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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68533
Species: Homo sapiens
RGD Object: Gene
Symbol: MTOR
Name: mechanistic target of rapamycin kinase
Acc ID: CHEBI:9288
Term: streptozocin
Definition: An N-nitrosourea that is an antibiotic produced by Streptomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.
Chemical ID: MESH:D013311
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MTORincreases phosphorylationISOMtor (Mus musculus)156430337RGDstreptozocin increases increases phosphorylation of Mtor protein in heart 
MTORdecreases expressionISOMtor (Rattus norvegicus)6480464CTDStreptozocin results in decreased expression of MTOR mRNAPMID:26071184
MTORincreases expressionISOMtor (Mus musculus)6480464CTDStreptozocin results in increased expression of MTOR protein modified formPMID:34428446
MTORmultiple interactionsISOMtor (Rattus norvegicus)6480464CTDResveratrol inhibits the reaction [Streptozocin results in decreased expression of MTOR mRNA]; Streptozocin results in decreased expression of and results in decreased phosphorylation of MTOR proteinPMID:26071184 PMID:38706688
MTORmultiple interactionsISOMtor (Mus musculus)6480464CTD5-Methoxypsoralen inhibits the reaction [Streptozocin results in increased expression of MTOR protein modified form]; [Streptozocin co-treated with Dietary Fats] results in decreased phosphorylation of MTOR protein; Diethylhexyl Phthalate promotes the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased phosphorylation of MTOR protein]; Tadalafil inhibits the reaction [Streptozocin results in increased expression of MTOR protein modified form]PMID:33484791 PMID:34428446
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