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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1354090
Species: Homo sapiens
RGD Object: Gene
Symbol: EIF2AK3
Name: eukaryotic translation initiation factor 2 alpha kinase 3
Acc ID: CHEBI:9516
Term: thapsigargin
Definition: An organic heterotricyclic compound that is a hexa-oxygenated 6,7-guaianolide isolated fron the roots of Thapsia garganica L., Apiaceae. A potent skin irritant, it is used in traditional medicine as a counter-irritant. Thapsigargin inhibits Ca(2+)-transporting ATPase mediated uptake of calcium ions into sarcoplasmic reticulum and is used in experimentation examining the impacts of increasing cytosolic calcium concentrations.
Chemical ID: MESH:D019284
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
EIF2AK3multiple interactionsEXP 156430337RGDglucose promotes the reaction [thapsigargin increases phosphorylation of Eif2ak3 protein in cardiac muscle cells] 
EIF2AK3increases expressionEXP 6480464CTDThapsigargin results in increased expression of EIF2AK3 mRNA; Thapsigargin results in increased expression of EIF2AK3 protein; Thapsigargin results in increased expression of EIF2AK3 protein modified formPMID:17963750 PMID:22378314 PMID:24224909 PMID:24865413 PMID:30796460
EIF2AK3increases phosphorylationEXP 6480464CTDThapsigargin results in increased phosphorylation of EIF2AK3 proteinPMID:23576437 PMID:23741617 PMID:26264395
EIF2AK3multiple interactionsEXP 6480464CTD1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea inhibits the reaction [Thapsigargin results in increased phosphorylation of EIF2AK3 protein]; 2-(4-chlorophenoxy)-N-(4-(2-(4-chlorophenoxy)acetamido)cyclohexyl)acetamide promotes the reaction [Thapsigargin results in increased phosphorylation of EIF2AK3 protein]; demethoxycurcumin analog inhibits the reaction [Thapsigargin results in increased phosphorylation of EIF2AK3 protein]; EIF2AK3 mutant form inhibits the reaction [Thapsigargin results in increased phosphorylation of EIF2S1 protein]; EIF2AK3 promotes the reaction [Thapsigargin results in increased expression of DDIT3 protein]; EIF2AK3 promotes the reaction [Thapsigargin results in increased expression of HSPA5 protein]; Thapsigargin promotes the reaction [pterostilbene results in increased phosphorylation of EIF2AK3 protein]PMID:20022965 PMID:23576437 PMID:23741617 PMID:25341683 PMID:26264395 PMID:27358234
EIF2AK3increases acetylationISOEif2ak3 (Rattus norvegicus)6480464CTDThapsigargin results in increased acetylation of EIF2AK3 proteinPMID:29653943
EIF2AK3increases phosphorylationISOEif2ak3 (Rattus norvegicus)6480464CTDThapsigargin results in increased phosphorylation of EIF2AK3 proteinPMID:29653943 PMID:35028790
EIF2AK3increases phosphorylationISOEif2ak3 (Mus musculus)6480464CTDThapsigargin results in increased phosphorylation of EIF2AK3 proteinPMID:23576437 PMID:24150608
EIF2AK3increases response to substanceISOEif2ak3 (Mus musculus)6480464CTDEIF2AK3 gene mutant form results in increased susceptibility to ThapsigarginPMID:17283163
EIF2AK3multiple interactionsISOEif2ak3 (Rattus norvegicus)6480464CTDEIF2AK3 gene mutant form inhibits the reaction [Thapsigargin results in increased phosphorylation of EIF2S1 protein]; shikonin inhibits the reaction [Thapsigargin results in increased phosphorylation of EIF2AK3 protein]; Thapsigargin inhibits the reaction [dapagliflozin inhibits the reaction [IL1B protein results in increased expression of EIF2AK3 mRNA]]PMID:16324875 PMID:35028790 PMID:37741535
EIF2AK3multiple interactionsISOEif2ak3 (Mus musculus)6480464CTD1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea inhibits the reaction [Thapsigargin results in increased phosphorylation of EIF2AK3 protein]; [Thapsigargin co-treated with HRAS protein] results in increased expression of EIF2AK3 protein; EIF2AK3 gene mutant form inhibits the reaction [Thapsigargin results in increased expression of IBTK mRNA alternative form]; PTPN1 gene mutant form promotes the reaction [Thapsigargin results in increased activity of and results in increased phosphorylation of EIF2AK3 protein]; Thapsigargin promotes the reaction [EIF2AK3 protein results in increased phosphorylation of EIF2A protein]; Thapsigargin results in increased activity of and results in increased phosphorylation of EIF2AK3 proteinPMID:17283163 PMID:22509299 PMID:23576437 PMID:24648495 PMID:24898257
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