An organic heterotricyclic compound that is a hexa-oxygenated 6,7-guaianolide isolated fron the roots of Thapsia garganica L., Apiaceae. A potent skin irritant, it is used in traditional medicine as a counter-irritant. Thapsigargin inhibits Ca(2+)-transporting ATPase mediated uptake of calcium ions into sarcoplasmic reticulum and is used in experimentation examining the impacts of increasing cytosolic calcium concentrations.
Chemical ID:
MESH:D019284
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Thapsigargin results in increased expression of EIF2AK3 mRNA; Thapsigargin results in increased expression of EIF2AK3 protein; Thapsigargin results in increased expression of EIF2AK3 protein modified form
1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea inhibits the reaction [Thapsigargin results in increased phosphorylation of EIF2AK3 protein]; 2-(4-chlorophenoxy)-N-(4-(2-(4-chlorophenoxy)acetamido)cyclohexyl)acetamide promotes the reaction [Thapsigargin results in increased phosphorylation of EIF2AK3 protein]; demethoxycurcumin analog inhibits the reaction [Thapsigargin results in increased phosphorylation of EIF2AK3 protein]; EIF2AK3 mutant form inhibits the reaction [Thapsigargin results in increased phosphorylation of EIF2S1 protein]; EIF2AK3 promotes the reaction [Thapsigargin results in increased expression of DDIT3 protein]; EIF2AK3 promotes the reaction [Thapsigargin results in increased expression of HSPA5 protein]; Thapsigargin promotes the reaction [pterostilbene results in increased phosphorylation of EIF2AK3 protein]
EIF2AK3 gene mutant form inhibits the reaction [Thapsigargin results in increased phosphorylation of EIF2S1 protein]; shikonin inhibits the reaction [Thapsigargin results in increased phosphorylation of EIF2AK3 protein]; Thapsigargin inhibits the reaction [dapagliflozin inhibits the reaction [IL1B protein results in increased expression of EIF2AK3 mRNA]]
1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea inhibits the reaction [Thapsigargin results in increased phosphorylation of EIF2AK3 protein]; [Thapsigargin co-treated with HRAS protein] results in increased expression of EIF2AK3 protein; EIF2AK3 gene mutant form inhibits the reaction [Thapsigargin results in increased expression of IBTK mRNA alternative form]; PTPN1 gene mutant form promotes the reaction [Thapsigargin results in increased activity of and results in increased phosphorylation of EIF2AK3 protein]; Thapsigargin promotes the reaction [EIF2AK3 protein results in increased phosphorylation of EIF2A protein]; Thapsigargin results in increased activity of and results in increased phosphorylation of EIF2AK3 protein