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Cell Line : CVCL_0025 (Caco-2) Homo sapiens

Symbol: CVCL_0025
Name: Caco-2
Cell Line Type: cancer cell line
Gender: Male
Research Use: Omics: Deep antibody staining analysis; Omics: Deep exome analysis; Omics: Deep phosphoproteome analysis; Omics: Deep proteome analysis; Omics: Deep RNAseq analysis; Omics: H3K4me3 ChIP-seq epigenome analysis; Omics: H3K27me3 ChIP-seq epigenome analysis; Omics: H3K36me3 ChIP-seq epigenome analysis; Omics: miRNA expression profiling; Omics: N-glycan profiling; Omics: Protein expression by reverse-phase protein arrays; Omics: SNP array analysis; Omics: Transcriptome analysis
Characteristics: Characteristics: Highly permissive to SARS coronavirus (SARS-Cov) infection (PubMed=15316659)
Phenotype: Doubling time: ~80 hours (DSMZ); ~32 hours (PBCF); ~60-70 hours (CLS); Microsatellite instability: Stable (MSS) (PubMed=24042735; PubMed=25926053; PubMed=28683746)
Genomic Alteration: Sequence variation: Homozygous for APC p.Gln1367Ter (c.4099C>T) (PubMed=24755471; CCLE); Sequence variation: Heterozygous for CTNNB1 p.Gly245Ala (c.734G>C) (PubMed=9294210); Sequence variation: Homozygous for SMAD4 p.Asp351His (c.1051G>C) (PubMed=24755471; CCLE); Sequence variation: Homozygous for TP53 p.Glu204Ter (c.610G>T) (PubMed=16418264; PubMed=24755471; PubMed=28683746; CCLE)
Groups: Part of: AstraZeneca Colorectal cell line (AZCL) panel; Part of: Cancer Cell Line Encyclopedia (CCLE) project; Part of: ENCODE project common cell types; tier 3; Part of: MD Anderson Cell Lines Project
Description: HLA typing: A*02:01,02:01; B*15:05,56/39; C*04:01,04:01 (PubMed=25960936); Genome ancestry: African=3.33%; Native American=0%; East Asian, North=4.59%; East Asian, South=0%; South Asian=0%; European, North=47.35%; European, South=44.73% (PubMed=30894373).
Child Cell Lines: CVCL_0232 (Caco-2/15)
CVCL_0233 (Caco-2/TC-7)
CVCL_1096 (C2BBe1)
CVCL_HA82 (Caco-2-RCAr clone 2)
CVCL_YP11 (Caco-2 Cu Pro-R)
CVCL_YP12 (Caco-2 CuSO4-R)
CVCL_Z578 (Caco-2/3)
CVCL_Z579 (Caco-2/PD-10)
CVCL_Z580 (Caco-2/PD-7)
CVCL_Z581 (Caco-2/PF-11)
CVCL_Z582 (C2BBe2)
Aliases: Caco 2; CaCo-2; Caco-2/ATCC; Caco-II; CACO2
Disease(s): colon adenocarcinoma (DOID:234) [NCI:C4349]


References

References - uncurated

Additional Information

External Database Links
 
RGD Object Information
RGD ID: 21113383
Created: 2020-02-27
Species: Homo sapiens
Last Modified: 2020-02-27
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.