Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

Cell Line : CVCL_0022 (U-87MG ATCC) Homo sapiens

Symbol: CVCL_0022
Name: U-87MG ATCC
Cell Line Type: cancer cell line
Gender: Male
Research Use: Omics: Cell surface proteome; Omics: CNV analysis; Omics: Deep antibody staining analysis; Omics: Deep exome analysis; Omics: Deep proteome analysis; Omics: Deep quantitative proteome analysis; Omics: Deep RNAseq analysis; Omics: DNA methylation analysis; Omics: Genome sequenced; Omics: HLA class I peptidome analysis by proteomics; Omics: shRNA library screening; Omics: SNP array analysis; Omics: Transcriptome analysis
Availability: Discontinued: RCB; RCB0419; true.
Phenotype: Doubling time: 72 hours (PubMed=25984343); ~34 hours (PBCF); Microsatellite instability: Stable (MSS) (Sanger)
Genomic Alteration: Sequence variation: Has no IDH1 mutation (PubMed=19435942); Sequence variation: Heterozygous for NF1 p.Phe1247fs*18 (c.3737_3740delTGTT) (CCLE; Cosmic-CLP); Sequence variation: Homozygous for PTEN c.209+1G>T; splice donor mutation (PubMed=9090379; CCLE; Cosmic-CLP); Sequence variation: TERT c.228C>T (-124C>T); in promoter (PubMed=31068700); Sequence variation: Has no TP53 mutation (CCLE; Cosmic-CLP)
Caution: Problematic cell line: Misidentified This cell line is not the original glioblastoma cell line established in 1968 at the University of Uppsala. As described in PubMed=27582061 it is most probably also a glioblastoma cell line but whose origin is unknow. See U-87MG Uppsala (CVCL_GP63) for the original U-87MG cell line.
Groups: Part of: Cancer Cell Line Encyclopedia (CCLE) project; Part of: COSMIC cell lines project; Part of: ENCODE project common cell types; tier 3; Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00535
Description: HLA typing: A*02:01,02:01; B*44:02,44:02; C*05:01,05:01; DQA1*01:02,01:02; DQB1*06:02,06:02; DRB1*15:01,13:07 (PubMed=25960936); HLA typing: A*02:01:01; B*44:02; C*05:01:01 (PubMed=27412690); Genome ancestry: African=0.69%; Native American=0%; East Asian, North=3.92%; East Asian, South=0%; South Asian=0%; European, North=72.18%; European, South=23.21% (PubMed=30894373)
Child Cell Lines: CVCL_3428 (U87/DK)
CVCL_3429 (U87/WT)
CVCL_4V16 (U87-MG/Pt)
CVCL_5J12 (U87 MG-Red-FLuc)
CVCL_5J15 (U-87 MG-luc2)
CVCL_JY78 (U87MG.deltaEGFR)
CVCL_UE09 (U-87MG ATCC IDH1 p.R132H)
CVCL_UR33 (U-87 MG-Luc2)
CVCL_X626 (U87.CD4)
CVCL_X702 (U87-CD4 Clone 2)
Aliases: 87 MG; 87MG; U-87; U-87 MG; U-87-MG; U-87MG; U87; U87 MG; U87-MG; U87MG
Disease(s): glioblastoma multiforme (DOID:3068) [NCI:C3058]


References - uncurated

Additional Information

External Database Links
RGD Object Information
RGD ID: 21113378
Created: 2020-02-27
Species: Homo sapiens
Last Modified: 2020-02-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.