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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62396
Species: Mus musculus
RGD Object: Gene
Symbol: Ddit3
Name: DNA-damage inducible transcript 3
Acc ID: CHEBI:9516
Term: thapsigargin
Definition: An organic heterotricyclic compound that is a hexa-oxygenated 6,7-guaianolide isolated fron the roots of Thapsia garganica L., Apiaceae. A potent skin irritant, it is used in traditional medicine as a counter-irritant. Thapsigargin inhibits Ca(2+)-transporting ATPase mediated uptake of calcium ions into sarcoplasmic reticulum and is used in experimentation examining the impacts of increasing cytosolic calcium concentrations.
Chemical ID: MESH:D019284
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ddit3multiple interactionsEXP 156430337RGDthapsigargin promotes the reaction [glucose increases expression of Ddit3 protein in cardiac muscle cell] 
Ddit3increases expressionEXP 6480464CTDThapsigargin results in increased expression of DDIT3 mRNA; Thapsigargin results in increased expression of DDIT3 proteinPMID:16330322 PMID:17475668 PMID:20493918 PMID:20589738 PMID:22509299 PMID:24648495 PMID:25324550 PMID:27226639 PMID:28223344 PMID:28942281 PMID:29109149 PMID:30508555 PMID:32407927 PMID:32578922
Ddit3multiple interactionsEXP 6480464CTD2-aminoethoxydiphenyl borate inhibits the reaction [Thapsigargin results in increased expression of DDIT3 mRNA]; 7-methyl-5-(1-((3-(trifluoromethyl)phenyl)acetyl)-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo(2,3-d)pyrimidin-4-amine inhibits the reaction [Thapsigargin results in increased expression of DDIT3 protein]; Acetylcysteine inhibits the reaction [Thapsigargin results in increased expression of DDIT3 protein]; Apigenin inhibits the reaction [Thapsigargin results in increased expression of DDIT3 protein]; EIF2S1 protein modified form affects the reaction [Thapsigargin results in increased expression of DDIT3 mRNA]; EIF2S1 protein modified form affects the reaction [Thapsigargin results in increased expression of DDIT3 protein]; Glutathione inhibits the reaction [Thapsigargin results in increased expression of DDIT3 protein]; Luteolin inhibits the reaction [Thapsigargin results in increased expression of DDIT3 protein]; PTPN1 gene mutant form promotes the reaction [Thapsigargin results in increased expression of DDIT3 mRNA]; PTPN1 gene mutant form promotes the reaction [Thapsigargin results in increased expression of DDIT3 protein]; salubrinal inhibits the reaction [Thapsigargin results in increased expression of DDIT3 protein]; Thapsigargin inhibits the reaction [7,14-dihydroxydocosa-4,8,10,12,16,19-hexaenoic acid inhibits the reaction [Palmitic Acid results in increased expression of DDIT3 protein]]; Thapsigargin promotes the reaction [Arsenic Trioxide results in increased expression of DDIT3 protein]; Vaticanol B inhibits the reaction [Thapsigargin results in increased expression of DDIT3 protein]PMID:17475668 PMID:20493918 PMID:22509299 PMID:27638049 PMID:29109149 PMID:29414781 PMID:30508555 PMID:32407927 PMID:32578922
Ddit3decreases response to substanceISODDIT3 (Homo sapiens)6480464CTDDDIT3 results in decreased susceptibility to ThapsigarginPMID:20022965
Ddit3increases activityISODDIT3 (Homo sapiens)6480464CTDThapsigargin results in increased activity of DDIT3 proteinPMID:19139269
Ddit3increases expressionISODdit3 (Rattus norvegicus)6480464CTDThapsigargin results in increased expression of DDIT3 mRNA; Thapsigargin results in increased expression of DDIT3 proteinPMID:16338971 PMID:19028522 PMID:19285962 PMID:22641616 PMID:23123503 PMID:24668805 PMID:28315715 PMID:28844859 PMID:32574669 PMID:35033536 PMID:35544339
Ddit3increases expressionISODDIT3 (Homo sapiens)6480464CTDThapsigargin results in increased expression of DDIT3 mRNA; Thapsigargin results in increased expression of DDIT3 proteinPMID:16298333 PMID:17283163 PMID:17332266 PMID:17353921 PMID:19135031 PMID:19428936 PMID:20626587 PMID:21525004 PMID:21694771 PMID:22378314 PMID:22800509 PMID:22843330 PMID:22935518 PMID:23123503 PMID:24865413 PMID:25289770 PMID:26264395 PMID:26513129 PMID:27358234 PMID:27587023 PMID:28940366 PMID:29453283 PMID:32407927 PMID:32535746 PMID:34915026
Ddit3multiple interactionsISODdit3 (Rattus norvegicus)6480464CTD1-Deoxynojirimycin inhibits the reaction [Thapsigargin results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [Thapsigargin results in increased expression of DDIT3 protein]; GW 506033X inhibits the reaction [Thapsigargin results in increased expression of DDIT3 mRNA]; salubrinal promotes the reaction [Thapsigargin results in increased expression of DDIT3 protein]; Thapsigargin results in increased expression of and affects the localization of DDIT3 proteinPMID:19028522 PMID:24668805 PMID:28844859 PMID:32574669
Ddit3multiple interactionsISODDIT3 (Homo sapiens)6480464CTDATF6 promotes the reaction [Thapsigargin results in increased expression of DDIT3 protein]; demethoxycurcumin analog inhibits the reaction [Thapsigargin results in increased expression of DDIT3 protein]; Doxorubicin inhibits the reaction [Thapsigargin results in increased expression of DDIT3 protein]; EIF2AK3 promotes the reaction [Thapsigargin results in increased expression of DDIT3 protein]; Luteolin inhibits the reaction [Thapsigargin results in increased expression of DDIT3 mRNA]; Luteolin inhibits the reaction [Thapsigargin results in increased expression of DDIT3 protein]; Quercetin inhibits the reaction [Thapsigargin results in increased expression of DDIT3 mRNA]; Thapsigargin promotes the reaction [DDIT3 protein binds to LCN2 promoter]; Thapsigargin promotes the reaction [pterostilbene results in increased expression of DDIT3 protein]; Thapsigargin results in increased expression of and affects the localization of DDIT3 proteinPMID:16298333 PMID:19428936 PMID:22800509 PMID:25341683 PMID:26264395 PMID:27358234 PMID:32407927 PMID:35033536
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