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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732909
Species: Homo sapiens
RGD Object: Gene
Symbol: AKT1
Name: AKT serine/threonine kinase 1
Acc ID: CHEBI:9288
Term: streptozocin
Definition: An N-nitrosourea that is an antibiotic produced by Streptomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.
Chemical ID: MESH:D013311
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
AKT1decreases expression ISOAkt1 (Rattus norvegicus)14401598RGDStreptozotocin decreases expression of Akt1 protein in the liver 
AKT1increases phosphorylationISOAkt1 (Mus musculus)156430337RGDstreptozocin increases phosphorylation of Akt1 protein in heart 
AKT1multiple interactionsISOAkt1 (Rattus norvegicus)408346751RGDStreptozocin decreases phosphorylation of Akt1 protein in the liver 
AKT1decreases expressionISOAkt1 (Rattus norvegicus)6480464CTDStreptozocin results in decreased expression of AKT1 mRNA; Streptozocin results in decreased expression of AKT1 proteinPMID:26071184 PMID:26286522 PMID:27417257 PMID:32805344 PMID:33724628 PMID:35414346
AKT1decreases phosphorylationISOAkt1 (Rattus norvegicus)6480464CTDStreptozocin results in decreased phosphorylation of AKT1 proteinPMID:19002579 PMID:22675305 PMID:24810525 PMID:25541178 PMID:26071184 PMID:36627075
AKT1decreases phosphorylationISOAkt1 (Mus musculus)6480464CTDStreptozocin results in decreased phosphorylation of AKT1 proteinPMID:34649470
AKT1increases expressionISOAkt1 (Rattus norvegicus)6480464CTDStreptozocin results in increased expression of AKT1 mRNAPMID:37081038
AKT1multiple interactionsISOAkt1 (Rattus norvegicus)6480464CTD[cobaltiprotoporphyrin co-treated with Streptozocin] results in increased phosphorylation of AKT1 protein; [Dietary Fats co-treated with Streptozocin] results in decreased phosphorylation of AKT1 protein; [Dietary Fats co-treated with Streptozocin] results in increased phosphorylation of AKT1 protein; [Resveratrol co-treated with Streptozocin] results in decreased phosphorylation of AKT1 protein; [Streptozocin co-treated with Coconut Oil co-treated with Cholesterol] results in decreased phosphorylation of AKT1 protein; [Streptozocin co-treated with Niacinamide] results in decreased phosphorylation of AKT1 protein; asiatic acid inhibits the reaction [Streptozocin results in decreased expression of AKT1 protein]; cobaltiprotoporphyrin inhibits the reaction [Streptozocin results in decreased phosphorylation of AKT1 protein]; Curcumin inhibits the reaction [Streptozocin results in decreased phosphorylation of AKT1 protein]; dapagliflozin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased phosphorylation of AKT1 protein]; eupafolin inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased phosphorylation of AKT1 protein]; Glyburide inhibits the reaction [Streptozocin results in decreased expression of AKT1 protein]; Metformin inhibits the reaction [[Streptozocin co-treated with Coconut Oil co-treated with Cholesterol] results in decreased phosphorylation of AKT1 protein]; Metformin inhibits the reaction [Streptozocin results in increased expression of AKT1 mRNA]; morin inhibits the reaction [Streptozocin results in increased expression of AKT1 mRNA]; myrtenal inhibits the reaction [Streptozocin results in decreased expression of AKT1 protein]; nerolidol inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased phosphorylation of AKT1 protein]; Phycocyanin inhibits the reaction [Streptozocin results in decreased expression of AKT1 mRNA]; piperlongumine inhibits the reaction [Streptozocin results in decreased expression of AKT1 protein]; Plant Extracts inhibits the reaction [[Streptozocin co-treated with Coconut Oil co-treated with Cholesterol] results in decreased phosphorylation of AKT1 protein]; Propofol promotes the reaction [Streptozocin results in decreased phosphorylation of AKT1 protein]; Quercetin inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased phosphorylation of AKT1 protein]; Resveratrol inhibits the reaction [Streptozocin results in decreased expression of AKT1 mRNA]; Rivastigmine inhibits the reaction [Streptozocin results in decreased expression of AKT1 mRNA]; Streptozocin results in decreased expression of and results in decreased phosphorylation of AKT1 protein; STUB1 inhibits the reaction [Streptozocin results in decreased expression of AKT1 protein]; tin mesoporphyrin inhibits the reaction [[cobaltiprotoporphyrin co-treated with Streptozocin] results in increased phosphorylation of AKT1 protein]; Tribulus extract inhibits the reaction [Streptozocin results in decreased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Phycocyanin inhibits the reaction [Streptozocin results in decreased expression of AKT1 mRNA]]PMID:16595661 PMID:22675305 PMID:24810525 PMID:25541178 PMID:26071184 PMID:26286522 PMID:27417257 PMID:31877369 PMID:32805344 PMID:33724628 PMID:34391751 PMID:35414346 PMID:35442559 PMID:36169646 PMID:36627075 PMID:37566541 PMID:38706688
AKT1multiple interactionsISOAkt1 (Mus musculus)6480464CTD[Dietary Fats co-treated with Streptozocin] results in decreased expression of AKT1 mRNA; [Dietary Sugars co-treated with Dietary Fats co-treated with Streptozocin] results in decreased phosphorylation of AKT1 protein; [Streptozocin co-treated with CNR1 protein] affects the phosphorylation of AKT1 protein; [Streptozocin co-treated with Dietary Fats co-treated with Diethylhexyl Phthalate] results in decreased phosphorylation of AKT1 protein; [Streptozocin co-treated with Dietary Fats] results in decreased phosphorylation of AKT1 protein; Metformin inhibits the reaction [[Dietary Sugars co-treated with Dietary Fats co-treated with Streptozocin] results in decreased phosphorylation of AKT1 protein]; Metformin inhibits the reaction [Streptozocin results in decreased phosphorylation of AKT1 protein]; perilla seed oil inhibits the reaction [[Dietary Sugars co-treated with Dietary Fats co-treated with Streptozocin] results in decreased phosphorylation of AKT1 protein]; phillyrin inhibits the reaction [Streptozocin results in decreased phosphorylation of AKT1 protein]PMID:30721768 PMID:31743741 PMID:33359794 PMID:33484791 PMID:34649470
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