CVCL_4V54 (K562-BMS-R)
CVCL_4V59 (K562-DAS[r])
CVCL_4V60 (K562-IMA[r])
CVCL_4V61 (K562-IMA[r]+DAS[r])
CVCL_4V62 (K562-IMA[r]+PON[r])
CVCL_4V63 (K562-NIL[r])
CVCL_4V64 (K562-PON[r])
CVCL_4V84 (K562/AS-3)
CVCL_4V85 (K562/AS2)
CVCL_5144 (K562/MTX-2)
CVCL_5145 (K562/Vin)
CVCL_5950 (K-562R)
CVCL_5J01 (K562-Red-FLuc)
CVCL_5J21 (K562-luc2)
CVCL_6217 (DUTKO-1)
CVCL_8423 (RS-1 [Human leukemia])
CVCL_8427 (T-33)
CVCL_8440 (SAM-1)
CVCL_8463 (RM10)
CVCL_9119 (K562(S))
CVCL_9120 (K562(A))
CVCL_9121 (K562-H)
CVCL_9122 (K562-L)
CVCL_9V30 (KDI/20)
CVCL_AW13 (K562 eGFP-ATF1)
CVCL_AW14 (K562 eGFP-BACH1)
CVCL_AW15 (K562 eGFP-CEBPB)
CVCL_AW16 (K562 eGFP-CREB3)
CVCL_AW17 (K562 eGFP-DDX20)
CVCL_AW18 (K562 eGFP-DIDO1)
CVCL_AW19 (K562 eGFP-E2F1)
CVCL_AW20 (K562 eGFP-ETV1)
CVCL_AW21 (K562 eGFP-FOS)
CVCL_AW22 (K562 eGFP-GATA2)
CVCL_AW23 (K562 eGFP-HDAC8)
CVCL_AW24 (K562 eGFP-HINFP)
CVCL_AW25 (K562 eGFP-HMGB1)
CVCL_AW26 (K562 eGFP-ID3)
CVCL_AW27 (K562 eGFP-ILK)
CVCL_AW28 (K562 eGFP-IRF1)
CVCL_AW29 (K562 eGFP-IRF9)
CVCL_AW30 (K562 eGFP-JUNB)
CVCL_AW31 (K562 eGFP-JUND)
CVCL_AW32 (K562 eGFP-KLF1)
CVCL_AW33 (K562 eGFP-KLF13)
CVCL_AW34 (K562 eGFP-MAFG)
CVCL_AW35 (K562 eGFP-NFE2L1)
CVCL_AW36 (K562 eGFP-NR2C1)
CVCL_AW37 (K562 eGFP-NR4A1)
CVCL_AW38 (K562 eGFP-PTRF)
CVCL_AW39 (K562 eGFP-PTTG1)
CVCL_AW40 (K562 eGFP-PYGO2)
CVCL_AW41 (K562 eGFP-RELA)
CVCL_AW42 (K562 eGFP-SMARCA1)
CVCL_AW43 (K562 eGFP-SMARCA2)
CVCL_AW44 (K562 eGFP-TAF7)
CVCL_AW45 (K562 eGFP-TEAD2)
CVCL_AW46 (K562 eGFP-TSC22D4)
CVCL_AW47 (K562 eGFP-ZNF24)
CVCL_AW48 (K562 eGFP-ZSCAN9)
CVCL_AZ73 (K562/CP)
CVCL_B502 (K562 BZQR)
CVCL_D162 (K562-Lucena 1)
CVCL_D201 (K562-IMR)
CVCL_D205 (K562/D1-9)
CVCL_D573 (K562/R7)
CVCL_DP55 (K562-rn)
CVCL_GZ75 (K562 eGFP-ADNP)
CVCL_GZ76 (K562 eGFP-ATF3)
CVCL_GZ77 (K562 eGFP-CEBPG)
CVCL_GZ78 (K562 eGFP-CUX1)
CVCL_GZ79 (K562 eGFP-E2F4)
CVCL_GZ80 (K562 eGFP-E2F5)
CVCL_GZ81 (K562 eGFP-ELF1)
CVCL_GZ82 (K562 eGFP-ELK1)
CVCL_GZ83 (K562 eGFP-ETS2)
CVCL_GZ84 (K562 eGFP-FOSL1)
CVCL_GZ85 (K562 eGFP-FOXJ2)
CVCL_GZ86 (K562 eGFP-GABPA)
CVCL_GZ87 (K562 eGFP-GTF2A2)
CVCL_GZ88 (K562 eGFP-GTF2E2)
CVCL_GZ89 (K562 eGFP-MEF2D)
CVCL_GZ90 (K562 eGFP-NFE2)
CVCL_GZ91 (K562 eGFP-NR2C2)
CVCL_GZ92 (K562 eGFP-PBX2)
CVCL_GZ93 (K562 eGFP-POLR2H)
CVCL_GZ94 (K562 eGFP-TFDP1)
CVCL_GZ95 (K562 eGFP-USF2)
CVCL_GZ96 (K562 eGFP-ZBTB11)
CVCL_GZ97 (K562 eGFP-ZFX)
CVCL_GZ98 (K562 eGFP-ZKSCAN8)
CVCL_GZ99 (K562 eGFP-ZNF148)
CVCL_HA00 (K562 eGFP-ZNF175)
CVCL_HA01 (K562 eGFP-ZNF197)
CVCL_HA02 (K562 eGFP-ZNF395)
CVCL_HA03 (K562 eGFP-ZNF512)
CVCL_HA04 (K562 eGFP-ZNF584)
CVCL_HA05 (K562 eGFP-ZNF589)
CVCL_HA06 (K562 eGFP-ZNF639)
CVCL_HA07 (K562 eGFP-ZNF644)
CVCL_HA08 (K562 eGFP-ZNF740)
CVCL_HA09 (K562 eGFP-ZNF766)
CVCL_HA10 (K562 eGFP-ZNF83)
CVCL_IM25 (K562 HHT)
CVCL_IQ44 (NM-D4)
CVCL_IQ45 (NM-F9)
CVCL_J257 (K562-Luc)
CVCL_J651 (DD)
CVCL_JM00 (K-562-GFP)
CVCL_JX91 (K562-AVB3)
CVCL_KS44 (K562/NFAT-luc)
CVCL_L434 (P2UR/K-562)
CVCL_L806 (TI-1 [Human leukemia])
CVCL_LH50 (K-562-RH)
CVCL_LH51 (K-562-C-1 p365)
CVCL_LH52 (K-562-B1-V-2 p17)
CVCL_RY26 (K-562 CRISPRa)
CVCL_S029 (K-562 SimpleCell O-GalNAc)
CVCL_S663 (K562/ZD1694.C)
CVCL_UC14 (K562-r)
CVCL_UC15 (K562-s)
CVCL_UR39 (K-562-luc2)
CVCL_WI19 (K562/DAC)
CVCL_WU73 (HL-CZ)
CVCL_XE50 (K562-Wnt5a)
CVCL_XW96 (K562 eGFP-ZNF354B)
CVCL_XW97 (K562 eGFP-ZNF507)
CVCL_Y168 (K562/etop20)
CVCL_Y169 (K562/etop80)
CVCL_Y198 (K562/AC)
CVCL_Z732 (K562-ARA-C)
CVCL_Z733 (K562-CdA)
CVCL_Z734 (K562-FLUD)
CVCL_Z735 (K562-GEM)
CVCL_ZL53 (K562 NGLY1 KO c15)
CVCL_ZL54 (K562 NGLY1 KO c20)
Aliases: GM05372; GM05372E; K 562; K-652; K.562; K562; K652; KO
Disease(s): chronic myeloid leukemia (DOID:8552) [NCI:C3174,ORDO:521]


References

References - uncurated

Additional Information

External Database Links
 
RGD Object Information
RGD ID: 21113446
Created: 2020-02-27
Species: Homo sapiens
Last Modified: 2020-02-27
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.