Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1307069
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abca8
Name: ATP binding cassette subfamily A member 8
Acc ID: CHEBI:9948
Term: verapamil
Definition: A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
Chemical ID: MESH:D014700
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abca8multiple interactionsISOABCA8 (Homo sapiens)6480464CTDVerapamil inhibits the reaction [ABCA8 protein results in increased uptake of estradiol-17 beta-glucuronide]PMID:12379217
Go Back to source page   Continue to Ontology report