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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1313517
Species: Homo sapiens
RGD Object: Gene
Symbol: ATF6
Name: activating transcription factor 6
Acc ID: CHEBI:9288
Term: streptozocin
Definition: An N-nitrosourea that is an antibiotic produced by Streptomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.
Chemical ID: MESH:D013311
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ATF6increases expression ISOAtf6 (Mus musculus)156430337RGDstreptozocin increases expression of Atf6 protein in heart 
ATF6increases cleavageISOAtf6 (Rattus norvegicus)6480464CTDStreptozocin results in increased cleavage of ATF6 proteinPMID:30980806
ATF6multiple interactionsISOAtf6 (Rattus norvegicus)6480464CTD4-phenylbutyric acid inhibits the reaction [Streptozocin results in increased cleavage of ATF6 protein]; [Streptozocin co-treated with Dietary Fats co-treated with Fructose] results in increased expression of ATF6 protein; Chlorogenic Acid inhibits the reaction [[Streptozocin co-treated with Dietary Fats co-treated with Fructose] results in increased expression of ATF6 protein]; Metformin inhibits the reaction [[Streptozocin co-treated with Dietary Fats co-treated with Fructose] results in increased expression of ATF6 protein]PMID:30980806 PMID:34801538
ATF6multiple interactionsISOAtf6 (Mus musculus)6480464CTD[Dietary Fats co-treated with Streptozocin] results in increased expression of ATF6 mRNA; NUS1 protein inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of ATF6 mRNA]PMID:33812996
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