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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1566127
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Prss53
Name: serine protease 53
Acc ID: CHEBI:75998
Term: trametinib
Definition: A pyridopyrimidine that is used (as its dimethyl sulfoxide addition compound) for the treatment of patients with unresectable or metastatic melanoma with BRAF V600E or V600K mutations, and who have not received prior BRAF inhibitor treatment.
Chemical ID: MESH:C560077
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Prss53multiple interactionsISOPRSS53 (Homo sapiens)6480464CTD[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of PRSS53 mRNAPMID:36139627
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