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Cell Line : CVCL_0021 (U-251MG) Homo sapiens

Symbol: CVCL_0021
Name: U-251MG
Cell Line Type: cancer cell line
Gender: Male
Research Use: Omics: Array-based CGH; Omics: Cell surface proteome; Omics: CNV analysis; Omics: Deep antibody staining analysis; Omics: Deep exome analysis; Omics: Deep proteome analysis; Omics: Deep RNAseq analysis; Omics: DNA methylation analysis; Omics: Fluorescence phenotype profiling; Omics: lncRNA expression profiling; Omics: Metabolome analysis; Omics: Protein expression by reverse-phase protein arrays; Omics: shRNA library screening; Omics: SNP array analysis; Omics: Transcriptome analysis
Availability: Discontinued: RCB; RCB0461; true.
Phenotype: Doubling time: 24 hours (PubMed=25984343); 23.8 hours (NCI-DTP); Microsatellite instability: Stable (MSS) (Sanger)
Genomic Alteration: Sequence variation: Has no IDH1 mutation (PubMed=19435942); Sequence variation: PTEN p.Glu242fs*15 (c.723_724insTT) (PubMed=9090379; PubMed=10551321; PubMed=10560660); Sequence variation: TERT c.228C>T (-124C>T); in promoter (PubMed=31068700); Sequence variation: Homozygous for TP53 p.Arg273His (c.818G>A) (ClinVar=VCV000012366) (PubMed=8878451; PubMed=9614553; PubMed=10416987; PubMed=14614447; PubMed=15900046)
Groups: Part of: Cancer Cell Line Encyclopedia (CCLE) project; Part of: COSMIC cell lines project; Part of: JFCR39 cancer cell line panel; Part of: MD Anderson Cell Lines Project; Part of: NCI-60 cancer cell line panel
Description: HLA typing: A*02:01:01; B*18; C*05; DPB1*04:02; DQB1*02:01; DRB1*03:01:01 (PubMed=15748285); HLA typing: A*02:01,02:01; B*18:01,18:01; C*05:01,05:01 (PubMed=25960936); Genome ancestry: African=0.69%; Native American=0%; East Asian, North=2.21%; East Asian, South=0%; South Asian=0%; European, North=79.45%; European, South=17.65% (PubMed=30894373)
Child Cell Lines: CVCL_0535 (SNB-19)
CVCL_1G29 (U251-TR3)
CVCL_2219 (U-373MG ATCC)
CVCL_2800 (KNS-89)
CVCL_2809 (U-251MG (KO))
CVCL_2864 (B2-17)
CVCL_5G56 (U-251MG sp)
CVCL_5G63 (U-251MG AgCl1)
CVCL_B325 (TK-1 [Human astrocytoma])
CVCL_J269 (U-251MG-Luc)
Aliases: 251 MG; 251MG; U-251; U-251 MG; U-251-MG; U-251_MG; U251; U251-MG; U251MG; U251n
Disease(s): astrocytoma (DOID:3069) [NCI:C60781]
autosomal dominant cerebellar ataxia (DOID:1441) [ORDO:94]


References

References - uncurated

Additional Information

External Database Links
 
RGD Object Information
RGD ID: 21113379
Created: 2020-02-27
Species: Homo sapiens
Last Modified: 2020-02-27
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.