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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3311
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pfkl
Name: phosphofructokinase, liver type
Acc ID: CHEBI:92278
Term: 1-[4,4-bis(4-fluorophenyl)butyl]-4-[4-chloro-3-(trifluoromethyl)phenyl]-4-piperidinol
Definition: A diarylmethane that has formula C28H27ClF5NO.
Chemical ID: MESH:D010395
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pfkldecreases activityISOPFKL (Homo sapiens)6480464CTDPenfluridol results in decreased activity of PFKL proteinPMID:35530161
Pfklincreases response to substanceISOPFKL (Homo sapiens)6480464CTDPFKL protein results in increased susceptibility to PenfluridolPMID:35530161
Pfklmultiple interactionsISOPFKL (Homo sapiens)6480464CTDPenfluridol binds to and results in decreased activity of PFKL protein; PFKL protein affects the reaction [Penfluridol affects the localization of FOXO3A protein]; PFKL protein affects the reaction [Penfluridol results in increased cleavage of CASP3 protein]; PFKL protein affects the reaction [Penfluridol results in increased expression of BCL2L11 mRNA]; PFKL protein affects the reaction [Penfluridol results in increased expression of BCL2L11 protein]PMID:35530161
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