GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Eif2ak3 | multiple interactions | ISO | EIF2AK3 (Homo sapiens) | 156430337 | RGD | glucose promotes the reaction [thapsigargin increases phosphorylation of Eif2ak3 protein in cardiac muscle cells] | | Eif2ak3 | increases phosphorylation | EXP | | 6480464 | CTD | Thapsigargin results in increased phosphorylation of EIF2AK3 protein | PMID:23576437 PMID:24150608 | Eif2ak3 | increases response to substance | EXP | | 6480464 | CTD | EIF2AK3 gene mutant form results in increased susceptibility to Thapsigargin | PMID:17283163 | Eif2ak3 | multiple interactions | EXP | | 6480464 | CTD | 1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea inhibits the reaction [Thapsigargin results in increased phosphorylation of EIF2AK3 protein]; [Thapsigargin co-treated with HRAS protein] results in increased expression of EIF2AK3 protein; EIF2AK3 gene mutant form inhibits the reaction [Thapsigargin results in increased expression of IBTK mRNA alternative form]; PTPN1 gene mutant form promotes the reaction [Thapsigargin results in increased activity of and results in increased phosphorylation of EIF2AK3 protein]; Thapsigargin promotes the reaction [EIF2AK3 protein results in increased phosphorylation of EIF2A protein]; Thapsigargin results in increased activity of and results in increased phosphorylation of EIF2AK3 protein | PMID:17283163 PMID:22509299 PMID:23576437 PMID:24648495 PMID:24898257 | Eif2ak3 | increases acetylation | ISO | Eif2ak3 (Rattus norvegicus) | 6480464 | CTD | Thapsigargin results in increased acetylation of EIF2AK3 protein | PMID:29653943 | Eif2ak3 | increases expression | ISO | EIF2AK3 (Homo sapiens) | 6480464 | CTD | Thapsigargin results in increased expression of EIF2AK3 mRNA; Thapsigargin results in increased expression of EIF2AK3 protein; Thapsigargin results in increased expression of EIF2AK3 protein modified form | PMID:17963750 PMID:22378314 PMID:24224909 PMID:24865413 PMID:30796460 | Eif2ak3 | increases phosphorylation | ISO | EIF2AK3 (Homo sapiens) | 6480464 | CTD | Thapsigargin results in increased phosphorylation of EIF2AK3 protein | PMID:23576437 PMID:23741617 PMID:26264395 | Eif2ak3 | increases phosphorylation | ISO | Eif2ak3 (Rattus norvegicus) | 6480464 | CTD | Thapsigargin results in increased phosphorylation of EIF2AK3 protein | PMID:29653943 PMID:35028790 | Eif2ak3 | multiple interactions | ISO | EIF2AK3 (Homo sapiens) | 6480464 | CTD | 1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea inhibits the reaction [Thapsigargin results in increased phosphorylation of EIF2AK3 protein]; 2-(4-chlorophenoxy)-N-(4-(2-(4-chlorophenoxy)acetamido)cyclohexyl)acetamide promotes the reaction [Thapsigargin results in increased phosphorylation of EIF2AK3 protein]; demethoxycurcumin analog inhibits the reaction [Thapsigargin results in increased phosphorylation of EIF2AK3 protein]; EIF2AK3 mutant form inhibits the reaction [Thapsigargin results in increased phosphorylation of EIF2S1 protein]; EIF2AK3 promotes the reaction [Thapsigargin results in increased expression of DDIT3 protein]; EIF2AK3 promotes the reaction [Thapsigargin results in increased expression of HSPA5 protein]; Thapsigargin promotes the reaction [pterostilbene results in increased phosphorylation of EIF2AK3 protein] | PMID:20022965 PMID:23576437 PMID:23741617 PMID:25341683 PMID:26264395 PMID:27358234 | Eif2ak3 | multiple interactions | ISO | Eif2ak3 (Rattus norvegicus) | 6480464 | CTD | EIF2AK3 gene mutant form inhibits the reaction [Thapsigargin results in increased phosphorylation of EIF2S1 protein]; shikonin inhibits the reaction [Thapsigargin results in increased phosphorylation of EIF2AK3 protein]; Thapsigargin inhibits the reaction [dapagliflozin inhibits the reaction [IL1B protein results in increased expression of EIF2AK3 mRNA]] | PMID:16324875 PMID:35028790 PMID:37741535 | |
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