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REFERENCE - CHEMICAL INTERACTIONS REPORT

RGD ID: 156430337
Species: All species
RGD Object: Reference
Acc ID: CHEBI:9516
Term: thapsigargin
Definition: An organic heterotricyclic compound that is a hexa-oxygenated 6,7-guaianolide isolated fron the roots of Thapsia garganica L., Apiaceae. A potent skin irritant, it is used in traditional medicine as a counter-irritant. Thapsigargin inhibits Ca(2+)-transporting ATPase mediated uptake of calcium ions into sarcoplasmic reticulum and is used in experimentation examining the impacts of increasing cytosolic calcium concentrations.
Chemical ID: MESH:D019284
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
EIF2AK3multiple interactionsEXP 156430337RGDglucose promotes the reaction [thapsigargin increases phosphorylation of Eif2ak3 protein in cardiac muscle cells] 
Ddit3multiple interactionsEXP 156430337RGDthapsigargin promotes the reaction [glucose increases expression of Ddit3 protein in cardiac muscle cell] 
Eif2ak3multiple interactionsISOEIF2AK3 (Homo sapiens)156430337RGDglucose promotes the reaction [thapsigargin increases phosphorylation of Eif2ak3 protein in cardiac muscle cells] 
DDIT3multiple interactionsISODdit3 (Mus musculus)156430337RGDthapsigargin promotes the reaction [glucose increases expression of Ddit3 protein in cardiac muscle cell] 
Ddit3multiple interactionsISODdit3 (Mus musculus)156430337RGDthapsigargin promotes the reaction [glucose increases expression of Ddit3 protein in cardiac muscle cell] 
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