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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 628622
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Alk
Name: ALK receptor tyrosine kinase
Acc ID: CHEBI:90936
Term: alectinib
Definition: An organic heterotetracyclic compound that is 6,6-dimethyl-5,6-dihydro-11H-benzo[b]carbazol-11-one carrying additional cyano, 4-(morpholin-4-yl)piperidin-1-yl and ethyl substituents at positions 3, 8 and 9 respectively. Used (as the hydrochloride salt) for the treatment of patients with anaplastic lymphoma kinase-positive, metastatic non-small cell lung cancer.
Chemical ID: MESH:C582670
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Alkaffects response to substanceISOALK (Homo sapiens)6480464CTDALK protein affects the susceptibility to alectinibPMID:29458018
Alkdecreases activityISOALK (Homo sapiens)6480464CTDalectinib results in decreased activity of ALK proteinPMID:26144315
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