GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | AKT1 | decreases expression | ISO | Akt1 (Rattus norvegicus) | 14401598 | RGD | Streptozotocin decreases expression of Akt1 protein in the liver | | AKT1 | increases phosphorylation | ISO | Akt1 (Mus musculus) | 156430337 | RGD | streptozocin increases phosphorylation of Akt1 protein in heart | | AKT1 | multiple interactions | ISO | Akt1 (Rattus norvegicus) | 408346751 | RGD | Streptozocin decreases phosphorylation of Akt1 protein in the liver | | AKT1 | decreases expression | ISO | Akt1 (Rattus norvegicus) | 6480464 | CTD | Streptozocin results in decreased expression of AKT1 mRNA; Streptozocin results in decreased expression of AKT1 protein | PMID:26071184 PMID:26286522 PMID:27417257 PMID:32805344 PMID:33724628 PMID:35414346 | AKT1 | decreases phosphorylation | ISO | Akt1 (Rattus norvegicus) | 6480464 | CTD | Streptozocin results in decreased phosphorylation of AKT1 protein | PMID:19002579 PMID:22675305 PMID:24810525 PMID:25541178 PMID:26071184 PMID:36627075 | AKT1 | decreases phosphorylation | ISO | Akt1 (Mus musculus) | 6480464 | CTD | Streptozocin results in decreased phosphorylation of AKT1 protein | PMID:34649470 | AKT1 | increases expression | ISO | Akt1 (Rattus norvegicus) | 6480464 | CTD | Streptozocin results in increased expression of AKT1 mRNA | PMID:37081038 | AKT1 | multiple interactions | ISO | Akt1 (Rattus norvegicus) | 6480464 | CTD | [cobaltiprotoporphyrin co-treated with Streptozocin] results in increased phosphorylation of AKT1 protein; [Dietary Fats co-treated with Streptozocin] results in decreased phosphorylation of AKT1 protein; [Dietary Fats co-treated with Streptozocin] results in increased phosphorylation of AKT1 protein; [Resveratrol co-treated with Streptozocin] results in decreased phosphorylation of AKT1 protein; [Streptozocin co-treated with Coconut Oil co-treated with Cholesterol] results in decreased phosphorylation of AKT1 protein; [Streptozocin co-treated with Niacinamide] results in decreased phosphorylation of AKT1 protein; asiatic acid inhibits the reaction [Streptozocin results in decreased expression of AKT1 protein]; cobaltiprotoporphyrin inhibits the reaction [Streptozocin results in decreased phosphorylation of AKT1 protein]; Curcumin inhibits the reaction [Streptozocin results in decreased phosphorylation of AKT1 protein]; dapagliflozin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased phosphorylation of AKT1 protein]; eupafolin inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased phosphorylation of AKT1 protein]; Glyburide inhibits the reaction [Streptozocin results in decreased expression of AKT1 protein]; Metformin inhibits the reaction [[Streptozocin co-treated with Coconut Oil co-treated with Cholesterol] results in decreased phosphorylation of AKT1 protein]; Metformin inhibits the reaction [Streptozocin results in increased expression of AKT1 mRNA]; morin inhibits the reaction [Streptozocin results in increased expression of AKT1 mRNA]; myrtenal inhibits the reaction [Streptozocin results in decreased expression of AKT1 protein]; nerolidol inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased phosphorylation of AKT1 protein]; Phycocyanin inhibits the reaction [Streptozocin results in decreased expression of AKT1 mRNA]; piperlongumine inhibits the reaction [Streptozocin results in decreased expression of AKT1 protein]; Plant Extracts inhibits the reaction [[Streptozocin co-treated with Coconut Oil co-treated with Cholesterol] results in decreased phosphorylation of AKT1 protein]; Propofol promotes the reaction [Streptozocin results in decreased phosphorylation of AKT1 protein]; Quercetin inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased phosphorylation of AKT1 protein]; Resveratrol inhibits the reaction [Streptozocin results in decreased expression of AKT1 mRNA]; Rivastigmine inhibits the reaction [Streptozocin results in decreased expression of AKT1 mRNA]; Streptozocin results in decreased expression of and results in decreased phosphorylation of AKT1 protein; STUB1 inhibits the reaction [Streptozocin results in decreased expression of AKT1 protein]; tin mesoporphyrin inhibits the reaction [[cobaltiprotoporphyrin co-treated with Streptozocin] results in increased phosphorylation of AKT1 protein]; Tribulus extract inhibits the reaction [Streptozocin results in decreased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Phycocyanin inhibits the reaction [Streptozocin results in decreased expression of AKT1 mRNA]] | PMID:16595661 PMID:22675305 PMID:24810525 PMID:25541178 PMID:26071184 PMID:26286522 PMID:27417257 PMID:31877369 PMID:32805344 PMID:33724628 PMID:34391751 PMID:35414346 PMID:35442559 PMID:36169646 PMID:36627075 PMID:37566541 PMID:38706688 | AKT1 | multiple interactions | ISO | Akt1 (Mus musculus) | 6480464 | CTD | [Dietary Fats co-treated with Streptozocin] results in decreased expression of AKT1 mRNA; [Dietary Sugars co-treated with Dietary Fats co-treated with Streptozocin] results in decreased phosphorylation of AKT1 protein; [Streptozocin co-treated with CNR1 protein] affects the phosphorylation of AKT1 protein; [Streptozocin co-treated with Dietary Fats co-treated with Diethylhexyl Phthalate] results in decreased phosphorylation of AKT1 protein; [Streptozocin co-treated with Dietary Fats] results in decreased phosphorylation of AKT1 protein; Metformin inhibits the reaction [[Dietary Sugars co-treated with Dietary Fats co-treated with Streptozocin] results in decreased phosphorylation of AKT1 protein]; Metformin inhibits the reaction [Streptozocin results in decreased phosphorylation of AKT1 protein]; perilla seed oil inhibits the reaction [[Dietary Sugars co-treated with Dietary Fats co-treated with Streptozocin] results in decreased phosphorylation of AKT1 protein]; phillyrin inhibits the reaction [Streptozocin results in decreased phosphorylation of AKT1 protein] | PMID:30721768 PMID:31743741 PMID:33359794 PMID:33484791 PMID:34649470 | |
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