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Cell Line : CVCL_0002 (HL-60) Homo sapiens

Symbol: CVCL_0002
Name: HL-60
Cell Line Type: cancer cell line
Origin: Derived from sampling site: Peripheral blood.
Gender: Female
Research Use: Biotechnology: Used a source of mitochondrial DNA for USA forensic testing; Omics: Array-based CGH; Omics: Cell surface proteome; Omics: CNV analysis; Omics: Deep antibody staining analysis; Omics: Deep exome analysis; Omics: Deep RNAseq analysis; Omics: DNA methylation analysis; Omics: H3K4me3 ChIP-seq epigenome analysis; Omics: Mitochondrial genome sequenced; Omics: N-glycan profiling; Omics: Protein expression by reverse-phase protein arrays; Omics: shRNA library screening; Omics: SNP array analysis; Omics: Transcriptome analysis
Availability: Discontinued: JCRB; NIHS0086; true
Phenotype: Doubling time: 16 hours (PubMed=8343448); 28 hours (PubMed=25984343); ~40 hours (DSMZ); Microsatellite instability: Stable (MSS) (PubMed=12661003; Sanger)
Genomic Alteration: Sequence variation: Homozygous for CDKN2A p.Arg80Ter (c.238C>T) (p.Pro94Leu; c.281C>T) (PubMed=17088437); Sequence variation: Heterozygous for NRAS p.Gln61Leu (c.182A>T) (ClinVar=VCV000375874) (PubMed=12068308; PubMed=17088437); Sequence variation: Homozygous for TP53 deletion (PubMed=2858093)
Groups: Group: Space-flown cell line (cellonaut); Part of: Cancer Cell Line Encyclopedia (CCLE) project; Part of: COSMIC cell lines project; Part of: ENCODE project common cell types; tier 3; Part of: LL-100 blood cancer cell line panel; Part of: MD Anderson Cell Lines Project; Part of: MYC genetic alteration cell panel (ATCC TCP-1035); Registration: National Institute of Standards and Technology, Standard Reference Materials; SRM 2392-I
Description: Genome ancestry: African=1.15%; Native American=0.42%; East Asian, North=0.4%; East Asian, South=0%; South Asian=0%; European, North=71.71%; European, South=26.32% (PubMed=30894373)
Child Cell Lines: CVCL_0304 (HL-60/ADR)
CVCL_0305 (HL-60/VCR)
CVCL_0478 (P39)
CVCL_2162 (PLB-985)
CVCL_2493 (HL-60 clone 15)
CVCL_2495 (HL60 Ast.3)
CVCL_2496 (HL60 Ast.4)
CVCL_2497 (HL60 M2)
CVCL_2498 (HL60 M4)
CVCL_2892 (Eos-HL-60)
CVCL_2944 (HL60(S))
CVCL_2945 (HL60RG)
CVCL_3332 (HL-60/MX1)
CVCL_4458 (HL-60/DNR)
CVCL_4635 (HL-60-R2)
CVCL_4967 (HL-60/Vinc)
CVCL_4V19 (HL-60/ara-C [Japan 2011])
CVCL_4V55 (HL/CAFdA20)
CVCL_8439 (HIMeg-1)
CVCL_8710 (HP100-1)
CVCL_8711 (HP50-2)
CVCL_8907 (RED-3)
CVCL_8931 (YJ)
CVCL_A794 (HL-60(TB))
CVCL_AR85 (HL60 Ast.25)
CVCL_AR88 (HL60 Ast.1)
CVCL_AR89 (HL60 Sp1)
CVCL_D567 (OM10.1)
CVCL_II77 (HL-60/S4)
CVCL_II78 (HL-60/R3)
CVCL_J128 (VXG3)
CVCL_RS49 (HL-60rARA-C2mug/ML)
CVCL_UM46 (HL-60 248)
CVCL_UM47 (HL-60 SCX3)
CVCL_UM48 (HL-60 SN3)
CVCL_VK43 (HL-60 blast)
CVCL_WR44 (HL-60/AR)
CVCL_WW75 (HL-60-Y3)
CVCL_WZ17 (HL-60 DeltaF508-CF)
CVCL_XE38 (HL-60/RS)
CVCL_YN03 (NDi001-A)
CVCL_YP33 (HL-60/5FU)
CVCL_YT56 (HL-60R)
CVCL_Z938 (HL-60/ara-C [USA 1984])
Aliases: HL 60; HL.60 HL60; HL60; IIL-60


References - uncurated

Additional Information

External Database Links
RGD Object Information
RGD ID: 21113444
Created: 2020-02-27
Species: Homo sapiens
Last Modified: 2020-02-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.