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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3401
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Prkg2
Name: protein kinase cGMP-dependent 2
Acc ID: CHEBI:9763
Term: trovafloxacin
Definition: A 1,8-naphthyridine derivative that is 4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid bearing additional 2,4-difluorophenyl, fluoro and 6-amino-3-azabicyclo[3.1.0]hex-3-yl substituents at positions 1, 6 and 7 respectively. A broad-spectrum antibiotic that was withdrawn from the market due to risk of liver failure.
Chemical ID: MESH:C080163
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Prkg2decreases expressionISOPrkg2 (Mus musculus)6480464CTDtrovafloxacin results in decreased expression of PRKG2 mRNAPMID:35537566
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